Ricardo Miledi - Related publications

Affiliations: 
University of California, Irvine, Irvine, CA 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Pollok S, Reiner A. Subunit-selective iGluR antagonists can potentiate heteromeric receptor responses by blocking desensitization. Proceedings of the National Academy of Sciences of the United States of America. 117: 25851-25858. PMID 32999066 DOI: 10.1073/pnas.2007471117   
2020 Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh RM, Lindahl E, Hibbs RE. Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature. PMID 32879488 DOI: 10.1038/s41586-020-2654-5   
2020 Yeh KC, Hung CF, Lin YF, Chang C, Pai MS, Wang SJ. Neferine, a bisbenzylisoquinoline alkaloid of Nelumbo nucifera, inhibits glutamate release in rat cerebrocortical nerve terminals through 5-HT receptors. European Journal of Pharmacology. 173589. PMID 32961171 DOI: 10.1016/j.ejphar.2020.173589   
2020 Jin Y, Qiu CY, Wei S, Han L, Liu TT, Hu WP. Potentiation of P2X3 receptor mediated currents by endothelin-1 in rat dorsal root ganglion neurons. Neuropharmacology. 108356. PMID 33069757 DOI: 10.1016/j.neuropharm.2020.108356   
2020 Andrejew R, Oliveira-Giacomelli Á, Ribeiro DE, Glaser T, Arnaud-Sampaio VF, Lameu C, Ulrich H. The P2X7 Receptor: Central Hub of Brain Diseases. Frontiers in Molecular Neuroscience. 13: 124. PMID 32848594 DOI: 10.3389/fnmol.2020.00124   
2020 Rodriguez Araujo N, Fabiani C, Mazzarini Dimarco A, Bouzat C, Corradi J. Orthosteric and Allosteric Activation of Human 5-HTA Receptors. Biophysical Journal. PMID 32946769 DOI: 10.1016/j.bpj.2020.08.029   
2020 Wang S, Liu H, Lei K, Li G, Li J, Wei Y, Wang X, Liu R. Synthesis of 3,4-dihydroquinolin-2(1H)-one derivatives with anticonvulsant activity and their binding to the GABA receptor. Bioorganic Chemistry. 103: 104182. PMID 32890992 DOI: 10.1016/j.bioorg.2020.104182   
2020 Andrade F, Rangel-Sandoval C, Rodríguez-Hernández A, López-Dyck E, Elizalde A, Virgen-Ortiz A, Bonales-Alatorre E, Valencia-Cruz G, Sánchez-Pastor E. Capsaicin Causes Vasorelaxation of Rat Aorta through Blocking of L-type Ca Channels and Activation of CB Receptors. Molecules (Basel, Switzerland). 25. PMID 32872656 DOI: 10.3390/molecules25173957   
2020 Pismataro MC, Horenstein NA, Stokes C, Quadri M, De Amici M, Papke RL, Dallanoce C. Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation. European Journal of Medicinal Chemistry. 205: 112669. PMID 32810771 DOI: 10.1016/j.ejmech.2020.112669   
2020 Chen H, Gu X, Zeng Q, Mao Z, Martyniuk CJ. Characterization of the GABAergic system in Asian clam Corbicula fluminea: Phylogenetic analysis, tissue distribution, and response to the aquatic contaminant carbamazepine. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp. 108896. PMID 32949817 DOI: 10.1016/j.cbpc.2020.108896   
2020 Norel X, Sugimoto Y, Ozen G, Abdelazeem H, Amgoud Y, Bouhadoun A, Bassiouni W, Goepp M, Mani S, Manikpurage HD, Senbel A, Longrois D, Heinemann A, Yao C, Clapp LH. International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions. Pharmacological Reviews. 72: 910-968. PMID 32962984 DOI: 10.1124/pr.120.019331   
2020 Williams CA, Miller KE, Williams NP, Portfors CV, Perkel DJ. Distribution and co-expression of adrenergic receptor-encoding mRNA in the mouse inferior colliculus. The Journal of Comparative Neurology. PMID 33067825 DOI: 10.1002/cne.25053   
2020 Hino N, Marumo T, Kotani M, Shimazaki T, Kaku-Fukumoto A, Hikichi H, Karasawa JI, Tomishima Y, Komiyama H, Tatsuda E, Nozawa D, Nakamura T, Chaki S. A Novel Potent and Selective Histamine H3 Receptor Antagonist Enerisant: In Vitro Profiles, In Vivo Receptor Occupancy, Wake-Promoting and Pro-cognitive Effects in Rodents. The Journal of Pharmacology and Experimental Therapeutics. PMID 32862143 DOI: 10.1124/jpet.120.000185   
2020 Walsh KB, Andersen HK. Molecular Pharmacology of Synthetic Cannabinoids: Delineating CB1 Receptor-Mediated Cell Signaling. International Journal of Molecular Sciences. 21. PMID 32854313 DOI: 10.3390/ijms21176115   
2020 Li Z, Luo W, Fang S, Chen X, Lin T, Zhou S, Zhang L, Yang W, Li Z, Jiantao Y, Junjian W, Liu P, Li Z. Prostacyclin facilitates vascular smooth muscle cell phenotypic transformation via activating TP receptors when IP receptors are deficient. Acta Physiologica (Oxford, England). e13555. PMID 32886850 DOI: 10.1111/apha.13555   
2020 Glaser T, Andrejew R, Oliveira-Giacomelli Á, Ribeiro DE, Bonfim Marques L, Ye Q, Ren WJ, Semyanov A, Illes P, Tang Y, Ulrich H. Purinergic Receptors in Basal Ganglia Diseases: Shared Molecular Mechanisms between Huntington's and Parkinson's Disease. Neuroscience Bulletin. PMID 33026587 DOI: 10.1007/s12264-020-00582-8   
2020 Kozma MT, Ngo-Vu H, Rump MT, Bobkov YV, Ache BW, Derby CD. Single cell transcriptomes reveal expression patterns of chemoreceptor genes in olfactory sensory neurons of the Caribbean spiny lobster, Panulirus argus. Bmc Genomics. 21: 649. PMID 32962631 DOI: 10.1186/s12864-020-07034-7   
2020 Singh N, Villoutreix BO. Demystifying the Molecular Basis of Pyrazoloquinolinones Recognition at the Extracellular α1+/β3- Interface of the GABA Receptor by Molecular Modeling. Frontiers in Pharmacology. 11: 561834. PMID 33041802 DOI: 10.3389/fphar.2020.561834   
2020 Sun X, Zhou R, Lei Y, Hu J, Li X. The ligand-gated ion channel P2X7 receptor mediates NLRP3/caspase-1-mediated pyroptosis in cerebral cortical neurons of juvenile rats with sepsis. Brain Research. 147109. PMID 32905819 DOI: 10.1016/j.brainres.2020.147109   
2020 Rukavina Mikusic NL, Silva MG, Pineda AM, Gironacci MM. Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function? Frontiers in Pharmacology. 11: 1179. PMID 32848782 DOI: 10.3389/fphar.2020.01179   
2020 Wang M, Li N, Jing S, Wang C, Sun J, Li H, Liu J, Chen J. Schisandrin B exerts hypnotic effects in PCPA-treated rats by increasing hypothalamic 5-HT and γ-aminobutyric acid levels. Experimental and Therapeutic Medicine. 20: 142. PMID 33093880 DOI: 10.3892/etm.2020.9271   
2020 Rojas JJ, Vargas-Lagos C, Martínez D, Oyarzún-Salazar R, Pontigo JP, Morera F, Vargas-Chacoff L. Francisella noatunensis subsp. noatunensis triggers calcium metabolism gene modulation in Eleginops maclovinus. Comparative Biochemistry and Physiology. Part a, Molecular & Integrative Physiology. 250: 110805. PMID 32927078 DOI: 10.1016/j.cbpa.2020.110805   
2020 Castro MJ, Turani O, Faraoni MB, Gerbino D, Bouzat C. A New Antagonist of Glutamate-Activated Chloride Channels With Anthelmintic Activity. Frontiers in Neuroscience. 14: 879. PMID 32973433 DOI: 10.3389/fnins.2020.00879   
2020 Gan Z, Cheng J, Chen S, Hou J, Li N, Xia H, Xia L, Lu Y, Nie P. Identification and characterization of tilapia CRFB1, CRFB2 and CRFB5 reveals preferential receptor usage of three IFN subtypes in perciform fishes. Fish & Shellfish Immunology. PMID 33011433 DOI: 10.1016/j.fsi.2020.10.002   
2020 Chang Y, Wang Y, Venton BJ. A1 and A2A receptors modulate spontaneous adenosine but not mechanically-stimulated adenosine in the caudate. Acs Chemical Neuroscience. PMID 32976713 DOI: 10.1021/acschemneuro.0c00510   
2020 Corboz MR, Salvail W, Gagnon S, LaSala D, Laurent CE, Salvail D, Chen KJ, Cipolla D, Perkins WR, Chapman RW. Prostanoid receptor subtypes involved in treprostinil-mediated vasodilation of rat pulmonary arteries and in treprostinil-mediated inhibition of collagen gene expression of human lung fibroblasts. Prostaglandins & Other Lipid Mediators. 106486. PMID 33011365 DOI: 10.1016/j.prostaglandins.2020.106486   
2020 Jacobson KA, Salmaso V. Purinergic signaling: Impact of GPCR structures on rational drug design. Chemmedchem. PMID 32803849 DOI: 10.1002/cmdc.202000465   
2020 Sarkar P, Jafurulla M, Bhowmick S, Chattopadhyay A. Structural Stringency and Optimal Nature of Cholesterol Requirement in the Function of the Serotonin Receptor. The Journal of Membrane Biology. PMID 32949248 DOI: 10.1007/s00232-020-00138-x   
2020 Cifani C, Micioni Di Bonaventura E, Botticelli L, Del Bello F, Giorgioni G, Pavletić P, Piergentili A, Quaglia W, Bonifazi A, Schepmann D, Wünsch B, Vistoli G, Micioni Di Bonaventura MV. Novel Highly Potent and Selective Sigma1 Receptor Antagonists Effectively Blocking the Binge Eating Episode in Female Rats. Acs Chemical Neuroscience. PMID 32886484 DOI: 10.1021/acschemneuro.0c00456   
2020 Sahoo S, Kharkar PS, Sahu NU, S B. Anxiolytic activity of Psidium guajava in mice subjected to chronic restraint stress and effect on neurotransmitters in brain. Phytotherapy Research : Ptr. PMID 33034100 DOI: 10.1002/ptr.6900   
2020 Emerich BL, Ferreira RCM, Machado-de-Avila RA, Resende JM, Duarte IDG, de Lima ME. PnAn13, an antinociceptive synthetic peptide inspired in the toxin PnTx4(6-1) (δ-Ctenitoxin-Pn1a). Toxicon: X. 7: 100045. PMID 32875290 DOI: 10.1016/j.toxcx.2020.100045   
2020 Ramesh S, Park S, Call MJ, Im W, Call ME. Experimentally Guided Computational Methods Yield Highly Accurate Insights into Transmembrane Interactions within the T Cell Receptor Complex. The Journal of Physical Chemistry. B. PMID 33030343 DOI: 10.1021/acs.jpcb.0c06403   
2020 Pieterse L, van der Walt MM, Terre'Blanche G. C2-substituted quinazolinone derivatives exhibit A and/or A adenosine receptor affinities in the low micromolar range. Bioorganic & Medicinal Chemistry Letters. 30: 127274. PMID 32631506 DOI: 10.1016/j.bmcl.2020.127274   
2020 Hosten LO, Snyder C. Over-the-Counter Ocular Decongestants in the United States - Mechanisms of Action and Clinical Utility for Management of Ocular Redness. Clinical Optometry. 12: 95-105. PMID 32801982 DOI: 10.2147/OPTO.S259398   
2020 Xie XY, Li YY, Ma WH, Chen AF, Sun YT, Lee JY, Riad A, Xu DH, Mach RH, Huang YS. Synthesis, binding, and functional properties of tetrahydroisoquinolino-2-alkyl phenones as selective σR/TMEM97 ligands. European Journal of Medicinal Chemistry. 209: 112906. PMID 33049607 DOI: 10.1016/j.ejmech.2020.112906   
2020 Akk G, Germann AL, Sugasawa Y, Pierce SR, Evers AS, Steinbach JH. Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABA Receptor: Relating Occupancy to State Functions. Molecular Pharmacology. 98: 303-313. PMID 32873746 DOI: 10.1124/molpharm.120.000066   
2020 Gimeno-Martos S, Santorromán-Nuez M, Cebrián-Pérez JA, Muiño-Blanco T, Pérez-Pé R, Casao A. Involvement of progesterone and estrogen receptors in the ram sperm acrosome reaction. Domestic Animal Endocrinology. 74: 106527. PMID 32799038 DOI: 10.1016/j.domaniend.2020.106527   
2020 Butenas ALE, Rollins KS, Matney JE, Williams AC, Kleweno TE, Parr SK, Hammond ST, Ade CJ, Hageman KS, Musch TI, Copp SW. No effect of endoperoxide 4 or thromboxane A receptor blockade on static mechanoreflex activation in rats with heart failure. Experimental Physiology. PMID 32954541 DOI: 10.1113/EP088835   
2020 Liu X, Wu Y, Zhou D, Xie Y, Zhou Y, Lu Y, Yang R, Liu S. N‑linoleyltyrosine protects PC12 cells against oxidative damage via autophagy: Possible involvement of CB1 receptor regulation. International Journal of Molecular Medicine. 46: 1827-1837. PMID 33000188 DOI: 10.3892/ijmm.2020.4706   
2020 Silwal P, Paik S, Jeon SM, Jo EK. Nuclear Receptors as Autophagy-Based Antimicrobial Therapeutics. Cells. 9. PMID 32867365 DOI: 10.3390/cells9091979   
2020 Gao L, Yang Z, Xiong J, Hao C, Ma R, Liu X, Liu BF, Jin J, Zhang G, Chen Y. Design, Synthesis and Biological Investigation of Flavone Derivatives as Potential Multi-Receptor Atypical Antipsychotics. Molecules (Basel, Switzerland). 25. PMID 32911828 DOI: 10.3390/molecules25184107   
2020 Conte G, Nguyen NT, Alves M, de Diego-Garcia L, Kenny A, Nicke A, Henshall DC, Jimenez-Mateos EM, Engel T. P2X7 Receptor-Dependent microRNA Expression Profile in the Brain Following Status Epilepticus in Mice. Frontiers in Molecular Neuroscience. 13: 127. PMID 32982684 DOI: 10.3389/fnmol.2020.00127   
2020 Saheb Sharif-Askari N, Saheb Sharif-Askari F, Mdkhana B, Al Heialy S, Ratemi E, Alghamdi M, Abusnana S, Kashour T, Hamid Q, Halwani R. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Archives of Toxicology. PMID 32808185 DOI: 10.1007/s00204-020-02869-1   
2020 Chen H, Wang F, Ni X, Rigui Y, Bai Y, Xu L, Yang J, Zhang X, Deng J, Li J, Yin X, Ao W, Kwok KWH, Dong W. Aconitine disrupts serotonin neurotransmission via 5-hydroxytryptamine receptor in zebrafish embryo. Journal of Applied Toxicology : Jat. PMID 33085127 DOI: 10.1002/jat.4059   
2020 Pereira PMR, Mandleywala K, Ragupathi A, Lewis JS. Acute statin treatment improves antibody accumulation in EGFR- and PSMA-expressing tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32998959 DOI: 10.1158/1078-0432.CCR-20-1960   
2020 Senn L, Cannazza G, Biagini G. Receptors and Channels Possibly Mediating the Effects of Phytocannabinoids on Seizures and Epilepsy. Pharmaceuticals (Basel, Switzerland). 13. PMID 32751761 DOI: 10.3390/ph13080174   
2020 Ellaithy A, Gonzalez-Maeso J, Logothetis DA, Levitz J. Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function. Trends in Biochemical Sciences. PMID 32861513 DOI: 10.1016/j.tibs.2020.07.008   
2020 de la Rosa R, Schlezinger JJ, Smith MT, Webster TF. Application of generalized concentration addition to predict mixture effects of glucocorticoid receptor ligands. Toxicology in Vitro : An International Journal Published in Association With Bibra. 104975. PMID 32858110 DOI: 10.1016/j.tiv.2020.104975   
2020 Hinnah K, Willems S, Morstein J, Heering J, Hartrampf F, Broichhagen J, Leippe P, Merk D, Trauner D. Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR). Journal of Medicinal Chemistry. PMID 32886507 DOI: 10.1021/acs.jmedchem.0c00654   
2020 Li B, Li L, Wang W, Meng J, Xu F, Wu F, Zhang G. Characterization of Free Fatty Acid Receptor 4 and Its Involvement in Nutritional Control and Immune Response in Pacific Oysters (). Acs Omega. 5: 21355-21363. PMID 32905352 DOI: 10.1021/acsomega.0c01325