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Alexis L. Kaushansky, Ph.D. - Publications

Affiliations: 
2010 Harvard University, Cambridge, MA, United States 
Area:
Protein Systems
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53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Glennon EK, Wei L, Roobsoong W, Primavera VI, Tongogara T, Yee CB, Sattabongkot J, Kaushansky A. Host kinase regulation of dormant and replicating liver stages. Biorxiv : the Preprint Server For Biology. PMID 38014051 DOI: 10.1101/2023.11.13.566868  0.801
2023 Pitre Z, Seltzer T, Kalthoff C, Benitez-Cortez M, Yee C, Glennon EKK, Primavera VI, Kaushansky A. Protocol for assembling and implementing a partially automated system for rearing and handling Anopheles stephensi mosquitoes. Star Protocols. 4: 102621. PMID 37776521 DOI: 10.1016/j.xpro.2023.102621  0.674
2023 Rodríguez-Hernández D, Vijayan K, Zigweid R, Fenwick MK, Sankaran B, Roobsoong W, Sattabongkot J, Glennon EKK, Myler PJ, Sunnerhagen P, Staker BL, Kaushansky A, Grøtli M. Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts. Nature Communications. 14: 5408. PMID 37669940 DOI: 10.1038/s41467-023-41119-7  0.742
2023 Kaushansky A, Minkah N. Liver-stage Plasmodium infection tunes clinical outcomes. Trends in Parasitology. 39: 321-322. PMID 36935339 DOI: 10.1016/j.pt.2023.03.004  0.363
2022 Carter CC, Mast FD, Olivier JP, Bourgeois NM, Kaushansky A, Aitchison JD. Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication. Frontiers in Cellular and Infection Microbiology. 12: 979996. PMID 36171757 DOI: 10.3389/fcimb.2022.979996  0.303
2022 Visweswaran GRR, Vijayan K, Chandrasekaran R, Trakhimets O, Brown SL, Vigdorovich V, Yang A, Raappana A, Watson A, Selman W, Zuck M, Dambrauskas N, Kaushansky A, Sather DN. Germinal center activity and B cell maturation are associated with protective antibody responses against Plasmodium pre-erythrocytic infection. Plos Pathogens. 18: e1010671. PMID 35793394 DOI: 10.1371/journal.ppat.1010671  0.715
2022 Vijayan K, Arang N, Wei L, Morrison R, Geiger R, Parks KR, Lewis AJ, Mast FD, Douglass AN, Kain HS, Aitchison JD, Johnson JS, Aderem A, Kaushansky A. A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection. Cell Chemical Biology. PMID 35738280 DOI: 10.1016/j.chembiol.2022.06.001  0.825
2022 Glennon EKK, Tongogara T, Primavera VI, Reeder SM, Wei L, Kaushansky A. Elucidating Spatially-Resolved Changes in Host Signaling During Liver-Stage Infection. Frontiers in Cellular and Infection Microbiology. 11: 804186. PMID 35111697 DOI: 10.3389/fcimb.2021.804186  0.786
2021 Vijayan K, Visweswaran GRR, Chandrasekaran R, Trakhimets O, Brown SL, Watson A, Zuck M, Dambrauskas N, Raappana A, Carbonetti S, Kelnhofer-Millevolte L, Glennon EKK, Postiglione R, Sather DN, Kaushansky A. Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium yoelii liver stage. Cell Reports. 36: 109489. PMID 34348141 DOI: 10.1016/j.celrep.2021.109489  0.791
2021 Dankwa S, Dols MM, Wei L, Glennon EKK, Kain HS, Kaushansky A, Smith JD. Exploiting polypharmacology to dissect host kinases and kinase inhibitors that modulate endothelial barrier integrity. Cell Chemical Biology. PMID 34216546 DOI: 10.1016/j.chembiol.2021.06.004  0.769
2021 Vijayan K, Wei L, Glennon EKK, Mattocks C, Bourgeois N, Staker B, Kaushansky A. Host-targeted Interventions as an Exciting Opportunity to Combat Malaria. Chemical Reviews. PMID 34197083 DOI: 10.1021/acs.chemrev.1c00062  0.752
2020 Navare AT, Mast FD, Olivier JP, Bertomeu T, Neal M, Carpp LN, Kaushansky A, Coulombe-Huntington J, Tyers M, Aitchison JD. Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality. Biorxiv : the Preprint Server For Biology. PMID 33173868 DOI: 10.1101/2020.10.12.336487  0.3
2020 Mast FD, Navare AT, van der Sloot AM, Coulombe-Huntington J, Rout MP, Baliga NS, Kaushansky A, Chait BT, Aderem A, Rice CM, Sali A, Tyers M, Aitchison JD. Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality. The Journal of Cell Biology. 219. PMID 32785687 DOI: 10.1083/Jcb.202006159  0.368
2019 Harupa A, de Las Heras L, Colmenarejo G, Lyons-Abbott S, Reers A, Caballero Hernandez I, Chung CW, Charter D, Myler PJ, Fernandez-Menendez RM, Calderon F, Palomo S, Rodriguez B, Berlanga M, Herreros-Avilés E, ... ... Kaushansky A, et al. Identification of selective inhibitors of Plasmodium N-myristoyltransferase by high-throughput screening. Journal of Medicinal Chemistry. PMID 31850752 DOI: 10.1021/Acs.Jmedchem.9B01343  0.367
2019 Vijayan K, Cestari I, Mast FD, Glennon EKK, McDermott SM, Kain HS, Brokaw AM, Aitchison JD, Stuart K, Kaushansky A. Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry. Iscience. 21: 603-611. PMID 31731198 DOI: 10.1016/J.Isci.2019.10.054  0.813
2019 Tran TM, Guha R, Portugal S, Skinner J, Ongoiba A, Bhardwaj J, Jones M, Moebius J, Venepally P, Doumbo S, DeRiso EA, Li S, Vijayan K, Anzick SL, Hart GT, ... ... Kaushansky A, et al. A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation. Immunity. PMID 31492649 DOI: 10.1016/J.Immuni.2019.08.009  0.334
2019 Kain HS, Glennon EKK, Vijayan K, Arang N, Douglass AN, Fortin CL, Zuck M, Lewis AJ, Whiteside SL, Dudgeon DR, Johnson JS, Aderem A, Stevens KR, Kaushansky A. Liver stage malaria infection is controlled by host regulators of lipid peroxidation. Cell Death and Differentiation. PMID 31065106 DOI: 10.1038/S41418-019-0338-1  0.805
2019 Glennon EKK, Austin LS, Arang N, Kain HS, Mast FD, Vijayan K, Aitchison JD, Kappe SHI, Kaushansky A. Alterations in Phosphorylation of Hepatocyte Ribosomal Protein S6 Control Plasmodium Liver Stage Infection. Cell Reports. 26: 3391-3399.e4. PMID 30893610 DOI: 10.1016/J.Celrep.2019.02.085  0.831
2018 Patterson NH, Tuck M, Lewis A, Kaushansky A, Norris JL, Van de Plas R, Caprioli RM. Next Generation Histology-directed Imaging Mass Spectrometry Driven by Autofluorescence Microscopy. Analytical Chemistry. PMID 30274514 DOI: 10.1021/Acs.Analchem.8B02885  0.609
2018 Glennon EKK, Dankwa S, Smith JD, Kaushansky A. Opportunities for Host-targeted Therapies for Malaria. Trends in Parasitology. PMID 30122551 DOI: 10.1016/J.Pt.2018.07.011  0.776
2017 Steel RWJ, Pei Y, Camargo N, Kaushansky A, Dankwa DA, Martinson T, Nguyen T, Betz W, Cardamone H, Vigdorovich V, Dambrauskas N, Carbonetti S, Vaughan AM, Sather ND, Kappe SHI. Plasmodium yoelii S4/CelTOS is important for sporozoite gliding motility and cell traversal. Cellular Microbiology. PMID 29253313 DOI: 10.1111/Cmi.12817  0.474
2017 Zuck M, Austin LS, Danziger SA, Aitchison JD, Kaushansky A. The Promise of Systems Biology Approaches for Revealing Host Pathogen Interactions in Malaria. Frontiers in Microbiology. 8: 2183. PMID 29201016 DOI: 10.3389/Fmicb.2017.02183  0.793
2017 Arang N, Kain HS, Glennon EK, Bello T, Dudgeon DR, Walter ENF, Gujral TS, Kaushansky A. Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles. Nature Communications. 8: 1232. PMID 29089541 DOI: 10.1038/S41467-017-01345-2  0.821
2015 Kaushansky A, Douglass AN, Arang N, Vigdorovich V, Dambrauskas N, Kain HS, Austin LS, Sather DN, Kappe SH. Malaria parasites target the hepatocyte receptor EphA2 for successful host infection. Science (New York, N.Y.). 350: 1089-92. PMID 26612952 DOI: 10.1126/Science.Aad3318  0.842
2015 Douglass AN, Metzger PG, Kappe SH, Kaushansky A. Flow Cytometry-Based Assessment of Antibody Function Against Malaria Pre-erythrocytic Infection. Methods in Molecular Biology (Clifton, N.J.). 1325: 49-58. PMID 26450378 DOI: 10.1007/978-1-4939-2815-6_4  0.67
2015 Kaushansky A, Kappe SH. Host ER stress during malaria parasite infection. Embo Reports. 16: 883-4. PMID 26138101 DOI: 10.15252/Embr.201540792  0.738
2015 Kaushansky A, Kappe SH. Selection and refinement: the malaria parasite's infection and exploitation of host hepatocytes. Current Opinion in Microbiology. 26: 71-8. PMID 26102161 DOI: 10.1016/J.Mib.2015.05.013  0.741
2015 Mikolajczak SA, Vaughan AM, Kangwanrangsan N, Roobsoong W, Fishbaugher M, Yimamnuaychok N, Rezakhani N, Lakshmanan V, Singh N, Kaushansky A, Camargo N, Baldwin M, Lindner SE, Adams JH, Sattabongkot J, et al. Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice. Cell Host & Microbe. 17: 526-35. PMID 25800544 DOI: 10.1016/J.Chom.2015.02.011  0.818
2015 Douglass AN, Kain HS, Abdullahi M, Arang N, Austin LS, Mikolajczak SA, Billman ZP, Hume JC, Murphy SC, Kappe SH, Kaushansky A. Host-based Prophylaxis Successfully Targets Liver Stage Malaria Parasites. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 857-65. PMID 25648263 DOI: 10.1038/Mt.2015.18  0.838
2015 Kaushansky A, Austin LS, Mikolajczak SA, Lo FY, Miller JL, Douglass AN, Arang N, Vaughan AM, Gardner MJ, Kappe SH. Susceptibility to Plasmodium yoelii preerythrocytic infection in BALB/c substrains is determined at the point of hepatocyte invasion. Infection and Immunity. 83: 39-47. PMID 25312960 DOI: 10.1128/Iai.02230-14  0.716
2015 Mikolajczak SA, Vaughan AM, Kangwanrangsan N, Roobsoong W, Fishbaugher M, Yimamnuaychok N, Rezakhani N, Lakshmanan V, Singh N, Kaushansky A, Camargo N, Baldwin M, Lindner SE, Adams JH, Sattabongkot J, et al. Erratum: Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice (Cell Host and Microbe (2015) 17 (526-535)) Cell Host & Microbe. 17. DOI: 10.1016/J.Chom.2015.03.015  0.744
2014 Kaushansky A, Kaushansky K. Systems biology of megakaryocytes. Advances in Experimental Medicine and Biology. 844: 59-84. PMID 25480637 DOI: 10.1007/978-1-4939-2095-2_4  0.335
2014 Mikolajczak SA, Lakshmanan V, Fishbaugher M, Camargo N, Harupa A, Kaushansky A, Douglass AN, Baldwin M, Healer J, O'Neill M, Phuong T, Cowman A, Kappe SH. A next-generation genetically attenuated Plasmodium falciparum parasite created by triple gene deletion. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 1707-15. PMID 24827907 DOI: 10.1038/Mt.2014.85  0.658
2014 Austin LS, Kaushansky A, Kappe SH. Susceptibility to Plasmodium liver stage infection is altered by hepatocyte polyploidy. Cellular Microbiology. 16: 784-95. PMID 24612025 DOI: 10.1111/Cmi.12282  0.739
2014 Sangkhae V, Saur SJ, Kaushansky A, Kaushansky K, Hitchcock IS. Phosphorylated c-Mpl tyrosine 591 regulates thrombopoietin-induced signaling. Experimental Hematology. 42: 477-86.e4. PMID 24607955 DOI: 10.1016/J.Exphem.2014.02.007  0.356
2014 Finney OC, Keitany GJ, Smithers H, Kaushansky A, Kappe S, Wang R. Immunization with genetically attenuated P. falciparum parasites induces long-lived antibodies that efficiently block hepatocyte invasion by sporozoites. Vaccine. 32: 2135-8. PMID 24582635 DOI: 10.1016/J.Vaccine.2014.02.055  0.647
2014 Kaushansky A, Mikolajczak SA, Vignali M, Kappe SH. Of men in mice: the success and promise of humanized mouse models for human malaria parasite infections. Cellular Microbiology. 16: 602-11. PMID 24506682 DOI: 10.1111/Cmi.12277  0.671
2014 Sack BK, Miller JL, Vaughan AM, Douglass A, Kaushansky A, Mikolajczak S, Coppi A, Gonzalez-Aseguinolaza G, Tsuji M, Zavala F, Sinnis P, Kappe SH. Model for in vivo assessment of humoral protection against malaria sporozoite challenge by passive transfer of monoclonal antibodies and immune serum. Infection and Immunity. 82: 808-17. PMID 24478094 DOI: 10.1128/Iai.01249-13  0.707
2013 Kaushansky A, Metzger PG, Douglass AN, Mikolajczak SA, Lakshmanan V, Kain HS, Kappe SH. Malaria parasite liver stages render host hepatocytes susceptible to mitochondria-initiated apoptosis. Cell Death & Disease. 4: e762. PMID 23928701 DOI: 10.1038/Cddis.2013.286  0.834
2013 Kaushansky A, Ye AS, Austin LS, Mikolajczak SA, Vaughan AM, Camargo N, Metzger PG, Douglass AN, MacBeath G, Kappe SH. Suppression of host p53 is critical for Plasmodium liver-stage infection. Cell Reports. 3: 630-7. PMID 23478020 DOI: 10.1016/J.Celrep.2013.02.010  0.814
2013 Koytiger G, Kaushansky A, Gordus A, Rush J, Sorger PK, MacBeath G. Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected. Molecular & Cellular Proteomics : McP. 12: 1204-13. PMID 23358503 DOI: 10.1074/Mcp.M112.025858  0.761
2012 Vaughan AM, Mikolajczak SA, Wilson EM, Grompe M, Kaushansky A, Camargo N, Bial J, Ploss A, Kappe SH. Complete Plasmodium falciparum liver-stage development in liver-chimeric mice. The Journal of Clinical Investigation. 122: 3618-28. PMID 22996664 DOI: 10.1172/Jci62684  0.725
2012 Kaushansky A, Rezakhani N, Mann H, Kappe SH. Development of a quantitative flow cytometry-based assay to assess infection by Plasmodium falciparum sporozoites. Molecular and Biochemical Parasitology. 183: 100-3. PMID 22342965 DOI: 10.1016/J.Molbiopara.2012.01.006  0.698
2011 Kaushansky A, Kappe SH. The crucial role of hepatocyte growth factor receptor during liver-stage infection is not conserved among Plasmodium species. Nature Medicine. 17: 1180-1; author reply. PMID 21988987 DOI: 10.1038/Nm.2456  0.664
2011 Jung AS, Kaushansky A, Macbeath G, Kaushansky K. Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling. Cell Cycle (Georgetown, Tex.). 10: 1838-44. PMID 21527831 DOI: 10.4161/Cc.10.11.15776  0.599
2010 Boettcher JP, Kirchner M, Churin Y, Kaushansky A, Pompaiah M, Thorn H, Brinkmann V, Macbeath G, Meyer TF. Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements. Plos Biology. 8. PMID 20808760 DOI: 10.1371/Journal.Pbio.1000457  0.624
2010 Mehlitz A, Banhart S, Mäurer AP, Kaushansky A, Gordus AG, Zielecki J, Macbeath G, Meyer TF. Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. The Journal of Cell Biology. 190: 143-57. PMID 20624904 DOI: 10.1083/Jcb.200909095  0.814
2010 Kaushansky A, Allen JE, Gordus A, Stiffler MA, Karp ES, Chang BH, MacBeath G. Quantifying protein-protein interactions in high throughput using protein domain microarrays. Nature Protocols. 5: 773-90. PMID 20360771 DOI: 10.1038/Nprot.2010.36  0.736
2009 Gordus A, Krall JA, Beyer EM, Kaushansky A, Wolf-Yadlin A, Sevecka M, Chang BH, Rush J, MacBeath G. Linear combinations of docking affinities explain quantitative differences in RTK signaling. Molecular Systems Biology. 5: 235. PMID 19156127 DOI: 10.1038/Msb.2008.72  0.758
2009 Jung AS, Kaushansky A, Kaushansky K. Functional Interaction Between c-MPL and Tensin2: A Novel and Potentially Important Pathway in Thrombopoietin Mediated Signaling. Blood. 114: 3609-3609. DOI: 10.1182/Blood.V114.22.3609.3609  0.378
2008 Kaushansky A, Gordus A, Budnik BA, Lane WS, Rush J, MacBeath G. System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chemistry & Biology. 15: 808-17. PMID 18721752 DOI: 10.1016/J.Chembiol.2008.07.006  0.769
2008 Kaushansky A, Gordus A, Chang B, Rush J, MacBeath G. A quantitative study of the recruitment potential of all intracellular tyrosine residues on EGFR, FGFR1 and IGF1R. Molecular Biosystems. 4: 643-53. PMID 18493663 DOI: 10.1039/B801018H  0.775
2000 Miyakawa Y, Drachman JG, Gallis B, Kaushansky A, Kaushansky K. A structure-function analysis of serine/threonine phosphorylation of the thrombopoietin receptor, c-Mpl Journal of Biological Chemistry. 275: 32214-32219. PMID 10918061 DOI: 10.1074/Jbc.M005080200  0.314
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