Philip A. Romero, Ph.D. - Publications

Affiliations: 
2012 Biochemistry and Molecular Biophysics California Institute of Technology, Pasadena, CA 
Area:
Protein engineering, directed protein evolution, structure-guided protein recombination, biocatalysis, biofuels

15 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 D'Costa S, Hinds EC, Freschlin CR, Song H, Romero PA. Inferring protein fitness landscapes from laboratory evolution experiments. Plos Computational Biology. 19: e1010956. PMID 36857380 DOI: 10.1371/journal.pcbi.1010956  0.33
2020 Song H, Bremer BJ, Hinds EC, Raskutti G, Romero PA. Inferring Protein Sequence-Function Relationships with Large-Scale Positive-Unlabeled Learning. Cell Systems. PMID 33212013 DOI: 10.1016/j.cels.2020.10.007  0.31
2017 Ojala DS, Sun S, Santiago-Ortiz JL, Shapiro MG, Romero PA, Schaffer DV. In Vivo Selection of a Computationally Designed SCHEMA AAV Library Yields a Novel Variant for Infection of Adult Neural Stem Cells in the SVZ. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28988711 DOI: 10.1016/J.Ymthe.2017.09.006  0.317
2015 Romero PA, Tran TM, Abate AR. Dissecting enzyme function with microfluidic-based deep mutational scanning. Proceedings of the National Academy of Sciences of the United States of America. 112: 7159-64. PMID 26040002 DOI: 10.1073/Pnas.1422285112  0.492
2013 Romero PA, Shapiro MG, Arnold FH, Jasanoff A. Directed evolution of protein-based neurotransmitter sensors for MRI. Methods in Molecular Biology (Clifton, N.J.). 995: 193-205. PMID 23494381 DOI: 10.1007/978-1-62703-345-9_14  0.516
2013 Heinzelman P, Romero PA, Arnold FH. Efficient sampling of SCHEMA chimera families to identify useful sequence elements. Methods in Enzymology. 523: 351-68. PMID 23422438 DOI: 10.1016/B978-0-12-394292-0.00016-3  0.552
2013 Romero PA, Krause A, Arnold FH. Navigating the protein fitness landscape with Gaussian processes. Proceedings of the National Academy of Sciences of the United States of America. 110: E193-201. PMID 23277561 DOI: 10.1073/Pnas.1215251110  0.591
2013 Smith MA, Romero PA, Wu T, Brustad EM, Arnold FH. Chimeragenesis of distantly-related proteins by noncontiguous recombination. Protein Science : a Publication of the Protein Society. 22: 231-8. PMID 23225662 DOI: 10.1002/Pro.2202  0.709
2012 Romero PA, Arnold FH. Random field model reveals structure of the protein recombinational landscape. Plos Computational Biology. 8: e1002713. PMID 23055915 DOI: 10.1371/Journal.Pcbi.1002713  0.621
2012 Komor RS, Romero PA, Xie CB, Arnold FH. Highly thermostable fungal cellobiohydrolase I (Cel7A) engineered using predictive methods. Protein Engineering, Design & Selection : Peds. 25: 827-33. PMID 22961332 DOI: 10.1093/Protein/Gzs058  0.632
2012 Romero PA, Stone E, Lamb C, Chantranupong L, Krause A, Miklos AE, Hughes RA, Fechtel B, Ellington AD, Arnold FH, Georgiou G. SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis. Acs Synthetic Biology. 1: 221-8. PMID 22737599 DOI: 10.1021/Sb300014T  0.594
2010 Heinzelman P, Komor R, Kanaan A, Romero P, Yu X, Mohler S, Snow C, Arnold F. Efficient screening of fungal cellobiohydrolase class i enzymes for thermostabilizing sequence blocks by SCHEMA structure-guided recombination Protein Engineering, Design and Selection. 23: 871-880. PMID 20847102 DOI: 10.1093/Protein/Gzq063  0.637
2010 Shapiro MG, Westmeyer GG, Romero PA, Szablowski JO, Küster B, Shah A, Otey CR, Langer R, Arnold FH, Jasanoff A. Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine. Nature Biotechnology. 28: 264-70. PMID 20190737 DOI: 10.1038/Nbt.1609  0.456
2009 Romero PA, Arnold FH. Exploring protein fitness landscapes by directed evolution. Nature Reviews. Molecular Cell Biology. 10: 866-76. PMID 19935669 DOI: 10.1038/Nrm2805  0.565
2007 Bloom JD, Romero PA, Lu Z, Arnold FH. Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution. Biology Direct. 2: 17. PMID 17598905 DOI: 10.1186/1745-6150-2-17  0.664
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