Zhao-Xun Liang, Ph.D. - Publications

Affiliations: 
UC Berkeley College of Chemistry 
 2001 Northwestern University, Evanston, IL 
 2005- Nanyang Technological University, Singapore, Singapore 
Area:
Biochemistry, Chemical Biology

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Cheng T, Cheang QW, Xu L, Sheng S, Li Z, Shi Y, Zhang H, Pang LM, Liu DX, Yang L, Liang ZX, Wang J. A PilZ Domain Protein Interacts with the Transcriptional Regulator HinK to Regulate Type VI Secretion System in Pseudomonas aeruginosa. The Journal of Biological Chemistry. 105741. PMID 38340793 DOI: 10.1016/j.jbc.2024.105741  0.309
2019 Xin L, Zeng Y, Sheng S, Chea RA, Liu Q, Li HY, Yang L, Xu L, Chiam KH, Liang ZX. Regulation of flagellar motor switching by c-di-GMP phosphodiesterases in . The Journal of Biological Chemistry. PMID 31350333 DOI: 10.1074/Jbc.Ra119.009009  0.312
2019 Sheng S, Xin L, Yam JKH, Salido MM, Khong NZJ, Liu Q, Chea RA, Li HY, Yang L, Liang ZX, Xu L. The MapZ-Mediated Methylation of Chemoreceptors Contributes to Pathogenicity of . Frontiers in Microbiology. 10: 67. PMID 30804897 DOI: 10.3389/Fmicb.2019.00067  0.332
2019 Cheang QW, Xin L, Chea RYF, Liang ZX. Emerging paradigms for PilZ domain-mediated C-di-GMP signaling. Biochemical Society Transactions. PMID 30710060 DOI: 10.1042/Bst20180543  0.454
2017 Yan XF, Xin L, Yen JT, Zeng Y, Jin S, Cheang QW, Fong RACY, Chiam KH, Liang ZX, Gao YG. Structural Analyses Unravel the Molecular Mechanism of Cyclic di-GMP Regulation of Bacterial Chemotaxis via a PilZ Adaptor Protein. The Journal of Biological Chemistry. PMID 29146598 DOI: 10.1074/Jbc.M117.815704  0.446
2017 Liu C, Liew CW, Wong YH, Tan ST, Poh WH, Manimekalai SMS, Rajan S, Xin L, Liang ZX, Grüber G, Rice SA, Lescar J. Insights into biofilm dispersal regulation from the crystal structure of the PAS-GGDEF-EAL region of RbdA from Pseudomonas aeruginosa. Journal of Bacteriology. PMID 29109186 DOI: 10.1128/Jb.00515-17  0.432
2017 Venkataramani P, Liang ZX. Enzymatic Production of c-di-GMP Using a Thermophilic Diguanylate Cyclase. Methods in Molecular Biology (Clifton, N.J.). 1657: 11-22. PMID 28889282 DOI: 10.1007/978-1-4939-7240-1_2  0.375
2017 Chin JSF, Sinha S, Nalaparaju A, Yam JKH, Qin Z, Ma L, Liang Z, Lu L, Bhattacharjya S, Yang L. Pseudomonas aeruginosa Psl Exopolysaccharide Interacts with the Antimicrobial Peptide LG21 Water. 9: 681. DOI: 10.3390/W9090681  0.316
2016 Römling U, Liang ZX, Dow JM. Progress in understanding of the molecular basis underlying functional diversification of cyclic di-nucleotide turnover proteins. Journal of Bacteriology. PMID 28031279 DOI: 10.1128/Jb.00790-16  0.426
2016 Xu L, Xin L, Zeng Y, Yam JK, Ding Y, Venkataramani P, Cheang QW, Yang X, Tang X, Zhang LH, Chiam KH, Yang L, Liang ZX. A cyclic di-GMP-binding adaptor protein interacts with a chemotaxis methyltransferase to control flagellar motor switching. Science Signaling. 9: ra102. PMID 27811183 DOI: 10.1126/Scisignal.Aaf7584  0.416
2016 Xu L, Venkataramani P, Ding Y, Liu Y, Deng Y, Yong GL, Xin L, Ye R, Zhang L, Yang L, Liang ZX. A Cyclic di-GMP-binding Adaptor Protein Interacts with Histidine Kinase to Regulate Two-Component Signaling. The Journal of Biological Chemistry. PMID 27231351 DOI: 10.1074/Jbc.M116.730887  0.433
2016 Pham TH, Liang ZX, Marcellin E, Turner MS. Replenishing the cyclic-di-AMP pool: regulation of diadenylate cyclase activity in bacteria. Current Genetics. PMID 27074767 DOI: 10.1007/S00294-016-0600-8  0.414
2016 Zhang SY, Wu JH, Zhou JW, Liang Z, Qiu QY, Xu T, Zhang MZ, Zhong CK, Jiang W, Zhang YH. Overweight, resting heart rate, and prediabetes/diabetes: A population-based prospective cohort study among Inner Mongolians in China. Scientific Reports. 6: 23939. PMID 27029423 DOI: 10.1038/srep23939  0.371
2016 Deng QF, Sun X, Liang ZF, Zhang ZQ, Yu DX, Zhong CY. Cigarette smoke extract induces the proliferation of normal human urothelial cells through the NF-κB pathway. Oncology Reports. PMID 26883573 DOI: 10.3892/Or.2016.4623  0.392
2016 Zhu M, Huang C, Ma X, Wu R, Zhu W, Li X, Liang Z, Deng F, Zhu J, Xie W, Yang X, Jiang Y, Wang S, Wu J, Geng S, et al. Modulation of miR-19 in Aluminum-Induced Neural Cell Apoptosis. Journal of Alzheimer's Disease : Jad. PMID 26836165 DOI: 10.3233/Jad-150763  0.399
2016 Deng QF, Sun X, Zhao L, Geng H, Liang ZF, Zhang ZQ, Yu DX, Zhong CY. Curcumin reverse cigarette smoke extract-induced human bladder epithelial-mesenchymal transition via suppresses NF-κB signaling in vitro International Journal of Clinical and Experimental Medicine. 9: 5031-5044.  0.426
2015 Chin KH, Liang JM, Yang JG, Shih MS, Tu ZL, Wang YC, Sun XH, Hu NJ, Liang ZX, Dow JM, Ryan RP, Chou SH. Structural Insights into the Distinct Binding Mode of Cyclic di-AMP with SaCpaA-RCK. Biochemistry. PMID 26171638 DOI: 10.1021/Acs.Biochem.5B00633  0.419
2015 Geng S, Zhu W, Xie C, Li X, Wu J, Liang Z, Xie W, Zhu J, Huang C, Zhu M, Wu R, Zhong C. Medium-chain triglyceride ameliorates insulin resistance and inflammation in high fat diet-induced obese mice. European Journal of Nutrition. PMID 25911003 DOI: 10.1007/S00394-015-0907-0  0.376
2015 Liang ZX. The expanding roles of c-di-GMP in the biosynthesis of exopolysaccharides and secondary metabolites. Natural Product Reports. 32: 663-83. PMID 25666534 DOI: 10.1039/C4Np00086B  0.342
2015 Ribeiro AJM, Yang L, Ramos MJ, Fernandes PA, Liang ZX, Hirao H. Insight into enzymatic nitrile reduction: QM/MM study of the catalytic mechanism of QueF nitrile reductase Acs Catalysis. 5: 3740-3751. DOI: 10.1021/Acscatal.5B00528  0.301
2015 Sun X, Deng QF, Liang ZF, Zhang ZQ, Zhao L, Geng H, Xie DD, Wang Y, Yu DX, Zhong CY. Curcumin reverses benzidine-induced cell proliferation by suppressing ERK1/2 pathway in human bladder cancer T24 cells Experimental and Toxicologic Pathology. DOI: 10.1016/j.etp.2015.12.003  0.383
2014 Deepthi A, Liew CW, Liang ZX, Swaminathan K, Lescar J. Structure of a diguanylate cyclase from Thermotoga maritima: insights into activation, feedback inhibition and thermostability. Plos One. 9: e110912. PMID 25360685 DOI: 10.1371/Journal.Pone.0110912  0.402
2014 Soehano I, Yang L, Ding F, Sun H, Low ZJ, Liu X, Liang ZX. Insights into the programmed ketoreduction of partially reducing polyketide synthases: stereo- and substrate-specificity of the ketoreductase domain. Organic & Biomolecular Chemistry. 12: 8542-9. PMID 25238086 DOI: 10.1039/C4Ob01777C  0.348
2014 Wigren E, Liang ZX, Römling U. Finally! The structural secrets of a HD-GYP phosphodiesterase revealed. Molecular Microbiology. 91: 1-5. PMID 24236493 DOI: 10.1111/Mmi.12463  0.422
2014 Yang L, Koh SL, Sutton PW, Liang ZX. Nitrile reductase as a biocatalyst: Opportunities and challenges Catalysis Science and Technology. 4: 2871-2876. DOI: 10.1039/C4Cy00646A  0.31
2013 Ahmad I, Wigren E, Le Guyon S, Vekkeli S, Blanka A, El Mouali Y, Anwar N, Chuah ML, Lünsdorf H, Frank R, Rhen M, Liang ZX, Lindqvist Y, Römling U. The EAL-like protein STM1697 regulates virulence phenotypes, motility and biofilm formation in Salmonella typhimurium. Molecular Microbiology. 90: 1216-32. PMID 24127899 DOI: 10.1111/Mmi.12428  0.415
2013 Chin KH, Tu ZL, Su YC, Yu YJ, Chen HC, Lo YC, Chen CP, Barber GN, Chuah ML, Liang ZX, Chou SH. Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING. Acta Crystallographica. Section D, Biological Crystallography. 69: 352-66. PMID 23519410 DOI: 10.1107/S0907444912047269  0.32
2013 Tan E, Rao F, Pasunooti S, Pham TH, Soehano I, Turner MS, Liew CW, Lescar J, Pervushin K, Liang ZX. Solution structure of the PAS domain of a thermophilic YybT protein homolog reveals a potential ligand-binding site. The Journal of Biological Chemistry. 288: 11949-59. PMID 23504327 DOI: 10.1074/Jbc.M112.437764  0.658
2013 Ho CL, Chong KS, Oppong JA, Chuah ML, Tan SM, Liang ZX. Visualizing the perturbation of cellular cyclic di-GMP levels in bacterial cells. Journal of the American Chemical Society. 135: 566-9. PMID 23289502 DOI: 10.1021/Ja310497X  0.708
2012 Wang YC, Chin KH, Chuah ML, Liang ZX, Chou SH. Crystallization and preliminary X-ray diffraction studies of Xanthomonas campestris PNPase in the presence of c-di-GMP. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 1247-50. PMID 23027759 DOI: 10.1107/S1744309112036202  0.34
2012 Lim J, Sun H, Fan JS, Hameed IF, Lescar J, Liang ZX, Yang D. Rigidifying acyl carrier protein domain in iterative type I PKS CalE8 does not affect its function. Biophysical Journal. 103: 1037-44. PMID 23009853 DOI: 10.1016/J.Bpj.2012.08.006  0.377
2012 Qi Y, Xu L, Dong X, Yau YH, Ho CL, Koh SL, Shochat SG, Chou SH, Tang K, Liang ZX. Functional divergence of FimX in PilZ binding and type IV pilus regulation. Journal of Bacteriology. 194: 5922-31. PMID 22942245 DOI: 10.1128/Jb.00767-12  0.721
2012 Su YC, Tu ZL, Yang CY, Chin KH, Chuah ML, Liang ZX, Chou SH. Crystallization studies of the murine c-di-GMP sensor protein STING. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 906-10. PMID 22869119 DOI: 10.1107/S1744309112024372  0.393
2012 Sun H, Ho CL, Ding F, Soehano I, Liu XW, Liang ZX. Synthesis of (R)-mellein by a partially reducing iterative polyketide synthase. Journal of the American Chemical Society. 134: 11924-7. PMID 22793256 DOI: 10.1021/Ja304905E  0.708
2012 Chen MW, Kotaka M, Vonrhein C, Bricogne G, Rao F, Chuah ML, Svergun D, Schneider G, Liang ZX, Lescar J. Structural insights into the regulatory mechanism of the response regulator RocR from Pseudomonas aeruginosa in cyclic Di-GMP signaling. Journal of Bacteriology. 194: 4837-46. PMID 22753070 DOI: 10.1128/Jb.00560-12  0.678
2012 Liew CW, Nilsson M, Chen MW, Sun H, Cornvik T, Liang ZX, Lescar J. Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis. The Journal of Biological Chemistry. 287: 23203-15. PMID 22589546 DOI: 10.1074/Jbc.M112.362210  0.403
2012 Liao YT, Chin KH, Kuo WT, Chuah ML, Liang ZX, Chou SH. Crystallization and preliminary X-ray diffraction characterization of the XccFimX(EAL)-c-di-GMP and XccFimX(EAL)-c-di-GMP-XccPilZ complexes from Xanthomonas campestris. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 301-5. PMID 22442228 DOI: 10.1107/S1744309112000590  0.412
2011 Yang CY, Chin KH, Chuah ML, Liang ZX, Wang AH, Chou SH. The structure and inhibition of a GGDEF diguanylate cyclase complexed with (c-di-GMP)(2) at the active site. Acta Crystallographica. Section D, Biological Crystallography. 67: 997-1008. PMID 22120736 DOI: 10.1107/S090744491104039X  0.46
2011 Ho CL, Koh SL, Chuah ML, Luo Z, Tan WJ, Low DK, Liang ZX. Rational design of fluorescent biosensor for cyclic di-GMP. Chembiochem : a European Journal of Chemical Biology. 12: 2753-8. PMID 22021215 DOI: 10.1002/Cbic.201100557  0.705
2011 Wilksch JJ, Yang J, Clements A, Gabbe JL, Short KR, Cao H, Cavaliere R, James CE, Whitchurch CB, Schembri MA, Chuah ML, Liang ZX, Wijburg OL, Jenney AW, Lithgow T, et al. MrkH, a novel c-di-GMP-dependent transcriptional activator, controls Klebsiella pneumoniae biofilm formation by regulating type 3 fimbriae expression. Plos Pathogens. 7: e1002204. PMID 21901098 DOI: 10.1371/Journal.Ppat.1002204  0.398
2011 Lim J, Kong R, Murugan E, Ho CL, Liang ZX, Yang D. Solution structures of the acyl carrier protein domain from the highly reducing type I iterative polyketide synthase CalE8. Plos One. 6: e20549. PMID 21674045 DOI: 10.1371/Journal.Pone.0020549  0.732
2011 Rao F, Ji Q, Soehano I, Liang ZX. Unusual heme-binding PAS domain from YybT family proteins. Journal of Bacteriology. 193: 1543-51. PMID 21257773 DOI: 10.1128/Jb.01364-10  0.658
2011 Qi Y, Chuah ML, Dong X, Xie K, Luo Z, Tang K, Liang ZX. Binding of cyclic diguanylate in the non-catalytic EAL domain of FimX induces a long-range conformational change. The Journal of Biological Chemistry. 286: 2910-7. PMID 21098028 DOI: 10.1074/Jbc.M110.196220  0.447
2011 Rao F, See RY, Zhang D, Toh DC, Ji Q, Liang ZX. YybT is a signaling protein that contains a cyclic dinucleotide phosphodiesterase domain and a GGDEF domain with ATPase activity (Journal of Biological Chemistry (2010) 285, (473-482)) Journal of Biological Chemistry. 286: 29441. DOI: 10.1074/jbc.A109.040238  0.61
2011 Ho CL, Koh SL, Chuah MLC, Luo Z, Tan WJ, Low DKS, Liang Z. Cover Picture: Rational Design of Fluorescent Biosensor for Cyclic di-GMP (ChemBioChem 18/2011) Chembiochem. 12: 2705-2705. DOI: 10.1002/Cbic.201190085  0.666
2010 Liew CW, Sharff A, Kotaka M, Kong R, Sun H, Qureshi I, Bricogne G, Liang ZX, Lescar J. Induced-fit upon ligand binding revealed by crystal structures of the hot-dog fold thioesterase in dynemicin biosynthesis. Journal of Molecular Biology. 404: 291-306. PMID 20888341 DOI: 10.1016/J.Jmb.2010.09.041  0.377
2010 Murugan E, Kong R, Sun H, Rao F, Liang ZX. Expression, purification and characterization of the acyl carrier protein phosphodiesterase from Pseudomonas Aeruginosa. Protein Expression and Purification. 71: 132-8. PMID 20064615 DOI: 10.1016/J.Pep.2010.01.007  0.627
2010 Rao F, See RY, Zhang D, Toh DC, Ji Q, Liang ZX. YybT is a signaling protein that contains a cyclic dinucleotide phosphodiesterase domain and a GGDEF domain with ATPase activity. The Journal of Biological Chemistry. 285: 473-82. PMID 19901023 DOI: 10.1074/Jbc.M109.040238  0.674
2010 Pasunooti S, Surya W, Tan SN, Liang ZX. Sol-gel immobilization of a thermophilic diguanylate cyclase for enzymatic production of cyclic-di-GMP Journal of Molecular Catalysis B: Enzymatic. 67: 98-103. DOI: 10.1016/J.Molcatb.2010.07.012  0.345
2009 Kotaka M, Dutta S, Lee HC, Lim MJ, Wong Y, Rao F, Mitchell EP, Liang ZX, Lescar J. Expression, purification and preliminary crystallographic analysis of Pseudomonas aeruginosa RocR protein. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 1035-8. PMID 19851016 DOI: 10.1107/S1744309109034526  0.575
2009 Qi Y, Rao F, Luo Z, Liang ZX. A flavin cofactor-binding PAS domain regulates c-di-GMP synthesis in AxDGC2 from Acetobacter xylinum. Biochemistry. 48: 10275-85. PMID 19785462 DOI: 10.1021/Bi901121W  0.677
2009 Rao F, Qi Y, Chong HS, Kotaka M, Li B, Li J, Lescar J, Tang K, Liang ZX. The functional role of a conserved loop in EAL domain-based cyclic di-GMP-specific phosphodiesterase. Journal of Bacteriology. 191: 4722-31. PMID 19376848 DOI: 10.1128/Jb.00327-09  0.667
2009 Kotaka M, Kong R, Qureshi I, Ho QS, Sun H, Liew CW, Goh LP, Cheung P, Mu Y, Lescar J, Liang ZX. Structure and catalytic mechanism of the thioesterase CalE7 in enediyne biosynthesis. The Journal of Biological Chemistry. 284: 15739-49. PMID 19357082 DOI: 10.1074/Jbc.M809669200  0.385
2009 Rao F, Pasunooti S, Ng Y, Zhuo W, Lim L, Liu AW, Liang ZX. Enzymatic synthesis of c-di-GMP using a thermophilic diguanylate cyclase. Analytical Biochemistry. 389: 138-42. PMID 19328769 DOI: 10.1016/J.Ab.2009.03.031  0.646
2008 Kong R, Goh LP, Liew CW, Ho QS, Murugan E, Li B, Tang K, Liang ZX. Characterization of a carbonyl-conjugated polyene precursor in 10-membered enediyne biosynthesis. Journal of the American Chemical Society. 130: 8142-3. PMID 18529057 DOI: 10.1021/Ja8019643  0.305
2008 Rao F, Yang Y, Qi Y, Liang ZX. Catalytic mechanism of cyclic di-GMP-specific phosphodiesterase: a study of the EAL domain-containing RocR from Pseudomonas aeruginosa. Journal of Bacteriology. 190: 3622-31. PMID 18344366 DOI: 10.1128/Jb.00165-08  0.669
2008 Murugan E, Liang ZX. Evidence for a novel phosphopantetheinyl transferase domain in the polyketide synthase for enediyne biosynthesis. Febs Letters. 582: 1097-103. PMID 18319060 DOI: 10.1016/J.Febslet.2008.02.061  0.421
2006 Liang Z, Tsigos I, Bouriotis aV, Klinman JP. Impact of Protein Flexibility on Hydride-Transfer Parameters in Thermophilic and Psychrophilic Alcohol Dehydrogenases [J. Am. Chem. Soc. 2004, 126, 9500−9501]. Journal of the American Chemical Society. 128: 3467-3467. DOI: 10.1021/Ja069955T  0.506
2004 Liang ZX, Klinman JP. Structural bases of hydrogen tunneling in enzymes: Progress and puzzles Current Opinion in Structural Biology. 14: 648-655. PMID 15582387 DOI: 10.1016/J.Sbi.2004.10.008  0.511
2004 Liang ZX, Tsigos I, Lee T, Bouriotis V, Resing KA, Ahn NG, Klinman JP. Evidence for increased local flexibility in psychrophilic alcohol dehydrogenase relative to its thermophilic homologue Biochemistry. 43: 14676-14683. PMID 15544338 DOI: 10.1021/Bi049004X  0.668
2004 Liang ZX, Tsigos I, Bouriotis V, Klinman JP. Impact of protein flexibility on hydride-transfer parameters in thermophilic and psychrophilic alcohol dehydrogenases Journal of the American Chemical Society. 126: 9500-9501. PMID 15291528 DOI: 10.1021/Ja047087Z  0.534
2004 Liang ZX, Lee T, Resing KA, Ahn NG, Klinman JP. Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase Proceedings of the National Academy of Sciences of the United States of America. 101: 9556-9561. PMID 15210941 DOI: 10.1073/Pnas.0403337101  0.689
2004 Ceccarelli C, Liang ZX, Strickler M, Prehna G, Goldstein BM, Klinman JP, Bahnson BJ. Crystal Structure and Amide H/D Exchange of Binary Complexes of Alcohol Dehydrogenase from Bacillus stearothermophilus: Insight into Thermostability and Cofactor Binding Biochemistry. 43: 5266-5277. PMID 15122892 DOI: 10.1021/Bi049736P  0.718
2004 Liang ZX, Kurnikov IV, Nocek JM, Mauk AG, Beratan DN, Hoffman BM. Dynamic docking and electron-transfer between cytochrome b5 and a suite of myoglobin surface-charge mutants. Introduction of a functional-docking algorithm for protein-protein complexes. Journal of the American Chemical Society. 126: 2785-98. PMID 14995196 DOI: 10.1021/Ja038163L  0.399
2002 Liang ZX, Jiang M, Ning Q, Hoffman BM. Dynamic docking and electron transfer between myoglobin and cytochrome b(5). Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 7: 580-8. PMID 12072963 DOI: 10.1007/S00775-001-0332-0  0.389
2002 Liang ZX, Nocek JM, Huang K, Hayes RT, Kurnikov IV, Beratan DN, Hoffman BM. Dynamic docking and electron transfer between Zn-myoglobin and cytochrome b(5). Journal of the American Chemical Society. 124: 6849-59. PMID 12059205 DOI: 10.1021/Ja0127032  0.404
2000 Liang ZX, Nocek JM, Kurnikov IV, Beratan DN, Hoffman BM. Electrostatic control of electron transfer between myoglobin and cytochrome b5: Effect of methylating the heme propionates of Zn-myoglobin [16] Journal of the American Chemical Society. 122: 3552-3553. DOI: 10.1021/Ja993951P  0.307
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