Walter Colli, M. D., Ph.D. - Publications

Affiliations: 
1966- Biochemistry University of São Paulo, São Paulo, São Paulo, Brazil 
Area:
Parasitology, Biochemistry, Trypanosoma cruzi

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Magalhães RDM, Mattos EC, Rozanski A, Galante PAF, Palmisano G, Cruz AK, Colli W, Camargo AA, Alves MJM. Global changes in nitration levels and DNA binding profile of Trypanosoma cruzi histones induced by incubation with host extracellular matrix. Plos Neglected Tropical Diseases. 14: e0008262. PMID 32469928 DOI: 10.1371/Journal.Pntd.0008262  0.318
2019 Mattos EC, Canuto G, Varón NCM, Magalhães RDM, Crozier TWM, Lamont DJ, Tavares MFM, Colli W, Ferguson MAJ, Alves MJM. Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix. Plos Neglected Tropical Diseases. 13: e0007103. PMID 30726203 DOI: 10.1371/Journal.Pntd.0007103  0.368
2016 Alves MJ, Kawahara R, Viner R, Colli W, Mattos EC, Thaysen-Andersen M, Larsen MR, Palmisano G. Comprehensive glycoprofiling of the epimastigote and trypomastigote stages of Trypanosoma cruzi. Journal of Proteomics. PMID 27318177 DOI: 10.1016/J.Jprot.2016.05.034  0.339
2015 Teixeira AA, de Vasconcelos Vde C, Colli W, Alves MJ, Giordano RJ. Trypanosoma cruzi Binds to Cytokeratin through Conserved Peptide Motifs Found in the Laminin-G-Like Domain of the gp85/Trans-sialidase Proteins. Plos Neglected Tropical Diseases. 9: e0004099. PMID 26398185 DOI: 10.1371/Journal.Pntd.0004099  0.355
2015 Pereira M, Soares C, Canuto GA, Tavares MF, Colli W, Alves MJ. Down regulation of NO signaling in Trypanosoma cruzi upon parasite-extracellular matrix interaction: changes in protein modification by nitrosylation and nitration. Plos Neglected Tropical Diseases. 9: e0003683. PMID 25856423 DOI: 10.1371/Journal.Pntd.0003683  0.304
2015 Khusal KG, Tonelli RR, Mattos EC, Soares CO, Di Genova BM, Juliano MA, Urias U, Colli W, Alves MJ. Prokineticin receptor identified by phage display is an entry receptor for Trypanosoma cruzi into mammalian cells. Parasitology Research. 114: 155-65. PMID 25324134 DOI: 10.1007/S00436-014-4172-6  0.355
2014 Soares CO, Dias CP, Colli W, Manso Alves MJ. Nitric oxide affects trypomastigote to amastigote differentiation in Trypanosoma cruzi. Free Radical Biology & Medicine. 75: S50. PMID 26461401 DOI: 10.1016/J.Freeradbiomed.2014.10.817  0.36
2014 Mattos EC, Tonelli RR, Colli W, Alves MJ. The Gp85 surface glycoproteins from Trypanosoma cruzi. Sub-Cellular Biochemistry. 74: 151-80. PMID 24264245 DOI: 10.1007/978-94-007-7305-9_7  0.352
2012 Tonelli RR, Colli W, Alves MJ. Selection of binding targets in parasites using phage-display and aptamer libraries in vivo and in vitro. Frontiers in Immunology. 3: 419. PMID 23316203 DOI: 10.3389/Fimmu.2012.00419  0.351
2012 Mattos EC, Schumacher RI, Colli W, Alves MJ. Adhesion of Trypanosoma cruzi trypomastigotes to fibronectin or laminin modifies tubulin and paraflagellar rod protein phosphorylation. Plos One. 7: e46767. PMID 23056443 DOI: 10.1371/Journal.Pone.0046767  0.347
2012 Soares CO, Colli W, Bechara EJ, Alves MJ. 1,4-Diamino-2-butanone, a putrescine analogue, promotes redox imbalance in Trypanosoma cruzi and mammalian cells. Archives of Biochemistry and Biophysics. 528: 103-10. PMID 23036870 DOI: 10.1016/J.Abb.2012.09.005  0.342
2012 Torrecilhas AC, Schumacher RI, Alves MJ, Colli W. Vesicles as carriers of virulence factors in parasitic protozoan diseases. Microbes and Infection / Institut Pasteur. 14: 1465-74. PMID 22892602 DOI: 10.1016/J.Micinf.2012.07.008  0.345
2011 Tonelli RR, Torrecilhas AC, Jacysyn JF, Juliano MA, Colli W, Alves MJ. In vivo infection by Trypanosoma cruzi: the conserved FLY domain of the gp85/trans-sialidase family potentiates host infection. Parasitology. 138: 481-92. PMID 21040619 DOI: 10.1017/S0031182010001411  0.335
2010 Tonelli RR, Giordano RJ, Barbu EM, Torrecilhas AC, Kobayashi GS, Langley RR, Arap W, Pasqualini R, Colli W, Alves MJ. Role of the gp85/trans-sialidases in Trypanosoma cruzi tissue tropism: preferential binding of a conserved peptide motif to the vasculature in vivo. Plos Neglected Tropical Diseases. 4: e864. PMID 21072227 DOI: 10.1371/Journal.Pntd.0000864  0.327
2010 Alves MJM, Colli W. Signaling pathways in Trypanosoma cruzi that modulate host cell interaction Open Parasitology Journal. 4: 77-83. DOI: 10.2174/1874421401004010077  0.358
2008 Alves MJ, Colli W. Role of the gp85/trans-sialidase superfamily of glycoproteins in the interaction of Trypanosoma cruzi with host structures. Sub-Cellular Biochemistry. 47: 58-69. PMID 18512341 DOI: 10.1007/978-0-387-78267-6_4  0.337
2007 Alves MJ, Colli W. Trypanosoma cruzi: adhesion to the host cell and intracellular survival. Iubmb Life. 59: 274-9. PMID 17505965 DOI: 10.1080/15216540701200084  0.322
2007 Nogueira NF, Gonzalez MS, Gomes JE, de Souza W, Garcia ES, Azambuja P, Nohara LL, Almeida IC, Zingales B, Colli W. Trypanosoma cruzi: involvement of glycoinositolphospholipids in the attachment to the luminal midgut surface of Rhodnius prolixus. Experimental Parasitology. 116: 120-8. PMID 17306256 DOI: 10.1016/J.Exppara.2006.12.014  0.351
2007 Mielniczki-Pereira AA, Chiavegatto CM, López JA, Colli W, Alves MJ, Gadelha FR. Trypanosoma cruzi strains, Tulahuen 2 and Y, besides the difference in resistance to oxidative stress, display differential glucose-6-phosphate and 6-phosphogluconate dehydrogenases activities. Acta Tropica. 101: 54-60. PMID 17214950 DOI: 10.1016/J.Actatropica.2006.12.001  0.303
2007 Magdesian MH, Tonelli RR, Fessel MR, Silveira MS, Schumacher RI, Linden R, Colli W, Alves MJ. A conserved domain of the gp85/trans-sialidase family activates host cell extracellular signal-regulated kinase and facilitates Trypanosoma cruzi infection. Experimental Cell Research. 313: 210-8. PMID 17101128 DOI: 10.1016/J.Yexcr.2006.10.008  0.363
2006 Ferreira AAP, Colli W, Alves MJM, Oliveira DR, Costa PI, Güell AG, Sanz F, Benedetti AV, Yamanaka H. Investigation of the interaction between Tc85-11 protein and antibody anti-T. cruzi by AFM and amperometric measurements Electrochimica Acta. 51: 5046-5052. DOI: 10.1016/J.Electacta.2006.03.061  0.312
2005 Ferreira AA, Colli W, da Costa PI, Yamanaka H. Immunosensor for the diagnosis of Chagas' disease. Biosensors & Bioelectronics. 21: 175-81. PMID 15967366 DOI: 10.1016/J.Bios.2004.08.001  0.306
2005 Canepa GE, Bouvier LA, Urias U, Miranda MR, Colli W, Alves MJ, Pereira CA. Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruzi. Fems Microbiology Letters. 247: 65-71. PMID 15927749 DOI: 10.1016/J.Femsle.2005.04.029  0.315
2005 Silber AM, Colli W, Ulrich H, Alves MJ, Pereira CA. Amino acid metabolic routes in Trypanosoma cruzi: possible therapeutic targets against Chagas' disease. Current Drug Targets. Infectious Disorders. 5: 53-64. PMID 15777198 DOI: 10.2174/1568005053174636  0.338
2004 Marroquin-Quelopana M, Oyama S, Aguiar Pertinhez T, Spisni A, Aparecida Juliano M, Juliano L, Colli W, Alves MJ. Modeling the Trypanosoma cruzi Tc85-11 protein and mapping the laminin-binding site. Biochemical and Biophysical Research Communications. 325: 612-8. PMID 15530437 DOI: 10.1016/J.Bbrc.2004.10.068  0.312
2004 Tonelli RR, Silber AM, Almeida-de-Faria M, Hirata IY, Colli W, Alves MJ. L-proline is essential for the intracellular differentiation of Trypanosoma cruzi. Cellular Microbiology. 6: 733-41. PMID 15236640 DOI: 10.1111/J.1462-5822.2004.00397.X  0.329
2004 Bertello LE, Alves MJ, Colli W, de Lederkremer RM. Inositolphosphoceramide is not a substrate for the first steps in the biosynthesis of glycoinositolphospholipids in Trypanosoma cruzi. Molecular and Biochemical Parasitology. 133: 71-80. PMID 14668014 DOI: 10.1016/J.Molbiopara.2003.09.007  0.308
2004 Finzi JK, Chiavegatto CW, Corat KF, Lopez JA, Cabrera OG, Mielniczki-Pereira AA, Colli W, Alves MJ, Gadelha FR. Trypanosoma cruzi response to the oxidative stress generated by hydrogen peroxide. Molecular and Biochemical Parasitology. 133: 37-43. PMID 14668010 DOI: 10.1016/J.Molbiopara.2003.08.011  0.328
2002 Ulrich H, Magdesian MH, Alves MJ, Colli W. In vitro selection of RNA aptamers that bind to cell adhesion receptors of Trypanosoma cruzi and inhibit cell invasion. The Journal of Biological Chemistry. 277: 20756-62. PMID 11919187 DOI: 10.1074/Jbc.M111859200  0.345
2001 Oliveira MF, Bijovsky AT, Carvalho TU, de Souza W, Alves MJ, Colli W. A monoclonal antibody to Trypanosoma cruzi trypomastigotes recognizes a myosin tail epitope. Parasitology Research. 87: 1043-9. PMID 11763437 DOI: 10.1007/S004360100465  0.318
2001 Magdesian MH, Giordano R, Ulrich H, Juliano MA, Juliano L, Schumacher RI, Colli W, Alves MJ. Infection by Trypanosoma cruzi. Identification of a parasite ligand and its host cell receptor. The Journal of Biological Chemistry. 276: 19382-9. PMID 11278913 DOI: 10.1074/Jbc.M011474200  0.352
2001 Ulrich H, Alves MJ, Colli W. RNA and DNA aptamers as potential tools to prevent cell adhesion in disease. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Mã©Dicas E Biolã³Gicas / Sociedade Brasileira De Biofã­Sica ... [Et Al.]. 34: 295-300. PMID 11262579 DOI: 10.1590/S0100-879X2001000300002  0.321
2000 Lopez JA, Carvalho TU, de Souza W, Flohé L, Guerrero SA, Montemartini M, Kalisz HM, Nogoceke E, Singh M, Alves MJ, Colli W. Evidence for a trypanothione-dependent peroxidase system in Trypanosoma cruzi. Free Radical Biology & Medicine. 28: 767-72. PMID 10754272 DOI: 10.1016/S0891-5849(00)00159-3  0.323
2000 Agusti R, Couto AS, Alves MJ, Colli W, Lederkremer RM. Lipids shed into the culture medium by trypomastigotes of Trypanosoma cruzi. MemóRias Do Instituto Oswaldo Cruz. 95: 97-102. PMID 10656713 DOI: 10.1590/S0074-02762000000100016  0.339
2000 Bertello LE, Alves MJ, Colli W, de Lederkremer RM. Evidence for phospholipases from Trypanosoma cruzi active on phosphatidylinositol and inositolphosphoceramide. The Biochemical Journal. 345: 77-84. PMID 10600641 DOI: 10.1042/Bj3450077  0.338
1999 Colli W, Alves MJ. Relevant glycoconjugates on the surface of Trypanosoma cruzi. MemóRias Do Instituto Oswaldo Cruz. 94: 37-49. PMID 10677690 DOI: 10.1590/S0074-02761999000700004  0.33
1999 Almeida-de-Faria M, Freymüller E, Colli W, Alves MJ. Trypanosoma cruzi: characterization of an intracellular epimastigote-like form. Experimental Parasitology. 92: 263-74. PMID 10425154 DOI: 10.1006/Expr.1999.4423  0.372
1999 Giordano R, Fouts DL, Tewari D, Colli W, Manning JE, Alves MJ. Cloning of a surface membrane glycoprotein specific for the infective form of Trypanosoma cruzi having adhesive properties to laminin. The Journal of Biological Chemistry. 274: 3461-8. PMID 9920891 DOI: 10.1074/Jbc.274.6.3461  0.342
1997 Chung MC, Gonçalves MF, Colli W, Ferreira EI, Miranda MT. Synthesis and in vitro evaluation of potential antichagasic dipeptide prodrugs of primaquine. Journal of Pharmaceutical Sciences. 86: 1127-31. PMID 9344169 DOI: 10.1021/Js970006V  0.32
1997 Uhrig ML, Couto AS, Alves MJ, Colli W, de Lederkremer RM. Trypanosoma cruzi: nitrogenous-base-containing phosphatides in trypomastigote forms--isolation and chemical analysis. Experimental Parasitology. 87: 8-19. PMID 9287953 DOI: 10.1006/Expr.1997.4181  0.336
1996 Uhrig ML, Couto AS, Colli W, de Lederkremer RM. Characterization of inositolphospholipids in Trypanosoma cruzi trypomastigote forms. Biochimica Et Biophysica Acta. 1300: 233-9. PMID 8679689 DOI: 10.1016/0005-2760(96)00021-5  0.327
1996 Abuin G, Couto AS, de Lederkremer RM, Casal OL, Galli C, Colli W, Alves MJ. Trypanosoma cruzi: the Tc-85 surface glycoprotein shed by trypomastigotes bears a modified glycosylphosphatidylinositol anchor. Experimental Parasitology. 82: 290-7. PMID 8631380 DOI: 10.1006/Expr.1996.0036  0.382
1995 de Lederkremer RM, Colli W. Galactofuranose-containing glycoconjugates in trypanosomatids. Glycobiology. 5: 547-52. PMID 8563141 DOI: 10.1093/Glycob/5.6.547  0.333
1995 Ruiz-Moreno L, Bijovsky AT, Pudles J, Alves MJ, Colli W. Trypanosoma cruzi: monoclonal antibody to cytoskeleton recognizes giant proteins of the flagellar attachment zone. Experimental Parasitology. 80: 605-15. PMID 7758541 DOI: 10.1006/Expr.1995.1076  0.325
1995 Bertello LE, Gonçalvez MF, Colli W, de Lederkremer RM. Structural analysis of inositol phospholipids from Trypanosoma cruzi epimastigote forms. The Biochemical Journal. 310: 255-61. PMID 7646454 DOI: 10.1042/Bj3100255  0.331
1994 Giordano R, Chammas R, Veiga SS, Colli W, Alves MJ. An acidic component of the heterogeneous Tc-85 protein family from the surface of Trypanosoma cruzi is a laminin binding glycoprotein. Molecular and Biochemical Parasitology. 65: 85-94. PMID 7935631 DOI: 10.1016/0166-6851(94)90117-1  0.393
1993 Colli W. Trans-sialidase: a unique enzyme activity discovered in the protozoan Trypanosoma cruzi. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 7: 1257-64. PMID 8405811 DOI: 10.1096/Fasebj.7.13.8405811  0.365
1993 de Lederkremer RM, Lima CE, Ramirez MI, Gonçalvez MF, Colli W. Hexadecylpalmitoylglycerol or ceramide is linked to similar glycophosphoinositol anchor-like structures in Trypanosoma cruzi. European Journal of Biochemistry / Febs. 218: 929-36. PMID 8281945 DOI: 10.1111/J.1432-1033.1993.Tb18449.X  0.321
1993 Golgher DB, Colli W, Souto-Padrón T, Zingales B. Galactofuranose-containing glycoconjugates of epimastigote and trypomastigote forms of Trypanosoma cruzi. Molecular and Biochemical Parasitology. 60: 249-64. PMID 8232416 DOI: 10.1016/0166-6851(93)90136-L  0.36
1993 Couto AS, De Lederkremer RM, Colli W, Alves MJ. The glycosylphosphatidylinositol anchor of the trypomastigote-specific Tc-85 glycoprotein from Trypanosoma cruzi. Metabolic-labeling and structural studies. European Journal of Biochemistry / Febs. 217: 597-602. PMID 8223603 DOI: 10.1111/J.1432-1033.1993.Tb18282.X  0.356
1991 Gonçalves MF, Umezawa ES, Katzin AM, de Souza W, Alves MJ, Zingales B, Colli W. Trypanosoma cruzi: shedding of surface antigens as membrane vesicles. Experimental Parasitology. 72: 43-53. PMID 1993464 DOI: 10.1016/0014-4894(91)90119-H  0.305
1990 de Gaspari EN, Umezawa ES, Zingales B, Stolf AM, Colli W, Abrahamsohn IA. Trypanosoma cruzi: serum antibody reactivity to the parasite antigens in susceptible and resistant mice. MemóRias Do Instituto Oswaldo Cruz. 85: 261-70. PMID 2134701 DOI: 10.1590/S0074-02761990000300002  0.315
1989 Abuin G, Colli W, de Souza W, Alves MJ. A surface antigen of Trypanosoma cruzi involved in cell invasion (Tc-85) is heterogeneous in expression and molecular constitution. Molecular and Biochemical Parasitology. 35: 229-37. PMID 2664507 DOI: 10.1016/0166-6851(89)90209-0  0.311
1989 De Arruda MV, Colli W, Zingales B. Terminal beta-D-galactofuranosyl epitopes recognized by antibodies that inhibit Trypanosoma cruzi internalization into mammalian cells. European Journal of Biochemistry / Febs. 182: 413-21. PMID 2472273 DOI: 10.1111/J.1432-1033.1989.Tb14847.X  0.317
1988 Zingales B, Arruda MV, Colli W. Carbohydrate epitopes (Galf----Manp) recognized by antibodies that inhibit trypomastigote interiorization into mammalian cells. MemóRias Do Instituto Oswaldo Cruz. 83: 240-2. PMID 2473379 DOI: 10.1590/S0074-02761988000500002  0.303
1987 Couto AS, Katzin AM, Colli W, de Lederkremer RM. Sialic acid in a complex oligosaccharide chain of the Tc-85 surface glycoprotein from the trypomastigote stage of Trypanosoma cruzi. Molecular and Biochemical Parasitology. 26: 145-53. PMID 3323904 DOI: 10.1016/0166-6851(87)90138-1  0.356
1987 Zingales B, Carniol C, de Lederkremer RM, Colli W. Direct sialic acid transfer from a protein donor to glycolipids of trypomastigote forms of Trypanosoma cruzi. Molecular and Biochemical Parasitology. 26: 135-44. PMID 2448618 DOI: 10.1016/0166-6851(87)90137-X  0.324
1986 Alves MJ, Abuin G, Kuwajima VY, Colli W. Partial inhibition of trypomastigote entry into cultured mammalian cells by monoclonal antibodies against a surface glycoprotein of Trypanosoma cruzi. Molecular and Biochemical Parasitology. 21: 75-82. PMID 3534565 DOI: 10.1016/0166-6851(86)90081-2  0.343
1985 Andrews NW, Alves MJ, Schumacher RI, Colli W. Trypanosoma cruzi: protection in mice immunized with 8-methoxypsoralen-inactivated trypomastigotes. Experimental Parasitology. 60: 255-62. PMID 3935472 DOI: 10.1016/0014-4894(85)90029-3  0.318
1985 Zingales B, Katzin AM, Arruda MV, Colli W. Correlation of tunicamycin-sensitive surface glycoproteins from Trypanosoma cruzi with parasite interiorization into mammalian cells. Molecular and Biochemical Parasitology. 16: 21-34. PMID 3929084 DOI: 10.1016/0166-6851(85)90046-5  0.403
1985 Couto AS, Zingales B, de Lederkremer RM, Colli W. Trypanosoma cruzi: metabolic labeling of trypomastigote sialoglycolipids. Experientia. 41: 736-8. PMID 3891398 DOI: 10.1007/Bf02012572  0.34
1985 Goldenberg S, Salles JM, Contreras VT, Lima Franco MP, Katzin AM, Colli W, Morel CM. Characterization of messenger RNA from epimastigotes and metacyclic trypomastigotes of Trypanosoma cruzi. Febs Letters. 180: 265-70. PMID 2857136 DOI: 10.1016/0014-5793(85)81083-8  0.347
1984 Andrews NW, Katzin AM, Colli W. Mapping of surface glycoproteins of Trypanosoma cruzi by two-dimensional electrophoresis. A correlation with the cell invasion capacity. European Journal of Biochemistry / Febs. 140: 599-604. PMID 6373254 DOI: 10.1111/J.1432-1033.1984.Tb08144.X  0.372
1984 Colli W. Interiorization of Trypanosoma cruzi into mammalian host cells in the light the parasite membrane chemical composition MemóRias Do Instituto Oswaldo Cruz. 79: 45-50. DOI: 10.1590/S0074-02761984000500010  0.314
1983 Katzin AM, Colli W. Lectin receptors in Trypanosoma cruzi. An N-acetyl-D-glucosamine-containing surface glycoprotein specific for the trypomastigote stage. Biochimica Et Biophysica Acta. 727: 403-11. PMID 6340740 DOI: 10.1016/0005-2736(83)90425-X  0.376
1982 Andrews NW, Colli W. Adhesion and interiorization of Trypanosoma cruzi in mammalian cells. The Journal of Protozoology. 29: 264-9. PMID 7047731 DOI: 10.1111/J.1550-7408.1982.Tb04024.X  0.343
1982 Zingales B, Andrews NW, Kuwajima VY, Colli W. Cell surface antigens of Trypanosoma cruzi: possible correlation with the interiorization process in mammalian cells. Molecular and Biochemical Parasitology. 6: 111-24. PMID 6182464 DOI: 10.1016/0166-6851(82)90069-X  0.363
1979 Alves MJM, Da Silveira JF, De Paiva CHR, Tanaka CT, Colli W. Evidence for the plasma membrane localization of carbohydrate-containing macromolecules from epimastigote forms of Trypanosoma cruzi Febs Letters. 99: 81-85. PMID 374124 DOI: 10.1016/0014-5793(79)80254-9  0.317
1979 Zingales B, Carniol C, Abrahamsohn PA, Colli W. Purification of an adenylyl cyclase-containing plasma membrane fraction from trypanosoma cruzi Bba - Biomembranes. 550: 233-244. PMID 365245 DOI: 10.1016/0005-2736(79)90210-4  0.302
1979 Da Silveira JF, Abrahamsohn PA, Colli W. Plasma membrane vesicles isolated from epimastigote forms of trypanosoma cruzi Bba - Biomembranes. 550: 222-232. PMID 365244 DOI: 10.1016/0005-2736(79)90209-8  0.334
1974 Alves MJ, Colli W. Agglutination of Trypanosoma cruzi by concanavalin A Journal of Protozoology. 21: 575-578. PMID 4214499 DOI: 10.1111/J.1550-7408.1974.Tb03704.X  0.32
1969 Colli W, Pullman ME. Adenosine diphosphate as the primary phosphoryl acceptor in oxidative phosphorylation. The Journal of Biological Chemistry. 244: 135-41. PMID 4975222  0.569
1969 Colli W, Hinkle PC, Pullman ME. Characterization of the fatty acid elongation system in soluble extracts and membrane preparations of rat liver mitochondria. The Journal of Biological Chemistry. 244: 6432-43. PMID 4390968  0.598
1959 RAW I, COLLI W. Crystalline cytochrome b5. Nature. 184: 1798-9. PMID 13854466 DOI: 10.1038/1841798A0  0.513
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