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Eric M. Bennett, Ph.D. - Publications

Affiliations: 
2003 Cornell University, Ithaca, NY, United States 
Area:
structure and function of proteins using X-ray crystallography
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24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Tumey LN, Li F, Rago B, Han X, Loganzo F, Musto S, Graziani EI, Puthenveetil S, Casavant J, Marquette K, Clark T, Bikker J, Bennett EM, Barletta F, Piche-Nicholas N, et al. Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates. The Aaps Journal. PMID 28439809 DOI: 10.1208/S12248-017-0083-7  0.31
2012 Gopalsamy A, Bennett EM, Shi M, Zhang WG, Bard J, Yu K. Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 6636-41. PMID 23021994 DOI: 10.1016/J.Bmcl.2012.08.107  0.301
2009 Zask A, Kaplan J, Verheijen JC, Richard DJ, Curran K, Brooijmans N, Bennett EM, Toral-Barza L, Hollander I, Ayral-Kaloustian S, Yu K. Morpholine derivatives greatly enhance the selectivity of mammalian target of rapamycin (mTOR) inhibitors. Journal of Medicinal Chemistry. 52: 7942-5. PMID 19916508 DOI: 10.1021/Jm901415X  0.311
2009 Petrelli R, Sham YY, Chen L, Felczak K, Bennett E, Wilson D, Aldrich C, Yu JS, Cappellacci L, Franchetti P, Grifantini M, Mazzola F, Di Stefano M, Magni G, Pankiewicz KW. Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues. Bioorganic & Medicinal Chemistry. 17: 5656-64. PMID 19596199 DOI: 10.1016/J.Bmc.2009.06.013  0.394
2009 Zask A, Kaplan J, Curran K, Verheijen JC, Richard DJ, Brooijmans N, Bennett E, Lucas J, Toral‐Barza L, Hollander I, Gibbons JJ, Abraham RT, Ayral‐Kaloustian S, Mansour TS, Yu K. Abstract B145: Highly selective pyrazolopyrimidine mTOR inhibitors with profound in vivo antitumor activity Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-B145  0.347
2008 Labello NP, Bennett EM, Ferguson DM, Aldrich CC. Quantitative three dimensional structure linear interaction energy model of 5'-O-[N-(salicyl)sulfamoyl]adenosine and the aryl acid adenylating enzyme MbtA. Journal of Medicinal Chemistry. 51: 7154-60. PMID 18959400 DOI: 10.1021/Jm800668U  0.39
2008 Neres J, Labello NP, Somu RV, Boshoff HI, Wilson DJ, Vannada J, Chen L, Barry CE, Bennett EM, Aldrich CC. Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine. Journal of Medicinal Chemistry. 51: 5349-70. PMID 18690677 DOI: 10.1021/Jm800567V  0.361
2008 Chen L, Petrelli R, Felczak K, Olesiak M, Bennett EM, Magni G, Pankiewicz KW. Novel cofactor-type inhibitors of NAD-dependent enzymes. NAD-based therapeutics Collection of Czechoslovak Chemical Communications. 10: 71-79. DOI: 10.1135/Css200810071  0.396
2007 Qiao C, Gupte A, Boshoff HI, Wilson DJ, Bennett EM, Somu RV, Barry CE, Aldrich CC. 5'-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: an adenylation enzyme required for siderophore biosynthesis of the mycobactins. Journal of Medicinal Chemistry. 50: 6080-94. PMID 17967002 DOI: 10.1021/Jm070905O  0.428
2007 Chen L, Gao G, Felczak K, Bonnac L, Patterson SE, Wilson D, Bennett EM, Jayaram HN, Hedstrom L, Pankiewicz KW. Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues. Journal of Medicinal Chemistry. 50: 5743-51. PMID 17958343 DOI: 10.1021/Jm070568J  0.309
2007 Bonnac L, Gao GY, Chen L, Felczak K, Bennett EM, Xu H, Kim T, Liu N, Oh H, Tonge PJ, Pankiewicz KW. Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry Letters. 17: 4588-91. PMID 17560106 DOI: 10.1016/J.Bmcl.2007.05.084  0.328
2007 Qiao C, Wilson DJ, Bennett EM, Aldrich CC. A mechanism-based aryl carrier protein/thiolation domain affinity probe. Journal of the American Chemical Society. 129: 6350-1. PMID 17469819 DOI: 10.1021/Ja069201E  0.318
2007 Chen L, Gao G, Bonnac L, Wilson DJ, Bennett EM, Jayaram HN, Pankiewicz KW. Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor. Bioorganic & Medicinal Chemistry Letters. 17: 3152-5. PMID 17395461 DOI: 10.1016/J.Bmcl.2007.03.035  0.345
2007 Bonnac L, Chen L, Pathak R, Gao G, Ming Q, Bennett E, Felczak K, Kullberg M, Patterson SE, Mazzola F, Magni G, Pankiewicz KW. Probing binding requirements of NAD kinase with modified substrate (NAD) analogues. Bioorganic & Medicinal Chemistry Letters. 17: 1512-5. PMID 17258457 DOI: 10.1016/J.Bmcl.2007.01.012  0.373
2006 Somu RV, Wilson DJ, Bennett EM, Boshoff HI, Celia L, Beck BJ, Barry CE, Aldrich CC. Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain. Journal of Medicinal Chemistry. 49: 7623-35. PMID 17181146 DOI: 10.1021/Jm061068D  0.41
2006 Vannada J, Bennett EM, Wilson DJ, Boshoff HI, Barry CE, Aldrich CC. Design, synthesis, and biological evaluation of beta-ketosulfonamide adenylation inhibitors as potential antitubercular agents. Organic Letters. 8: 4707-10. PMID 17020283 DOI: 10.1021/Ol0617289  0.366
2006 Somu RV, Boshoff H, Qiao C, Bennett EM, Barry CE, Aldrich CC. Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis. Journal of Medicinal Chemistry. 49: 31-4. PMID 16392788 DOI: 10.1021/Jm051060O  0.353
2004 Anand R, Hoskins AA, Bennett EM, Sintchak MD, Stubbe J, Ealick SE. A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex. Biochemistry. 43: 10343-52. PMID 15301532 DOI: 10.1021/Bi0491292  0.663
2004 Bauer JA, Bennett EM, Begley TP, Ealick SE. Three-dimensional structure of YaaE from Bacillus subtilis, a glutaminase implicated in pyridoxal-5'-phosphate biosynthesis. The Journal of Biological Chemistry. 279: 2704-11. PMID 14585832 DOI: 10.1074/Jbc.M310311200  0.647
2003 Bennett EM, Anand R, Allan PW, Hassan AE, Hong JS, Levasseur DN, McPherson DT, Parker WB, Secrist JA, Sorscher EJ, Townes TM, Waud WR, Ealick SE. Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system. Chemistry & Biology. 10: 1173-81. PMID 14700625 DOI: 10.1016/J.Chembiol.2003.11.008  0.642
2003 Bennett EM, Li C, Allan PW, Parker WB, Ealick SE. Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase. The Journal of Biological Chemistry. 278: 47110-8. PMID 12937174 DOI: 10.1074/Jbc.M304622200  0.653
2003 Tolbert WD, Zhang Y, Cottet SE, Bennett EM, Ekstrom JL, Pegg AE, Ealick SE. Mechanism of human S-adenosylmethionine decarboxylase proenzyme processing as revealed by the structure of the S68A mutant. Biochemistry. 42: 2386-95. PMID 12600205 DOI: 10.1021/Bi0268854  0.56
2002 Bennett EM, Ekstrom JL, Pegg AE, Ealick SE. Monomeric S-adenosylmethionine decarboxylase from plants provides an alternative to putrescine stimulation. Biochemistry. 41: 14509-17. PMID 12463749 DOI: 10.1021/Bi026710U  0.602
2002 Cheng G, Bennett EM, Begley TP, Ealick SE. Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution. Structure (London, England : 1993). 10: 225-35. PMID 11839308 DOI: 10.1016/S0969-2126(02)00708-6  0.553
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