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Edward N. Pugh - Publications

University of Pennsylvania, Philadelphia, PA, United States 

179 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Fortenbach C, Peinado Allina G, Shores CM, Karlen SJ, Miller EB, Bishop H, Trimmer JS, Burns ME, Pugh EN. Loss of the K+ channel Kv2.1 greatly reduces outward dark current and causes ionic dysregulation and degeneration in rod photoreceptors. The Journal of General Physiology. 153. PMID 33502442 DOI: 10.1085/jgp.202012687  1
2020 Meleppat RK, Ronning KE, Karlen SJ, Kothandath KK, Burns ME, Pugh EN, Zawadzki RJ. In Situ Morphologic and Spectral Characterization of Retinal Pigment Epithelium Organelles in Mice Using Multicolor Confocal Fluorescence Imaging. Investigative Ophthalmology & Visual Science. 61: 1. PMID 33137194 DOI: 10.1167/iovs.61.13.1  1
2020 Zhang P, Shibata B, Peinado G, Zawadzki RJ, FitzGerald P, Pugh EN. Measurement of Diurnal Variation in Rod Outer Segment Length In Vivo in Mice With the OCT Optoretinogram. Investigative Ophthalmology & Visual Science. 61: 9. PMID 32176260 DOI: 10.1167/iovs.61.3.9  0.6
2019 Zhang P, Miller EB, Manna SK, Meleppat RK, Pugh EN, Zawadzki RJ. Temporal speckle-averaging of optical coherence tomography volumes for cellular resolution neuronal and vascular retinal imaging. Neurophotonics. 6: 041105. PMID 31528657 DOI: 10.1117/1.NPh.6.4.041105  0.6
2019 Miller EB, Zhang P, Ching K, Pugh EN, Burns ME. In vivo imaging reveals transient microglia recruitment and functional recovery of photoreceptor signaling after injury. Proceedings of the National Academy of Sciences of the United States of America. PMID 31350349 DOI: 10.1073/pnas.1903336116  1
2019 Meleppat RK, Zhang P, Ju MJ, Manna SK, Jian Y, Pugh EN, Zawadzki RJ. Directional optical coherence tomography reveals melanin concentration-dependent scattering properties of retinal pigment epithelium. Journal of Biomedical Optics. 24: 1-10. PMID 31254332 DOI: 10.1117/1.JBO.24.6.066011  0.6
2019 Zhang P, Manna SK, Miller EB, Jian Y, Meleppat RK, Sarunic MV, Pugh EN, Zawadzki RJ. Aperture phase modulation with adaptive optics: a novel approach for speckle reduction and structure extraction in optical coherence tomography. Biomedical Optics Express. 10: 552-570. PMID 30800499 DOI: 10.1364/BOE.10.000552  0.6
2019 Goswami M, Wang X, Zhang P, Xiao W, Karlen SJ, Li Y, Zawadzki RJ, Burns ME, Lam KS, Pugh EN. Novel window for cancer nanotheranostics: non-invasive ocular assessments of tumor growth and nanotherapeutic treatment efficacy . Biomedical Optics Express. 10: 151-166. PMID 30775090 DOI: 10.1364/BOE.10.000151  1
2018 Zhang P, Mocci J, Wahl DJ, Meleppat RK, Manna SK, Quintavalla M, Muradore R, Sarunic MV, Bonora S, Pugh EN, Zawadzki RJ. Effect of a contact lens for in vivo mouse retinal imaging: Effective focal length changes and monochromatic aberrations. Experimental Eye Research. PMID 29604280 DOI: 10.1016/j.exer.2018.03.027  0.6
2018 Ronning KE, Allina GP, Miller EB, Zawadzki RJ, Pugh EN, Hermann R, Burns ME. Loss of cone function without degeneration in a novel Gnat2 knock-out mouse. Experimental Eye Research. PMID 29518352 DOI: 10.1016/j.exer.2018.02.024  1
2017 Wang X, Miller EB, Goswami M, Zhang P, Ronning KE, Karlen SJ, Zawadzki RJ, Pugh EN, Burns ME. Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130. Journal of Neuroinflammation. 14: 121. PMID 28645275 DOI: 10.1186/s12974-017-0886-6  1
2017 Zhang P, Zawadzki RJ, Goswami M, Nguyen PT, Yarov-Yarovoy V, Burns ME, Pugh EN. In vivo optophysiology reveals that G-protein activation triggers osmotic swelling and increased light scattering of rod photoreceptors. Proceedings of the National Academy of Sciences of the United States of America. PMID 28320964 DOI: 10.1073/pnas.1620572114  1
2017 Peinado Allina G, Fortenbach C, Naarendorp F, Gross OP, Pugh EN, Burns ME. Bright flash response recovery of mammalian rods in vivo is rate limited by RGS9. The Journal of General Physiology. PMID 28302678 DOI: 10.1085/jgp.201611692  1
2016 Zhang P, Goswami M, Zawadzki RJ, Pugh EN. The Photosensitivity of Rhodopsin Bleaching and Light-Induced Increases of Fundus Reflectance in Mice Measured In Vivo With Scanning Laser Ophthalmoscopy. Investigative Ophthalmology & Visual Science. 57: 3650-3664. PMID 27403994 DOI: 10.1167/iovs.16-19393  1
2016 Burns ME, Levine ES, Miller EB, Zam A, Zhang P, Zawadzki RJ, Pugh EN. New Developments in Murine Imaging for Assessing Photoreceptor Degeneration In Vivo. Advances in Experimental Medicine and Biology. 854: 269-75. PMID 26427421 DOI: 10.1007/978-3-319-17121-0_36  1
2016 Goswami M, Zhang P, Pugh EN, Zawadzki RJ. Visualization of chorioretinal vasculature in mice in vivo using a combined OCT/SLO imaging system Progress in Biomedical Optics and Imaging - Proceedings of Spie. 9693. DOI: 10.1117/12.2213609  1
2015 Zhang P, Zam A, Jian Y, Wang X, Li Y, Lam KS, Burns ME, Sarunic MV, Pugh EN, Zawadzki RJ. In vivo wide-field multispectral scanning laser ophthalmoscopy-optical coherence tomography mouse retinal imager: longitudinal imaging of ganglion cells, microglia, and Müller glia, and mapping of the mouse retinal and choroidal vasculature. Journal of Biomedical Optics. 20: 126005. PMID 26677070 DOI: 10.1117/1.JBO.20.12.126005  1
2015 Zhang P, Goswami M, Zam A, Pugh EN, Zawadzki RJ. Effect of scanning beam size on the lateral resolution of mouse retinal imaging with SLO. Optics Letters. 40: 5830-3. PMID 26670523 DOI: 10.1364/OL.40.005830  1
2015 Pugh EN. Photoreceptor disc morphogenesis: The classical evagination model prevails. The Journal of Cell Biology. 211: 491-3. PMID 26527745 DOI: 10.1083/jcb.201510067  1
2015 Bonora S, Jian Y, Zhang P, Zam A, Pugh EN, Zawadzki RJ, Sarunic MV. Wavefront correction and high-resolution in vivo OCT imaging with an objective integrated multi-actuator adaptive lens. Optics Express. 23: 21931-41. PMID 26368169 DOI: 10.1364/OE.23.021931  1
2015 Zawadzki RJ, Zhang P, Zam A, Miller EB, Goswami M, Wang X, Jonnal RS, Lee SH, Kim DY, Flannery JG, Werner JS, Burns ME, Pugh EN. Adaptive-optics SLO imaging combined with widefield OCT and SLO enables precise 3D localization of fluorescent cells in the mouse retina. Biomedical Optics Express. 6: 2191-210. PMID 26114038 DOI: 10.1364/BOE.6.002191  1
2015 Gross OP, Pugh EN, Burns ME. cGMP in mouse rods: the spatiotemporal dynamics underlying single photon responses. Frontiers in Molecular Neuroscience. 8: 6. PMID 25788876 DOI: 10.3389/fnmol.2015.00006  1
2015 Zhang T, Enemchukwu NO, Jones A, Wang S, Dennis E, Watt CB, Pugh EN, Fu Y. Genetic deletion of S-opsin prevents rapid cone degeneration in a mouse model of Leber congenital amaurosis. Human Molecular Genetics. 24: 1755-63. PMID 25416279 DOI: 10.1093/hmg/ddu588  1
2015 Rizzotto L, Bonora S, Jian Y, Zhang P, Zam A, Pugh EN, Mammano F, Zawadzki RJ, Sarunic MV. Comparison of a novel adaptive lens with deformable mirrors and its application in high-resolution in-vivo OCT imaging Progress in Biomedical Optics and Imaging - Proceedings of Spie. 9335. DOI: 10.1117/12.2180145  1
2015 Zhang P, Zam A, Jian Y, Wang X, Burns ME, Sarunic MV, Pugh EN, Zawadzki RJ. Multispectral scanning laser ophthalmoscopy combined with optical coherence tomography for simultaneous in vivo mouse retinal imaging Progress in Biomedical Optics and Imaging - Proceedings of Spie. 9307. DOI: 10.1117/12.2080468  1
2015 Zam A, Zhang P, Jian Y, Sarunic MV, Bonora S, Pugh EN, Zawadzki RJ. Progress on developing wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice Progress in Biomedical Optics and Imaging - Proceedings of Spie. 9312. DOI: 10.1117/12.2077867  1
2014 Levine ES, Zam A, Zhang P, Pechko A, Wang X, FitzGerald P, Pugh EN, Zawadzki RJ, Burns ME. Rapid light-induced activation of retinal microglia in mice lacking Arrestin-1. Vision Research. 102: 71-9. PMID 25091460 DOI: 10.1016/j.visres.2014.07.011  1
2014 Kessler C, Tillman M, Burns ME, Pugh EN. Rhodopsin in the rod surface membrane regenerates more rapidly than bulk rhodopsin in the disc membranes in vivo. The Journal of Physiology. 592: 2785-97. PMID 24801306 DOI: 10.1113/jphysiol.2014.272518  1
2014 Zhang P, Zam A, Pugh EN, Zawadzki RJ. Evaluation of state-of-the-art imaging systems for in vivo monitoring of retinal structure in mice: Current capabilities and limitations Progress in Biomedical Optics and Imaging - Proceedings of Spie. 8930. DOI: 10.1117/12.2040964  1
2013 Haeri M, Calvert PD, Solessio E, Pugh EN, Knox BE. Regulation of rhodopsin-eGFP distribution in transgenic xenopus rod outer segments by light. Plos One. 8: e80059. PMID 24260336 DOI: 10.1371/journal.pone.0080059  1
2013 Pugh EN, Gordon SE. Embracing the principles of the San Francisco Declaration of Research Assessment: Robert Balaban's editorial. The Journal of General Physiology. 142: 175. PMID 23980189 DOI: 10.1085/jgp.201311077  1
2013 Zawadzki R, Pugh EN. Spotlight summary: quantitative fundus autofluorescence and A2E increase with aging in wild-type and "Stargardt" mice. Investigative Ophthalmology & Visual Science. 54: 2991. PMID 23612484 DOI: 10.1167/iovs.13-12252  1
2013 Nikonov SS, Lyubarsky A, Fina ME, Nikonova ES, Sengupta A, Chinniah C, Ding XQ, Smith RG, Pugh EN, Vardi N, Dhingra A. Cones respond to light in the absence of transducin β subunit. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 5182-94. PMID 23516284 DOI: 10.1523/JNEUROSCI.5204-12.2013  1
2013 Morgan JI, Pugh EN. Scanning laser ophthalmoscope measurement of local fundus reflectance and autofluorescence changes arising from rhodopsin bleaching and regeneration. Investigative Ophthalmology & Visual Science. 54: 2048-59. PMID 23412087 DOI: 10.1167/iovs.12-11089  1
2013 Bonora S, Jian Y, Pugh EN, Sarunic MV, Zawadzki RJ. AO-OCT for in vivo mouse retinal imaging: Application of adaptive lens in wavefornt sensorless aberration correction Progress in Biomedical Optics and Imaging - Proceedings of Spie. 8934. DOI: 10.1117/12.2042018  1
2012 Pugh EN. Introducing the viewpoint. The Journal of General Physiology. 140: 579. PMID 23183691 DOI: 10.1085/jgp.201210924  1
2012 Gross OP, Pugh EN, Burns ME. Calcium feedback to cGMP synthesis strongly attenuates single-photon responses driven by long rhodopsin lifetimes. Neuron. 76: 370-82. PMID 23083739 DOI: 10.1016/j.neuron.2013.05.032  1
2012 Gross OP, Pugh EN, Burns ME. Spatiotemporal cGMP dynamics in living mouse rods. Biophysical Journal. 102: 1775-84. PMID 22768933 DOI: 10.1016/j.bpj.2012.03.035  1
2012 Insinna C, Daniele LL, Davis JA, Larsen DD, Kuemmel C, Wang J, Nikonov SS, Knox BE, Pugh EN. An S-opsin knock-in mouse (F81Y) reveals a role for the native ligand 11-cis-retinal in cone opsin biosynthesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8094-104. PMID 22674284 DOI: 10.1523/JNEUROSCI.0131-12.2012  1
2012 Sheu SS, Dirksen RT, Pugh EN. Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondria take center stage. The Journal of General Physiology. 139: 391-3. PMID 22641633 DOI: 10.1085/jgp.201210819  1
2012 Pugh EN. Introducing Elizabeth M. Adler, JGP executive editor Journal of General Physiology. 140: 1. DOI: 10.1085/jgp.201210843  1
2011 Sheu SS, Dirksen RT, Pugh EN. The 65th Symposium of the Society for General Physiologists: energizing research in mitochondrial physiology and medicine. The Journal of General Physiology. 138: 563-7. PMID 22124113 DOI: 10.1085/jgp.201110739  1
2011 Pugh EN. Redefining our menu: communications and reviews. The Journal of General Physiology. 138: 131. PMID 21788608 DOI: 10.1085/jgp.201110688  1
2011 Ellis-Davies GC, Pugh EN. The 64th Symposium of the Society for General Physiologists: optogenetics and superresolution microscopy take center stage. The Journal of General Physiology. 138: 1-11. PMID 21708951 DOI: 10.1085/jgp.201110673  1
2011 Pugh EN. Good scientists do reach and hold divergent views on important issues. The Journal of General Physiology. 137: 253. PMID 21357731 DOI: 10.1085/jgp.201110613  1
2011 Daniele LL, Insinna C, Chance R, Wang J, Nikonov SS, Pugh EN. A mouse M-opsin monochromat: retinal cone photoreceptors have increased M-opsin expression when S-opsin is knocked out. Vision Research. 51: 447-58. PMID 21219924 DOI: 10.1016/j.visres.2010.12.017  1
2011 Pugh EN. Associate editor: Sharona gordon Journal of General Physiology. 138: 473. DOI: 10.1085/jgp.201110729  1
2011 Pugh EN. Announcing the JGP journal club, a publication for early-career physiologists Journal of General Physiology. 137: 335-336. DOI: 10.1085/jgp.201110624  1
2011 Pugh EN. The job of associate editor Journal of General Physiology. 137: 1. DOI: 10.1085/jgp.201010583  1
2010 Pugh EN. We were there... The Journal of General Physiology. 136: 495. PMID 20974770 DOI: 10.1085/jgp.201010553  1
2010 Naarendorp F, Esdaille TM, Banden SM, Andrews-Labenski J, Gross OP, Pugh EN. Dark light, rod saturation, and the absolute and incremental sensitivity of mouse cone vision. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 12495-507. PMID 20844144 DOI: 10.1523/JNEUROSCI.2186-10.2010  1
2010 Dirksen RT, Pugh EN. Emerging questions about the macromolecular machines of muscle. The Journal of General Physiology. 136: 3-5. PMID 20584886 DOI: 10.1085/jgp.201010481  1
2010 Burns ME, Pugh EN. Lessons from photoreceptors: turning off g-protein signaling in living cells. Physiology (Bethesda, Md.). 25: 72-84. PMID 20430952 DOI: 10.1152/physiol.00001.2010  1
2010 Ng L, Lyubarsky A, Nikonov SS, Ma M, Srinivas M, Kefas B, St Germain DL, Hernandez A, Pugh EN, Forrest D. Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3347-57. PMID 20203194 DOI: 10.1523/JNEUROSCI.5267-09.2010  1
2010 Calvert PD, Schiesser WE, Pugh EN. Diffusion of a soluble protein, photoactivatable GFP, through a sensory cilium. The Journal of General Physiology. 135: 173-96. PMID 20176852 DOI: 10.1085/jgp.200910322  1
2010 Pugh EN. Editorial: Changes at the JGP Journal of General Physiology. 135: 545. DOI: 10.1085/jgp.201010465  1
2010 Pugh EN. New perspective: History of the Perspectives series Journal of General Physiology. 135: 1. DOI: 10.1085/jgp.200910378  1
2009 Pugh EN. Enlisting young physiologists. The Journal of General Physiology. 134: 451-2. PMID 19948996 DOI: 10.1085/jgp.200910364  1
2009 Burns ME, Pugh EN. RGS9 concentration matters in rod phototransduction. Biophysical Journal. 97: 1538-47. PMID 19751658 DOI: 10.1016/j.bpj.2009.06.037  1
2009 Parry DA, Toomes C, Bida L, Danciger M, Towns KV, McKibbin M, Jacobson SG, Logan CV, Ali M, Bond J, Chance R, Swendeman S, Daniele LL, Springell K, Adams M, ... ... Pugh EN, et al. Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice. American Journal of Human Genetics. 84: 683-91. PMID 19409519 DOI: 10.1016/j.ajhg.2009.04.005  1
2009 Pugh EN. Kudos to reviewers for the JGP: you make our science better. The Journal of General Physiology. 133: 129-30. PMID 19171768 DOI: 10.1085/jgp.200910193  1
2009 Pugh EN. Journal of General Physiology: Editorial Journal of General Physiology. 133: 461-462. DOI: 10.1085/jgp.200910242  1
2008 Nikonov SS, Brown BM, Davis JA, Zuniga FI, Bragin A, Pugh EN, Craft CM. Mouse cones require an arrestin for normal inactivation of phototransduction. Neuron. 59: 462-74. PMID 18701071 DOI: 10.1016/j.neuron.2008.06.011  1
2008 Daniele LL, Sauer B, Gallagher SM, Pugh EN, Philp NJ. Altered visual function in monocarboxylate transporter 3 (Slc16a8) knockout mice. American Journal of Physiology. Cell Physiology. 295: C451-7. PMID 18524945 DOI: 10.1152/ajpcell.00124.2008  1
2008 Pugh EN, Andersen OS. Models and mechanistic insight. The Journal of General Physiology. 131: 515-9. PMID 18504312 DOI: 10.1085/jgp.200810041  1
2008 Maguire AM, Simonelli F, Pierce EA, Pugh EN, Mingozzi F, Bennicelli J, Banfi S, Marshall KA, Testa F, Surace EM, Rossi S, Lyubarsky A, Arruda VR, Konkle B, Stone E, et al. Safety and efficacy of gene transfer for Leber's congenital amaurosis. The New England Journal of Medicine. 358: 2240-8. PMID 18441370 DOI: 10.1056/NEJMoa0802315  1
2008 Feathers KL, Lyubarsky AL, Khan NW, Teofilo K, Swaroop A, Williams DS, Pugh EN, Thompson DA. Nrl-knockout mice deficient in Rpe65 fail to synthesize 11-cis retinal and cone outer segments. Investigative Ophthalmology & Visual Science. 49: 1126-35. PMID 18326740 DOI: 10.1167/iovs.07-1234  1
2008 Pugh EN. The legacy of Olaf Sparre Andersen and future directions of the Journal of General Physiology Journal of General Physiology. 132: 1-3. DOI: 10.1085/jgp.200810063  1
2007 Lamb TD, Collin SP, Pugh EN. Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews. Neuroscience. 8: 960-76. PMID 18026166 DOI: 10.1038/nrn2283  1
2007 Daniele LL, Adams RH, Durante DE, Pugh EN, Philp NJ. Novel distribution of junctional adhesion molecule-C in the neural retina and retinal pigment epithelium. The Journal of Comparative Neurology. 505: 166-76. PMID 17853450 DOI: 10.1002/cne.21489  1
2007 Liu Q, Tan G, Levenkova N, Li T, Pugh EN, Rux JJ, Speicher DW, Pierce EA. The proteome of the mouse photoreceptor sensory cilium complex. Molecular & Cellular Proteomics : McP. 6: 1299-317. PMID 17494944 DOI: 10.1074/mcp.M700054-MCP200  1
2007 Calvert PD, Peet JA, Bragin A, Schiesser WE, Pugh EN. Fluorescence relaxation in 3D from diffraction-limited sources of PAGFP or sinks of EGFP created by multiphoton photoconversion. Journal of Microscopy. 225: 49-71. PMID 17286695 DOI: 10.1111/j.1365-2818.2007.01715.x  1
2007 Lin SS, Pugh EN, Engheta N. Polarization imaging in shadow and glare Optics Infobase Conference Papers 1
2006 Lin SS, Yemelyanov KM, Pugh EN, Engheta N. Separation and contrast enhancement of overlapping cast shadow components using polarization. Optics Express. 14: 7099-108. PMID 19529081 DOI: 10.1364/OE.14.007099  1
2006 Lamb TD, Pugh EN. Phototransduction, dark adaptation, and rhodopsin regeneration the proctor lecture. Investigative Ophthalmology & Visual Science. 47: 5137-52. PMID 17122096 DOI: 10.1167/iovs.06-0849  1
2006 Calvert PD, Strissel KJ, Schiesser WE, Pugh EN, Arshavsky VY. Light-driven translocation of signaling proteins in vertebrate photoreceptors. Trends in Cell Biology. 16: 560-8. PMID 16996267 DOI: 10.1016/j.tcb.2006.09.001  1
2006 Lin SS, Yemelyanov KM, Pugh EN, Engheta N. Polarization-based and specular-reflection-based noncontact latent fingerprint imaging and lifting. Journal of the Optical Society of America. a, Optics, Image Science, and Vision. 23: 2137-53. PMID 16912740 DOI: 10.1364/JOSAA.23.002137  1
2006 Pugh EN. RGS expression level precisely regulates the duration of rod photoresponses. Neuron. 51: 391-3. PMID 16908403 DOI: 10.1016/j.neuron.2006.08.002  1
2006 Yemelyanov KM, Lin SS, Pugh EN, Engheta N. Adaptive algorithms for two-channel polarization sensing under various polarization statistics with nonuniform distributions. Applied Optics. 45: 5504-20. PMID 16855649 DOI: 10.1364/AO.45.005504  1
2006 Nikonov SS, Kholodenko R, Lem J, Pugh EN. Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings. The Journal of General Physiology. 127: 359-74. PMID 16567464 DOI: 10.1085/jgp.200609490  1
2006 Lin SS, Yemelyanov KM, Pugh EN, Engheta N. Shadow vision enhancement using polarization imaging Optics Infobase Conference Papers 1
2005 Rex TS, Peet JA, Surace EM, Calvert PD, Nikonov SS, Lyubarsky AL, Bendo E, Hughes T, Pugh EN, Bennett J. The distribution, concentration, and toxicity of enhanced green fluorescent protein in retinal cells after genomic or somatic (virus-mediated) gene transfer. Molecular Vision. 11: 1236-45. PMID 16402024  1
2005 Pugh EN, Baehr W, Zrenner E. Neuroimaging the retina. Vision Research. 45: 3431. PMID 16289207 DOI: 10.1016/j.visres.2005.09.040  1
2005 Lyubarsky AL, Savchenko AB, Morocco SB, Daniele LL, Redmond TM, Pugh EN. Mole quantity of RPE65 and its productivity in the generation of 11-cis-retinal from retinyl esters in the living mouse eye. Biochemistry. 44: 9880-8. PMID 16026160 DOI: 10.1021/bi0505363  1
2005 Wenzel A, Oberhauser V, Pugh EN, Lamb TD, Grimm C, Samardzija M, Fahl E, Seeliger MW, Remé CE, von Lintig J. The retinal G protein-coupled receptor (RGR) enhances isomerohydrolase activity independent of light. The Journal of Biological Chemistry. 280: 29874-84. PMID 15961402 DOI: 10.1074/jbc.M503603200  1
2005 Daniele LL, Lillo C, Lyubarsky AL, Nikonov SS, Philp N, Mears AJ, Swaroop A, Williams DS, Pugh EN. Cone-like morphological, molecular, and electrophysiological features of the photoreceptors of the Nrl knockout mouse. Investigative Ophthalmology & Visual Science. 46: 2156-67. PMID 15914637 DOI: 10.1167/iovs.04-1427  1
2005 Nikonov SS, Daniele LL, Zhu X, Craft CM, Swaroop A, Pugh EN. Photoreceptors of Nrl -/- mice coexpress functional S- and M-cone opsins having distinct inactivation mechanisms. The Journal of General Physiology. 125: 287-304. PMID 15738050 DOI: 10.1085/jgp.200409208  1
2005 Calvert P, Peet JA, Bragin A, Pugh EN, Schiesser WE. Fluorescence relaxation in 3d from a diffraction-limited sink of Egfp or source of Pagfp in live Cho cells Aiche Annual Meeting, Conference Proceedings. 8431-8432.  1
2005 Yemelyanov KM, Lin SS, Pugh EN, Engheta N. Polarization-based segmentation for enhancement of target detection in adaptive polarization-difference imaging Optics Infobase Conference Papers 1
2005 Lin SS, Yemelyanov KM, Pugh EN, Engheta N. Optical non-invasive latent fingerprint lifting Optics Infobase Conference Papers 1
2004 Lyubarsky AL, Daniele LL, Pugh EN. From candelas to photoisomerizations in the mouse eye by rhodopsin bleaching in situ and the light-rearing dependence of the major components of the mouse ERG. Vision Research. 44: 3235-51. PMID 15535992 DOI: 10.1016/j.visres.2004.09.019  1
2004 Hahn P, Lindsten T, Lyubarsky A, Ying GS, Pugh EN, Thompson CB, Dunaief JL. Deficiency of Bax and Bak protects photoreceptors from light damage in vivo. Cell Death and Differentiation. 11: 1192-7. PMID 15272317 DOI: 10.1038/sj.cdd.4401486  1
2004 Peet JA, Bragin A, Calvert PD, Nikonov SS, Mani S, Zhao X, Besharse JC, Pierce EA, Knox BE, Pugh EN. Quantification of the cytoplasmic spaces of living cells with EGFP reveals arrestin-EGFP to be in disequilibrium in dark adapted rod photoreceptors. Journal of Cell Science. 117: 3049-59. PMID 15197244 DOI: 10.1242/jcs.01167  1
2004 Lamb TD, Pugh EN. Dark adaptation and the retinoid cycle of vision. Progress in Retinal and Eye Research. 23: 307-80. PMID 15177205 DOI: 10.1016/j.preteyeres.2004.03.001  1
2004 Dejneka NS, Surace EM, Aleman TS, Cideciyan AV, Lyubarsky A, Savchenko A, Redmond TM, Tang W, Wei Z, Rex TS, Glover E, Maguire AM, Pugh EN, Jacobson SG, Bennett J. In utero gene therapy rescues vision in a murine model of congenital blindness. Molecular Therapy : the Journal of the American Society of Gene Therapy. 9: 182-8. PMID 14759802 DOI: 10.1016/j.ymthe.2003.11.013  1
2004 Lin SS, Yemelyanov KM, Pugh EN, Engheta N. Polarization enhanced visual surveillance techniques Conference Proceeding - Ieee International Conference On Networking, Sensing and Control. 1: 216-221.  1
2003 Liu Q, Lyubarsky A, Skalet JH, Pugh EN, Pierce EA. RP1 is required for the correct stacking of outer segment discs. Investigative Ophthalmology & Visual Science. 44: 4171-83. PMID 14507858 DOI: 10.1167/iovs.03-0410  1
2003 Surace EM, Auricchio A, Reich SJ, Rex T, Glover E, Pineles S, Tang W, O'Connor E, Lyubarsky A, Savchenko A, Pugh EN, Maguire AM, Wilson JM, Bennett J. Delivery of adeno-associated virus vectors to the fetal retina: impact of viral capsid proteins on retinal neuronal progenitor transduction. Journal of Virology. 77: 7957-63. PMID 12829835 DOI: 10.1128/JVI.77.14.7957-7963.2003  1
2003 Yemelyanov KM, Lin SS, Luis WQ, Pugh EN, Engheta N. Bio-inspired display of polarization information using selected visual cues Proceedings of Spie - the International Society For Optical Engineering. 5158: 71-84.  1
2003 Yemelyanov KM, Lo MA, Pugh EN, Engheta N. Display of polarization information by coherently moving dots Optics Express. 11: 1577-1584.  1
2002 Demb JB, Pugh EN. Connexin36 forms synapses essential for night vision. Neuron. 36: 551-3. PMID 12441044 DOI: 10.1016/S0896-6273(02)01062-0  1
2002 Sokolov M, Lyubarsky AL, Strissel KJ, Savchenko AB, Govardovskii VI, Pugh EN, Arshavsky VY. Massive light-driven translocation of transducin between the two major compartments of rod cells: a novel mechanism of light adaptation. Neuron. 34: 95-106. PMID 11931744 DOI: 10.1016/S0896-6273(02)00636-0  1
2002 Lyubarsky AL, Lem J, Chen J, Falsini B, Iannaccone A, Pugh EN. Functionally rodless mice: transgenic models for the investigation of cone function in retinal disease and therapy. Vision Research. 42: 401-15. PMID 11853756 DOI: 10.1016/S0042-6989(01)00214-0  1
2002 Arshavsky VY, Lamb TD, Pugh EN. G proteins and phototransduction. Annual Review of Physiology. 64: 153-87. PMID 11826267 DOI: 10.1146/annurev.physiol.64.082701.102229  1
2001 Rattner A, Smallwood PM, Williams J, Cooke C, Savchenko A, Lyubarsky A, Pugh EN, Nathans J. A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival. Neuron. 32: 775-86. PMID 11738025 DOI: 10.1016/S0896-6273(01)00531-1  1
2001 Pugh EN. Rods are rods and cones cones, and (never) the twain shall meet. Neuron. 32: 375-6. PMID 11709146 DOI: 10.1016/S0896-6273(01)00492-5  1
2001 Lyubarsky AL, Naarendorp F, Zhang X, Wensel T, Simon MI, Pugh EN. RGS9-1 is required for normal inactivation of mouse cone phototransduction. Molecular Vision. 7: 71-8. PMID 11262419  1
2000 Dhingra A, Lyubarsky A, Jiang M, Pugh EN, Birnbaumer L, Sterling P, Vardi N. The light response of ON bipolar neurons requires G[alpha]o. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 9053-8. PMID 11124982  1
2000 Nikonov S, Lamb TD, Pugh EN. The role of steady phosphodiesterase activity in the kinetics and sensitivity of the light-adapted salamander rod photoresponse. The Journal of General Physiology. 116: 795-824. PMID 11099349 DOI: 10.1085/jgp.116.6.795  1
2000 Calvert PD, Krasnoperova NV, Lyubarsky AL, Isayama T, Nicoló M, Kosaras B, Wong G, Gannon KS, Margolskee RF, Sidman RL, Pugh EN, Makino CL, Lem J. Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit. Proceedings of the National Academy of Sciences of the United States of America. 97: 13913-8. PMID 11095744 DOI: 10.1073/pnas.250478897  1
2000 Leskov IB, Klenchin VA, Handy JW, Whitlock GG, Govardovskii VI, Bownds MD, Lamb TD, Pugh EN, Arshavsky VY. The gain of rod phototransduction: reconciliation of biochemical and electrophysiological measurements. Neuron. 27: 525-37. PMID 11055435 DOI: 10.1016/S0896-6273(00)00063-5  1
2000 Lyubarsky AL, Chen C, Simon MI, Pugh EN. Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 2209-17. PMID 10704496  1
2000 Pugh EN, Lamb TD. Chapter 5 Phototransduction in vertebrate rods and cones: Molecular mechanisms of amplification, recovery and light adaptation Handbook of Biological Physics. 3: 183-255. DOI: 10.1016/S1383-8121(00)80008-1  1
2000 Stavenga DG, DeGrip WJ, Pugh EN. Preface to volume 3 molecular mechanisms in visual transduction Handbook of Biological Physics. 3: vii-ix. DOI: 10.1016/S1383-8121(00)80002-0  1
1999 Pugh EN, Nikonov S, Lamb TD. Molecular mechanisms of vertebrate photoreceptor light adaptation. Current Opinion in Neurobiology. 9: 410-8. PMID 10448166 DOI: 10.1016/S0959-4388(99)80062-2  1
1999 Pugh EN. Variability in single photon responses: a cut in the Gordian knot of rod phototransduction? Neuron. 23: 205-8. PMID 10399927 DOI: 10.1016/S0896-6273(00)80772-2  1
1999 Lyubarsky AL, Falsini B, Pennesi ME, Valentini P, Pugh EN. UV- and midwave-sensitive cone-driven retinal responses of the mouse: a possible phenotype for coexpression of cone photopigments. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 442-55. PMID 9870972  1
1998 Pennesi ME, Lyubarsky AL, Pugh EN. Extreme responsiveness of the pupil of the dark-adapted mouse to steady retinal illumination. Investigative Ophthalmology & Visual Science. 39: 2148-56. PMID 9761294  1
1998 Arshavsky VY, Pugh EN. Lifetime regulation of G protein-effector complex: emerging importance of RGS proteins. Neuron. 20: 11-4. PMID 9459437 DOI: 10.1016/S0896-6273(00)80430-4  1
1998 Nikonov S, Engheta N, Pugh EN. Kinetics of recovery of the dark-adapted salamander rod photoresponse. The Journal of General Physiology. 111: 7-37. PMID 9417132 DOI: 10.1085/jgp.111.1.7  1
1998 Tyo JS, Pugh EN, Engheta N. Colorimetric representations for use with polarization-difference imaging of objects in scattering media Journal of the Optical Society of America a: Optics and Image Science, and Vision. 15: 367-374.  1
1997 Pugh EN, Duda T, Sitaramayya A, Sharma RK. Photoreceptor guanylate cyclases: a review. Bioscience Reports. 17: 429-73. PMID 9419388 DOI: 10.1023/A:1027365520442  1
1997 Cideciyan AV, Pugh EN, Lamb TD, Huang Y, Jacobson SG. Rod plateaux during dark adaptation in Sorsby's fundus dystrophy and vitamin A deficiency. Investigative Ophthalmology & Visual Science. 38: 1786-94. PMID 9286267  1
1997 Gold GH, Pugh EN. Olfactory adaptation. The nose leads the eye. Nature. 385: 677, 679. PMID 9034182 DOI: 10.1038/385677a0  1
1997 Zhang LL, Nikonov SS, Bronk PM, Pugh EN. Recovery components of fish cone photoresponses Investigative Ophthalmology and Visual Science. 38: S614.  1
1996 Tyo JS, Rowe MP, Pugh EN, Engheta N. Target detection in optically scattering media by polarization-difference imaging. Applied Optics. 35: 1855-70. PMID 21085310  1
1996 Breslin PA, Beauchamp GK, Pugh EN. Monogeusia for fructose, glucose, sucrose, and maltose. Perception & Psychophysics. 58: 327-41. PMID 8935894 DOI: 10.3758/BF03206809  1
1996 Pugh EN. Cooperativity in cyclic nucleotide-gated ion channels. The Journal of General Physiology. 107: 165-7. PMID 8833338  1
1996 Lyubarsky A, Nikonov S, Pugh EN. The kinetics of inactivation of the rod phototransduction cascade with constant Ca2+i. The Journal of General Physiology. 107: 19-34. PMID 8741728  1
1996 Lyubarsky AL, Pugh EN. Recovery phase of the murine rod photoresponse reconstructed from electroretinographic recordings. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 563-71. PMID 8551340  1
1996 Reiser MA, Williams TP, Pugh EN. The effect of light history on the aspartate-isolated fast-PIII responses of the albino rat retina. Investigative Ophthalmology & Visual Science. 37: 221-9. PMID 8550327  1
1996 Jiang H, Lyubarsky A, Vardi N, Pugh EN, Chen J, Xu J, Simon MI, Wu D. Phospholipase β4-knockout mouse exhibits retinal phenotype Investigative Ophthalmology and Visual Science. 37: S809.  1
1996 Lyubarsky AL, Pugh EN. "Long tails" of mouse rod photoresponse recovery to rod-saturating conditioning flashes revealed in B-wave Investigative Ophthalmology and Visual Science. 37: S136.  1
1996 Nikonov SS, Lyubarsky AL, Pugh EN. Hydroxylamine decreases rod sensitivity in situ without changing the dominant time constant of recovery Investigative Ophthalmology and Visual Science. 37: S5.  1
1996 Rowe MP, Corless JM, Engheta N, Pugh EN. Scanning interferometry of sunfish cones. I. Longitudinal variation in single-cone refractive index Journal of the Optical Society of America a: Optics and Image Science, and Vision. 13: 2141-2150.  1
1995 Rowe MP, Pugh EN, Tyo JS, Engheta N. Polarization-difference imaging: a biologically inspired technique for observation through scattering media. Optics Letters. 20: 608-10. PMID 19859271 DOI: 10.1364/OL.20.000608  1
1994 Breton ME, Schueller AW, Lamb TD, Pugh EN. Analysis of ERG a-wave amplification and kinetics in terms of the G-protein cascade of phototransduction. Investigative Ophthalmology & Visual Science. 35: 295-309. PMID 8300357  1
1994 Rowe MP, Engheta N, Easter SS, Pugh EN. Graded-index model of a fish double cone exhibits differential polarization sensitivity. Journal of the Optical Society of America. a, Optics, Image Science, and Vision. 11: 55-70. PMID 8106915 DOI: 10.1364/JOSAA.11.000055  1
1994 Dumke CL, Arshavsky VY, Calvert PD, Bownds MD, Pugh EN. Rod outer segment structure influences the apparent kinetic parameters of cyclic GMP phosphodiesterase. The Journal of General Physiology. 103: 1071-98. PMID 7931138 DOI: 10.1085/jgp.103.6.1071  1
1993 Pugh EN, Lamb TD. Amplification and kinetics of the activation steps in phototransduction. Biochimica Et Biophysica Acta. 1141: 111-49. PMID 8382952 DOI: 10.1016/0005-2728(93)90038-H  1
1993 Pugh EN, Lisman J, Payne R. Strange case of the third eye. Nature. 364: 389-90. PMID 8332207 DOI: 10.1038/364389a0  1
1993 Olson A, Pugh EN. Diffusion coefficient of cyclic GMP in salamander rod outer segments estimated with two fluorescent probes. Biophysical Journal. 65: 1335-52. PMID 8241412 DOI: 10.1016/S0006-3495(93)81177-9  1
1992 Lamb TD, Pugh EN. G-protein cascades: gain and kinetics. Trends in Neurosciences. 15: 291-8. PMID 1384198 DOI: 10.1016/0166-2236(92)90079-N  1
1992 Lamb TD, Pugh EN. A quantitative account of the activation steps involved in phototransduction in amphibian photoreceptors. The Journal of Physiology. 449: 719-58. PMID 1326052  1
1992 Calkins DJ, Thornton JE, Pugh EN. Monochromatism determined at a long-wavelength/middle-wavelength cone-antagonistic locus. Vision Research. 32: 2349-67. PMID 1288011 DOI: 10.1016/0042-6989(92)90098-4  1
1991 Cameron DA, Pugh EN. Double cones as a basis for a new type of polarization vision in vertebrates. Nature. 353: 161-4. PMID 1891046 DOI: 10.1038/353161a0  1
1990 Pugh EN, Cobbs WH, Barkdoll AE. Calcium inhibition of ATP-dependent inactivation of rod disk phosphodiesterase in isolated rods and membrane suspensions. Neuroscience Research. Supplement : the Official Journal of the Japan Neuroscience Society. 12: S183-90. PMID 2243635 DOI: 10.1016/0921-8696(90)90020-4  1
1990 Cameron DA, Pugh EN. The magnitude, time course and spatial distribution of current induced in salamander rods by cyclic guanine nucleotides. The Journal of Physiology. 430: 419-39. PMID 1964967  1
1990 Pugh EN, Lamb TD. Cyclic GMP and calcium: the internal messengers of excitation and adaptation in vertebrate photoreceptors. Vision Research. 30: 1923-48. PMID 1962979 DOI: 10.1016/0042-6989(90)90013-B  1
1989 Barkdoll AE, Pugh EN, Sitaramayya A. Calcium dependence of the activation and inactivation kinetics of the light-activated phosphodiesterase of retinal rods. The Journal of General Physiology. 93: 1091-108. PMID 2549175  1
1988 Barkdoll AE, Pugh EN, Sitaramayya A. Kinetics of the hydrolysis of 8-bromo-cyclic GMP by the light-activated phosphodiesterase of toad rods. Journal of Neurochemistry. 50: 839-46. PMID 2828548  1
1987 Pugh EN, Miller WH. Special topic: phototransduction in vertebrates. General introduction. Annual Review of Physiology. 49: 711-4. PMID 3566215 DOI: 10.1146/  1
1987 Pugh EN. The nature and identity of the internal excitational transmitter of vertebrate phototransduction. Annual Review of Physiology. 49: 715-41. PMID 3032080 DOI: 10.1146/  1
1987 Cobbs WH, Pugh EN. Kinetics and components of the flash photocurrent of isolated retinal rods of the larval salamander, Ambystoma tigrinum. The Journal of Physiology. 394: 529-72. PMID 2832596  1
1986 Pugh EN, Kirk DB. The pi mechanisms of W S Stiles: an historical review. Perception. 15: 705-28. PMID 3309877  1
1986 Pugh EN, Cobbs WH. Visual transduction in vertebrate rods and cones: a tale of two transmitters, calcium and cyclic GMP. Vision Research. 26: 1613-43. PMID 2441524 DOI: 10.1016/0042-6989(86)90051-9  1
1985 Friedman LJ, Thornton JE, Pugh EN. Cone antagonism along visual pathways of red/green dichromats. Vision Research. 25: 1647-54. PMID 3879568 DOI: 10.1016/0042-6989(85)90136-1  1
1985 Cobbs WH, Barkdoll AE, Pugh EN. Cyclic GMP increases photocurrent and light sensitivity of retinal cones. Nature. 317: 64-6. PMID 2993915 DOI: 10.1038/317064a0  1
1985 Cobbs WH, Pugh EN. Cyclic GMP can increase rod outer-segment light-sensitive current 10-fold without delay of excitation. Nature. 313: 585-7. PMID 2982108 DOI: 10.1038/313585a0  1
1984 Liebman PA, Mueller P, Pugh EN. Protons suppress the dark current of frog retinal rods. The Journal of Physiology. 347: 85-110. PMID 6608584 DOI: 10.1113/jphysiol.1984.sp015055  1
1984 Friedman LJ, Yim MH, Pugh EN. Temporal integration of the pi 1/pi 3 pathway in normal and dichromatic vision. Vision Research. 24: 743-50. PMID 6331680 DOI: 10.1016/0042-6989(84)90215-3  1
1983 Thornton JE, Pugh EN. Red/Green color opponency at detection threshold. Science (New York, N.Y.). 219: 191-3. PMID 6849131  1
1983 Mueller P, Pugh EN. Protons block the dark current of isolated retinal rods. Proceedings of the National Academy of Sciences of the United States of America. 80: 1892-6. PMID 6300877  1
1982 Liebman PA, Pugh EN. Gain, speed and sensitivity of GTP binding vs PDE activation in visual excitation. Vision Research. 22: 1475-80. PMID 6305023 DOI: 10.1016/0042-6989(82)90212-7  1
1981 Liebman PA, Pugh EN. Chapter 9 Control of Rod Disk Membrane Phosphodiesterase and a Model for Visual Transduction Current Topics in Membranes and Transport. 15: 157-170. DOI: 10.1016/S0070-2161(08)60500-6  1
1980 Pugh EN, Larimer J. Test of the identity of the site of blue/yellow hue cancellation and the site of chromatic antagonism in the pi 1 pathway. Vision Research. 20: 779-88. PMID 7456339 DOI: 10.1016/0042-6989(80)90009-7  1
1980 Wandell BA, Pugh EN. Detection of long-duration, long-wavelength incremental flashes by a chromatically coded pathway. Vision Research. 20: 625-36. PMID 7434597 DOI: 10.1016/0042-6989(80)90119-4  1
1980 Wandell BA, Pugh EN. A field-additive pathway detects brief-duration, long-wavelength incremental flashes. Vision Research. 20: 613-24. PMID 7434596 DOI: 10.1016/0042-6989(80)90118-2  1
1980 Liebman PA, Pugh EN. ATP mediates rapid reversal of cyclic GMP phosphodiesterase activation in visual receptor membranes. Nature. 287: 734-6. PMID 6107856 DOI: 10.1038/287734a0  1
1979 Pugh EN, Mollon JD. A theory of the pi1 and pi3 color mechanisms of Stiles. Vision Research. 19: 293-312. PMID 444331 DOI: 10.1016/0042-6989(79)90175-5  1
1979 Liebman PA, Pugh EN. The control of phosphodiesterase in rod disk membranes: kinetics, possible mechanisms and significance for vision. Vision Research. 19: 375-80. PMID 224596 DOI: 10.1016/0042-6989(79)90097-X  1
1978 Pugh EN, Sigel C. Evaluation of the candidacy of the pi-mechanisms of Stiles for color-matching fundamentals. Vision Research. 18: 317-30. PMID 664305 DOI: 10.1016/0042-6989(78)90166-9  1
1977 Augenstein EJ, Pugh EN. The dynamics of the pi 1 colour mechanism: further evidence for two sites of adaptation. The Journal of Physiology. 272: 247-81. PMID 592192 DOI: 10.1113/jphysiol.1977.sp012043  1
1977 Alpern M, Pugh EN. Variation in the action spectrum of erythrolabe among deuteranopes. The Journal of Physiology. 266: 613-46. PMID 301186 DOI: 10.1113/jphysiol.1977.sp011785  1
1976 Alpern M, Bastian B, Pugh EN, Gras W. Altered ocular pigments, photostable and labile: two causes of deuteranomalous trichromacy. Modern Problems in Ophthalmology. 17: 273-91. PMID 1085880  1
1976 Pugh EN. The nature of the pi1 colour mechanism of W.S. Stiles. The Journal of Physiology. 257: 713-47. PMID 950611 DOI: 10.1113/jphysiol.1976.sp011394  1
1975 Pugh EN. Rushton's paradox: rod dark adaptation after flash photolysis. The Journal of Physiology. 248: 413-31. PMID 1151791 DOI: 10.1113/jphysiol.1975.sp010982  1
1975 Pugh EN. Rhodopsin flash photolysis in man. The Journal of Physiology. 248: 393-412. PMID 1151790 DOI: 10.1113/jphysiol.1975.sp010981  1
1974 Alpern M, Pugh EN. The density and photosensitivity of human rhodopsin in the living retina. The Journal of Physiology. 237: 341-70. PMID 4825455 DOI: 10.1113/jphysiol.1974.sp010485  1
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