| Year |
Citation |
Score |
| 2020 |
Nam HY, Choi J, Kumar SD, Nielsen JE, Kyeong M, Wang S, Kang D, Lee Y, Lee J, Yoon MH, Hong S, Lund R, Jenssen H, Shin SY, Seo J. Helicity modulation improves selectivity of antimicrobial peptoids. Acs Infectious Diseases. PMID 32865961 DOI: 10.1021/Acsinfecdis.0C00356 |
0.306 |
|
| 2020 |
Nam HY, Song D, Eo J, Choi NE, Hong JA, Hong KT, Lee JS, Seo J, Lee J. Activity-based probes for the high temperature requirement A serine proteases. Acs Chemical Biology. PMID 32786264 DOI: 10.1021/Acschembio.0C00279 |
0.338 |
|
| 2019 |
Kim S, Nam HY, Lee J, Seo J. Mitochondria-targeting peptides and peptidomimetics: recent progress and design principles. Biochemistry. PMID 31696703 DOI: 10.1021/Acs.Biochem.9B00857 |
0.37 |
|
| 2019 |
Hoang VH, Ngo VTH, Cui M, Manh NV, Tran PT, Ann J, Ha H, Kim H, Choi K, Kim YH, Chang H, Macalino SJY, Lee J, Choi S, Lee J. Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer's Agents by Structure-Based Design. Journal of Medicinal Chemistry. PMID 31411468 DOI: 10.1021/Acs.Jmedchem.9B00751 |
0.369 |
|
| 2019 |
Yoon S, Kim SE, Kim JH, Yoon I, Tran PT, Ann J, Kim C, Byun WS, Lee S, Kim S, Lee J, Lee J. Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1). Bioorganic & Medicinal Chemistry. PMID 30755350 DOI: 10.1016/J.Bmc.2019.01.037 |
0.434 |
|
| 2018 |
Elkamhawy A, Park JE, Hassan AHE, Pae AN, Lee J, Paik S, Park BG, Roh EJ. Pyrazinyl ureas revisited: 1-(3-(Benzyloxy)pyrazin-2-yl)-3-(3,4-dichlorophenyl)urea, a new blocker of Aβ-induced mPTP opening for Alzheimer's disease. European Journal of Medicinal Chemistry. 157: 268-278. PMID 30098482 DOI: 10.1016/J.Ejmech.2018.07.068 |
0.339 |
|
| 2018 |
Yoon S, Zuo D, Kim JH, Yoon I, Ann J, Kim SE, Cho D, Kim WK, Lee S, Lee J, Kim S, Lee J. Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors. Bioorganic & Medicinal Chemistry. PMID 30041947 DOI: 10.1016/J.Bmc.2018.06.034 |
0.446 |
|
| 2018 |
Ngo VTH, Hoang VH, Tran PT, Van Manh N, Ann J, Kim E, Cui M, Choi S, Lee J, Kim H, Ha HJ, Choi K, Kim YH, Lee J. Structure-activity relationship investigation of Phe-Arg mimetic region of human glutaminyl cyclase inhibitors. Bioorganic & Medicinal Chemistry. PMID 29705377 DOI: 10.1016/J.Bmc.2018.04.040 |
0.394 |
|
| 2018 |
Nam HY, Hong JA, Choi J, Shin S, Cho SK, Seo J, Lee J. Mitochondria-targeting peptoids. Bioconjugate Chemistry. PMID 29578690 DOI: 10.1021/Acs.Bioconjchem.8B00148 |
0.366 |
|
| 2018 |
Ngo VTH, Hoang VH, Tran PT, Ann J, Cui M, Park G, Choi S, Lee J, Kim H, Ha HJ, Choi K, Kim YH, Lee J. Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer's agents: Structure-activity relationship study of Arg-mimetic region. Bioorganic & Medicinal Chemistry. PMID 29398442 DOI: 10.1016/J.Bmc.2018.01.015 |
0.372 |
|
| 2018 |
Kim SM, Lee M, Lee SY, Lee SM, Kim EJ, Kim JS, Ann J, Lee J, Lee J. Synthesis and biological evaluation of 3-(2-aminoethyl) uracil derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists. European Journal of Medicinal Chemistry. 145: 413-424. PMID 29335207 DOI: 10.1016/J.Ejmech.2017.12.095 |
0.353 |
|
| 2017 |
Elkamhawy A, Park JE, Hassan AHE, Pae AN, Lee J, Park BG, Roh EJ. Synthesis and evaluation of 2-(3-arylureido)pyridines and 2-(3-arylureido)pyrazines as potential modulators of Aβ-induced mitochondrial dysfunction in Alzheimer's disease. European Journal of Medicinal Chemistry. 144: 529-543. PMID 29288949 DOI: 10.1016/J.Ejmech.2017.12.045 |
0.342 |
|
| 2017 |
Lee J, Kang D, Choi J, Huang W, Wadman M, Barron AE, Seo J. Effect of side chain hydrophobicity and cationic charge on antimicrobial activity and cytotoxicity of helical peptoids. Bioorganic & Medicinal Chemistry Letters. PMID 29198866 DOI: 10.1016/J.Bmcl.2017.11.034 |
0.312 |
|
| 2017 |
Ha H, Kang DW, Kim HM, Kang JM, Ann J, Hyun HJ, Lee JH, Kim SH, Kim H, Choi K, Hong HS, Kim YH, Jo DG, Lee J, Lee J. Discovery of an Orally Bioavailable Benzofuran Analogue that Serves as a β-amyloid Aggregation Inhibitor for the Potential Treatment of Alzheimer's Disease. Journal of Medicinal Chemistry. PMID 29161514 DOI: 10.1021/Acs.Jmedchem.7B00844 |
0.301 |
|
| 2017 |
Park JE, Elkamhawy A, Hassan AHE, Pae AN, Lee J, Paik S, Park BG, Roh EJ. Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-β-induced toxicity. European Journal of Medicinal Chemistry. 141: 322-334. PMID 29031076 DOI: 10.1016/J.Ejmech.2017.09.043 |
0.334 |
|
| 2017 |
Kim T, Son WS, Morshed MN, Londhe AM, Jung SY, Park JH, Park WK, Lim SM, Park KD, Cho SJ, Jeong KS, Lee J, Pae AN. Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity. European Journal of Medicinal Chemistry. 141: 240-256. PMID 29031071 DOI: 10.1016/J.Ejmech.2017.09.033 |
0.349 |
|
| 2017 |
Park I, Londhe AM, Lim JW, Park BG, Jung SY, Lee JY, Lim SM, No KT, Lee J, Pae AN. Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction. Journal of Computer-Aided Molecular Design. PMID 28913661 DOI: 10.1007/S10822-017-0067-9 |
0.39 |
|
| 2017 |
Yoon S, Kim JH, Koh Y, Tran PT, Ann J, Yoon I, Jang J, Kim WK, Lee S, Lee J, Kim S, Lee J. Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors. Bioorganic & Medicinal Chemistry. PMID 28625715 DOI: 10.1016/J.Bmc.2017.06.002 |
0.424 |
|
| 2017 |
Elkamhawy A, Park JE, Hassan AHE, Pae AN, Lee J, Park BG, Paik S, Do J, Park JH, Park KD, Moon B, Park WK, Cho H, Jeong DY, Roh EJ. Design, synthesis, biological evaluation and molecular modelling of 2-(2-aryloxyphenyl)-1,4-dihydroisoquinolin-3(2H)-ones: A novel class of TSPO ligands modulating amyloid-β-induced mPTP opening. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 28435076 DOI: 10.1016/J.Ejps.2017.04.015 |
0.361 |
|
| 2017 |
Hoang VH, Tran PT, Cui M, Ngo VT, Ann J, Park J, Lee J, Choi K, Cho H, Kim H, Ha H, Hong HS, Choi S, Kim YH, Lee J. Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents based on Rational Design. Journal of Medicinal Chemistry. PMID 28234463 DOI: 10.1021/Acs.Jmedchem.7B00098 |
0.343 |
|
| 2016 |
Elkamhawy A, Park JE, Hassan AH, Ra H, Pae AN, Lee J, Park BG, Moon B, Park HM, Roh EJ. Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction. European Journal of Medicinal Chemistry. 128: 56-69. PMID 28152427 DOI: 10.1016/J.Ejmech.2016.12.057 |
0.345 |
|
| 2016 |
Yoon S, Kim JH, Kim SE, Kim C, Tran PT, Ann J, Koh Y, Jang J, Kim S, Moon HS, Kim WK, Lee S, Lee J, Kim S, Lee J. Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-Targeted Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors. Journal of Medicinal Chemistry. 59: 10322-10328. PMID 27933890 DOI: 10.1021/acs.jmedchem.6b01190 |
0.304 |
|
| 2016 |
Kim T, Yang HY, Park BG, Jung SY, Park JH, Park KD, Min SJ, Tae J, Yang H, Cho S, Cho SJ, Song H, Mook-Jung I, Lee J, Pae AN. Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease. European Journal of Medicinal Chemistry. 125: 1172-1192. PMID 27855359 DOI: 10.1016/J.Ejmech.2016.11.017 |
0.354 |
|
| 2016 |
Kim SM, Lee M, Lee SY, Park E, Lee SM, Kim EJ, Han MY, Yoo T, Ann J, Yoon S, Lee J, Lee J. Discovery of an Orally Bioavailable Gonadotropin-releasing Hormone (GnRH) Receptor Antagonist. Journal of Medicinal Chemistry. PMID 27608177 DOI: 10.1021/Acs.Jmedchem.6B01071 |
0.318 |
|
| 2016 |
Yoon S, Kim JH, Yoon I, Kim C, Kim SE, Koh Y, Jeong SJ, Lee J, Kim S, Lee J. Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase (LRS)-targeted mTORC1 inhibitor. Bioorganic & Medicinal Chemistry Letters. PMID 27209231 DOI: 10.1016/J.Bmcl.2016.05.011 |
0.416 |
|
| 2015 |
Cho NC, Cha JH, Kim H, Kwak J, Kim D, Seo SH, Shin JS, Kim T, Park KD, Lee J, No KT, Kim YK, Lee KT, Pae AN. Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists. Bioorganic & Medicinal Chemistry. PMID 26631441 DOI: 10.1016/J.Bmc.2015.11.016 |
0.318 |
|
| 2015 |
Lee HR, Farhanullah SN, Lee J, Jajoo R, Kong SY, Shin JY, Kim JO, Lee J, Lee J, Kim HJ. Discovery of a Small Molecule that Enhances Astrocytogenesis by Activation of STAT3, SMAD1/5/8 and ERK1/2 via Induction of Cytokines in Neural Stem Cells. Acs Chemical Neuroscience. PMID 26505647 DOI: 10.1021/Acschemneuro.5B00243 |
0.326 |
|
| 2015 |
Choi K, Lim KS, Shin J, Kim SH, Suh YG, Hong HS, Kim H, Ha HJ, Kim YH, Lee J, Lee J. 6-Phenoxy-2-phenylbenzoxazoles, novel inhibitors of receptor for advanced glycation end products (RAGE). Bioorganic & Medicinal Chemistry. 23: 4919-35. PMID 26051601 DOI: 10.1016/J.Bmc.2015.05.022 |
0.3 |
|
| 2015 |
Nam M, Kim T, Kwak J, Seo SH, Ko MK, Lim EJ, Min SJ, Cho YS, Keum G, Baek DJ, Lee J, Pae AN. Discovery and biological evaluation of tetrahydrothieno[2,3-c]pyridine derivatives as selective metabotropic glutamate receptor 1 antagonists for the potential treatment of neuropathic pain. European Journal of Medicinal Chemistry. 97: 245-58. PMID 25984841 DOI: 10.1016/J.Ejmech.2015.04.060 |
0.309 |
|
| 2014 |
Elkamhawy A, Lee J, Park BG, Park I, Pae AN, Roh EJ. Novel quinazoline-urea analogues as modulators for Aβ-induced mitochondrial dysfunction: design, synthesis, and molecular docking study. European Journal of Medicinal Chemistry. 84: 466-75. PMID 25050879 DOI: 10.1016/J.Ejmech.2014.07.027 |
0.378 |
|
| 2013 |
Choi MJ, No ES, Thorat DA, Jang JW, Yang H, Lee J, Choo H, Kim SJ, Lee CS, Ko SY, Lee J, Nam G, Pae AN. Synthesis and biological evaluation of aryloxazole derivatives as antimitotic and vascular-disrupting agents for cancer therapy. Journal of Medicinal Chemistry. 56: 9008-18. PMID 24160376 DOI: 10.1021/Jm400840P |
0.344 |
|
| 2013 |
Yoon HJ, Kong SY, Park MH, Cho Y, Kim SE, Shin JY, Jung S, Lee J, Farhanullah, Kim HJ, Lee J. Aminopropyl carbazole analogues as potent enhancers of neurogenesis. Bioorganic & Medicinal Chemistry. 21: 7165-74. PMID 24095011 DOI: 10.1016/J.Bmc.2013.08.066 |
0.304 |
|
| 2013 |
Morell M, Nguyen Duc T, Willis AL, Syed S, Lee J, Deu E, Deng Y, Xiao J, Turk BE, Jessen JR, Weiss SJ, Bogyo M. Coupling protein engineering with probe design to inhibit and image matrix metalloproteinases with controlled specificity. Journal of the American Chemical Society. 135: 9139-48. PMID 23701445 DOI: 10.1021/Ja403523P |
0.318 |
|
| 2013 |
Tran PT, Hoang VH, Thorat SA, Kim SE, Ann J, Chang YJ, Nam DW, Song H, Mook-Jung I, Lee J, Lee J. Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template. Bioorganic & Medicinal Chemistry. 21: 3821-30. PMID 23643900 DOI: 10.1016/J.Bmc.2013.04.005 |
0.352 |
|
| 2013 |
Kim YS, Jung SH, Park BG, Ko MK, Jang HS, Choi K, Baik JH, Lee J, Lee JK, Pae AN, Cho YS, Min SJ. Synthesis and evaluation of oxime derivatives as modulators for amyloid beta-induced mitochondrial dysfunction. European Journal of Medicinal Chemistry. 62: 71-83. PMID 23353734 DOI: 10.1016/J.Ejmech.2012.12.033 |
0.341 |
|
| 2013 |
Lee J, Bogyo M. Target deconvolution techniques in modern phenotypic profiling. Current Opinion in Chemical Biology. 17: 118-26. PMID 23337810 DOI: 10.1016/J.Cbpa.2012.12.022 |
0.332 |
|
| 2013 |
Edgington LE, Verdoes M, Ortega A, Withana NP, Lee J, Syed S, Bachmann MH, Blum G, Bogyo M. Functional imaging of legumain in cancer using a new quenched activity-based probe. Journal of the American Chemical Society. 135: 174-82. PMID 23215039 DOI: 10.1021/Ja307083B |
0.332 |
|
| 2012 |
Lee J, Bogyo M. Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain. Bioorganic & Medicinal Chemistry Letters. 22: 1340-3. PMID 22243962 DOI: 10.1016/J.Bmcl.2011.12.079 |
0.346 |
|
| 2012 |
Lee J. Cobalt (III) complexes as novel matrix metalloproteinase-9 inhibitors Bulletin of the Korean Chemical Society. 33: 2762-2764. DOI: 10.5012/Bkcs.2012.33.8.2762 |
0.422 |
|
| 2010 |
Lee J, Bogyo M. Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain. Acs Chemical Biology. 5: 233-43. PMID 20017516 DOI: 10.1021/Cb900232A |
0.353 |
|
| 2009 |
Harney AS, Lee J, Manus LM, Wang P, Ballweg DM, LaBonne C, Meade TJ. Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate. Proceedings of the National Academy of Sciences of the United States of America. 106: 13667-72. PMID 19666616 DOI: 10.1073/Pnas.0906423106 |
0.515 |
|
| 2007 |
Lee J, Burdette JE, MacRenaris KW, Mustafi D, Woodruff TK, Meade TJ. Rational design, synthesis, and biological evaluation of progesterone-modified MRI contrast agents. Chemistry & Biology. 14: 824-34. PMID 17656319 DOI: 10.1016/J.Chembiol.2007.06.006 |
0.703 |
|
| 2005 |
Lee J, Zylka MJ, Anderson DJ, Burdette JE, Woodruff TK, Meade TJ. A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling. Journal of the American Chemical Society. 127: 13164-6. PMID 16173742 DOI: 10.1021/Ja051294X |
0.545 |
|
| 2004 |
Lee J, Kim SY, Lee J, Kang M, Kil MJ, Choi HK, Jin MK, Wang Y, Toth A, Pearce LV, Lundberg DJ, Tran R, Blumberg PM. Analysis of structure-activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism. Bioorganic & Medicinal Chemistry. 12: 3411-20. PMID 15186827 DOI: 10.1016/J.Bmc.2004.04.040 |
0.322 |
|
| 2004 |
Lee J, Kang SU, Choi HK, Lee J, Lim JO, Kil MJ, Jin MK, Kim KP, Sung JH, Chung SJ, Ha HJ, Kim YH, Pearce LV, Tran R, Lundberg DJ, et al. Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity. Bioorganic & Medicinal Chemistry Letters. 14: 2291-7. PMID 15081027 DOI: 10.1016/J.Bmcl.2004.02.002 |
0.305 |
|
| 2004 |
Lee J, Kim SY, Park S, Lim JO, Kim JM, Kang M, Lee J, Kang SU, Choi HK, Jin MK, Welter JD, Szabo T, Tran R, Pearce LV, Toth A, et al. Structure-activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding. Bioorganic & Medicinal Chemistry. 12: 1055-69. PMID 14980619 DOI: 10.1016/J.Bmc.2003.12.005 |
0.307 |
|
| 2003 |
Wang Y, Toth A, Tran R, Szabo T, Welter JD, Blumberg PM, Lee J, Kang SU, Lim JO, Lee J. High-affinity partial agonists of the vanilloid receptor. Molecular Pharmacology. 64: 325-33. PMID 12869637 DOI: 10.1124/Mol.64.2.325 |
0.352 |
|
| 2003 |
Lee J, Lee J, Kang M, Shin M, Kim JM, Kang SU, Lim JO, Choi HK, Suh YG, Park HG, Oh U, Kim HD, Park YH, Ha HJ, Kim YH, et al. N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor. Journal of Medicinal Chemistry. 46: 3116-26. PMID 12825950 DOI: 10.1021/Jm030089U |
0.323 |
|
| 2002 |
Lee J, Lee J, Kang MS, Kim KP, Chung SJ, Blumberg PM, Yi JB, Park YH. Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics. Bioorganic & Medicinal Chemistry. 10: 1171-9. PMID 11836128 DOI: 10.1016/S0968-0896(01)00387-X |
0.315 |
|
| 2001 |
Lee J, Lee J, Szabo T, Gonzalez AF, Welter JD, Blumberg PM. N-(3-acyloxy-2-benzylpropyl)-N'-dihydroxytetrahydrobenzazepine and tetrahydroisoquinoline thiourea analogues as vanilloid receptor ligands. Bioorganic & Medicinal Chemistry. 9: 1713-20. PMID 11425572 DOI: 10.1016/S0968-0896(01)00068-2 |
0.339 |
|
| 2001 |
Lee J, Lee J, Kim J, Kim SY, Chun MW, Cho H, Hwang SW, Oh U, Park YH, Marquez VE, Beheshti M, Szabo T, Blumberg PM. N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics. Bioorganic & Medicinal Chemistry. 9: 19-32. PMID 11197340 DOI: 10.1016/S0968-0896(00)00216-9 |
0.361 |
|
| 1999 |
Lee J, Park SU, Kim JY, Kim JK, Lee J, Oh U, Marquez VE, Beheshti M, Wang QJ, Modarres S, Blumberg PM. 3-Acyloxy-2-phenalkylpropyl amides and esters of homovanillic acid as novel vanilloid receptor agonists. Bioorganic & Medicinal Chemistry Letters. 9: 2909-14. PMID 10571146 DOI: 10.1016/S0960-894X(99)00513-2 |
0.303 |
|
| 1999 |
Chun KS, Sohn Y, Kim HS, Kim OH, Park KK, Lee JM, Lee J, Lee JY, Moon A, Lee SS, Surh YJ. Anti-tumor promoting potential of naturally occurring diarylheptanoids structurally related to curcumin Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 428: 49-57. PMID 10517978 DOI: 10.1016/S1383-5742(99)00031-9 |
0.315 |
|
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