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Kevin W. Williams, Ph.D. - Publications

Affiliations: 
2001-2006 Neuroscience Tulane University, New Orleans, LA, United States 
 2006- Internal Medicine - Division of Hypothalamic Research University of Texas Southwestern Medical Center, Dallas, TX, United States 
Website:
http://www.utsouthwestern.edu/labs/williams/
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65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Quarta C, Claret M, Zeltser LM, Williams KW, Yeo GSH, Tschöp MH, Diano S, Brüning JC, Cota D. POMC neuronal heterogeneity in energy balance and beyond: an integrated view. Nature Metabolism. PMID 33633406 DOI: 10.1038/s42255-021-00345-3  0.517
2020 Sun N, Shen C, Zhang L, Wu X, Yu Y, Yang X, Yang C, Zhong C, Gao Z, Miao W, Yang Z, Gao W, Hu L, Williams K, Liu C, et al. Hepatic Krüppel-like factor 16 (KLF16) targets PPARα to improve steatohepatitis and insulin resistance. Gut. PMID 33257471 DOI: 10.1136/gutjnl-2020-321774  0.373
2020 Lieu L, Chau D, Afrin S, Dong Y, Alhadeff AL, Betley JN, Williams KW. Effects of metabolic state on the regulation of melanocortin circuits. Physiology & Behavior. 113039. PMID 32610101 DOI: 10.1016/J.Physbeh.2020.113039  0.805
2020 Michael NJ, Zigman JM, Williams KW, Elmquist JK. Electrophysiological Properties of Genetically Identified Histaminergic Neurons. Neuroscience. PMID 32599122 DOI: 10.1016/J.Neuroscience.2020.06.031  0.844
2020 Pydi SP, Cui Z, He Z, Barella LF, Pham J, Cui Y, Oberlin DJ, Egritag HE, Urs N, Gavrilova O, Schwartz GJ, Buettner C, Williams KW, Wess J. Beneficial metabolic role of β-arrestin-1 expressed by AgRP neurons. Science Advances. 6: eaaz1341. PMID 32537493 DOI: 10.1126/Sciadv.Aaz1341  0.854
2020 Gao Z, Zhang J, Wei L, Yang X, Zhang Y, Cheng B, Yang Z, Gao W, Song C, Miao W, Williams K, Liu C, Xu Q, Chang Y, Gao Y. The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury. Oxidative Medicine and Cellular Longevity. 2020: 8026838. PMID 32454943 DOI: 10.1155/2020/8026838  0.544
2020 Torz LJ, Osborne-Lawrence S, Rodriguez J, He Z, Cornejo MP, Mustafá ER, Jin C, Petersen N, Hedegaard MA, Nybo M, Damonte VM, Metzger NP, Mani BK, Williams KW, Raingo J, et al. Metabolic insights from a GHSR-A203E mutant mouse model. Molecular Metabolism. 101004. PMID 32339772 DOI: 10.1016/J.Molmet.2020.101004  0.796
2020 Michael NJ, Caron A, Lee CE, Castorena CM, Lee S, Zigman JM, Williams KW, Elmquist JK. Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors. Molecular Metabolism. 35: 100956. PMID 32244183 DOI: 10.1016/J.Molmet.2020.01.020  0.846
2020 Park S, Williams KW, Liu C, Sohn JW. A neural basis for tonic suppression of sodium appetite. Nature Neuroscience. PMID 31959933 DOI: 10.1038/S41593-019-0573-2  0.715
2019 Zhao S, Zhu Y, Schultz RD, Li N, He Z, Zhang Z, Caron A, Zhu Q, Sun K, Xiong W, Deng H, Sun J, Deng Y, Kim M, Lee CE, ... ... Williams KW, et al. Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy. Cell Metabolism. PMID 31495688 DOI: 10.1016/J.Cmet.2019.08.005  0.802
2019 He Z, Gao Y, Lieu L, Afrin S, Cao J, Michael NJ, Dong Y, Sun J, Guo H, Williams KW. Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons - Implications for energy balance and glucose control. Molecular Metabolism. PMID 31446151 DOI: 10.1016/J.Molmet.2019.07.008  0.822
2019 Mani BK, Puzziferri N, He Z, Rodriguez JA, Osborne-Lawrence S, Metzger NP, Chhina N, Gaylinn B, Thorner MO, Thomas EL, Bell JD, Williams KW, Goldstone AP, Zigman JM. LEAP2 changes with body mass and food intake in humans and mice. The Journal of Clinical Investigation. PMID 31424424 DOI: 10.1172/Jci125332  0.823
2019 Kaneko K, Fu Y, Lin HY, Cordonier EL, Mo Q, Gao Y, Yao T, Naylor J, Howard V, Saito K, Xu P, Chen SS, Chen MH, Xu Y, Williams KW, et al. Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition. The Journal of Clinical Investigation. 130. PMID 31403469 DOI: 10.1172/Jci126107  0.722
2019 Ratner C, He Z, Grunddal KV, Skov LJ, Hartmann B, Zhang F, Feuchtinger A, Bjerregaard A, Christoffersen C, Tschöp MH, Finan B, DiMarchi RD, Leinninger GM, Williams KW, Clemmensen C, et al. Long Acting Neurotensin Synergizes with Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway. Diabetes. PMID 30936142 DOI: 10.2337/Db18-1009  0.783
2018 He Z, Gao Y, Lieu L, Afrin S, Guo H, Williams KW. Acute effects of zinc and insulin on arcuate anorexigenic Proopiomelanocortin (POMC) neurons. British Journal of Pharmacology. PMID 30521677 DOI: 10.1111/Bph.14559  0.831
2018 Wei Q, Gu YF, Zhang QJ, Yu H, Peng Y, Williams KW, Wang R, Yu K, Liu T, Liu ZP. Lztfl1/BBS17 controls energy homeostasis by regulating the leptin signaling in the hypothalamic neurons. Journal of Molecular Cell Biology. 10: 402-410. PMID 30423168 DOI: 10.1093/Jmcb/Mjy022  0.438
2018 He Z, Gao Y, Alhadeff AL, Castorena CM, Huang Y, Lieu L, Afrin S, Sun J, Betley JN, Guo H, Williams KW. Cellular and synaptic reorganization of arcuate NPY/AgRP and POMC neurons after exercise. Molecular Metabolism. PMID 30292523 DOI: 10.1016/J.Molmet.2018.08.011  0.818
2018 Huang Y, He Z, Gao Y, Lieu L, Yao T, Sun J, Liu T, Javadi C, Box M, Afrin S, Guo H, Williams KW. Phosphoinositide 3-Kinase Is Integral for the Acute Activity of Leptin and Insulin in Male Arcuate NPY/AgRP Neurons. Journal of the Endocrine Society. 2: 518-532. PMID 29850651 DOI: 10.1210/Js.2018-00061  0.84
2017 Mosialou I, Shikhel S, Liu JM, Maurizi A, Luo N, He Z, Huang Y, Zong H, Friedman RA, Barasch J, Lanzano P, Deng L, Leibel RL, Rubin M, Nickolas T, ... ... Williams KW, et al. Corrigendum: MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature. 546: 440. PMID 28617454 DOI: 10.1038/Nature22808  0.742
2017 Shen WJ, Yao T, Kong X, Williams KW, Liu T. Melanocortin neurons: multiple routes to regulation of metabolism. Biochimica Et Biophysica Acta. PMID 28499988 DOI: 10.1016/J.Bbadis.2017.05.007  0.634
2017 Mosialou I, Shikhel S, Liu JM, Maurizi A, Luo N, He Z, Huang Y, Zong H, Friedman RA, Barasch J, Lanzano P, Deng L, Leibel RL, Rubin M, Nicholas T, ... ... Williams KW, et al. MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature. PMID 28273060 DOI: 10.1038/Nature21697  0.811
2017 Kong X, Williams KW, Liu T. Genetic Mouse Models: The Powerful Tools to Study Fat Tissues. Methods in Molecular Biology (Clifton, N.J.). 1566: 99-107. PMID 28244044 DOI: 10.1007/978-1-4939-6820-6_10  0.334
2017 Gaykema RP, Newmyer BA, Ottolini M, Raje V, Warthen DM, Lambeth PS, Niccum M, Yao T, Huang Y, Schulman IG, Harris TE, Patel MK, Williams KW, Scott MM. Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight. The Journal of Clinical Investigation. PMID 28218622 DOI: 10.1172/Jci81335  0.85
2017 Gao Y, Yao T, Deng Z, Sohn JW, Sun J, Huang Y, Kong X, Yu KJ, Wang RT, Chen H, Guo H, Yan J, Cunningham KA, Chang Y, Liu T, ... Williams KW, et al. TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons. Cell Reports. 18: 583-592. PMID 28099839 DOI: 10.1016/J.Celrep.2016.12.072  0.86
2016 Yao T, Deng Z, Gao Y, Sun J, Kong X, Huang Y, He Z, Xu Y, Chang Y, Yu KJ, Findley BG, Berglund ED, Wang RT, Guo H, Chen H, ... ... Williams KW, et al. Ire1α in Pomc Neurons is Required for Thermogenesis and Glycemia. Diabetes. PMID 28028078 DOI: 10.2337/Db16-0533  0.851
2016 Sun J, Gao Y, Yao T, Huang Y, He Z, Kong X, Yu KJ, Wang RT, Guo H, Yan J, Chang Y, Chen H, Scherer PE, Liu T, Williams KW. Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons. Molecular Metabolism. 5: 882-91. PMID 27689001 DOI: 10.1016/J.Molmet.2016.08.007  0.853
2016 Sohn JW, Oh Y, Kim KW, Lee S, Williams KW, Elmquist JK. Leptin and insulin engage specific PI3K subunits in hypothalamic SF1 neurons. Molecular Metabolism. 5: 669-79. PMID 27656404 DOI: 10.1016/j.molmet.2016.06.004  0.799
2016 Zhu Y, Gao Y, Tao C, Shao M, Zhao S, Huang W, Yao T, Johnson JA, Liu T, Cypess AM, Gupta O, Holland WL, Gupta RK, Spray DC, Tanowitz HB, ... ... Williams KW, et al. Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. Cell Metabolism. 24: 420-433. PMID 27626200 DOI: 10.1016/J.Cmet.2016.08.005  0.785
2015 Yang D, Liu T, Williams KW. Motivation to Eat-AgRP Neurons and Homeostatic Need. Cell Metabolism. 22: 62-3. PMID 26154054 DOI: 10.1016/j.cmet.2015.06.018  0.512
2015 Gautron L, Elmquist JK, Williams KW. Neural control of energy balance: translating circuits to therapies. Cell. 161: 133-45. PMID 25815991 DOI: 10.1016/j.cell.2015.02.023  0.573
2014 Scott MM, Xu Y, Elias CF, Williams KW. Central regulation of food intake, body weight, energy expenditure, and glucose homeostasis. Frontiers in Neuroscience. 8: 384. PMID 25520610 DOI: 10.3389/Fnins.2014.00384  0.42
2014 Williams KW, Liu T, Kong X, Fukuda M, Deng Y, Berglund ED, Deng Z, Gao Y, Liu T, Sohn JW, Jia L, Fujikawa T, Kohno D, Scott MM, Lee S, et al. Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell Metabolism. 20: 471-82. PMID 25017942 DOI: 10.1016/J.Cmet.2014.06.002  0.86
2014 Berglund ED, Liu T, Kong X, Sohn JW, Vong L, Deng Z, Lee CE, Lee S, Williams KW, Olson DP, Scherer PE, Lowell BB, Elmquist JK. Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia. Nature Neuroscience. 17: 911-3. PMID 24908101 DOI: 10.1038/Nn.3737  0.864
2014 Frazao R, Dungan Lemko HM, da Silva RP, Ratra DV, Lee CE, Williams KW, Zigman JM, Elias CF. Estradiol modulates Kiss1 neuronal response to ghrelin. American Journal of Physiology. Endocrinology and Metabolism. 306: E606-14. PMID 24473434 DOI: 10.1152/Ajpendo.00211.2013  0.735
2014 Berglund ED, Liu C, Sohn JW, Liu T, Kim MH, Lee CE, Vianna CR, Williams KW, Xu Y, Elmquist JK. Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis (Journal of Clinical Investigation (2014) 124, 4 (1868) DOI: 10.1172/JCI75669) Journal of Clinical Investigation. 124: 1868.  0.725
2013 Berglund ED, Liu C, Sohn JW, Liu T, Kim MH, Lee CE, Vianna CR, Williams KW, Xu Y, Elmquist JK. Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis. The Journal of Clinical Investigation. 123: 5061-70. PMID 24177424 DOI: 10.1172/Jci70338  0.8
2013 Liu T, Elmquist JK, Williams KW. Mrap2: an accessory protein linked to obesity. Cell Metabolism. 18: 309-11. PMID 24011068 DOI: 10.1016/j.cmet.2013.08.016  0.557
2013 Sohn JW, Elmquist JK, Williams KW. Neuronal circuits that regulate feeding behavior and metabolism. Trends in Neurosciences. 36: 504-12. PMID 23790727 DOI: 10.1016/j.tins.2013.05.003  0.732
2013 Cravo RM, Frazao R, Perello M, Osborne-Lawrence S, Williams KW, Zigman JM, Vianna C, Elias CF. Leptin signaling in Kiss1 neurons arises after pubertal development. Plos One. 8: e58698. PMID 23505551 DOI: 10.1371/Journal.Pone.0058698  0.715
2013 Frazão R, Cravo RM, Donato J, Ratra DV, Clegg DJ, Elmquist JK, Zigman JM, Williams KW, Elias CF. Shift in Kiss1 cell activity requires estrogen receptor α. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 2807-20. PMID 23407940 DOI: 10.1523/Jneurosci.1610-12.2013  0.787
2013 Sohn JW, Harris LE, Berglund ED, Liu T, Vong L, Lowell BB, Balthasar N, Williams KW, Elmquist JK. Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Cell. 152: 612-9. PMID 23374353 DOI: 10.1016/j.cell.2012.12.022  0.872
2012 Williams KW, Elmquist JK. From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior. Nature Neuroscience. 15: 1350-5. PMID 23007190 DOI: 10.1038/nn.3217  0.571
2012 Cui H, Sohn JW, Gautron L, Funahashi H, Williams KW, Elmquist JK, Lutter M. Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area. The Journal of Comparative Neurology. 520: 4168-83. PMID 22605619 DOI: 10.1002/cne.23145  0.746
2012 Sohn JW, Williams KW. Functional heterogeneity of arcuate nucleus pro-opiomelanocortin neurons: implications for diverging melanocortin pathways. Molecular Neurobiology. 45: 225-33. PMID 22328135 DOI: 10.1007/s12035-012-8240-6  0.746
2011 Williams KW, Sohn JW, Donato J, Lee CE, Zhao JJ, Elmquist JK, Elias CF. The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 13147-56. PMID 21917798 DOI: 10.1523/JNEUROSCI.2602-11.2011  0.784
2011 Sohn JW, Xu Y, Jones JE, Wickman K, Williams KW, Elmquist JK. Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron. 71: 488-97. PMID 21835345 DOI: 10.1016/J.Neuron.2011.06.012  0.747
2011 Klöckener T, Hess S, Belgardt BF, Paeger L, Verhagen LA, Husch A, Sohn JW, Hampel B, Dhillon H, Zigman JM, Lowell BB, Williams KW, Elmquist JK, Horvath TL, Kloppenburg P, et al. High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nature Neuroscience. 14: 911-8. PMID 21642975 DOI: 10.1038/Nn.2847  0.833
2011 Scott MM, Williams KW, Rossi J, Lee CE, Elmquist JK. Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice. The Journal of Clinical Investigation. 121: 2413-21. PMID 21606595 DOI: 10.1172/JCI43703  0.705
2011 Fukuda M, Williams KW, Gautron L, Elmquist JK. Induction of leptin resistance by activation of cAMP-Epac signaling. Cell Metabolism. 13: 331-9. PMID 21356522 DOI: 10.1016/j.cmet.2011.01.016  0.63
2011 Williams KW, Elmquist JK. Lighting up the hypothalamus: coordinated control of feeding behavior. Nature Neuroscience. 14: 277-8. PMID 21346745 DOI: 10.1038/nn0311-277  0.615
2011 Williams KW, Scott MM, Elmquist JK. Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network. European Journal of Pharmacology. 660: 2-12. PMID 21211525 DOI: 10.1016/j.ejphar.2010.11.042  0.671
2011 Kim KW, Sohn JW, Kohno D, Xu Y, Williams K, Elmquist JK. SF-1 in the ventral medial hypothalamic nucleus: a key regulator of homeostasis. Molecular and Cellular Endocrinology. 336: 219-23. PMID 21111025 DOI: 10.1016/J.Mce.2010.11.019  0.755
2010 Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nature Neuroscience. 13: 1457-9. PMID 21037584 DOI: 10.1038/Nn.2664  0.779
2010 Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, et al. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metabolism. 11: 286-97. PMID 20374961 DOI: 10.1016/J.Cmet.2010.03.002  0.839
2010 Williams KW, Margatho LO, Lee CE, Choi M, Lee S, Scott MM, Elias CF, Elmquist JK. Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2472-9. PMID 20164331 DOI: 10.1523/JNEUROSCI.3118-09.2010  0.706
2009 Gao H, Glatzer NR, Williams KW, Derbenev AV, Liu D, Smith BN. Morphological and electrophysiological features of motor neurons and putative interneurons in the dorsal vagal complex of rats and mice. Brain Research. 1291: 40-52. PMID 19619517 DOI: 10.1016/J.Brainres.2009.07.024  0.823
2009 Williams KW, Scott MM, Elmquist JK. From observation to experimentation: leptin action in the mediobasal hypothalamus. The American Journal of Clinical Nutrition. 89: 985S-990S. PMID 19176744 DOI: 10.3945/ajcn.2008.26788D  0.665
2008 Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron. 60: 582-9. PMID 19038216 DOI: 10.1016/J.Neuron.2008.09.033  0.824
2008 Ramadori G, Lee CE, Bookout AL, Lee S, Williams KW, Anderson J, Elmquist JK, Coppari R. Brain SIRT1: anatomical distribution and regulation by energy availability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 9989-96. PMID 18829956 DOI: 10.1523/JNEUROSCI.3257-08.2008  0.628
2008 Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK. Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. The Journal of Clinical Investigation. 118: 1796-805. PMID 18382766 DOI: 10.1172/Jci32964  0.864
2007 Williams KW, Coppari R, Elmquist JK. "AMPing up" our understanding of the hypothalamic control of energy balance. The Journal of Clinical Investigation. 117: 2089-92. PMID 17671647 DOI: 10.1172/JCI32975  0.666
2007 Williams KW, Zsombok A, Smith BN. Rapid inhibition of neurons in the dorsal motor nucleus of the vagus by leptin. Endocrinology. 148: 1868-81. PMID 17194747 DOI: 10.1210/En.2006-1098  0.825
2006 Williams KW, Smith BN. Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: implications for ingestive behaviour. The Journal of Physiology. 573: 395-412. PMID 16581866 DOI: 10.1113/jphysiol.2006.106336  0.747
2004 Davis SF, Derbenev AV, Williams KW, Glatzer NR, Smith BN. Excitatory and inhibitory local circuit input to the rat dorsal motor nucleus of the vagus originating from the nucleus tractus solitarius. Brain Research. 1017: 208-17. PMID 15261116 DOI: 10.1016/J.Brainres.2004.05.049  0.818
2003 Davis SF, Williams KW, Xu W, Glatzer NR, Smith BN. Selective enhancement of synaptic inhibition by hypocretin (orexin) in rat vagal motor neurons: implications for autonomic regulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3844-54. PMID 12736355 DOI: 10.1523/Jneurosci.23-09-03844.2003  0.826
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