Year |
Citation |
Score |
2007 |
Barb AW, McClerren AL, Snehelatha K, Reynolds CM, Zhou P, Raetz CR. Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli. Biochemistry. 46: 3793-802. PMID 17335290 DOI: 10.1021/Bi6025165 |
0.687 |
|
2006 |
Mdluli KE, Witte PR, Kline T, Barb AW, Erwin AL, Mansfield BE, McClerren AL, Pirrung MC, Tumey LN, Warrener P, Raetz CR, Stover CK. Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 50: 2178-84. PMID 16723580 DOI: 10.1128/Aac.00140-06 |
0.666 |
|
2005 |
McClerren AL, Endsley S, Bowman JL, Andersen NH, Guan Z, Rudolph J, Raetz CR. A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin. Biochemistry. 44: 16574-83. PMID 16342948 DOI: 10.1021/Bi0518186 |
0.718 |
|
2005 |
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR. A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose. The Journal of Biological Chemistry. 280: 14154-67. PMID 15695810 DOI: 10.1074/Jbc.M414265200 |
0.603 |
|
2005 |
Coggins BE, McClerren AL, Jiang L, Li X, Rudolph J, Hindsgaul O, Raetz CR, Zhou P. Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design. Biochemistry. 44: 1114-26. PMID 15667205 DOI: 10.1021/Bi047820Z |
0.637 |
|
2005 |
McClerren AL, Zhou P, Guan Z, Raetz CR, Rudolph J. Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway. Biochemistry. 44: 1106-13. PMID 15667204 DOI: 10.1021/Bi048001H |
0.58 |
|
2005 |
Li X, McClerren AL, Raetz CRH, Hindsgaul O. Mapping the active site of the bacterial enzyme LpxC using novel carbohydrate-based hydroxamic acid inhibitors Journal of Carbohydrate Chemistry. 24: 583-609. DOI: 10.1081/Car-200068781 |
0.531 |
|
2003 |
Coggins BE, Li X, McClerren AL, Hindsgaul O, Raetz CR, Zhou P. Structure of the LpxC deacetylase with a bound substrate-analog inhibitor. Nature Structural Biology. 10: 645-51. PMID 12833153 DOI: 10.1038/Nsb948 |
0.651 |
|
2003 |
Pirrung MC, Tumey LN, McClerren AL, Raetz CR. High-throughput catch-and-release synthesis of oxazoline hydroxamates. Structure-activity relationships in novel inhibitors of Escherichia coli LpxC: in vitro enzyme inhibition and antibacterial properties. Journal of the American Chemical Society. 125: 1575-86. PMID 12568618 DOI: 10.1021/Ja0209114 |
0.641 |
|
2002 |
Pirrung MC, Tumey LN, Raetz CR, Jackman JE, Snehalatha K, McClerren AL, Fierke CA, Gantt SL, Rusche KM. Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups. Journal of Medicinal Chemistry. 45: 4359-70. PMID 12213077 DOI: 10.1021/Jm020183V |
0.673 |
|
Show low-probability matches. |