| Year |
Citation |
Score |
| 2015 |
De Sarro G, Russo E, Citraro R, Meldrum BS. Genetically epilepsy-prone rats (GEPRs) and DBA/2 mice: Two animal models of audiogenic reflex epilepsy for the evaluation of new generation AEDs. Epilepsy & Behavior : E&B. PMID 26254980 DOI: 10.1016/j.yebeh.2015.06.030 |
0.428 |
|
| 2010 |
Henshall DC, Meldrum BS. Cell death after single and repeated brief seizures Epilepsia. 51: 35. DOI: 10.1111/j.1528-1167.2010.02821.x |
0.407 |
|
| 2007 |
Meldrum BS, Rogawski MA. Molecular targets for antiepileptic drug development. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 4: 18-61. PMID 17199015 DOI: 10.1016/j.nurt.2006.11.010 |
0.51 |
|
| 2003 |
Moldrich RX, Chapman AG, De Sarro G, Meldrum BS. Glutamate metabotropic receptors as targets for drug therapy in epilepsy. European Journal of Pharmacology. 476: 3-16. PMID 12969743 DOI: 10.1016/S0014-2999(03)02149-6 |
0.341 |
|
| 2002 |
Kwan P, Sills GJ, Butler E, Gant TW, Meldrum BS, Brodie MJ. Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure. Epilepsia. 43: 1318-23. PMID 12423380 DOI: 10.1046/J.1528-1157.2002.156702.X |
0.441 |
|
| 2002 |
Meldrum B. Do preclinical seizure models preselect certain adverse effects of antiepileptic drugs Epilepsy Research. 50: 33-40. PMID 12151115 DOI: 10.1016/S0920-1211(02)00066-9 |
0.306 |
|
| 2002 |
Meldrum BS. Implications for neuroprotective treatments. Progress in Brain Research. 135: 487-95. PMID 12143367 DOI: 10.1016/S0079-6123(02)35046-5 |
0.416 |
|
| 2002 |
Meldrum BS. Concept of activity-induced cell death in epilepsy: historical and contemporary perspectives. Progress in Brain Research. 135: 3-11. PMID 12143350 DOI: 10.1016/S0079-6123(02)35003-9 |
0.413 |
|
| 2001 |
Meldrum BS. Why and when are seizures bad for the brain? Trends in Pharmacological Sciences. 22: 445-6. PMID 11592262 DOI: 10.1016/S0165-6147(00)01813-7 |
0.3 |
|
| 2001 |
Chapman AG, Talebi A, Yip PK, Meldrum BS. Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. European Journal of Pharmacology. 424: 107-13. PMID 11476756 DOI: 10.1016/S0014-2999(01)01013-5 |
0.421 |
|
| 2001 |
Moldrich RX, Jeffrey M, Talebi A, Beart PM, Chapman AG, Meldrum BS. Anti-epileptic activity of group II metabotropic glutamate receptor agonists (--)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (--)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795). Neuropharmacology. 41: 8-18. PMID 11445181 DOI: 10.1016/S0028-3908(01)00044-2 |
0.487 |
|
| 2001 |
Yip PK, Meldrum BS, Rattray M. Elevated levels of group-III metabotropic glutamate receptors in the inferior colliculus of genetically epilepsy-prone rats following intracollicular administration of L-serine-O-phosphate. Journal of Neurochemistry. 78: 13-23. PMID 11432969 DOI: 10.1046/j.1471-4159.2001.00418.x |
0.447 |
|
| 2001 |
Cash D, Beech JS, Rayne RC, Bath PM, Meldrum BS, Williams SC. Neuroprotective effect of aminoguanidine on transient focal ischaemia in the rat brain. Brain Research. 905: 91-103. PMID 11423083 DOI: 10.1016/S0006-8993(01)02508-2 |
0.317 |
|
| 2001 |
Moldrich RX, Beart PM, Jane DE, Chapman AG, Meldrum BS. Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology. 40: 732-5. PMID 11311902 DOI: 10.1016/S0028-3908(01)00002-8 |
0.422 |
|
| 2001 |
Moldrich RX, Talebi A, Beart PM, Chapman AG, Meldrum BS. The mGlu(2/3) agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate, is anti- and proconvulsant in DBA/2 mice. Neuroscience Letters. 299: 125-9. PMID 11166954 DOI: 10.1016/S0304-3940(00)01732-8 |
0.356 |
|
| 2000 |
Chapman AG, Nanan K, Williams M, Meldrum BS. Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893). Neuropharmacology. 39: 1567-74. PMID 10854901 DOI: 10.1016/S0028-3908(99)00242-7 |
0.351 |
|
| 2000 |
Meldrum BS, Chapman AG, Tang E, Keaney K, Patel S, Chadwick A, Hodges H. Cell grafts in epilepsy: Therapeutic prospects and problems Acta Neurologica Scandinavica, Supplement. 102: 46-47. DOI: 10.1034/J.1600-0404.2000.00202-25.X |
0.336 |
|
| 1999 |
Meldrum BS, Chapman AG. Basic mechanisms of gabitril (tiagabine) and future potential developments. Epilepsia. 40: S2-6. PMID 10612355 DOI: 10.1111/J.1528-1157.1999.Tb02087.X |
0.449 |
|
| 1999 |
Chapman AG, Nanan K, Yip P, Meldrum BS. Anticonvulsant activity of a metabotropic glutamate receptor 8 preferential agonist, (R,S)-4-phosphonophenylglycine. European Journal of Pharmacology. 383: 23-7. PMID 10556677 DOI: 10.1016/S0014-2999(99)00615-9 |
0.49 |
|
| 1999 |
Meldrum BS, Akbar MT, Chapman AG. Glutamate receptors and transporters in genetic and acquired models of epilepsy. Epilepsy Research. 36: 189-204. PMID 10515165 DOI: 10.1016/S0920-1211(99)00051-0 |
0.304 |
|
| 1999 |
Klapstein GJ, Meldrum BS, Mody I. Decreased sensitivity to Group III mGluR agonists in the lateral perforant path following kindling. Neuropharmacology. 38: 927-33. PMID 10428411 DOI: 10.1016/S0028-3908(99)00016-7 |
0.425 |
|
| 1999 |
Chapman AG, Yip PK, Yap JS, Quinn LP, Tang E, Harris JR, Meldrum BS. Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid). European Journal of Pharmacology. 368: 17-24. PMID 10096765 DOI: 10.1016/S0014-2999(99)00014-X |
0.472 |
|
| 1998 |
Akbar MT, Rattray M, Williams RJ, Chong NW, Meldrum BS. Reduction of GABA and glutamate transporter messenger RNAs in the severe-seizure genetically epilepsy-prone rat. Neuroscience. 85: 1235-51. PMID 9681960 DOI: 10.1016/S0306-4522(97)00684-2 |
0.414 |
|
| 1998 |
Escott KJ, Beech JS, Haga KK, Williams SC, Meldrum BS, Bath PM. Cerebroprotective effect of the nitric oxide synthase inhibitors, 1-(2-trifluoromethylphenyl) imidazole and 7-nitro indazole, after transient focal cerebral ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 18: 281-7. PMID 9498844 DOI: 10.1097/00004647-199803000-00006 |
0.308 |
|
| 1997 |
Dalby NO, Thomsen C, Fink-Jensen A, Lundbeck J, Søkilde B, Man CM, Sørensen PO, Meldrum B. Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1 Epilepsy Research. 28: 51-61. PMID 9255599 DOI: 10.1016/S0920-1211(97)00033-8 |
0.369 |
|
| 1997 |
Meldrum BS. First Alfred Meyer Memorial Lecture. Epileptic brain damage: a consequence and a cause of seizures. Neuropathology and Applied Neurobiology. 23: 185-201; discussion . PMID 9223128 |
0.328 |
|
| 1997 |
Tang E, Yip PK, Chapman AG, Jane DE, Meldrum BS. Prolonged anticonvulsant action of glutamate metabotropic receptor agonists in inferior colliculus of genetically epilepsy-prone rats. European Journal of Pharmacology. 327: 109-15. PMID 9200548 DOI: 10.1016/S0014-2999(97)89649-5 |
0.451 |
|
| 1997 |
Dürmüller N, Graham JL, Sowinski P, Meldrum BS. The vital dye Evans blue mimics limbic seizures induced by kainate or pilocarpine. Brain Research. 753: 283-90. PMID 9125413 DOI: 10.1016/S0006-8993(97)00032-2 |
0.404 |
|
| 1997 |
Meldrum BS. Excitatory amino acids—Clinical results with antagonists Neuropharmacology. 36: 1802. DOI: 10.1016/S0028-3908(97)00199-8 |
0.322 |
|
| 1996 |
Akbar MT, Rattray M, Powell JF, Meldrum BS. Altered expression of group I metabotropic glutamate receptors in the hippocampus of amygdala-kindled rats. Brain Research. Molecular Brain Research. 43: 105-16. PMID 9037524 DOI: 10.1016/S0169-328X(96)00162-3 |
0.387 |
|
| 1996 |
Chapman AG, Woodburn VL, Woodruff GN, Meldrum BS. Anticonvulsant effect of reduced NMDA receptor expression in audiogenic DBA/2 mice. Epilepsy Research. 26: 25-35. PMID 8985683 DOI: 10.1016/S0920-1211(96)00036-8 |
0.361 |
|
| 1996 |
Smith SE, Man CM, Yip PK, Tang E, Chapman AG, Meldrum BS. Anticonvulsant effects of 7-nitroindazole in rodents with reflex epilepsy may result from L-arginine accumulation or a reduction in nitric oxide or L-citrulline formation. British Journal of Pharmacology. 119: 165-73. PMID 8872370 DOI: 10.1111/j.1476-5381.1996.tb15690.x |
0.378 |
|
| 1995 |
Meldrum BS. Neurotransmission in epilepsy. Epilepsia. 36: S30-5. PMID 23057108 |
0.314 |
|
| 1995 |
Chapman AG, Dürmüller N, Harrison BL, Baron BM, Parvez N, Meldrum BS. Anticonvulsant activity of a novel NMDA/glycine site antagonist, MDL 104,653, against kindled and sound-induced seizures. European Journal of Pharmacology. 274: 83-8. PMID 7768284 DOI: 10.1016/0014-2999(94)00713-H |
0.369 |
|
| 1995 |
Smith SE, Parvez NS, Chapman AG, Meldrum BS. The gamma-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy. European Journal of Pharmacology. 273: 259-65. PMID 7737333 DOI: 10.1016/0014-2999(94)00696-5 |
0.383 |
|
| 1995 |
Meldrum BS. Excitatory amino acid receptors and their role in epilepsy and cerebral ischemia. Annals of the New York Academy of Sciences. 757: 492-505. PMID 7611707 DOI: 10.1111/j.1749-6632.1995.tb17509.x |
0.311 |
|
| 1994 |
Dürmüller N, Craggs M, Meldrum BS. The effect of the non-NMDA receptor antagonist GYKI 52466 and NBQX and the competitive NMDA receptor antagonist D-CPPene on the development of amygdala kindling and on amygdala-kindled seizures. Epilepsy Research. 17: 167-74. PMID 8194512 DOI: 10.1016/0920-1211(94)90016-7 |
0.362 |
|
| 1994 |
Meldrum BS. The role of glutamate in epilepsy and other CNS disorders. Neurology. 44: S14-23. PMID 7970002 |
0.39 |
|
| 1994 |
Pearce PC, Maclean CJ, Shergill HK, Ward EM, Halsey MJ, Tindley G, Pearson J, Meldrum BS. Protection from high pressure induced hyperexcitability by the AMPA/kainate receptor antagonists GYKI 52466 and LY 293558. Neuropharmacology. 33: 605-12. PMID 7936094 DOI: 10.1016/0028-3908(94)90164-3 |
0.306 |
|
| 1994 |
Arvin B, Lekieffre D, Graham JL, Moncada C, Chapman AG, Meldrum BS. Effect of the non-NMDA receptor antagonist GYKI 52466 on the microdialysate and tissue concentrations of amino acids following transient forebrain ischaemia. Journal of Neurochemistry. 62: 1458-67. PMID 7907651 DOI: 10.1046/J.1471-4159.1994.62041458.X |
0.395 |
|
| 1993 |
Chapman AG, al-Zubaidy Z, Meldrum BS. Aniracetam reverses the anticonvulsant action of NBQX and GYKI 52466 in DBA/2 mice. European Journal of Pharmacology. 231: 301-3. PMID 8453982 DOI: 10.1016/0014-2999(93)90465-T |
0.311 |
|
| 1993 |
Chapman AG, Meldrum BS. Excitatory amino acid antagonists and epilepsy. Biochemical Society Transactions. 21: 106-10. PMID 8449271 |
0.312 |
|
| 1993 |
Smith SE, al-Zubaidy ZA, Chapman AG, Meldrum BS. Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. Epilepsy Research. 15: 101-11. PMID 8103738 DOI: 10.1016/0920-1211(93)90091-K |
0.313 |
|
| 1993 |
Meldrum BS. Intracerebral microdialysis and seizure initiation. Lancet. 341: 1627. PMID 8099996 DOI: 10.1016/0140-6736(93)90764-8 |
0.328 |
|
| 1993 |
Millan MH, Chapman AG, Meldrum BS. Extracellular amino acid levels in hippocampus during pilocarpine-induced seizures. Epilepsy Research. 14: 139-48. PMID 8095893 DOI: 10.1016/0920-1211(93)90018-3 |
0.369 |
|
| 1993 |
Meldrum BS. Neurotransmitters and Epilepsy Journal of Clinical Neurophysiology. 10: 116. DOI: 10.1097/00004691-199301000-00014 |
0.327 |
|
| 1992 |
Meldrum BS, Swan JH, Leach MJ, Millan MH, Gwinn R, Kadota K, Graham SH, Chen J, Simon RP. Reduction of glutamate release and protection against ischemic brain damage by BW 1003C87. Brain Research. 593: 1-6. PMID 1458310 DOI: 10.1016/0006-8993(92)91254-C |
0.383 |
|
| 1992 |
White HS, Patel S, Meldrum BS. Anticonvulsant profile of MDL 27,266: an orally active, broad-spectrum anticonvulsant agent. Epilepsy Research. 12: 217-26. PMID 1396547 DOI: 10.1016/0920-1211(92)90076-6 |
0.37 |
|
| 1992 |
De Sarro G, Meldrum BS, De Sarro A, Patel S. Excitatory neurotransmitters in the lateral habenula and pedunculopontine nucleus of rat modulate limbic seizures induced by pilocarpine. Brain Research. 591: 209-22. PMID 1359921 DOI: 10.1016/0006-8993(92)91701-F |
0.377 |
|
| 1992 |
Meldrum BS, Craggs MD, Dürmüller N, Smith SE, Chapman AG. The effects of AMPA receptor antagonists on kindled seizures and on reflex epilepsy in rodents and primates. Epilepsy Research. Supplement. 9: 307-11. PMID 1337444 |
0.395 |
|
| 1992 |
Meldrum BS. Excitatory amino acids in epilepsy and potential novel therapies. Epilepsy Research. 12: 189-96. PMID 1327746 DOI: 10.1016/0920-1211(92)90040-Z |
0.323 |
|
| 1991 |
De Sarro G, De Sarro A, Meldrum BS. Anticonvulsant action of 2-chloroadenosine injected focally into the inferior colliculus and substantia nigra. European Journal of Pharmacology. 194: 145-52. PMID 2060598 DOI: 10.1016/0014-2999(91)90098-B |
0.394 |
|
| 1991 |
Millan MH, Wardley-Smith B, Dürmüller N, Meldrum BS. The high pressure neurological syndrome in genetically epilepsy prone rats: protective effect of 2-amino-7-phosphono heptanoate. Experimental Neurology. 112: 317-20. PMID 2029931 DOI: 10.1016/0014-4886(91)90133-W |
0.304 |
|
| 1991 |
Chapman AG, Smith SE, Meldrum BS. The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice. Epilepsy Research. 9: 92-6. PMID 1794356 DOI: 10.1016/0920-1211(91)90018-B |
0.346 |
|
| 1991 |
Millan MH, Obrenovitch TP, Sarna GS, Lok SY, Symon L, Meldrum BS. Changes in rat brain extracellular glutamate concentration during seizures induced by systemic picrotoxin or focal bicuculline injection: an in vivo dialysis study with on-line enzymatic detection. Epilepsy Research. 9: 86-91. PMID 1794355 DOI: 10.1016/0920-1211(91)90017-A |
0.345 |
|
| 1991 |
Meldrum BS. Excitatory amino acid transmitters in epilepsy. Epilepsia. 32: S1-3. PMID 1723042 |
0.364 |
|
| 1991 |
Smith SE, Dürmüller N, Meldrum BS. The non-N-methyl-D-aspartate receptor antagonists, GYKI 52466 and NBQX are anticonvulsant in two animal models of reflex epilepsy. European Journal of Pharmacology. 201: 179-83. PMID 1686756 DOI: 10.1016/0014-2999(91)90342-N |
0.358 |
|
| 1991 |
Chapman AG, Graham JL, Patel S, Meldrum BS. Anticonvulsant activity of two orally active competitive N-methyl-D-aspartate antagonists, CGP 37849 and CGP 39551, against sound-induced seizures in DBA/2 mice and photically induced myoclonus in Papio papio. Epilepsia. 32: 578-87. PMID 1678345 DOI: 10.1111/J.1528-1157.1991.Tb04695.X |
0.42 |
|
| 1990 |
De Sarro G, De Sarro A, Federico F, Meldrum BS. Anticonvulsant properties of some calcium antagonists on sound-induced seizures in genetically epilepsy prone rats. General Pharmacology. 21: 769-78. PMID 2276595 DOI: 10.1016/0306-3623(90)91032-M |
0.311 |
|
| 1990 |
Fine A, Meldrum BS, Patel S. Modulation of experimentally induced epilepsy by intracerebral grafts of fetal GABAergic neurons. Neuropsychologia. 28: 627-34. PMID 2168529 DOI: 10.1016/0028-3932(90)90038-P |
0.337 |
|
| 1990 |
Smith SE, Meldrum BS. Receptor site specificity for the acute effects of beta-N-methylamino-alanine in mice. European Journal of Pharmacology. 187: 131-4. PMID 1980247 DOI: 10.1016/0014-2999(90)90350-F |
0.306 |
|
| 1990 |
Turski L, Stephens DN, Jensen LH, Petersen EN, Meldrum BS, Patel S, Hansen JB, Löscher W, Schneider HH, Schmiechen R. Anticonvulsant action of the beta-carboline abecarnil: studies in rodents and baboon, Papio papio. The Journal of Pharmacology and Experimental Therapeutics. 253: 344-52. PMID 1970362 |
0.36 |
|
| 1989 |
Meldrum BS. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. British Journal of Clinical Pharmacology. 27: 3S-11S. PMID 2667605 |
0.305 |
|
| 1989 |
Faingold CL, Millan MH, Boersma Anderson CA, Meldrum BS. Induction of audiogenic seizures in normal and genetically epilepsy-prone rats following focal microinjection of an excitant amino acid into reticular formation and auditory nuclei. Epilepsy Research. 3: 199-205. PMID 2659321 DOI: 10.1016/0920-1211(89)90024-7 |
0.351 |
|
| 1989 |
Millan MH, Wardley-Smith B, Halsey MJ, Meldrum BS. Studies on the role of the NMDA receptor in the substantia nigra pars reticulata and entopeduncular nucleus in the development of the high pressure neurological syndrome in rats. Experimental Brain Research. 78: 174-8. PMID 2556289 DOI: 10.1007/BF00230696 |
0.311 |
|
| 1989 |
Meldrum B. Epilepsy and the Reticular Formations: The Role of the Reticular Core in Convulsive Seizures. (Neurology and Neurobiology Vol 2.) Journal of Neurology, Neurosurgery & Psychiatry. 52: 1021-1022. DOI: 10.1136/jnnp.52.8.1021-b |
0.315 |
|
| 1988 |
De Sarro GB, Meldrum BS, Nisticó G. Anticonvulsant effects of some calcium entry blockers in DBA/2 mice. British Journal of Pharmacology. 93: 247-56. PMID 3359104 |
0.301 |
|
| 1988 |
Millan MH, Meldrum BS, Boersma CA, Faingold CL. Excitant amino acids and audiogenic seizures in the genetically epilepsy-prone rat. II. Efferent seizure propagating pathway. Experimental Neurology. 99: 687-98. PMID 3342851 DOI: 10.1016/0014-4886(88)90185-9 |
0.385 |
|
| 1988 |
Faingold CL, Millan MH, Boersma CA, Meldrum BS. Excitant amino acids and audiogenic seizures in the genetically epilepsy-prone rat. I. Afferent seizure initiation pathway. Experimental Neurology. 99: 678-86. PMID 3342850 DOI: 10.1016/0014-4886(88)90184-7 |
0.393 |
|
| 1988 |
Patel S, Meldrum BS, Fine A. Susceptibility to pilocarpine-induced seizures in rats increases with age. Behavioural Brain Research. 31: 165-7. PMID 3202947 DOI: 10.1016/0166-4328(88)90019-8 |
0.301 |
|
| 1988 |
Patel S, De Sarro GB, Meldrum BS. Regulation of seizure threshold by excitatory amino acids in the striatum and entopeduncular nucleus of rats. Neuroscience. 27: 837-50. PMID 3075270 DOI: 10.1016/0306-4522(88)90187-X |
0.369 |
|
| 1988 |
Meldrum B, Millan M, Patel S, de Sarro G. Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists. Journal of Neural Transmission. 72: 191-200. PMID 3047315 DOI: 10.1007/BF01243419 |
0.424 |
|
| 1988 |
Millan MH, Patel S, Meldrum BS. The involvement of excitatory amino acid receptors within the prepiriform cortex in pilocarpine-induced limbic seizures in rats. Experimental Brain Research. 72: 517-22. PMID 2853076 DOI: 10.1007/BF00250597 |
0.404 |
|
| 1988 |
Patel S, Millan MH, Meldrum BS. Decrease in excitatory transmission within the lateral habenula and the mediodorsal thalamus protects against limbic seizures in rats. Experimental Neurology. 101: 63-74. PMID 2839355 DOI: 10.1016/0014-4886(88)90065-9 |
0.434 |
|
| 1987 |
Turski L, Meldrum BS, Cavalheiro EA, Calderazzo-Filho LS, Bortolotto ZA, Ikonomidou-Turski C, Turski WA. Paradoxical anticonvulsant activity of the excitatory amino acid N-methyl-D-aspartate in the rat caudate-putamen. Proceedings of the National Academy of Sciences of the United States of America. 84: 1689-93. PMID 3550795 DOI: 10.1073/pnas.84.6.1689 |
0.472 |
|
| 1987 |
Falch E, Meldrum BS, Krogsgaard-Larsen P. GABA uptake inhibitors. Synthesis and effects on audiogenic seizures of ester prodrugs of nipecotic acid, guvacine and cis-4-hydroxynipecotic acid. Drug Design and Delivery. 2: 9-21. PMID 3509345 |
0.304 |
|
| 1987 |
Evans MC, Swan JH, Meldrum BS. An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus. Neuroscience Letters. 83: 287-92. PMID 3441311 DOI: 10.1016/0304-3940(87)90101-7 |
0.325 |
|
| 1987 |
Chapman AG, Meldrum BS, Nanji N, Watkins JC. Anticonvulsant action and biochemical effects in DBA/2 mice of CPP (3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonate), a novel N-methyl-D-aspartate antagonist. European Journal of Pharmacology. 139: 91-6. PMID 3308490 DOI: 10.1016/0014-2999(87)90501-2 |
0.32 |
|
| 1987 |
Chapman AG, De Sarro GB, Premachandra M, Meldrum BS. Bidirectional effects of beta-carbolines in reflex epilepsy. Brain Research Bulletin. 19: 337-46. PMID 3119161 DOI: 10.1016/0361-9230(87)90102-X |
0.321 |
|
| 1987 |
Turski L, Meldrum BS, Turski WA, Watkins JC. Evidence that antagonism at non-NMDA receptors results in anticonvulsant action. European Journal of Pharmacology. 136: 69-73. PMID 3036544 DOI: 10.1016/0014-2999(87)90780-1 |
0.423 |
|
| 1987 |
Patel S, Millan MH, Meldrum BS. Neurotransmission in the pedunculopontine nucleus and pilocarpine-induced motor limbic seizures in rats. Neuroscience Letters. 74: 243-9. PMID 3033555 DOI: 10.1016/0304-3940(87)90157-1 |
0.359 |
|
| 1987 |
Meldrum BS, Swan JH, Ottersen OP, Storm-Mathisen J. Redistribution of transmitter amino acids in rat hippocampus and cerebellum during seizures induced by L-allylglycine and bicuculline: an immunocytochemical study with antisera against conjugated GABA, glutamate and aspartate. Neuroscience. 22: 17-27. PMID 2888043 DOI: 10.1016/0306-4522(87)90194-1 |
0.327 |
|
| 1987 |
Meldrum B. Biorhythms and Epilepsy Neurochemistry International. 10: 128. DOI: 10.1016/0197-0186(87)90186-0 |
0.308 |
|
| 1986 |
Chapman AG, Faingold CL, Hart GP, Bowker HM, Meldrum BS. Brain regional amino acid levels in seizure susceptible rats: Changes related to sound-induced seizures. Neurochemistry International. 8: 273-9. PMID 20493057 DOI: 10.1016/0197-0186(86)90174-9 |
0.396 |
|
| 1986 |
Meldrum BS, Turski L, Schwarz M, Czuczwar SJ, Sontag KH. Anticonvulsant action of 1,3-dimethyl-5-aminoadamantane. Pharmacological studies in rodents and baboon, Papio papio. Naunyn-Schmiedeberg's Archives of Pharmacology. 332: 93-7. PMID 3951570 DOI: 10.1007/Bf00633204 |
0.4 |
|
| 1986 |
De Sarro G, Patel S, Meldrum BS. Anticonvulsant action of a kainate antagonist gamma-D-glutamyl aminomethylsulphonic acid injected focally into the substantia nigra and entopeduncular nucleus. European Journal of Pharmacology. 132: 229-36. PMID 3816977 DOI: 10.1016/0014-2999(86)90609-6 |
0.399 |
|
| 1986 |
Millan MH, Patel S, Meldrum BS. Olfactory bulbectomy protects against pilocarpine-induced motor limbic seizures in rats. Brain Research. 398: 204-6. PMID 3801895 DOI: 10.1016/0006-8993(86)91271-0 |
0.35 |
|
| 1986 |
Millan MH, Patel S, Mello LM, Meldrum BS. Focal injection of 2-amino-7-phosphonoheptanoic acid into prepiriform cortex protects against pilocarpine-induced limbic seizures in rats. Neuroscience Letters. 70: 69-74. PMID 3774222 DOI: 10.1016/0304-3940(86)90439-8 |
0.363 |
|
| 1986 |
Millan MH, Meldrum BS, Faingold CL. Induction of audiogenic seizure susceptibility by focal infusion of excitant amino acid or bicuculline into the inferior colliculus of normal rats. Experimental Neurology. 91: 634-9. PMID 3512285 DOI: 10.1016/0014-4886(86)90059-2 |
0.395 |
|
| 1986 |
De Sarro GB, Nistico G, Meldrum BS. Anticonvulsant properties of flunarizine on reflex and generalized models of epilepsy. Neuropharmacology. 25: 695-701. PMID 3092126 DOI: 10.1016/0028-3908(86)90084-5 |
0.38 |
|
| 1986 |
Meldrum BS. Neuropathological consequences of chemically and electrically induced seizures. Annals of the New York Academy of Sciences. 462: 186-93. PMID 3085568 |
0.305 |
|
| 1986 |
Simon RP, Schmidley JW, Meldrum BS, Swan JH, Chapman AG. Excitotoxic mechanisms in hypoglycaemic hippocampal injury. Neuropathology and Applied Neurobiology. 12: 567-76. PMID 3031525 DOI: 10.1111/J.1365-2990.1986.Tb00160.X |
0.362 |
|
| 1986 |
Turski L, Cavalheiro EA, Turski WA, Meldrum BS. Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate. Neuroscience. 18: 61-77. PMID 3016600 DOI: 10.1016/0306-4522(86)90179-X |
0.486 |
|
| 1986 |
Patel S, Millan MH, Mello LM, Meldrum BS. 2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats. Neuroscience Letters. 64: 226-30. PMID 3008043 DOI: 10.1016/0304-3940(86)90105-9 |
0.424 |
|
| 1985 |
Chapman AG, Hart GP, Meldrum BS, Turski L, Watkins JC. Anticonvulsant activity of two novel piperazine derivatives with potent kainate antagonist activity. Neuroscience Letters. 55: 325-30. PMID 3892372 DOI: 10.1016/0304-3940(85)90456-2 |
0.337 |
|
| 1985 |
Turski L, Meldrum BS, Jones AW, Watkins JC. Anticonvulsant action of stereoisomers of gamma-glutamylaminomethylsulphonic acid in mice. European Journal of Pharmacology. 111: 279-83. PMID 2990954 DOI: 10.1016/0014-2999(85)90769-1 |
0.342 |
|
| 1985 |
Turski L, Meldrum BS, Collins JF. Anticonvulsant action of beta-kainic acid in mice. Is beta-kainic acid an N-methyl-D-aspartate antagonist? Brain Research. 336: 162-6. PMID 2860949 DOI: 10.1016/0006-8993(85)90429-9 |
0.396 |
|
| 1985 |
Rostain JC, Wardley-Smith B, Meldrum BS. Effects of 2-amino-7-phosphonoheptanoic acid on EEG of rats. Electroencephalography and Clinical Neurophysiology. 60: 367-9. PMID 2579803 DOI: 10.1016/0013-4694(85)90010-0 |
0.333 |
|
| 1984 |
Croucher MJ, Meldrum BS, Collins JF. Anticonvulsant and proconvulsant properties of a series of structural isomers of piperidine dicarboxylic acid. Neuropharmacology. 23: 467-72. PMID 6728132 DOI: 10.1016/0028-3908(84)90257-0 |
0.391 |
|
| 1984 |
Evans MC, Meldrum BS. Regional brain glucose metabolism in chemically-induced seizures in the rat. Brain Research. 297: 235-45. PMID 6722542 DOI: 10.1016/0006-8993(84)90565-1 |
0.402 |
|
| 1984 |
Chapman AG, Croucher MJ, Meldrum BS. Evaluation of anticonvulsant drugs in DBA/2 mice with sound-induced seizures. Arzneimittel-Forschung. 34: 1261-4. PMID 6542784 |
0.346 |
|
| 1984 |
De Sarro G, Meldrum BS, Reavill C. Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid in the substantia nigra. European Journal of Pharmacology. 106: 175-9. PMID 6529964 DOI: 10.1016/0014-2999(84)90692-7 |
0.316 |
|
| 1984 |
Croucher M, De Sarro G, Jensen L, Meldrum B. Behavioural and convulsant actions of two methyl esters of β-carboline- 3-carboxylic acid in photosensitive baboons and in DBA/2 mice European Journal of Pharmacology. 104: 55-60. PMID 6499918 DOI: 10.1016/0014-2999(84)90368-6 |
0.313 |
|
| 1984 |
Evans MC, Griffiths T, Meldrum BS. Kainic acid seizures and the reversibility of calcium loading in vulnerable neurons in the hippocampus. Neuropathology and Applied Neurobiology. 10: 285-302. PMID 6483108 DOI: 10.1111/J.1365-2990.1984.Tb00360.X |
0.455 |
|
| 1984 |
Griffiths T, Evans MC, Meldrum BS. Status epilepticus: the reversibility of calcium loading and acute neuronal pathological changes in the rat hippocampus. Neuroscience. 12: 557-67. PMID 6462462 DOI: 10.1016/0306-4522(84)90073-3 |
0.398 |
|
| 1984 |
Chapman AG, Croucher MJ, Meldrum BS. Anticonvulsant activity of intracerebroventricularly administered valproate and valproate analogues. A dose-dependent correlation with changes in brain aspartate and GABA levels in DBA/2 mice. Biochemical Pharmacology. 33: 1459-63. PMID 6428419 DOI: 10.1016/0006-2952(84)90413-1 |
0.387 |
|
| 1984 |
De Sarro GB, Croucher MJ, Meldrum BS. Anticonvulsant actions of DS 103-282. Pharmacological studies in rodents and the baboon, Papio papio. Neuropharmacology. 23: 525-30. PMID 6377114 DOI: 10.1016/0028-3908(84)90025-X |
0.38 |
|
| 1984 |
Jones AW, Croucher MJ, Meldrum BS, Watkins JC. Suppression of audiogenic seizures in DBA/2 mice by two new dipeptide NMDA receptor antagonists. Neuroscience Letters. 45: 157-61. PMID 6145126 DOI: 10.1016/0304-3940(84)90092-2 |
0.441 |
|
| 1984 |
Chapman AG, Westerberg E, Premachandra M, Meldrum BS. Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid. Journal of Neurochemistry. 43: 62-70. PMID 6144732 |
0.33 |
|
| 1984 |
Croucher MJ, Meldrum BS, Jones AW, Watkins JC. gamma-D-Glutamylaminomethylsulphonic acid (GAMS), a kainate and quisqualate antagonist, prevents sound-induced seizures in DBA/2 mice. Brain Research. 322: 111-4. PMID 6097331 DOI: 10.1016/0006-8993(84)91186-7 |
0.483 |
|
| 1984 |
Meldrum B. Proconvulsant and anticonvulsant actions in photosensitive baboons of β-carboline derivatives Neuropharmacology. 23: 845-846. DOI: 10.1016/0028-3908(84)90276-4 |
0.336 |
|
| 1983 |
Chapman AG, Collins JF, Meldrum BS, Westerberg E. Uptake of a novel anticonvulsant compound, 2-amino-7-phosphono-[4,5-3H]heptanoic acid, into mouse brain. Neuroscience Letters. 37: 75-80. PMID 6877661 DOI: 10.1016/0304-3940(83)90507-4 |
0.329 |
|
| 1983 |
Croucher MJ, Meldrum BS, Krogsgaard-Larsen P. Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration. European Journal of Pharmacology. 89: 217-28. PMID 6873158 DOI: 10.1016/0014-2999(83)90497-1 |
0.463 |
|
| 1983 |
Evans M, Griffiths T, Meldrum B. Early changes in the rat hippocampus following seizures induced by bicuculline or L-allylglycine: a light and electron microscope study. Neuropathology and Applied Neurobiology. 9: 39-52. PMID 6843775 DOI: 10.1111/j.1365-2990.1983.tb00322.x |
0.416 |
|
| 1983 |
Westerberg E, Chapman AG, Meldrum BS. Effect of 2-amino-7-phosphonoheptanoic acid on regional brain amino acid levels in fed and fasted rodents. Journal of Neurochemistry. 41: 1755-60. PMID 6644309 DOI: 10.1111/J.1471-4159.1983.Tb00890.X |
0.387 |
|
| 1983 |
Griffiths T, Evans MC, Meldrum BS. Intracellular calcium accumulation in rat hippocampus during seizures induced by bicuculline or L-allylglycine. Neuroscience. 10: 385-95. PMID 6633867 DOI: 10.1016/0306-4522(83)90141-0 |
0.321 |
|
| 1983 |
Meldrum BS, Croucher MJ, Badman G, Collins JF. Antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon, Papio papio. Neuroscience Letters. 39: 101-4. PMID 6138738 DOI: 10.1016/0304-3940(83)90172-6 |
0.405 |
|
| 1983 |
Meldrum BS, Croucher MJ, Czuczwar SJ, Collins JF, Curry K, Joseph M, Stone TW. A comparison of the anticonvulsant potency of (+/-) 2-amino-5-phosphonopentanoic acid and (+/-) 2-amino-7-phosphonoheptanoic acid. Neuroscience. 9: 925-30. PMID 6137790 DOI: 10.1016/0306-4522(83)90281-6 |
0.396 |
|
| 1982 |
Croucher MJ, Collins JF, Meldrum BS. Anticonvulsant action of excitatory amino acid antagonists. Science (New York, N.Y.). 216: 899-901. PMID 7079744 |
0.362 |
|
| 1982 |
Meldrum BS, Anlezark GM, Adam HK, Greenwood DT. Anticonvulsant and proconvulsant properties of viloxazine hydrochloride: pharmacological and pharmacokinetic studies in rodents and the epileptic baboon. Psychopharmacology. 76: 212-7. PMID 6808538 DOI: 10.1007/BF00432547 |
0.33 |
|
| 1982 |
Meldrum BS, Croucher MJ. Anticonvulsant action of clobazam and desmethylclobazam in reflex epilepsy in rodents and baboons Drug Development Research. 2: 33-38. DOI: 10.1002/DDR.430010707 |
0.433 |
|
| 1980 |
Ben-Ari Y, Tremblay E, Ottersen OP, Meldrum BS. The role of epileptic activity in hippocampal and "remote" cerebral lesions induced by kainic acid. Brain Research. 191: 79-97. PMID 7378761 DOI: 10.1016/0006-8993(80)90316-9 |
0.305 |
|
| 1980 |
Horton RW, Meldrum BS, Pedley TA, McWilliam JR. Regional cerebral blood flow in the rat during prolonged seizure activity. Brain Research. 192: 399-412. PMID 6769547 DOI: 10.1016/0006-8993(80)90892-6 |
0.338 |
|
| 1980 |
Meldrum B, Horton R. Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy. European Journal of Pharmacology. 61: 231-7. PMID 6767614 DOI: 10.1016/0014-2999(80)90125-9 |
0.367 |
|
| 1980 |
Menini C, Meldrum BS, Riche D, Silva-Comte C, Stutzmann JM. Sustained limbic seizures induced by intraamygdaloid kainic acid in the baboon: Symptomatology and neuropathological consequences. Annals of Neurology. 8: 501-9. PMID 6254439 DOI: 10.1002/ana.410080507 |
0.368 |
|
| 1979 |
Meldrum B. Physiological changes during prolonged seizures and epileptic brain damage. Neuropadiatrie. 9: 203-12. PMID 581396 DOI: 10.1055/S-0028-1091481 |
0.354 |
|
| 1979 |
Horton RW, Collins JF, Anlezark GM, Meldrum BS. Convulsant and anticonvulsant actions in DBA/2 mice of compounds blocking the reuptake of GABA. European Journal of Pharmacology. 59: 75-83. PMID 510401 DOI: 10.1016/0014-2999(79)90026-8 |
0.343 |
|
| 1978 |
Anlezark GM, Horton RW, Meldrum BS. Dopamine agonists and audiogenic seizures: the relationship between protection against seizures and changes in monoamine metabolism. Biochemical Pharmacology. 27: 2821-8. PMID 581645 DOI: 10.1016/0006-2952(78)90196-X |
0.311 |
|
| 1978 |
Chapman AG, Horton RW, Meldrum BS. Anticonvulsant action of a 1,5-benzodiazepine, clobazam, in reflex epilepsy. Epilepsia. 19: 293-9. PMID 98317 |
0.359 |
|
| 1977 |
Trimble M, Anlezark G, Meldrum B. Seizure activity in photosensitive baboons following antidepressant drugs and the role of serotoninergic mechanisms. Psychopharmacology. 51: 159-64. PMID 402667 DOI: 10.1007/BF00431733 |
0.348 |
|
| 1977 |
Chapman AG, Meldrum BS, Siesjö BK. Cerebral metabolic changes during prolonged epileptic seizures in rats. Journal of Neurochemistry. 28: 1025-35. PMID 16986 |
0.315 |
|
| 1976 |
Anlezark G, Horton RW, Meldrum BS, Christina M, Sawaya B. Anticonvulsant action of ethanolamine-O-sulphate and di-n-propylacetate and the metabolism of γ-aminobutyric acid (GABA) in mice with audiogenic seizures Biochemical Pharmacology. 25: 413-417. PMID 779794 DOI: 10.1016/0006-2952(76)90343-9 |
0.415 |
|
| 1975 |
Meldrum B, Anlezark G, Trimble M. Drugs modifying dopaminergic activity and behaviour, the EEG and epilepsy in Papio papio. European Journal of Pharmacology. 32: 203-13. PMID 1149807 DOI: 10.1016/0014-2999(75)90284-8 |
0.358 |
|
| 1975 |
Meldrum BS, Stephenson JD. Enhancement of picrotoxin convulsions in chicks and mice by the prior intraperitoneal injection of hypertonic GABA or mannitol. European Journal of Pharmacology. 30: 368-71. PMID 1126369 DOI: 10.1016/0014-2999(75)90124-7 |
0.324 |
|
| 1975 |
Meldrum BS, BChir, Horton RW, Toseland PA. A primate model for testing anticonvulsant drugs. Archives of Neurology. 32: 289-94. PMID 237498 DOI: 10.1001/archneur.1975.00490470033003 |
0.347 |
|
| 1973 |
Meldrum BS, Horton RW. Physiology of status epilepticus in primates. Archives of Neurology. 28: 1-9. PMID 4629380 DOI: 10.1001/Archneur.1973.00490190019001 |
0.389 |
|
| 1973 |
Meldrum BS, Brierley JB. Prolonged epileptic seizures in primates. Ischemic cell change and its relation to ictal physiological events. Archives of Neurology. 28: 10-7. PMID 4629379 DOI: 10.1001/Archneur.1973.00490190028002 |
0.421 |
|
| 1973 |
Horton RW, Meldrum BS. Seizures induced by allylglycine, 3-mercaptopropionic acid and 4-deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase. British Journal of Pharmacology. 49: 52-63. PMID 4207045 |
0.417 |
|
| 1972 |
Brierley JB, Horton RW, Meldrum BS. Physiological observations during prolonged epileptic seizures in primates and their relation to subsequent brain damage. The Journal of Physiology. 222: 69P-70P. PMID 5037105 |
0.308 |
|
| 1971 |
Meldrum BS, Naquet R. Effects of psilocybin, dimethyltryptamine, mescaline and various lysergic acid derivatives on the EEG and on photically induced epilepsy in the baboon (Papio papio). Electroencephalography and Clinical Neurophysiology. 31: 563-72. PMID 4111479 DOI: 10.1016/0013-4694(71)90072-1 |
0.323 |
|
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