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Kristi A. Leonard, Ph.D. - Publications

Affiliations: 
2000 State University of New York, Buffalo, Buffalo, NY, United States 
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14 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Gege C, Albers M, Kinzel O, Kleymann G, Schlüter T, Steeneck C, Hoffmann T, Xue X, Cummings MD, Spurlino J, Milligan C, Fourie AM, Edwards JP, Leonard K, Coe K, et al. Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt. Bioorganic & Medicinal Chemistry Letters. 30: 127205. PMID 32336498 DOI: 10.1016/J.Bmcl.2020.127205  0.359
2020 Steeneck C, Gege C, Kinzel O, Albers M, Kleymann G, Schlüter T, Schulz A, Xue X, Cummings MD, Fourie AM, Leonard KA, Scott B, Edwards JP, Hoffmann T, Goldberg SD. Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach. Bioorganic & Medicinal Chemistry Letters. 30: 127174. PMID 32334912 DOI: 10.1016/J.Bmcl.2020.127174  0.33
2019 Tanis VM, Venkatesan H, Cummings MD, Albers M, Kent Barbay J, Herman K, Kummer DA, Milligan C, Nelen MI, Nishimura R, Schlueter T, Scott B, Spurlino J, Wolin R, Woods C, ... ... Leonard K, et al. 3-Substituted Quinolines as RORγt Inverse Agonists. Bioorganic & Medicinal Chemistry Letters. PMID 31010722 DOI: 10.1016/J.Bmcl.2019.04.021  0.319
2018 Gege C, Cummings MD, Albers M, Kinzel O, Kleymann G, Schlüter T, Steeneck C, Nelen MI, Milligan C, Spurlino J, Xue X, Leonard K, Edwards JP, Fourie A, Goldberg SD, et al. Identification and biological evaluation of thiazole-based inverse agonists of RORγt. Bioorganic & Medicinal Chemistry Letters. PMID 29631962 DOI: 10.1016/J.Bmcl.2018.03.093  0.335
2017 Barbay JK, Cummings MD, Abad M, Castro G, Kreutter KD, Kummer DA, Maharoof U, Milligan C, Nishimura R, Pierce J, Schalk-Hihi C, Spurlino J, Tanis VM, Urbanski M, Venkatesan H, ... ... Leonard K, et al. 6-Substituted quinolines as RORγt inverse agonists. Bioorganic & Medicinal Chemistry Letters. PMID 29079472 DOI: 10.1016/J.Bmcl.2017.10.027  0.337
2013 Shook BC, Chakravarty D, Barbay JK, Wang A, Leonard K, Alford V, Powell MT, Rassnick S, Scannevin RH, Carroll K, Wallace N, Crooke J, Ault M, Lampron L, Westover L, et al. Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 23: 2688-91. PMID 23522563 DOI: 10.1016/J.Bmcl.2013.02.078  0.328
2012 Subasinghe NL, Khalil E, Travins JM, Ali F, Ballentine SK, Hufnagel HR, Pan W, Leonard K, Bone RF, Soll RM, Crysler CS, Ninan N, Kirkpatrick J, Kolpak MX, Diloreto KA, et al. Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s. Bioorganic & Medicinal Chemistry Letters. 22: 5303-7. PMID 22795627 DOI: 10.1016/J.Bmcl.2012.06.030  0.317
2012 Shook BC, Rassnick S, Wallace N, Crooke J, Ault M, Chakravarty D, Barbay JK, Wang A, Powell MT, Leonard K, Alford V, Scannevin RH, Carroll K, Lampron L, Westover L, et al. Design and characterization of optimized adenosine Aâ‚‚A/A₁ receptor antagonists for the treatment of Parkinson's disease. Journal of Medicinal Chemistry. 55: 1402-17. PMID 22239465 DOI: 10.1021/Jm201640M  0.318
2006 Raboisson P, Manthey CL, Chaikin M, Lattanze J, Crysler C, Leonard K, Pan W, Tomczuk BE, Marugán JJ. Novel potent and selective αvβ3αvβ5 integrin dual antagonists with reduced binding affinity for human serum albumin European Journal of Medicinal Chemistry. 41: 847-861. PMID 16697080 DOI: 10.1016/J.Ejmech.2006.03.008  0.349
2000 Leonard KA, Hall JP, Nelen MI, Davies SR, Gollnick SO, Camacho S, Oseroff AR, Gibson SL, Hilf R, Detty MR. A selenopyrylium photosensitizer for photodynamic therapy related in structure to the antitumor agent AA1 with potent in vivo activity and no long-term skin photosensitization. Journal of Medicinal Chemistry. 43: 4488-98. PMID 11087573 DOI: 10.1021/Jm000154P  0.517
1999 Leonard KA, Nelen MI, Simard TP, Davies SR, Gollnick SO, Oseroff AR, Gibson SL, Hilf R, Chen LB, Detty MR. Synthesis and evaluation of chalcogenopyrylium dyes as potential sensitizers for the photodynamic therapy of cancer. Journal of Medicinal Chemistry. 42: 3953-64. PMID 10508443 DOI: 10.1021/Jm990245Q  0.521
1999 Leonard KA, Nelen MI, Anderson LT, Gibson SL, Hilf R, Detty MR. 2,4,6-triarylchalcogenopyrylium dyes related in structure to the antitumor agent AA1 as in vitro sensitizers for the photodynamic therapy of cancer. Journal of Medicinal Chemistry. 42: 3942-52. PMID 10508442 DOI: 10.1021/Jm990134R  0.525
1999 Leonard K, Nelen M, Raghu M, Detty MR. Chalcogenopyranones from disodium chalcogenide additions to 1,4- pentadiyn-3-ones. The role of enol ethers as intermediates Journal of Heterocyclic Chemistry. 36: 707-717. DOI: 10.1002/Jhet.5570360322  0.413
1996 Leonard KA, Zhou F, Detty MR. Chalcogen(IV)-chalcogen(II) redox cycles. 1. Halogenation of organic substrates with dihaloselenium(IV) and -tellurium(IV) derivatives. Dehalogenation of vicinal dibromides with diaryl tellurides Organometallics. 15: 4285-4292. DOI: 10.1021/Om960476K  0.462
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