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Rebecca J. Howard, Ph.D. - Publications

Affiliations: 
2007 Chemistry and Chemical Biology University of California, San Francisco, San Francisco, CA 
Area:
Channel Physiology
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59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Bergh C, Rovšnik U, Howard R, Lindahl E. Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM. Elife. 12. PMID 38289224 DOI: 10.7554/eLife.86016  0.388
2023 Cowgill J, Fan C, Haloi N, Tobiasson V, Zhuang Y, Howard RJ, Lindahl E. Structure and dynamics of differential ligand binding in the human ρ-type GABA receptor. Neuron. PMID 37659407 DOI: 10.1016/j.neuron.2023.08.006  0.32
2023 Bondarenko V, Chen Q, Singewald K, Haloi N, Tillman TS, Howard RJ, Lindahl E, Xu Y, Tang P. Structural Elucidation of Ivermectin Binding to α7nAChR and the Induced Channel Desensitization. Acs Chemical Neuroscience. PMID 36821490 DOI: 10.1021/acschemneuro.2c00783  0.371
2022 Choudhury K, Howard RJ, Delemotte L. An α-π transition in S6 shapes the conformational cycle of the bacterial sodium channel NavAb. The Journal of General Physiology. 155. PMID 36515966 DOI: 10.1085/jgp.202213214  0.364
2022 Lycksell M, Rovšnik U, Hanke A, Martel A, Howard RJ, Lindahl E. Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel. Proceedings of the National Academy of Sciences of the United States of America. 119: e2210669119. PMID 36480474 DOI: 10.1073/pnas.2210669119  0.34
2022 Zhuang Y, Noviello CM, Hibbs RE, Howard RJ, Lindahl E. Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators. Proceedings of the National Academy of Sciences of the United States of America. 119: e2208081119. PMID 36251999 DOI: 10.1073/pnas.2208081119  0.322
2022 Zhu S, Sridhar A, Teng J, Howard RJ, Lindahl E, Hibbs RE. Structural and dynamic mechanisms of GABA receptor modulators with opposing activities. Nature Communications. 13: 4582. PMID 35933426 DOI: 10.1038/s41467-022-32212-4  0.308
2021 Choudhury K, Kasimova MA, McComas S, Howard RJ, Delemotte L. An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine. Biophysical Journal. PMID 34890580 DOI: 10.1016/j.bpj.2021.12.010  0.404
2021 Bergh C, Heusser SA, Howard R, Lindahl E. Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel. Elife. 10. PMID 34652272 DOI: 10.7554/eLife.68369  0.393
2021 Lycksell M, Rovšnik U, Bergh C, Johansen NT, Martel A, Porcar L, Arleth L, Howard RJ, Lindahl E. Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34504004 DOI: 10.1073/pnas.2108006118  0.406
2021 Howard RJ. Elephants in the dark: insights and incongruities in pentameric ligand-gated ion channel models. Journal of Molecular Biology. 167128. PMID 34224751 DOI: 10.1016/j.jmb.2021.167128  0.477
2021 Rovšnik U, Zhuang Y, Forsberg BO, Carroni M, Yvonnesdotter L, Howard RJ, Lindahl E. Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations. Life Science Alliance. 4. PMID 34210687 DOI: 10.26508/lsa.202101011  0.426
2021 Sridhar A, Lummis SCR, Pasini D, Mehregan A, Brams M, Kambara K, Bertrand D, Lindahl E, Howard RJ, Ulens C. Regulation of a pentameric ligand-gated ion channel by a semi-conserved cationic-lipid binding site. The Journal of Biological Chemistry. 100899. PMID 34157288 DOI: 10.1016/j.jbc.2021.100899  0.374
2021 Carnevale V, Delemotte L, Howard RJ. Molecular Dynamics Simulations of Ion Channels. Trends in Biochemical Sciences. PMID 33941431 DOI: 10.1016/j.tibs.2021.04.005  0.325
2020 Forsberg BO, Aibara S, Howard RJ, Mortezaei N, Lindahl E. Arrangement and symmetry of the fungal E3BP-containing core of the pyruvate dehydrogenase complex. Nature Communications. 11: 4667. PMID 32938938 DOI: 10.1038/S41467-020-18401-Z  0.34
2020 Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh RM, Lindahl E, Hibbs RE. Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature. PMID 32879488 DOI: 10.1038/S41586-020-2654-5  0.362
2020 Hu H, Howard RJ, Bastolla U, Lindahl E, Delarue M. Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel. Proceedings of the National Academy of Sciences of the United States of America. PMID 32482881 DOI: 10.1073/Pnas.1922701117  0.428
2020 Howard RJ, Zhuang Y, Heusser SA, Bergh CC, Rovsnik U, Orellana L, Lindahl E. Allosteric Gating Determinants in the Transmembrane Domain of Pentameric Ligand-Gated Ion Channels Biophysical Journal. 118: 584a. DOI: 10.1016/J.Bpj.2019.11.3169  0.533
2020 Zhuang Y, Gharpure A, Hibbs RE, Howard RJ, Lindahl ER. Molecular Dynamics Simulation of Ligand Binding and Ion Permeation in a Ganglionic Nicotinic Receptor Biophysical Journal. 118: 584a. DOI: 10.1016/J.Bpj.2019.11.3165  0.379
2020 Rovsnik U, Lim V, Blau C, Howard RJ, Lindahl E. Cryo-EM Structure Determination and Model Fitting of the Proton-Gated Ligand-Gated Ion Channel glic at Multiple pH States Biophysical Journal. 118: 581a-582a. DOI: 10.1016/J.Bpj.2019.11.3155  0.492
2020 Bergh C, Orellana L, Heusser SA, Howard RJ, Lindahl E. Mapping pH-Dependent State Transitions of a Pentameric Ligand-gated Ion Channel through Markov State Modeling Biophysical Journal. 118: 191a. DOI: 10.1016/J.Bpj.2019.11.1160  0.416
2019 Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE. Agonist Selectivity and Ion Permeation in the alpha 3 beta 4 Ganglionic Nicotinic Receptor Neuron. 104: 501-511. DOI: 10.2210/Pdb6Pv8/Pdb  0.336
2019 Rovsnik U, Howard R, Forsberg B, Carroni M, Lindahl E. Characterizing Functional States of a Model Ligand-Gated Ion Channel by Cryo-Electron Microscopy Biophysical Journal. 116: 160a. DOI: 10.1016/J.Bpj.2018.11.885  0.476
2019 Lycksell M, Johansen NT, Howard RJ, Arleth L, Lindahl E. Probing Structural States of a Pentameric Ligand-Gated Ion Channel with Small Angle Neutron Scattering Biophysical Journal. 116: 36a-37a. DOI: 10.1016/J.Bpj.2018.11.241  0.366
2019 Delarue MH, Hu H, Howard RJ, Rovsnik U, Hlioui S, Lindahl E. Structural Studies of the Gating Mechanism in a Pentameric Ligand-Gated Ion Channel Containing Two Additional N-Terminal Periplasmic Domains Biophysical Journal. 116: 396a. DOI: 10.1016/J.Bpj.2018.11.2140  0.52
2019 Bergh CC, Orellana L, Howard RJ, Lindahl E. Understanding the Conformational Dynamics of a Pentameric Ligand-Gated Ion Channel through Markov State Modeling Biophysical Journal. 116: 395a-396a. DOI: 10.1016/J.Bpj.2018.11.2138  0.494
2019 Howard RJ, Zhuang Y, Nakamura S, Lycksell M, Kiik H, Rovšnik U, Bergh C, Heusser SA, Orellana L, Lindahl E. Allosteric Modulation via Transmembrane Interfaces in a Pentameric Ligand-Gated Ion Channel Biophysical Journal. 116: 245a-246a. DOI: 10.1016/J.Bpj.2018.11.1344  0.529
2018 Heusser SA, Lycksell M, Wang X, McComas SE, Howard RJ, Lindahl E. Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity. Proceedings of the National Academy of Sciences of the United States of America. PMID 30275330 DOI: 10.1016/J.Bpj.2018.11.2137  0.397
2018 Fourati Z, Howard RJ, Heusser SA, Hu H, Ruza RR, Sauguet L, Lindahl E, Delarue M. Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels. Cell Reports. 23: 993-1004. PMID 29694907 DOI: 10.1016/J.Celrep.2018.03.108  0.563
2018 Howard RJ, Heusser SA, Zhuang Y, Lycksell M, Klement G, Orellana L, Lindahl E. Alcohol Modulation Via Allosteric Transmembrane Sites In Pentameric Ligand-Gated Ion Channels Alcoholism: Clinical and Experimental Research. 42. DOI: 10.1111/Acer.13834  0.533
2018 Heusser SA, Lycksell M, Wang X, Howard RJ, Lindahl E. Flexibility of a Transmembrane Helix Underlies Dramatic Reversal of Net Anesthetic Effects in a Pentameric Ligand-Gated Ion Channel Biophysical Journal. 114: 488a-489a. DOI: 10.1016/J.Bpj.2017.11.2680  0.538
2018 Lycksell M, Heusser SA, Howard RJ, Lindahl E. Expansion of a Transmembrane Cavity Facilitates Anesthetic Potentiation of a Pentameric Ligand Gated Ion Channel Biophysical Journal. 114: 299a. DOI: 10.1016/J.Bpj.2017.11.1707  0.524
2018 Howard RJ, Fourati Z, Heusser SA, Hu H, Ruza RR, Sauguet L, Lindahl E, Delarue M. Structural Details of an Allosteric Mechanism for Bimodal Anesthetic Modulation of Pentameric Ligand-Gated Ion Channels Biophysical Journal. 114: 204a. DOI: 10.1016/J.Bpj.2017.11.1137  0.543
2017 Howard RJ, Carnevale V, Delemotte L, Hellmich UA, Rothberg BS. Permeating disciplines: Overcoming barriers between molecular simulations and classical structure-function approaches in biological ion transport. Biochimica Et Biophysica Acta. PMID 29258839 DOI: 10.1016/J.Bbamem.2017.12.013  0.373
2017 Heusser SA, Howard RJ, Fourati Z, Delarue M, Lindahl E. Structural and Functional Evidence for Multi-Site Allostery Mediated by General Anesthetics in a Model Ligand-Gated Ion Channel Biophysical Journal. 112: 554a. DOI: 10.1016/J.Bpj.2016.11.2990  0.481
2017 Howard RJ, Heusser SA, Yoluk Ö, Snow O, Klement G, Mola AR, MD Ruel T, Lindahl E. Transmembrane Structural Determinants of Alcohol Binding and Modulation in a Model Ligand-Gated Ion Channel Biophysical Journal. 112: 554a. DOI: 10.1016/J.Bpj.2016.11.2988  0.551
2016 Heusser SA, Yoluk Ö, Klement G, Riederer EA, Lindahl E, Howard RJ. Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel. Journal of Neurochemistry. PMID 27102368 DOI: 10.1111/Jnc.13644  0.554
2015 Horani S, Stater EP, Corringer PJ, Trudell JR, Harris RA, Howard RJ. Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors. Alcoholism, Clinical and Experimental Research. 39: 962-8. PMID 25973519 DOI: 10.1111/Acer.12735  0.466
2015 Voigt TB, Heusser S, Klement G, Pouya, I, Mola AR, Ruel TMD, Trudell JR, Lindahl E, Howard RJ. P-54PHYSICOCHEMICAL DETERMINANTS OF ALCOHOL BINDING IN A MODEL LIGAND-GATED ION CHANNEL Alcohol and Alcoholism. 50: i59.1-i59. DOI: 10.1093/Alcalc/Agv080.54  0.561
2015 Yoluk Ö, Heusser S, Pouya I, Howard R, Klement G, Lindahl E. Opening and Selectivity of the Glic Ligand-Gated Ion Channel can be Tuned by Mutation of Hydrophobic Residues in the Pore Biophysical Journal. 108: 431a. DOI: 10.1016/J.Bpj.2014.11.2357  0.51
2014 Howard RJ, Trudell JR, Harris RA. Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics. Pharmacological Reviews. 66: 396-412. PMID 24515646 DOI: 10.1124/Pr.113.007468  0.545
2014 Yoluk O, Riederer EA, Andersson M, Klement G, Trudell JR, Bertaccini EJ, Howard RJ, Lindahl E. Contribution of Structural Elements to Activation and Allosteric Modulation in an Anionic Ligand-Gated Ion Channel Biophysical Journal. 106: 547a. DOI: 10.1016/J.Bpj.2013.11.3046  0.517
2014 Riederer E, Yoluk O, Trudell J, Lindahl E, Harris A, Howard R. Alcohol Modulation of a Eukaryotic Ligand-Gated Ion Channel of Known Structure Biophysical Journal. 106: 545a. DOI: 10.1016/J.Bpj.2013.11.3034  0.466
2014 Klement G, Pouya I, Yoluk Ö, Howard R, Lindahl E. Ligand-Gated Ion Channel Gating Kinetics and the Opening/Closing Mechanism are Sensitive to Mutations Altering the Hydrophobicity of the Ion Conduction Pore Biophysical Journal. 106: 343a. DOI: 10.1016/J.Bpj.2013.11.1958  0.554
2013 Heusser SA, Howard RJ, Borghese CM, Cullins MA, Broemstrup T, Lee US, Lindahl E, Carlsson J, Harris RA. Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels. Molecular Pharmacology. 84: 670-8. PMID 23950219 DOI: 10.1124/Mol.113.087692  0.457
2013 Brömstrup T, Howard RJ, Trudell JR, Harris RA, Lindahl E. Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites. Structure (London, England : 1993). 21: 1307-16. PMID 23891290 DOI: 10.1016/J.Str.2013.06.018  0.447
2013 Sauguet L, Howard RJ, Malherbe L, Lee US, Corringer PJ, Harris RA, Delarue M. Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel. Nature Communications. 4: 1697. PMID 23591864 DOI: 10.1038/Ncomms2682  0.505
2013 Spurny R, Billen B, Howard RJ, Brams M, Debaveye S, Price KL, Weston DA, Strelkov SV, Tytgat J, Bertrand S, Bertrand D, Lummis SC, Ulens C. Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC). The Journal of Biological Chemistry. 288: 8355-64. PMID 23364792 DOI: 10.1074/Jbc.M112.424507  0.557
2013 Howard RJ, Sauguet L, Broemstrup T, Murail S, Lee US, Horani S, Trudell JR, Corringer P, Lindahl E, Delarue M, Harris RA. Alcohol and Anesthetic Binding to Pentameric Ligand-Gated Ion Channels Revealed in a Prokaryotic Model System Biophysical Journal. 104: 635a-636a. DOI: 10.1016/J.Bpj.2012.11.3512  0.529
2013 Sauguet L, Howard R, Malherbe L, Lee US, Corringer P, Harris RA, Delarue M. X-Ray Structures of an Interfacial Potentiating Site for Alcohols and Anesthetics in a Pentameric Ligand-Gated Ion Channel Biophysical Journal. 104: 208a. DOI: 10.1016/J.Bpj.2012.11.1175  0.454
2012 Murail S, Howard RJ, Broemstrup T, Bertaccini EJ, Harris RA, Trudell JR, Lindahl E. Molecular mechanism for the dual alcohol modulation of Cys-loop receptors. Plos Computational Biology. 8: e1002710. PMID 23055913 DOI: 10.1371/Journal.Pcbi.1002710  0.434
2012 Johnson WD, Howard RJ, Trudell JR, Harris RA. The TM2 6' position of GABA(A) receptors mediates alcohol inhibition. The Journal of Pharmacology and Experimental Therapeutics. 340: 445-56. PMID 22072732 DOI: 10.1124/Jpet.111.188037  0.369
2012 Murail S, Howard RJ, Trudell JR, Bertaccini E, Lindahl E. Tracing the Closing of a Ligand-Gated Ion Channel in Atomic Detail: An Unconstrained Four-Microsecond Simulation of GLIC Leads to a Closed State Remarkably Similar to ELIC Biophysical Journal. 102: 113a-114a. DOI: 10.1016/J.Bpj.2011.11.639  0.476
2012 Spurny R, Billen B, Brams M, Howard R, Harris AR, Ulens C. Allosteric Modulators Targeting Multiple Binding Sites in Bacterial Homolog of GABAA Receptor Biophysical Journal. 102: 111a-112a. DOI: 10.1016/J.Bpj.2011.11.628  0.533
2011 Howard RJ, Murail S, Ondricek KE, Corringer PJ, Lindahl E, Trudell JR, Harris RA. Structural basis for alcohol modulation of a pentameric ligand-gated ion channel. Proceedings of the National Academy of Sciences of the United States of America. 108: 12149-54. PMID 21730162 DOI: 10.1073/Pnas.1104480108  0.448
2011 Howard RJ, Slesinger PA, Davies DL, Das J, Trudell JR, Harris RA. Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution. Alcoholism, Clinical and Experimental Research. 35: 1561-73. PMID 21676006 DOI: 10.1111/J.1530-0277.2011.01502.X  0.382
2011 Howard RJ, Ondricek KE, Trudell JR, Harris RA. Structural Basis for Alcohol Modulation of a Ligand-Gated Ion Channel Homolog Biophysical Journal. 100: 101a. DOI: 10.1016/J.Bpj.2010.12.756  0.464
2007 Howard RJ, Clark KA, Holton JM, Minor DL. Structural insight into KCNQ (Kv7) channel assembly and channelopathy. Neuron. 53: 663-75. PMID 17329207 DOI: 10.1016/J.Neuron.2007.02.010  0.559
2003 Walden H, Podgorski MS, Huang DT, Miller DW, Howard RJ, Minor DL, Holton JM, Schulman BA. The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Molecular Cell. 12: 1427-37. PMID 14690597 DOI: 10.1016/S1097-2765(03)00452-0  0.515
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