Year |
Citation |
Score |
2020 |
Low LA, Mummery C, Berridge BR, Austin CP, Tagle DA. Organs-on-chips: into the next decade. Nature Reviews. Drug Discovery. PMID 32913334 DOI: 10.1038/s41573-020-0079-3 |
0.317 |
|
2019 |
Tambuyzer E, Vandendriessche B, Austin CP, Brooks PJ, Larsson K, Miller Needleman KI, Valentine J, Davies K, Groft SC, Preti R, Oprea TI, Prunotto M. Therapies for rare diseases: therapeutic modalities, progress and challenges ahead. Nature Reviews. Drug Discovery. PMID 31836861 DOI: 10.1038/s41573-019-0049-9 |
0.334 |
|
2019 |
Huang R, Zhu H, Shinn P, Ngan D, Ye L, Thakur A, Grewal G, Zhao T, Southall N, Hall MD, Simeonov A, Austin CP. The NCATS Pharmaceutical Collection: a 10-year update. Drug Discovery Today. PMID 31585169 DOI: 10.1016/J.Drudis.2019.09.019 |
0.328 |
|
2019 |
Huang R, Grishagin I, Wang Y, Zhao T, Greene J, Obenauer JC, Ngan D, Nguyen DT, Guha R, Jadhav A, Southall N, Simeonov A, Austin CP. The NCATS BioPlanet - An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics. Frontiers in Pharmacology. 10: 445. PMID 31133849 DOI: 10.3389/Fphar.2019.00445 |
0.312 |
|
2018 |
Nilubol N, Boufraqech M, Zhang L, Gaskins K, Shen M, Zhang YQ, Gara SK, Austin CP, Kebebew E. Synergistic combination of flavopiridol and carfilzomib targets commonly dysregulated pathways in adrenocortical carcinoma and has biomarkers of response. Oncotarget. 9: 33030-33042. PMID 30250647 DOI: 10.18632/oncotarget.26050 |
0.344 |
|
2018 |
Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, ... ... Austin CP, et al. The Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery. Clinical and Translational Science. PMID 29877628 DOI: 10.1111/Cts.12570 |
0.341 |
|
2018 |
Marshall LJ, Austin CP, Casey W, Fitzpatrick SC, Willett C. Recommendations toward a human pathway-based approach to disease research. Drug Discovery Today. PMID 29870792 DOI: 10.1016/j.drudis.2018.05.038 |
0.323 |
|
2018 |
Huang R, Xia M, Sakamuru S, Zhao J, Lynch C, Zhao T, Zhu H, Austin CP, Simeonov A. Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles. Scientific Reports. 8: 3783. PMID 29491351 DOI: 10.1038/s41598-018-22046-w |
0.36 |
|
2017 |
Wagner JA, Dahlem AM, Hudson LD, Terry SF, Altman RB, Gilliland CT, DeFeo C, Austin CP. Application of a Dynamic Map for Learning, Communicating, Navigating, and Improving Therapeutic Development. Clinical and Translational Science. PMID 29271559 DOI: 10.1111/cts.12531 |
0.315 |
|
2017 |
Dai S, Dulcey AE, Hu X, Wassif CA, Porter FD, Austin CP, Ory DS, Marugan J, Zheng W. Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK. Autophagy. 0. PMID 28613987 DOI: 10.1080/15548627.2017.1329081 |
0.301 |
|
2017 |
Hsu CW, Huang R, Ramos MSA, Austin CP, Simeonov A, Xia M. Advances in high-throughput screening technology for toxicology International Journal of Risk Assessment and Management. 20: 109. DOI: 10.1504/IJRAM.2017.082562 |
0.353 |
|
2016 |
Huang R, Xia M, Sakamuru S, Zhao J, Shahane SA, Attene-Ramos M, Zhao T, Austin CP, Simeonov A. Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization. Nature Communications. 7: 10425. PMID 26811972 DOI: 10.1038/ncomms10425 |
0.333 |
|
2016 |
Brooks PJ, Yang NN, Austin CP. Gene Therapy: The View from NCATS. Human Gene Therapy. 27: 7-13. PMID 26784641 DOI: 10.1089/hum.2016.29018.pjb |
0.341 |
|
2015 |
Colvis CM, Austin CP. The NIH-Industry New Therapeutic Uses Pilot Program: Demonstrating the Power of Crowdsourcing. Assay and Drug Development Technologies. 13: 297-8. PMID 26241208 DOI: 10.1089/adt.2015.29006.cmcdrrr |
0.323 |
|
2015 |
Lee JA, Shinn P, Jaken S, Oliver S, Willard FS, Heidler S, Peery RB, Oler J, Chu S, Southall N, Dexheimer TS, Smallwood J, Huang R, Guha R, Jadhav A, ... ... Austin CP, et al. Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays. Plos One. 10: e0130796. PMID 26177200 DOI: 10.1371/Journal.Pone.0130796 |
0.37 |
|
2015 |
Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, et al. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 161: 1252-1265. PMID 26046436 DOI: 10.1016/J.Cell.2015.05.023 |
0.308 |
|
2015 |
Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou YH, Jack JR, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif AA, Austin CP, Tice RR, et al. Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environmental Health Perspectives. 123: 458-66. PMID 25622337 DOI: 10.1289/Ehp.1408775 |
0.322 |
|
2014 |
Tran TA, Wichterman-Kouznetsova J, Varghese D, Huang R, Huang W, Becker M, Austin CP, Inglese J, Johnson RL, Martinez ED. Identification of small molecule modulators of gene transcription with anticancer activity. Acs Chemical Biology. 9: 2603-11. PMID 25188650 DOI: 10.1021/Cb500532X |
0.387 |
|
2014 |
Huang R, Sakamuru S, Martin MT, Reif DM, Judson RS, Houck KA, Casey W, Hsieh JH, Shockley KR, Ceger P, Fostel J, Witt KL, Tong W, Rotroff DM, Zhao T, ... ... Austin CP, et al. Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway. Scientific Reports. 4: 5664. PMID 25012808 DOI: 10.1038/Srep05664 |
0.354 |
|
2014 |
Yu D, Swaroop M, Wang M, Baxa U, Yang R, Yan Y, Coksaygan T, DeTolla L, Marugan JJ, Austin CP, McKew JC, Gong DW, Zheng W. Niemann-Pick Disease Type C: Induced Pluripotent Stem Cell-Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy. Journal of Biomolecular Screening. 19: 1164-1173. PMID 24907126 DOI: 10.1177/1087057114537378 |
0.337 |
|
2014 |
Blackford JA, Brimacombe KR, Dougherty EJ, Pradhan M, Shen M, Li Z, Auld DS, Chow CC, Austin CP, Simons SS. Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay. Molecular Endocrinology (Baltimore, Md.). 28: 1194-206. PMID 24850414 DOI: 10.1210/Me.2014-1069 |
0.377 |
|
2014 |
Bhattacharyya N, Hu X, Chen CZ, Mathews Griner LA, Zheng W, Inglese J, Austin CP, Marugan JJ, Southall N, Neumann S, Northup JK, Ferrer M, Collins MT. A high throughput screening assay system for the identification of small molecule inhibitors of gsp. Plos One. 9: e90766. PMID 24667240 DOI: 10.1371/Journal.Pone.0090766 |
0.355 |
|
2014 |
Fiskus W, Saba N, Shen M, Ghias M, Liu J, Gupta SD, Chauhan L, Rao R, Gunewardena S, Schorno K, Austin CP, Maddocks K, Byrd J, Melnick A, Huang P, et al. Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia. Cancer Research. 74: 2520-32. PMID 24599128 DOI: 10.1158/0008-5472.Can-13-2033 |
0.336 |
|
2014 |
Mathews Griner LA, Guha R, Shinn P, Young RM, Keller JM, Liu D, Goldlust IS, Yasgar A, McKnight C, Boxer MB, Duveau DY, Jiang JK, Michael S, Mierzwa T, Huang W, ... ... Austin CP, et al. High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 2349-54. PMID 24469833 DOI: 10.1073/Pnas.1311846111 |
0.389 |
|
2014 |
Colvis CM, Austin CP. Innovation in therapeutics development at the NCATS. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 230-2. PMID 24317308 DOI: 10.1038/npp.2013.247 |
0.338 |
|
2014 |
Ottinger EA, Kao ML, Carrillo-Carrasco N, Yanjanin N, Shankar RK, Janssen M, Brewster M, Scott I, Xu X, Cradock J, Terse P, Dehdashti SJ, Marugan J, Zheng W, Portilla L, ... ... Austin CP, et al. Collaborative development of 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick type C1 disease. Current Topics in Medicinal Chemistry. 14: 330-9. PMID 24283970 DOI: 10.2174/1568026613666131127160118 |
0.312 |
|
2014 |
Ketley A, Chen CZ, Li X, Arya S, Robinson TE, Granados-Riveron J, Udosen I, Morris GE, Holt I, Furling D, Chaouch S, Haworth B, Southall N, Shinn P, Zheng W, ... Austin CP, et al. High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines. Human Molecular Genetics. 23: 1551-62. PMID 24179176 DOI: 10.1093/Hmg/Ddt542 |
0.375 |
|
2014 |
Shahane SA, Huang R, Gerhold D, Baxa U, Austin CP, Xia M. Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format. Journal of Biomolecular Screening. 19: 66-76. PMID 24003057 DOI: 10.1177/1087057113502851 |
0.382 |
|
2013 |
Trucco MM, Awad O, Wilky BA, Goldstein SD, Huang R, Walker RL, Shah P, Katuri V, Gul N, Zhu YJ, McCarthy EF, Paz-Priel I, Meltzer PS, Austin CP, Xia M, et al. A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-κB signaling in chordoma biology. Plos One. 8: e79950. PMID 24223206 DOI: 10.1371/Journal.Pone.0079950 |
0.331 |
|
2013 |
Shen M, Zhang Y, Saba N, Austin CP, Wiestner A, Auld DS. Identification of therapeutic candidates for chronic lymphocytic leukemia from a library of approved drugs. Plos One. 8: e75252. PMID 24073257 DOI: 10.1371/journal.pone.0075252 |
0.403 |
|
2013 |
Xia M, Huang R, Sakamuru S, Alcorta D, Cho MH, Lee DH, Park DM, Kelley MJ, Sommer J, Austin CP. Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biology & Therapy. 14: 638-47. PMID 23792643 DOI: 10.4161/cbt.24596 |
0.341 |
|
2013 |
Eastman RT, Pattaradilokrat S, Raj DK, Dixit S, Deng B, Miura K, Yuan J, Tanaka TQ, Johnson RL, Jiang H, Huang R, Williamson KC, Lambert LE, Long C, Austin CP, et al. A class of tricyclic compounds blocking malaria parasite oocyst development and transmission. Antimicrobial Agents and Chemotherapy. 57: 425-35. PMID 23129054 DOI: 10.1128/Aac.00920-12 |
0.319 |
|
2013 |
Mathews LA, Guha R, Shinn P, Young RM, Lim K, Keller J, Liu D, Yasgar A, McKnight C, Boxer MB, Duveau DY, Jiang J, Michael S, Mott BT, Patel PR, ... ... Austin CP, et al. Abstract 4543: High-throughput combination screening identifies novel drug-drug pairings for a Bruton's tyrosine kinase inhibitor against the ABC subtype of diffuse large B-cell lymphomas. Cancer Research. 73: 4543-4543. DOI: 10.1158/1538-7445.Am2013-4543 |
0.398 |
|
2012 |
Sun H, Veith H, Xia M, Austin CP, Tice RR, Huang R. Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug-like Molecules. Molecular Informatics. 31: 783-792. PMID 23459712 DOI: 10.1002/minf.201200065 |
0.342 |
|
2012 |
Nilubol N, Zhang L, Shen M, Zhang YQ, He M, Austin CP, Kebebew E. Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening. Journal of Translational Medicine. 10: 198. PMID 22999104 DOI: 10.1186/1479-5876-10-198 |
0.377 |
|
2012 |
Swaroop M, Thorne N, Rao MS, Austin CP, McKew JC, Zheng W. Evaluation of cholesterol reduction activity of methyl-β-cyclodextrin using differentiated human neurons and astrocytes. Journal of Biomolecular Screening. 17: 1243-51. PMID 22923786 DOI: 10.1177/1087057112456877 |
0.317 |
|
2012 |
Cunningham L, Finckbeiner S, Hyde RK, Southall N, Marugan J, Yedavalli VR, Dehdashti SJ, Reinhold WC, Alemu L, Zhao L, Yeh JR, Sood R, Pommier Y, Austin CP, Jeang KT, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proceedings of the National Academy of Sciences of the United States of America. 109: 14592-7. PMID 22912405 DOI: 10.1073/Pnas.1200037109 |
0.351 |
|
2012 |
Sun H, Xia M, Austin CP, Huang R. Paradigm shift in toxicity testing and modeling. The Aaps Journal. 14: 473-80. PMID 22528508 DOI: 10.1208/s12248-012-9358-1 |
0.349 |
|
2012 |
Sakamuru S, Li X, Attene-Ramos MS, Huang R, Lu J, Shou L, Shen M, Tice RR, Austin CP, Xia M. Application of a homogenous membrane potential assay to assess mitochondrial function. Physiological Genomics. 44: 495-503. PMID 22433785 DOI: 10.1152/physiolgenomics.00161.2011 |
0.318 |
|
2012 |
Goldin E, Zheng W, Motabar O, Southall N, Choi JH, Marugan J, Austin CP, Sidransky E. High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase. Plos One. 7: e29861. PMID 22272254 DOI: 10.1371/Journal.Pone.0029861 |
0.376 |
|
2012 |
Lock EF, Abdo N, Huang R, Xia M, Kosyk O, O'Shea SH, Zhou YH, Sedykh A, Tropsha A, Austin CP, Tice RR, Wright FA, Rusyn I. Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicological Sciences : An Official Journal of the Society of Toxicology. 126: 578-88. PMID 22268004 DOI: 10.1093/Toxsci/Kfs023 |
0.37 |
|
2012 |
Weir SJ, DeGennaro LJ, Austin CP. Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnership. Cancer Research. 72: 1055-8. PMID 22246671 DOI: 10.1158/0008-5472.CAN-11-3439 |
0.323 |
|
2011 |
Huang W, Huang R, Attene-Ramos MS, Sakamuru S, Englund EE, Inglese J, Austin CP, Xia M. Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 5239-43. PMID 21831635 DOI: 10.1016/j.bmcl.2011.07.043 |
0.315 |
|
2011 |
Xiao J, Marugan JJ, Zheng W, Titus S, Southall N, Cherry JJ, Evans M, Androphy EJ, Austin CP. Discovery, synthesis, and biological evaluation of novel SMN protein modulators. Journal of Medicinal Chemistry. 54: 6215-33. PMID 21819082 DOI: 10.1021/Jm200497T |
0.312 |
|
2011 |
Yuan J, Cheng KC, Johnson RL, Huang R, Pattaradilokrat S, Liu A, Guha R, Fidock DA, Inglese J, Wellems TE, Austin CP, Su XZ. Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. Science (New York, N.Y.). 333: 724-9. PMID 21817045 DOI: 10.1126/Science.1205216 |
0.358 |
|
2011 |
Xia M, Guo V, Huang R, Shahane SA, Austin CP, Nirenberg M, Sharma SK. Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format. Cellular and Molecular Neurobiology. 31: 901-7. PMID 21598037 DOI: 10.1007/s10571-011-9689-y |
0.359 |
|
2011 |
Johnson RL, Hwang JY, Arnold LA, Huang R, Wichterman J, Augustinaite I, Austin CP, Inglese J, Guy RK, Huang W. A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2. Journal of Biomolecular Screening. 16: 618-27. PMID 21482722 DOI: 10.1177/1087057111402199 |
0.351 |
|
2011 |
Chen CZ, Kulakova L, Southall N, Marugan JJ, Galkin A, Austin CP, Herzberg O, Zheng W. High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements. Antimicrobial Agents and Chemotherapy. 55: 667-75. PMID 21078930 DOI: 10.1128/Aac.00618-10 |
0.367 |
|
2010 |
Shukla SJ, Huang R, Austin CP, Xia M. The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform. Drug Discovery Today. 15: 997-1007. PMID 20708096 DOI: 10.1016/j.drudis.2010.07.007 |
0.353 |
|
2010 |
Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorganic & Medicinal Chemistry Letters. 20: 3387-93. PMID 20451379 DOI: 10.1016/J.Bmcl.2010.04.015 |
0.309 |
|
2010 |
Miller SC, Huang R, Sakamuru S, Shukla SJ, Attene-Ramos MS, Shinn P, Van Leer D, Leister W, Austin CP, Xia M. Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochemical Pharmacology. 79: 1272-80. PMID 20067776 DOI: 10.1016/j.bcp.2009.12.021 |
0.33 |
|
2010 |
Shen M, Zhang Y, Wiestner AU, Ashlock MA, Austin CP, Auld DS. Abstract 3685: A strategy to identify therapeutic candidates for chronic lymphocytic leukemia from a library of FDA approved drugs Cancer Research. 70: 3685-3685. DOI: 10.1158/1538-7445.Am10-3685 |
0.403 |
|
2009 |
Xia M, Bi K, Huang R, Cho MH, Sakamuru S, Miller SC, Li H, Sun Y, Printen J, Austin CP, Inglese J. Identification of small molecule compounds that inhibit the HIF-1 signaling pathway. Molecular Cancer. 8: 117. PMID 20003191 DOI: 10.1186/1476-4598-8-117 |
0.348 |
|
2009 |
Veith H, Southall N, Huang R, James T, Fayne D, Artemenko N, Shen M, Inglese J, Austin CP, Lloyd DG, Auld DS. Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries. Nature Biotechnology. 27: 1050-5. PMID 19855396 DOI: 10.1038/Nbt.1581 |
0.347 |
|
2009 |
Huang R, Southall N, Xia M, Cho MH, Jadhav A, Nguyen DT, Inglese J, Tice RR, Austin CP. Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 385-93. PMID 19805409 DOI: 10.1093/Toxsci/Kfp231 |
0.32 |
|
2009 |
Lea WA, Xi J, Jadhav A, Lu L, Austin CP, Simeonov A, Eckenhoff RG. A high-throughput approach for identification of novel general anesthetics. Plos One. 4: e7150. PMID 19777064 DOI: 10.1371/Journal.Pone.0007150 |
0.344 |
|
2009 |
Norton JT, Titus SA, Dexter D, Austin CP, Zheng W, Huang S. Automated high-content screening for compounds that disassemble the perinucleolar compartment. Journal of Biomolecular Screening. 14: 1045-53. PMID 19762548 DOI: 10.1177/1087057109343120 |
0.378 |
|
2009 |
Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature Chemical Biology. 5: 765-71. PMID 19734910 DOI: 10.1038/Nchembio.215 |
0.315 |
|
2009 |
Johnson RL, Huang R, Jadhav A, Southall N, Wichterman J, MacArthur R, Xia M, Bi K, Printen J, Austin CP, Inglese J. A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries. Molecular Biosystems. 5: 1039-50. PMID 19668870 DOI: 10.1039/B902021G |
0.358 |
|
2009 |
Titus SA, Beacham D, Shahane SA, Southall N, Xia M, Huang R, Hooten E, Zhao Y, Shou L, Austin CP, Zheng W. A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel. Analytical Biochemistry. 394: 30-8. PMID 19583963 DOI: 10.1016/J.Ab.2009.07.003 |
0.346 |
|
2009 |
Zhu PJ, Hobson JP, Southall N, Qiu C, Thomas CJ, Lu J, Inglese J, Zheng W, Leppla SH, Bugge TH, Austin CP, Liu S. Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death. Bioorganic & Medicinal Chemistry. 17: 5139-45. PMID 19540764 DOI: 10.1016/J.Bmc.2009.05.054 |
0.371 |
|
2009 |
Xia M, Huang R, Sun Y, Semenza GL, Aldred SF, Witt KL, Inglese J, Tice RR, Austin CP. Identification of chemical compounds that induce HIF-1alpha activity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 153-63. PMID 19502547 DOI: 10.1093/Toxsci/Kfp123 |
0.333 |
|
2009 |
Simeonov A, Kulkarni A, Dorjsuren D, Jadhav A, Shen M, McNeill DR, Austin CP, Wilson DM. Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. Plos One. 4: e5740. PMID 19484131 DOI: 10.1371/journal.pone.0005740 |
0.375 |
|
2009 |
Skoumbourdis AP, Leclair CA, Stefan E, Turjanski AG, Maguire W, Titus SA, Huang R, Auld DS, Inglese J, Austin CP, Michnick SW, Xia M, Thomas CJ. Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 3686-92. PMID 19464886 DOI: 10.1016/J.Bmcl.2009.01.057 |
0.301 |
|
2009 |
Yi F, Zhu P, Southall N, Inglese J, Austin CP, Zheng W, Regan L. An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction. Journal of Biomolecular Screening. 14: 273-81. PMID 19211782 DOI: 10.1177/1087057108330114 |
0.357 |
|
2008 |
Titus SA, Li X, Southall N, Lu J, Inglese J, Brasch M, Austin CP, Zheng W. A cell-based PDE4 assay in 1536-well plate format for high-throughput screening. Journal of Biomolecular Screening. 13: 609-18. PMID 18591513 DOI: 10.1177/1087057108319977 |
0.364 |
|
2008 |
Kimple AJ, Yasgar A, Hughes M, Jadhav A, Willard FS, Muller RE, Austin CP, Inglese J, Ibeanu GC, Siderovski DP, Simeonov A. A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction. Combinatorial Chemistry & High Throughput Screening. 11: 396-409. PMID 18537560 DOI: 10.2174/138620708784534770 |
0.333 |
|
2008 |
Cho MH, Niles A, Huang R, Inglese J, Austin CP, Riss T, Xia M. A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker. Toxicology in Vitro : An International Journal Published in Association With Bibra. 22: 1099-106. PMID 18400464 DOI: 10.1016/j.tiv.2008.02.013 |
0.352 |
|
2008 |
Sayed AA, Simeonov A, Thomas CJ, Inglese J, Austin CP, Williams DL. Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nature Medicine. 14: 407-12. PMID 18345010 DOI: 10.1038/Nm1737 |
0.317 |
|
2008 |
Simeonov A, Jadhav A, Sayed AA, Wang Y, Nelson ME, Thomas CJ, Inglese J, Williams DL, Austin CP. Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade. Plos Neglected Tropical Diseases. 2: e127. PMID 18235848 DOI: 10.1371/Journal.Pntd.0000127 |
0.387 |
|
2008 |
Titus S, Neumann S, Zheng W, Southall N, Michael S, Klumpp C, Yasgar A, Shinn P, Thomas CJ, Inglese J, Gershengorn MC, Austin CP. Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor. Journal of Biomolecular Screening. 13: 120-7. PMID 18216391 DOI: 10.1177/1087057107313786 |
0.351 |
|
2008 |
Johnson RL, Huang W, Jadhav A, Austin CP, Inglese J, Martinez ED. A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression. Analytical Biochemistry. 375: 237-48. PMID 18211814 DOI: 10.1016/J.Ab.2007.12.028 |
0.378 |
|
2008 |
Simeonov A, Yasgar A, Jadhav A, Lokesh GL, Klumpp C, Michael S, Austin CP, Natarajan A, Inglese J. Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction. Analytical Biochemistry. 375: 60-70. PMID 18158907 DOI: 10.1016/J.Ab.2007.11.039 |
0.358 |
|
2008 |
Xie Y, Deng S, Thomas CJ, Liu Y, Zhang YQ, Rinderspacher A, Huang W, Gong G, Wyler M, Cayanis E, Aulner N, Többen U, Chung C, Pampou S, Southall N, ... ... Austin CP, et al. Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation. Bioorganic & Medicinal Chemistry Letters. 18: 329-35. PMID 18024113 DOI: 10.1016/J.Bmcl.2007.10.100 |
0.359 |
|
2007 |
Davis RE, Zhang YQ, Southall N, Staudt LM, Austin CP, Inglese J, Auld DS. A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor. Assay and Drug Development Technologies. 5: 85-103. PMID 17355202 DOI: 10.1089/Adt.2006.048 |
0.366 |
|
2004 |
Austin CP, Brady LS, Insel TR, Collins FS. NIH Molecular Libraries Initiative. Science (New York, N.Y.). 306: 1138-9. PMID 15542455 DOI: 10.1126/Science.1105511 |
0.369 |
|
2003 |
Austin CP. The completed human genome: implications for chemical biology. Current Opinion in Chemical Biology. 7: 511-5. PMID 12941427 DOI: 10.1016/S1367-5931(03)00083-8 |
0.301 |
|
2000 |
Cepko CL, Ryder E, Austin C, Golden J, Fields-Berry S, Lin J. Lineage analysis with retroviral vectors. Methods in Enzymology. 327: 118-45. PMID 11044979 DOI: 10.1016/S0076-6879(00)27272-8 |
0.588 |
|
1998 |
Cepko CL, Ryder E, Austin C, Golden J, Fields-Berry S, Lin J. Lineage analysis using retroviral vectors. Methods (San Diego, Calif.). 14: 393-406. PMID 9608510 DOI: 10.1006/Meth.1998.0594 |
0.591 |
|
1996 |
Cepko CL, Austin CP, Yang X, Alexiades M, Ezzeddine D. Cell fate determination in the vertebrate retina. Proceedings of the National Academy of Sciences of the United States of America. 93: 589-95. PMID 8570600 DOI: 10.1073/Pnas.93.2.589 |
0.685 |
|
1995 |
Austin CP, Feldman DE, Ida JA, Cepko CL. Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch. Development (Cambridge, England). 121: 3637-50. PMID 8582277 |
0.491 |
|
1994 |
Austin CP, Cepko CL. Retrovirus mediated gene transduction into the vertebrate CNS. Gene Therapy. 1: S6-9. PMID 8542405 |
0.415 |
|
1993 |
Cepko CL, Ryder EF, Austin CP, Walsh C, Fekete DM. Lineage analysis using retrovirus vectors. Methods in Enzymology. 225: 933-60. PMID 8231895 DOI: 10.1016/0076-6879(93)25059-B |
0.556 |
|
1991 |
Misson JP, Austin CP, Takahashi T, Cepko CL, Caviness VS. The alignment of migrating neural cells in relation to the murine neopallial radial glial fiber system. Cerebral Cortex (New York, N.Y. : 1991). 1: 221-9. PMID 1668365 |
0.438 |
|
1990 |
Cepko CL, Austin CP, Walsh C, Ryder EF, Halliday A, Fields-Berry S. Studies of cortical development using retrovirus vectors. Cold Spring Harbor Symposia On Quantitative Biology. 55: 265-78. PMID 2132820 DOI: 10.1101/Sqb.1990.055.01.029 |
0.529 |
|
1990 |
Austin CP, Cepko CL. Cellular migration patterns in the developing mouse cerebral cortex. Development (Cambridge, England). 110: 713-32. PMID 2088716 |
0.442 |
|
Low-probability matches (unlikely to be authored by this person) |
2019 |
Boycott KM, Lau LP, Cutillo CM, Austin CP. International collaborative actions and transparency to understand, diagnose, and develop therapies for rare diseases. Embo Molecular Medicine. PMID 30979709 DOI: 10.15252/emmm.201910486 |
0.3 |
|
2011 |
Xia M, Shahane SA, Huang R, Titus SA, Shum E, Zhao Y, Southall N, Zheng W, Witt KL, Tice RR, Austin CP. Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicology and Applied Pharmacology. 252: 250-8. PMID 21362439 DOI: 10.1016/J.Taap.2011.02.016 |
0.298 |
|
2007 |
Inglese J, Johnson RL, Simeonov A, Xia M, Zheng W, Austin CP, Auld DS. High-throughput screening assays for the identification of chemical probes. Nature Chemical Biology. 3: 466-79. PMID 17637779 DOI: 10.1038/nchembio.2007.17 |
0.297 |
|
2011 |
Yamamoto KN, Hirota K, Kono K, Takeda S, Sakamuru S, Xia M, Huang R, Austin CP, Witt KL, Tice RR. Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines. Environmental and Molecular Mutagenesis. 52: 547-61. PMID 21538559 DOI: 10.1002/em.20656 |
0.296 |
|
2009 |
MacArthur R, Leister W, Veith H, Shinn P, Southall N, Austin CP, Inglese J, Auld DS. Monitoring compound integrity with cytochrome P450 assays and qHTS. Journal of Biomolecular Screening. 14: 538-46. PMID 19483146 DOI: 10.1177/1087057109336954 |
0.295 |
|
2004 |
Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, et al. The knockout mouse project. Nature Genetics. 36: 921-4. PMID 15340423 DOI: 10.1038/Ng0904-921 |
0.295 |
|
2016 |
Lochmüller H, Le Cam Y, Jonker AH, Lau LP, Baynam G, Kaufmann P, Lasko P, Dawkins HJ, Austin CP, Boycott KM. 'IRDiRC Recognized Resources': a new mechanism to support scientists to conduct efficient, high-quality research for rare diseases. European Journal of Human Genetics : Ejhg. PMID 27782107 DOI: 10.1038/ejhg.2016.137 |
0.295 |
|
2009 |
Motabar O, Shi ZD, Goldin E, Liu K, Southall N, Sidransky E, Austin CP, Griffiths GL, Zheng W. A new resorufin-based alpha-glucosidase assay for high-throughput screening. Analytical Biochemistry. 390: 79-84. PMID 19371716 DOI: 10.1016/J.Ab.2009.04.010 |
0.295 |
|
2009 |
Wang Z, Zheng M, Li Z, Li R, Jia L, Xiong X, Southall N, Wang S, Xia M, Austin CP, Zheng W, Xie Z, Sun Y. Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition. Cancer Research. 69: 6556-64. PMID 19679550 DOI: 10.1158/0008-5472.Can-09-0891 |
0.295 |
|
2013 |
Attene-Ramos MS, Miller N, Huang R, Michael S, Itkin M, Kavlock RJ, Austin CP, Shinn P, Simeonov A, Tice RR, Xia M. The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality. Drug Discovery Today. 18: 716-23. PMID 23732176 DOI: 10.1016/j.drudis.2013.05.015 |
0.294 |
|
2012 |
Xu M, Liu K, Swaroop M, Porter FD, Sidhu R, Firnkes S, Finkes S, Ory DS, Marugan JJ, Xiao J, Southall N, Pavan WJ, Davidson C, Walkley SU, Remaley AT, ... ... Austin CP, et al. δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders. The Journal of Biological Chemistry. 287: 39349-60. PMID 23035117 DOI: 10.1074/Jbc.M112.357707 |
0.294 |
|
2018 |
Kaufmann P, Pariser AR, Austin C. From scientific discovery to treatments for rare diseases - the view from the National Center for Advancing Translational Sciences - Office of Rare Diseases Research. Orphanet Journal of Rare Diseases. 13: 196. PMID 30400963 DOI: 10.1186/s13023-018-0936-x |
0.291 |
|
2019 |
Baynam GS, Groft S, van der Westhuizen FH, Gassman SD, du Plessis K, Coles EP, Selebatso E, Selebatso M, Gaobinelwe B, Selebatso T, Joel D, Llera VA, Vorster BC, Wuebbels B, Djoudalbaye B, ... Austin CP, et al. A call for global action for rare diseases in Africa. Nature Genetics. PMID 31873296 DOI: 10.1038/S41588-019-0552-2 |
0.291 |
|
2017 |
Cutillo CM, Austin CP, Groft SC. A Global Approach to Rare Diseases Research and Orphan Products Development: The International Rare Diseases Research Consortium (IRDiRC). Advances in Experimental Medicine and Biology. 1031: 349-369. PMID 29214582 DOI: 10.1007/978-3-319-67144-4_20 |
0.291 |
|
2012 |
Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, ... ... Austin CP, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nature Chemical Biology. 8: 839-47. PMID 22922757 DOI: 10.1038/Nchembio.1060 |
0.289 |
|
2017 |
Julkowska D, Austin CP, Cutillo CM, Gancberg D, Hager C, Halftermeyer J, Jonker AH, Lau LPL, Norstedt I, Rath A, Schuster R, Simelyte E, van Weely S. The importance of international collaboration for rare diseases research-a European perspective. Gene Therapy. PMID 28440796 DOI: 10.1038/gt.2017.29 |
0.289 |
|
2019 |
Menetski JP, Hoffmann S, Cush S, Kamphaus TN, Austin CP, Herrling P, Wagner JA. The FNIH Biomarkers Consortium: Past Accomplishments and New Strategic Direction. Clinical Pharmacology and Therapeutics. PMID 30648736 DOI: 10.1002/cpt.1362 |
0.288 |
|
2018 |
Xia M, Huang R, Shi Q, Boyd WA, Zhao J, Sun N, Rice JR, Dunlap PE, Hackstadt AJ, Bridge MF, Smith MV, Dai S, Zheng W, Chu PH, Gerhold D, ... ... Austin CP, et al. Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies. Environmental Health Perspectives. 126: 077010. PMID 30059008 DOI: 10.1289/EHP2589 |
0.288 |
|
2013 |
Sun H, Xia M, Shahane SA, Jadhav A, Austin CP, Huang R. Are hERG channel blockers also phospholipidosis inducers? Bioorganic & Medicinal Chemistry Letters. 23: 4587-90. PMID 23856051 DOI: 10.1016/j.bmcl.2013.06.034 |
0.288 |
|
2009 |
Mott BT, Tanega C, Shen M, Maloney DJ, Shinn P, Leister W, Marugan JJ, Inglese J, Austin CP, Misteli T, Auld DS, Thomas CJ. Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk). Bioorganic & Medicinal Chemistry Letters. 19: 6700-5. PMID 19837585 DOI: 10.1016/J.Bmcl.2009.09.121 |
0.287 |
|
2004 |
Austin CP. The impact of the completed human genome sequence on the development of novel therapeutics for human disease. Annual Review of Medicine. 55: 1-13. PMID 14746506 DOI: 10.1146/annurev.med.55.091902.104426 |
0.287 |
|
2007 |
Huang W, Zheng W, Urban DJ, Inglese J, Sidransky E, Austin CP, Thomas CJ. N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease. Bioorganic & Medicinal Chemistry Letters. 17: 5783-9. PMID 17827006 DOI: 10.1016/J.Bmcl.2007.08.050 |
0.286 |
|
2009 |
Shi ZD, Motabar O, Goldin E, Liu K, Southall N, Sidransky E, Austin CP, Griffiths GL, Zheng W. Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase. Analytical and Bioanalytical Chemistry. 394: 1903-9. PMID 19521690 DOI: 10.1007/S00216-009-2879-5 |
0.285 |
|
2012 |
Chen CZ, Sobczak K, Hoskins J, Southall N, Marugan JJ, Zheng W, Thornton CA, Austin CP. Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1. Analytical and Bioanalytical Chemistry. 402: 1889-98. PMID 22218462 DOI: 10.1007/S00216-011-5604-0 |
0.285 |
|
2017 |
Austin CP, Cutillo CM, Lau LP, Jonker AH, Rath A, Julkowska D, Thomson D, Terry S, de Montleau B, Ardigò D, Hivert V, Boycott KM, Baynam G, Kaufmann P, Taruscio D, et al. Future of Rare Diseases Research 2017-2027: an IRDiRC Perspective. Clinical and Translational Science. PMID 28796445 DOI: 10.1111/cts.12500 |
0.283 |
|
2016 |
Walkley SU, Davidson CD, Jacoby J, Marella PD, Ottinger EA, Austin CP, Porter FD, Vite CH, Ory DS. Fostering collaborative research for rare genetic disease: the example of niemann-pick type C disease. Orphanet Journal of Rare Diseases. 11: 161. PMID 27903269 DOI: 10.1186/S13023-016-0540-X |
0.283 |
|
2013 |
Teng C, Goodwin B, Shockley K, Xia M, Huang R, Norris J, Merrick BA, Jetten AM, Austin CP, Tice RR. Bisphenol A affects androgen receptor function via multiple mechanisms. Chemico-Biological Interactions. 203: 556-64. PMID 23562765 DOI: 10.1016/J.Cbi.2013.03.013 |
0.282 |
|
2019 |
Menetski JP, Austin CP, Brady LS, Eakin G, Leptak C, Meltzer A, Wagner JA. The FNIH Biomarkers Consortium embraces the BEST. Nature Reviews. Drug Discovery. 18: 567-568. PMID 31367046 DOI: 10.1038/d41573-019-00015-w |
0.281 |
|
2013 |
Childs-Disney JL, Stepniak-Konieczna E, Tran T, Yildirim I, Park H, Chen CZ, Hoskins J, Southall N, Marugan JJ, Patnaik S, Zheng W, Austin CP, Schatz GC, Sobczak K, Thornton CA, et al. Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules. Nature Communications. 4: 2044. PMID 23806903 DOI: 10.1038/Ncomms3044 |
0.28 |
|
2008 |
Skoumbourdis AP, Huang R, Southall N, Leister W, Guo V, Cho MH, Inglese J, Nirenberg M, Austin CP, Xia M, Thomas CJ. Identification of a potent new chemotype for the selective inhibition of PDE4. Bioorganic & Medicinal Chemistry Letters. 18: 1297-303. PMID 18243697 DOI: 10.1016/J.Bmcl.2008.01.028 |
0.277 |
|
2015 |
Wu J, Cai B, Sun W, Huang R, Liu X, Lin M, Pattaradilokrat S, Martin S, Qi Y, Nair SC, Bolland S, Cohen JI, Austin CP, Long CA, Myers TG, et al. Genome-wide Analysis of Host-Plasmodium yoelii Interactions Reveals Regulators of the Type I Interferon Response. Cell Reports. PMID 26190101 DOI: 10.1016/J.Celrep.2015.06.058 |
0.273 |
|
2010 |
Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Sidransky E, Aungst RA, Liu K, Sadhukhan SK, Austin CP. Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators. European Journal of Medicinal Chemistry. 45: 1880-97. PMID 20206419 DOI: 10.1016/J.Ejmech.2010.01.027 |
0.27 |
|
2007 |
Zheng W, Padia J, Urban DJ, Jadhav A, Goker-Alpan O, Simeonov A, Goldin E, Auld D, LaMarca ME, Inglese J, Austin CP, Sidransky E. Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 13192-7. PMID 17670938 DOI: 10.1073/Pnas.0705637104 |
0.269 |
|
2017 |
Dawkins HJ, Draghia-Akli R, Lasko P, Lau LP, Jonker AH, Cutillo CM, Rath A, Boycott KM, Baynam G, Lochmüller H, Kaufmann P, Cam YL, Hivert V, Austin CP. Progress in rare diseases research 2010-2016: an IRDiRC perspective. Clinical and Translational Science. PMID 28796411 DOI: 10.1111/cts.12501 |
0.266 |
|
2017 |
Ory DS, Ottinger EA, Farhat NY, King KA, Jiang X, Weissfeld L, Berry-Kravis E, Davidson CD, Bianconi S, Keener LA, Rao R, Soldatos A, Sidhu R, Walters KA, Xu X, ... ... Austin CP, et al. Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1-2 trial. Lancet (London, England). PMID 28803710 DOI: 10.1016/S0140-6736(17)31465-4 |
0.265 |
|
2017 |
Lochmüller H, Torrent I Farnell J, Le Cam Y, Jonker AH, Lau LP, Baynam G, Kaufmann P, Dawkins HJ, Lasko P, Austin CP, Boycott KM. The International Rare Diseases Research Consortium: Policies and Guidelines to maximize impact. European Journal of Human Genetics : Ejhg. PMID 29158551 DOI: 10.1038/s41431-017-0008-z |
0.262 |
|
2017 |
Baynam G, Bowman F, Lister K, Walker CE, Pachter N, Goldblatt J, Boycott KM, Gahl WA, Kosaki K, Adachi T, Ishii K, Mahede T, McKenzie F, Townshend S, Slee J, ... ... Austin CP, et al. Improved Diagnosis and Care for Rare Diseases through Implementation of Precision Public Health Framework. Advances in Experimental Medicine and Biology. 1031: 55-94. PMID 29214566 DOI: 10.1007/978-3-319-67144-4_4 |
0.261 |
|
2012 |
Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, et al. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 490: 187-91. PMID 23060188 DOI: 10.1038/Nature11556 |
0.258 |
|
2020 |
Huang R, Xu M, Zhu H, Chen CZ, Lee EM, He S, Shamim K, Bougie D, Huang W, Hall MD, Lo D, Simeonov A, Austin CP, Qiu X, Tang H, et al. Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2. Biorxiv : the Preprint Server For Biology. PMID 32766591 DOI: 10.1101/2020.07.27.223578 |
0.257 |
|
2016 |
Gilliland CT, Zuk D, Kocis P, Johnson M, Hay S, Hajduch M, Bietrix F, Aversa G, Austin CP, Ussi AE. Putting translational science on to a global stage. Nature Reviews. Drug Discovery. 15: 217-8. PMID 27032820 DOI: 10.1038/nrd.2016.33 |
0.256 |
|
2009 |
Dorjsuren D, Wilson DM, Beard WA, McDonald JP, Austin CP, Woodgate R, Wilson SH, Simeonov A. A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic Acids Research. 37: e128. PMID 19684079 DOI: 10.1093/Nar/Gkp641 |
0.255 |
|
2018 |
Perry ME, Valdes KM, Wilder E, Austin CP, Brooks PJ. Genome editing to 're-write' wrongs. Nature Reviews. Drug Discovery. PMID 29930285 DOI: 10.1038/nrd.2018.91 |
0.252 |
|
2021 |
Huang R, Xu M, Zhu H, Chen CZ, Zhu W, Lee EM, He S, Zhang L, Zhao J, Shamim K, Bougie D, Huang W, Xia M, Hall MD, Lo D, ... ... Austin CP, et al. Biological activity-based modeling identifies antiviral leads against SARS-CoV-2. Nature Biotechnology. PMID 33623157 DOI: 10.1038/s41587-021-00839-1 |
0.249 |
|
2012 |
Shukla SJ, Huang R, Simmons SO, Tice RR, Witt KL, Vanleer D, Ramabhadran R, Austin CP, Xia M. Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach. Environmental Health Perspectives. 120: 1150-6. PMID 22551509 DOI: 10.1289/ehp.1104709 |
0.249 |
|
2020 |
Tambuyzer E, Vandendriessche B, Austin CP, Brooks PJ, Larsson K, Needleman KIM, Valentine J, Davies K, Groft SC, Preti R, Oprea TI, Prunotto M. Publisher Correction: Therapies for rare diseases: therapeutic modalities, progress and challenges ahead. Nature Reviews. Drug Discovery. PMID 31913355 DOI: 10.1038/s41573-019-0059-7 |
0.245 |
|
2009 |
Parham F, Austin C, Southall N, Huang R, Tice R, Portier C. Dose-response modeling of high-throughput screening data. Journal of Biomolecular Screening. 14: 1216-27. PMID 19828774 DOI: 10.1177/1087057109349355 |
0.237 |
|
2011 |
Yuan P, Tragon T, Xia M, Leclair CA, Skoumbourdis AP, Zheng W, Thomas CJ, Huang R, Austin CP, Chen G, Guitart X. Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents. Pharmacology, Biochemistry, and Behavior. 98: 349-55. PMID 21296104 DOI: 10.1016/J.Pbb.2011.02.001 |
0.237 |
|
2006 |
Inglese J, Auld DS, Jadhav A, Johnson RL, Simeonov A, Yasgar A, Zheng W, Austin CP. Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proceedings of the National Academy of Sciences of the United States of America. 103: 11473-8. PMID 16864780 DOI: 10.1073/pnas.0604348103 |
0.236 |
|
2011 |
Leister KP, Huang R, Goodwin BL, Chen A, Austin CP, Xia M. Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells. Current Chemical Genomics. 5: 21-9. PMID 21643507 DOI: 10.2174/1875397301105010021 |
0.236 |
|
2008 |
Liu K, Titus S, Southall N, Zhu P, Inglese J, Austin CP, Zheng W. Comparison on functional assays for Gq-coupled GPCRs by measuring inositol monophospate-1 and intracellular calcium in 1536-well plate format. Current Chemical Genomics. 1: 70-8. PMID 20161830 DOI: 10.2174/1875397300801010070 |
0.236 |
|
2012 |
Fox JT, Sakamuru S, Huang R, Teneva N, Simmons SO, Xia M, Tice RR, Austin CP, Myung K. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proceedings of the National Academy of Sciences of the United States of America. 109: 5423-8. PMID 22431602 DOI: 10.1073/Pnas.1114278109 |
0.236 |
|
2008 |
Michael S, Auld D, Klumpp C, Jadhav A, Zheng W, Thorne N, Austin CP, Inglese J, Simeonov A. A robotic platform for quantitative high-throughput screening. Assay and Drug Development Technologies. 6: 637-57. PMID 19035846 DOI: 10.1089/adt.2008.150 |
0.235 |
|
2009 |
Xia M, Huang R, Guo V, Southall N, Cho MH, Inglese J, Austin CP, Nirenberg M. Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory. Proceedings of the National Academy of Sciences of the United States of America. 106: 2412-7. PMID 19196967 DOI: 10.1073/Pnas.0813020106 |
0.235 |
|
2021 |
Chen Y, Tristan CA, Chen L, Jovanovic VM, Malley C, Chu PH, Ryu S, Deng T, Ormanoglu P, Tao D, Fang Y, Slamecka J, Hong H, LeClair CA, Michael S, ... Austin CP, et al. A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells. Nature Methods. PMID 33941937 DOI: 10.1038/s41592-021-01126-2 |
0.234 |
|
2009 |
Xia M, Guo V, Huang R, Inglese J, Nirenberg M, Austin CP. A Cell-based beta-Lactamase Reporter Gene Assay for the CREB Signaling Pathway. Current Chemical Genomics. 3: 7-12. PMID 19936037 DOI: 10.2174/1875397300903010007 |
0.231 |
|
2013 |
Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, Patnaik S, Marugan J, Damadzic R, Dehdashti SJ, Schwandt ML, Southall N, Austin CP, Eskay R, Ciccocioppo R, et al. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 10132-42. PMID 23761908 DOI: 10.1523/Jneurosci.4742-12.2013 |
0.231 |
|
2008 |
Huang R, Southall N, Cho MH, Xia M, Inglese J, Austin CP. Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening. Chemical Research in Toxicology. 21: 659-67. PMID 18281954 DOI: 10.1021/Tx700365E |
0.228 |
|
2011 |
Huang R, Southall N, Wang Y, Yasgar A, Shinn P, Jadhav A, Nguyen DT, Austin CP. The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. Science Translational Medicine. 3: 80ps16. PMID 21525397 DOI: 10.1126/Scitranslmed.3001862 |
0.228 |
|
2011 |
Huang R, Xia M, Cho MH, Sakamuru S, Shinn P, Houck KA, Dix DJ, Judson RS, Witt KL, Kavlock RJ, Tice RR, Austin CP. Chemical genomics profiling of environmental chemical modulation of human nuclear receptors. Environmental Health Perspectives. 119: 1142-8. PMID 21543282 DOI: 10.1289/ehp.1002952 |
0.227 |
|
2008 |
Zhu PJ, Zheng W, Auld DS, Jadhav A, Macarthur R, Olson KR, Peng K, Dotimas H, Austin CP, Inglese J. A miniaturized glucocorticoid receptor translocation assay using enzymatic fragment complementation evaluated with qHTS. Combinatorial Chemistry & High Throughput Screening. 11: 545-59. PMID 18694391 DOI: 10.2174/138620708785204045 |
0.224 |
|
2009 |
Shukla SJ, Nguyen DT, Macarthur R, Simeonov A, Frazee WJ, Hallis TM, Marks BD, Singh U, Eliason HC, Printen J, Austin CP, Inglese J, Auld DS. Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening. Assay and Drug Development Technologies. 7: 143-69. PMID 19505231 DOI: 10.1089/adt.2009.193 |
0.223 |
|
2021 |
Hall MD, Anderson JM, Anderson A, Baker D, Bradner J, Brimacombe KR, Campbell EA, Corbett KS, Carter K, Cherry S, Chiang L, Cihlar T, de Wit E, Denison M, Disney M, ... ... Austin CP, et al. Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit. The Journal of Infectious Diseases. PMID 34111271 DOI: 10.1093/infdis/jiab305 |
0.22 |
|
2010 |
Quinn AM, Bedford MT, Espejo A, Spannhoff A, Austin CP, Oppermann U, Simeonov A. A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic Acids Research. 38: e11. PMID 19897549 DOI: 10.1093/Nar/Gkp899 |
0.22 |
|
2012 |
Sun H, Shahane S, Xia M, Austin CP, Huang R. Structure based model for the prediction of phospholipidosis induction potential of small molecules. Journal of Chemical Information and Modeling. 52: 1798-805. PMID 22725677 DOI: 10.1021/ci3001875 |
0.219 |
|
2020 |
Richard AM, Huang R, Waidyanatha S, Shinn P, Collins BJ, Thillainadarajah I, Grulke CM, Williams AJ, Lougee RR, Judson RS, Houck KA, Shobair M, Yang C, Rathman JF, Yasgar A, ... ... Austin CP, et al. The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology. Chemical Research in Toxicology. PMID 33140634 DOI: 10.1021/acs.chemrestox.0c00264 |
0.219 |
|
2011 |
Shukla SJ, Sakamuru S, Huang R, Moeller TA, Shinn P, Vanleer D, Auld DS, Austin CP, Xia M. Identification of clinically used drugs that activate pregnane X receptors. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 151-9. PMID 20966043 DOI: 10.1124/dmd.110.035105 |
0.217 |
|
2017 |
Johnston SC, Austin CP, Lewis-Hall F. Voluntary Site Accreditation - Improving the Execution of Multicenter Clinical Trials. The New England Journal of Medicine. 377: 1414-1415. PMID 29020596 DOI: 10.1056/NEJMp1709203 |
0.213 |
|
2010 |
Jadhav A, Ferreira RS, Klumpp C, Mott BT, Austin CP, Inglese J, Thomas CJ, Maloney DJ, Shoichet BK, Simeonov A. Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. Journal of Medicinal Chemistry. 53: 37-51. PMID 19908840 DOI: 10.1021/Jm901070C |
0.213 |
|
2008 |
Urban DJ, Zheng W, Goker-Alpan O, Jadhav A, Lamarca ME, Inglese J, Sidransky E, Austin CP. Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening. Combinatorial Chemistry & High Throughput Screening. 11: 817-24. PMID 19075603 DOI: 10.2174/138620708786734244 |
0.212 |
|
2013 |
Attene-Ramos MS, Huang R, Sakamuru S, Witt KL, Beeson GC, Shou L, Schnellmann RG, Beeson CC, Tice RR, Austin CP, Xia M. Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening. Chemical Research in Toxicology. 26: 1323-32. PMID 23895456 DOI: 10.1021/Tx4001754 |
0.211 |
|
2011 |
Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Westbroek W, Stubblefield BK, Sidransky E, Aungst RA, Lea WA, Simeonov A, Leister W, Austin CP. Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. Journal of Medicinal Chemistry. 54: 1033-58. PMID 21250698 DOI: 10.1021/Jm1008902 |
0.211 |
|
2012 |
Heidebrecht RW, Mulrooney C, Austin CP, Barker RH, Beaudoin JA, Cheng KC, Comer E, Dandapani S, Dick J, Duvall JR, Ekland EH, Fidock DA, Fitzgerald ME, Foley M, Guha R, et al. Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria. Acs Medicinal Chemistry Letters. 3: 112-117. PMID 22328964 DOI: 10.1021/Ml200244K |
0.211 |
|
2017 |
Wagner J, Dahlem AM, Hudson LD, Terry SF, Altman RB, Gilliland CT, DeFeo C, Austin CP. A dynamic map for learning, communicating, navigating and improving therapeutic development. Nature Reviews. Drug Discovery. PMID 29269942 DOI: 10.1038/nrd.2017.217 |
0.211 |
|
2007 |
Feng BY, Simeonov A, Jadhav A, Babaoglu K, Inglese J, Shoichet BK, Austin CP. A high-throughput screen for aggregation-based inhibition in a large compound library. Journal of Medicinal Chemistry. 50: 2385-90. PMID 17447748 DOI: 10.1021/Jm061317Y |
0.208 |
|
2011 |
Sun H, Veith H, Xia M, Austin CP, Huang R. Predictive models for cytochrome p450 isozymes based on quantitative high throughput screening data. Journal of Chemical Information and Modeling. 51: 2474-81. PMID 21905670 DOI: 10.1021/ci200311w |
0.206 |
|
2015 |
Langley G, Austin CP, Balapure AK, Birnbaum LS, Bucher JR, Fentem J, Fitzpatrick SC, Fowle JR, Kavlock RJ, Kitano H, Lidbury BA, Muotri AR, Peng SQ, Sakharov D, Seidle T, et al. Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research. Environmental Health Perspectives. 123: A268-72. PMID 26523530 DOI: 10.1289/Ehp.1510345 |
0.203 |
|
2008 |
Babaoglu K, Simeonov A, Irwin JJ, Nelson ME, Feng B, Thomas CJ, Cancian L, Costi MP, Maltby DA, Jadhav A, Inglese J, Austin CP, Shoichet BK. Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase. Journal of Medicinal Chemistry. 51: 2502-11. PMID 18333608 DOI: 10.1021/Jm701500E |
0.201 |
|
2013 |
Tice RR, Austin CP, Kavlock RJ, Bucher JR. Improving the human hazard characterization of chemicals: a Tox21 update. Environmental Health Perspectives. 121: 756-65. PMID 23603828 DOI: 10.1289/ehp.1205784 |
0.201 |
|
2018 |
Austin CP, Colvis CM, Southall NT. Deconstructing the Translational Tower of Babel. Clinical and Translational Science. PMID 30412342 DOI: 10.1111/Cts.12595 |
0.201 |
|
2006 |
Parker CN, Shamu CE, Kraybill B, Austin CP, Bajorath J. Measure, mine, model, and manipulate: the future for HTS and chemoinformatics? Drug Discovery Today. 11: 863-5. PMID 16997135 DOI: 10.1016/j.drudis.2006.08.006 |
0.196 |
|
2013 |
Dehdashti SJ, Zheng W, Gever JR, Wilhelm R, Nguyen DT, Sittampalam G, McKew JC, Austin CP, Prusiner SB. A high-throughput screening assay for determining cellular levels of total tau protein. Current Alzheimer Research. 10: 679-87. PMID 23905996 DOI: 10.2174/15672050113109990143 |
0.192 |
|
2008 |
Lea WA, Jadhav A, Rai G, Sayed AA, Cass CL, Inglese J, Williams DL, Austin CP, Simeonov A. A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase. Assay and Drug Development Technologies. 6: 551-5. PMID 18665782 DOI: 10.1089/adt.2008.149 |
0.192 |
|
2013 |
Huh JR, Englund EE, Wang H, Huang R, Huang P, Rastinejad F, Inglese J, Austin CP, Johnson RL, Huang W, Littman DR. Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors. Acs Medicinal Chemistry Letters. 4: 79-84. PMID 24040486 DOI: 10.1021/Ml300286H |
0.189 |
|
2015 |
Attene-Ramos MS, Huang R, Michael S, Witt KL, Richard A, Tice RR, Simeonov A, Austin CP, Xia M. Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential. Environmental Health Perspectives. 123: 49-56. PMID 25302578 DOI: 10.1289/ehp.1408642 |
0.189 |
|
2009 |
Marchand C, Lea WA, Jadhav A, Dexheimer TS, Austin CP, Inglese J, Pommier Y, Simeonov A. Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay. Molecular Cancer Therapeutics. 8: 240-8. PMID 19139134 DOI: 10.1158/1535-7163.Mct-08-0878 |
0.186 |
|
2012 |
Titus SA, Southall N, Marugan J, Austin CP, Zheng W. High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model. Current Chemical Genomics. 6: 79-86. PMID 23346268 DOI: 10.2174/1875397301206010079 |
0.182 |
|
2010 |
Boxer MB, Jiang JK, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Journal of Medicinal Chemistry. 53: 1048-55. PMID 20017496 DOI: 10.1021/Jm901577G |
0.181 |
|
2013 |
Judson R, Kavlock R, Martin M, Reif D, Houck K, Knudsen T, Richard A, Tice RR, Whelan M, Xia M, Huang R, Austin C, Daston G, Hartung T, Fowle JR, et al. Perspectives on validation of high-throughput assays supporting 21st century toxicity testing. Altex. 30: 51-6. PMID 23338806 DOI: 10.14573/Altex.2013.1.051 |
0.18 |
|
2019 |
Duncan KK, Rudnicki DD, Austin CP, Tagle DA. Exploring Novel Biologically-Relevant Chemical Space Through Artificial Intelligence: The NCATS ASPIRE Program. Frontiers in Robotics and Ai. 6: 143. PMID 33501158 DOI: 10.3389/frobt.2019.00143 |
0.178 |
|
2008 |
Auld DS, Southall NT, Jadhav A, Johnson RL, Diller DJ, Simeonov A, Austin CP, Inglese J. Characterization of chemical libraries for luciferase inhibitory activity. Journal of Medicinal Chemistry. 51: 2372-86. PMID 18363348 DOI: 10.1021/Jm701302V |
0.177 |
|
2010 |
Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, et al. Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. Journal of Medicinal Chemistry. 53: 52-60. PMID 19908842 DOI: 10.1021/Jm901069A |
0.177 |
|
2008 |
Xia M, Huang R, Witt KL, Southall N, Fostel J, Cho MH, Jadhav A, Smith CS, Inglese J, Portier CJ, Tice RR, Austin CP. Compound cytotoxicity profiling using quantitative high-throughput screening. Environmental Health Perspectives. 116: 284-91. PMID 18335092 DOI: 10.1289/Ehp.10727 |
0.174 |
|
2006 |
Auld DS, Johnson RL, Zhang YQ, Veith H, Jadhav A, Yasgar A, Simeonov A, Zheng W, Martinez ED, Westwick JK, Austin CP, Inglese J. Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format. Methods in Enzymology. 414: 566-89. PMID 17110211 DOI: 10.1016/S0076-6879(06)14029-X |
0.168 |
|
2009 |
Crowe A, Huang W, Ballatore C, Johnson RL, Hogan AM, Huang R, Wichterman J, McCoy J, Huryn D, Auld DS, Smith AB, Inglese J, Trojanowski JQ, Austin CP, Brunden KR, et al. Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening. Biochemistry. 48: 7732-45. PMID 19580328 DOI: 10.1021/Bi9006435 |
0.167 |
|
2009 |
Brimacombe KR, Hall MD, Auld DS, Inglese J, Austin CP, Gottesman MM, Fung KL. A dual-fluorescence high-throughput cell line system for probing multidrug resistance. Assay and Drug Development Technologies. 7: 233-49. PMID 19548831 DOI: 10.1089/Adt.2008.165 |
0.166 |
|
2014 |
Hoskins JW, Ofori LO, Chen CZ, Kumar A, Sobczak K, Nakamori M, Southall N, Patnaik S, Marugan JJ, Zheng W, Austin CP, Disney MD, Miller BL, Thornton CA. Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects. Nucleic Acids Research. 42: 6591-602. PMID 24799433 DOI: 10.1093/Nar/Gku275 |
0.162 |
|
2008 |
Yasgar A, Shinn P, Jadhav A, Auld D, Michael S, Zheng W, Austin CP, Inglese J, Simeonov A. Compound Management for Quantitative High-Throughput Screening. Jala (Charlottesville, Va.). 13: 79-89. PMID 18496600 DOI: 10.1016/j.jala.2007.12.004 |
0.161 |
|
2009 |
Auld DS, Zhang YQ, Southall NT, Rai G, Landsman M, MacLure J, Langevin D, Thomas CJ, Austin CP, Inglese J. A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. Journal of Medicinal Chemistry. 52: 1450-8. PMID 19215089 DOI: 10.1021/Jm8014525 |
0.16 |
|
2013 |
Shen M, Zhang Y, Saba N, Austin CP, Wiestner A, Auld DS. Correction: Identification of Therapeutic Candidates for Chronic Lymphocytic Leukemia from a Library of Approved Drugs Plos One. 8. DOI: 10.1371/annotation/e2536fcb-3ab3-44a0-8eab-91aaeb8e49b6 |
0.159 |
|
2011 |
Englund EE, Neumann S, Eliseeva E, McCoy JG, Titus S, Zheng W, Southall N, Shin P, Leister W, Thomas CJ, Inglese J, Austin CP, Gershengorn MC, Huang W. The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists. Medchemcomm. 2: 1016-1020. PMID 22408719 DOI: 10.1039/C1Md00145K |
0.156 |
|
2009 |
Rai G, Sayed AA, Lea WA, Luecke HF, Chakrapani H, Prast-Nielsen S, Jadhav A, Leister W, Shen M, Inglese J, Austin CP, Keefer L, Arnér ES, Simeonov A, Maloney DJ, et al. Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. Journal of Medicinal Chemistry. 52: 6474-83. PMID 19761212 DOI: 10.1021/Jm901021K |
0.156 |
|
2003 |
Figueroa DJ, Borish L, Baramki D, Philip G, Austin CP, Evans JF. Expression of cysteinyl leukotriene synthetic and signalling proteins in inflammatory cells in active seasonal allergic rhinitis. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 33: 1380-8. PMID 14519144 DOI: 10.1046/j.1365-2222.2003.01786.x |
0.155 |
|
2009 |
Thomas CJ, Auld DS, Huang R, Huang W, Jadhav A, Johnson RL, Leister W, Maloney DJ, Marugan JJ, Michael S, Simeonov A, Southall N, Xia M, Zheng W, Inglese J, ... Austin CP, et al. The pilot phase of the NIH Chemical Genomics Center. Current Topics in Medicinal Chemistry. 9: 1181-93. PMID 19807664 DOI: 10.2174/156802609789753644 |
0.151 |
|
2010 |
Judson RS, Martin MT, Reif DM, Houck KA, Knudsen TB, Rotroff DM, Xia M, Sakamuru S, Huang R, Shinn P, Austin CP, Kavlock RJ, Dix DJ. Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity. Environmental Science & Technology. 44: 5979-85. PMID 20602530 DOI: 10.1021/Es102150Z |
0.149 |
|
2022 |
Korn D, Thieme AJ, Alves VM, Yeakey M, Borba JVVB, Capuzzi SJ, Fecho K, Bizon C, Edwards SW, Chirkova R, Colvis CM, Southall NT, Austin CP, Muratov EN, Tropsha A. Defining clinical outcome pathways. Drug Discovery Today. PMID 35182735 DOI: 10.1016/j.drudis.2022.02.008 |
0.147 |
|
1999 |
Chen F, Figueroa DJ, Marmorstein AD, Zhang Q, Petrukhin K, Caskey CT, Austin CP. Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Müller glial cells. Proceedings of the National Academy of Sciences of the United States of America. 96: 15149-54. PMID 10611353 DOI: 10.1073/Pnas.96.26.15149 |
0.147 |
|
2022 |
Faupel-Badger JM, Vogel AL, Hussain SF, Austin CP, Hall MD, Ness E, Sanderson P, Terse PS, Xu X, Balakrishnan K, Patnaik S, Marugan JJ, Rudloff U, Ferrer M. Teaching principles of translational science to a broad scientific audience using a case study approach: A pilot course from the National Center for Advancing Translational Sciences. Journal of Clinical and Translational Science. 6: e66. PMID 35754433 DOI: 10.1017/cts.2022.374 |
0.146 |
|
2009 |
Neumann S, Huang W, Titus S, Krause G, Kleinau G, Alberobello AT, Zheng W, Southall NT, Inglese J, Austin CP, Celi FS, Gavrilova O, Thomas CJ, Raaka BM, Gershengorn MC. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 12471-6. PMID 19592511 DOI: 10.1073/Pnas.0904506106 |
0.145 |
|
2002 |
Figueroa DJ, Morris JA, Ma L, Kandpal G, Chen E, Li YM, Austin CP. Presenilin-dependent gamma-secretase activity modulates neurite outgrowth. Neurobiology of Disease. 9: 49-60. PMID 11848684 DOI: 10.1006/nbdi.2001.0447 |
0.143 |
|
2021 |
Austin CP. Opportunities and Challenges in Translational Science. Clinical and Translational Science. PMID 33982407 DOI: 10.1111/cts.13055 |
0.139 |
|
1998 |
Petrukhin K, Koisti MJ, Bakall B, Li W, Xie G, Marknell T, Sandgren O, Forsman K, Holmgren G, Andreasson S, Vujic M, Bergen AA, McGarty-Dugan V, Figueroa D, Austin CP, et al. Identification of the gene responsible for Best macular dystrophy. Nature Genetics. 19: 241-7. PMID 9662395 DOI: 10.1038/915 |
0.138 |
|
2003 |
Williams JB, Mallorga PJ, Lemaire W, Williams DL, Na S, Patel S, Conn PJ, Conn JP, Pettibone DJ, Austin C, Sur C. Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity. Analytical Biochemistry. 321: 31-7. PMID 12963052 DOI: 10.1016/S0003-2697(03)00431-7 |
0.137 |
|
1998 |
AUSTIN C. The genomics revolution and its implications for new drug discovery American Journal of Hypertension. 11: 242A. DOI: 10.1016/S0895-7061(97)91608-3 |
0.137 |
|
2019 |
Sittampalam GS, Rudnicki DD, Tagle DA, Simeonov A, Austin CP. Mapping biologically active chemical space to accelerate drug discovery. Nature Reviews. Drug Discovery. 18: 83-84. PMID 30710133 DOI: 10.1038/d41573-018-00007-2 |
0.134 |
|
2008 |
Simeonov A, Jadhav A, Thomas CJ, Wang Y, Huang R, Southall NT, Shinn P, Smith J, Austin CP, Auld DS, Inglese J. Fluorescence spectroscopic profiling of compound libraries. Journal of Medicinal Chemistry. 51: 2363-71. PMID 18363325 DOI: 10.1021/Jm701301M |
0.134 |
|
2002 |
Tan CP, Sano H, Iwaasa H, Pan J, Sailer AW, Hreniuk DL, Feighner SD, Palyha OC, Pong SS, Figueroa DJ, Austin CP, Jiang MM, Yu H, Ito J, Ito M, et al. Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. Genomics. 79: 785-92. PMID 12036292 DOI: 10.1006/geno.2002.6771 |
0.133 |
|
2021 |
Austin CP, Mount BA, Colvis CM. Envisioning an actionable research agenda to facilitate repurposing of off-patent drugs. Nature Reviews. Drug Discovery. PMID 34045734 DOI: 10.1038/d41573-021-00090-y |
0.133 |
|
2013 |
Patnaik S, Marugan JJ, Liu K, Zheng W, Southall N, Dehdashti SJ, Thorsell A, Heilig M, Bell L, Zook M, Eskay B, Brimacombe KR, Austin CP. Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor. Journal of Medicinal Chemistry. 56: 9045-56. PMID 24171469 DOI: 10.1021/Jm400904M |
0.13 |
|
2011 |
Shukla SJ, Sakamuru S, Huang R, Moeller TA, Shinn P, VanLeer D, Auld DS, Austin CP, Xia M. Identification of clinically utilized drugs that activate pregnane X receptors (Drug Metabolism and Disposition (2011) 39 (151-159)) Drug Metabolism and Disposition. 39: 351. DOI: 10.1124/dmd.39.2.351 |
0.128 |
|
2011 |
Hwang JY, Huang W, Arnold LA, Huang R, Attia RR, Connelly M, Wichterman J, Zhu F, Augustinaite I, Austin CP, Inglese J, Johnson RL, Guy RK. Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone. The Journal of Biological Chemistry. 286: 11895-908. PMID 21321127 DOI: 10.1074/jbc.M110.200436 |
0.128 |
|
1999 |
Liu Q, Pong SS, Zeng Z, Zhang Q, Howard AD, Williams DL, Davidoff M, Wang R, Austin CP, McDonald TP, Bai C, George SR, Evans JF, Caskey CT. Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14. Biochemical and Biophysical Research Communications. 266: 174-8. PMID 10581185 DOI: 10.1006/Bbrc.1999.1796 |
0.127 |
|
2002 |
Parent SA, Zhang T, Chrebet G, Clemas JA, Figueroa DJ, Ky B, Blevins RA, Austin CP, Rosen H. Molecular characterization of the murine SIGNR1 gene encoding a C-type lectin homologous to human DC-SIGN and DC-SIGNR. Gene. 293: 33-46. PMID 12137941 DOI: 10.1016/S0378-1119(02)00722-9 |
0.127 |
|
2016 |
Abera MB, Xiao J, Nofziger J, Titus S, Southall N, Zheng W, Moritz KE, Ferrer M, Cherry JJ, Androphy EJ, Wang A, Xu X, Austin C, Fischbeck KH, Marugan JJ, et al. ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice. Jci Insight. 1: e88427. PMID 27882347 DOI: 10.1172/Jci.Insight.88427 |
0.125 |
|
2006 |
Hobson J, Liu S, Rønø B, Zheng W, Zhu P, Austin C, Inglese J, Leppla S, Bugge T. ID: 296 Non-invasive, optical imaging of specific cell surface proteolytic activity in single living cells Journal of Thrombosis and Haemostasis. 4: 95-95. DOI: 10.1111/j.1538-7836.2006.00296.x |
0.124 |
|
2018 |
Gan HM, Austin C, Linton S. Transcriptome-Guided Identification of Carbohydrate Active Enzymes (CAZy) from the Christmas Island Red Crab, Gecarcoidea natalis and a Vote for the Inclusion of Transcriptome-Derived Crustacean CAZys in Comparative Studies. Marine Biotechnology (New York, N.Y.). PMID 29995174 DOI: 10.1007/s10126-018-9836-2 |
0.123 |
|
2001 |
Hui Y, Yang G, Galczenski H, Figueroa DJ, Austin CP, Copeland NG, Gilbert DJ, Jenkins NA, Funk CD. The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. The Journal of Biological Chemistry. 276: 47489-95. PMID 11591709 DOI: 10.1074/jbc.M107556200 |
0.122 |
|
2002 |
Kurtz MM, Wang R, Clements MK, Cascieri MA, Austin CP, Cunningham BR, Chicchi GG, Liu Q. Identification, localization and receptor characterization of novel mammalian substance P-like peptides. Gene. 296: 205-12. PMID 12383518 |
0.122 |
|
2010 |
Liu K, Southall N, Titus SA, Inglese J, Eskay RL, Shinn P, Austin CP, Heilig MA, Zheng W. A multiplex calcium assay for identification of GPCR agonists and antagonists. Assay and Drug Development Technologies. 8: 367-79. PMID 20230302 DOI: 10.1089/Adt.2009.0245 |
0.121 |
|
2003 |
Woods JW, Tanen M, Figueroa DJ, Biswas C, Zycband E, Moller DE, Austin CP, Berger JP. Localization of PPARdelta in murine central nervous system: expression in oligodendrocytes and neurons. Brain Research. 975: 10-21. PMID 12763589 |
0.121 |
|
2024 |
Karsan RB, O'Sullivan KE, Lockhart CJ, Austin C. Repair of a fistula between the aorta and right ventricular outflow tract secondary to infective endocarditis of a unicuspid aortic valve and previously repaired ventricular septal defect. Journal of Cardiothoracic Surgery. 19: 236. PMID 38627814 DOI: 10.1186/s13019-024-02746-3 |
0.12 |
|
2019 |
Gilliland CT, White J, Gee B, Kreeftmeijer-Vegter R, Bietrix F, Ussi AE, Hajduch M, Kocis P, Chiba N, Hirasawa R, Suematsu M, Bryans J, Newman S, Hall MD, Austin CP. The Fundamental Characteristics of a Translational Scientist. Acs Pharmacology & Translational Science. 2: 213-216. PMID 32259057 DOI: 10.1021/acsptsci.9b00022 |
0.118 |
|
2019 |
Fukushima M, Austin C, Sato N, Maruyama T, Navarro E, Rocca M, Demotes J, Haendel M, Volchenboum SL, Cowperthwaite M, Silverstein JC, Webb C, Sim I, Chase M, Speakman J, et al. The Global academic research organization network: Data sharing to cure diseases and enable learning health systems. Learning Health Systems. 3: e10073. PMID 31245596 DOI: 10.1002/lrh2.10073 |
0.118 |
|
2007 |
Honson NS, Johnson RL, Huang W, Inglese J, Austin CP, Kuret J. Differentiating Alzheimer disease-associated aggregates with small molecules. Neurobiology of Disease. 28: 251-60. PMID 17761424 DOI: 10.1016/J.Nbd.2007.07.018 |
0.118 |
|
2010 |
McCoy JG, Marugan JJ, Liu K, Zheng W, Southall N, Huang W, Heilig M, Austin CP. Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor. Acs Chemical Neuroscience. 1: 559-574. PMID 21116448 DOI: 10.1021/Cn100040H |
0.116 |
|
2001 |
Clements MK, McDonald TP, Wang R, Xie G, O'Dowd BF, George SR, Austin CP, Liu Q. FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. Biochemical and Biophysical Research Communications. 284: 1189-93. PMID 11414709 DOI: 10.1006/Bbrc.2001.5098 |
0.113 |
|
2021 |
Bennett TD, Moffitt RA, Hajagos JG, Amor B, Anand A, Bissell MM, Bradwell KR, Bremer C, Byrd JB, Denham A, DeWitt PE, Gabriel D, Garibaldi BT, Girvin AT, Guinney J, ... ... Austin CP, et al. The National COVID Cohort Collaborative: Clinical Characterization and Early Severity Prediction. Medrxiv : the Preprint Server For Health Sciences. PMID 33469592 DOI: 10.1101/2021.01.12.21249511 |
0.113 |
|
2000 |
Bai C, Connolly B, Metzker ML, Hilliard CA, Liu X, Sandig V, Soderman A, Galloway SM, Liu Q, Austin CP, Caskey CT. Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 97: 1230-5. PMID 10655513 DOI: 10.1073/pnas.97.3.1230 |
0.112 |
|
2022 |
Markossian S, Brimacombe KR, Sittampalam GS, Grossman A, Coussens NP, Inglese J, Auld DS, Chin W, Austin CP, Hall MD. The NCATS Assay Guidance Manual programme: advancing the practice and rigour of preclinical translation. Nature Reviews. Drug Discovery. PMID 36253455 DOI: 10.1038/d41573-022-00170-7 |
0.111 |
|
2009 |
Kajiyama H, Titus S, Austin CP, Chiotos K, Matsumoto T, Sakairi T, Kopp JB. Tetracycline-inducible gene expression in conditionally immortalized mouse podocytes. American Journal of Nephrology. 29: 153-63. PMID 18753740 DOI: 10.1159/000151770 |
0.111 |
|
2002 |
Blair IP, Adams LJ, Badenhop RF, Moses MJ, Scimone A, Morris JA, Ma L, Austin CP, Donald JA, Mitchell PB, Schofield PR. A transcript map encompassing a susceptibility locus for bipolar affective disorder on chromosome 4q35. Molecular Psychiatry. 7: 867-73. PMID 12232780 DOI: 10.1038/Sj.Mp.4001113 |
0.106 |
|
2001 |
Zhang K, Kniazeva M, Han M, Li W, Yu Z, Yang Z, Li Y, Metzker ML, Allikmets R, Zack DJ, Kakuk LE, Lagali PS, Wong PW, MacDonald IM, Sieving PA, ... ... Austin CP, et al. A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nature Genetics. 27: 89-93. PMID 11138005 DOI: 10.1038/83817 |
0.104 |
|
2002 |
Van der Ploeg LH, Martin WJ, Howard AD, Nargund RP, Austin CP, Guan X, Drisko J, Cashen D, Sebhat I, Patchett AA, Figueroa DJ, DiLella AG, Connolly BM, Weinberg DH, Tan CP, et al. A role for the melanocortin 4 receptor in sexual function. Proceedings of the National Academy of Sciences of the United States of America. 99: 11381-6. PMID 12172010 DOI: 10.1073/Pnas.172378699 |
0.103 |
|
2000 |
Heise CE, O'Dowd BF, Figueroa DJ, Sawyer N, Nguyen T, Im DS, Stocco R, Bellefeuille JN, Abramovitz M, Cheng R, Williams DL, Zeng Z, Liu Q, Ma L, Clements MK, ... ... Austin CP, et al. Characterization of the human cysteinyl leukotriene 2 receptor. The Journal of Biological Chemistry. 275: 30531-6. PMID 10851239 DOI: 10.1074/Jbc.M003490200 |
0.101 |
|
2001 |
Sailer AW, Sano H, Zeng Z, McDonald TP, Pan J, Pong SS, Feighner SD, Tan CP, Fukami T, Iwaasa H, Hreniuk DL, Morin NR, Sadowski SJ, Ito M, Ito M, ... ... Austin CP, et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proceedings of the National Academy of Sciences of the United States of America. 98: 7564-9. PMID 11404457 DOI: 10.1073/pnas.121170598 |
0.095 |
|
2015 |
Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, et al. The promise and peril of chemical probes. Nature Chemical Biology. 11: 536-41. PMID 26196764 DOI: 10.1038/Nchembio.1867 |
0.095 |
|
2021 |
Bennett TD, Moffitt RA, Hajagos JG, Amor B, Anand A, Bissell MM, Bradwell KR, Bremer C, Byrd JB, Denham A, DeWitt PE, Gabriel D, Garibaldi BT, Girvin AT, Guinney J, ... ... Austin CP, et al. Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative. Jama Network Open. 4: e2116901. PMID 34255046 DOI: 10.1001/jamanetworkopen.2021.16901 |
0.093 |
|
2001 |
Liu Q, Guan XM, Martin WJ, McDonald TP, Clements MK, Jiang Q, Zeng Z, Jacobson M, Williams DL, Yu H, Bomford D, Figueroa D, Mallee J, Wang R, Evans J, ... ... Austin CP, et al. Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception. The Journal of Biological Chemistry. 276: 36961-9. PMID 11481330 DOI: 10.1074/jbc.M105308200 |
0.092 |
|
2000 |
Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, ... ... Austin CP, et al. Identification of receptors for neuromedin U and its role in feeding. Nature. 406: 70-4. PMID 10894543 DOI: 10.1038/35017610 |
0.092 |
|
2003 |
Morris JA, Kandpal G, Ma L, Austin CP. DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Human Molecular Genetics. 12: 1591-608. PMID 12812986 |
0.091 |
|
2016 |
Austin C, Kusumoto F. The application of Big Data in medicine: current implications and future directions. Journal of Interventional Cardiac Electrophysiology : An International Journal of Arrhythmias and Pacing. PMID 26814841 DOI: 10.1007/s10840-016-0104-y |
0.091 |
|
2022 |
Faupel-Badger JM, Vogel AL, Austin CP, Rutter JL. Advancing translational science education. Clinical and Translational Science. PMID 36045637 DOI: 10.1111/cts.13390 |
0.09 |
|
2020 |
Brooks P, Ottinger E, Portero D, Lomash RM, Alimardanov A, Terse P, Xu X, Chandler RJ, Geist Hauserman J, Esposito E, Bönnemann CG, Venditti CP, Austin C, Pariser A, Lo DC. The Platform Vector Gene Therapies (PaVe-GT) Project: Increasing the efficiency of adeno-associated virus (AAV) gene therapy clinical trial startup. Human Gene Therapy. PMID 32993373 DOI: 10.1089/hum.2020.259 |
0.089 |
|
2000 |
Figueroa DJ, Hess JF, Ky B, Brown SD, Sandig V, Hermanowski-Vosatka A, Twells RC, Todd JA, Austin CP. Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 48: 1357-68. PMID 10990489 DOI: 10.1177/002215540004801006 |
0.089 |
|
2015 |
Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, et al. Corrigendum: The promise and peril of chemical probes. Nature Chemical Biology. 11: 887. PMID 26485080 DOI: 10.1038/Nchembio1115-887C |
0.089 |
|
2012 |
Fox JT, Sakamuru S, Huang R, Teneva N, Simmons SO, Xia M, Tice RR, Austin CP, Myung K. Reply to Kojo: Mechanisms of antioxidant-induced DNA damage Proceedings of the National Academy of Sciences of the United States of America. 109: E2029. DOI: 10.1073/Pnas.1207795109 |
0.086 |
|
1999 |
Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature. 399: 789-93. PMID 10391245 DOI: 10.1038/21658 |
0.086 |
|
2016 |
Austin C, Kusumoto F. Innovative pacing: Recent advances, emerging technologies, and future directions in cardiac pacing. Trends in Cardiovascular Medicine. PMID 27017442 DOI: 10.1016/j.tcm.2016.02.006 |
0.085 |
|
2002 |
Ma L, Liu Y, Ky B, Shughrue PJ, Austin CP, Morris JA. Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1). Genomics. 80: 662-72. PMID 12504857 DOI: 10.1006/geno.2002.7012 |
0.085 |
|
2017 |
Austin CP, Dawkins HJS. Medical research: Next decade's goals for rare diseases. Nature. 548: 158. PMID 28796211 DOI: 10.1038/548158c |
0.084 |
|
2016 |
Collins FS, Anderson JM, Austin CP, Battey JF, Birnbaum LS, Briggs JP, Clayton JA, Cuthbert B, Eisinger RW, Fauci AS, Gallin JI, Gibbons GH, Glass RI, Gottesman MM, Gray PA, et al. Basic science: Bedrock of progress. Science (New York, N.Y.). 351: 1405. PMID 27013720 DOI: 10.1126/Science.351.6280.1405-A |
0.083 |
|
2001 |
Figueroa DJ, Breyer RM, Defoe SK, Kargman S, Daugherty BL, Waldburger K, Liu Q, Clements M, Zeng Z, O'Neill GP, Jones TR, Lynch KR, Austin CP, Evans JF. Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes. American Journal of Respiratory and Critical Care Medicine. 163: 226-33. PMID 11208650 DOI: 10.1164/ajrccm.163.1.2003101 |
0.081 |
|
1999 |
Feighner SD, Tan CP, McKee KK, Palyha OC, Hreniuk DL, Pong SS, Austin CP, Figueroa D, MacNeil D, Cascieri MA, Nargund R, Bakshi R, Abramovitz M, Stocco R, Kargman S, et al. Receptor for motilin identified in the human gastrointestinal system. Science (New York, N.Y.). 284: 2184-8. PMID 10381885 DOI: 10.1126/science.284.5423.2184 |
0.08 |
|
2010 |
Terry S, Austin C, Inglese J, Meeker D, Terry P. Assay, preclinical, and clinical brick walls and opportunities for system change through GRANDRx Assay and Drug Development Technologies. 8: 128-134. PMID 20307201 DOI: 10.1089/adt.2010.0802.rt |
0.08 |
|
2010 |
Terry S, Austin C, Inglese J, Meeker D, Terry P. Assay, Preclinical, and Clinical Brick Walls and Opportunities for System Change Through GRANDRx. Assay and Drug Development Technologies. PMID 20233071 DOI: 10.1089/adt.2009.0802.rt |
0.08 |
|
2009 |
Patnaik S, Dietz HC, Zheng W, Austin C, Marugan JJ. Multi-gram scale synthesis of FR180204. The Journal of Organic Chemistry. 74: 8870-3. PMID 19852504 DOI: 10.1021/Jo901835M |
0.079 |
|
2023 |
Taj S, Hussain A, Sanekommu H, Miller B, Austin C, Kilada C, Dandu S, Ahsan E, Erler BS. Metachronous Squamous Cell Carcinoma of the Esophagus After Resolution of Previous Adenocarcinoma. Acg Case Reports Journal. 10: e01097. PMID 37434661 DOI: 10.14309/crj.0000000000001097 |
0.079 |
|
2023 |
Buse JB, Austin CP, Johnston SC, Lewis-Hall F, March AN, Shore CK, Tenaerts P, Rutter JL. A framework for assessing clinical trial site readiness. Journal of Clinical and Translational Science. 7: e151. PMID 37456265 DOI: 10.1017/cts.2023.541 |
0.079 |
|
1995 |
Cepko C, Ryder EF, Austin CP, Walsh C, Fekete DM. Lineage analysis using retrovirus vectors. Methods in Enzymology. 254: 387-419. PMID 8531701 DOI: 10.1016/0076-6879(95)54027-X |
0.076 |
|
2015 |
Colvis CM, Austin CP. The NIH-industry new therapeutic uses pilot program: Demonstrating the power of crowdsourcing Assay and Drug Development Technologies. 13: 297-298. DOI: 10.1089/adt.2015.29006.cmcdrrr |
0.075 |
|
2019 |
Mott MC, Austin CP, Bianchi DW, Cashion AK, Gordon JA, Heemskerk JE, Hodes RJ, Koob GF, Riley WT, Sieving PA, Shurtleff D, Somerman MJ, Volkow ND, Anderson KC, Owens DF, et al. The NIH Blueprint for Neuroscience Research Seeks Community Input on Future Neuroscience Investments. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 39: 774-775. PMID 30700523 DOI: 10.1523/Jneurosci.2742-18.2018 |
0.074 |
|
2022 |
Austin CP, Odak M, Douedi S, Patel SV. Supraventricular Tachycardia: An Atypical Presentation of Thyroid Storm. Cureus. 14: e25449. PMID 35774700 DOI: 10.7759/cureus.25449 |
0.073 |
|
2022 |
Amin T, Austin CP, Udongwo N, Wiseman K, Parhar AS, Chaughtai S. Iodinated Contrast-Induced Thyroid Storm With Concomitant Cardiac Tamponade: A Case Report. Cureus. 14: e28001. PMID 36134087 DOI: 10.7759/cureus.28001 |
0.072 |
|
2004 |
Austin CP, Ky B, Ma L, Morris JA, Shughrue PJ. Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development. Neuroscience. 124: 3-10. PMID 14960334 DOI: 10.1016/j.neuroscience.2003.11.010 |
0.071 |
|
2007 |
Gerhold D, Bagchi A, Lu M, Figueroa D, Keenan K, Holder D, Wang Y, Jin H, Connolly B, Austin C, Alonso-Galicia M. Androgens drive divergent responses to salt stress in male versus female rat kidneys. Genomics. 89: 731-44. PMID 17481853 DOI: 10.1016/j.ygeno.2007.01.009 |
0.07 |
|
2021 |
Herstein JJ, Degarege A, Stover D, Austin C, Schwedhelm MM, Lawler JV, Lowe JJ, Ramos AK, Donahue M. Characteristics of SARS-CoV-2 Transmission among Meat Processing Workers in Nebraska, USA, and Effectiveness of Risk Mitigation Measures. Emerging Infectious Diseases. 27. PMID 33591249 DOI: 10.3201/eid2704.204800 |
0.068 |
|
1993 |
Green AI, Austin CP. Psychopathology of pancreatic cancer. A psychobiologic probe. Psychosomatics. 34: 208-21. PMID 8493302 DOI: 10.1016/S0033-3182(93)71882-4 |
0.067 |
|
2018 |
Austin C, Kusumoto F. Updates in medical professional liability: a primer for electrophysiologists. Journal of Interventional Cardiac Electrophysiology : An International Journal of Arrhythmias and Pacing. PMID 30276591 DOI: 10.1007/s10840-018-0453-9 |
0.065 |
|
2020 |
Zhang X, Kurilla MG, Austin CP. The CTSA program's role in improving rural public health: Community-engaged disease prevention and health care innovation. Journal of Clinical and Translational Science. 4: 373-376. PMID 33244424 DOI: 10.1017/cts.2020.541 |
0.064 |
|
2008 |
Patel S, Novikova N, Beenders B, Austin C, Bellini M. Live images of RNA polymerase II transcription units Chromosome Research. 16: 223-232. PMID 18320360 DOI: 10.1007/S10577-007-1189-Z |
0.063 |
|
2009 |
Birney E, Hudson TJ, Green ED, Gunter C, Eddy S, Rogers J, Harris JR, Ehrlich SD, Apweiler R, Austin CP, Berglund L, Bobrow M, Bountra C, Brookes AJ, et al. Prepublication data sharing. Nature. 461: 168-70. PMID 19741685 DOI: 10.1038/461168A |
0.063 |
|
2009 |
Kavlock RJ, Austin CP, Tice RR. Toxicity testing in the 21st century: implications for human health risk assessment. Risk Analysis : An Official Publication of the Society For Risk Analysis. 29: 485-7; discussion 49. PMID 19076321 DOI: 10.1111/j.1539-6924.2008.01168.x |
0.06 |
|
2021 |
Livingstone KM, Tan MH, Abbott G, Duckham RL, Croft L, Ward J, McEvoy M, Keske MA, Austin C, Bowe SJ. Discovery Genome-Wide Association Study of Body Composition in 4,386 Adults From the UK Biobank's Pilot Imaging Enhancement Study. Frontiers in Endocrinology. 12: 692677. PMID 34239500 DOI: 10.3389/fendo.2021.692677 |
0.059 |
|
2003 |
Shughrue PJ, Ky B, Austin CP. Localization of B1 bradykinin receptor mRNA in the primate brain and spinal cord: an in situ hybridization study. The Journal of Comparative Neurology. 465: 372-84. PMID 12966562 DOI: 10.1002/cne.10846 |
0.058 |
|
2012 |
Williams JB, Mallorga PJ, Lemaire W, Williams DL, Na S, Patel S, Jeffrey Conn P, Pettibone DJ, Austin C, Sura C. Corrigendum to “Development of a scintillation proximity assay for analysis of Na+/Cl− -dependent neurotransmitter transporter activity” [Anal. Biochem. 321 (2003) 31–37] Analytical Biochemistry. 429: 18. DOI: 10.1016/j.ab.2012.01.024 |
0.057 |
|
2012 |
Anastasiou D, Yu Y, Israelsen WJ, Jiang J, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, ... ... Austin CP, et al. Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis Nature Chemical Biology. 8: 1008-1008. DOI: 10.1038/Nchembio1212-1008B |
0.057 |
|
2018 |
Ray JC, Burger C, Mergo P, Safford R, Blackshear J, Austin C, Fairweather D, Heckman MG, Zeiger T, Dubin M, Shapiro B. Pulmonary arterial stiffness assessed by cardiovascular magnetic resonance imaging is a predictor of mild pulmonary arterial hypertension. The International Journal of Cardiovascular Imaging. PMID 29934885 DOI: 10.1007/s10554-018-1397-y |
0.054 |
|
2009 |
Austin C, Novikova N, Guacci V, Bellini M. Lampbrush chromosomes enable study of cohesin dynamics. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 17: 165-84. PMID 19308699 DOI: 10.1007/s10577-008-9015-9 |
0.054 |
|
2000 |
Uebele VN, Lagrutta A, Wade T, Figueroa DJ, Liu Y, McKenna E, Austin CP, Bennett PB, Swanson R. Cloning and functional expression of two families of beta-subunits of the large conductance calcium-activated K+ channel. The Journal of Biological Chemistry. 275: 23211-8. PMID 10766764 DOI: 10.1074/jbc.M910187199 |
0.052 |
|
2022 |
Taj S, Austin CP, Ahmed Z, Fareen N, Chaughtai Z, Pervaiz H, Chaughtai S. Lemierre's Syndrome: A Comeback Story. Cureus. 14: e25843. PMID 35832767 DOI: 10.7759/cureus.25843 |
0.051 |
|
2002 |
Blair IP, Adam LJ, Badenhop RF, Moses MJ, Scimone A, Morris JA, Ma L, Austin CP, Donald JA, Mitchell PB, Schofield PR. Stylized transcript map of chromosome 4q35 encompassing the locus for a bipolar disorder susceptibility gene. Molecular Psychiatry. 7: 669. PMID 12192607 DOI: 10.1038/Sj.Mp.4001154 |
0.051 |
|
2013 |
Xu M, Liu K, Swaroop M, Porter FD, Sidhu R, Firnkes S, Ory DS, Marugan JJ, Xiao J, Southall N, Pavan WJ, Davidson C, Walkley SU, Remaley AT, Baxa U, ... ... Austin CP, et al. δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders (Journal of Biological Chemistry (2012) 287, (39349-39360)) Journal of Biological Chemistry. 288: 296. DOI: 10.1074/Jbc.A112.357707 |
0.05 |
|
2007 |
Simeonov A, Yasgar A, Klumpp C, Zheng W, Shafqat N, Oppermann U, Austin CP, Inglese J. Evaluation of micro-parallel liquid chromatography as a method for HTS-coupled actives verification. Assay and Drug Development Technologies. 5: 815-24. PMID 18078381 DOI: 10.1089/adt.2007.097 |
0.048 |
|
2017 |
Austin C, Burger C, Kane G, Safford R, Blackshear J, Ung R, Ray J, Alsaad A, Alassas K, Shapiro B. High-risk echocardiographic features predict mortality in pulmonary arterial hypertension. American Heart Journal. 189: 167-176. PMID 28625373 DOI: 10.1016/j.ahj.2017.04.013 |
0.047 |
|
2003 |
Zeng Z, McDonald TP, Wang R, Liu Q, Austin CP. Neuropeptide FF receptor 2 (NPFF2) is localized to pain-processing regions in the primate spinal cord and the lower level of the medulla oblongata. Journal of Chemical Neuroanatomy. 25: 269-78. PMID 12842272 |
0.046 |
|
2021 |
Austin CP. Translational misconceptions. Nature Reviews. Drug Discovery. PMID 33462425 DOI: 10.1038/d41573-021-00008-8 |
0.046 |
|
2018 |
Austin CP. Translating translation. Nature Reviews. Drug Discovery. PMID 29674698 DOI: 10.1038/nrd.2018.27 |
0.045 |
|
1999 |
Austin CP, Holder DJ, Ma L, Mixson LA, Caskey CT. Mapping of hKCa3 to chromosome 1q21 and investigation of linkage of CAG repeat polymorphism to schizophrenia. Molecular Psychiatry. 4: 261-6. PMID 10395216 |
0.044 |
|
2000 |
Liu Y, McKenna E, Figueroa DJ, Blevins R, Austin CP, Bennett PB, Swanson R. The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas. Cytogenetics and Cell Genetics. 90: 60-3. PMID 11060447 |
0.044 |
|
2001 |
DiLella AG, Toner TJ, Austin CP, Connolly BM. Identification of genes differentially expressed in benign prostatic hyperplasia. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 49: 669-70. PMID 11304808 |
0.044 |
|
2022 |
Haines DE, Austin C, Kusumoto FM, Liu CH, Mounsey JP, Proto-Conroy K, Selzman KA. Heart Rhythm Society Policy Statement Update: Recommendations on the role of industry-employed allied professionals. Heart Rhythm. 20: 157-162. PMID 37264874 DOI: 10.1016/j.hrthm.2022.08.029 |
0.041 |
|
2004 |
Yan L, Figueroa DJ, Austin CP, Liu Y, Bugianesi RM, Slaughter RS, Kaczorowski GJ, Kohler MG. Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes. 53: 597-607. PMID 14988243 |
0.041 |
|
2018 |
Rodgers G, Austin C, Anderson J, Pawlyk A, Colvis C, Margolis R, Baker J. Glimmers in illuminating the druggable genome. Nature Reviews. Drug Discovery. PMID 29348682 DOI: 10.1038/nrd.2017.252 |
0.04 |
|
2001 |
Figueroa DJ, Shi XP, Gardell SJ, Austin CP. Abetapp secretases are co-expressed with Abetapp in the pancreatic islets. Journal of Alzheimer's Disease : Jad. 3: 393-396. PMID 12214042 DOI: 10.3233/JAD-2001-3405 |
0.038 |
|
2003 |
Austin CP, Ma L, Ky B, Morris JA, Shughrue PJ. DISC1 (Disrupted in Schizophrenia-1) is expressed in limbic regions of the primate brain. Neuroreport. 14: 951-4. PMID 12802181 DOI: 10.1097/01.wnr.0000074342.81633.63 |
0.037 |
|
2023 |
Taj S, Mujtaba M, Miller B, Dandu S, Austin CP, Ali Akbar U, Sanekommu H, Hossain MA. Role of Plasmapheresis in Hemolysis, Elevated Liver Enzymes and Low Platelets (HELLP) Syndrome. Cureus. 15: e35520. PMID 37007368 DOI: 10.7759/cureus.35520 |
0.032 |
|
2019 |
Tanaka ST, Paramsothy P, Thibadeau J, Wiener JS, Joseph DB, Cheng EY, Tu D, Austin C, Koh CJ, Wallis MC, Walker WO, Smith KA, Routh JC, Baum MA. Baseline Urinary Imaging in Infants Enrolled in Urologic Management to Preserve Initial Renal Function (UMPIRE) Protocol for Children with Spina Bifida. The Journal of Urology. PMID 30730412 DOI: 10.1097/JU.0000000000000141 |
0.027 |
|
2024 |
Deering TF, Catanzaro JN, Sandhu RK, Singleton M, Das S, Deyell MW, Mulpuru SK, Magnelli-Reyes CL, Koplan BA, Vergara GR, Austin C, Assis FR, Xiang K, Moore M, Smith AM. Heart Rhythm Society Quality Improvement Committee update. Heart Rhythm. 21: 241-243. PMID 38296459 DOI: 10.1016/j.hrthm.2023.11.014 |
0.027 |
|
2021 |
Austin CP, Jonson S, Kurilla MG. Foreword to the JCTS COVID-19 special issue. Journal of Clinical and Translational Science. 5: e103. PMID 34164155 DOI: 10.1017/cts.2021.400 |
0.026 |
|
2021 |
Goel R, Winchester DE, Austin C, Staples ED. Pneumopericardium Develops After Pacemaker Implantation. Texas Heart Institute Journal. 48. PMID 34665870 DOI: 10.14503/THIJ-19-7093 |
0.025 |
|
2013 |
Batton K, Moussa I, Blackshear J, Mergo P, Austin C, Shapiro B. Use of cardiac magnetic resonance imaging for alcohol septal ablation in hypertrophic obstructive cardiomyopathy. Acute Cardiac Care. 15: 44-6. PMID 23663012 DOI: 10.3109/17482941.2013.781188 |
0.024 |
|
2015 |
Austin C, Alassas K, Burger C, Safford R, Pagan R, Duello K, Kumar P, Zeiger T, Shapiro B. Echocardiographic assessment of estimated right atrial pressure and size predicts mortality in pulmonary arterial hypertension. Chest. 147: 198-208. PMID 25211049 DOI: 10.1378/chest.13-3035 |
0.02 |
|
2010 |
Austin C. Editorial Comment Urology. 75: 169. PMID 20109716 DOI: 10.1016/j.urology.2009.07.1269 |
0.013 |
|
2021 |
Jones P, Rajasegaran A, Brassale S, Chen Y, Haslam R, Austin C, Seideman CA. Assessment of the Educational Value of Distal Hypospadias Repair Videos on YouTube. Urology. PMID 34461144 DOI: 10.1016/j.urology.2021.08.020 |
0.012 |
|
2020 |
Galson S, Austin CP, Khandekar E, Hudson LD, DiMasi JA, Califf R, Wagner JA. The failure to fail smartly. Nature Reviews. Drug Discovery. PMID 32968225 DOI: 10.1038/d41573-020-00167-0 |
0.01 |
|
1991 |
Austin CP, Lessell S. Horner's syndrome from hypothalamic infarction. Archives of Neurology. 48: 332-4. PMID 2001193 |
0.01 |
|
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