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Joshua M. Korn, Ph.D. - Publications

Affiliations: 
2010 Harvard University, Cambridge, MA, United States 
Area:
structural biology
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48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Palmer AC, Plana D, Gao H, Korn JM, Yang G, Green J, Zhang X, Velazquez R, McLaughlin ME, Ruddy DA, Kowal C, Goldovitz J, Bullock C, Rivera S, Rakiec DP, et al. A proof of concept for biomarker-guided targeted therapy against ovarian cancer based on patient-derived tumor xenografts. Cancer Research. PMID 32747364 DOI: 10.1158/0008-5472.Can-19-3850  0.372
2020 Ye LF, Reznik E, Korn JM, Lin F, Yang G, Malesky K, Gao H, Loo A, Pagliarini R, Mikkelsen T, Lo DC, deCarvalho AC, Stockwell BR. Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery. Oncotarget. 11: 443-451. PMID 32064048 DOI: 10.18632/Oncotarget.27457  0.372
2019 Raoof S, Mulford IJ, Frisco-Cabanos H, Nangia V, Timonina D, Labrot E, Hafeez N, Bilton SJ, Drier Y, Ji F, Greenberg M, Williams A, Kattermann K, Damon L, Sovath S, ... ... Korn JM, et al. Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer. Oncogene. PMID 31324888 DOI: 10.1038/S41388-019-0887-2  0.391
2019 Ghandi M, Huang FW, Jané-Valbuena J, Kryukov GV, Lo CC, McDonald ER, Barretina J, Gelfand ET, Bielski CM, Li H, Hu K, Andreev-Drakhlin AY, Kim J, Hess JM, Haas BJ, ... ... Korn JM, et al. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature. PMID 31068700 DOI: 10.1038/S41586-019-1186-3  0.393
2019 Bhang HC, DiMare MT, Kodack DP, Tan L, Kerr G, Radhakrishna VK, Golji J, Ruddy DA, Yuan T, Niederst MJ, Korn JM, Porta DG, Hammerman PS, Engelman JA, Abrams T, et al. Abstract 394: In vivo shRNA screens under treatment pressure by BRAF and MEK inhibitors to identify novel combination treatment strategies for BRAF-mutant colorectal cancer Cancer Research. 79: 394-394. DOI: 10.1158/1538-7445.Sabcs18-394  0.381
2019 Cotton JL, KrishnamurthyRadhakrishna V, Chen J, Piquet M, Wagner J, Boulay G, Sprouffske K, Song Y, Li X, Schumacher K, Thierry R, Kirkpatrick ND, Ruddy DA, Korn J, Morris EJ, et al. Abstract A122: Molecular barcoding and single cell approaches to investigate drug tolerance in EGFRmut NSCLC Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-A122  0.376
2018 Liu H, Golji J, Brodeur LK, Chung FS, Chen JT, deBeaumont RS, Bullock CP, Jones MD, Kerr G, Li L, Rakiec DP, Schlabach MR, Sovath S, Growney JD, Pagliarini RA, ... ... Korn JM, et al. Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss. Nature Medicine. PMID 30559422 DOI: 10.1038/S41591-018-0302-5  0.361
2018 de Weck A, Golji J, Jones MD, Korn JM, Billy E, McDonald ER, Schmelzle T, Bitter H, Kauffmann A. Correction of copy number induced false positives in CRISPR screens. Plos Computational Biology. 14: e1006279. PMID 30024886 DOI: 10.1371/Journal.Pcbi.1006279  0.33
2018 Shao W, Mishina Y, Feng Y, Caponigro G, Cooke VG, Rivera S, Wang Y, Shen F, Korn JM, Mathews Griner L, Nishiguchi G, Rico A, Tellew J, Haling J, Aversa R, et al. Antitumor properties of RAF709, a highly selective and potent inhibitor of RAF kinase dimers, in tumors driven by mutant RAS or BRAF. Cancer Research. PMID 29343524 DOI: 10.1158/0008-5472.Can-17-2033  0.348
2018 Stuart DD, Shao W, Mishina Y, Feng Y, Caponigro G, Cooke VG, Rivera S, Shen F, Korn J, Griner LAM, Nishiguchi G, Taft B, Wan L, Subramanian S, Lou Y, et al. Abstract DDT01-04: Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Ddt01-04  0.377
2017 McDonald ER, de Weck A, Schlabach MR, Billy E, Mavrakis KJ, Hoffman GR, Belur D, Castelletti D, Frias E, Gampa K, Golji J, Kao I, Li L, Megel P, Perkins TA, ... ... Korn J, et al. Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening. Cell. 170: 577-592.e10. PMID 28753431 DOI: 10.1016/J.Cell.2017.07.005  0.397
2017 Emery CM, Monaco KA, Wang P, Balak MN, Freeman A, Meltzer J, Delach S, Rakiec D, Ruddy DA, Korn JM, Haling J, Acker MG, Caponigro G. BRAF-inhibitor associated MEK Mutations Increase RAF-dependent and-independent Enzymatic Activity. Molecular Cancer Research : McR. PMID 28655712 DOI: 10.1158/1541-7786.Mcr-17-0211  0.392
2016 Munoz DM, Cassiani PJ, Li L, Billy E, Korn JM, Jones MD, Golji J, Ruddy DA, Yu K, McAllister G, DeWeck A, Abramowski D, Wan J, Shirley MD, Neshat SY, et al. CRISPR screens provide a comprehensive assessment of cancer vulnerabilities but generate false-positive hits for highly amplified genomic regions. Cancer Discovery. PMID 27260157 DOI: 10.1158/2159-8290.Cd-16-0178  0.377
2016 Mounir Z, Korn JM, Westerling T, Lin F, Kirby CA, Schirle M, McAllister G, Hoffman G, Ramadan N, Hartung A, Feng Y, Kipp DR, Quinn C, Fodor M, Baird J, et al. ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the androgen receptor. Elife. 5. PMID 27183006 DOI: 10.7554/Elife.13964  0.308
2015 Lantermann AB, Chen D, McCutcheon KJ, Hoffman GR, Frias E, Ruddy DA, Rakiec DP, Korn JM, McAllister G, Stegmeier F, Meyer MJ, Sharma SV. Inhibition of casein kinase 1 alpha prevents acquired drug resistance to erlotinib in EGFR-mutant non-small cell lung cancer. Cancer Research. PMID 26490646 DOI: 10.1158/0008-5472.Can-15-1113  0.364
2015 Gao H, Korn JM, Ferretti S, Monahan JE, Wang Y, Singh M, Zhang C, Schnell C, Yang G, Zhang Y, Balbin OA, Barbe S, Cai H, Casey F, Chatterjee S, et al. High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response. Nature Medicine. PMID 26479923 DOI: 10.1038/Nm.3954  0.357
2015 Reddy A, Growney JD, Wilson NS, Emery CM, Johnson JA, Ward R, Monaco KA, Korn J, Monahan JE, Stump MD, Mapa FA, Wilson CJ, Steiger J, Ledell J, Rickles RJ, et al. Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages. Plos One. 10: e0138486. PMID 26378449 DOI: 10.1371/Journal.Pone.0138486  0.338
2015 Gibaja V, Shen F, Harari J, Korn J, Ruddy D, Saenz-Vash V, Zhai H, Rejtar T, Paris CG, Yu Z, Lira M, King D, Qi W, Keen N, Hassan AQ, et al. Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors. Oncogene. PMID 25893294 DOI: 10.1038/Onc.2015.114  0.383
2015 Bhang HE, Ruddy DA, Krishnamurthy Radhakrishna V, Caushi JX, Zhao R, Hims MM, Singh AP, Kao I, Rakiec D, Shaw P, Balak M, Raza A, Ackley E, Keen N, Schlabach MR, ... ... Korn JM, et al. Studying clonal dynamics in response to cancer therapy using high-complexity barcoding. Nature Medicine. 21: 440-8. PMID 25849130 DOI: 10.1038/Nm.3841  0.372
2015 Mounir Z, Lin F, Lin VG, Korn JM, Yu Y, Valdez R, Aina OH, Buchwalter G, Jaffe AB, Korpal M, Zhu P, Brown M, Cardiff RD, Rocnik JL, Yang Y, et al. TMPRSS2:ERG blocks neuroendocrine and luminal cell differentiation to maintain prostate cancer proliferation. Oncogene. 34: 3815-25. PMID 25263440 DOI: 10.1038/Onc.2014.308  0.344
2015 Balbin A, Singh A, Korn J, Gao H, Stuart D, Green J, Crenshaw A, Mahan S, Houde N, Raza A, Leary R, Chiang D, Morrissey M, Winckler W, William S. Abstract B36: Modeling genetic mechanisms of resistance in melanoma primary tumor xenografts Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Pms14-B36  0.425
2015 Caushi JX, Bhang HC, Li J, Kao I, Radhakrishna VK, Cooke VG, Korn JM, Ruddy DA, Kasibhatla S, Stegmeier F. Abstract 3240: Understanding clonal complexity of a tumor xenograft model via cellular barcoding technology Cancer Research. 75: 3240-3240. DOI: 10.1158/1538-7445.Am2015-3240  0.392
2015 Bhang HC, Ruddy DA, Radhakrishna VK, Zhao R, Kao I, Rakiec D, Shaw P, Balak M, Caushi JX, Ackley E, Keen N, Schlabach MR, Palmer M, Sellers WR, Michor F, ... ... Korn JM, et al. Abstract 2847: High complexity barcoding to study clonal dynamics in response to cancer therapy Cancer Research. 75: 2847-2847. DOI: 10.1158/1538-7445.Am2015-2847  0.392
2015 Reddy A, Pinzon-Ortiz M, Derti A, Korn J, Ruddy D, Yang G, Green J, Gao H, Lehar J, Caponigro G, Cao ZA. Abstract 2692: High allele frequency of KRAS functional mutations predicts resistance to MEK inhibitors: Evidence from cell lines and human tumor xenograft models Cancer Research. 75: 2692-2692. DOI: 10.1158/1538-7445.Am2015-2692  0.418
2014 Schoumacher M, Hurov KE, Lehár J, Yan-Neale Y, Mishina Y, Sonkin D, Korn JM, Flemming D, Jones MD, Antonakos B, Cooke VG, Steiger J, Ledell J, Stump MD, Sellers WR, et al. Inhibiting Tankyrases sensitizes KRAS-mutant cancer cells to MEK inhibitors via FGFR2 feedback signaling. Cancer Research. 74: 3294-305. PMID 24747911 DOI: 10.1158/0008-5472.Can-14-0138-T  0.404
2014 Rahal R, Frick M, Romero R, Korn JM, Kridel R, Chan FC, Meissner B, Bhang HE, Ruddy D, Kauffmann A, Farsidjani A, Derti A, Rakiec D, Naylor T, Pfister E, et al. Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma. Nature Medicine. 20: 87-92. PMID 24362935 DOI: 10.1038/Nm.3435  0.321
2014 Shao W, Schoumacher M, Hurov K, Lehar J, Yan-Neale Y, Mishina Y, Sonkin D, Korn J, Flemming D, Jones M, Antonakos B, Cooke V, Stump M, Danial N, Sellers W. Abstract LB-107: Inhibiting TNKS sensitizes KRAS mutant cancer cells to MEK inhibitors by suppressing FGFR2 feedback signaling Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-107  0.395
2013 Korpal M, Korn JM, Gao X, Rakiec DP, Ruddy DA, Doshi S, Yuan J, Kovats SG, Kim S, Cooke VG, Monahan JE, Stegmeier F, Roberts TM, Sellers WR, Zhou W, et al. An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide). Cancer Discovery. 3: 1030-43. PMID 23842682 DOI: 10.1158/2159-8290.Cd-13-0142  0.381
2013 Chen Y, Chen J, Loo A, Jaeger S, Bagdasarian L, Yu J, Chung F, Korn J, Ruddy D, Guo R, McLaughlin ME, Feng F, Zhu P, Stegmeier F, Pagliarini R, et al. Targeting HSF1 sensitizes cancer cells to HSP90 inhibition. Oncotarget. 4: 816-29. PMID 23615731 DOI: 10.18632/Oncotarget.991  0.337
2013 Barrett R, Guo R, Yuan J, Cooke V, Vattay A, Korn J, Liang G, Li X, Thiruvamoor R, Wylie A, Bric A, Keen N, Sellers W. Abstract C149: The PKC inhibitor Sotrastaurin selectively inhibits the growth of GNAQ mutant uveal melanoma. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C149  0.347
2013 Yang G, Green J, Kowal C, Cogan S, Velazquez R, Monahan J, Korn J, Keen N, Williams J, Gao H. Abstract A11: Modeling drug response and resistance using patient-derived xenograft models. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-A11  0.394
2012 Grassian AR, Lin F, Barrett R, Liu Y, Jiang W, Korpal M, Astley H, Gitterman D, Henley T, Howes R, Levell J, Korn JM, Pagliarini R. Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT). The Journal of Biological Chemistry. 287: 42180-94. PMID 23038259 DOI: 10.1074/Jbc.M112.417832  0.332
2012 Flannick J, Korn JM, Fontanillas P, Grant GB, Banks E, Depristo MA, Altshuler D. Efficiency and power as a function of sequence coverage, SNP array density, and imputation. Plos Computational Biology. 8: e1002604. PMID 22807667 DOI: 10.1371/Journal.Pcbi.1002604  0.33
2011 Rivas MA, Beaudoin M, Gardet A, Stevens C, Sharma Y, Zhang CK, Boucher G, Ripke S, Ellinghaus D, Burtt N, Fennell T, Kirby A, Latiano A, Goyette P, Green T, ... ... Korn JM, et al. Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nature Genetics. 43: 1066-73. PMID 21983784 DOI: 10.1038/Ng.952  0.347
2011 Im KM, Kirchhoff T, Wang X, Green T, Chow CY, Vijai J, Korn J, Gaudet MM, Fredericksen Z, Shane Pankratz V, Guiducci C, Crenshaw A, McGuffog L, Kartsonaki C, Morrison J, et al. Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers. Human Genetics. 130: 685-99. PMID 21597964 DOI: 10.1007/S00439-011-1003-Z  0.36
2011 Chiang CW, Gajdos ZK, Korn JM, Butler JL, Hackett R, Guiducci C, Nguyen TT, Wilks R, Forrester T, Henderson KD, Le Marchand L, Henderson BE, Haiman CA, Cooper RS, Lyon HN, et al. The efficacy of detecting variants with small effects on the Affymetrix 6.0 platform using pooled DNA. Human Genetics. 130: 607-21. PMID 21424828 DOI: 10.1007/S00439-011-0974-0  0.339
2011 Handsaker RE, Korn JM, Nemesh J, McCarroll SA. Discovery and genotyping of genome structural polymorphism by sequencing on a population scale. Nature Genetics. 43: 269-76. PMID 21317889 DOI: 10.1038/Ng.768  0.312
2011 Mills RE, Walter K, Stewart C, Handsaker RE, Chen K, Alkan C, Abyzov A, Yoon SC, Ye K, Cheetham RK, Chinwalla A, Conrad DF, Fu Y, Grubert F, Hajirasouliha I, ... ... Korn J, et al. Mapping copy number variation by population-scale genome sequencing. Nature. 470: 59-65. PMID 21293372 DOI: 10.1038/Nature09708  0.331
2010 Gaudet MM, Kirchhoff T, Green T, Vijai J, Korn JM, Guiducci C, Segrè AV, McGee K, McGuffog L, Kartsonaki C, Morrison J, Healey S, Sinilnikova OM, Stoppa-Lyonnet D, Mazoyer S, et al. Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. Plos Genetics. 6: e1001183. PMID 21060860 DOI: 10.1371/Journal.Pgen.1001183  0.365
2010 Altshuler DM, Gibbs RA, Peltonen L, Altshuler DM, Gibbs RA, Peltonen L, Dermitzakis E, Schaffner SF, Yu F, Peltonen L, Dermitzakis E, Bonnen PE, Altshuler DM, Gibbs RA, ... ... Korn JM, et al. Integrating common and rare genetic variation in diverse human populations. Nature. 467: 52-8. PMID 20811451 DOI: 10.1038/Nature09298  0.352
2010 Chiang CW, Gajdos ZK, Korn JM, Kuruvilla FG, Butler JL, Hackett R, Guiducci C, Nguyen TT, Wilks R, Forrester T, Haiman CA, Henderson KD, Le Marchand L, Henderson BE, Palmert MR, et al. Rapid assessment of genetic ancestry in populations of unknown origin by genome-wide genotyping of pooled samples. Plos Genetics. 6: e1000866. PMID 20221249 DOI: 10.1371/Journal.Pgen.1000866  0.328
2010 Gaudet MM, Kirchhoff T, Green T, Vijai J, Korn JM, Guiducci C, Segrè AV, McGee K, McGuffog L, Kartsonaki C, Morrison J, Healey S, Sinilnikova OM, Stoppa-Lyonnet D, Mazoyer S, et al. Correction: Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer Plos Genetics. 6. DOI: 10.1371/Annotation/B28Cf02D-7196-4A16-8B36-6562A0B84F75  0.311
2009 Weiss LA, Arking DE, Daly MJ, Chakravarti A, Brune CW, West K, O'Connor A, Hilton G, Tomlinson RL, West AB, Cook EH, Green T, Chang SC, Gabriel S, Gates C, ... ... Korn J, et al. A genome-wide linkage and association scan reveals novel loci for autism Nature. 461: 802-808. PMID 19812673 DOI: 10.1038/Nature08490  0.378
2009 Greenway SC, Pereira AC, Lin JC, DePalma SR, Israel SJ, Mesquita SM, Ergul E, Conta JH, Korn JM, McCarroll SA, Gorham JM, Gabriel S, Altshuler DM, Quintanilla-Dieck Mde L, Artunduaga MA, et al. De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nature Genetics. 41: 931-5. PMID 19597493 DOI: 10.1038/Ng.415  0.34
2009 Kathiresan S, Voight BF, Purcell S, Musunuru K, Ardissino D, Mannucci PM, Anand S, Engert JC, Samani NJ, Schunkert H, Erdmann J, Reilly MP, Rader DJ, Morgan T, ... ... Korn JM, et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nature Genetics. 41: 334-41. PMID 19198609 DOI: 10.1038/Ng.327  0.328
2008 Korn JM, Kuruvilla FG, McCarroll SA, Wysoker A, Nemesh J, Cawley S, Hubbell E, Veitch J, Collins PJ, Darvishi K, Lee C, Nizzari MM, Gabriel SB, Purcell S, Daly MJ, et al. Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs. Nature Genetics. 40: 1253-60. PMID 18776909 DOI: 10.1038/Ng.237  0.325
2008 McCarroll SA, Kuruvilla FG, Korn JM, Cawley S, Nemesh J, Wysoker A, Shapero MH, de Bakker PI, Maller JB, Kirby A, Elliott AL, Parkin M, Hubbell E, Webster T, Mei R, et al. Integrated detection and population-genetic analysis of SNPs and copy number variation. Nature Genetics. 40: 1166-74. PMID 18776908 DOI: 10.1038/Ng.238  0.357
2008 Kidd JM, Cooper GM, Donahue WF, Hayden HS, Sampas N, Graves T, Hansen N, Teague B, Alkan C, Antonacci F, Haugen E, Zerr T, Yamada NA, Tsang P, Newman TL, ... ... Korn JM, et al. Mapping and sequencing of structural variation from eight human genomes. Nature. 453: 56-64. PMID 18451855 DOI: 10.1038/Nature06862  0.327
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