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Paul T. Wilder, Ph.D. - Publications

Affiliations: 
2004 University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
structure and function of S100B, a growth factor in the brain and skin
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60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Chen L, Chan AM, Wilder PT, Fletcher S. 1-Sulfonylated 1,2,3,4-tetrahydroquinoline-6-carboxylic acids as simple, readily-accessible MCL-1 inhibitors. Drug Development Research. PMID 36281026 DOI: 10.1002/ddr.22004  0.31
2021 Young BD, Varney KM, Wilder PT, Costabile BK, Pozharski E, Cook ME, Godoy-Ruiz R, Clarke OB, Mancia F, Weber DJ. Physiologically Relevant Free Ca Ion Concentrations Regulate STRA6-Calmodulin Complex Formation via the BP2 Region of STRA6. Journal of Molecular Biology. 433: 167272. PMID 34592217 DOI: 10.1016/j.jmb.2021.167272  0.742
2021 Alasady MJ, Terry AR, Pierce AD, Cavalier MC, Blaha CS, Adipietro KA, Wilder PT, Weber DJ, Hay N. The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling. Plos One. 16: e0256238. PMID 34411141 DOI: 10.1371/journal.pone.0256238  0.779
2020 Conlon IL, Drennen B, Lanning ME, Hughes S, Rothhaas R, Wilder PT, MacKerell AD, Fletcher S. Rationally Designed Polypharmacology: α-Helix Mimetics as Dual Inhibitors of the Oncoproteins Mcl-1 and HDM2. Chemmedchem. PMID 32583936 DOI: 10.1002/Cmdc.202000278  0.378
2020 Varney KM, Wilder PT, Godoy-Ruiz R, Mancia F, Weber DJ. Correction to: H, C, and N resonance assignments of human calmodulin bound to a peptide derived from the STRA6 vitamin A transporter (CaMBP2). Biomolecular Nmr Assignments. PMID 32248334 DOI: 10.1007/s12104-020-09942-x  0.646
2020 Xu X, Godoy-Ruiz R, Adipietro KA, Peralta C, Ben-Hail D, Varney KM, Cook ME, Roth BM, Wilder PT, Cleveland T, Grishaev A, Neu HM, Michel SLJ, Yu W, Beckett D, et al. Structure of the cell-binding component of the binary toxin reveals a di-heptamer macromolecular assembly. Proceedings of the National Academy of Sciences of the United States of America. PMID 31896582 DOI: 10.1073/Pnas.1919490117  0.803
2020 Costabile BK, Chen Y, Kim J, Kim Y, Clarke OB, Wilder PT, Weber DJ, Quadro L, Sun H, Mancia F. Investigating the Mechanism of STRA6-Mediated Cellular Retinol Uptake Biophysical Journal. 118: 93a. DOI: 10.1016/J.Bpj.2019.11.672  0.409
2020 Coburn K, Solano-Gonzalez E, Roth B, Wilder PT, Varney K, Carrier F, Weber DJ. Investigation of the Impact of Post-Translational Modifications of HNRNP A18 on Small Molecule Inhibitors Biophysical Journal. 118: 49a. DOI: 10.1016/J.Bpj.2019.11.450  0.761
2019 Donohue E, Khorsand S, Mercado G, Varney KM, Wilder PT, Yu W, MacKerell AD, Alexander P, Van QN, Moree B, Stephen AG, Weber DJ, Salafsky J, McCormick F. Second harmonic generation detection of Ras conformational changes and discovery of a small molecule binder. Proceedings of the National Academy of Sciences of the United States of America. PMID 31399543 DOI: 10.1073/Pnas.1905516116  0.727
2019 Bester SM, Adipietro KA, Funk VL, Myslinski J, Keul ND, Cheung J, Wilder PT, Wood ZA, Weber DJ, Height JJ, Pegan SD. The structural and biochemical impact of monomerizing human acetylcholinesterase. Protein Science : a Publication of the Protein Society. PMID 30993792 DOI: 10.1002/Pro.3625  0.503
2019 Varney KM, Wilder PT, Godoy-Ruiz R, Mancia F, Weber DJ. HC, and N resonance assignments of human calmodulin bound to a peptide derived from the STRA6 vitamin A transporter (CaMBP2). Biomolecular Nmr Assignments. PMID 30875027 DOI: 10.1007/S12104-019-09890-1  0.745
2019 Wilder PT, Varney KM, Weber DJ. Targeting S100 Calcium-Binding Proteins with Small Molecule Inhibitors. Methods in Molecular Biology (Clifton, N.J.). 1929: 291-310. PMID 30710281 DOI: 10.1007/978-1-4939-9030-6_19  0.739
2018 Hernández-Ochoa EO, Melville Z, Vanegas C, Varney KM, Wilder PT, Melzer W, Weber DJ, Schneider MF. Loss of S100A1 expression leads to Ca release potentiation in mutant mice with disrupted CaM and S100A1 binding to CaMBD2 of RyR1. Physiological Reports. 6: e13822. PMID 30101473 DOI: 10.14814/Phy2.13822  0.825
2018 Conlon IL, Van Eker D, Abdelmalak S, Murphy WA, Bashir H, Sun M, Chauhan J, Varney KM, Godoy-Ruiz R, Wilder PT, Fletcher S. Kröhnke pyridines: Rapid and facile access to Mcl-1 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 29705141 DOI: 10.1016/J.Bmcl.2018.03.050  0.655
2017 Whiting E, Raje MR, Chauhan J, Wilder PT, Van Eker D, Hughes SJ, Bowen NG, Vickers GEA, Fenimore IC, Fletcher S. Discovery of Mcl-1 inhibitors based on a thiazolidine-2,4-dione scaffold. Bioorganic & Medicinal Chemistry Letters. PMID 29329659 DOI: 10.1016/J.Bmcl.2017.11.023  0.324
2017 Wilder PT, Weber DJ, Winstead A, Parnell S, Hinton TV, Stevenson M, Giri D, Azemati S, Olczak P, Powell BV, Odebode T, Tadesse S, Zhang Y, Pramanik SK, Wachira JM, et al. Unprecedented anticancer activities of organorhenium sulfonato and carboxylato complexes against hormone-dependent MCF-7 and hormone-independent triple-negative MDA-MB-231 breast cancer cells. Molecular and Cellular Biochemistry. PMID 28913709 DOI: 10.1007/S11010-017-3181-Z  0.524
2017 Melville Z, Hernandez-Ochoa EO, Pratt SJ, Liu Y, Pierce AD, Wilder PT, Adipietro KA, Breysse DH, Varney K, Schneider MF, Weber DJ. The activation of PKA by the calcium-binding protein S100A1 is independent of cyclic AMP. Biochemistry. PMID 28409622 DOI: 10.1021/Acs.Biochem.7B00117  0.824
2017 Alasady MJ, Adipietro KA, Pierce AD, Wilder PT, Hartman KG, Weber DJ, Hay N. Abstract 315: S100B regulates IL-6 signaling via the p90 ribosomal S6 kinase (RSK) in malignant melanoma Cancer Research. 77: 315-315. DOI: 10.1158/1538-7445.Am2017-315  0.76
2016 Cavalier MC, Melville Z, Aligholizadeh E, Raman EP, Yu W, Fang L, Alasady M, Pierce AD, Wilder PT, MacKerell AD, Weber DJ. Novel protein-inhibitor interactions in site 3 of Ca(2+)-bound S100B as discovered by X-ray crystallography. Acta Crystallographica. Section D, Structural Biology. 72: 753-760. PMID 27303795 DOI: 10.1107/S2059798316005532  0.811
2016 Lanning ME, Yu W, Yap JL, Chauhan J, Chen L, Whiting E, Pidugu LS, Atkinson T, Bailey H, Li W, Roth BM, Hynicka L, Chesko K, Toth EA, Shapiro P, ... ... Wilder PT, et al. Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2-naphthoates as selective inhibitors of the Mcl-1 oncoprotein. European Journal of Medicinal Chemistry. 113: 273-292. PMID 26985630 DOI: 10.1016/J.Ejmech.2016.02.006  0.8
2016 Drennen B, Scheenstra JA, Yap JL, Chen L, Lanning ME, Roth BM, Wilder PT, Fletcher S. Structural Re-engineering of the α-Helix Mimetic JY-1-106 into Small Molecules: Disruption of the Mcl-1-Bak-BH3 Protein-Protein Interaction with 2,6-Di-Substituted Nicotinates. Chemmedchem. PMID 26844930 DOI: 10.1002/Cmdc.201500461  0.774
2016 Chen L, Wilder PT, Drennen B, Tran J, Roth BM, Chesko K, Shapiro P, Fletcher S. Structure-based design of 3-carboxy-substituted 1,2,3,4-tetrahydroquinolines as inhibitors of myeloid cell leukemia-1 (Mcl-1). Organic & Biomolecular Chemistry. PMID 26751150 DOI: 10.1039/C5Ob02063H  0.792
2016 Cavalier MC, Ansari MI, Pierce AD, Wilder PT, McKnight LE, Raman EP, Neau DB, Bezawada P, Alasady MJ, Charpentier TH, Varney K, Toth EA, MacKerell AD, Coop A, Weber DJ. Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations. Journal of Medicinal Chemistry. PMID 26727270 DOI: 10.1021/Acs.Jmedchem.5B01369  0.79
2016 Cavalier MC, Wilder PT, Luci D, Maloney DJ, Fang L, Ansari MI, MacKerell AD, Coop A, Jadhav A, Weber DJ. Abstract 1358: Structure-based drug design of 3-site binding, high affinity inhibitors of S100B in malignant melanoma Cancer Research. 76: 1358-1358. DOI: 10.1158/1538-7445.Am2016-1358  0.812
2015 Lanning ME, Wilder PT, Bailey H, Drennen B, Cavalier M, Chen L, Yap JL, Raje M, Fletcher S. Towards more drug-like proteomimetics: two-faced, synthetic α-helix mimetics based on a purine scaffold. Organic & Biomolecular Chemistry. 13: 8642-6. PMID 26204921 DOI: 10.1039/C5Ob00478K  0.307
2015 Stowe SD, Cavalier MC, Godoy-Ruiz R, Varney KJ, Wilder PT, Gartenhaus RB, Weber DJ. Abstract 2454: Targeting the translational enhancer complex MCT-1:DenR to disrupt NHL survival Cancer Research. 75: 2454-2454. DOI: 10.1158/1538-7445.Am2015-2454  0.785
2015 Stowe SD, Cavalier MC, Godoy-Ruiz R, Varney KM, Wilder PT, Gartenhaus RB, Weber DJ. Characterizing the MCT-1:DenR Complex, a Translational Enhancer for Lymphoma Survival Biophysical Journal. 108: 219a. DOI: 10.1016/J.Bpj.2014.11.1212  0.781
2014 Cavalier MC, Pierce AD, Wilder PT, Alasady MJ, Hartman KG, Neau DB, Foley TL, Jadhav A, Maloney DJ, Simeonov A, Toth EA, Weber DJ. Covalent small molecule inhibitors of Ca(2+)-bound S100B. Biochemistry. 53: 6628-40. PMID 25268459 DOI: 10.1021/Bi5005552  0.819
2014 Dhar A, Mallick S, Ghosh P, Maiti A, Ahmed I, Bhattacharya S, Mandal T, Manna A, Roy K, Singh S, Nayak DK, Wilder PT, Markowitz J, Weber D, Ghosh MK, et al. Simultaneous inhibition of key growth pathways in melanoma cells and tumor regression by a designed bidentate constrained helical peptide. Biopolymers. 101: 344-58. PMID 24839139 DOI: 10.1002/Bip.22505  0.553
2014 Hartman KG, Vitolo MI, Pierce AD, Fox JM, Shapiro P, Martin SS, Wilder PT, Weber DJ. Complex formation between S100B protein and the p90 ribosomal S6 kinase (RSK) in malignant melanoma is calcium-dependent and inhibits extracellular signal-regulated kinase (ERK)-mediated phosphorylation of RSK. The Journal of Biological Chemistry. 289: 12886-95. PMID 24627490 DOI: 10.1074/Jbc.M114.561613  0.806
2013 Ramagopal UA, Dulyaninova NG, Varney KM, Wilder PT, Nallamsetty S, Brenowitz M, Weber DJ, Almo SC, Bresnick AR. Structure of the S100A4/myosin-IIA complex. Bmc Structural Biology. 13: 31. PMID 24252706 DOI: 10.1186/1472-6807-13-31  0.756
2013 Cao X, Yap JL, Newell-Rogers MK, Peddaboina C, Jiang W, Papaconstantinou HT, Jupitor D, Rai A, Jung KY, Tubin RP, Yu W, Vanommeslaeghe K, Wilder PT, MacKerell AD, Fletcher S, et al. The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak. Molecular Cancer. 12: 42. PMID 23680104 DOI: 10.1186/1476-4598-12-42  0.395
2013 Cavalier MC, McKnight L, Weber D, Wilder P. Abstract 2226: Structure/function characterization of SBi4225, a novel inhibitor of the calcium-binding protein S100B. Cancer Research. 73: 2226-2226. DOI: 10.1158/1538-7445.Am2013-2226  0.825
2013 Cavalier M, Wilder PT, Coop A, MacKerell A, Weber DJ. Abstract B103: Inhibitors of S100B (SBiXs) in malignant melanoma. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B103  0.821
2012 McKnight LE, Raman EP, Bezawada P, Kudrimoti S, Wilder PT, Hartman KG, Godoy-Ruiz R, Toth EA, Coop A, Mackerell AD, Weber DJ. Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B. Acs Medicinal Chemistry Letters. 3: 975-979. PMID 23264854 DOI: 10.1021/Ml300166S  0.82
2012 Yap JL, Cao X, Vanommeslaeghe K, Jung KY, Peddaboina C, Wilder PT, Nan A, MacKerell AD, Smythe WR, Fletcher S. Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors. Organic & Biomolecular Chemistry. 10: 2928-33. PMID 22395339 DOI: 10.1039/C2Ob07125H  0.335
2012 Hartman KG, Vitolo MI, Wilder PT, Fox J, Shapiro P, Martin SS, Weber DJ. Abstract 2164: S100B affects MAPK signaling in malignant melanoma via a direct interaction with RSK Cancer Research. 72: 2164-2164. DOI: 10.1158/1538-7445.Am2012-2164  0.8
2011 Xu Z, Chen YW, Battu A, Wilder P, Weber D, Yu W, Mackerell AD, Chen LM, Chai KX, Johnson MD, Lin CY. Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade. Journal of Medicinal Chemistry. 54: 7567-78. PMID 21966950 DOI: 10.1021/Jm200920S  0.507
2011 Yamaguchi N, Prosser BL, Ghassemi F, Xu L, Pasek DA, Eu JP, Hernández-Ochoa EO, Cannon BR, Wilder PT, Lovering RM, Weber D, Melzer W, Schneider MF, Meissner G. Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1. American Journal of Physiology. Cell Physiology. 300: C998-C1012. PMID 21289290 DOI: 10.1152/Ajpcell.00370.2010  0.761
2011 Wilder PT, Gianni K, Green DL, Weber DJ. Abstract 1372: A cell based high throughput screening assay for inhibitors of melanoma with high S100B Cancer Research. 71: 1372-1372. DOI: 10.1158/1538-7445.Am2011-1372  0.539
2011 Gianni K, Vitolo MI, Wilder PT, Martin SS, Weber DJ. Abstract 1054: S100B affects cell signaling in malignant melanoma Cancer Research. 71: 1054-1054. DOI: 10.1158/1538-7445.Am2011-1054  0.701
2010 Wilder PT, Charpentier TH, Liriano MA, Gianni K, Varney KM, Pozharski E, Coop A, Toth EA, Mackerell AD, Weber DJ. In vitro screening and structural characterization of inhibitors of the S100B-p53 interaction. International Journal of High Throughput Screening. 2010: 109-126. PMID 21132089 DOI: 10.2147/IJHTS.S8210  0.815
2010 Lin J, Yang Q, Wilder PT, Carrier F, Weber DJ. The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant melanoma. The Journal of Biological Chemistry. 285: 27487-98. PMID 20587415 DOI: 10.1074/Jbc.M110.155382  0.637
2010 Gilquin B, Cannon BR, Hubstenberger A, Moulouel B, Falk E, Merle N, Assard N, Kieffer S, Rousseau D, Wilder PT, Weber DJ, Baudier J. The calcium-dependent interaction between S100B and the mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A. Molecular and Cellular Biology. 30: 2724-36. PMID 20351179 DOI: 10.1128/Mcb.01468-09  0.784
2010 Charpentier TH, Thompson LE, Liriano MA, Varney KM, Wilder PT, Pozharski E, Toth EA, Weber DJ. The effects of CapZ peptide (TRTK-12) binding to S100B-Ca2+ as examined by NMR and X-ray crystallography. Journal of Molecular Biology. 396: 1227-43. PMID 20053360 DOI: 10.1016/J.Jmb.2009.12.057  0.83
2010 Gianni K, Wilder PT, Vitolo MI, Shapiro P, Weber DJ. Abstract 4125: The effects of S100B on cell signaling in malignant melanoma Cancer Research. 70: 4125-4125. DOI: 10.1158/1538-7445.Am10-4125  0.715
2009 Charpentier TH, Wilder PT, Liriano MA, Varney KM, Zhong S, Coop A, Pozharski E, MacKerell AD, Toth EA, Weber DJ. Small molecules bound to unique sites in the target protein binding cleft of calcium-bound S100B as characterized by nuclear magnetic resonance and X-ray crystallography. Biochemistry. 48: 6202-12. PMID 19469484 DOI: 10.1021/Bi9005754  0.835
2009 Wright NT, Cannon BR, Wilder PT, Morgan MT, Varney KM, Zimmer DB, Weber DJ. Solution structure of S100A1 bound to the CapZ peptide (TRTK12). Journal of Molecular Biology. 386: 1265-77. PMID 19452629 DOI: 10.1016/J.Jmb.2009.01.022  0.833
2008 Charpentier TH, Wilder PT, Liriano MA, Varney KM, Pozharski E, MacKerell AD, Coop A, Toth EA, Weber DJ. Divalent metal ion complexes of S100B in the absence and presence of pentamidine. Journal of Molecular Biology. 382: 56-73. PMID 18602402 DOI: 10.1016/J.Jmb.2008.06.047  0.813
2008 Malashkevich VN, Varney KM, Garrett SC, Wilder PT, Knight D, Charpentier TH, Ramagopal UA, Almo SC, Weber DJ, Bresnick AR. Structure of Ca2+-bound S100A4 and its interaction with peptides derived from nonmuscle myosin-IIA. Biochemistry. 47: 5111-26. PMID 18410126 DOI: 10.1021/Bi702537S  0.839
2007 Wilder PT, Charpentier TH, Weber DJ. Hydrocarbon-stapled helices: a novel approach for blocking protein-protein interactions. Chemmedchem. 2: 1149-51. PMID 17554748 DOI: 10.1002/Cmdc.200700102  0.767
2007 Charpentier TH, Wilder PT, Varney KM, Toth EA, Weber DJ. The 3D structures of Ca 2+ ‐S100B in Zn 2+ ‐ and pentamidine‐bound complexes as determined by X‐ray crystallography The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A630-A  0.798
2006 Wilder PT, Lin J, Bair CL, Charpentier TH, Yang D, Liriano M, Varney KM, Lee A, Oppenheim AB, Adhya S, Carrier F, Weber DJ. Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B. Biochimica Et Biophysica Acta. 1763: 1284-97. PMID 17010455 DOI: 10.1016/J.Bbamcr.2006.08.024  0.804
2005 Markowitz J, Rustandi RR, Varney KM, Wilder PT, Udan R, Wu SL, Horrocks WD, Weber DJ. Calcium-binding properties of wild-type and EF-hand mutants of S100B in the presence and absence of a peptide derived from the C-terminal negative regulatory domain of p53. Biochemistry. 44: 7305-14. PMID 15882069 DOI: 10.1021/Bi050321T  0.832
2005 Wilder PT, Varney KM, Weiss MB, Gitti RK, Weber DJ. Solution structure of zinc- and calcium-bound rat S100B as determined by nuclear magnetic resonance spectroscopy. Biochemistry. 44: 5690-702. PMID 15823027 DOI: 10.1021/Bi0475830  0.827
2004 Lin J, Yang Q, Yan Z, Markowitz J, Wilder PT, Carrier F, Weber DJ. Inhibiting S100B restores p53 levels in primary malignant melanoma cancer cells. The Journal of Biological Chemistry. 279: 34071-7. PMID 15178678 DOI: 10.1074/Jbc.M405419200  0.621
2003 Wilder PT, Baldisseri DM, Udan R, Vallely KM, Weber DJ. Location of the Zn(2+)-binding site on S100B as determined by NMR spectroscopy and site-directed mutagenesis. Biochemistry. 42: 13410-21. PMID 14621986 DOI: 10.1021/Bi035334Q  0.635
2003 Wilder P, Baldisseri D, Udan R, Vallely K, Weber D. 1H, 13C, and 15N resonance assignments for Zn2+ and Ca2+ bound S100B Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr5895  0.498
1998 Wilder PT, Rustandi RR, Drohat AC, Weber DJ. S100B(betabeta) inhibits the protein kinase C-dependent phosphorylation of a peptide derived from p53 in a Ca2+-dependent manner. Protein Science : a Publication of the Protein Society. 7: 794-8. PMID 9541413 DOI: 10.1002/Pro.5560070330  0.823
1998 Rustandi RR, Drohat AC, Baldisseri DM, Wilder PT, Weber DJ. The Ca(2+)-dependent interaction of S100B(beta beta) with a peptide derived from p53. Biochemistry. 37: 1951-60. PMID 9485322 DOI: 10.1021/Bi972701N  0.786
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