Patrick Aebischer - Publications

Affiliations: 
1984-1992 Medical Sciences Brown University, Providence, RI 
 1999- École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland 

65/287 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Lathuilière A, Cosson S, Lutolf MP, Schneider BL, Aebischer P. A high-capacity cell macroencapsulation system supporting the long-term survival of genetically engineered allogeneic cells. Biomaterials. 35: 779-91. PMID 24103654 DOI: 10.1016/j.biomaterials.2013.09.071  0.318
2013 Kunze A, Lengacher S, Dirren E, Aebischer P, Magistretti PJ, Renaud P. Astrocyte-neuron co-culture on microchips based on the model of SOD mutation to mimic ALS. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 964-75. PMID 23695230 DOI: 10.1039/C3Ib40022K  0.672
2007 Consiglio A, Martino S, Dolcetta D, Cusella G, Conese M, Marchesini S, Benaglia G, Wrabetz L, Orlacchio A, Déglon N, Aebischer P, Severini GM, Bordignon C. Metabolic correction in oligodendrocytes derived from metachromatic leukodystrophy mouse model by using encapsulated recombinant myoblasts. Journal of the Neurological Sciences. 255: 7-16. PMID 17341424 DOI: 10.1016/J.Jns.2007.01.010  0.388
2006 Behrstock S, Ebert A, McHugh J, Vosberg S, Moore J, Schneider B, Capowski E, Hei D, Kordower J, Aebischer P, Svendsen CN. Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. Gene Therapy. 13: 379-88. PMID 16355116 DOI: 10.1038/Sj.Gt.3302679  0.393
2006 Aebischer P, Wahlberg L, Tresco PA, Winn SR. Macroencapsulation of dopamine-secreting cells by coextrusion with an organic polymer solution1 The Biomaterials: Silver Jubilee Compendium. 61-67. DOI: 10.1016/B978-008045154-1.50009-5  0.639
2005 Ahn YH, Bensadoun JC, Aebischer P, Zurn AD, Seiger A, Björklund A, Lindvall O, Wahlberg L, Brundin P, Kaminski Schierle GS. Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor. Brain Research Bulletin. 66: 135-42. PMID 15982530 DOI: 10.1016/J.Brainresbull.2005.04.009  0.36
2005 Sajadi A, Bauer M, Thöny B, Aebischer P. Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production. Journal of Neurochemistry. 93: 1482-6. PMID 15935064 DOI: 10.1111/j.1471-4159.2005.03139.x  0.309
2004 Bloch J, Bachoud-Lévi AC, Déglon N, Lefaucheur JP, Winkel L, Palfi S, Nguyen JP, Bourdet C, Gaura V, Remy P, Brugières P, Boisse MF, Baudic S, Cesaro P, Hantraye P, ... Aebischer P, et al. Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study. Human Gene Therapy. 15: 968-75. PMID 15585112 DOI: 10.1089/Hum.2004.15.968  0.309
2004 Schwenter F, Schneider BL, Pralong WF, Déglon N, Aebischer P. Survival of encapsulated human primary fibroblasts and erythropoietin expression under xenogeneic conditions. Human Gene Therapy. 15: 669-80. PMID 15242527 DOI: 10.1089/1043034041361172  0.324
2003 Bjerkvig R, Read TA, Vajkoczy P, Aebischer P, Pralong W, Platt S, Melvik JE, Hagen A, Dornish M. Cell therapy using encapsulated cells producing endostatin. Acta Neurochirurgica. Supplement. 88: 137-41. PMID 14531571 DOI: 10.1007/978-3-7091-6090-9_19  0.333
2003 Schneider BL, Schwenter F, Pralong WF, Aebischer P. Prevention of the initial host immuno-inflammatory response determines the long-term survival of encapsulated myoblasts genetically engineered for erythropoietin delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 506-14. PMID 12727114 DOI: 10.1016/S1525-0016(03)00055-8  0.316
2003 Bensadoun JC, Pereira de Almeida L, Fine EG, Tseng JL, Déglon N, Aebischer P. Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors. Journal of Controlled Release : Official Journal of the Controlled Release Society. 87: 107-15. PMID 12618027 DOI: 10.1016/S0168-3659(02)00353-X  0.404
2002 Ostenfeld T, Tai YT, Martin P, Déglon N, Aebischer P, Svendsen CN. Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons. Journal of Neuroscience Research. 69: 955-65. PMID 12205689 DOI: 10.1002/jnr.10396  0.352
2000 Peduto G, Rinsch C, Schneider BL, Rolland E, Aebischer P. Long-term host unresponsiveness to encapsulated xenogeneic myoblasts after transient immunosuppression. Transplantation. 70: 78-85. PMID 10919579  0.336
1999 Boison D, Scheurer L, Tseng JL, Aebischer P, Mohler H. Seizure suppression in kindled rats by intraventricular grafting of an adenosine releasing synthetic polymer Experimental Neurology. 160: 164-174. PMID 10630201 DOI: 10.1006/Exnr.1999.7209  0.308
1999 Lysaght MJ, Aebischer P. Encapsulated cells as therapy. Scientific American. 280: 76-82. PMID 10201119 DOI: 10.1038/Scientificamerican0499-76  0.305
1998 Décosterd I, Buchser E, Gilliard N, Saydoff J, Zurn AD, Aebischer P. Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain Pain. 76: 159-166. PMID 9696469 DOI: 10.1016/S0304-3959(98)00044-X  0.303
1998 Tseng JL, Bruhn SL, Zurn AD, Aebischer P. Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy. Neuroreport. 9: 1817-22. PMID 9665607  0.385
1998 Sautter J, Tseng JL, Braguglia D, Aebischer P, Spenger C, Seiler RW, Widmer HR, Zurn AD. Implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor improve survival, growth, and function of fetal dopaminergic grafts Experimental Neurology. 149: 230-236. PMID 9454632 DOI: 10.1006/exnr.1997.6718  0.395
1997 Tseng JL, Baetge EE, Zurn AD, Aebischer P. GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine Journal of Neuroscience. 17: 325-333. PMID 8987758  0.354
1997 Déglon N, Heyd B, Tan SA, Joseph JM, Zurn AD, Aebischer P. Central nervous system delivery of recombinant ciliary neurotrophic factor by polymer encapsulated differentiated C2C12 myoblasts. Human Gene Therapy. 7: 2135-46. PMID 8934227 DOI: 10.1089/hum.1996.7.17-2135  0.391
1997 Aebischer P, Pochon NA, Heyd B, Deglon N, Joseph JM, Zurn AD, Baetge EE, Hammang JP, Goddard M, Lysaght M, Kaplan F, Kato AC, Schluep M, Hirt L, Regli F, et al. Gene therapy for amyotrophic lateral sclerosis (ALS) using a polymer encapsulated xenogenic cell line engineered to secrete hCNTF. Human Gene Therapy. 7: 851-60. PMID 8860837 DOI: 10.1089/hum.1996.7.7-851  0.354
1996 Aebischer P, Schluep M, Déglon N, Joseph JM, Hirt L, Heyd B, Goddard M, Hammang JP, Zurn AD, Kato AC, Regli F, Baetge EE. Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients. Nature Medicine. 2: 696-9. PMID 8640564 DOI: 10.1038/nm0696-696  0.313
1996 Tan S, Déglon N, Zurn A, Baetge E, Bamber B, Kato A, Aebischer P. Rescue of Motoneurons from Axotomy-Induced Cell Death by Polymer Encapsulated Cells Genetically Engineered to Release CNTF Cell Transplantation. 5: 577-587. DOI: 10.1177/096368979600500507  0.34
1996 Joseph JM, Degion N, Schluep M, Hirt L, Martinet O, Baetge E, Goddard M, Zurn A, Regli F, Aebischer P. Transplantation of an encapsulated genetically engineered cell line releasing ciliary neurotrophic factor in LOU gehrig disease Cell Transplantation. 5: 80. DOI: 10.1016/0963-6897(96)82323-2  0.376
1995 Aebischer P, Kato AC. Treatment of amyotrophic lateral sclerosis using a gene therapy approach. European Neurology. 35: 65-8. PMID 7796839 DOI: 10.1159/000117095  0.337
1995 Zurn AD, Baetge EE, Hammang JP, Tan SA, Aebischer P. Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones. Neuroreport. 6: 113-8. PMID 7703397 DOI: 10.1097/00001756-199412300-00030  0.353
1995 Vargo TG, Bekos EJ, Kim YS, Ranieri JP, Bellamkonda R, Aebischer P, Margevich DE, Thompson PM, Bright FV, Gardella JA. Synthesis and characterization of fluoropolymeric substrata with immobilized minimal peptide sequences for cell adhesion studies. I. Journal of Biomedical Materials Research. 29: 767-78. PMID 7593014 DOI: 10.1002/Jbm.820290613  0.556
1995 Sagot Y, Tan SA, Baetge E, Schmalbruch H, Kato AC, Aebischer P. Polymer encapsulated cell lines genetically engineered to release ciliary neurotrophic factor can slow down progressive motor neuronopathy in the mouse. The European Journal of Neuroscience. 7: 1313-22. PMID 7582105 DOI: 10.1111/j.1460-9568.1995.tb01122.x  0.395
1994 Guénard V, Aebischer P, Bunge RP. The astrocyte inhibition of peripheral nerve regeneration is reversed by Schwann cells. Experimental Neurology. 126: 44-60. PMID 8157126 DOI: 10.1006/exnr.1994.1041  0.323
1994 Aebischer P, Goddard M, Signore AP, Timpson RL. Functional Recovery in Hemiparkinsonian Primates Transplanted with Polymer-Encapsulated PC12 Cells Experimental Neurology. 126: 151-158. PMID 7925816 DOI: 10.1006/Exnr.1994.1053  0.543
1994 Zielinski BA, Aebischer P. Chitosan as a matrix for mammalian cell encapsulation. Biomaterials. 15: 1049-56. PMID 7888575 DOI: 10.1016/0142-9612(94)90090-6  0.499
1993 Hoffman D, Breakefield XO, Short MP, Aebischer P. Transplantation of a polymer-encapsulated cell line genetically engineered to release NGF. Experimental Neurology. 122: 100-6. PMID 8339781 DOI: 10.1006/exnr.1993.1111  0.427
1993 Sagen J, Wang H, Tresco PA, Aebischer P. Transplants of immunologically isolated xenogeneic chromaffin cells provide a long-term source of pain-reducing neuroactive substances. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 2415-23. PMID 7684773 DOI: 10.1523/Jneurosci.13-06-02415.1993  0.651
1993 Sanberg PR, Emerich DF, Aebischer P, Amisetti SM, Ouellette W, Koutouzis TK, Cahill DW, Norman AB. Substance P containing polymer implants protect against striatal excitotoxicity. Brain Research. 628: 327-9. PMID 7508810 DOI: 10.1016/0006-8993(93)90974-R  0.374
1992 Tresco PA, Winn SR, Tan S, Jaeger CB, Greene LA, Aebischer P. POLYMER-ENCAPSULATED PC12 CELLS: LONG-TERM SURVIVAL AND ASSOCIATED REDUCTION IN LESION-INDUCED ROTATIONAL BEHAVIOR. Cell Transplantation. 1: 255-264. PMID 28153072  0.701
1992 Valentini RF, Vargo TG, Gardella JA, Aebischer P. Electrically charged polymeric substrates enhance nerve fibre outgrowth In vitro Biomaterials. 13: 183-190. PMID 1567943 DOI: 10.1016/0142-9612(92)90069-Z  0.362
1992 Winn SR, Tresco PA, Zielinski B, Sagen J, Aebischer P. Microencapsulated bovine chromaffin cells in vitro: effect of density and coseeding with a NGF-releasing cell line. Journal of Neural Transplantation & Plasticity. 3: 115-24. PMID 1515479 DOI: 10.1155/Np.1992.115  0.712
1992 Jaeger CB, Aebischer P, Tresco PA, Winn SR, Greene LA. Growth of tumour cell lines in polymer capsules: ultrastructure of encapsulated PC12 cells. Journal of Neurocytology. 21: 469-80. PMID 1500946 DOI: 10.1007/Bf01186951  0.73
1992 Tresco PA, Winn SR, Aebischer P. Polymer encapsulated neurotransmitter secreting cells. Potential treatment for Parkinson's disease. Asaio Journal (American Society For Artificial Internal Organs : 1992). 38: 17-23. PMID 1348191 DOI: 10.1097/00002480-199201000-00006  0.716
1992 Tresco PA, Winn SR, Tan S, Jaeger CB, Greene LA, Aebischer P. Polymer-encapsulated PC12 cells: long-term survival and associated reduction in lesion-induced rotational behavior. Cell Transplantation. 1: 255-64. PMID 1344297 DOI: 10.1177/0963689792001002-307  0.723
1992 Guenard V, Kleitman N, Morrissey T, Bunge R, Aebischer P. Syngeneic Schwann cells derived from adult nerves seeded in semipermeable guidance channels enhance peripheral nerve regeneration The Journal of Neuroscience. 12: 3310-3320. DOI: 10.1523/Jneurosci.12-09-03310.1992  0.356
1991 Aebischer P, Lacy PE, Gerasimidi-Vazeou A, Hauptfeld V. Production of Marked Prolongation of Islet Xenograft Survival (Rat to Mouse) by Local Release of Mouse and Rat Antilymphocyte Sera at Transplant Site Diabetes. 40: 482-485. PMID 2010049 DOI: 10.2337/Diab.40.4.482  0.367
1991 Aebischer P, Wahlberg L, Tresco PA, Winn SR. Macroencapsulation of dopamine-secreting cells by coextrusion with an organic polymer solution. Biomaterials. 12: 50-6. PMID 2009346 DOI: 10.1016/0142-9612(91)90132-T  0.7
1991 Aebischer P, Tresco PA, Winn SR, Greene LA, Jaeger CB. Long-term cross-species brain transplantation of a polymer-encapsulated dopamine-secreting cell line. Experimental Neurology. 111: 269-75. PMID 1999230 DOI: 10.1016/0014-4886(91)90093-R  0.73
1991 Winn SR, Tresco PA, Zielinski B, Greene LA, Jaeger CB, Aebischer P. Behavioral recovery following intrastriatal implantation of microencapsulated PC12 cells. Experimental Neurology. 113: 322-9. PMID 1915723 DOI: 10.1016/0014-4886(91)90022-5  0.727
1991 Jaeger CB, Winn SR, Tresco PA, Aebischer P. Repair of the blood-brain barrier following implantation of polymer capsules. Brain Research. 551: 163-70. PMID 1913150 DOI: 10.1016/0006-8993(91)90929-P  0.634
1991 Guénard V, Valentini RF, Aebischer P. Influence of surface texture of polymeric sheets on peripheral nerve regeneration in a two-compartment guidance system Biomaterials. 12: 259-263. PMID 1878462 DOI: 10.1016/0142-9612(91)90210-2  0.345
1991 Aebischer P, Winn SR, Tresco PA, Jaeger CB, Greene LA. Transplantation of polymer encapsulated neurotransmitter secreting cells: effect of the encapsulation technique. Journal of Biomechanical Engineering. 113: 178-83. PMID 1875690 DOI: 10.1115/1.2891231  0.718
1991 Guénard V, Dinarello CA, Weston PJ, Aebischer P. Peripheral nerve regeneration is impeded by interleukin-1 receptor antagonist released from a polymeric guidance channel. Journal of Neuroscience Research. 29: 396-400. PMID 1833560 DOI: 10.1002/Jnr.490290315  0.308
1991 Fine EG, Valentini RF, Bellamkonda R, Aebischer P. Improved nerve regeneration through piezoelectric vinylidenefluoride-trifluoroethylene copolymer guidance channels Biomaterials. 12: 775-780. PMID 1799653 DOI: 10.1016/0142-9612(91)90029-A  0.551
1991 Christenson L, Wahlberg L, Aebischer P. Mast cells and tissue reaction to intraperitoneally implanted polymer capsules Journal of Biomedical Materials Research. 25: 1119-1131. PMID 1778997 DOI: 10.1002/Jbm.820250906  0.424
1991 Aebischer P, Tresco PA, Sagen J, Winn SR. Transplantation of microencapsulated bovine chromaffin cells reduces lesion-induced rotational asymmetry in rats. Brain Research. 560: 43-9. PMID 1760745 DOI: 10.1016/0006-8993(91)91212-J  0.735
1990 Ip TK, Galletti PM, Aebischer P. Effects of attachment substrates on the growth and differentiation of LLC-PK1 cells. In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association. 26: 162-8. PMID 2312499 DOI: 10.1007/Bf02624108  0.35
1990 Jaeger CB, Greene LA, Tresco PA, Winn SR, Aebischer P. Polymer encapsulated dopaminergic cell lines as "alternative neural grafts". Progress in Brain Research. 82: 41-6. PMID 2290954  0.676
1990 Hoffman D, Wahlberg L, Aebischer P. NGF released from a polymer matrix prevents loss of ChAT expression in basal forebrain neurons following a fimbria-fornix lesion. Experimental Neurology. 110: 39-44. PMID 2209780 DOI: 10.1016/0014-4886(90)90049-X  0.441
1990 Jaeger CB, Greene LA, Tresco PA, Winn SR, Aebischer P. Polymer encapsulated dopaminergic cell lines as 'alternative neural grafts' Progress in Brain Research. 82: 41-46. DOI: 10.1016/S0079-6123(08)62588-1  0.715
1989 Aebischer P, Salessiotis AN, Winn SR. Basic fibroblast growth factor released from synthetic guidance channels facilitates peripheral nerve regeneration across long nerve gaps. Journal of Neuroscience Research. 23: 282-289. PMID 2769793 DOI: 10.1002/Jnr.490230306  0.366
1989 Christenson L, Aebischer P, McMillan P, Galletti PM. Tissue reaction to intraperitoneal polymer implants: species difference and effects of corticoid and doxorubicin. Journal of Biomedical Materials Research. 23: 705-18. PMID 2661559 DOI: 10.1002/Jbm.820230704  0.366
1989 Winn SR, Wahlberg L, Tresco PA, Aebischer P. An encapsulated dopamine-releasing polymer alleviates experimental parkinsonism in rats. Experimental Neurology. 105: 244-50. PMID 2504616 DOI: 10.1016/0014-4886(89)90126-X  0.668
1989 Winn SR, Aebischer P, Galletti PM. Brain tissue reaction to permselective polymer capsules. Journal of Biomedical Materials Research. 23: 31-44. PMID 2468675 DOI: 10.1002/Jbm.820230104  0.427
1989 Aebischer P, Guenard V, Brace S. Peripheral nerve regeneration through blind-ended semipermeable guidance channels: effect of the molecular weight cutoff The Journal of Neuroscience. 9: 3590-3595. DOI: 10.1523/Jneurosci.09-10-03590.1989  0.318
1988 Aebischer P, Winn SR, Galletti PM. Transplantation of neural tissue in polymer capsules. Brain Research. 448: 364-8. PMID 3378159 DOI: 10.1016/0006-8993(88)91278-4  0.384
1988 Aebischer P, Goddard MB, Sasken HF, Hunter TJ, Galletti PM. Tissue reaction to fabrics coated with turbostratic carbon: subcutaneous versus vascular implants. Biomaterials. 9: 80-85. PMID 2964876 DOI: 10.1016/0142-9612(88)90075-0  0.334
1988 Galletti PM, Aebischer P, Sasken HF, Goddard MB, Chiu T. Experience with fully bioresorbable aortic grafts in the dog. Surgery. 103: 231-241. DOI: 10.5555/Uri:Pii:0039606088902279  0.386
Low-probability matches (unlikely to be authored by this person)
1998 Régulier E, Schneider BL, Déglon N, Beuzard Y, Aebischer P. Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts Gene Therapy. 5: 1014-1022. PMID 10326023  0.298
1988 Aebischer P, Valentini RF, Winn SR, Galletti PM. The use of a semi-permeable tube as a guidance channel for a transected rabbit optic nerve Progress in Brain Research. 78: 599-603. PMID 3247455 DOI: 10.1016/S0079-6123(08)60336-2  0.297
1989 Valentini RF, Sabatini AM, Dario P, Aebischer P. Polymer electret guidance channels enhance peripheral nerve regeneration in mice. Brain Research. 480: 300-4. PMID 2713656 DOI: 10.1016/0006-8993(89)90196-0  0.296
2006 Sajadi A, Bensadoun JC, Schneider BL, Lo Bianco C, Aebischer P. Transient striatal delivery of GDNF via encapsulated cells leads to sustained behavioral improvement in a bilateral model of Parkinson disease. Neurobiology of Disease. 22: 119-29. PMID 16300956 DOI: 10.1016/j.nbd.2005.10.006  0.295
1988 Aebischer P, Guénard V, Winn SR, Valentini RF, Galletti PM. Blind-ended semipermeable guidance channels support peripheral nerve regeneration in the absence of a distal nerve stump Brain Research. 454: 179-187. PMID 3409002 DOI: 10.1016/0006-8993(88)90817-7  0.294
1987 Valentini RF, Aebischer P, Winn SR, Galletti PM. Collagen- and laminin-containing gels impede peripheral nerve regeneration through semipermeable nerve guidance channels Experimental Neurology. 98: 350-356. PMID 3666083 DOI: 10.1016/0014-4886(87)90247-0  0.293
1996 Buchser E, Goddard M, Heyd B, Joseph JM, Favre J, de Tribolet N, Lysaght M, Aebischer P. Immunoisolated xenogenic chromaffin cell therapy for chronic pain. Initial clinical experience. Anesthesiology. 85: 1005-12; discussion . PMID 8916816 DOI: 10.1097/00000542-199611000-00007  0.291
2000 Zurn AD, Henry H, Schluep M, Aubert V, Winkel L, Eilers B, Bachmann C, Aebischer P. Evaluation of an intrathecal immune response in amyotrophic lateral sclerosis patients implanted with encapsulated genetically engineered xenogeneic cells Cell Transplantation. 9: 471-484. PMID 11038064  0.29
1999 Dalle B, Payen E, Regulier E, Deglon N, Rouyer-Fessard P, Beuzard Y, Aebischer P. Improvement of mouse β-thalassemia upon erythropoietin delivery by encapsulated myoblasts Gene Therapy. 6: 157-161. PMID 10435099 DOI: 10.1038/sj.gt.3300812  0.287
1998 Borkenhagen M, Stoll RC, Neuenschwander P, Suter UW, Aebischer P. In vivo performance of a new biodegradable polyester urethane system used as a nerve guidance channel. Biomaterials. 19: 2155-65. PMID 9884056 DOI: 10.1016/S0142-9612(98)00122-7  0.285
2000 Hottinger AF, Azzouz M, Deglon N, Aebischer P, Zurn AD. Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus Journal of Neuroscience. 20: 5587-5593. PMID 10908595  0.285
1987 Aebischer P, Valentini RF, Dario P, Domenici C, Galletti PM. Piezoelectric guidance channels enhance regeneration in the mouse sciatic nerve after axotomy. Brain Research. 436: 165-8. PMID 3690349 DOI: 10.1016/0006-8993(87)91570-8  0.284
2000 Bachoud-Lévi AC, Déglon N, Nguyen JP, Bloch J, Bourdet C, Winkel L, Rémy P, Goddard M, Lefaucheur JP, Brugières P, Baudic S, Cesaro P, Peschanski M, Aebischer P. Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF. Human Gene Therapy. 11: 1723-9. PMID 10954906 DOI: 10.1089/10430340050111377  0.283
1993 Makohliso SA, Valentini RF, Aebischer P. Magnitude and polarity of a fluoroethylene propylene electret substrate charge influences neurite outgrowth in vitro Journal of Biomedical Materials Research. 27: 1075-1085. PMID 8408120 DOI: 10.1002/Jbm.820270813  0.282
1998 Vejsada R, Tseng JL, Lindsay RM, Acheson A, Aebischer P, Kato AC. Synergistic but transient rescue effects of BDNF and GDNF on axotomized neonatal motoneurons. Neuroscience. 84: 129-39. PMID 9522368 DOI: 10.1016/S0306-4522(97)00497-1  0.278
2005 Klein SM, Behrstock S, McHugh J, Hoffmann K, Wallace K, Suzuki M, Aebischer P, Svendsen CN. GDNF delivery using human neural progenitor cells in a rat model of ALS. Human Gene Therapy. 16: 509-21. PMID 15871682 DOI: 10.1089/Hum.2005.16.509  0.276
2001 Zurn AD, Widmer HR, Aebischer P. Sustained delivery of GDNF: Towards a treatment for Parkinson's disease Brain Research Reviews. 36: 222-229. PMID 11690619 DOI: 10.1016/S0165-0173(01)00098-4  0.275
2002 Palfi S, Leventhal L, Chu Y, Ma SY, Emborg M, Bakay R, Déglon N, Hantraye P, Aebischer P, Kordower JH. Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4942-54. PMID 12077191 DOI: 10.1523/Jneurosci.22-12-04942.2002  0.275
1989 Ip TK, Aebischer P. Renal epithelial-cell-controlled solute transport across permeable membranes as the foundation for a bioartificial kidney. Artificial Organs. 13: 58-65. PMID 2653286 DOI: 10.1111/J.1525-1594.1989.Tb02833.X  0.273
1996 Zum AD, Tseng J, Aebischer P. Symptomatic cell therapies cells as biological minipumps European Neurology. 36: 405-408.  0.272
1994 Kokaia M, Aebischer P, Elmér E, Bengzon J, Kalén P, Kokaia Z, Lindvall O. Seizure suppression in kindling epilepsy by intracerebral implants of GABA- but not by noradrenaline-releasing polymer matrices. Experimental Brain Research. 100: 385-94. PMID 7813677 DOI: 10.1007/Bf02738399  0.266
2001 Schneider BL, Peduto G, Aebischer P. A self-immunomodulating myoblast cell line for erythropoietin delivery. Gene Therapy. 8: 58-66. PMID 11402302 DOI: 10.1038/sj.gt.3301356  0.264
1990 Aebischer P, Guénard V, Valentini RF. The morphology of regenerating peripheral nerves is modulated by the surface microgeometry of polymeric guidance channels Brain Research. 531: 211-218. PMID 2289122 DOI: 10.1016/0006-8993(90)90776-8  0.264
2012 Aebischer P, Tan SA, Déglon N, Heyd B, Zurn A, Baetge E, Sagot Y, Kato A. Encapsulation of neurotrophic factor-releasing cells for the treatment of neurodegenerative diseases. Restorative Neurology and Neuroscience. 8: 65-6. PMID 21551809 DOI: 10.3233/RNN-1995-81215  0.264
2009 Redmond DE, Elsworth JD, Roth RH, Leranth C, Collier TJ, Blanchard B, Bjugstad KB, Samulski RJ, Aebischer P, Sladek JR. Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF. The Journal of Comparative Neurology. 515: 31-40. PMID 19399891 DOI: 10.1002/Cne.22028  0.263
1987 VALENTINI RF, AEBISCHER P, WINN SR, PANOL G, GALLETTI PM. Bridging a Transected Rat Optic Nerve with a Semipermeable Guidance Channel Annals of the New York Academy of Sciences. 495: 800-803. DOI: 10.1111/J.1749-6632.1987.Tb23743.X  0.26
2008 Emborg ME, Ebert AD, Moirano J, Peng S, Suzuki M, Capowski E, Joers V, Roitberg BZ, Aebischer P, Svendsen CN. GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeys. Cell Transplantation. 17: 383-95. PMID 18522241 DOI: 10.3727/096368908784423300  0.26
2004 Kishima H, Poyot T, Bloch J, Dauguet J, Condé F, Dollé F, Hinnen F, Pralong W, Palfi S, Déglon N, Aebischer P, Hantraye P. Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons. Neurobiology of Disease. 16: 428-39. PMID 15193299 DOI: 10.1016/J.Nbd.2004.03.012  0.259
2000 Ridet JL, Déglon N, Aebischer P. Gene transfer techniques for the delivery of GDNF in Parkinson's disease Novartis Foundation Symposium. 231: 202-215. PMID 11131539  0.257
2012 Gaugler MN, Genc O, Bobela W, Mohanna S, Ardah MT, El-Agnaf OM, Cantoni M, Bensadoun JC, Schneggenburger R, Knott GW, Aebischer P, Schneider BL. Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity. Acta Neuropathologica. 123: 653-69. PMID 22361813 DOI: 10.1007/s00401-012-0963-y  0.254
1996 Makohliso SA, Aebischer P, Giovangrandi L, Buhlmann HJ, Dutoit M. Biomimetic materials approach towards the development of a neural cell-based biosensor Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 81-82.  0.249
2007 Capowski EE, Schneider BL, Ebert AD, Seehus CR, Szulc J, Zufferey R, Aebischer P, Svendsen CN. Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy. Journal of Neuroscience Methods. 163: 338-49. PMID 17397931 DOI: 10.1016/J.Jneumeth.2007.02.022  0.248
2001 Rinsch C, Peduto G, Schneider BL, Aebischer P. Inducing host acceptance to encapsulated xenogeneic myoblasts. Transplantation. 71: 345-51. PMID 11233892  0.248
1996 Zurn AD, Tseng J, Aebischer P. Treatment of Parkinson's disease. Symptomatic cell therapies: cells as biological minipumps European Neurology. 36: 405-408. PMID 8954314  0.246
2004 Schwenter F, Bouche N, Pralong WF, Aebischer P. In vivo calcium deposition on polyvinyl alcohol matrix used in hollow fiber cell macroencapsulation devices. Biomaterials. 25: 3861-8. PMID 15020162 DOI: 10.1016/j.biomaterials.2003.10.030  0.243
2002 Aszmann OC, Korak KJ, Kropf N, Fine E, Aebischer P, Frey M. Simultaneous GDNF and BDNF application leads to increased motoneuron survival and improved functional outcome in an experimental model for obstetric brachial plexus lesions. Plastic and Reconstructive Surgery. 110: 1066-72. PMID 12198419 DOI: 10.1097/01.PRS.0000020990.82332.43  0.24
2003 Déglon N, Aubert V, Spertini F, Winkel L, Aebischer P. Presence of Gal-alpha1,3Gal epitope on xenogeneic lines: implications for cellular gene therapy based on the encapsulation technology. Xenotransplantation. 10: 204-13. PMID 12694540 DOI: 10.1034/j.1399-3089.2003.00110.x  0.24
1996 Tan SA, Aebischer P. The problems of delivering neuroactive molecules to the CNS Ciba Foundation Symposia. 211-239. PMID 8866136  0.239
2012 Tseng JL, Aebischer P. Encapsulated cell implants as a novel treatment for Parkinson's disease. Methods in Molecular Medicine. 62: 279-88. PMID 21318783 DOI: 10.1385/1-59259-142-6:279  0.236
1995 Rensing-Ehl A, Frei K, Flury R, Matiba B, Mariani SM, Weller M, Aebischer P, Krammer PH, Fontana A. Local Fas/APO-1 (CD95) ligand-mediated tumor cell killing in vivo. European Journal of Immunology. 25: 2253-8. PMID 7545115 DOI: 10.1002/eji.1830250821  0.233
2002 Sommer B, Rinsch C, Payen E, Dalle B, Schneider B, Déglon N, Henri A, Beuzard Y, Aebischer P. Long-term doxycycline-regulated secretion of erythropoietin by encapsulated myoblasts Molecular Therapy. 6: 155-161. PMID 12161181 DOI: 10.1006/mthe.2002.0646  0.231
1999 Rinsch C, Schneider BL, Aebischer P. Highlights of the cell transplantation meeting at Montreux, March 1999. Cell Transplantation. 8: 571-6. PMID 10701484 DOI: 10.1177/096368979900800601  0.23
1984 Aebischer P, Schultz W. The activity of pars compacta neurons of the monkey substantia nigra is depressed by apomorphine. Neuroscience Letters. 50: 25-9. PMID 6493628 DOI: 10.1016/0304-3940(84)90456-7  0.229
2014 Lathuilière A, Bohrmann B, Kopetzki E, Schweitzer C, Jacobsen H, Moniatte M, Aebischer P, Schneider BL. Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation. Biomaterials. 35: 792-802. PMID 24344356 DOI: 10.1016/j.biomaterials.2013.10.026  0.229
2011 Marroquin Belaunzaran O, Cordero MI, Setola V, Bianchi S, Galli C, Bouche N, Mlynarik V, Gruetter R, Sandi C, Bensadoun JC, Molinari M, Aebischer P. Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool. Plos One. 6: e18268. PMID 21533130 DOI: 10.1371/Journal.Pone.0018268  0.228
2015 Sotelo-Hitschfeld T, Niemeyer MI, Mächler P, Ruminot I, Lerchundi R, Wyss MT, Stobart J, Fernández-Moncada I, Valdebenito R, Garrido-Gerter P, Contreras-Baeza Y, Schneider BL, Aebischer P, Lengacher S, San Martín A, et al. Channel-mediated lactate release by K⁺-stimulated astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 4168-78. PMID 25762664 DOI: 10.1523/Jneurosci.5036-14.2015  0.228
1999 Hottinger AF, Aebischer P. Treatment of diseases of the central nervous system using encapsulated cells Advances and Technical Standards in Neurosurgery. 25: 3-20. PMID 10370715  0.226
2007 Suzuki M, McHugh J, Tork C, Shelley B, Klein SM, Aebischer P, Svendsen CN. GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS. Plos One. 2: e689. PMID 17668067 DOI: 10.1371/Journal.Pone.0000689  0.225
2000 Bensadoun JC, Déglon N, Tseng JL, Ridet JL, Zurn AD, Aebischer P. Lentiviral vectors as a gene delivery system in the mouse midbrain: Cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF Experimental Neurology. 164: 15-24. PMID 10877911 DOI: 10.1006/exnr.2000.7409  0.223
1997 Rinsch C, Régulier E, Déglon N, Dalle B, Beuzard Y, Aebischer P. A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension Human Gene Therapy. 8: 1881-1889. PMID 9382954  0.222
2004 Sajadi A, Schneider BL, Aebischer P. Wlds-mediated protection of dopaminergic fibers in an animal model of Parkinson disease. Current Biology : Cb. 14: 326-30. PMID 14972684 DOI: 10.1016/j.cub.2004.01.053  0.221
1998 Borkenhagen M, Clémence JF, Sigrist H, Aebischer P. Three-dimensional extracellular matrix engineering in the nervous system Journal of Biomedical Materials Research. 40: 392-400. PMID 9570070 DOI: 10.1002/(SICI)1097-4636(19980603)40:3<392::AID-JBM8>3.0.CO;2-C  0.221
2001 Huber A, Padrun V, Déglon N, Aebischer P, Möhler H, Boison D. Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy Proceedings of the National Academy of Sciences of the United States of America. 98: 7611-7616. PMID 11404469 DOI: 10.1073/Pnas.131102898  0.22
2002 Pericin M, Althage A, Freigang S, Hengartner H, Rolland E, Dupraz P, Thorens B, Aebischer P, Zinkernagel RM. Allogeneic beta-islet cells correct diabetes and resist immune rejection. Proceedings of the National Academy of Sciences of the United States of America. 99: 8203-6. PMID 12060765 DOI: 10.1073/pnas.122241299  0.219
2006 Ridet JL, Bensadoun JC, Déglon N, Aebischer P, Zurn AD. Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease. Neurobiology of Disease. 21: 29-34. PMID 16023352 DOI: 10.1016/j.nbd.2005.06.003  0.214
1994 Aebischer P, Buchser E, Joseph JM, Favre J, de Tribolet N, Lysaght M, Rudnick S, Goddard M. TRANSPLANTATION IN HUMANS OF ENCAPSULATED XENOGENEIC CELLS WITHOUT IMMUNOSUPPRESSION Transplantation. 58: 1275-1277. DOI: 10.1097/00007890-199412150-00025  0.213
1994 Levi A, Guenard V, Aebischer P, Bunge R. The functional characteristics of Schwann cells cultured from human peripheral nerve after transplantation into a gap within the rat sciatic nerve The Journal of Neuroscience. 14: 1309-1319. DOI: 10.1523/JNEUROSCI.14-03-01309.1994  0.213
1999 Aebischer P, Kato A. The Cell Transplant Society Fourth International Congress: Welcome Address Cell Transplantation. 8: 1-1. DOI: 10.1177/096368979900800201  0.213
2000 Aebischer P. The contribution of encapsulation to cell therapy European Cytokine Network. 11: 327-328.  0.212
2002 Barras FM, Pasche P, Bouche N, Aebischer P, Zurn AD. Glial cell line-derived neurotrophic factor released by synthetic guidance channels promotes facial nerve regeneration in the rat. Journal of Neuroscience Research. 70: 746-55. PMID 12444596 DOI: 10.1002/jnr.10434  0.21
2008 Suzuki M, McHugh J, Tork C, Shelley B, Hayes A, Bellantuono I, Aebischer P, Svendsen CN. Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 2002-10. PMID 18797452 DOI: 10.1038/Mt.2008.197  0.208
2002 de Almeida LP, Ross CA, Zala D, Aebischer P, Déglon N. Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3473-83. PMID 11978824 DOI: 10.1523/Jneurosci.22-09-03473.2002  0.205
2006 Emborg ME, Roitberg BZ, Moirano J, Zufferey R, Ebert AD, Joers V, Holden J, Converse AK, Koprich JB, Kordower JH, Aebischer P. Lentiviral Delivery of Glial Cell Line-derived Neurotrophic Factor in Aged 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated Rhesus Monkeys 883. Neurosurgery. 59: 481-482. PMID 28180727 DOI: 10.1227/00006123-200608000-00121  0.204
2006 Aebischer P, Goddard M, Galletti PM, Lysaght M. Biomaterials and Artificial Organs Materials Science and Technology. DOI: 10.1002/9783527603978.Mst0163  0.201
1997 Pochon NAM, Menoud A, Tseng JL, Zurn AD, Aebischer P. Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridization European Journal of Neuroscience. 9: 463-471. PMID 9104588 DOI: 10.1111/j.1460-9568.1997.tb01623.x  0.198
2000 Kordower JH, Emborg ME, Bloch J, Ma SY, Chu Y, Leventhal L, McBride J, Chen EY, Palfi S, Roitberg BZ, Brown WD, Holden JE, Pyzalski R, Taylor MD, Carvey P, ... ... Aebischer P, et al. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science (New York, N.Y.). 290: 767-73. PMID 11052933 DOI: 10.1126/Science.290.5492.767  0.197
2002 Fine EG, Decosterd I, Papaloïzos M, Zurn AD, Aebischer P. GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap. The European Journal of Neuroscience. 15: 589-601. PMID 11886440 DOI: 10.1046/j.1460-9568.2002.01892.x  0.197
2005 Zala D, Benchoua A, Brouillet E, Perrin V, Gaillard MC, Zurn AD, Aebischer P, Déglon N. Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment. Neurobiology of Disease. 20: 785-98. PMID 16006135 DOI: 10.1016/J.Nbd.2005.05.017  0.195
2001 De Almeida LP, Zala D, Aebischer P, Déglon N. Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease Neurobiology of Disease. 8: 433-446. PMID 11442352 DOI: 10.1006/nbdi.2001.0388  0.194
1994 Kokaia M, Aebischer P, Elm�r E, Bengzon J, Kal�n P, Kokaia Z, Lindvall O. Seizure suppression in kindling epilepsy by intracerebral implants of GABA- but not by noradrenaline-releasing polymer matrices Experimental Brain Research. 79. DOI: 10.1007/BF00229179  0.191
2009 Ulusoy A, Sahin G, Björklund T, Aebischer P, Kirik D. Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1574-84. PMID 19584816 DOI: 10.1038/Mt.2009.142  0.19
1999 Kordower JH, Bloch J, Ma SY, Chu Y, Palfi S, Roitberg BZ, Emborg M, Hantraye P, Déglon N, Aebischer P. Lentiviral gene transfer to the nonhuman primate brain. Experimental Neurology. 160: 1-16. PMID 10630186 DOI: 10.1006/Exnr.1999.7178  0.189
2000 Déglon N, Tseng JL, Bensadoun JC, Zurn AD, Arsenijevic Y, De Almeida LP, Zufferey R, Trono D, Aebischer P. Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease Human Gene Therapy. 11: 179-190. PMID 10646649 DOI: 10.1089/10430340050016256  0.188
2013 Krakora D, Mulcrone P, Meyer M, Lewis C, Bernau K, Gowing G, Zimprich C, Aebischer P, Svendsen CN, Suzuki M. Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1602-10. PMID 23712039 DOI: 10.1038/Mt.2013.108  0.188
2003 Schneider BL, Aebischer P. Cellular implants: pioneers in xenotransplantation? Xenotransplantation. 10: 96-7. PMID 12588642 DOI: 10.1034/j.1399-3089.2003.02086.x  0.187
2006 Blanco-Bose WE, Schneider BL, Aebischer P. Inducing tolerance to a soluble foreign antigen by encapsulated cell transplants. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 447-56. PMID 16209937 DOI: 10.1016/J.Ymthe.2005.08.010  0.186
1992 McCormack ML, Goddard M, Guénard V, Aebischer P. Comparison of dorsal and ventral spinal root regeneration through semipermeable guidance channels. The Journal of Comparative Neurology. 313: 449-56. PMID 1770168 DOI: 10.1002/cne.903130305  0.186
2002 Régulier E, Pereira de Almeida L, Sommer B, Aebischer P, Déglon N. Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease. Human Gene Therapy. 13: 1981-90. PMID 12427308 DOI: 10.1089/10430340260355383  0.185
1999 Bensadoun JC, Mirochnitchenko O, Inouye M, Aebischer P, Zurn AD. Attenuation of 6-OHDA-induced neurotoxicity in glutathione peroxidase transgenic mice. The European Journal of Neuroscience. 10: 3231-6. PMID 9786216 DOI: 10.1046/j.1460-9568.1998.00345.x  0.183
1996 Borkenhagen M, Aebischer P. Tissue-Engineering Approaches for Central and Peripheral Nervous-System Regeneration Mrs Bulletin. 21: 59-61. DOI: 10.1557/S0883769400031869  0.179
2009 Dusonchet J, Bensadoun JC, Schneider BL, Aebischer P. Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease. Neurobiology of Disease. 35: 32-41. PMID 19348945 DOI: 10.1016/j.nbd.2009.03.013  0.178
2000 Mittoux V, Joseph JM, Conde F, Palfi S, Dautry C, Poyot T, Bloch J, Deglon N, Ouary S, Nimchinsky EA, Brouillet E, Hof PR, Peschanski M, Aebischer P, Hantraye P. Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease. Human Gene Therapy. 11: 1177-87. PMID 10834619 DOI: 10.1089/10430340050015220  0.178
2008 Bauer M, Szulc J, Meyer M, Jensen CH, Terki TA, Meixner A, Kinkl N, Gasser T, Aebischer P, Ueffing M. Delta-like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons. Journal of Neurochemistry. 104: 1101-15. PMID 17986227 DOI: 10.1111/j.1471-4159.2007.05037.x  0.175
2001 Rinsch C, Quinodoz P, Pittet B, Alizadeh N, Baetens D, Montandon D, Aebischer P, Pepper MS. Delivery of FGF-2 but not VEGF by encapsulated genetically engineered myoblasts improves survival and vascularization in a model of acute skin flap ischemia Gene Therapy. 8: 523-533. PMID 11319619 DOI: 10.1038/sj.gt.3301436  0.174
1996 Borkenhagen M, Clemence JF, Aebischer P. Development of a bioartificial synthetic extracellular matrix-equivalent for nerve regeneration Transactions of the Annual Meeting of the Society For Biomaterials in Conjunction With the International Biomaterials Symposium. 2: 229.  0.172
2000 Cisterni C, Henderson CE, Aebischer P, Pettmann B, Déglon N. Efficient gene transfer and expression of biologically active glial cell line-derived neurotrophic factor in rat motoneurons transduced wit lentiviral vectors. Journal of Neurochemistry. 74: 1820-8. PMID 10800924 DOI: 10.1046/j.1471-4159.2000.0741820.x  0.171
1996 Zurn AD, Winkel L, Menoud A, Djabali K, Aebischer P. Combined effects of GDNF, BDNF, and CNTF on motoneuron differentiation in vitro. Journal of Neuroscience Research. 44: 133-41. PMID 8723221 DOI: 10.1002/(SICI)1097-4547(19960415)44:2<133::AID-JNR5>3.0.CO;2-E  0.171
2004 Zala D, Bensadoun JC, Pereira de Almeida L, Leavitt BR, Gutekunst CA, Aebischer P, Hayden MR, Déglon N. Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice. Experimental Neurology. 185: 26-35. PMID 14697316 DOI: 10.1016/J.Expneurol.2003.09.002  0.171
2007 Schneider BL, Seehus CR, Capowski EE, Aebischer P, Zhang SC, Svendsen CN. Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation. Human Molecular Genetics. 16: 651-66. PMID 17309880 DOI: 10.1093/Hmg/Ddm008  0.17
2004 Lo Bianco C, Schneider BL, Bauer M, Sajadi A, Brice A, Iwatsubo T, Aebischer P. Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 17510-5. PMID 15576511 DOI: 10.1073/pnas.0405313101  0.17
2003 Schwenter F, Déglon N, Aebischer P. Optimization of human erythropoietin secretion from MLV-infected human primary fibroblasts used for encapsulated cell therapy. The Journal of Gene Medicine. 5: 246-57. PMID 12666190 DOI: 10.1002/jgm.338  0.17
1995 Xu XM, Guénard V, Kleitman N, Aebischer P, Bunge MB. A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord. Experimental Neurology. 134: 261-72. PMID 7556546 DOI: 10.1006/Exnr.1995.1056  0.17
1999 Bamber NI, Li H, Aebischer P, Xu XM. Fetal spinal cord tissue in mini-guidance channels promotes longitudinal axonal growth after grafting into hemisected adult rat spinal cords Neural Plasticity. 6: 103-121. DOI: 10.1155/NP.1999.103  0.169
2004 Lo Bianco C, Déglon N, Pralong W, Aebischer P. Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease. Neurobiology of Disease. 17: 283-9. PMID 15474365 DOI: 10.1016/j.nbd.2004.06.008  0.169
2016 Lathuilière A, Laversenne V, Astolfo A, Kopetzki E, Jacobsen H, Stampanoni M, Bohrmann B, Schneider BL, Aebischer P. A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies. Brain : a Journal of Neurology. PMID 26956423 DOI: 10.1093/brain/aww036  0.169
2013 Löw K, Aebischer P, Schneider BL. Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles. Human Gene Therapy. 24: 613-29. PMID 23600720 DOI: 10.1089/hum.2012.174  0.168
2001 Arsenijevic Y, Weiss S, Schneider B, Aebischer P. Insulin-like growth factor-1 is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibroblast growth factor-2 Journal of Neuroscience. 21: 7194-7202. PMID 11549730  0.167
2009 Emborg ME, Moirano J, Raschke J, Bondarenko V, Zufferey R, Peng S, Ebert AD, Joers V, Roitberg B, Holden JE, Koprich J, Lipton J, Kordower JH, Aebischer P. Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF. Neurobiology of Disease. 36: 303-11. PMID 19660547 DOI: 10.1016/J.Nbd.2009.07.022  0.165
2003 Régulier E, Trottier Y, Perrin V, Aebischer P, Déglon N. Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum. Human Molecular Genetics. 12: 2827-36. PMID 12952868 DOI: 10.1093/hmg/ddg305  0.164
2006 Pardo R, Colin E, Régulier E, Aebischer P, Déglon N, Humbert S, Saudou F. Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 1635-45. PMID 16452687 DOI: 10.1523/Jneurosci.3706-05.2006  0.163
1997 Pizzorusso T, Porciatti V, Tseng JL, Aebischer P, Maffei L. Transplant of polymer-encapsulated cells genetically engineered to release nerve growth factor allows a normal functional development of the visual cortex in dark-reared rats. Neuroscience. 80: 307-11. PMID 9284336 DOI: 10.1016/S0306-4522(97)00182-6  0.161
2006 Szulc J, Wiznerowicz M, Sauvain MO, Trono D, Aebischer P. A versatile tool for conditional gene expression and knockdown. Nature Methods. 3: 109-16. PMID 16432520 DOI: 10.1016/J.Ymthe.2006.08.383  0.16
2012 Fauvet B, Mbefo MK, Fares MB, Desobry C, Michael S, Ardah MT, Tsika E, Coune P, Prudent M, Lion N, Eliezer D, Moore DJ, Schneider B, Aebischer P, El-Agnaf OM, et al. α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer. The Journal of Biological Chemistry. 287: 15345-64. PMID 22315227 DOI: 10.1074/Jbc.M111.318949  0.157
2001 Bloch J, Fine EG, Bouche N, Zurn AD, Aebischer P. Nerve growth factor- and neurotrophin-3-releasing guidance channels promote regeneration of the transected rat dorsal root Experimental Neurology. 172: 425-432. PMID 11716566 DOI: 10.1006/exnr.2001.7778  0.155
2008 Runne H, Régulier E, Kuhn A, Zala D, Gokce O, Perrin V, Sick B, Aebischer P, Déglon N, Luthi-Carter R. Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 9723-31. PMID 18815258 DOI: 10.1523/Jneurosci.3044-08.2008  0.153
1998 Makohliso SA, Giovangrandi L, Léonard D, Mathieu HJ, Ilegems M, Aebischer P. Application of Teflon-AF® thin films for bio-patterning of neural cell adhesion Biosensors and Bioelectronics. 13: 1227-1235. PMID 9871978 DOI: 10.1016/S0956-5663(98)00036-0  0.151
2006 Arango M, Holbert S, Zala D, Brouillet E, Pearson J, Régulier E, Thakur AK, Aebischer P, Wetzel R, Déglon N, Néri C. CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 4649-59. PMID 16641246 DOI: 10.1523/Jneurosci.5409-05.2006  0.15
1995 Sagot Y, Dubois-Dauphin M, Tan S, de Bilbao F, Aebischer P, Martinou J, Kato A. Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease The Journal of Neuroscience. 15: 7727-7733. DOI: 10.1523/jneurosci.15-11-07727.1995  0.149
2014 Dirren E, Towne CL, Setola V, Redmond DE, Schneider BL, Aebischer P. Intracerebroventricular injection of adeno-associated virus 6 and 9 vectors for cell type-specific transgene expression in the spinal cord. Human Gene Therapy. 25: 109-20. PMID 24191919 DOI: 10.1089/hum.2013.021  0.148
2011 Towne C, Setola V, Schneider BL, Aebischer P. Neuroprotection by gene therapy targeting mutant SOD1 in individual pools of motor neurons does not translate into therapeutic benefit in fALS mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 274-83. PMID 21102563 DOI: 10.1038/mt.2010.260  0.147
1999 Xu XM, Zhang SX, Li H, Aebischer P, Bunge MB. Regrowth of axons into the distal spinal cord through a Schwann-cell-seeded mini-channel implanted into hemisected adult rat spinal cord. The European Journal of Neuroscience. 11: 1723-40. PMID 10215926 DOI: 10.1046/J.1460-9568.1999.00591.X  0.147
2013 Coune PG, Craveiro M, Gaugler MN, Mlynárik V, Schneider BL, Aebischer P, Gruetter R. An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker. Nmr in Biomedicine. 26: 43-50. PMID 22711560 DOI: 10.1002/Nbm.2817  0.144
2001 Emborg ME, Deglon N, Leventhal L, Aebischer P, Kordower JH. Viral vector-mediated gene therapy for Parkinson's disease Clinical Neuroscience Research. 1: 496-506. DOI: 10.1016/S1566-2772(01)00027-5  0.143
2010 Duplan L, Bernard N, Casseron W, Dudley K, Thouvenot E, Honnorat J, Rogemond V, De Bovis B, Aebischer P, Marin P, Raoul C, Henderson CE, Pettmann B. Collapsin response mediator protein 4a (CRMP4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron axonal degeneration and cell death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 785-96. PMID 20071543 DOI: 10.1523/Jneurosci.5411-09.2010  0.142
1997 Kato AC, Aebischer P. Gene therapies fob the central nervous system | Thérapies géniques pour le système nerveux central Medecine Et Hygiene. 55: 1536-1538.  0.142
2012 Ciron C, Lengacher S, Dusonchet J, Aebischer P, Schneider BL. Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function. Human Molecular Genetics. 21: 1861-76. PMID 22246294 DOI: 10.1093/hmg/ddr618  0.141
2011 Coune PG, Bensadoun JC, Aebischer P, Schneider BL. Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease. Journal of Parkinson's Disease. 1: 373-87. PMID 23939344 DOI: 10.3233/JPD-2011-11058  0.14
2003 Kostic C, Chiodini F, Salmon P, Wiznerowicz M, Deglon N, Hornfeld D, Trono D, Aebischer P, Schorderet DF, Munier FL, Arsenijevic Y. Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina. Gene Therapy. 10: 818-21. PMID 12704422 DOI: 10.1038/Sj.Gt.3301948  0.14
2012 Oueslati A, Paleologou KE, Schneider BL, Aebischer P, Lashuel HA. Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1536-44. PMID 22302797 DOI: 10.1523/Jneurosci.3784-11.2012  0.139
2002 Lo Bianco C, Ridet JL, Schneider BL, Deglon N, Aebischer P. alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 10813-8. PMID 12122208 DOI: 10.1073/pnas.152339799  0.136
2008 Szulc J, Aebischer P. Conditional gene expression and knockdown using lentivirus vectors encoding shRNA. Methods in Molecular Biology (Clifton, N.J.). 434: 291-309. PMID 18470652 DOI: 10.1007/978-1-60327-248-3_18  0.136
2005 Colin E, Régulier E, Perrin V, Dürr A, Brice A, Aebischer P, Déglon N, Humbert S, Saudou F. Akt is altered in an animal model of Huntington's disease and in patients. The European Journal of Neuroscience. 21: 1478-88. PMID 15845076 DOI: 10.1111/J.1460-9568.2005.03985.X  0.135
2016 Andrews MR, Soleman S, Cheah M, Tumbarello DA, Mason MR, Moloney E, Verhaagen J, Bensadoun JC, Schneider B, Aebischer P, Fawcett JW. Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent. Eneuro. 3. PMID 27570822 DOI: 10.1523/ENEURO.0029-16.2016  0.132
2004 Guillot S, Azzouz M, Déglon N, Zurn A, Aebischer P. Local GDNF expression mediated by lentiviral vector protects facial nerve motoneurons but not spinal motoneurons in SOD1(G93A) transgenic mice. Neurobiology of Disease. 16: 139-49. PMID 15207271 DOI: 10.1016/j.nbd.2004.01.017  0.13
2015 Mächler P, Wyss MT, Elsayed M, Stobart J, Gutierrez R, von Faber-Castell A, Kaelin V, Zuend M, San Martín A, Romero-Gómez I, Baeza-Lehnert F, Lengacher S, Schneider BL, Aebischer P, Magistretti PJ, et al. In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons. Cell Metabolism. PMID 26698914 DOI: 10.1016/J.Cmet.2015.10.010  0.13
2009 Chu Y, Dodiya H, Aebischer P, Olanow CW, Kordower JH. Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions. Neurobiology of Disease. 35: 385-98. PMID 19505575 DOI: 10.1016/J.Nbd.2009.05.023  0.128
2008 Schneider B, Zufferey R, Aebischer P. Viral vectors, animal models and new therapies for Parkinson's disease. Parkinsonism & Related Disorders. 14: S169-71. PMID 18585946 DOI: 10.1016/j.parkreldis.2008.04.024  0.128
1991 Aebischer P, Goddard M, Bergman H, Wichmann T, DeLong MR. Treating Parkinson's disease with lesions of the subthalamic nucleus Science. 252: 133-134. PMID 2011750 DOI: 10.1126/science.2011750  0.127
2016 Brys I, Bobela W, Schneider BL, Aebischer P, Fuentes R. Spinal cord stimulation improves forelimb use in an alpha-synuclein animal model of Parkinson's disease. The International Journal of Neuroscience. 1-9. PMID 26856727 DOI: 10.3109/00207454.2016.1138296  0.127
2001 Arsenijevic Y, Villemure JG, Brunet JF, Bloch JJ, Déglon N, Kostic C, Zurn A, Aebischer P. Isolation of multipotent neural precursors residing in the cortex of the adult human brain. Experimental Neurology. 170: 48-62. PMID 11421583 DOI: 10.1006/exnr.2001.7691  0.126
2000 Schense JC, Bloch J, Aebischer P, Hubbell JA. Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension Nature Biotechnology. 18: 415-419. PMID 10748522 DOI: 10.1038/74473  0.125
1986 AEBISCHER P, VALENTINI RF, WINN SR, KUNZ S, SASKEN H, GALLETTI PM. Regeneration of Transected Sciatic Nerves Through Semi-Permeable Nerve Guidance Channels Asaio Transactions. 32: 474-477. DOI: 10.1097/00002216-198609000-00017  0.122
2014 Aebischer P. Forword Industrial Scale Suspension Culture of Living Cells. v-vi.  0.12
2015 Lathuiliere A, Laversenne V, Astolfo A, Stampanoni M, Bohrmann B, Schneider BL, Aebischer P. O1-05-03: Preventive anti-Aß passive immunization using a subcutaneous cellular implant lowers brain amyloid burden and tau pathology Alzheimer's & Dementia. 11: P136-P136. DOI: 10.1016/j.jalz.2015.07.053  0.119
1983 Schultz W, Ruffieux A, Aebischer P. The activity of pars compacta neurons of the monkey substantia nigra in relation to motor activation Experimental Brain Research. 51. DOI: 10.1007/BF00237874  0.118
2010 Towne C, Schneider BL, Kieran D, Redmond DE, Aebischer P. Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6. Gene Therapy. 17: 141-6. PMID 19727139 DOI: 10.1038/gt.2009.119  0.118
2011 Dusonchet J, Kochubey O, Stafa K, Young SM, Zufferey R, Moore DJ, Schneider BL, Aebischer P. A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 907-12. PMID 21248115 DOI: 10.1523/Jneurosci.5092-10.2011  0.117
2009 Perrin V, Dufour N, Raoul C, Hassig R, Brouillet E, Aebischer P, Luthi-Carter R, Déglon N. Implication of the JNK pathway in a rat model of Huntington's disease. Experimental Neurology. 215: 191-200. PMID 19022249 DOI: 10.1016/J.Expneurol.2008.10.008  0.115
2000 Tseng JL, Aebischer P. Encapsulated neural transplants Progress in Brain Research. 127: 189-202. PMID 11142028 DOI: 10.1016/S0079-6123(00)27010-6  0.115
2001 Bamber NI, Li H, Lu X, Oudega M, Aebischer P, Xu XM. Neurotrophins BDNF and NT-3 promote axonal re-entry into the distal host spinal cord through Schwann cell-seeded mini-channels European Journal of Neuroscience. 13: 257-268. PMID 11168530 DOI: 10.1111/j.1460-9568.2001.01387.x  0.108
2007 Perrin V, Régulier E, Abbas-Terki T, Hassig R, Brouillet E, Aebischer P, Luthi-Carter R, Déglon N. Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 903-11. PMID 17375066 DOI: 10.1038/mt.sj.6300141  0.108
2006 Raoul C, Buhler E, Sadeghi C, Jacquier A, Aebischer P, Pettmann B, Henderson CE, Haase G. Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL. Proceedings of the National Academy of Sciences of the United States of America. 103: 6007-12. PMID 16581901 DOI: 10.1073/pnas.0508774103  0.108
2008 Towne C, Raoul C, Schneider BL, Aebischer P. Systemic AAV6 delivery mediating RNA interference against SOD1: neuromuscular transduction does not alter disease progression in fALS mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1018-25. PMID 18414477 DOI: 10.1038/mt.2008.73  0.106
2009 Mastroeni R, Bensadoun JC, Charvin D, Aebischer P, Pujol A, Raoul C. Insulin-like growth factor-1 and neurotrophin-3 gene therapy prevents motor decline in an X-linked adrenoleukodystrophy mouse model. Annals of Neurology. 66: 117-22. PMID 19670442 DOI: 10.1002/ana.21677  0.105
2015 Bobela W, Aebischer P, Schneider BL. Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease. Biomolecules. 5: 2675-700. PMID 26501339 DOI: 10.3390/biom5042675  0.105
2000 Azzouz M, Hottinger A, Paterna JC, Zurn AD, Aebischer P, Büeler H. Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2 Human Molecular Genetics. 9: 803-811. PMID 10749988  0.104
2001 Aebischer P, Ridet JL. Recombinant proteins for neurodegenerative diseases: The delivery issue Trends in Neurosciences. 24: 533-540. PMID 11506887 DOI: 10.1016/S0166-2236(00)01899-3  0.104
2015 Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR. Tmc gene therapy restores auditory function in deaf mice. Science Translational Medicine. 7: 295ra108. PMID 26157030 DOI: 10.1126/Scitranslmed.Aab1996  0.102
2002 Abbas-Terki T, Blanco-Bose W, Déglon N, Pralong W, Aebischer P. Lentiviral-mediated RNA interference. Human Gene Therapy. 13: 2197-201. PMID 12542850 DOI: 10.1089/104303402320987888  0.102
2002 Rinsch C, Dupraz P, Schneider BL, Déglon N, Maxwell PH, Ratcliffe PJ, Aebischer P. Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia. Kidney International. 62: 1395-401. PMID 12234311 DOI: 10.1111/J.1523-1755.2002.Kid574.X  0.101
2002 Boison D, Huber A, Padrun V, Déglon N, Aebischer P, Möhler H. Seizure suppression by adenosine-releasing cells is independent of seizure frequency. Epilepsia. 43: 788-96. PMID 12180995 DOI: 10.1046/J.1528-1157.2002.33001.X  0.1
1997 Hottinger AF, Fine EG, Gurney ME, Zurn AD, Aebischer P. The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis. The European Journal of Neuroscience. 9: 1548-51. PMID 9240414 DOI: 10.1111/j.1460-9568.1997.tb01511.x  0.1
2009 Towne C, Aebischer P. Lentiviral and adeno-associated vector-based therapy for motor neuron disease through RNAi. Methods in Molecular Biology (Clifton, N.J.). 555: 87-108. PMID 19495690 DOI: 10.1007/978-1-60327-295-7_7  0.096
2009 Azeredo da Silveira S, Schneider BL, Cifuentes-Diaz C, Sage D, Abbas-Terki T, Iwatsubo T, Unser M, Aebischer P. Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease. Human Molecular Genetics. 18: 872-87. PMID 19074459 DOI: 10.1093/Hmg/Ddn417  0.095
2014 Kaplan A, Spiller KJ, Towne C, Kanning KC, Choe GT, Geber A, Akay T, Aebischer P, Henderson CE. Neuronal matrix metalloproteinase-9 is a determinant of selective neurodegeneration. Neuron. 81: 333-48. PMID 24462097 DOI: 10.1016/J.Neuron.2013.12.009  0.095
2013 Oueslati A, Schneider BL, Aebischer P, Lashuel HA. Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 110: E3945-54. PMID 23983262 DOI: 10.1073/Pnas.1309991110  0.094
2007 Palfi S, Brouillet E, Jarraya B, Bloch J, Jan C, Shin M, Condé F, Li XJ, Aebischer P, Hantraye P, Déglon N. Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1444-51. PMID 17505477 DOI: 10.1038/Sj.Mt.6300185  0.094
2001 Bensadoun JC, Pereira de Almeida L, Dréano M, Aebischer P, Déglon N. Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome European Journal of Neuroscience. 14: 1753-1761. PMID 11860469 DOI: 10.1046/j.0953-816X.2001.01802.x  0.093
2012 Coune PG, Schneider BL, Aebischer P. Parkinson's disease: gene therapies. Cold Spring Harbor Perspectives in Medicine. 2: a009431. PMID 22474617 DOI: 10.1101/cshperspect.a009431  0.092
2013 Dassie E, Andrews MR, Bensadoun JC, Cacquevel M, Schneider BL, Aebischer P, Wouters FS, Richardson JC, Hussain I, Howlett DR, Spillantini MG, Fawcett JW. Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model. Neurobiology of Aging. 34: 1355-68. PMID 23273572 DOI: 10.1016/J.Neurobiolaging.2012.11.011  0.092
2022 Rochat C, Bernard-Marissal N, Källstig E, Pradervand S, Perrin FE, Aebischer P, Raoul C, Schneider BL. Astrocyte-targeting RNA interference against mutated superoxide dismutase 1 induces motoneuron plasticity and protects fast-fatigable motor units in a mouse model of amyotrophic lateral sclerosis. Glia. PMID 34978340 DOI: 10.1002/glia.24140  0.091
2018 Lei H, Dirren E, Poitry-Yamate C, Schneider BL, Gruetter R, Aebischer P. Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X18756499. PMID 29400109 DOI: 10.1177/0271678X18756499  0.091
2009 McDonald A, Marone F, Hintermüller C, J-C Bensadoun, Aebischer P, Stampanoni M. High-throughput, high-resolution X-ray phase contrast tomographic microscopy for visualisation of soft tissue Journal of Physics: Conference Series. 186. DOI: 10.1088/1742-6596/186/1/012043  0.091
1999 Makohliso SA, Léonard D, Giovangrandi L, Mathieu HJ, Ilegems M, Aebischer P. Surface characterization of a biochip prototype for cell-based biosensor applications Langmuir. 15: 2940-2946. DOI: 10.1021/la980688h  0.09
2006 Bensadoun JC, Aebischer P. Viral vectors as a tool to model and treat Parkinson's disease. Wiener Klinische Wochenschrift. 118: 568-70. PMID 17136329 DOI: 10.1007/s00508-006-0736-5  0.089
1999 Aebischer P, Hottinger AF, Deglon N. Cellular xenotransplantation [1] Nature Medicine. 5: 852. PMID 10426290 DOI: 10.1038/11271  0.089
2005 Raoul C, Abbas-Terki T, Bensadoun JC, Guillot S, Haase G, Szulc J, Henderson CE, Aebischer P. Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. Nature Medicine. 11: 423-8. PMID 15768028 DOI: 10.1038/nm1207  0.088
2006 Raoul C, Barker SD, Aebischer P. Viral-based modelling and correction of neurodegenerative diseases by RNA interference. Gene Therapy. 13: 487-95. PMID 16319945 DOI: 10.1038/sj.gt.3302690  0.088
2004 Régulier E, Zala D, Aebischer P, Déglon N. Lentiviral-mediated gene transfer to model triplet repeat disorders. Methods in Molecular Biology (Clifton, N.J.). 277: 199-213. PMID 15201458 DOI: 10.1385/1-59259-804-8:199  0.085
2009 Blockeel C, Mock P, Verheyen G, Bouche N, Le Goff P, Heyman Y, Wrenzycki C, Höffmann K, Niemann H, Haentjens P, de Los Santos MJ, Fernandez-Sanchez M, Velasco M, Aebischer P, Devroey P, et al. An in vivo culture system for human embryos using an encapsulation technology: a pilot study. Human Reproduction (Oxford, England). 24: 790-6. PMID 19273881 DOI: 10.1093/humrep/dep005  0.083
2007 Wiznerowicz M, Jakobsson J, Szulc J, Liao S, Quazzola A, Beermann F, Aebischer P, Trono D. The Kruppel-associated box repressor domain can trigger de novo promoter methylation during mouse early embryogenesis. The Journal of Biological Chemistry. 282: 34535-41. PMID 17893143 DOI: 10.1074/Jbc.M705898200  0.082
2017 Zheng L, Bernard-Marissal N, Moullan N, D'Amico D, Auwerx J, Moore DJ, Knott G, Aebischer P, Schneider BL. Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons. Human Molecular Genetics. PMID 28053050 DOI: 10.1093/hmg/ddw418  0.082
2012 Löw K, Aebischer P. Use of viral vectors to create animal models for Parkinson's disease. Neurobiology of Disease. 48: 189-201. PMID 22227451 DOI: 10.1016/j.nbd.2011.12.038  0.082
2010 Langou K, Moumen A, Pellegrino C, Aebischer J, Medina I, Aebischer P, Raoul C. AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway. Journal of Neurochemistry. 114: 795-809. PMID 20477942 DOI: 10.1111/j.1471-4159.2010.06806.x  0.082
2002 Déglon N, Aebischer P. Lentiviruses as vectors for CNS diseases Current Topics in Microbiology and Immunology. 261: 191-209. PMID 11892248  0.08
2008 Lo Bianco C, Shorter J, Régulier E, Lashuel H, Iwatsubo T, Lindquist S, Aebischer P. Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. The Journal of Clinical Investigation. 118: 3087-97. PMID 18704197 DOI: 10.1172/Jci35781  0.079
2010 Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, et al. Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3184-98. PMID 20203178 DOI: 10.1523/Jneurosci.5922-09.2010  0.079
2009 Towne C, Pertin M, Beggah AT, Aebischer P, Decosterd I. Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery. Molecular Pain. 5: 52. PMID 19737386 DOI: 10.1186/1744-8069-5-52  0.078
2014 Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY, Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu L, Schneider BL, Aebischer P, et al. A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity. Human Molecular Genetics. 23: 4887-905. PMID 24794857 DOI: 10.1093/Hmg/Ddu202  0.078
2015 Yang S, Cacquevel M, Saksida LM, Bussey TJ, Schneider BL, Aebischer P, Melani R, Pizzorusso T, Fawcett JW, Spillantini MG. Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology. Experimental Neurology. 265: 48-58. PMID 25483398 DOI: 10.1016/J.Expneurol.2014.11.013  0.078
2009 Pertin M, Towne C, Beggah A, Aebischer P, Decosterd I. 229 EFFICACY AND SPECIFICITY OF RECOMBINANT ADENO-ASSOCIATED VIRUS SEROTYPE 6 MEDIATED GENE TRANSFER TO DRG NEURONS THROUGH DIFFERENT ROUTES OF DELIVERY European Journal of Pain. 13: S74. DOI: 10.1016/S1090-3801(09)60232-9  0.072
2011 Cacquevel M, Schneider B, Aebischer P, Aebi A, Colin P, Padrun V, Pidoux F. P1-035: Modelling Alzheimer's disease through Adeno-Associated Virus (AAV) vector gene delivery in the mouse brain Alzheimer's & Dementia. 7: S121-S122. DOI: 10.1016/j.jalz.2011.05.315  0.071
2013 Lathuilière A, Papin S, Cacquevel M, Paganetti P, Muhs A, Knott G, Schneider B, Aebischer P. Deciphering the role of tau in neurodegeneration using Adeno-Associated Viral (AAV) vectors to express human tau in the mouse forebrain Molecular Neurodegeneration. 8. DOI: 10.1186/1750-1326-8-S1-P27  0.071
2012 Mlynárik V, Cacquevel M, Sun-Reimer L, Janssens S, Cudalbu C, Lei H, Schneider BL, Aebischer P, Gruetter R. Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 31: S87-99. PMID 22451319 DOI: 10.3233/Jad-2012-112072  0.071
2008 Schneider BL, Gaugler MN, Aebischer P. Viral Vectors. A Potent Approach to Generate Genetic Models of Parkinson's Disease Parkinson's Disease. 269-284. DOI: 10.1016/B978-0-12-374028-1.00020-8  0.071
1998 Zurn AD, Tseng JL, Déglon N, Joseph JM, Aebischer P. A gene therapy approach for the treatment of amyotrophic lateral sclerosis and Parkinson's disease Advances in Pharmacology (San Diego, Calif.). 42: 929-931. PMID 9328050 DOI: 10.1016/S1054-3589(08)60899-6  0.068
2001 Kordower JH, Aebischer P. Gene therapy to the rescue in Parkinson's disease: Response from Kordower and Aebischer Trends in Pharmacological Sciences. 22: 105-106. PMID 11239562 DOI: 10.1016/S0165-6147(00)01637-0  0.068
2016 Ryu D, Mouchiroud L, Andreux PA, Katsyuba E, Moullan N, Nicolet-Dit-Félix AA, Williams EG, Jha P, Lo Sasso G, Huzard D, Aebischer P, Sandi C, Rinsch C, Auwerx J. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine. PMID 27400265 DOI: 10.1038/Nm.4132  0.063
2003 Aebischer P, Pralong W. Gene therapy approaches for Parkinson's disease Journal of Neurochemistry. 85: 8-8. DOI: 10.1046/j.1471-4159.85.s2.8_3.x  0.062
2011 Aebischer P. Marlowe in the movies Christopher Marlowe in Context. 316-324. DOI: 10.1017/CBO9781139060882.034  0.057
2017 Bobela W, Nazeeruddin S, Knott G, Aebischer P, Schneider BL. Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity. Molecular Neurodegeneration. 12: 80. PMID 29100525 DOI: 10.1186/s13024-017-0220-x  0.056
2012 Pinzer BR, Cacquevel M, Modregger P, McDonald SA, Bensadoun JC, Thuering T, Aebischer P, Stampanoni M. Imaging brain amyloid deposition using grating-based differential phase contrast tomography. Neuroimage. 61: 1336-46. PMID 22450300 DOI: 10.1016/j.neuroimage.2012.03.029  0.056
1996 Sagot Y, Tan S, Hammang J, Aebischer P, Kato A. GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice The Journal of Neuroscience. 16: 2335-2341. DOI: 10.1523/jneurosci.16-07-02335.1996  0.056
1999 Fitting JW, Paillex R, Hirt L, Aebischer P, Schluep M. Sniff nasal pressure: A sensitive respiratory test to assess progression of amyotrophic lateral sclerosis Annals of Neurology. 46: 887-893. PMID 10589541 DOI: 10.1002/1531-8249(199912)46:6<887::AID-ANA11>3.0.CO;2-L  0.054
2018 Singh A, Andreux P, Blanco-Bose W, Aebischer P, Auwerx J, Rinsch C. TRANSLATING UROLITHIN A BENEFITS ON MUSCLE MITOCHONDRIA TO HUMANS Innovation in Aging. 2: 92-93. DOI: 10.1093/Geroni/Igy023.351  0.053
2015 Dirren E, Aebischer J, Rochat C, Towne C, Schneider BL, Aebischer P. SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice. Annals of Clinical and Translational Neurology. 2: 167-84. PMID 25750921 DOI: 10.1002/acn3.162  0.05
2007 Aebischer P. Growing up with Shakespeare: The terry family memoirs Shakespeare and Childhood. 169-183. DOI: 10.1017/CBO9780511483493.011  0.049
2016 Bobela-Aebischer J, Rochat C, Bernard-Marissal N, Aebischer P, Schneider BL. 606. Use of a Bicistronic Vector to Silence SOD1 in Motoneurons and Astrocytes for the Treatment of Familial Amyotrophic Lateral Sclerosis Molecular Therapy. 24: S240. DOI: 10.1016/S1525-0016(16)33414-1  0.048
2015 Aebischer P. Shakespeare with a Difference: Dismembering and Remembering Titus Andronicus in Heiner Müller's and Brigitte Maria Mayer's Anatomie Titus A Concise Companion to the Study of Manuscripts, Printed Books, and the Production of Early Modern Texts: a Festschrift For Gordon Campbell. 322-345. DOI: 10.1002/9781118635261.ch16  0.048
2007 Aebischer P, Kato AC. Playng defense against Lou Gehrig's disease. Scientific American. 297: 86-93. PMID 17990828  0.045
2011 Aebischer P. Screening early modern drama: Beyond Shakespeare Screening Early Modern Drama: Beyond Shakespeare. 1-274. DOI: 10.1017/CBO9781139176194  0.045
1999 Aebischer P. GENE TRANSFER APPROACHES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES Biochemical Society Transactions. 27: A138-A138. DOI: 10.1042/bst027a138a  0.043
2012 Lathuilière A, Cacquevel M, Schneider B, Aebischer P. P3-002: Overexpression of tau in the mouse forebrain using adeno-associated virus (AAV) leads to tau hyperphosphorylation, formation of neurofibrillary tangles and neurodegeneration Alzheimer's & Dementia. 8: P457-P457. DOI: 10.1016/j.jalz.2012.05.1220  0.043
2019 Andreux PA, Blanco-Bose W, Ryu D, Burdet F, Ibberson M, Aebischer P, Auwerx J, Singh A, Rinsch C. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature Metabolism. 1: 595-603. PMID 32694802 DOI: 10.1038/s42255-019-0073-4  0.04
2004 Raoul C, Aebischer P. ALS, IGF-1 and gene therapy: 'It's never too late to mend' Gene Therapy. 11: 429-430. DOI: 10.1038/sj.gt.3302204  0.04
2015 Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR. Tmc gene therapy restores auditory function in deaf mice Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aab1996  0.04
2011 Cacquevel M, Aebischer P, Aebi A, Colin P, Padrun V, Pidoux F, Schneider B. P1-036: Behavioral and neuropathological characterization of a viral-based model of amyloid pathology Alzheimer's & Dementia. 7: S122-S122. DOI: 10.1016/j.jalz.2011.05.316  0.039
2009 Barde I, Laurenti E, Verp S, Groner AC, Towne C, Padrun V, Aebischer P, Trumpp A, Trono D. Regulation of episomal gene expression by KRAB/KAP1-mediated histone modifications. Journal of Virology. 83: 5574-80. PMID 19279087 DOI: 10.1128/Jvi.00001-09  0.034
2021 Singh A, D'Amico D, Andreux PA, Dunngalvin G, Kern T, Blanco-Bose W, Auwerx J, Aebischer P, Rinsch C. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. European Journal of Clinical Nutrition. PMID 34117375 DOI: 10.1038/s41430-021-00950-1  0.031
2017 Singh A, Andreux P, Blanco-Bose W, Ryu D, Aebischer P, Auwerx J, Rinsch C. ORALLY ADMINISTERED UROLITHIN A IS SAFE AND MODULATES MUSCLE AND MITOCHONDRIAL BIOMARKERS IN ELDERLY Innovation in Aging. 1: 1223-1224. DOI: 10.1093/Geroni/Igx004.4446  0.03
2022 Singh A, D'Amico D, Andreux PA, Fouassier AM, Blanco-Bose W, Evans M, Aebischer P, Auwerx J, Rinsch C. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports. Medicine. 3: 100633. PMID 35584623 DOI: 10.1016/j.xcrm.2022.100633  0.029
2014 Escher G, Noukakis D, Aebischer P. Boosting higher education in Africa through shared massive open online courses (MOOCs) Education, Learning, Training: Critical Issues For Development. 195-215. DOI: 10.1163/9789004281158_011  0.029
2022 Liu S, D'Amico D, Shankland E, Bhayana S, Garcia JM, Aebischer P, Rinsch C, Singh A, Marcinek DJ. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. Jama Network Open. 5: e2144279. PMID 35050355 DOI: 10.1001/jamanetworkopen.2021.44279  0.025
2019 Andreux PA, Blanco-Bose W, Ryu D, Burdet F, Ibberson M, Aebischer P, Auwerx J, Singh A, Rinsch C. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans Nature Metabolism. 1: 595-603. DOI: 10.1038/s42255-019-0073-4  0.025
2003 Aebischer P. Creative disability/disabled creativity in Henry Green's blindness (1926) Studies in the Novel. 35.  0.024
2009 Aebischer P, Prince K. Performing early modern drama today Performing Early Modern Drama Today. 1-247. DOI: 10.1017/CBO9781139047975  0.024
2004 Zufferey R, Aebischer P. Salivary glands and gene therapy: the mouth waters. Gene Therapy. 11: 1425-6. PMID 15269715 DOI: 10.1038/sj.gt.3302321  0.022
1996 Heyd D, Aebischer P. Les facteurs neurotrophiques et leurs applications thérapeutiques potentielles MéDecine/Sciences. 12: 299. DOI: 10.4267/10608/732  0.022
2010 Aebischer P. Renaissance tragedy on film: Defying mainstream Shakespeare The Cambridge Companion to: English Renaissance Tragedy. 116-131. DOI: 10.1017/CCOL9780521519373.009  0.018
2012 Aebischer P. Philanthropy: The price of charity. Nature. 481: 260. PMID 22258589 DOI: 10.1038/481260a  0.01
2009 Aebischer P. Shakespearean heritage and the preposterous "Contemporary Jacobean" film: Mike Figgis's hotel Shakespeare Quarterly. 60: 279-303. DOI: 10.1353/shq.0.0088  0.01
2008 Aebischer P. Gender Studies: Shakespeare, Sex, and Violence: Negotiating Masculinities in Branagh 's Henry V and Taymor's Titus A Concise Companion to Shakespeare On Screen. 112-132. DOI: 10.1002/9780470757659.ch6  0.01
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