Emmanuel J. Botzolakis, MD PhD - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Ion Channels, Kinetic Modeling, Receptor Assembly, Receptor Trafficking

13 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Botzolakis EJ, Gurba KN, Lagrange AH, Feng HJ, Stanic AK, Hu N, Macdonald RL. Comparison of GABA-A Receptor αβγ and αβδ Expression Using Flow Cytometry and Electrophysiology: Evidence for Alternate Subunit Stoichiometries and Arrangements. The Journal of Biological Chemistry. PMID 27493204 DOI: 10.1074/Jbc.M115.698860  0.675
2014 Todd E, Gurba KN, Botzolakis EJ, Stanic AK, Macdonald RL. GABAA receptor biogenesis is impaired by the γ2 subunit febrile seizure-associated mutation, GABRG2(R177G). Neurobiology of Disease. 69: 215-24. PMID 24874541 DOI: 10.1016/j.nbd.2014.05.013  0.706
2011 Botzolakis EJ, Zhao J, Gurba KN, Macdonald RL, Hedera P. The effect of HSP-causing mutations in SPG3A and NIPA1 on the assembly, trafficking, and interaction between atlastin-1 and NIPA1. Molecular and Cellular Neurosciences. 46: 122-35. PMID 20816793 DOI: 10.1016/j.mcn.2010.08.012  0.657
2010 Ding L, Feng HJ, Macdonald RL, Botzolakis EJ, Hu N, Gallagher MJ. GABA(A) receptor alpha1 subunit mutation A322D associated with autosomal dominant juvenile myoclonic epilepsy reduces the expression and alters the composition of wild type GABA(A) receptors. The Journal of Biological Chemistry. 285: 26390-405. PMID 20551311 DOI: 10.1074/Jbc.M110.142299  0.6
2010 Bianchi MT, Botzolakis EJ. Targeting ligand-gated ion channels in neurology and psychiatry: is pharmacological promiscuity an obstacle or an opportunity? Bmc Pharmacology. 10: 3. PMID 20196850 DOI: 10.1186/1471-2210-10-3  0.559
2010 Macdonald RL, Botzolakis EJ. GABAA receptor channels Physiology and Pathology of Chloride Transporters and Channels in the Nervous System. 257-282. DOI: 10.1016/B978-0-12-374373-2.00014-5  0.474
2009 Bianchi MT, Botzolakis EJ, Lagrange AH, Macdonald RL. Benzodiazepine modulation of GABA(A) receptor opening frequency depends on activation context: a patch clamp and simulation study. Epilepsy Research. 85: 212-20. PMID 19447010 DOI: 10.1016/j.eplepsyres.2009.03.007  0.679
2009 Botzolakis EJ, Maheshwari A, Feng HJ, Lagrange AH, Shaver JH, Kassebaum NJ, Venkataraman R, Baudenbacher F, Macdonald RL. Achieving synaptically relevant pulses of neurotransmitter using PDMS microfluidics. Journal of Neuroscience Methods. 177: 294-302. PMID 19013195 DOI: 10.1016/j.jneumeth.2008.10.014  0.525
2009 Feng HJ, Botzolakis EJ, Macdonald RL. Context-dependent modulation of alphabetagamma and alphabetadelta GABA A receptors by penicillin: implications for phasic and tonic inhibition. Neuropharmacology. 56: 161-73. PMID 18775733 DOI: 10.1016/J.Neuropharm.2008.08.010  0.613
2008 Zhao J, Matthies DS, Botzolakis EJ, Macdonald RL, Blakely RD, Hedera P. Hereditary spastic paraplegia-associated mutations in the NIPA1 gene and its Caenorhabditis elegans homolog trigger neural degeneration in vitro and in vivo through a gain-of-function mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13938-51. PMID 19091982 DOI: 10.1523/JNEUROSCI.4668-08.2008  0.53
2008 Lo WY, Botzolakis EJ, Tang X, Macdonald RL. A conserved Cys-loop receptor aspartate residue in the M3-M4 cytoplasmic loop is required for GABAA receptor assembly. The Journal of Biological Chemistry. 283: 29740-52. PMID 18723504 DOI: 10.1074/Jbc.M802856200  0.645
2007 Bianchi MT, Botzolakis EJ, Haas KF, Fisher JL, Macdonald RL. Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABAA receptor desensitization and deactivation. The Journal of Physiology. 584: 769-87. PMID 17884921 DOI: 10.1113/jphysiol.2007.142364  0.708
2007 Lagrange AH, Botzolakis EJ, Macdonald RL. Enhanced macroscopic desensitization shapes the response of alpha4 subtype-containing GABAA receptors to synaptic and extrasynaptic GABA. The Journal of Physiology. 578: 655-76. PMID 17124266 DOI: 10.1113/jphysiol.2006.122135  0.611
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