Nancy Ratner - Publications

Affiliations: 
University of Cincinnati, Cincinnati, OH 
Area:
Schwann cell development

127 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Haworth KB, Arnold MA, Pierson CR, Choi K, Yeager ND, Ratner N, Roberts RD, Finlay JL, Cripe TP. Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: implications for immunotherapy. Oncotarget. 8: 82037-82048. PMID 29137242 DOI: 10.18632/oncotarget.18301  0.48
2017 Maertens O, McCurrach ME, Braun BS, De Raedt T, Epstein I, Huang TQ, Lauchle JO, Lee H, Wu J, Cripe TP, Clapp DW, Ratner N, Shannon K, Cichowski K. A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies. Cancer Research. PMID 28993414 DOI: 10.1158/0008-5472.CAN-17-1789  0.48
2017 Haworth KB, Arnold MA, Pierson CR, Choi K, Yeager ND, Ratner N, Roberts RD, Finlay JL, Cripe TP. Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: Implications for immunotherapy. Oncotarget. PMID 28611304 DOI: 10.18632/oncotarget.18301  0.48
2017 Currier MA, Sprague L, Rizvi TA, Nartker B, Chen CY, Wang PY, Hutzen BJ, Franczek MR, Patel AV, Chaney KE, Streby KA, Ecsedy JA, Conner J, Ratner N, Cripe TP. Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation. Oncotarget. PMID 28147331 DOI: 10.18632/oncotarget.14885  0.48
2016 Kendall JJ, Chaney KE, Patel AV, Rizvi TA, Largaespada DA, Ratner N. CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin. Oncotarget. PMID 27448963 DOI: 10.18632/oncotarget.10668  1
2016 Wu J, Keng V, Patmore DM, Kendall JJ, Patel AV, Jousma E, Jessen WJ, Choi K, Tschida BR, Silverstein KA, Fan D, Schwartz EB, Fuchs JR, Zou Y, Kim MO, ... ... Ratner N, et al. Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation. Cell Reports. PMID 26904939 DOI: 10.1016/j.celrep.2016.01.074  1
2015 Eiymo Mwa Mpollo MS, Brandt EB, Shanmukhappa SK, Arumugam PI, Tiwari S, Loberg A, Pillis D, Rizvi T, Lindsey M, Jonck B, Carmeliet P, Kalra VK, Le Cras TD, Ratner N, Wills-Karp M, et al. Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13. The Journal of Clinical Investigation. PMID 26690703 DOI: 10.1172/JCI77250  1
2015 Patel AV, Johansson G, Colbert MC, Dasgupta B, Ratner N. Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors. Neuro-Oncology. PMID 26116612 DOI: 10.1093/neuonc/nov076  1
2015 Jousma E, Rizvi TA, Wu J, Janhofer D, Dombi E, Dunn RS, Kim MO, Masters AR, Jones DR, Cripe TP, Ratner N. Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1. Pediatric Blood & Cancer. PMID 25907661 DOI: 10.1002/pbc.25546  1
2015 Ratner N, Miller SJ. A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor. Nature Reviews. Cancer. 15: 290-301. PMID 25877329 DOI: 10.1038/nrc3911  1
2015 Rauen KA, Huson SM, Burkitt-Wright E, Evans DG, Farschtschi S, Ferner RE, Gutmann DH, Hanemann CO, Kerr B, Legius E, Parada LF, Patton M, Peltonen J, Ratner N, Riccardi VM, et al. Recent developments in neurofibromatoses and RASopathies: management, diagnosis and current and future therapeutic avenues. American Journal of Medical Genetics. Part A. 167: 1-10. PMID 25393061 DOI: 10.1002/ajmg.a.36793  1
2014 Pooya S, Liu X, Kumar VB, Anderson J, Imai F, Zhang W, Ciraolo G, Ratner N, Setchell KD, Yoshida Y, Yutaka Y, Jankowski MP, Dasgupta B. The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism. Nature Communications. 5: 4993. PMID 25256100 DOI: 10.1038/ncomms5993  1
2014 Rahrmann EP, Moriarity BS, Otto GM, Watson AL, Choi K, Collins MH, Wallace M, Webber BR, Forster CL, Rizzardi AE, Schmechel SC, Ratner N, Largaespada DA. Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis. The American Journal of Pathology. 184: 2082-98. PMID 24832557 DOI: 10.1016/j.ajpath.2014.04.006  1
2014 Watson AL, Anderson LK, Greeley AD, Keng VW, Rahrmann EP, Halfond AL, Powell NM, Collins MH, Rizvi T, Moertel CL, Ratner N, Largaespada DA. Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity. Oncotarget. 5: 1502-14. PMID 24681606  1
2014 Ehrman LA, Nardini D, Ehrman S, Rizvi TA, Gulick J, Krenz M, Dasgupta B, Robbins J, Ratner N, Nakafuku M, Waclaw RR. The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3767-78. PMID 24599474 DOI: 10.1523/JNEUROSCI.3515-13.2014  1
2014 Brundage ME, Tandon P, Eaves DW, Williams JP, Miller SJ, Hennigan RH, Jegga A, Cripe TP, Ratner N. MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1. Oncogene. 33: 5626-36. PMID 24509877 DOI: 10.1038/onc.2013.506  1
2014 Widemann BC, Acosta MT, Ammoun S, Belzberg AJ, Bernards A, Blakeley J, Bretscher A, Cichowski K, Clapp DW, Dombi E, Evans GD, Ferner R, Fernandez-Valle C, Fisher MJ, Giovannini M, ... ... Ratner N, et al. CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies. American Journal of Medical Genetics. Part A. 164: 563-78. PMID 24443315 DOI: 10.1002/ajmg.a.36312  1
2014 Wu J, Patmore DM, Jousma E, Eaves DW, Breving K, Patel AV, Schwartz EB, Fuchs JR, Cripe TP, Stemmer-Rachamimov AO, Ratner N. EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors. Oncogene. 33: 173-80. PMID 23318430 DOI: 10.1038/onc.2012.579  1
2013 Guo L, Lee AA, Rizvi TA, Ratner N, Kirschner LS. The protein kinase A regulatory subunit R1A (Prkar1a) plays critical roles in peripheral nerve development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 17967-75. PMID 24227708 DOI: 10.1523/JNEUROSCI.0766-13.2013  1
2013 Mayes DA, Rizvi TA, Titus-Mitchell H, Oberst R, Ciraolo GM, Vorhees CV, Robinson AP, Miller SD, Cancelas JA, Stemmer-Rachamimov AO, Ratner N. Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature. Cell Reports. 4: 1197-212. PMID 24035394 DOI: 10.1016/j.celrep.2013.08.011  1
2013 Guo L, Moon C, Zheng Y, Ratner N. Cdc42 regulates Schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling. Glia. 61: 1906-21. PMID 24014231 DOI: 10.1002/glia.22567  1
2013 Rahrmann EP, Watson AL, Keng VW, Choi K, Moriarity BS, Beckmann DA, Wolf NK, Sarver A, Collins MH, Moertel CL, Wallace MR, Gel B, Serra E, Ratner N, Largaespada DA. Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis. Nature Genetics. 45: 756-66. PMID 23685747 DOI: 10.1038/ng.2641  1
2013 Watson AL, Rahrmann EP, Moriarity BS, Choi K, Conboy CB, Greeley AD, Halfond AL, Anderson LK, Wahl BR, Keng VW, Rizzardi AE, Forster CL, Collins MH, Sarver AL, Wallace MR, ... ... Ratner N, et al. Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance. Cancer Discovery. 3: 674-89. PMID 23535903 DOI: 10.1158/2159-8290.CD-13-0081  1
2013 Largaespada D, Ratner N. Interweaving the strands: β-catenin, an HIV co-receptor, and Schwann cell tumors. Cancer Cell. 23: 269-71. PMID 23518344 DOI: 10.1016/j.ccr.2013.03.001  1
2013 Plotkin SR, Blakeley JO, Evans DG, Hanemann CO, Hulsebos TJ, Hunter-Schaedle K, Kalpana GV, Korf B, Messiaen L, Papi L, Ratner N, Sherman LS, Smith MJ, Stemmer-Rachamimov AO, Vitte J, et al. Update from the 2011 International Schwannomatosis Workshop: From genetics to diagnostic criteria. American Journal of Medical Genetics. Part A. 161: 405-16. PMID 23401320 DOI: 10.1002/ajmg.a.35760  1
2013 Jessen WJ, Miller SJ, Jousma E, Wu J, Rizvi TA, Brundage ME, Eaves D, Widemann B, Kim MO, Dombi E, Sabo J, Hardiman Dudley A, Niwa-Kawakita M, Page GP, Giovannini M, ... ... Ratner N, et al. MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. The Journal of Clinical Investigation. 123: 340-7. PMID 23221341 DOI: 10.1172/JCI60578  1
2013 Prada CE, Jousma E, Rizvi TA, Wu J, Dunn RS, Mayes DA, Cancelas JA, Dombi E, Kim MO, West BL, Bollag G, Ratner N. Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition. Acta Neuropathologica. 125: 159-68. PMID 23099891 DOI: 10.1007/s00401-012-1056-7  1
2013 Hennigan RF, Moon CA, Parysek LM, Monk KR, Morfini G, Berth S, Brady S, Ratner N. The NF2 tumor suppressor regulates microtubule-based vesicle trafficking via a novel Rac, MLK and p38(SAPK) pathway. Oncogene. 32: 1135-43. PMID 22525268 DOI: 10.1038/onc.2012.135  1
2013 Acosta MT, Bearden CE, Castellanos XF, Cutting L, Elgersma Y, Gioia G, Gutmann DH, Lee YS, Legius E, Muenke M, North K, Parada LF, Ratner N, Hunter-Schaedle K, Silva AJ. Corrigendum to "The Learning Disabilities Network (LeaDNet): Using Neurofibromatosis Type 1 [NF1] as a Paradigm for Translational Research" American Journal of Medical Genetics, Part A. 161: 236. DOI: 10.1002/ajmg.a.35667  1
2012 Keng VW, Watson AL, Rahrmann EP, Li H, Tschida BR, Moriarity BS, Choi K, Rizvi TA, Collins MH, Wallace MR, Ratner N, Largaespada DA. Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST. Sarcoma. 2012: 620834. PMID 23319880 DOI: 10.1155/2012/620834  1
2012 Guo L, Moon C, Niehaus K, Zheng Y, Ratner N. Rac1 controls Schwann cell myelination through cAMP and NF2/merlin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 17251-61. PMID 23197717 DOI: 10.1523/JNEUROSCI.2461-12.2012  1
2012 Gutmann DH, Parada LF, Silva AJ, Ratner N. Neurofibromatosis type 1: modeling CNS dysfunction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 14087-93. PMID 23055477 DOI: 10.1523/JNEUROSCI.3242-12.2012  1
2012 Patmore DM, Welch S, Fulkerson PC, Wu J, Choi K, Eaves D, Kordich JJ, Collins MH, Cripe TP, Ratner N. In vivo regulation of TGF-β by R-Ras2 revealed through loss of the RasGAP protein NF1. Cancer Research. 72: 5317-27. PMID 22918885 DOI: 10.1158/0008-5472.CAN-12-1972  1
2012 Acosta MT, Bearden CE, Castellanos FX, Castellanos XF, Cutting L, Elgersma Y, Gioia G, Gutmann DH, Lee YS, Legius E, Muenke M, North K, Parada LF, Ratner N, Hunter-Schaedle K, et al. The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research. American Journal of Medical Genetics. Part A. 158: 2225-32. PMID 22821737 DOI: 10.1002/ajmg.a.35535  1
2012 Patel AV, Eaves D, Jessen WJ, Rizvi TA, Ecsedy JA, Qian MG, Aronow BJ, Perentesis JP, Serra E, Cripe TP, Miller SJ, Ratner N. Ras-driven transcriptome analysis identifies aurora kinase A as a potential malignant peripheral nerve sheath tumor therapeutic target. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 5020-30. PMID 22811580 DOI: 10.1158/1078-0432.CCR-12-1072  1
2012 Keng VW, Rahrmann EP, Watson AL, Tschida BR, Moertel CL, Jessen WJ, Rizvi TA, Collins MH, Ratner N, Largaespada DA. PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors. Cancer Research. 72: 3405-13. PMID 22700876 DOI: 10.1158/0008-5472.CAN-11-4092  1
2012 Kalamarides M, Acosta MT, Babovic-Vuksanovic D, Carpen O, Cichowski K, Evans DG, Giancotti F, Hanemann CO, Ingram D, Lloyd AC, Mayes DA, Messiaen L, Morrison H, North K, Packer R, ... ... Ratner N, et al. Neurofibromatosis 2011: a report of the Children's Tumor Foundation annual meeting. Acta Neuropathologica. 123: 369-80. PMID 22083253 DOI: 10.1007/s00401-011-0905-0  1
2012 Wu J, Dombi E, Jousma E, Scott Dunn R, Lindquist D, Schnell BM, Kim MO, Kim A, Widemann BC, Cripe TP, Ratner N. Preclincial testing of sorafenib and RAD001 in the Nf(flox/flox) ;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging. Pediatric Blood & Cancer. 58: 173-80. PMID 21319287 DOI: 10.1002/pbc.23015  1
2012 Meany H, Widemann BC, Ratner N. Malignant peripheral nerve sheath tumors: Prognostic and diagnostic markers and therapeutic targets Neurofibromatosis Type 1: Molecular and Cellular Biology. 2147483647: 445-467. DOI: 10.1007/978-3-642-32864-0_29  1
2011 Yang J, Ylipää A, Sun Y, Zheng H, Chen K, Nykter M, Trent J, Ratner N, Lev DC, Zhang W. Genomic and molecular characterization of malignant peripheral nerve sheath tumor identifies the IGF1R pathway as a primary target for treatment. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 7563-73. PMID 22042973 DOI: 10.1158/1078-0432.CCR-11-1707  1
2011 Wood M, Rawe M, Johansson G, Pang S, Soderquist RS, Patel AV, Nelson S, Seibel W, Ratner N, Sanchez Y. Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells. Molecular Cancer Therapeutics. 10: 1740-50. PMID 21697395 DOI: 10.1158/1535-7163.MCT-11-0309  1
2011 Shang X, Cancelas JA, Li L, Guo F, Liu W, Johnson JF, Ficker A, Daria D, Geiger H, Ratner N, Zheng Y. R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. The Journal of Biological Chemistry. 286: 24068-78. PMID 21572048 DOI: 10.1074/jbc.M111.226951  1
2011 Mayes DA, Rizvi TA, Cancelas JA, Kolasinski NT, Ciraolo GM, Stemmer-Rachamimov AO, Ratner N. Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation. Cancer Research. 71: 4675-85. PMID 21551249 DOI: 10.1158/0008-5472.CAN-10-4558  1
2010 Ryan MA, Nattamai KJ, Xing E, Schleimer D, Daria D, Sengupta A, Köhler A, Liu W, Gunzer M, Jansen M, Ratner N, Le Cras TD, Waterstrat A, Van Zant G, Cancelas JA, et al. Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nature Medicine. 16: 1141-6. PMID 20871610 DOI: 10.1038/nm.2217  1
2010 Hummel TR, Jessen WJ, Miller SJ, Kluwe L, Mautner VF, Wallace MR, Lázaro C, Page GP, Worley PF, Aronow BJ, Schorry EK, Ratner N. Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 5048-57. PMID 20739432 DOI: 10.1158/1078-0432.CCR-10-0613  1
2010 Bosco EE, Nakai Y, Hennigan RF, Ratner N, Zheng Y. NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation. Oncogene. 29: 2540-9. PMID 20154721 DOI: 10.1038/onc.2010.20  1
2010 Kissil JL, Blakeley JO, Ferner RE, Huson SM, Kalamarides M, Mautner VF, McCormick F, Morrison H, Packer R, Ramesh V, Ratner N, Rauen KA, Stevenson DA, Hunter-Schaedle K, North K. What's new in neurofibromatosis? Proceedings from the 2009 NF Conference: new frontiers. American Journal of Medical Genetics. Part A. 152: 269-83. PMID 20082461 DOI: 10.1002/ajmg.a.33189  1
2010 Miller SJ, Lan ZD, Hardiman A, Wu J, Kordich JJ, Patmore DM, Hegde RS, Cripe TP, Cancelas JA, Collins MH, Ratner N. Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis. Oncogene. 29: 368-79. PMID 19901965 DOI: 10.1038/onc.2009.360  1
2009 Miller SJ, Jessen WJ, Mehta T, Hardiman A, Sites E, Kaiser S, Jegga AG, Li H, Upadhyaya M, Giovannini M, Muir D, Wallace MR, Lopez E, Serra E, Nielsen GP, ... ... Ratner N, et al. Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene. Embo Molecular Medicine. 1: 236-48. PMID 20049725 DOI: 10.1002/emmm.200900027  1
2009 Mahller YY, Williams JP, Baird WH, Mitton B, Grossheim J, Saeki Y, Cancelas JA, Ratner N, Cripe TP. Neuroblastoma cell lines contain pluripotent tumor initiating cells that are susceptible to a targeted oncolytic virus. Plos One. 4: e4235. PMID 19156211 DOI: 10.1371/journal.pone.0004235  1
2008 Williams JP, Wu J, Johansson G, Rizvi TA, Miller SC, Geiger H, Malik P, Li W, Mukouyama YS, Cancelas JA, Ratner N. Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. Cell Stem Cell. 3: 658-69. PMID 19041782 DOI: 10.1016/j.stem.2008.10.003  1
2008 Carroll SL, Ratner N. How does the Schwann cell lineage form tumors in NF1? Glia. 56: 1590-605. PMID 18803326 DOI: 10.1002/glia.20776  1
2008 Johansson G, Mahller YY, Collins MH, Kim MO, Nobukuni T, Perentesis J, Cripe TP, Lane HA, Kozma SC, Thomas G, Ratner N. Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors. Molecular Cancer Therapeutics. 7: 1237-45. PMID 18483311 DOI: 10.1158/1535-7163.MCT-07-2335  1
2008 Wu J, Williams JP, Rizvi TA, Kordich JJ, Witte D, Meijer D, Stemmer-Rachamimov AO, Cancelas JA, Ratner N. Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells. Cancer Cell. 13: 105-16. PMID 18242511 DOI: 10.1016/j.ccr.2007.12.027  1
2007 Monk KR, Wu J, Williams JP, Finney BA, Fitzgerald ME, Filippi MD, Ratner N. Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve. Neuron Glia Biology. 3: 233-44. PMID 18634614 DOI: 10.1017/S1740925X08000021  1
2007 Mahller YY, Vaikunth SS, Currier MA, Miller SJ, Ripberger MC, Hsu YH, Mehrian-Shai R, Collins MH, Crombleholme TM, Ratner N, Cripe TP. Oncolytic HSV and erlotinib inhibit tumor growth and angiogenesis in a novel malignant peripheral nerve sheath tumor xenograft model. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 279-86. PMID 17235305 DOI: 10.1038/sj.mt.6300038  1
2006 Ratner N, Williams JP, Kordich JJ, Kim HA. Schwann cell preparation from single mouse embryos: analyses of neurofibromin function in Schwann cells. Methods in Enzymology. 407: 22-33. PMID 16757311 DOI: 10.1016/S0076-6879(05)07003-5  1
2006 Wu J, Crimmins JT, Monk KR, Williams JP, Fitzgerald ME, Tedesco S, Ratner N. Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma. The American Journal of Pathology. 168: 1686-96. PMID 16651634 DOI: 10.2353/ajpath.2006.050859  1
2006 Nakai Y, Zheng Y, MacCollin M, Ratner N. Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3390-5. PMID 16571745 DOI: 10.1523/JNEUROSCI.4865-05.2006  1
2006 Miller SJ, Rangwala F, Williams J, Ackerman P, Kong S, Jegga AG, Kaiser S, Aronow BJ, Frahm S, Kluwe L, Mautner V, Upadhyaya M, Muir D, Wallace M, Hagen J, ... ... Ratner N, et al. Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer Research. 66: 2584-91. PMID 16510576 DOI: 10.1158/0008-5472.CAN-05-3330  1
2006 Mahller YY, Rangwala F, Ratner N, Cripe TP. Malignant peripheral nerve sheath tumors with high and low Ras-GTP are permissive for oncolytic herpes simplex virus mutants. Pediatric Blood & Cancer. 46: 745-54. PMID 16124003 DOI: 10.1002/pbc.20565  1
2006 Ratner N, Miller SJ. Model systems for neurofibroma and malignant peripheral nerve sheath tumor Drug Discovery Today: Disease Models. 3: 175-182. DOI: 10.1016/j.ddmod.2006.06.001  1
2005 Aguirre A, Rizvi TA, Ratner N, Gallo V. Overexpression of the epidermal growth factor receptor confers migratory properties to nonmigratory postnatal neural progenitors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11092-106. PMID 16319309 DOI: 10.1523/JNEUROSCI.2981-05.2005  1
2005 Ling BC, Wu J, Miller SJ, Monk KR, Shamekh R, Rizvi TA, Decourten-Myers G, Vogel KS, DeClue JE, Ratner N. Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis. Cancer Cell. 7: 65-75. PMID 15652750 DOI: 10.1016/j.ccr.2004.10.016  1
2004 Tang Y, Lu A, Ran R, Aronow BJ, Schorry EK, Hopkin RJ, Gilbert DL, Glauser TA, Hershey AD, Richtand NW, Privitera M, Dalvi A, Sahay A, Szaflarski JP, Ficker DM, ... Ratner N, et al. Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1. Brain Research. Molecular Brain Research. 132: 155-67. PMID 15582155 DOI: 10.1016/j.molbrainres.2003.10.014  1
2004 Corfas G, Velardez MO, Ko CP, Ratner N, Peles E. Mechanisms and roles of axon-Schwann cell interactions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 9250-60. PMID 15496660 DOI: 10.1523/JNEUROSCI.3649-04.2004  1
2004 Stemmer-Rachamimov AO, Louis DN, Nielsen GP, Antonescu CR, Borowsky AD, Bronson RT, Burns DK, Cervera P, McLaughlin ME, Reifenberger G, Schmale MC, MacCollin M, Chao RC, Cichowski K, Kalamarides M, ... ... Ratner N, et al. Comparative pathology of nerve sheath tumors in mouse models and humans. Cancer Research. 64: 3718-24. PMID 15150133 DOI: 10.1158/0008-5472.CAN-03-4079  1
2004 Stickney JT, Bacon WC, Rojas M, Ratner N, Ip W. Activation of the tumor suppressor merlin modulates its interaction with lipid rafts. Cancer Research. 64: 2717-24. PMID 15087385 DOI: 10.1158/0008-5472.CAN-03-3798  1
2004 Huang Y, Rangwala F, Fulkerson PC, Ling B, Reed E, Cox AD, Kamholz J, Ratner N. Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells. Oncogene. 23: 368-78. PMID 14724565 DOI: 10.1038/sj.onc.1207075  1
2003 Yang FC, Ingram DA, Chen S, Hingtgen CM, Ratner N, Monk KR, Clegg T, White H, Mead L, Wenning MJ, Williams DA, Kapur R, Atkinson SJ, Clapp DW. Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells. The Journal of Clinical Investigation. 112: 1851-61. PMID 14679180 DOI: 10.1172/JCI19195  1
2003 Bennett MR, Rizvi TA, Karyala S, McKinnon RD, Ratner N. Aberrant growth and differentiation of oligodendrocyte progenitors in neurofibromatosis type 1 mutants. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7207-17. PMID 12904481  1
2003 Miller SJ, Li H, Rizvi TA, Huang Y, Johansson G, Bowersock J, Sidani A, Vitullo J, Vogel K, Parysek LM, DeClue JE, Ratner N. Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis. Molecular and Cellular Biology. 23: 2213-24. PMID 12612091 DOI: 10.1128/MCB.23.6.2213-2224.2003  1
2003 Manent J, Oguievetskaia K, Bayer J, Ratner N, Giovannini M. Magnetic cell sorting for enriching Schwann cells from adult mouse peripheral nerves. Journal of Neuroscience Methods. 123: 167-73. PMID 12606065 DOI: 10.1016/S0165-0270(02)00349-7  1
2002 Rizvi TA, Huang Y, Sidani A, Atit R, Largaespada DA, Boissy RE, Ratner N. A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9831-40. PMID 12427839  1
2002 Xu Y, Chiamvimonvat N, Vázquez AE, Akunuru S, Ratner N, Yamoah EN. Gene-targeted deletion of neurofibromin enhances the expression of a transient outward K+ current in Schwann cells: a protein kinase A-mediated mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9194-202. PMID 12417644  1
2002 Morfini G, Szebenyi G, Elluru R, Ratner N, Brady ST. Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility. The Embo Journal. 21: 281-93. PMID 11823421 DOI: 10.1093/emboj/21.3.281  1
2002 Bashour AM, Meng JJ, Ip W, MacCollin M, Ratner N. The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells. Molecular and Cellular Biology. 22: 1150-7. PMID 11809806 DOI: 10.1128/MCB.22.4.1150-1157.2002  1
2001 Shaw RJ, Paez JG, Curto M, Yaktine A, Pruitt WM, Saotome I, O'Bryan JP, Gupta V, Ratner N, Der CJ, Jacks T, McClatchey AI. The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Developmental Cell. 1: 63-72. PMID 11703924 DOI: 10.1016/S1534-5807(01)00009-0  1
2001 Sherman LS, Ratner N. Immunocytochemical assay for Ras activity. Methods in Enzymology. 333: 348-55. PMID 11400351 DOI: 10.1016/S0076-6879(01)33069-0  1
2001 Steigerwald K, Santoro IM, Kordich JJ, Gismondi V, Trzepacz C, Badiali M, Giangaspero F, Balko MG, Graham JS, Ratner N, Lowy AM, Varesco L, Groden J. A distinct splice form of APC is highly expressed in neurones but not commonly mutated in neuroepithelial tumours. Journal of Medical Genetics. 38: 257-62. PMID 11370631  1
2001 Mashour GA, Ratner N, Khan GA, Wang HL, Martuza RL, Kurtz A. The angiogenic factor midkine is aberrantly expressed in NF1-deficient Schwann cells and is a mitogen for neurofibroma-derived cells. Oncogene. 20: 97-105. PMID 11244508 DOI: 10.1038/sj.onc.1204026  1
2001 Kim HA, Ratner N, Roberts TM, Stiles CD. Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1110-6. PMID 11160381  1
2000 Meng JJ, Lowrie DJ, Sun H, Dorsey E, Pelton PD, Bashour AM, Groden J, Ratner N, Ip W. Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlin. Journal of Neuroscience Research. 62: 491-502. PMID 11070492 DOI: 10.1002/1097-4547(20001115)62:4<491::AID-JNR3>3.0.CO;2-D  1
2000 Lim DJ, Rubenstein AE, Evans DG, Jacks T, Seizinger BG, Baser ME, Beebe D, Brackmann DE, Chiocca EA, Fehon RG, Giovannini M, Glazer R, Gusella JF, Gutmann DH, Korf B, ... ... Ratner N, et al. Advances in neurofibromatosis 2 (NF2): a workshop report. Journal of Neurogenetics. 14: 63-106. PMID 10992163  1
2000 Sherman LS, Rizvi TA, Karyala S, Ratner N. CD44 enhances neuregulin signaling by Schwann cells. The Journal of Cell Biology. 150: 1071-84. PMID 10973996 DOI: 10.1083/jcb.150.5.1071  1
2000 Sherman LS, Atit R, Rosenbaum T, Cox AD, Ratner N. Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts. The Journal of Biological Chemistry. 275: 30740-5. PMID 10900196 DOI: 10.1074/jbc.M001702200  1
2000 Atit RP, Mitchell K, Nguyen L, Warshawsky D, Ratner N. The neurofibromatosis type 1 (Nf1) tumor suppressor is a modifier of carcinogen-induced pigmentation and papilloma formation in C57BL/6 mice. The Journal of Investigative Dermatology. 114: 1093-100. PMID 10844550 DOI: 10.1046/j.1523-1747.2000.00994.x  1
2000 DeClue JE, Heffelfinger S, Benvenuto G, Ling B, Li S, Rui W, Vass WC, Viskochil D, Ratner N. Epidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal models. The Journal of Clinical Investigation. 105: 1233-41. PMID 10791998 DOI: 10.1172/JCI7610  1
1999 Sherman L, Sleeman JP, Hennigan RF, Herrlich P, Ratner N. Overexpression of activated neu/erbB2 initiates immortalization and malignant transformation of immature Schwann cells in vitro. Oncogene. 18: 6692-9. PMID 10597275 DOI: 10.1038/sj.onc.1203055  1
1999 Rosenbaum T, Kim HA, Boissy YL, Ling B, Ratner N. Neurofibromin, the neurofibromatosis type 1 Ras-GAP, is required for appropriate P0 expression and myelination. Annals of the New York Academy of Sciences. 883: 203-14. PMID 10586246  1
1999 Atit RP, Crowe MJ, Greenhalgh DG, Wenstrup RJ, Ratner N. The Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblasts. The Journal of Investigative Dermatology. 112: 835-42. PMID 10383727 DOI: 10.1046/j.1523-1747.1999.00609.x  1
1999 Rizvi TA, Akunuru S, de Courten-Myers G, Switzer RC, Nordlund ML, Ratner N. Region-specific astrogliosis in brains of mice heterozygous for mutations in the neurofibromatosis type 1 (Nf1) tumor suppressor. Brain Research. 816: 111-23. PMID 9878702 DOI: 10.1016/S0006-8993(98)01133-0  1
1998 Pelton PD, Sherman LS, Rizvi TA, Marchionni MA, Wood P, Friedman RA, Ratner N. Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells. Oncogene. 17: 2195-209. PMID 9811451 DOI: 10.1038/sj.onc.1202141  1
1998 Ratner N, Bloom GS, Brady ST. A role for cyclin-dependent kinase(s) in the modulation of fast anterograde axonal transport: effects defined by olomoucine and the APC tumor suppressor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 7717-26. PMID 9742142  1
1997 Rosenbaum C, Karyala S, Marchionni MA, Kim HA, Krasnoselsky AL, Happel B, Isaacs I, Brackenbury R, Ratner N. Schwann cells express NDF and SMDF/n-ARIA mRNAs, secrete neuregulin, and show constitutive activation of erbB3 receptors: evidence for a neuregulin autocrine loop. Experimental Neurology. 148: 604-15. PMID 9417836 DOI: 10.1006/exnr.1997.6696  1
1997 Kim HA, DeClue JE, Ratner N. cAMP-dependent protein kinase A is required for Schwann cell growth: interactions between the cAMP and neuregulin/tyrosine kinase pathways. Journal of Neuroscience Research. 49: 236-47. PMID 9272646 DOI: 10.1002/(SICI)1097-4547(19970715)49:2<236::AID-JNR12>3.0.CO;2-Z  1
1997 North KN, Riccardi V, Samango-Sprouse C, Ferner R, Moore B, Legius E, Ratner N, Denckla MB. Cognitive function and academic performance in neurofibromatosis. 1: consensus statement from the NF1 Cognitive Disorders Task Force. Neurology. 48: 1121-7. PMID 9109916  1
1997 Kim HA, Ling B, Ratner N. Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase. Molecular and Cellular Biology. 17: 862-72. PMID 9001241  1
1997 Rosenbaum T, Patrie KM, Ratner N. Neurofibromatosis type 1: Genetic and cellular mechanisms of peripheral nerve tumor formation Neuroscientist. 3: 712-720.  1
1995 Wrabetz L, Feltri ML, Kim H, Daston M, Kamholz J, Scherer SS, Ratner N. Regulation of neurofibromin expression in rat sciatic nerve and cultured Schwann cells. Glia. 15: 22-32. PMID 8847098 DOI: 10.1002/glia.440150104  1
1995 Rosenbaum T, Boissy YL, Kombrinck K, Brannan CI, Jenkins NA, Copeland NG, Ratner N. Neurofibromin-deficient fibroblasts fail to form perineurium in vitro. Development (Cambridge, England). 121: 3583-92. PMID 8582272  1
1995 Zhang SM, Marsh R, Ratner N, Brackenbury R. Myelin glycoprotein P0 is expressed at early stages of chicken and rat embryogenesis. Journal of Neuroscience Research. 40: 241-50. PMID 7745617 DOI: 10.1002/jnr.490400213  1
1995 Kim HA, Rosenbaum T, Marchionni MA, Ratner N, DeClue JE. Schwann cells from neurofibromin deficient mice exhibit activation of p21ras, inhibition of cell proliferation and morphological changes. Oncogene. 11: 325-35. PMID 7624147  1
1995 Guénard V, Rosenbaum T, Gwynn LA, Doetschman T, Ratner N, Wood PM. Effect of transforming growth factor-beta 1 and -beta 2 on Schwann cell proliferation on neurites. Glia. 13: 309-18. PMID 7615339 DOI: 10.1002/glia.440130407  1
1995 Nordlund ML, Rizvi TA, Brannan CI, Ratner N. Neurofibromin expression and astrogliosis in neurofibromatosis (type 1) brains. Journal of Neuropathology and Experimental Neurology. 54: 588-600. PMID 7602332  1
1994 Malhotra R, Ratner N. Localization of neurofibromin to keratinocytes and melanocytes in developing rat and human skin. The Journal of Investigative Dermatology. 102: 812-8. PMID 8176268  1
1994 Daston MM, Ratner N. Amphoterin (P30, HMG-1) and RIP are early markers of oligodendrocytes in the developing rat spinal cord. Journal of Neurocytology. 23: 323-32. PMID 8089705 DOI: 10.1007/BF01188500  1
1994 Bhattacharyya A, Brackenbury R, Ratner N. Axons arrest the migration of Schwann cell precursors. Development (Cambridge, England). 120: 1411-20. PMID 8050352  1
1994 Krasnoselsky A, Massay MJ, DeFrances MC, Michalopoulos G, Zarnegar R, Ratner N. Hepatocyte growth factor is a mitogen for Schwann cells and is present in neurofibromas. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 7284-90. PMID 7996175  1
1994 Brannan CI, Perkins AS, Vogel KS, Ratner N, Nordlund ML, Reid SW, Buchberg AM, Jenkins NA, Parada LF, Copeland NG. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes & Development. 8: 1019-29. PMID 7926784  1
1993 Nordlund M, Gu X, Shipley MT, Ratner N. Neurofibromin is enriched in the endoplasmic reticulum of CNS neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 1588-600. PMID 8463837  1
1993 Bhattacharyya A, Brackenbury R, Ratner N. Neuron-Schwann cell signals are conserved across species: purification and characterization of embryonic chicken Schwann cells. Journal of Neuroscience Research. 35: 1-13. PMID 7685394 DOI: 10.1002/jnr.490350102  1
1992 Bhattacharyya A, Oppenheim RW, Prevette D, Moore BW, Brackenbury R, Ratner N. S100 is present in developing chicken neurons and Schwann cells and promotes motor neuron survival in vivo. Journal of Neurobiology. 23: 451-66. PMID 1634890 DOI: 10.1002/neu.480230410  1
1992 DeClue JE, Papageorge AG, Fletcher JA, Diehl SR, Ratner N, Vass WC, Lowy DR. Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis. Cell. 69: 265-73. PMID 1568246 DOI: 10.1016/0092-8674(92)90407-4  1
1992 Daston MM, Scrable H, Nordlund M, Sturbaum AK, Nissen LM, Ratner N. The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes. Neuron. 8: 415-28. PMID 1550670 DOI: 10.1016/0896-6273(92)90270-N  1
1992 Nordlund M, Hong D, Fei X, Ratner N. Schwann cells and cells in the oligodendrocyte lineage proliferate in response to a 50,000 dalton membrane-associated mitogen present in developing brain. Glia. 5: 182-92. PMID 1534065 DOI: 10.1002/glia.440050304  1
1992 Daston MM, Ratner N. Neurofibromin, a predominantly neuronal GTPase activating protein in the adult, is ubiquitously expressed during development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 195: 216-26. PMID 1301085 DOI: 10.1002/aja.1001950307  1
1992 Norgren RB, Ratner N, Brackenbury R. Development of olfactory nerve glia defined by a monoclonal antibody specific for Schwann cells. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 194: 231-8. PMID 1281697 DOI: 10.1002/aja.1001940308  1
1991 Bhattacharyya A, Frank E, Ratner N, Brackenbury R. P0 is an early marker of the Schwann cell lineage in chickens. Neuron. 7: 831-44. PMID 1720625 DOI: 10.1016/0896-6273(91)90285-8  1
1988 Ratner N, Hong DM, Lieberman MA, Bunge RP, Glaser L. The neuronal cell-surface molecule mitogenic for Schwann cells is a heparin-binding protein. Proceedings of the National Academy of Sciences of the United States of America. 85: 6992-6. PMID 3413130  1
1986 Ratner N, Elbein A, Bunge MB, Porter S, Bunge RP, Glaser L. Specific asparagine-linked oligosaccharides are not required for certain neuron-neuron and neuron-Schwann cell interactions. The Journal of Cell Biology. 103: 159-70. PMID 3522602  1
1986 Ratner N, Bunge RP, Glaser L. Schwann cell proliferation in vitro. An overview. Annals of the New York Academy of Sciences. 486: 170-81. PMID 3471154  1
1985 Ratner N, Bunge RP, Glaser L. A neuronal cell surface heparan sulfate proteoglycan is required for dorsal root ganglion neuron stimulation of Schwann cell proliferation. The Journal of Cell Biology. 101: 744-54. PMID 3161898  1
1984 Ratner N, Glaser L, Bunge RP. PC12 cells as a source of neurite-derived cell surface mitogen, which stimulates Schwann cell division. The Journal of Cell Biology. 98: 1150-5. PMID 6321518  1
1983 Ratner N, Mahler HR. Structural organization of filamentous proteins in postsynaptic density. Biochemistry. 22: 2446-53. PMID 6860641  1
1983 Ratner N, Mahler H. Isolation of postsynaptic densities retaining their membrane attachment. Neuroscience. 9: 631-44. PMID 6413886 DOI: 10.1016/0306-4522(83)90179-3  1
1982 Mahler HR, Kleine LP, Ratner N, Sorensen RG. Identification and topography of synaptic phosphoproteins. Progress in Brain Research. 56: 27-48. PMID 7163503 DOI: 10.1016/S0079-6123(08)63767-X  1
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