David Bredt - Publications

Affiliations: 
Eli Lilly and Co., Basingstoke, England, United Kingdom 
Area:
Neurotransmitters

219 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Knopp KL, Simmons RMA, Guo W, Adams BL, Gardinier KM, Gernert DL, Ornstein PL, Porter W, Reel J, Ding C, Wang H, Qian Y, Burris KD, Need A, Barth V, ... ... Bredt DS, et al. Modulation of TARP γ8-containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain. The Journal of Pharmacology and Experimental Therapeutics. PMID 30910921 DOI: 10.1124/jpet.118.250126  0.6
2016 Kato AS, Burris KD, Gardinier KM, Gernert DL, Porter WJ, Reel J, Ding C, Tu Y, Schober DA, Lee MR, Heinz BA, Fitch TE, Gleason SD, Catlow JT, Yu H, ... ... Bredt DS, et al. Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism. Nature Medicine. PMID 27820603 DOI: 10.1038/nm.4221  0.68
2016 Gardinier KM, Gernert DL, Porter WJ, Reel JK, Ornstein PL, Spinazze P, Stevens FC, Hahn P, Hollinshead SP, Mayhugh D, Schkeryantz J, Khilevich A, De Frutos O, Gleason SD, Kato AS, ... ... Bredt D, et al. The Discovery of The First α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent Upon Transmembrane AMPA Receptor Regulatory Protein (TARP) Gamma-8. Journal of Medicinal Chemistry. PMID 27067148 DOI: 10.1021/acs.jmedchem.6b00125  1
2016 Gu S, Matta JA, Lord B, Harrington AW, Sutton SW, Davini WB, Bredt DS. Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO. Neuron. PMID 26875622 DOI: 10.1016/j.neuron.2016.01.018  1
2016 Erlenhardt N, Yu H, Abiraman K, Yamasaki T, Wadiche JI, Tomita S, Bredt DS. Porcupine Controls Hippocampal AMPAR Levels, Composition, and Synaptic Transmission. Cell Reports. PMID 26776514 DOI: 10.1016/j.celrep.2015.12.078  1
2015 Bredt DS, Furey ML, Chen G, Lovenberg T, Drevets WC, Manji HK. Translating depression biomarkers for improved targeted therapies. Neuroscience and Biobehavioral Reviews. PMID 26432926 DOI: 10.1016/j.neubiorev.2015.09.013  1
2013 Yudowski GA, Olsen O, Adesnik H, Marek KW, Bredt DS. Acute inactivation of PSD-95 destabilizes AMPA receptors at hippocampal synapses. Plos One. 8: e53965. PMID 23342049 DOI: 10.1371/journal.pone.0053965  1
2012 Kato AS, Knierman MD, Siuda ER, Isaac JT, Nisenbaum ES, Bredt DS. Glutamate receptor δ2 associates with metabotropic glutamate receptor 1 (mGluR1), protein kinase Cγ, and canonical transient receptor potential 3 and regulates mGluR1-mediated synaptic transmission in cerebellar Purkinje neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15296-308. PMID 23115168 DOI: 10.1523/JNEUROSCI.0705-12.2012  1
2012 Gill MB, Kato AS, Wang H, Bredt DS. AMPA receptor modulation by cornichon-2 dictated by transmembrane AMPA receptor regulatory protein isoform. The European Journal of Neuroscience. 35: 182-94. PMID 22211840 DOI: 10.1111/j.1460-9568.2011.07948.x  1
2011 Sumioka A, Brown TE, Kato AS, Bredt DS, Kauer JA, Tomita S. PDZ binding of TARPγ-8 controls synaptic transmission but not synaptic plasticity. Nature Neuroscience. 14: 1410-2. PMID 22002768 DOI: 10.1038/nn.2952  1
2011 Gill MB, Kato AS, Roberts MF, Yu H, Wang H, Tomita S, Bredt DS. Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6928-38. PMID 21543622 DOI: 10.1523/JNEUROSCI.6271-10.2011  1
2011 Ivanova S, Gregorc U, Vidergar N, Javier R, Bredt DS, Vandenabeele P, Pardo J, Simon MM, Turk V, Banks L, Turk B. MAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis. Cell Death & Disease. 2: e116. PMID 21368887 DOI: 10.1038/cddis.2010.92  1
2011 Schober DA, Gill MB, Yu H, Gernert DL, Jeffries MW, Ornstein PL, Kato AS, Felder CC, Bredt DS. Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators. The Journal of Biological Chemistry. 286: 13134-42. PMID 21343286 DOI: 10.1074/jbc.M110.212522  1
2011 Gill MB, Bredt DS. An emerging role for TARPs in neuropsychiatric disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 362-3. PMID 21116256 DOI: 10.1038/npp.2010.149  1
2010 Kato AS, Gill MB, Ho MT, Yu H, Tu Y, Siuda ER, Wang H, Qian YW, Nisenbaum ES, Tomita S, Bredt DS. Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron. 68: 1082-96. PMID 21172611 DOI: 10.1016/j.neuron.2010.11.026  1
2010 Kato AS, Gill MB, Yu H, Nisenbaum ES, Bredt DS. TARPs differentially decorate AMPA receptors to specify neuropharmacology. Trends in Neurosciences. 33: 241-8. PMID 20219255 DOI: 10.1016/j.tins.2010.02.004  1
2009 Noritake J, Fukata Y, Iwanaga T, Hosomi N, Tsutsumi R, Matsuda N, Tani H, Iwanari H, Mochizuki Y, Kodama T, Matsuura Y, Bredt DS, Hamakubo T, Fukata M. Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95. The Journal of Cell Biology. 186: 147-60. PMID 19596852 DOI: 10.1083/jcb.200903101  1
2008 Horresh I, Poliak S, Grant S, Bredt D, Rasband MN, Peles E. Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 14213-22. PMID 19109503 DOI: 10.1523/JNEUROSCI.3398-08.2008  1
2008 Kato AS, Siuda ER, Nisenbaum ES, Bredt DS. AMPA receptor subunit-specific regulation by a distinct family of type II TARPs. Neuron. 59: 986-96. PMID 18817736 DOI: 10.1016/j.neuron.2008.07.034  1
2008 Ponimaskin E, Dityateva G, Ruonala MO, Fukata M, Fukata Y, Kobe F, Wouters FS, Delling M, Bredt DS, Schachner M, Dityatev A. Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 8897-907. PMID 18768683 DOI: 10.1523/JNEUROSCI.2171-08.2008  1
2008 Menuz K, O'Brien JL, Karmizadegan S, Bredt DS, Nicoll RA. TARP redundancy is critical for maintaining AMPA receptor function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 8740-6. PMID 18753375 DOI: 10.1523/JNEUROSCI.1319-08.2008  1
2008 Ogawa Y, Horresh I, Trimmer JS, Bredt DS, Peles E, Rasband MN. Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 5731-9. PMID 18509034 DOI: 10.1523/JNEUROSCI.4431-07.2008  1
2008 Srinivasan K, Roosa J, Olsen O, Lee SH, Bredt DS, McConnell SK. MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex. Development (Cambridge, England). 135: 1781-90. PMID 18403412 DOI: 10.1242/dev.013847  1
2008 Chen YQ, Kuo MS, Li S, Bui HH, Peake DA, Sanders PE, Thibodeaux SJ, Chu S, Qian YW, Zhao Y, Bredt DS, Moller DE, Konrad RJ, Beigneux AP, Young SG, et al. AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. The Journal of Biological Chemistry. 283: 10048-57. PMID 18238778 DOI: 10.1074/jbc.M708151200  1
2008 Zhao Y, Chen YQ, Bonacci TM, Bredt DS, Li S, Bensch WR, Moller DE, Kowala M, Konrad RJ, Cao G. Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. The Journal of Biological Chemistry. 283: 8258-65. PMID 18195019 DOI: 10.1074/jbc.M710422200  1
2007 Tomita S, Byrd RK, Rouach N, Bellone C, Venegas A, O'Brien JL, Kim KS, Olsen O, Nicoll RA, Bredt DS. AMPA receptors and stargazin-like transmembrane AMPA receptor-regulatory proteins mediate hippocampal kainate neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 104: 18784-8. PMID 18000041 DOI: 10.1073/pnas.0708970104  1
2007 Olsen O, Funke L, Long JF, Fukata M, Kazuta T, Trinidad JC, Moore KA, Misawa H, Welling PA, Burlingame AL, Zhang M, Bredt DS. Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice. The Journal of Cell Biology. 179: 151-64. PMID 17923534 DOI: 10.1083/jcb.200702054  1
2007 Milstein AD, Zhou W, Karimzadegan S, Bredt DS, Nicoll RA. TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating. Neuron. 55: 905-18. PMID 17880894 DOI: 10.1016/j.neuron.2007.08.022  1
2007 Kato AS, Bredt DS. Pharmacological regulation of ion channels by auxiliary subunits. Current Opinion in Drug Discovery & Development. 10: 565-72. PMID 17786855  1
2007 Kato AS, Zhou W, Milstein AD, Knierman MD, Siuda ER, Dotzlaf JE, Yu H, Hale JE, Nisenbaum ES, Nicoll RA, Bredt DS. New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 4969-77. PMID 17475805 DOI: 10.1523/JNEUROSCI.5561-06.2007  1
2007 Reese ML, Dakoji S, Bredt DS, Dötsch V. The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a. Nature Structural & Molecular Biology. 14: 155-63. PMID 17220895 DOI: 10.1038/nsmb1195  1
2007 Tomita S, Shenoy A, Fukata Y, Nicoll RA, Bredt DS. Stargazin interacts functionally with the AMPA receptor glutamate-binding module. Neuropharmacology. 52: 87-91. PMID 16919685 DOI: 10.1016/j.neuropharm.2006.07.012  1
2007 Elias GM, Funke L, Stein V, Grant SG, Bredt DS, Nicoll RA. Synapse-Specific and Developmentally Regulated Targeting of AMPA Receptors by a Family of MAGUK Scaffolding Proteins (DOI:10.1016/j.neuron.2006.09.012) Neuron. 53: 465. DOI: 10.1016/j.neuron.2007.01.007  1
2006 Elias GM, Funke L, Stein V, Grant SG, Bredt DS, Nicoll RA. Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins. Neuron. 52: 307-20. PMID 17046693 DOI: 10.1016/j.neuron.2006.09.012  1
2006 Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M. Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Science (New York, N.Y.). 313: 1792-5. PMID 16990550 DOI: 10.1126/science.1129947  1
2006 Fernández-Hernando C, Fukata M, Bernatchez PN, Fukata Y, Lin MI, Bredt DS, Sessa WC. Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. The Journal of Cell Biology. 174: 369-77. PMID 16864653 DOI: 10.1083/jcb.200601051  1
2006 Alewine C, Olsen O, Wade JB, Welling PA. TIP-1 has PDZ scaffold antagonist activity. Molecular Biology of the Cell. 17: 4200-11. PMID 16855024 DOI: 10.1091/mbc.E06-02-0129  1
2006 Tomita S, Sekiguchi M, Wada K, Nicoll RA, Bredt DS. Stargazin controls the pharmacology of AMPA receptor potentiators. Proceedings of the National Academy of Sciences of the United States of America. 103: 10064-7. PMID 16785437 DOI: 10.1073/pnas.0603128103  1
2006 Nicoll RA, Tomita S, Bredt DS. Auxiliary subunits assist AMPA-type glutamate receptors. Science (New York, N.Y.). 311: 1253-6. PMID 16513974 DOI: 10.1126/science.1123339  1
2006 Olsen O, Moore KA, Nicoll RA, Bredt DS. Synaptic transmission regulated by a presynaptic MALS/Liprin-alpha protein complex. Current Opinion in Cell Biology. 18: 223-7. PMID 16504495 DOI: 10.1016/j.ceb.2006.02.010  1
2005 Rouach N, Byrd K, Petralia RS, Elias GM, Adesnik H, Tomita S, Karimzadegan S, Kealey C, Bredt DS, Nicoll RA. TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity. Nature Neuroscience. 8: 1525-33. PMID 16222232 DOI: 10.1038/nn1551  1
2005 Olsen O, Moore KA, Fukata M, Kazuta T, Trinidad JC, Kauer FW, Streuli M, Misawa H, Burlingame AL, Nicoll RA, Bredt DS. Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. The Journal of Cell Biology. 170: 1127-34. PMID 16186258 DOI: 10.1083/jcb.200503011  1
2005 Funke L, Dakoji S, Bredt DS. Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions. Annual Review of Biochemistry. 74: 219-45. PMID 15952887 DOI: 10.1146/annurev.biochem.74.082803.133339  1
2005 Fukata Y, Tzingounis AV, Trinidad JC, Fukata M, Burlingame AL, Nicoll RA, Bredt DS. Molecular constituents of neuronal AMPA receptors. The Journal of Cell Biology. 169: 399-404. PMID 15883194 DOI: 10.1083/jcb.200501121  1
2005 Tomita S, Adesnik H, Sekiguchi M, Zhang W, Wada K, Howe JR, Nicoll RA, Bredt DS. Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature. 435: 1052-8. PMID 15858532 DOI: 10.1038/nature03624  1
2005 Kato A, Rouach N, Nicoll RA, Bredt DS. Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination. Proceedings of the National Academy of Sciences of the United States of America. 102: 5600-5. PMID 15809437 DOI: 10.1073/pnas.0501769102  1
2005 Vandenberghe W, Nicoll RA, Bredt DS. Interaction with the unfolded protein response reveals a role for stargazin in biosynthetic AMPA receptor transport. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1095-102. PMID 15689545 DOI: 10.1523/JNEUROSCI.3568-04.2005  1
2005 Campo C, Mason A, Maouyo D, Olsen O, Yoo D, Welling PA. Molecular mechanisms of membrane polarity in renal epithelial cells. Reviews of Physiology, Biochemistry and Pharmacology. 153: 47-99. PMID 15674648 DOI: 10.1007/s10254-004-0037-1  1
2005 Tomita S, Stein V, Stocker TJ, Nicoll RA, Bredt DS. Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs. Neuron. 45: 269-77. PMID 15664178 DOI: 10.1016/j.neuron.2005.01.009  1
2005 Vandenberghe W, Nicoll RA, Bredt DS. Stargazin is an AMPA receptor auxiliary subunit. Proceedings of the National Academy of Sciences of the United States of America. 102: 485-90. PMID 15630087 DOI: 10.1073/pnas.0408269102  1
2005 Olsen O, Wade JB, Morin N, Bredt DS, Welling PA. Differential localization of mammalian Lin-7 (MALS/Veli) PDZ proteins in the kidney. American Journal of Physiology. Renal Physiology. 288: F345-52. PMID 15494546 DOI: 10.1152/ajprenal.00235.2004  1
2004 Fukata M, Fukata Y, Adesnik H, Nicoll RA, Bredt DS. Identification of PSD-95 palmitoylating enzymes. Neuron. 44: 987-96. PMID 15603741 DOI: 10.1016/j.neuron.2004.12.005  1
2004 Cuadra AE, Kuo SH, Kawasaki Y, Bredt DS, Chetkovich DM. AMPA receptor synaptic targeting regulated by stargazin interactions with the Golgi-resident PDZ protein nPIST. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7491-502. PMID 15329396 DOI: 10.1523/JNEUROSCI.1255-04.2004  1
2004 Xu Y, Zhang B, Hua Z, Johns RA, Bredt DS, Tao YX. Targeted disruption of PSD-93 gene reduces platelet-activating factor-induced neurotoxicity in cultured cortical neurons. Experimental Neurology. 189: 16-24. PMID 15296832 DOI: 10.1016/j.expneurol.2004.05.013  1
2004 Vandenberghe W, Bredt DS. Early events in glutamate receptor trafficking. Current Opinion in Cell Biology. 16: 134-9. PMID 15196555 DOI: 10.1016/j.ceb.2004.01.003  1
2004 Mungrue IN, Bredt DS. nNOS at a glance: implications for brain and brawn. Journal of Cell Science. 117: 2627-9. PMID 15169833 DOI: 10.1242/jcs.01187  1
2004 McGee AW, Nunziato DA, Maltez JM, Prehoda KE, Pitt GS, Bredt DS. Calcium channel function regulated by the SH3-GK module in beta subunits. Neuron. 42: 89-99. PMID 15066267 DOI: 10.1016/S0896-6273(04)00149-7  1
2004 Kanaani J, Diacovo MJ, El-Husseini Ael-D, Bredt DS, Baekkeskov S. Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters. Journal of Cell Science. 117: 2001-13. PMID 15039456 DOI: 10.1242/jcs.01030  1
2004 Tomita S, Fukata M, Nicoll RA, Bredt DS. Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Science (New York, N.Y.). 303: 1508-11. PMID 15001777 DOI: 10.1126/science.1090262  1
2004 Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. Molecular Biology of the Cell. 15: 2205-17. PMID 14978216 DOI: 10.1091/mbc.E03-07-0493  1
2004 Parker MJ, Zhao S, Bredt DS, Sanes JR, Feng G. PSD93 regulates synaptic stability at neuronal cholinergic synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 378-88. PMID 14724236 DOI: 10.1523/JNEUROSCI.3865-03.2004  1
2004 Yoo D, Flagg TP, Olsen O, Raghuram V, Foskett JK, Welling PA. Assembly and trafficking of a multiprotein ROMK (Kir 1.1) channel complex by PDZ interactions. The Journal of Biological Chemistry. 279: 6863-73. PMID 14604981 DOI: 10.1074/jbc.M311599200  1
2003 Zhang B, Tao F, Liaw WJ, Bredt DS, Johns RA, Tao YX. Effect of knock down of spinal cord PSD-93/chapsin-110 on persistent pain induced by complete Freund's adjuvant and peripheral nerve injury. Pain. 106: 187-96. PMID 14581127 DOI: 10.1016/j.pain.2003.08.003  1
2003 Bredt DS, Nicoll RA. AMPA receptor trafficking at excitatory synapses. Neuron. 40: 361-79. PMID 14556714 DOI: 10.1016/S0896-6273(03)00640-8  1
2003 Dakoji S, Tomita S, Karimzadegan S, Nicoll RA, Bredt DS. Interaction of transmembrane AMPA receptor regulatory proteins with multiple membrane associated guanylate kinases. Neuropharmacology. 45: 849-56. PMID 14529722 DOI: 10.1016/S0028-3908(03)00267-3  1
2003 Mungrue IN, Bredt DS, Stewart DJ, Husain M. From molecules to mammals: what's NOS got to do with it? Acta Physiologica Scandinavica. 179: 123-35. PMID 14510775 DOI: 10.1046/j.1365-201X.2003.01182.x  1
2003 Chen L, El-Husseini A, Tomita S, Bredt DS, Nicoll RA. Stargazin differentially controls the trafficking of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and kainate receptors. Molecular Pharmacology. 64: 703-6. PMID 12920207 DOI: 10.1124/mol.64.3.703  1
2003 Tao YX, Rumbaugh G, Wang GD, Petralia RS, Zhao C, Kauer FW, Tao F, Zhuo M, Wenthold RJ, Raja SN, Huganir RL, Bredt DS, Johns RA. Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 6703-12. PMID 12890763  1
2003 Stein V, House DR, Bredt DS, Nicoll RA. Postsynaptic density-95 mimics and occludes hippocampal long-term potentiation and enhances long-term depression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5503-6. PMID 12843250  1
2003 Christopherson KS, Sweeney NT, Craven SE, Kang R, El-Husseini Ael-D, Bredt DS. Lipid- and protein-mediated multimerization of PSD-95: implications for receptor clustering and assembly of synaptic protein networks. Journal of Cell Science. 116: 3213-9. PMID 12829740 DOI: 10.1242/jcs.00617  1
2003 Sassoé-Pognetto M, Utvik JK, Camoletto P, Watanabe M, Stephenson FA, Bredt DS, Ottersen OP. Organization of postsynaptic density proteins and glutamate receptors in axodendritic and dendrodendritic synapses of the rat olfactory bulb. The Journal of Comparative Neurology. 463: 237-48. PMID 12820158 DOI: 10.1002/cne.10745  1
2003 Tomita S, Chen L, Kawasaki Y, Petralia RS, Wenthold RJ, Nicoll RA, Bredt DS. Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. The Journal of Cell Biology. 161: 805-16. PMID 12771129 DOI: 10.1083/jcb.200212116  1
2003 Bredt DS. Nitric oxide signaling in brain: potentiating the gain with YC-1. Molecular Pharmacology. 63: 1206-8. PMID 12761328 DOI: 10.1124/mol.63.6.1206  1
2003 McGee AW, Bredt DS. Assembly and plasticity of the glutamatergic postsynaptic specialization. Current Opinion in Neurobiology. 13: 111-8. PMID 12593989 DOI: 10.1016/S0959-4388(03)00008-4  1
2003 Olsen O, Bredt DS. Functional analysis of the nucleotide binding domain of membrane-associated guanylate kinases. The Journal of Biological Chemistry. 278: 6873-8. PMID 12482754 DOI: 10.1074/jbc.M210165200  1
2003 Bredt DS. Nitric oxide signaling specificity--the heart of the problem. Journal of Cell Science. 116: 9-15. PMID 12456711 DOI: 10.1242/jcs.00183  1
2002 Misawa H, Sherr EH, Lee DJ, Chetkovich DM, Tan A, Schreiner CE, Bredt DS. Identification of a monogenic locus (jams1) causing juvenile audiogenic seizures in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10088-93. PMID 12451109  1
2002 Klöcker N, Bunn RC, Schnell E, Caruana G, Bernstein A, Nicoll RA, Bredt DS. Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97. The European Journal of Neuroscience. 16: 1517-22. PMID 12405965 DOI: 10.1046/j.1460-9568.2002.02228.x  1
2002 el-Husseini Ael-D, Bredt DS. Protein palmitoylation: a regulator of neuronal development and function. Nature Reviews. Neuroscience. 3: 791-802. PMID 12360323 DOI: 10.1038/nrn940  1
2002 Schnell E, Sizemore M, Karimzadegan S, Chen L, Bredt DS, Nicoll RA. Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proceedings of the National Academy of Sciences of the United States of America. 99: 13902-7. PMID 12359873 DOI: 10.1073/pnas.172511199  1
2002 Kanaani J, el-Husseini Ael-D, Aguilera-Moreno A, Diacovo JM, Bredt DS, Baekkeskov S. A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65. The Journal of Cell Biology. 158: 1229-38. PMID 12356867 DOI: 10.1083/jcb.200205053  1
2002 Chetkovich DM, Bunn RC, Kuo SH, Kawasaki Y, Kohwi M, Bredt DS. Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6415-25. PMID 12151521  1
2002 Chetkovich DM, Chen L, Stocker TJ, Nicoll RA, Bredt DS. Phosphorylation of the postsynaptic density-95 (PSD-95)/discs large/zona occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 5791-6. PMID 12122038  1
2002 El-Husseini Ael-D, Schnell E, Dakoji S, Sweeney N, Zhou Q, Prange O, Gauthier-Campbell C, Aguilera-Moreno A, Nicoll RA, Bredt DS. Synaptic strength regulated by palmitate cycling on PSD-95. Cell. 108: 849-63. PMID 11955437 DOI: 10.1016/S0092-8674(02)00683-9  1
2002 Olsen O, Liu H, Wade JB, Merot J, Welling PA. Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex. American Journal of Physiology. Cell Physiology. 282: C183-95. PMID 11742811 DOI: 10.1152/ajpcell.00249.2001  1
2001 McGee AW, Dakoji SR, Olsen O, Bredt DS, Lim WA, Prehoda KE. Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins. Molecular Cell. 8: 1291-301. PMID 11779504 DOI: 10.1016/S1097-2765(01)00411-7  1
2001 El-Husseini Ael-D, Craven SE, Brock SC, Bredt DS. Polarized targeting of peripheral membrane proteins in neurons. The Journal of Biological Chemistry. 276: 44984-92. PMID 11546762 DOI: 10.1074/jbc.M103049200  1
2001 Le Maout S, Welling PA, Brejon M, Olsen O, Merot J. Basolateral membrane expression of a K+ channel, Kir 2.3, is directed by a cytoplasmic COOH-terminal domain. Proceedings of the National Academy of Sciences of the United States of America. 98: 10475-80. PMID 11504929 DOI: 10.1073/pnas.181481098  1
2001 Lumsden A, Andreae L, Gilthorpe J, Lowell S, Schubert F, Hamann S, Reber PJ, Häusser M, Murthy VN, Wood JN, Bredt DS, Ashe J, Chafee M, Merchant H, Goodwin S, et al. Neurobiology. Current Opinion in Neurobiology. 11: 259-66. PMID 11399421  1
2001 Tomita S, Nicoll RA, Bredt DS. PDZ protein interactions regulating glutamate receptor function and plasticity. The Journal of Cell Biology. 153: F19-24. PMID 11381098  1
2001 McGee AW, Topinka JR, Hashimoto K, Petralia RS, Kakizawa S, Kauer FW, Aguilera-Moreno A, Wenthold RJ, Kano M, Bredt DS, Kauer F. PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3085-91. PMID 11312293  1
2001 Aoki C, Miko I, Oviedo H, Mikeladze-Dvali T, Alexandre L, Sweeney N, Bredt DS. Electron microscopic immunocytochemical detection of PSD-95, PSD-93, SAP-102, and SAP-97 at postsynaptic, presynaptic, and nonsynaptic sites of adult and neonatal rat visual cortex. Synapse (New York, N.Y.). 40: 239-57. PMID 11309840 DOI: 10.1002/syn.1047  1
2001 Zhuang W, Eby JC, Cheong M, Mohapatra PK, Bredt DS, Disatnik MH, Rando TA. The susceptibility of muscle cells to oxidative stress is independent of nitric oxide synthase expression. Muscle & Nerve. 24: 502-11. PMID 11268022 DOI: 10.1002/mus.1033  1
2001 Jo K, Rutten B, Bunn RC, Bredt DS. Actinin-associated LIM protein-deficient mice maintain normal development and structure of skeletal muscle. Molecular and Cellular Biology. 21: 1682-7. PMID 11238905 DOI: 10.1128/MCB.21.5.1682-1687.2001  1
2001 Misawa H, Kawasaki Y, Mellor J, Sweeney N, Jo K, Nicoll RA, Bredt DS. Contrasting localizations of MALS/LIN-7 PDZ proteins in brain and molecular compensation in knockout mice. The Journal of Biological Chemistry. 276: 9264-72. PMID 11104771 DOI: 10.1074/jbc.M009334200  1
2000 Chen L, Chetkovich DM, Petralia RS, Sweeney NT, Kawasaki Y, Wenthold RJ, Bredt DS, Nicoll RA. Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature. 408: 936-43. PMID 11140673 DOI: 10.1038/35050030  1
2000 Firestein BL, Craven SE, Bredt DS. Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domains. Neuroreport. 11: 3479-84. PMID 11095503  1
2000 El-Husseini AE, Schnell E, Chetkovich DM, Nicoll RA, Bredt DS. PSD-95 involvement in maturation of excitatory synapses. Science (New York, N.Y.). 290: 1364-8. PMID 11082065  1
2000 Tochio H, Mok YK, Zhang Q, Kan HM, Bredt DS, Zhang M. Formation of nNOS/PSD-95 PDZ dimer requires a preformed beta-finger structure from the nNOS PDZ domain. Journal of Molecular Biology. 303: 359-70. PMID 11031113 DOI: 10.1006/jmbi.2000.4148  1
2000 Perillán PR, Li X, Potts EA, Chen M, Bredt DS, Simard JM. Inward rectifier K(+) channel Kir2.3 (IRK3) in reactive astrocytes from adult rat brain. Glia. 31: 181-92. PMID 10878604 DOI: 10.1002/1098-1136(200008)31:2<181::AID-GLIA90>3.0.CO;2-8  1
2000 Lehrer-Graiwer JE, Firestein BL, Bredt DS. Nitric oxide mediated induction of cytochrome c oxidase mRNA and protein in a mouse macrophage cell line. Neuroscience Letters. 288: 107-10. PMID 10876072 DOI: 10.1016/S0304-3940(00)01205-2  1
2000 El-Husseini AE, Topinka JR, Lehrer-Graiwer JE, Firestein BL, Craven SE, Aoki C, Bredt DS. Ion channel clustering by membrane-associated guanylate kinases. Differential regulation by N-terminal lipid and metal binding motifs. The Journal of Biological Chemistry. 275: 23904-10. PMID 10779526 DOI: 10.1074/jbc.M909919199  1
2000 Bredt DS. Cell biology. Reeling CASK into the nucleus. Nature. 404: 241-2. PMID 10749196 DOI: 10.1038/35005208  1
2000 Craven SE, Bredt DS. Synaptic targeting of the postsynaptic density protein PSD-95 mediated by a tyrosine-based trafficking signal. The Journal of Biological Chemistry. 275: 20045-51. PMID 10748194 DOI: 10.1074/jbc.M910153199  1
2000 El-Husseini AE, Craven SE, Chetkovich DM, Firestein BL, Schnell E, Aoki C, Bredt DS. Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering. The Journal of Cell Biology. 148: 159-72. PMID 10629226 DOI: 10.1083/jcb.148.1.159  1
2000 Tochio H, Hung F, Li M, Bredt DS, Zhang M. Solution structure and backbone dynamics of the second PDZ domain of postsynaptic density-95. Journal of Molecular Biology. 295: 225-37. PMID 10623522 DOI: 10.1006/jmbi.1999.3350  1
1999 Bredt DS. Endogenous nitric oxide synthesis: biological functions and pathophysiology. Free Radical Research. 31: 577-96. PMID 10630682  1
1999 Firestein BL, Firestein BL, Brenman JE, Aoki C, Sanchez-Perez AM, El-Husseini AE, Bredt DS. Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting. Neuron. 24: 659-72. PMID 10595517  1
1999 Bredt DS. Knocking signalling out of the dystrophin complex. Nature Cell Biology. 1: E89-91. PMID 10559928 DOI: 10.1038/12085  1
1999 Christopherson KS, Hillier BJ, Lim WA, Bredt DS. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. The Journal of Biological Chemistry. 274: 27467-73. PMID 10488080 DOI: 10.1074/jbc.274.39.27467  1
1999 McGee AW, Bredt DS. Identification of an intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95. The Journal of Biological Chemistry. 274: 17431-6. PMID 10364172 DOI: 10.1074/jbc.274.25.17431  1
1999 Jo K, Derin R, Li M, Bredt DS. Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 4189-99. PMID 10341223  1
1999 Roche KW, Ly CD, Petralia RS, Wang YX, McGee AW, Bredt DS, Wenthold RJ. Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 3926-34. PMID 10234023  1
1999 Hillier BJ, Christopherson KS, Prehoda KE, Bredt DS, Lim WA. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science (New York, N.Y.). 284: 812-5. PMID 10221915 DOI: 10.1126/science.284.5415.812  1
1999 Tojo A, Bredt DS, Wilcox CS. Distribution of postsynaptic density proteins in rat kidney: relationship to neuronal nitric oxide synthase. Kidney International. 55: 1384-94. PMID 10201003 DOI: 10.1046/j.1523-1755.1999.00392.x  1
1999 Craven SE, El-Husseini AE, Bredt DS. Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs. Neuron. 22: 497-509. PMID 10197530  1
1999 Firestein BL, Bredt DS. Interaction of neuronal nitric-oxide synthase and phosphofructokinase-M. The Journal of Biological Chemistry. 274: 10545-50. PMID 10187848 DOI: 10.1074/jbc.274.15.10545  1
1999 Xu KY, Huso DL, Dawson TM, Bredt DS, Becker LC. Nitric oxide synthase in cardiac sarcoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America. 96: 657-62. PMID 9892689 DOI: 10.1073/pnas.96.2.657  1
1998 Reid MB, Kobzik L, Bredt DS, Stamler JS. Nitric oxide modulates excitation-contraction coupling in the diaphragm. Comparative Biochemistry and Physiology. Part a, Molecular & Integrative Physiology. 119: 211-8. PMID 11253787 DOI: 10.1016/S1095-6433(97)00417-0  1
1998 Aoki C, Bredt DS, Fenstemaker S, Lubin M. The subcellular distribution of nitric oxide synthase relative to the NR1 subunit of NMDA receptors in the cerebral cortex. Progress in Brain Research. 118: 83-97. PMID 9932436  1
1998 Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL, Bredt DS, Gale NW, Yancopoulos GD. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron. 21: 1453-63. PMID 9883737 DOI: 10.1016/S0896-6273(00)80663-7  1
1998 Perez AS, Bredt DS. The N-terminal PDZ-containing region of postsynaptic density-95 mediates association with caveolar-like lipid domains. Neuroscience Letters. 258: 121-3. PMID 9875542 DOI: 10.1016/S0304-3940(98)00846-5  1
1998 Bredt DS. NO skeletal muscle derived relaxing factor in Duchenne muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America. 95: 14592-3. PMID 9843933 DOI: 10.1073/pnas.95.25.14592  1
1998 Koulen P, Fletcher EL, Craven SE, Bredt DS, Wässle H. Immunocytochemical localization of the postsynaptic density protein PSD-95 in the mammalian retina. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 10136-49. PMID 9822767  1
1998 Firestein BL, Bredt DS. Regulation of sensory neuron precursor proliferation by cyclic GMP-dependent protein kinase. Journal of Neurochemistry. 71: 1846-53. PMID 9798908  1
1998 Brenman JE, Topinka JR, Cooper EC, McGee AW, Rosen J, Milroy T, Ralston HJ, Bredt DS. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 8805-13. PMID 9786987  1
1998 Bredt DS. Sorting out genes that regulate epithelial and neuronal polarity. Cell. 94: 691-4. PMID 9753315 DOI: 10.1016/S0092-8674(00)81727-4  1
1998 Chao DS, Silvagno F, Bredt DS. Muscular dystrophy in mdx mice despite lack of neuronal nitric oxide synthase. Journal of Neurochemistry. 71: 784-9. PMID 9681470  1
1998 Morton DB, Bredt DS. Norepinephrine increases cyclic GMP levels in cerebellar cells from neuronal nitric oxide synthase knockout mice. Journal of Neurochemistry. 71: 440-3. PMID 9648894  1
1998 El Dwairi Q, Guo Y, Comtois A, Zhu E, Greenwood MT, Bredt DS, Hussain SN. Ontogenesis of nitric oxide synthases in the ventilatory muscles. American Journal of Respiratory Cell and Molecular Biology. 18: 844-52. PMID 9618389  1
1998 Craven SE, Bredt DS. PDZ proteins organize synaptic signaling pathways. Cell. 93: 495-8. PMID 9604925 DOI: 10.1016/S0092-8674(00)81179-4  1
1998 Topinka JR, Bredt DS. N-terminal palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+ channel Kv1.4. Neuron. 20: 125-34. PMID 9459448 DOI: 10.1016/S0896-6273(00)80440-7  1
1997 Le Maout S, Brejon M, Olsen O, Merot J, Welling PA. Basolateral membrane targeting of a renal-epithelial inwardly rectifying potassium channel from the cortical collecting duct, CCD-IRK3, in MDCK cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 13329-34. PMID 9371845 DOI: 10.1073/pnas.94.24.13329  1
1997 Christopherson KS, Bredt DS. Nitric oxide in excitable tissues: physiological roles and disease. The Journal of Clinical Investigation. 100: 2424-9. PMID 9366555 DOI: 10.1172/JCI119783  1
1997 Xia H, Winokur ST, Kuo WL, Altherr MR, Bredt DS. Actinin-associated LIM protein: identification of a domain interaction between PDZ and spectrin-like repeat motifs. The Journal of Cell Biology. 139: 507-15. PMID 9334352 DOI: 10.1083/jcb.139.2.507  1
1997 Brenman JE, Bredt DS. Synaptic signaling by nitric oxide. Current Opinion in Neurobiology. 7: 374-8. PMID 9232800 DOI: 10.1016/S0959-4388(97)80065-7  1
1997 Brenman JE, Xia H, Chao DS, Black SM, Bredt DS. Regulation of neuronal nitric oxide synthase through alternative transcripts. Developmental Neuroscience. 19: 224-31. PMID 9208206  0.52
1997 Xia H, Fitzgerald J, Bredt DS, Forsayeth JR. Detection of mycoplasma infection of mammalian cells. Biotechniques. 22: 934-6. PMID 9149878  1
1997 Chao DS, Silvagno F, Xia H, Cornwell TL, Lincoln TM, Bredt DS. Nitric oxide synthase and cyclic GMP-dependent protein kinase concentrated at the neuromuscular endplate. Neuroscience. 76: 665-72. PMID 9135041 DOI: 10.1016/S0306-4522(96)00367-3  1
1997 Cobbs CS, Fenoy A, Bredt DS, Noble LJ. Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat. Brain Research. 751: 336-8. PMID 9099824 DOI: 10.1016/S0006-8993(96)01429-1  1
1997 Stricker NL, Christopherson KS, Yi BA, Schatz PJ, Raab RW, Dawes G, Bassett DE, Bredt DS, Li M. PDZ domain of neuronal nitric oxide synthase recognizes novel C-terminal peptide sequences. Nature Biotechnology. 15: 336-42. PMID 9094134 DOI: 10.1038/nbt0497-336  1
1997 Sutherland RS, Kogan BA, Piechota HJ, Bredt DS. Vesicourethral function in mice with genetic disruption of neuronal nitric oxide synthase. The Journal of Urology. 157: 1109-16. PMID 9072553 DOI: 10.1016/S0022-5347(01)65151-6  1
1997 Bredt D, Murphy S. Preface Developmental Neuroscience. 19: 223.  1
1996 Bredt DS. NO NMDA receptor activity. Nature Biotechnology. 14: 944. PMID 9631029 DOI: 10.1038/nbt0896-944  1
1996 Brenman JE, Christopherson KS, Craven SE, McGee AW, Bredt DS. Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 7407-15. PMID 8922396  1
1996 Cohen NA, Brenman JE, Snyder SH, Bredt DS. Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation. Neuron. 17: 759-67. PMID 8893032 DOI: 10.1016/S0896-6273(00)80207-X  1
1996 Holtzman DM, Lee S, Li Y, Chua-Couzens J, Xia H, Bredt DS, Mobley WC. Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: regulation by NGF. Neurochemical Research. 21: 861-8. PMID 8873091  1
1996 Brenman JE, Bredt DS. Nitric oxide signaling in the nervous system. Methods in Enzymology. 269: 119-29. PMID 8791642  1
1996 Chao DS, Hwang PM, Huang F, Bredt DS. Localization of neuronal nitric oxide synthase. Methods in Enzymology. 268: 488-96. PMID 8782614  1
1996 Xia H, Bredt DS. Cloned and expressed nitric oxide synthase proteins. Methods in Enzymology. 268: 427-36. PMID 8782609  1
1996 Chao DS, Gorospe JR, Brenman JE, Rafael JA, Peters MF, Froehner SC, Hoffman EP, Chamberlain JS, Bredt DS. Selective loss of sarcolemmal nitric oxide synthase in Becker muscular dystrophy. The Journal of Experimental Medicine. 184: 609-18. PMID 8760814  1
1996 Qian Y, Chao DS, Santillano DR, Cornwell TL, Nairn AC, Greengard P, Lincoln TM, Bredt DS. cGMP-dependent protein kinase in dorsal root ganglion: relationship with nitric oxide synthase and nociceptive neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 3130-8. PMID 8627352  1
1996 Silvagno F, Xia H, Bredt DS. Neuronal nitric-oxide synthase-mu, an alternatively spliced isoform expressed in differentiated skeletal muscle. The Journal of Biological Chemistry. 271: 11204-8. PMID 8626668  1
1996 Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, Huang F, Xia H, Peters MF, Froehner SC, Bredt DS. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell. 84: 757-67. PMID 8625413 DOI: 10.1016/S0092-8674(00)81053-3  1
1996 Bredt DS. Targeting nitric oxide to its targets. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 211: 41-8. PMID 8594617  1
1995 Bredt DS, Wang TL, Cohen NA, Guggino WB, Snyder SH. Cloning and expression of two brain-specific inwardly rectifying potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 92: 6753-7. PMID 7624316 DOI: 10.1073/pnas.92.15.6753  1
1995 Brenman JE, Chao DS, Xia H, Aldape K, Bredt DS. Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. Cell. 82: 743-52. PMID 7545544 DOI: 10.1016/0092-8674(95)90471-9  1
1995 Bischof G, Brenman J, Bredt DS, Machen TE. Possible regulation of capacitative Ca2+ entry into colonic epithelial cells by NO and cGMP. Cell Calcium. 17: 250-62. PMID 7545090 DOI: 10.1016/0143-4160(95)90071-3  1
1995 Burnett AL, Ricker DD, Chamness SL, Maguire MP, Crone JK, Bredt DS, Snyder SH, Chang TS. Localization of nitric oxide synthase in the reproductive organs of the male rat. Biology of Reproduction. 52: 1-7. PMID 7536043 DOI: 10.1095/biolreprod52.1.1  1
1995 Cobbs CS, Brenman JE, Aldape KD, Bredt DS, Israel MA. Expression of nitric oxide synthase in human central nervous system tumors. Cancer Research. 55: 727-30. PMID 7531613  1
1994 Holtzman DM, Kilbridge J, Bredt DS, Black SM, Li Y, Clary DO, Reichardt LF, Mobley WC. NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin. Neurobiology of Disease. 1: 51-60. PMID 9216986 DOI: 10.1006/nbdi.1994.0007  1
1994 Wang ZZ, Stensaas LJ, Bredt DS, Dinger BG, Fidone SJ. Mechanisms of carotid body inhibition. Advances in Experimental Medicine and Biology. 360: 229-35. PMID 7532901  1
1994 Kobzik L, Reid MB, Bredt DS, Stamler JS. Nitric oxide in skeletal muscle. Nature. 372: 546-8. PMID 7527495 DOI: 10.1038/372546a0  1
1994 Bredt DS, Snyder SH. Nitric oxide: a physiologic messenger molecule. Annual Review of Biochemistry. 63: 175-95. PMID 7526779 DOI: 10.1146/annurev.bi.63.070194.001135  1
1994 Slivka A, Chuttani R, Carr-Locke DL, Kobzik L, Bredt DS, Loscalzo J, Stamler JS. Inhibition of sphincter of Oddi function by the nitric oxide carrier S-nitroso-N-acetylcysteine in rabbits and humans. The Journal of Clinical Investigation. 94: 1792-8. PMID 7525649 DOI: 10.1172/JCI117527  1
1994 Villar MJ, Ceccatelli S, Bedecs K, Bartfai T, Bredt D, Synder SH, Hökfelt T. Upregulation of nitric oxide synthase and galanin message-associated peptide in hypothalamic magnocellular neurons after hypophysectomy. Immunohistochemical and in situ hybridization studies. Brain Research. 650: 219-28. PMID 7525016 DOI: 10.1016/0006-8993(94)91785-X  1
1994 Bredt DS, Snyder SH. Transient nitric oxide synthase neurons in embryonic cerebral cortical plate, sensory ganglia, and olfactory epithelium. Neuron. 13: 301-13. PMID 7520252 DOI: 10.1016/0896-6273(94)90348-4  1
1994 Roskams AJ, Bredt DS, Dawson TM, Ronnett GV. Nitric oxide mediates the formation of synaptic connections in developing and regenerating olfactory receptor neurons. Neuron. 13: 289-99. PMID 7520251 DOI: 10.1016/0896-6273(94)90347-6  1
1994 Wang ZZ, Stensaas LJ, Bredt DS, Dinger B, Fidone SJ. Localization and actions of nitric oxide in the cat carotid body. Neuroscience. 60: 275-86. PMID 7519759 DOI: 10.1016/0306-4522(94)90221-6  1
1994 Saito S, Kidd GJ, Trapp BD, Dawson TM, Bredt DS, Wilson DA, Traystman RJ, Snyder SH, Hanley DF. Rat spinal cord neurons contain nitric oxide synthase. Neuroscience. 59: 447-56. PMID 7516502 DOI: 10.1016/0306-4522(94)90608-4  1
1994 Toda N, Kimura T, Yoshida K, Bredt DS, Snyder SH, Yoshida Y, Okamura T. Human uterine arterial relaxation induced by nitroxidergic nerve stimulation. The American Journal of Physiology. 266: H1446-50. PMID 7514361  1
1994 Berezin I, Snyder SH, Bredt DS, Daniel EE. Ultrastructural localization of nitric oxide synthase in canine small intestine and colon. The American Journal of Physiology. 266: C981-9. PMID 7513956  1
1993 Hwang PM, Fotuhi M, Bredt DS, Cunningham AM, Snyder SH. Contrasting immunohistochemical localizations in rat brain of two novel K+ channels of the Shab subfamily. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 1569-76. PMID 8463836  1
1993 Nishikawa T, Kirsch JR, Koehler RC, Bredt DS, Snyder SH, Traystman RJ. Effect of nitric oxide synthase inhibition on cerebral blood flow and injury volume during focal ischemia in cats. Stroke; a Journal of Cerebral Circulation. 24: 1717-24. PMID 7694394  1
1993 Zhang X, Verge V, Wiesenfeld-Hallin Z, Ju G, Bredt D, Synder SH, Hökfelt T. Nitric oxide synthase-like immunoreactivity in lumbar dorsal root ganglia and spinal cord of rat and monkey and effect of peripheral axotomy. The Journal of Comparative Neurology. 335: 563-75. PMID 7693774 DOI: 10.1002/cne.903350408  1
1993 Kobzik L, Bredt DS, Lowenstein CJ, Drazen J, Gaston B, Sugarbaker D, Stamler JS. Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. American Journal of Respiratory Cell and Molecular Biology. 9: 371-7. PMID 7691109 DOI: 10.1165/ajrcmb/9.4.371  1
1993 Anderson CR, Edwards SL, Furness JB, Bredt DS, Snyder SH. The distribution of nitric oxide synthase-containing autonomic preganglionic terminals in the rat. Brain Research. 614: 78-85. PMID 7688648 DOI: 10.1016/0006-8993(93)91020-S  1
1993 Yamamoto R, Bredt DS, Snyder SH, Stone RA. The localization of nitric oxide synthase in the rat eye and related cranial ganglia. Neuroscience. 54: 189-200. PMID 7685860 DOI: 10.1016/0306-4522(93)90393-T  1
1993 Burnett AL, Tillman SL, Chang TS, Epstein JI, Lowenstein CJ, Bredt DS, Snyder SH, Walsh PC. Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis. The Journal of Urology. 150: 73-6. PMID 7685426  1
1993 Breslow MJ, Tobin JR, Bredt DS, Ferris CD, Snyder SH, Traystman RJ. Nitric oxide as a regulator of adrenal blood flow. The American Journal of Physiology. 264: H464-9. PMID 7680537  1
1993 Nozaki K, Moskowitz MA, Maynard KI, Koketsu N, Dawson TM, Bredt DS, Snyder SH. Possible origins and distribution of immunoreactive nitric oxide synthase-containing nerve fibers in cerebral arteries. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 13: 70-9. PMID 7678014 DOI: 10.1038/jcbfm.1993.9  1
1993 Yamamoto R, Bredt DS, Dawson TM, Snyder SH, Stone RA. Enhanced expression of nitric oxide synthase by rat retina following pterygopalatine parasympathetic denervation. Brain Research. 631: 83-8. PMID 7507791 DOI: 10.1016/0006-8993(93)91190-4  1
1993 Yoshida K, Okamura T, Kimura H, Bredt DS, Snyder SH, Toda N. Nitric oxide synthase-immunoreactive nerve fibers in dog cerebral and peripheral arteries. Brain Research. 629: 67-72. PMID 7506984 DOI: 10.1016/0006-8993(93)90482-3  1
1993 Huang PL, Dawson TM, Bredt DS, Snyder SH, Fishman MC. Targeted disruption of the neuronal nitric oxide synthase gene. Cell. 75: 1273-86. PMID 7505721 DOI: 10.1016/0092-8674(93)90615-W  1
1993 Wang ZZ, Bredt DS, Fidone SJ, Stensaas LJ. Neurons synthesizing nitric oxide innervate the mammalian carotid body. The Journal of Comparative Neurology. 336: 419-32. PMID 7505296 DOI: 10.1002/cne.903360308  1
1992 Hwang PM, Glatt CE, Bredt DS, Yellen G, Snyder SH. A novel K+ channel with unique localizations in mammalian brain: molecular cloning and characterization. Neuron. 8: 473-81. PMID 1550672 DOI: 10.1016/0896-6273(92)90275-I  1
1992 Ceccatelli S, Lundberg JM, Fahrenkrug J, Bredt DS, Snyder SH, Hökfelt T. Evidence for involvement of nitric oxide in the regulation of hypothalamic portal blood flow. Neuroscience. 51: 769-72. PMID 1488122 DOI: 10.1016/0306-4522(92)90518-7  1
1992 Ward SM, Xue C, Shuttleworth CW, Bredt DS, Snyder SH, Sanders KM. NADPH diaphorase and nitric oxide synthase colocalization in enteric neurons of canine proximal colon. The American Journal of Physiology. 263: G277-84. PMID 1381151  1
1992 Lowenstein CJ, Glatt CS, Bredt DS, Snyder SH. Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proceedings of the National Academy of Sciences of the United States of America. 89: 6711-5. PMID 1379716  1
1992 Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH. Nitric oxide: a physiologic mediator of penile erection. Science (New York, N.Y.). 257: 401-3. PMID 1378650  1
1992 Young HM, Furness JB, Shuttleworth CW, Bredt DS, Snyder SH. Co-localization of nitric oxide synthase immunoreactivity and NADPH diaphorase staining in neurons of the guinea-pig intestine. Histochemistry. 97: 375-8. PMID 1377664 DOI: 10.1007/BF00270041  1
1992 Llewellyn-Smith IJ, Song ZM, Costa M, Bredt DS, Snyder SH. Ultrastructural localization of nitric oxide synthase immunoreactivity in guinea-pig enteric neurons. Brain Research. 577: 337-42. PMID 1376636 DOI: 10.1016/0006-8993(92)90294-J  1
1992 Breslow MJ, Tobin JR, Bredt DS, Ferris CD, Snyder SH, Traystman RJ. Role of nitric oxide in adrenal medullary vasodilation during catecholamine secretion. European Journal of Pharmacology. 210: 105-6. PMID 1376270 DOI: 10.1016/0014-2999(92)90659-R  1
1992 Bredt DS, Ferris CD, Snyder SH. Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. The Journal of Biological Chemistry. 267: 10976-81. PMID 1375933  1
1992 Snyder SH, Bredt DS. Biological roles of nitric oxide. Scientific American. 266: 68-71, 74-7. PMID 1373517  1
1992 Bredt DS, Snyder SH. Nitric oxide, a novel neuronal messenger. Neuron. 8: 3-11. PMID 1370373 DOI: 10.1016/0896-6273(92)90104-L  1
1992 Ferris CD, Cameron AM, Bredt DS, Huganir RL, Snyder SH. Autophosphorylation of inositol 1,4,5-trisphosphate receptors. The Journal of Biological Chemistry. 267: 7036-41. PMID 1313030  1
1992 Costa M, Furness JB, Pompolo S, Brookes SJ, Bornstein JC, Bredt DS, Snyder SH. Projections and chemical coding of neurons with immunoreactivity for nitric oxide synthase in the guinea-pig small intestine. Neuroscience Letters. 148: 121-5. PMID 1284439 DOI: 10.1016/0304-3940(92)90819-S  1
1992 Hyman BT, Marzloff K, Wenniger JJ, Dawson TM, Bredt DS, Snyder SH. Relative sparing of nitric oxide synthase-containing neurons in the hippocampal formation in Alzheimer's disease. Annals of Neurology. 32: 818-20. PMID 1281971 DOI: 10.1002/ana.410320618  1
1992 McMillan K, Bredt DS, Hirsch DJ, Snyder SH, Clark JE, Masters BS. Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide. Proceedings of the National Academy of Sciences of the United States of America. 89: 11141-5. PMID 1280819  1
1992 Pou S, Pou WS, Bredt DS, Snyder SH, Rosen GM. Generation of superoxide by purified brain nitric oxide synthase. The Journal of Biological Chemistry. 267: 24173-6. PMID 1280257  1
1991 Reinlib L, Homaidan F, Watson A, Bredt DS, Sharp GW, Zahniser D, Donowitz M. Uncoupling of phospholipase C from receptor regulation of [Ca2+]i in T84 colonic cells by prolonged exposure to phorbol dibutyrate. The Journal of Biological Chemistry. 266: 17904-11. PMID 1917930  1
1991 Ferris CD, Huganir RL, Bredt DS, Cameron AM, Snyder SH. Inositol trisphosphate receptor: phosphorylation by protein kinase C and calcium calmodulin-dependent protein kinases in reconstituted lipid vesicles. Proceedings of the National Academy of Sciences of the United States of America. 88: 2232-5. PMID 1848697  1
1991 Ferris CD, Cameron AM, Bredt DS, Huganir RL, Snyder SH. Inositol 1,4,5-trisphosphate receptor is phosphorylated by cyclic AMP-dependent protein kinase at serines 1755 and 1589. Biochemical and Biophysical Research Communications. 175: 192-8. PMID 1847804 DOI: 10.1016/S0006-291X(05)81219-7  1
1991 Bredt DS, Glatt CE, Hwang PM, Fotuhi M, Dawson TM, Snyder SH. Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron. 7: 615-24. PMID 1718335 DOI: 10.1016/0896-6273(91)90374-9  1
1991 Dawson TM, Bredt DS, Fotuhi M, Hwang PM, Snyder SH. Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proceedings of the National Academy of Sciences of the United States of America. 88: 7797-801. PMID 1715581  1
1991 Snyder SH, Bredt DS. Nitric oxide as a neuronal messenger. Trends in Pharmacological Sciences. 12: 125-8. PMID 1712138 DOI: 10.1016/0165-6147(91)90526-X  1
1991 Bredt DS, Hwang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature. 351: 714-8. PMID 1712077 DOI: 10.1038/351714a0  1
1991 Dwyer MA, Bredt DS, Snyder SH. Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo. Biochemical and Biophysical Research Communications. 176: 1136-41. PMID 1710109 DOI: 10.1016/0006-291X(91)90403-T  1
1991 Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proceedings of the National Academy of Sciences of the United States of America. 88: 6368-71. PMID 1648740  1
1990 Hwang PM, Verma A, Bredt DS, Snyder SH. Localization of phosphatidylinositol signaling components in rat taste cells: role in bitter taste transduction. Proceedings of the National Academy of Sciences of the United States of America. 87: 7395-9. PMID 2217172  1
1990 Hwang PM, Bredt DS, Snyder SH. Autoradiographic imaging of phosphoinositide turnover in the brain. Science (New York, N.Y.). 249: 802-4. PMID 1975122  1
1990 Bredt DS, Hwang PM, Snyder SH. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature. 347: 768-70. PMID 1700301 DOI: 10.1038/347768a0  1
1990 Ross CA, Bredt D, Snyder SH. Messenger molecules in the cerebellum. Trends in Neurosciences. 13: 216-22. PMID 1694327 DOI: 10.1016/0166-2236(90)90163-5  1
1990 Bredt DS, Snyder SH. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proceedings of the National Academy of Sciences of the United States of America. 87: 682-5. PMID 1689048  1
1989 Bredt DS, Snyder SH. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proceedings of the National Academy of Sciences of the United States of America. 86: 9030-3. PMID 2573074 DOI: 10.1073/pnas.86.22.9030  1
1989 Kuby SA, Hamada M, Johnson MS, Russell GA, Manship M, Palmieri RH, Fleming G, Bredt DS, Mildvan AS. Studies on adenosine triphosphate transphosphorylases. XVIII. Synthesis and preparation of peptides and peptide fragments of rabbit muscle ATP-AMP transphosphorylase (adenylate kinase) and their nucleotide-binding properties. Journal of Protein Chemistry. 8: 549-62. PMID 2553049 DOI: 10.1007/BF01026438  1
1989 Bredt DS, Mourey RJ, Snyder SH. A simple, sensitive, and specific radioreceptor assay for inositol 1,4,5-trisphosphate in biological tissues. Biochemical and Biophysical Research Communications. 159: 976-82. PMID 2539157 DOI: 10.1016/0006-291X(89)92204-3  1
1988 Frankel AD, Bredt DS, Pabo CO. Tat protein from human immunodeficiency virus forms a metal-linked dimer. Science (New York, N.Y.). 240: 70-3. PMID 2832944  1
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