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Roderick MacKinnon - Related publications

Affiliations: 
Rockefeller University, New York, NY, United States 
Area:
Ion channels
Website:
https://www.rockefeller.edu/our-scientists/heads-of-laboratories/872-roderick-mackinnon/
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Fletcher-Taylor S, Thapa P, Sepela RJ, Kaakati R, Yarov-Yarovoy V, Sack JT, Cohen BE. Distinguishing Potassium Channel Resting State Conformations in Live Cells with Environment-Sensitive Fluorescence. Acs Chemical Neuroscience. PMID 32579336 DOI: 10.1021/acschemneuro.0c00276   
2020 Hasan S, Megaro A, Cenciarini M, Coretti L, Botti FM, Imbrici P, Steinbusch HWM, Hunter T, Hunter G, Pessia M, D'Adamo MC. Electromechanical coupling of the Kv1.1 voltage-gated K channel is fine-tuned by the simplest amino acid residue in the S4-S5 linker. Pflugers Archiv : European Journal of Physiology. PMID 32577860 DOI: 10.1007/s00424-020-02414-0   
2020 Yang W, Wang Y, Guo J, He L, Zhou Y, Zheng H, Liu Z, Zhu P, Zhang XC. Cryo-EM structure of CLHM1 ion channel from Caenorhabditis elegans. Protein Science : a Publication of the Protein Society. PMID 32557855 DOI: 10.1002/pro.3904   
2020 Clark MD, Contreras GF, Shen R, Perozo E. Electromechanical coupling in the hyperpolarization-activated K channel KAT1. Nature. PMID 32461693 DOI: 10.1038/s41586-020-2335-4   
2020 Garza-López E, Aldana A, Darszon A, Nishigaki T, López-González I. Ca3.1 channel pore pseudo-symmetry revealed by selectivity filter mutations in its domains I/II. Cell Calcium. 89: 102214. PMID 32428730 DOI: 10.1016/j.ceca.2020.102214   
2020 Li C, Chen H, Chen Q, Shi H, Yang X, Wang K, Liu J. Lipophilic G-quadruplex Isomers as Biomimetic Ion Channels for Conformation- dependent Selective Transmembrane Transport. Analytical Chemistry. PMID 32564593 DOI: 10.1021/acs.analchem.0c02222   
2020 Fagnen C, Bannwarth L, Oubella I, Forest E, De Zorzi R, de Araujo A, Mhoumadi Y, Bendahhou S, Perahia D, Vénien-Bryan C. New Structural insights into Kir channel gating from molecular simulations, HDX-MS and functional studies. Scientific Reports. 10: 8392. PMID 32439887 DOI: 10.1038/s41598-020-65246-z   
2020 Chen X, Bründl M, Friesacher T, Stary-Weinzinger A. Computational Insights Into Voltage Dependence of Polyamine Block in a Strong Inwardly Rectifying K Channel. Frontiers in Pharmacology. 11: 721. PMID 32499707 DOI: 10.3389/fphar.2020.00721   
2020 Gao J, Wei H, Cano A, Kurgan L. PSIONplus Server for Accurate Multi-Label Prediction of Ion Channels and Their Types. Biomolecules. 10. PMID 32517331 DOI: 10.3390/biom10060876   
2020 Sancho M, Welsh DG. K channels in the microvasculature: Regulatory properties and the lipid-hemodynamic environment. Current Topics in Membranes. 85: 227-259. PMID 32402641 DOI: 10.1016/bs.ctm.2020.01.006   
2020 Kwon Y, Haam CE, Byeon S, Choi SJ, Shin DH, Choi SK, Lee YH. Vasodilatory Effect of Extract in Rat Mesenteric Arteries. Molecules (Basel, Switzerland). 25. PMID 32664327 DOI: 10.3390/molecules25143160   
2020 Geragotelis AD, Wood ML, Göddeke H, Hong L, Webster PD, Wong EK, Freites JA, Tombola F, Tobias DJ. Voltage-dependent structural models of the human Hv1 proton channel from long-timescale molecular dynamics simulations. Proceedings of the National Academy of Sciences of the United States of America. PMID 32461356 DOI: 10.1073/pnas.1920943117   
2020 Al-Sabi A, Daly D, Rooney M, Hughes C, Kinsella GK, Kaza SK, Nolan K, Oliver Dolly J. Development of a selective inhibitor for Kv1.1 channels prevalent in demyelinated nerves. Bioorganic Chemistry. 100: 103918. PMID 32428746 DOI: 10.1016/j.bioorg.2020.103918   
2020 Ruan Z, Orozco IJ, Du J, Lü W. Structures of human pannexin 1 reveal ion pathways and mechanism of gating. Nature. PMID 32494015 DOI: 10.1038/s41586-020-2357-y   
2020 Cai S, Tuohy P, Ma C, Kitamura N, Gomez K, Zhou Y, Ran D, Bellampalli SS, Yu J, Luo S, Dorame A, Ngan Pham NY, Molnar G, Streicher JM, Patek M, et al. A modulator of the low-voltage activated T-type calcium channel that reverses HIV glycoprotein 120-, paclitaxel-, and spinal nerve ligation-induced peripheral neuropathies. Pain. PMID 32541387 DOI: 10.1097/j.pain.0000000000001955   
2020 Rödström KEJ, Kiper AK, Zhang W, Rinné S, Pike ACW, Goldstein M, Conrad LJ, Delbeck M, Hahn MG, Meier H, Platzk M, Quigley A, Speedman D, Shrestha L, Mukhopadhyay SMM, et al. A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature. PMID 32499642 DOI: 10.1038/s41586-020-2250-8   
2020 Hernandez A, Hernández-Centeno R, Espino-Saldaña ÁE, Martínez-Torres A. HCN2 activation modulation: An electrophysiological and molecular study of the well-preserved LCI sequence in the pore channel. Archives of Biochemistry and Biophysics. 108436. PMID 32492375 DOI: 10.1016/j.abb.2020.108436   
2020 Mudumbi KC, Czapiewski R, Ruba A, Junod SL, Li Y, Luo W, Ngo C, Ospina V, Schirmer EC, Yang W. Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores. Nature Communications. 11: 2184. PMID 32366843 DOI: 10.1038/s41467-020-16033-x   
2020 Zheng X, Fu Z, Su D, Zhang Y, Li M, Pan Y, Li H, Li S, Grassucci RA, Ren Z, Hu Z, Li X, Zhou M, Li G, Frank J, et al. Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Nature Structural & Molecular Biology. PMID 32483338 DOI: 10.1038/s41594-020-0433-5   
2020 Hou J, Daniels PN, Burke MD. Small Molecule Channels Harness Membrane Potential to Concentrate Potassium in trk1Δtrk2Δ Yeast. Acs Chemical Biology. PMID 32427463 DOI: 10.1021/acschembio.0c00180   
2020 Pai VP, Cervera J, Mafe S, Willocq V, Lederer EK, Levin M. HCN2 Channel-Induced Rescue of Brain Teratogenesis Local and Long-Range Bioelectric Repair. Frontiers in Cellular Neuroscience. 14: 136. PMID 32528251 DOI: 10.3389/fncel.2020.00136   
2020 Szanto TG, Zakany F, Papp F, Varga Z, Deutsch CJ, Panyi G. The activation gate controls steady-state inactivation and recovery from inactivation in Shaker. The Journal of General Physiology. 152. PMID 32442242 DOI: 10.1085/jgp.202012591   
2020 Zhu W, Li T, Silva JR, Chen J. Conservation and divergence in NaChBac and Na1.7 pharmacology reveals novel drug interaction mechanisms. Scientific Reports. 10: 10730. PMID 32612253 DOI: 10.1038/s41598-020-67761-5   
2020 Benítez-Angeles M, Morales-Lázaro SL, Juárez-González E, Rosenbaum T. TRPV1: Structure, Endogenous Agonists, and Mechanisms. International Journal of Molecular Sciences. 21. PMID 32408609 DOI: 10.3390/ijms21103421   
2020 Liu Y, Mikrani R, He Y, Faran Asraf Baig MM, Abbas M, Naveed M, Tang M, Zhang Q, Li C, Zhou X. TRPM8 channels: A review of distribution and clinical role. European Journal of Pharmacology. 173312. PMID 32610057 DOI: 10.1016/j.ejphar.2020.173312   
2020 Méndez-Reséndiz KA, Enciso-Pablo Ó, González-Ramírez R, Juárez-Contreras R, Rosenbaum T, Morales-Lázaro SL. Steroids and TRP Channels: A Close Relationship. International Journal of Molecular Sciences. 21. PMID 32471309 DOI: 10.3390/ijms21113819   
2020 Black KA, He S, Jin R, Miller DM, Bolla JR, Clarke OB, Johnson P, Windley M, Burns CJ, Hill AP, Laver D, Robinson CV, Smith BJ, Gulbis JM. A constricted opening in Kir channels does not impede potassium conduction. Nature Communications. 11: 3024. PMID 32541684 DOI: 10.1038/s41467-020-16842-0   
2020 Chow PH, Kourghi M, Pei JV, Nourmohammadi S, Yool AJ. 5-hydroxymethyl-furfural and structurally related compounds block the ion conductance in human aquaporin-1 channels, and slow cancer cell migration and invasion. Molecular Pharmacology. PMID 32434851 DOI: 10.1124/mol.119.119172   
2020 Cheung TP, Choe JY, Richmond JE, Kim H. BK channel density is regulated by endoplasmic reticulum associated degradation and influenced by the SKN-1A/NRF1 transcription factor. Plos Genetics. 16: e1008829. PMID 32502151 DOI: 10.1371/journal.pgen.1008829   
2020 Deng Z, Maksaev G, Rau M, Xie Z, Hu H, Fitzpatrick JAJ, Yuan P. Gating of human TRPV3 in a lipid bilayer. Nature Structural & Molecular Biology. PMID 32572252 DOI: 10.1038/s41594-020-0428-2   
2020 Yuen Chow C, Absalom N, Biggs K, King GF, Ma L. Venom-derived modulators of epilepsy-related ion channels. Biochemical Pharmacology. 114043. PMID 32445870 DOI: 10.1016/j.bcp.2020.114043   
2020 Zhang DM, Lin YF. Functional Modulation of Sarcolemmal K Channels by Atrial Natriuretic Peptide-Elicited Intracellular Signaling in Adult Rabbit Ventricular Cardiomyocytes. American Journal of Physiology. Cell Physiology. PMID 32432931 DOI: 10.1152/ajpcell.00409.2019   
2020 O'Connor B, Robbins N, Koch SE, Rubinstein J. TRPV2 channel-based therapies in the cardiovascular field. Molecular underpinnings of clinically relevant therapies. Progress in Biophysics and Molecular Biology. PMID 32565182 DOI: 10.1016/j.pbiomolbio.2020.06.001   
2020 Charlton AJ, Lian B, Blandin G, Leslie G, Le-Clech P. Impact of FO Operating Pressure and Membrane Tensile Strength on Draw-Channel Geometry and Resulting Hydrodynamics. Membranes. 10. PMID 32466224 DOI: 10.3390/membranes10050111   
2020 Van Theemsche KM, Van de Sande DV, Snyders DJ, Labro AJ. Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K and Na Channels. Frontiers in Pharmacology. 11: 735. PMID 32499709 DOI: 10.3389/fphar.2020.00735   
2020 Ortner NJ, Kaserer T, Copeland JN, Striessnig J. De novo CACAN1D Ca channelopathies: clinical phenotypes and molecular mechanism. Pflugers Archiv : European Journal of Physiology. PMID 32583268 DOI: 10.1007/s00424-020-02418-w   
2020 Stendel C, D'Adamo MC, Wiessner M, Dusl M, Cenciarini M, Belia S, Nematian-Ardestani E, Bauer P, Senderek J, Klopstock T, Pessia M. Association of A Novel Splice Site Mutation in P/Q-Type Calcium Channels with Childhood Epilepsy and Late-Onset Slowly Progressive Non-Episodic Cerebellar Ataxia. International Journal of Molecular Sciences. 21. PMID 32471306 DOI: 10.3390/ijms21113810   
2020 Rosenbaum T, Benítez-Angeles M, Sánchez-Hernández R, Morales-Lázaro SL, Hiriart M, Morales-Buenrostro LE, Torres-Quiroz F. TRPV4: A Physio and Pathophysiologically Significant Ion Channel. International Journal of Molecular Sciences. 21. PMID 32481620 DOI: 10.3390/ijms21113837   
2020 Yoder N, Gouaux E. The His-Gly motif of acid-sensing ion channels resides in a reentrant 'loop' implicated in gating and ion selectivity. Elife. 9. PMID 32496192 DOI: 10.7554/eLife.56527   
2020 Neumaier F, Alpdogan S, Hescheler J, Schneider T. Zn2+-induced changes in Cav2.3 channel function: An electrophysiological and modeling study. The Journal of General Physiology. 152. PMID 32559275 DOI: 10.1085/jgp.202012585   
2020 Rohaim A, Gong L, Li J, Rui H, Blachowicz L, Roux B. Open and closed structures of a barium-blocked potassium channel. Journal of Molecular Biology. PMID 32615129 DOI: 10.1016/j.jmb.2020.06.012   
2020 Quan XJ, Zou BC, Qin B, Dai F, Luo HS, Wang JH. [Effect of L-cysteine on colonic motility and the underlying mechanism]. Sheng Li Xue Bao : [Acta Physiologica Sinica]. 72: 299-307. PMID 32572428   
2020 Tiwari SK, Bhat S, Mahato KK. Design and Fabrication of Low-cost Microfluidic Channel for Biomedical Application. Scientific Reports. 10: 9215. PMID 32514070 DOI: 10.1038/s41598-020-65995-x   
2020 Akyüz E, Doğanyiğit Z, Paudel YN, Kaymak E, Yilmaz S, Uner A, Shaikh MF. Increased ACh-Associated Immunoreactivity in Autonomic Centers in PTZ Kindling Model of Epilepsy. Biomedicines. 8. PMID 32397136 DOI: 10.3390/biomedicines8050113   
2020 Cardoso FC. Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases. Biochemical Pharmacology. 114107. PMID 32579958 DOI: 10.1016/j.bcp.2020.114107   
2020 Thompson E, Eldstrom J, Fedida D. Hormonal Signaling Actions on Kv7.1 (KCNQ1) Channels. Annual Review of Pharmacology and Toxicology. PMID 32667860 DOI: 10.1146/annurev-pharmtox-010919-023645   
2020 Wang X, Jiang Z, Shen XH. Low Complexity Equalization of Orthogonal Chirp Division Multiplexing in Doubly-Selective Channels. Sensors (Basel, Switzerland). 20. PMID 32492855 DOI: 10.3390/s20113125   
2020 Brewer KR, Kuenze G, Vanoye CG, George AL, Meiler J, Sanders CR. Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome. Frontiers in Pharmacology. 11: 550. PMID 32431610 DOI: 10.3389/fphar.2020.00550   
2020 Loh KWZ, Liang MC, Soong TW, Hu Z. Regulation of cardiovascular calcium channel activity by post-translational modifications or interacting proteins. Pflugers Archiv : European Journal of Physiology. PMID 32435990 DOI: 10.1007/s00424-020-02398-x   
2020 Guet-McCreight A, Skinner FK. Computationally going where experiments cannot: a dynamical assessment of dendritic ion channel currents during -like states. F1000research. 9: 180. PMID 32595950 DOI: 10.12688/f1000research.22584.2