Dana W. Aswad - Publications

Affiliations: 
University of California, Irvine, Irvine, CA 
Area:
Protein chemistry, enzymology
Website:
http://www.faculty.uci.edu/scripts/UCIFacultyProfiles/detailMBB.cfm?ID=2135

83 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Qin Z, Zhu JX, Aswad DW. The D-isoAsp-25 variant of histone H2B is highly enriched in active chromatin: potential role in the regulation of gene expression? Amino Acids. PMID 26666674 DOI: 10.1007/s00726-015-2140-9  1
2015 Qin Z, Dimitrijevic A, Aswad DW. Accelerated protein damage in brains of PIMT+/- mice; a possible model for the variability of cognitive decline in human aging. Neurobiology of Aging. 36: 1029-36. PMID 25465735 DOI: 10.1016/j.neurobiolaging.2014.10.036  1
2014 Dimitrijevic A, Qin Z, Aswad DW. Isoaspartyl formation in creatine kinase B Is associated with loss of enzymatic activity; implications for the linkage of isoaspartate accumulation and neurological dysfunction in the PIMT knockout mouse. Plos One. 9: e100622. PMID 24955845 DOI: 10.1371/journal.pone.0100622  1
2014 Qin Z, Yang J, Klassen HJ, Aswad DW. Isoaspartyl protein damage and repair in mouse retina. Investigative Ophthalmology & Visual Science. 55: 1572-9. PMID 24550364 DOI: 10.1167/iovs.13-13668  1
2013 Qin Z, Kaufman RS, Khoury RN, Khoury MK, Aswad DW. Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent. Plos One. 8: e80758. PMID 24224061 DOI: 10.1371/journal.pone.0080758  1
2013 Doyle HA, Aswad DW, Mamula MJ. Autoimmunity to isomerized histone H2B in systemic lupus erythematosus. Autoimmunity. 46: 6-13. PMID 22967069 DOI: 10.3109/08916934.2012.710859  1
2012 Morrison GJ, Ganesan R, Qin Z, Aswad DW. Considerations in the identification of endogenous substrates for protein L-isoaspartyl methyltransferase: the case of synuclein. Plos One. 7: e43288. PMID 22905247 DOI: 10.1371/journal.pone.0043288  1
2010 Khoury MK, Parker I, Aswad DW. Acquisition of chemiluminescent signals from immunoblots with a digital single-lens reflex camera. Analytical Biochemistry. 397: 129-31. PMID 19788886 DOI: 10.1016/j.ab.2009.09.041  1
2008 Carter WG, Aswad DW. Formation, localization, and repair of L-isoaspartyl sites in histones H2A and H2B in nucleosomes from rat liver and chicken erythrocytes. Biochemistry. 47: 10757-64. PMID 18795804 DOI: 10.1021/bi8013467  1
2007 Zhu JX, Aswad DW. Selective cleavage of isoaspartyl peptide bonds by hydroxylamine after methyltransferase priming. Analytical Biochemistry. 364: 1-7. PMID 17376395 DOI: 10.1016/j.ab.2007.02.013  1
2007 Aswad DW. Protein L-isoaspartyl-O-methyltransferase catalyzes in Situ formation of D-aspartate and D-isoaspartate in proteins D-Amino Acids: a New Frontier in Amino Acid and Protein Research - Practical Methods and Protocols. 389-397.  1
2006 Yang ML, Doyle HA, Gee RJ, Lowenson JD, Clarke S, Lawson BR, Aswad DW, Mamula MJ. Intracellular protein modification associated with altered T cell functions in autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). 177: 4541-9. PMID 16982891  1
2006 Zhu JX, Doyle HA, Mamula MJ, Aswad DW. Protein repair in the brain, proteomic analysis of endogenous substrates for protein L-isoaspartyl methyltransferase in mouse brain. The Journal of Biological Chemistry. 281: 33802-13. PMID 16959769 DOI: 10.1074/jbc.M606958200  1
2006 Reissner KJ, Paranandi MV, Luc TM, Doyle HA, Mamula MJ, Lowenson JD, Aswad DW. Synapsin I is a major endogenous substrate for protein L-isoaspartyl methyltransferase in mammalian brain. The Journal of Biological Chemistry. 281: 8389-98. PMID 16443604 DOI: 10.1074/jbc.M510716200  1
2005 Young GW, Hoofring SA, Mamula MJ, Doyle HA, Bunick GJ, Hu Y, Aswad DW. Protein L-isoaspartyl methyltransferase catalyzes in vivo racemization of Aspartate-25 in mammalian histone H2B. The Journal of Biological Chemistry. 280: 26094-8. PMID 15908425 DOI: 10.1074/jbc.M503624200  1
2003 Reissner KJ, Aswad DW. Deamidation and isoaspartate formation in proteins: unwanted alterations or surreptitious signals? Cellular and Molecular Life Sciences : Cmls. 60: 1281-95. PMID 12943218 DOI: 10.1007/s00018-003-2287-5  1
2002 Li H, Park S, Kilburn B, Jelinek MA, Henschen-Edman A, Aswad DW, Stallcup MR, Laird-Offringa IA. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. The Journal of Biological Chemistry. 277: 44623-30. PMID 12237300 DOI: 10.1074/jbc.M206187200  1
2001 Ma H, Baumann CT, Li H, Strahl BD, Rice R, Jelinek MA, Aswad DW, Allis CD, Hager GL, Stallcup MR. Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter. Current Biology : Cb. 11: 1981-5. PMID 11747826 DOI: 10.1016/S0960-9822(01)00600-5  1
2001 Young AL, Carter WG, Doyle HA, Mamula MJ, Aswad DW. Structural integrity of histone H2B in vivo requires the activity of protein L-isoaspartate O-methyltransferase, a putative protein repair enzyme. The Journal of Biological Chemistry. 276: 37161-5. PMID 11479322 DOI: 10.1074/jbc.M106682200  1
2001 Schurter BT, Koh SS, Chen D, Bunick GJ, Harp JM, Hanson BL, Henschen-Edman A, Mackay DR, Stallcup MR, Aswad DW. Methylation of histone H3 by coactivator-associated arginine methyltransferase 1. Biochemistry. 40: 5747-56. PMID 11341840 DOI: 10.1021/bi002631b  1
2000 Stallcup MR, Chen D, Koh SS, Ma H, Lee YH, Li H, Schurter BT, Aswad DW. Co-operation between protein-acetylating and protein-methylating co-activators in transcriptional activation. Biochemical Society Transactions. 28: 415-8. PMID 10961931  1
2000 Schurter BT, Aswad DW. Analysis of isoaspartate in peptides and proteins without the use of radioisotopes. Analytical Biochemistry. 282: 227-31. PMID 10873277 DOI: 10.1006/abio.2000.4601  1
2000 Aswad DW, Paranandi MV, Schurter BT. Isoaspartate in peptides and proteins: formation, significance, and analysis. Journal of Pharmaceutical and Biomedical Analysis. 21: 1129-36. PMID 10708396 DOI: 10.1016/S0731-7085(99)00230-7  1
1999 David CL, Pierce VA, Aswad DW, Gibbs AG. The effect of urea exposure on isoaspartyl content and protein L-isoaspartate methyltransferase activity in Drosophila melanogaster. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 124: 423-7. PMID 10665370 DOI: 10.1016/S0305-0491(99)00135-2  1
1999 Chen D, Ma H, Hong H, Koh SS, Huang SM, Schurter BT, Aswad DW, Stallcup MR. Regulation of transcription by a protein methyltransferase. Science (New York, N.Y.). 284: 2174-7. PMID 10381882 DOI: 10.1126/science.284.5423.2174  1
1999 David CL, Keener J, Aswad DW. Isoaspartate in ribosomal protein S11 of Escherichia coli. Journal of Bacteriology. 181: 2872-7. PMID 10217780  1
1998 David CL, Orpiszewski J, Zhu XC, Reissner KJ, Aswad DW. Isoaspartate in chrondroitin sulfate proteoglycans of mammalian brain. The Journal of Biological Chemistry. 273: 32063-70. PMID 9822681 DOI: 10.1074/jbc.273.48.32063  1
1997 David CL, Szumlanski CL, DeVry CG, Park-Hah JO, Clarke S, Weinshilboum RM, Aswad DW. Human erythrocyte protein L-isoaspartyl methyltransferase: heritability of basal activity and genetic polymorphism for thermal stability. Archives of Biochemistry and Biophysics. 346: 277-86. PMID 9343375 DOI: 10.1006/abbi.1997.0303  1
1997 Aswad DW, Orpiszewski J, Zhu XC. Isoaspartate in chondroitin sulfate-rich proteoglycans of mammalian brain Faseb Journal. 11: A1095.  1
1997 David CL, Keener J, Aswad DW. Escherichia coli ribosomal protein 11 is a major substrate for protein l-isoaspartyl methyltransferase (PIMT) Faseb Journal. 11: A1274.  1
1996 Rich RC, Aswad DW. Characterization of the phosphorylation site of PP59, a substrate for cyclic AMP-dependent protein kinase that is enriched in the synaptic membrane fraction of rat cerebellum. Journal of Neurochemistry. 67: 2581-9. PMID 8931493  1
1996 Orpiszewski J, Aswad DW. High mass methyl-accepting protein (HMAP), a highly effective endogenous substrate for protein L-isoaspartyl methyltransferase in mammalian brain. The Journal of Biological Chemistry. 271: 22965-8. PMID 8798482 DOI: 10.1074/jbc.271.38.22965  1
1996 Najbauer J, Orpiszewski J, Aswad DW. Molecular aging of tubulin: accumulation of isoaspartyl sites in vitro and in vivo. Biochemistry. 35: 5183-90. PMID 8611502 DOI: 10.1021/bi953063g  1
1995 David CL, Aswad DW. Cloning, expression, and purification of rat brain protein L-isoaspartyl methyltransferase. Protein Expression and Purification. 6: 312-8. PMID 7663167 DOI: 10.1006/prep.1995.1041  1
1995 Paranandi MV, Aswad DW. Spontaneous alterations in the covalent structure of synapsin I during in vitro aging. Biochemical and Biophysical Research Communications. 212: 442-8. PMID 7626058 DOI: 10.1006/bbrc.1995.1989  1
1994 Paranandi MV, Guzzetta AW, Hancock WS, Aswad DW. Deamidation and isoaspartate formation during in vitro aging of recombinant tissue plasminogen activator. The Journal of Biological Chemistry. 269: 243-53. PMID 8276801  1
1994 Shahrokh Z, Eberlein G, Buckley D, Paranandi MV, Aswad DW, Stratton P, Mischak R, Wang YJ. Major degradation products of basic fibroblast growth factor: detection of succinimide and iso-aspartate in place of aspartate. Pharmaceutical Research. 11: 936-44. PMID 7937552 DOI: 10.1023/A:1018962732067  1
1993 Rich RC, Aswad DW. Identification of a 59-kDa Substrate for cAMP-Dependent Protein Kinase That Is Enriched in Rat Cerebellar Membranes. Molecular and Cellular Neurosciences. 4: 562-70. PMID 19912964 DOI: 10.1006/mcne.1993.1069  1
1993 Johnson BA, Aswad DW. Kinetic properties of bovine brain protein L-isoaspartyl methyltransferase determined using a synthetic isoaspartyl peptide substrate. Neurochemical Research. 18: 87-94. PMID 8464537 DOI: 10.1007/BF00966926  1
1993 Johnson BA, Najbauer J, Aswad DW. Accumulation of substrates for protein L-isoaspartyl methyltransferase in adenosine dialdehyde-treated PC12 cells. The Journal of Biological Chemistry. 268: 6174-81. PMID 8454593  1
1993 Potter SM, Henzel WJ, Aswad DW. In vitro aging of calmodulin generates isoaspartate at multiple Asn-Gly and Asp-Gly sites in calcium-binding domains II, III, and IV. Protein Science : a Publication of the Protein Society. 2: 1648-63. PMID 8251940 DOI: 10.1002/pro.5560021011  1
1993 Najbauer J, Johnson BA, Young AL, Aswad DW. Peptides with sequences similar to glycine, arginine-rich motifs in proteins interacting with RNA are efficiently recognized by methyltransferase(s) modifying arginine in numerous proteins. The Journal of Biological Chemistry. 268: 10501-9. PMID 7683681  1
1992 Najbauer J, Johnson BA, Aswad DW. Analysis of stable protein methylation in cultured cells. Archives of Biochemistry and Biophysics. 293: 85-92. PMID 1731643 DOI: 10.1016/0003-9861(92)90369-8  1
1992 Potter SM, Johnson BA, Henschen A, Aswad DW, Guzzetta AW. The type II isoform of bovine brain protein L-isoaspartyl methyltransferase has an endoplasmic reticulum retention signal (...RDEL) at its C-terminus. Biochemistry. 31: 6339-47. PMID 1627573  1
1991 Johnson BA, Shirokawa JM, Geddes JW, Choi BH, Kim RC, Aswad DW. Protein L-isoaspartyl methyltransferase in postmortem brains of aged humans. Neurobiology of Aging. 12: 19-24. PMID 2002878 DOI: 10.1016/0197-4580(91)90034-H  1
1991 Johnson BA, Aswad DW. Optimal conditions for the use of protein L-isoaspartyl methyltransferase in assessing the isoaspartate content of peptides and proteins. Analytical Biochemistry. 192: 384-91. PMID 1827964 DOI: 10.1016/0003-2697(91)90553-6  1
1991 Najbauer J, Johnson BA, Aswad DW. Amplification and detection of substrates for protein carboxyl methyltransferases in PC12 cells. Analytical Biochemistry. 197: 412-20. PMID 1785697 DOI: 10.1016/0003-2697(91)90413-N  1
1991 Johnson BA, Ngo SQ, Aswad DW. Widespread phylogenetic distribution of a protein methyltransferase that modifies L-isoaspartyl residues. Biochemistry International. 24: 841-7. PMID 1776952  1
1990 Najbauer J, Aswad DW. Diversity of methyl acceptor proteins in rat pheochromocytoma (PC12) cells revealed after treatment with adenosine dialdehyde. The Journal of Biological Chemistry. 265: 12717-21. PMID 2373708  1
1990 Aswad DW. Formation of isoaspartate in human growth hormone and bovine brain calmodulin. Annals of the New York Academy of Sciences. 613: 26-36. PMID 2150164  1
1990 Johnson BA, Aswad DW. Fragmentation of isoaspartyl peptides and proteins by carboxypeptidase Y: release of isoaspartyl dipeptides as a result of internal and external cleavage. Biochemistry. 29: 4373-80. PMID 2140948  1
1989 Johnson BA, Shirokawa JM, Aswad DW. Deamidation of calmodulin at neutral and alkaline pH: quantitative relationships between ammonia loss and the susceptibility of calmodulin to modification by protein carboxyl methyltransferase. Archives of Biochemistry and Biophysics. 268: 276-86. PMID 2912379 DOI: 10.1016/0003-9861(89)90589-4  1
1989 Henzel WJ, Stults JT, Hsu CA, Aswad DW. The primary structure of a protein carboxyl methyltransferase from bovine brain that selectively methylates L-isoaspartyl sites. The Journal of Biological Chemistry. 264: 15905-11. PMID 2777770  1
1989 Johnson BA, Shirokawa JM, Hancock WS, Spellman MW, Basa LJ, Aswad DW. Formation of isoaspartate at two distinct sites during in vitro aging of human growth hormone. The Journal of Biological Chemistry. 264: 14262-71. PMID 2760065  1
1989 O'Connor CM, Germain BJ, Guthrie KM, Aswad DW, Millette CF. Protein carboxyl methyltransferase activity specific for age-modified aspartyl residues in mouse testes and ovaries: evidence for translation during spermiogenesis. Gamete Research. 22: 307-19. PMID 2707731 DOI: 10.1002/mrd.1120220308  1
1989 Aswad DW. Protein carboxyl methylation in eukaryotes. Current Opinion in Cell Biology. 1: 1182-7. PMID 2699804 DOI: 10.1016/S0955-0674(89)80069-9  1
1988 Aswad DW, Johnson BA, Langmack EL, Shirokawa JM. Modification of isoaspartyl peptides and proteins by protein carboxyl methyltransferase from bovine brain. Advances in Experimental Medicine and Biology. 231: 247-59. PMID 3414433  1
1987 Johnson BA, Langmack EL, Aswad DW. Partial repair of deamidation-damaged calmodulin by protein carboxyl methyltransferase. The Journal of Biological Chemistry. 262: 12283-7. PMID 3624258  1
1987 Johnson BA, Murray ED, Clarke S, Glass DB, Aswad DW. Protein carboxyl methyltransferase facilitates conversion of atypical L-isoaspartyl peptides to normal L-aspartyl peptides. The Journal of Biological Chemistry. 262: 5622-9. PMID 3571226  1
1987 Aswad DW, Johnson BA, Glass DB. Modification of synthetic peptides related to lactate dehydrogenase (231-242) by protein carboxyl methyltransferase and tyrosine protein kinase: effects of introducing an isopeptide bond between aspartic acid-235 and serine-236. Biochemistry. 26: 675-81. PMID 3105574  1
1987 Aswad DW, Johnson BA. The unusual substrate specificity of eukaryotic protein carboxyl methyltransferases Trends in Biochemical Sciences. 12: 155-158. DOI: 10.1016/0968-0004(87)90073-9  1
1985 Johnson BA, Aswad DW. Identification and topography of substrates for protein carboxyl methyltransferase in synaptic membrane and myelin-enriched fractions of bovine and rat brain. Journal of Neurochemistry. 45: 1119-27. PMID 4031881  1
1985 Johnson BA, Freitag NE, Aswad DW. Protein carboxyl methyltransferase selectively modifies an atypical form of calmodulin. Evidence for methylation at deamidated asparagine residues. The Journal of Biological Chemistry. 260: 10913-6. PMID 4030774  1
1985 Johnson BA, Aswad DW. Enzymatic protein carboxyl methylation at physiological pH: cyclic imide formation explains rapid methyl turnover. Biochemistry. 24: 2581-6. PMID 4016073  1
1984 Aswad DW. Determination of D- and L-aspartate in amino acid mixtures by high-performance liquid chromatography after derivatization with a chiral adduct of o-phthaldialdehyde. Analytical Biochemistry. 137: 405-9. PMID 6731824 DOI: 10.1016/0003-2697(84)90106-4  1
1984 O'Connor CM, Aswad DW, Clarke S. Mammalian brain and erythrocyte carboxyl methyltransferases are similar enzymes that recognize both D-aspartyl and L-isoaspartyl residues in structurally altered protein substrates. Proceedings of the National Academy of Sciences of the United States of America. 81: 7757-61. PMID 6595658  1
1984 Hemmings HC, Nairn AC, Aswad DW, Greengard P. DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Purification and characterization of the phosphoprotein from bovine caudate nucleus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 4: 99-110. PMID 6319628  1
1984 Detre JA, Nairn AC, Aswad DW, Greengard P. Localization in mammalian brain of G-substrate, a specific substrate for guanosine 3',5'-cyclic monophosphate-dependent protein kinase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 4: 2843-9. PMID 6094745  1
1984 Aswad DW. Stoichiometric methylation of porcine adrenocorticotropin by protein carboxyl methyltransferase requires deamidation of asparagine 25. Evidence for methylation at the alpha-carboxyl group of atypical L-isoaspartyl residues. The Journal of Biological Chemistry. 259: 10714-21. PMID 6088513  1
1984 Aswad DW. cGMP-dependent protein phosphorylation in the nervous system Trends in Pharmacological Sciences. 5: 64-66. DOI: 10.1016/0165-6147(84)90369-9  1
1983 Aswad DW, Deight EA. Purification and characterization of two distinct isozymes of protein carboxymethylase from bovine brain. Journal of Neurochemistry. 40: 1718-26. PMID 6854329  1
1983 Aswad DW, Deight EA. Endogenous substrates for protein carboxyl methyltransferase in cytosolic fractions of bovine brain. Journal of Neurochemistry. 41: 1702-9. PMID 6644307  1
1983 Walaas SI, Aswad DW, Greengard P. A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. Nature. 301: 69-71. PMID 6296685 DOI: 10.1038/301069a0  1
1981 Aitken A, Bilham T, Cohen P, Aswad D, Greengard P. A specific substrate from rabbit cerebellum for guanosine-3':5'-monophosphate-dependent protein kinase. III. Amino acid sequences at the two phosphorylation sites Journal of Biological Chemistry. 256: 3501-3506. PMID 6259172  1
1981 Aswad DW, Greengard P. A specific substrate from rabbit cerebellum for guanosine 3':5'-monophosphate-dependent protein kinase. II. Kinetic studies on its phosphorylation by guanosine 3':5'-monophosphate-dependent and adenosine 3':5'-monophosphate-dependent protein kinases. The Journal of Biological Chemistry. 256: 3494-500. PMID 6259171  1
1981 Aswad DW, Greengard P. A specific substrate from rabbit cerebellum for guanosine 3':5'-monophosphate-dependent protein kinase. I. Purification and characterization. The Journal of Biological Chemistry. 256: 3487-93. PMID 6259170  1
1980 Schlichter DJ, Detre JA, Aswad DW, Chehrazi B, Greengard P. Localization of cyclic GMP-dependent protein kinase and substrate in mammalian cerebellum. Proceedings of the National Academy of Sciences of the United States of America. 77: 5537-41. PMID 6254089  1
1978 Aswad DW. Biosynthesis and processing of presumed neurosecretory proteins in single identified neurons of Aplysia californica. Journal of Neurobiology. 9: 267-84. PMID 28379 DOI: 10.1002/neu.480090404  1
1977 Aswad DW. Heterogeneity and processing of low molecular weight protein in cell R15 of Aplysia californica. Journal of Neurochemistry. 28: 1137-40. PMID 864463  1
1975 Aswad D, Koshland DE. Isolation, characterization and complementation of Salmonella typhimurium chemotaxis mutants Journal of Molecular Biology. 97: 225-235. PMID 1100857 DOI: 10.1016/S0022-2836(75)80036-2  1
1975 Aswad DW, Koshland DE. Evidence for an S-adenosylmethionine requirement in the chemotactic behavior of Salmonella typhimurium. Journal of Molecular Biology. 97: 207-23. PMID 1100856 DOI: 10.1016/S0022-2836(75)80035-0  1
1974 Aswad D, Koshland DE. Role of methionine in bacterial chemotaxis Journal of Bacteriology. 118: 640-645. PMID 4597455  1
1973 Aswad D, Koshland DE. The role of methionine in bacterial chemotaxis Federation Proceedings. 32: 2159.  1
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