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Binu Tharakan - Publications

Affiliations: 
2012-2019 Surgery Texas A&M University College of Medicine and & Baylor Scott and White Research Institute 
 2019- Surgery Morehouse School of Medicine, Atlanta, GA, United States 
Area:
Blood-brain barrier, microvascular permeability, traumatic brain injury
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61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Sunny A, James RR, Menon SR, Rayaroth S, Daniel A, Thompson NA, Tharakan B. Matrix Metalloproteinase-9 inhibitors as therapeutic drugs for traumatic brain injury. Neurochemistry International. 105642. PMID 38008261 DOI: 10.1016/j.neuint.2023.105642  0.492
2023 Alluri H, Peddaboina CS, Tharakan B. Evaluation of Tight Junction Integrity in Brain Endothelial Cells Using Confocal Microscopy. Methods in Molecular Biology (Clifton, N.J.). 2711: 257-262. PMID 37776464 DOI: 10.1007/978-1-0716-3429-5_21  0.809
2023 Alluri H, Peddaboina CS, Tharakan B. Determination of Tight Junction Integrity in Brain Endothelial Cells Based on Tight Junction Protein Expression. Methods in Molecular Biology (Clifton, N.J.). 2711: 235-240. PMID 37776462 DOI: 10.1007/978-1-0716-3429-5_19  0.804
2023 Waithe OY, Peng X, Childs EW, Tharakan B. Measurement of Transendothelial Electrical Resistance in Blood-Brain Barrier Endothelial Cells. Methods in Molecular Biology (Clifton, N.J.). 2711: 199-203. PMID 37776459 DOI: 10.1007/978-1-0716-3429-5_16  0.82
2023 Waithe OY, Peng X, Childs EW, Tharakan B. Measurement of Blood-Brain Barrier Hyperpermeability Using Evans Blue Extravasation Assay. Methods in Molecular Biology (Clifton, N.J.). 2711: 177-184. PMID 37776457 DOI: 10.1007/978-1-0716-3429-5_14  0.826
2023 Waithe OY, Shaji CA, Childs EW, Tharakan B. Determination of Blood-Brain Barrier Hyperpermeability Using Intravital Microscopy. Methods in Molecular Biology (Clifton, N.J.). 2711: 117-127. PMID 37776453 DOI: 10.1007/978-1-0716-3429-5_10  0.803
2022 Robinson BD, Isbell CL, Melge AR, Lomas AM, Shaji CA, Mohan CG, Huang JH, Tharakan B. Doxycycline prevents blood-brain barrier dysfunction and microvascular hyperpermeability after traumatic brain injury. Scientific Reports. 12: 5415. PMID 35354869 DOI: 10.1038/s41598-022-09394-4  0.855
2021 Tharakan B, Hunter FA, Muthusamy S, Randolph S, Byrd C, Rao VN, Reddy ESP, Childs EW. ETS-Related Gene Activation Preserves Adherens Junctions and Permeability in Microvascular Endothelial Cells. Shock (Augusta, Ga.). PMID 34907119 DOI: 10.1097/SHK.0000000000001899  0.358
2021 Tharakan B, Hunter FA, Childs EW. Protective Effects of FK 506 Against Hemorrhagic Shock-Induced Microvascular Hyperpermeability. Clinical and Experimental Pharmacology & Physiology. PMID 34432902 DOI: 10.1111/1440-1681.13578  0.31
2021 Huang C, Wu L, Wang J, Tharakan B, Peng X. Detecting Three-Dimensional Vascular Networks in the Mouse Embryonic Hindbrain. Methods in Molecular Biology (Clifton, N.J.). 2319: 87-92. PMID 34331246 DOI: 10.1007/978-1-0716-1480-8_10  0.389
2020 Malek AJ, Robinson BD, Hitt AR, Shaver CN, Tharakan B, Isbell CL. Doxycycline improves traumatic brain injury outcomes in a murine survival model. The Journal of Trauma and Acute Care Surgery. PMID 32467458 DOI: 10.1097/TA.0000000000002801  0.732
2020 Robinson BD, Tharakan B, Lomas A, Wiggins-Dohlvik K, Alluri H, Shaji CA, Jupiter D, Isbell CL. Exploring blood-brain barrier hyperpermeability and potential biomarkers in traumatic brain injury. Proceedings (Baylor University. Medical Center). 33: 199-204. PMID 32313461 DOI: 10.1080/08998280.2020.1727706  0.797
2020 Peng J, Lambertis A, Hunter F, Childs E, Tharakan B. Cathepsin‐B is a Mediator of Barrier Dysfunction and Hyperpermeability in Blood‐Brain Barrier Endothelial Cells The Faseb Journal. 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.06905  0.321
2019 Anasooya Shaji C, Robinson BD, Yeager A, Beeram MR, Davis ML, Isbell CL, Huang JH, Tharakan B. The Tri-phasic Role of Hydrogen Peroxide in Blood-Brain Barrier Endothelial cells. Scientific Reports. 9: 133. PMID 30644421 DOI: 10.1038/S41598-018-36769-3  0.719
2018 Robinson BD, Isbell CL, Shaji CA, Kurek S, Regner JL, Tharakan B. QUETIAPINE PROTECTS THE BLOOD-BRAIN BARRIER IN TRAUMATIC BRAIN INJURY. The Journal of Trauma and Acute Care Surgery. PMID 29985239 DOI: 10.1097/Ta.0000000000002011  0.831
2018 Robinson BD, Shaji CA, Lomas A, Tharakan B. Measurement of Microvascular Endothelial Barrier Dysfunction and Hyperpermeability In Vitro. Methods in Molecular Biology (Clifton, N.J.). 1717: 237-242. PMID 29468597 DOI: 10.1007/978-1-4939-7526-6_19  0.811
2018 Wiggins-Dohlvik K, Tharakan B. A Rat Burn Injury Model for Studying Changes in Microvascular Permeability. Methods in Molecular Biology (Clifton, N.J.). 1717: 93-100. PMID 29468586 DOI: 10.1007/978-1-4939-7526-6_8  0.78
2018 Alluri H, Shaji CA, Davis ML, Tharakan B. A Mouse Controlled Cortical Impact Model of Traumatic Brain Injury for Studying Blood-Brain Barrier Dysfunctions. Methods in Molecular Biology (Clifton, N.J.). 1717: 37-52. PMID 29468582 DOI: 10.1007/978-1-4939-7526-6_4  0.817
2018 Cromer WE, Zawieja SD, Doersch KM, Stagg H, Hunter F, Tharakan B, Childs E, Zawieja DC. Burn Injury-Associated MHCII+ Immune Cell Accumulation Around Lymphatic Vessels of the Mesentery and Increased Lymphatic Endothelial Permeability Are Blocked by Doxycycline Treatment. Lymphatic Research and Biology. PMID 29359999 DOI: 10.1089/lrb.2017.0032  0.407
2016 Alluri H, Grimsley M, Anasooya Shaji C, Varghese KP, Zhang SL, Peddaboina C, Robinson B, Beeram MR, Huang JH, Tharakan B. Attenuation of Blood-Brain Barrier Breakdown and Hyperpermeability by Calpain Inhibition. The Journal of Biological Chemistry. PMID 27875293 DOI: 10.1074/Jbc.M116.735365  0.818
2016 Alluri H, Wilson RL, Anasooya Shaji C, Wiggins-Dohlvik K, Patel S, Liu Y, Peng X, Beeram MR, Davis ML, Huang JH, Tharakan B. Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition. Plos One. 11: e0154427. PMID 27152411 DOI: 10.1371/Journal.Pone.0154427  0.835
2015 Tharakan B, McNeal SI, Hunter FA, Sawant DA, Smythe WR, Childs EW. RECOMBINANT BCL-XL ATTENUATES VASCULAR HYPERPERMEABILITY IN A RAT MODEL OF HEMORRHAGIC SHOCK. Cell Death Discovery. 1. PMID 27042339 DOI: 10.1038/cddiscovery.2015.42  0.413
2015 Wiggins-Dohlvik K, Stagg HW, Han MS, Alluri H, Oakley RP, Shaji CA, Davis ML, Tharakan B. Doxycycline Attenuates Lipopolysaccharide-Induced Microvascular Endothelial Cell Derangements. Shock (Augusta, Ga.). PMID 26717103 DOI: 10.1097/Shk.0000000000000556  0.772
2015 Wiggins-Dohlvik K, Oakley RP, Han MS, Stagg HW, Alluri H, Shaji CA, Davis ML, Tharakan B. Tissue inhibitor of metalloproteinase-2 inhibits burn-induced derangements and hyperpermeability in microvascular endothelial cells. American Journal of Surgery. PMID 26601648 DOI: 10.1016/J.Amjsurg.2015.08.016  0.761
2015 Sawant DA, Tharakan B, Hunter FA, Childs EW. Glycogen synthase kinase 3 inhibitor protects against microvascular hyperpermeability following hemorrhagic shock. The Journal of Trauma and Acute Care Surgery. 79: 609-16. PMID 26402535 DOI: 10.1097/TA.0000000000000807  0.365
2015 Alluri H, Anasooya Shaji C, Davis ML, Tharakan B. Oxygen-glucose deprivation and reoxygenation as an in vitro ischemia-reperfusion injury model for studying blood-brain barrier dysfunction. Journal of Visualized Experiments : Jove. e52699. PMID 25992584 DOI: 10.3791/52699  0.826
2015 Alluri H, Wiggins-Dohlvik K, Davis ML, Huang JH, Tharakan B. Blood-brain barrier dysfunction following traumatic brain injury. Metabolic Brain Disease. PMID 25624154 DOI: 10.1007/S11011-015-9651-7  0.83
2014 Sawant DA, Wilson RL, Tharakan B, Stagg HW, Hunter FA, Childs EW. Tumor necrosis factor-α-induced microvascular endothelial cell hyperpermeability: role of intrinsic apoptotic signaling. Journal of Physiology and Biochemistry. 70: 971-80. PMID 25392259 DOI: 10.1007/s13105-014-0366-8  0.35
2014 Wiggins-Dohlvik K, Merriman M, Shaji CA, Alluri H, Grimsley M, Davis ML, Smith RW, Tharakan B. Tumor necrosis factor-α disruption of brain endothelial cell barrier is mediated through matrix metalloproteinase-9. American Journal of Surgery. 208: 954-60; discussion 9. PMID 25312844 DOI: 10.1016/J.Amjsurg.2014.08.014  0.799
2014 Sawant DA, Tharakan B, Hunter FA, Childs EW. The role of intrinsic apoptotic signaling in hemorrhagic shock-induced microvascular endothelial cell barrier dysfunction. Journal of Cardiovascular Translational Research. 7: 711-8. PMID 25277298 DOI: 10.1007/s12265-014-9589-x  0.426
2014 Wiggins-Dohlvik K, Han MS, Stagg HW, Alluri H, Shaji CA, Oakley RP, Davis ML, Tharakan B. Melatonin inhibits thermal injury-induced hyperpermeability in microvascular endothelial cells. The Journal of Trauma and Acute Care Surgery. 77: 899-905; discussion . PMID 25051382 DOI: 10.1097/Ta.0000000000000346  0.784
2014 Oakley R, Tharakan B. Vascular hyperpermeability and aging. Aging and Disease. 5: 114-25. PMID 24729937 DOI: 10.14336/Ad.2014.0500114  0.678
2014 Alluri H, Stagg HW, Wilson RL, Clayton RP, Sawant DA, Koneru M, Beeram MR, Davis ML, Tharakan B. Reactive oxygen species-caspase-3 relationship in mediating blood-brain barrier endothelial cell hyperpermeability following oxygen-glucose deprivation and reoxygenation. Microcirculation (New York, N.Y. : 1994). 21: 187-95. PMID 24372803 DOI: 10.1111/Micc.12110  0.826
2014 Cromer WE, Zawieja SD, Tharakan B, Childs EW, Newell MK, Zawieja DC. The effects of inflammatory cytokines on lymphatic endothelial barrier function. Angiogenesis. 17: 395-406. PMID 24141404 DOI: 10.1007/s10456-013-9393-2  0.399
2014 Wiggins-Dohlvik K, Alluir H, Shaji CA, Govande V, Beeram M, Mohammad A, Davis M, Tharakan B. 6 Critical Care Medicine. 42: A1370. DOI: 10.1097/01.Ccm.0000457539.24608.D8  0.747
2014 Wiggins-Dohlvik KC, Stagg HW, Shaji CA, Oakley RP, Alluri H, Mukhopadhyay D, Perger L, Davis ML, Tharakan B. Tissue Inhibitor of Metalloproteinases-2 (TIMP2) Inhibits Hemorrhagic Shock (HS)-Induced Vascular Hyperpermeability Journal of the American College of Surgeons. 219: S40. DOI: 10.1016/J.Jamcollsurg.2014.07.088  0.755
2013 Stagg HW, Whaley JG, Tharakan B, Hunter FA, Jupiter D, Little DC, Davis ML, Smythe WR, Childs EW. Doxycycline attenuates burn-induced microvascular hyperpermeability. The Journal of Trauma and Acute Care Surgery. 75: 1040-6; discussion 1. PMID 24256679 DOI: 10.1097/TA.0b013e3182aa9c79  0.476
2013 Sawant DA, Tharakan B, Wilson RL, Stagg HW, Hunter FA, Childs EW. Regulation of tumor necrosis factor-α-induced microvascular endothelial cell hyperpermeability by recombinant B-cell lymphoma-extra large. The Journal of Surgical Research. 184: 628-37. PMID 23731686 DOI: 10.1016/j.jss.2013.04.079  0.429
2013 Stagg HW, Bowen KA, Sawant DA, Rodriguez M, Tharakan B, Childs EW. Tumor necrosis factor-related apoptosis-inducing ligand promotes microvascular endothelial cell hyperpermeability through phosphatidylinositol 3-kinase pathway. American Journal of Surgery. 205: 419-25. PMID 23375756 DOI: 10.1016/j.amjsurg.2012.10.027  0.345
2013 Sawant DA, Tharakan B, Tobin RP, Reilly J, Hunter FA, Newell MK, Smythe WR, Childs EW. Microvascular endothelial cell hyperpermeability induced by endogenous caspase 3 activator staurosporine. The Journal of Trauma and Acute Care Surgery. 74: 516-23. PMID 23354245 DOI: 10.1097/TA.0b013e31827a0620  0.405
2013 Sawant DA, Tharakan B, Tobin RP, Stagg HW, Hunter FA, Newell MK, Smythe WR, Childs EW. Inhibition of Fas-Fas ligand interaction attenuates microvascular hyperpermeability following hemorrhagic shock. Shock (Augusta, Ga.). 39: 161-7. PMID 23324886 DOI: 10.1097/SHK.0b013e31827bba73  0.39
2013 Sawant DA, Tharakan B, Hunter FA, Childs EW. Recombinant Bcl-xL Protein Attenuates TNF-alpha Induced Microvascular Endothelial Cell Hyperpermeability Journal of Surgical Research. 179: 331. DOI: 10.1016/J.Jss.2012.10.674  0.334
2012 Tharakan B, Hellman J, Sawant DA, Tinsley JH, Parrish AR, Hunter FA, Smythe WR, Childs EW. β-Catenin dynamics in the regulation of microvascular endothelial cell hyperpermeability. Shock (Augusta, Ga.). 37: 306-11. PMID 22089197 DOI: 10.1097/SHK.0b013e318240b564  0.372
2012 Janicek A, Tharakan B, Sawant DA, Hunter FA, Childs EW. Lipopolysaccharide-Induced Endothelial Cell Hyperpermeability: Role of Mitochondrial Apoptotic Signaling Pathway Journal of Surgical Research. 172: 330. DOI: 10.1016/J.Jss.2011.11.602  0.33
2011 Sawant DA, Tharakan B, Hunter FA, Smythe WR, Childs EW. Role of β-catenin in regulating microvascular endothelial cell hyperpermeability. The Journal of Trauma. 70: 481-7; discussion 48. PMID 21307750 DOI: 10.1097/TA.0b013e31820b3ed7  0.393
2011 Sawant DA, Tharakan B, Adekanbi A, Hunter FA, Smythe WR, Childs EW. Inhibition of VE-cadherin proteasomal degradation attenuates microvascular hyperpermeability. Microcirculation (New York, N.Y. : 1994). 18: 46-55. PMID 21166925 DOI: 10.1111/j.1549-8719.2010.00067.x  0.398
2011 McKenzie JR, Tharakan B, Sawant DA, Whaley JG, Hunter FA, Childs EW. Staurosporine Induces Brain Microvascular Endothelial Cell Hyperpermeability Through Intrinsic Apoptotic Signaling Pathway Journal of Surgical Research. 165: 183. DOI: 10.1016/J.Jss.2010.11.672  0.461
2011 Sawant DA, Tharakan B, Whaley JG, Hunter FA, Childs EW. β-Catenin Cleavage And Microvascular Endothelial Cell Hyperpermeability Induced By Staurosporine Journal of Surgical Research. 165: 343. DOI: 10.1016/J.Jss.2010.11.078  0.337
2010 Tharakan B, Hunter FA, Smythe WR, Childs EW. Curcumin inhibits reactive oxygen species formation and vascular hyperpermeability following haemorrhagic shock. Clinical and Experimental Pharmacology & Physiology. 37: 939-44. PMID 20528978 DOI: 10.1111/j.1440-1681.2010.05414.x  0.391
2010 Childs EW, Tharakan B, Nurudeen S, Delmas TL, Hellman J, Christie T, Hunter FA, Smythe WR. Cyclosporine A--protection against microvascular hyperpermeability is calcineurin independent. American Journal of Surgery. 199: 542-8. PMID 20359571 DOI: 10.1016/j.amjsurg.2009.11.002  0.323
2009 Whaley JG, Tharakan B, Smith B, Hunter FA, Childs EW. (-)-Deprenyl inhibits thermal injury-induced apoptotic signaling and hyperpermeability in microvascular endothelial cells. Journal of Burn Care & Research : Official Publication of the American Burn Association. 30: 1018-27. PMID 19826263 DOI: 10.1097/BCR.0b013e3181bfb825  0.396
2009 Tharakan B, Holder-Haynes JG, Hunter FA, Smythe WR, Childs EW. Cyclosporine A prevents vascular hyperpermeability after hemorrhagic shock by inhibiting apoptotic signaling. The Journal of Trauma. 66: 1033-9. PMID 19359911 DOI: 10.1097/TA.0b013e31816c905f  0.359
2009 Uddin MN, McLean LB, Hunter FA, Horvat D, Severson J, Tharakan B, Childs EW, Puschett JB. Vascular leak in a rat model of preeclampsia. American Journal of Nephrology. 30: 26-33. PMID 19194101 DOI: 10.1159/000193220  0.304
2009 Tharakan B, Corprew R, Hunter FA, Whaley JG, Smythe WR, Childs EW. 17beta-estradiol mediates protection against microvascular endothelial cell hyperpermeability. American Journal of Surgery. 197: 147-54. PMID 19185107 DOI: 10.1016/j.amjsurg.2008.10.003  0.332
2009 Childs EW, Tharakan B, Hunter FA. QS408. Apoptotic Signaling Regulates Vascular Hyperpermeability Following Hemorrhagic Shock Journal of Surgical Research. 151: 301. DOI: 10.1016/J.Jss.2008.11.719  0.324
2008 Tharakan B, Hunter FA, Smythe WR, Childs EW. Alpha-lipoic acid attenuates hemorrhagic shock-induced apoptotic signaling and vascular hyperpermeability. Shock (Augusta, Ga.). 30: 571-7. PMID 18923301 DOI: 10.1097/SHK.0b013e31816a7308  0.34
2008 Childs EW, Tharakan B, Hunter FA, Isong M, Liggins ND. Mitochondrial complex III is involved in proapoptotic BAK-induced microvascular endothelial cell hyperpermeability. Shock (Augusta, Ga.). 29: 636-41. PMID 18414238 DOI: 10.1097/SHK.0b013e318157f524  0.356
2008 Childs EW, Tharakan B, Byrge N, Tinsley JH, Hunter FA, Smythe WR. Angiopoietin-1 inhibits intrinsic apoptotic signaling and vascular hyperpermeability following hemorrhagic shock. American Journal of Physiology. Heart and Circulatory Physiology. 294: H2285-95. PMID 18344375 DOI: 10.1152/ajpheart.01361.2007  0.38
2008 Tharakan B, Holder-Haynes JG, Hunter FA, Childs EW. Alpha lipoic acid attenuates microvascular endothelial cell hyperpermeability by inhibiting the intrinsic apoptotic signaling. American Journal of Surgery. 195: 174-8. PMID 18096126 DOI: 10.1016/j.amjsurg.2007.09.028  0.361
2007 Dhanasekaran M, Tharakan B, Holcomb LA, Hitt AR, Young KA, Manyam BV. Neuroprotective mechanisms of ayurvedic antidementia botanical Bacopa monniera. Phytotherapy Research : Ptr. 21: 965-9. PMID 17604373 DOI: 10.1002/ptr.2195  0.306
2007 Childs EW, Tharakan B, Hunter FA, Tinsley JH, Cao X. Apoptotic signaling induces hyperpermeability following hemorrhagic shock. American Journal of Physiology. Heart and Circulatory Physiology. 292: H3179-89. PMID 17307990 DOI: 10.1152/ajpheart.01337.2006  0.333
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