Daniel Coombs, Ph.D. - Publications

Affiliations: 
2001 University of Arizona, Tucson, AZ 
Area:
biological physics

37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Cardim Falcao R, Coombs D. Diffusion analysis of single particle trajectories in a Bayesian nonparametrics framework. Physical Biology. PMID 31860874 DOI: 10.1088/1478-3975/Ab64B3  0.313
2019 Bolger-Munro M, Choi K, Scurll JM, Abraham L, Chappell RS, Sheen D, Dang-Lawson M, Wu X, Priatel JJ, Coombs D, Hammer JA, Gold MR. Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and cell activation. Elife. 8. PMID 31157616 DOI: 10.7554/Elife.44574  0.378
2018 Azoz SA, Coombs D. Stochastic Dynamics of the Latently Infected Cell Reservoir During HIV Infection. Bulletin of Mathematical Biology. PMID 30298198 DOI: 10.1007/S11538-018-0520-5  0.312
2017 Abraham L, Lu HY, Falcão RC, Scurll J, Jou T, Irwin B, Tafteh R, Gold MR, Coombs D. Limitations of Qdot labelling compared to directly-conjugated probes for single particle tracking of B cell receptor mobility. Scientific Reports. 7: 11379. PMID 28900238 DOI: 10.1038/S41598-017-11563-9  0.355
2016 López-Ceballos P, Herrera-Reyes AD, Coombs D, Tanentzapf G. In vivo regulation of integrin turnover by outside-in activation. Journal of Cell Science. PMID 27311483 DOI: 10.1242/Dev.143081  0.311
2015 Hákonardóttir GK, López-Ceballos P, Herrera-Reyes AD, Das R, Coombs D, Tanentzapf G. In Vivo Quantitative Analysis of Talin turnover in response to force. Molecular Biology of the Cell. PMID 26446844 DOI: 10.1091/Mbc.E15-05-0304  0.311
2015 Woodsworth DJ, Dunsing V, Coombs D. Design Parameters for Granzyme-Mediated Cytotoxic Lymphocyte Target-Cell Killing and Specificity. Biophysical Journal. 109: 477-88. PMID 26244730 DOI: 10.1016/J.Bpj.2015.06.045  0.353
2015 Freeman SA, Jaumouillé V, Choi K, Hsu BE, Wong HS, Abraham L, Graves ML, Coombs D, Roskelley CD, Das R, Grinstein S, Gold MR. Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor. Nature Communications. 6: 6168. PMID 25644899 DOI: 10.1038/Ncomms7168  0.374
2015 Delgado MI, Ward MJ, Coombs D. Conditional mean first passage times to small traps in a 3-D domain with a sticky boundary: Applications to T cell searching behavior in lymph nodes Multiscale Modeling and Simulation. 13: 1224-1258. DOI: 10.1137/140978314  0.32
2012 Allard JF, Dushek O, Coombs D, van der Merwe PA. Mechanical modulation of receptor-ligand interactions at cell-cell interfaces. Biophysical Journal. 102: 1265-73. PMID 22455909 DOI: 10.1016/J.Bpj.2012.02.006  0.664
2011 Dushek O, Aleksic M, Wheeler RJ, Zhang H, Cordoba SP, Peng YC, Chen JL, Cerundolo V, Dong T, Coombs D, van der Merwe PA. Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation. Science Signaling. 4: ra39. PMID 21653229 DOI: 10.1126/Scisignal.2001430  0.693
2011 Gutenkunst RN, Coombs D, Starr T, Dustin ML, Goldstein B. A biophysical model of cell adhesion mediated by immunoadhesin drugs and antibodies. Plos One. 6: e19701. PMID 21629715 DOI: 10.1371/Journal.Pone.0019701  0.419
2011 Conway JM, Coombs D. A stochastic model of latently infected cell reactivation and viral blip generation in treated HIV patients. Plos Computational Biology. 7: e1002033. PMID 21552334 DOI: 10.1371/Journal.Pcbi.1002033  0.305
2010 Valitutti S, Coombs D, Dupré L. The space and time frames of T cell activation at the immunological synapse. Febs Letters. 584: 4851-7. PMID 20940018 DOI: 10.1016/J.Febslet.2010.10.010  0.434
2010 Cairo CW, Das R, Albohy A, Baca QJ, Pradhan D, Morrow JS, Coombs D, Golan DE. Dynamic regulation of CD45 lateral mobility by the spectrin-ankyrin cytoskeleton of T cells. The Journal of Biological Chemistry. 285: 11392-401. PMID 20164196 DOI: 10.1074/Jbc.M109.075648  0.364
2010 Aleksic M, Dushek O, Zhang H, Shenderov E, Chen JL, Cerundolo V, Coombs D, van der Merwe PA. Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time. Immunity. 32: 163-74. PMID 20137987 DOI: 10.1016/J.Immuni.2009.11.013  0.684
2009 Dushek O, Das R, Coombs D. A role for rebinding in rapid and reliable T cell responses to antigen. Plos Computational Biology. 5: e1000578. PMID 19956745 DOI: 10.1371/Journal.Pcbi.1000578  0.695
2009 Das R, Cairo CW, Coombs D. A hidden Markov model for single particle tracks quantifies dynamic interactions between LFA-1 and the actin cytoskeleton. Plos Computational Biology. 5: e1000556. PMID 19893741 DOI: 10.1371/Journal.Pcbi.1000556  0.343
2009 Coombs D, Straube R, Ward M. Diffusion on a Sphere with Localized Traps: Mean First Passage Time, Eigenvalue Asymptotics, and Fekete Points Siam Journal On Applied Mathematics. 70: 302-332. DOI: 10.1137/080733280  0.315
2008 Dushek O, Mueller S, Soubies S, Depoil D, Caramalho I, Coombs D, Valitutti S. Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery. Plos One. 3: e3913. PMID 19079546 DOI: 10.1371/Journal.Pone.0003913  0.667
2008 Goldstein B, Coombs D, Faeder JR, Hlavacek WS. Kinetic proofreading model. Advances in Experimental Medicine and Biology. 640: 82-94. PMID 19065786 DOI: 10.1007/978-0-387-09789-3_8  0.392
2008 Dushek O, Das R, Coombs D. Analysis of membrane-localized binding kinetics with FRAP. European Biophysics Journal : Ebj. 37: 627-38. PMID 18299825 DOI: 10.1007/S00249-008-0286-Z  0.633
2008 Dushek O, Coombs D. Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters. Biophysical Journal. 94: 3447-60. PMID 18227132 DOI: 10.1529/Biophysj.107.116897  0.671
2008 Dushek O, Coombs D. Improving parameter estimation for cell surface FRAP data. Journal of Biochemical and Biophysical Methods. 70: 1224-31. PMID 17707082 DOI: 10.1016/J.Jbbm.2007.07.002  0.637
2007 Dustin ML, Starr T, Coombs D, Majeau GR, Meier W, Hochman PS, Douglass A, Vale R, Goldstein B, Whitty A. Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion. The Journal of Biological Chemistry. 282: 34748-57. PMID 17911103 DOI: 10.1074/Jbc.M705616200  0.346
2006 Utzny C, Coombs D, Müller S, Valitutti S. Analysis of peptide/MHC-induced TCR downregulation: deciphering the triggering kinetics. Cell Biochemistry and Biophysics. 46: 101-11. PMID 17012752 DOI: 10.1385/Cbb:46:2:101  0.44
2006 He X, Coombs D, Myszka DG, Goldstein B. A theoretical and experimental study of competition between solution and surface receptors for ligand in a Biacore flow cell. Bulletin of Mathematical Biology. 68: 1125-50. PMID 16804651 DOI: 10.1007/S11538-006-9093-9  0.35
2005 González PA, Carreño LJ, Coombs D, Mora JE, Palmieri E, Goldstein B, Nathenson SG, Kalergis AM. T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell. Proceedings of the National Academy of Sciences of the United States of America. 102: 4824-9. PMID 15772168 DOI: 10.1073/Pnas.0500922102  0.463
2005 Coombs D, Goldstein B. T cell activation: Kinetic proofreading, serial engagement and cell adhesion Journal of Computational and Applied Mathematics. 184: 121-139. DOI: 10.1016/J.Cam.2004.07.035  0.432
2004 Nelson PW, Gilchrist MA, Coombs D, Hyman JM, Perelson AS. An age-structured model of hiv infection that allows for variations in the production rate of viral particles and the death rate of productively infected cells. Mathematical Biosciences and Engineering : Mbe. 1: 267-88. PMID 20369971 DOI: 10.3934/Mbe.2004.1.267  0.329
2004 Coombs D, Goldstein B. Effects of the geometry of the immunological synapse on the delivery of effector molecules. Biophysical Journal. 87: 2215-20. PMID 15454424 DOI: 10.1529/Biophysj.104.045674  0.412
2004 Gilchrist MA, Coombs D, Perelson AS. Optimizing within-host viral fitness: infected cell lifespan and virion production rate. Journal of Theoretical Biology. 229: 281-8. PMID 15207481 DOI: 10.1016/J.Jtbi.2004.04.015  0.306
2004 Coombs D, Dembo M, Wofsy C, Goldstein B. Equilibrium thermodynamics of cell-cell adhesion mediated by multiple ligand-receptor pairs. Biophysical Journal. 86: 1408-23. PMID 14990470 DOI: 10.1016/S0006-3495(04)74211-3  0.47
2002 Coombs D, Kalergis AM, Nathenson SG, Wofsy C, Goldstein B. Activated TCRs remain marked for internalization after dissociation from pMHC. Nature Immunology. 3: 926-31. PMID 12244312 DOI: 10.1038/Ni838  0.456
2002 Coombs D, Huber G, Kessler JO, Goldstein RE. Periodic chirality transformations propagating on bacterial flagella. Physical Review Letters. 89: 118102. PMID 12225172 DOI: 10.1103/Physrevlett.89.118102  0.463
2001 Wofsy C, Coombs D, Goldstein B. Calculations show substantial serial engagement of T cell receptors Biophysical Journal. 80: 606-612. PMID 11159429 DOI: 10.1016/S0006-3495(01)76041-9  0.472
1999 Goldstein B, Coombs D, He X, Pineda AR, Wofsy C. The influence of transport on the kinetics of binding to surface receptors: application to cells and BIAcore. Journal of Molecular Recognition : Jmr. 12: 293-9. PMID 10556877 DOI: 10.1002/(Sici)1099-1352(199909/10)12:5<293::Aid-Jmr472>3.0.Co;2-M  0.375
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