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Laurent Meijer, PhD, University of Paris 1983 - Publications

Affiliations: 
Cell Cycle Group CNRS, Station Biologique de Roscoff, Roscoff, Bretagne, France 
Area:
http://www.biomedexperts.com/Profile.bme/924584/Laurent_Meijer
Website:
http://www.esi-topics.com/erf/2004/august04-LaurentMeijer.html
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Year Citation  Score
2023 Deau E, Lindberg MF, Miege F, Roche D, George N, George P, Krämer A, Knapp S, Meijer L. Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B. Journal of Medicinal Chemistry. PMID 37487467 DOI: 10.1021/acs.jmedchem.3c00884  0.398
2023 Meijer L, Dube F, Guerrier P. Trifluoperazine-Sensitive Step during Sea Urchin, Echiuroid and Pelecypod Egg Activation: (trifluoperazine/calmodulin/calcium/maturation/fertilization). Development, Growth & Differentiation. 25: 469-475. PMID 37282030 DOI: 10.1111/j.1440-169X.1983.00469.x  0.526
2023 Lindberg MF, Deau E, Arfwedson J, George N, George P, Alfonso P, Corrionero A, Meijer L. Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases. Journal of Medicinal Chemistry. PMID 36876904 DOI: 10.1021/acs.jmedchem.2c02068  0.42
2022 Sunkari YK, Meijer L, Flajolet M. The protein kinase CK1: Inhibition, activation, and possible allosteric modulation. Frontiers in Molecular Biosciences. 9: 916232. PMID 36090057 DOI: 10.3389/fmolb.2022.916232  0.392
2021 Tahtouh T, Durieu E, Villiers B, Bruyère C, Nguyen TL, Fant X, Ahn KH, Khurana L, Deau E, Lindberg MF, Sévère E, Miege F, Roche D, Limanton E, L'Helgoual'ch JM, ... ... Meijer L, et al. Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. Journal of Medicinal Chemistry. PMID 34928152 DOI: 10.1021/acs.jmedchem.1c01141  0.404
2021 Bourahla K, Guihéneuf S, Limanton E, Paquin L, Le Guével R, Charlier T, Rahmouni M, Durieu E, Lozach O, Carreaux F, Meijer L, Bazureau JP. Design and Microwave Synthesis of New (5) 5-Arylidene-2-thioxo-1,3-thiazolinidin-4-one and (5) 2-Amino-5-arylidene-1,3-thiazol-4(5)-one as New Inhibitors of Protein Kinase DYRK1A. Pharmaceuticals (Basel, Switzerland). 14. PMID 34832868 DOI: 10.3390/ph14111086  0.305
2021 Lindberg MF, Meijer L. Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview. International Journal of Molecular Sciences. 22. PMID 34205123 DOI: 10.3390/ijms22116047  0.329
2020 Loidreau Y, Dubouilh-Benard C, Nourrisson MR, Loaëc N, Meijer L, Besson T, Marchand P. Exploring Kinase Inhibition Properties of 9-pyrimido[5,4-]- and [4,5-]indol-4-amine Derivatives. Pharmaceuticals (Basel, Switzerland). 13. PMID 32397570 DOI: 10.3390/ph13050089  0.349
2019 Fruit C, Couly F, Bhansali R, Rammohan M, Lindberg MF, Crispino JD, Meijer L, Besson T. Biological Characterization of 8-Cyclopropyl-2-(pyridin-3-yl)thiazolo[5,4-]quinazolin-9(8)-one, a Promising Inhibitor of DYRK1A. Pharmaceuticals (Basel, Switzerland). 12. PMID 31861110 DOI: 10.3390/Ph12040185  0.339
2019 Lechner C, Flaßhoff M, Falke H, Preu L, Loaëc N, Meijer L, Knapp S, Chaikuad A, Kunick C. []-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors. Molecules (Basel, Switzerland). 24. PMID 31766108 DOI: 10.3390/molecules24224090  0.376
2018 Couly F, Harari M, Dubouilh-Benard C, Bailly L, Petit E, Diharce J, Bonnet P, Meijer L, Fruit C, Besson T. Development of Kinase Inhibitors via Metal-Catalyzed C⁻H Arylation of 8-Alkyl-thiazolo[5,4-]-quinazolin-9-ones Designed by Fragment-Growing Studies. Molecules (Basel, Switzerland). 23. PMID 30158487 DOI: 10.3390/molecules23092181  0.34
2018 Walter A, Chaikuad A, Helmer R, Loaëc N, Preu L, Ott I, Knapp S, Meijer L, Kunick C. Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype. Plos One. 13: e0196761. PMID 29723265 DOI: 10.1371/journal.pone.0196761  0.384
2018 Meine R, Becker W, Falke H, Preu L, Loaëc N, Meijer L, Kunick C. Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design. Molecules (Basel, Switzerland). 23. PMID 29364148 DOI: 10.3390/molecules23020064  0.348
2017 Loaëc N, Attanasio E, Villiers B, Durieu E, Tahtouh T, Cam M, Davis RA, Alencar A, Roué M, Bourguet-Kondracki ML, Proksch P, Limanton E, Guiheneuf S, Carreaux F, Bazureau JP, ... ... Meijer L, et al. Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases. Marine Drugs. 15. PMID 29039762 DOI: 10.3390/Md15100316  0.393
2017 Nguyen TL, Fruit C, Hérault Y, Meijer L, Besson T. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature. Expert Opinion On Therapeutic Patents. 1-17. PMID 28766366 DOI: 10.1080/13543776.2017.1360285  0.398
2017 Karthikeyan C, Jharia P, Waiker DK, Nusbaum AC, Amawi H, Kirwen EM, Christman R, Arudra SKC, Meijer L, Tiwari AK, Trivedi P. N-(1H-Pyrazol-3-yl)quinazolin-4-amines as a novel class of casein kinase 1δ/ε inhibitors: Synthesis, biological evaluation and molecular modeling studies. Bioorganic & Medicinal Chemistry Letters. PMID 28487075 DOI: 10.1016/j.bmcl.2017.04.080  0.358
2016 Walter A, Chaikuad A, Loaëc N, Preu L, Knapp S, Meijer L, Kunick C, Koch O. Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening. Molecular Informatics. PMID 28000414 DOI: 10.1002/minf.201600123  0.381
2016 Bendjeddou LZ, Loaëc N, Villiers B, Prina E, Späth GF, Galons H, Meijer L, Oumata N. Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor. European Journal of Medicinal Chemistry. 125: 696-709. PMID 27721154 DOI: 10.1016/j.ejmech.2016.09.064  0.344
2016 Labrière C, Lozach O, Blairvacq M, Meijer L, Guillou C. Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors. European Journal of Medicinal Chemistry. 124: 920-934. PMID 27676471 DOI: 10.1016/J.Ejmech.2016.08.069  0.354
2016 Zeinyeh W, Esvan YJ, Nauton L, Loaëc N, Meijer L, Théry V, Anizon F, Giraud F, Moreau P. Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 27469128 DOI: 10.1016/j.bmcl.2016.07.032  0.362
2016 Esvan YJ, Zeinyeh W, Boibessot T, Nauton L, Théry V, Knapp S, Chaikuad A, Loaëc N, Meijer L, Anizon F, Giraud F, Moreau P. Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure. European Journal of Medicinal Chemistry. 118: 170-177. PMID 27128181 DOI: 10.1016/j.ejmech.2016.04.004  0.311
2015 Boulahjar R, Ouach A, Bourg S, Bonnet P, Lozach O, Meijer L, Guguen-Guillouzo C, Le Guevel R, Lazar S, Akssira M, Troin Y, Guillaumet G, Routier S. Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors. European Journal of Medicinal Chemistry. 101: 274-87. PMID 26142492 DOI: 10.1016/J.Ejmech.2015.06.046  0.382
2015 Falke H, Chaikuad A, Becker A, Loaëc N, Lozach O, Abu Jhaisha S, Becker W, Jones PG, Preu L, Baumann K, Knapp S, Meijer L, Kunick C. 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A. Journal of Medicinal Chemistry. 58: 3131-43. PMID 25730262 DOI: 10.1021/jm501994d  0.333
2014 Houzé S, Hoang NT, Lozach O, Le Bras J, Meijer L, Galons H, Demange L. Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, are new anti-malarial agents. Molecules (Basel, Switzerland). 19: 15237-57. PMID 25251193 DOI: 10.3390/Molecules190915237  0.34
2014 Putey A, Fournet G, Lozach O, Perrin L, Meijer L, Joseph B. Synthesis and biological evaluation of tetrahydro[1,4]diazepino[1,2-a]indol-1-ones as cyclin-dependent kinase inhibitors. European Journal of Medicinal Chemistry. 83: 617-29. PMID 24998602 DOI: 10.1016/j.ejmech.2014.06.063  0.384
2014 Jarry M, Lecointre C, Malleval C, Desrues L, Schouft MT, Lejoncour V, Liger F, Lyvinec G, Joseph B, Loaëc N, Meijer L, Honnorat J, Gandolfo P, Castel H. Impact of meriolins, a new class of cyclin-dependent kinase inhibitors, on malignant glioma proliferation and neo-angiogenesis. Neuro-Oncology. 16: 1484-98. PMID 24891448 DOI: 10.1093/Neuonc/Nou102  0.335
2014 Waiker DK, Karthikeyan C, Poongavanam V, Kongsted J, Lozach O, Meijer L, Trivedi P. Synthesis, biological evaluation and molecular modelling studies of 4-anilinoquinazoline derivatives as protein kinase inhibitors. Bioorganic & Medicinal Chemistry. 22: 1909-15. PMID 24530227 DOI: 10.1016/J.Bmc.2014.01.044  0.322
2014 Rachidi N, Taly JF, Durieu E, Leclercq O, Aulner N, Prina E, Pescher P, Notredame C, Meijer L, Späth GF. Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection. Antimicrobial Agents and Chemotherapy. 58: 1501-15. PMID 24366737 DOI: 10.1128/AAC.02022-13  0.351
2014 Fant X, Durieu E, Chicanne G, Payrastre B, Sbrissa D, Shisheva A, Limanton E, Carreaux F, Bazureau JP, Meijer L. cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease. Molecular Pharmacology. 85: 441-50. PMID 24366666 DOI: 10.1124/Mol.113.090837  0.357
2014 Delehouzé C, Godl K, Loaëc N, Bruyère C, Desban N, Oumata N, Galons H, Roumeliotis TI, Giannopoulou EG, Grenet J, Twitchell D, Lahti J, Mouchet N, Galibert MD, Garbis SD, ... Meijer L, et al. CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells. Oncogene. 33: 5675-87. PMID 24317512 DOI: 10.1038/Onc.2013.513  0.369
2013 Guen VJ, Gamble C, Flajolet M, Unger S, Thollet A, Ferandin Y, Superti-Furga A, Cohen PA, Meijer L, Colas P. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. Proceedings of the National Academy of Sciences of the United States of America. 110: 19525-30. PMID 24218572 DOI: 10.1073/pnas.1306814110  0.303
2013 Deau E, Loidreau Y, Marchand P, Nourrisson MR, Loaëc N, Meijer L, Levacher V, Besson T. Synthesis of novel 7-substituted pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases. Bioorganic & Medicinal Chemistry Letters. 23: 6784-8. PMID 24176400 DOI: 10.1016/j.bmcl.2013.10.019  0.322
2013 Yoshida K, Itoyama R, Yamahira M, Tanaka J, Loaëc N, Lozach O, Durieu E, Fukuda T, Ishibashi F, Meijer L, Iwao M. Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: unique effects of the axial chirality on the selectivity of protein kinases inhibition. Journal of Medicinal Chemistry. 56: 7289-301. PMID 23981088 DOI: 10.1021/jm400719y  0.333
2013 Lewis CW, Taylor RG, Kubara PM, Marshall K, Meijer L, Golsteyn RM. A western blot assay to measure cyclin dependent kinase activity in cells or in vitro without the use of radioisotopes. Febs Letters. 587: 3089-95. PMID 23954627 DOI: 10.1016/j.febslet.2013.08.003  0.369
2013 Galons H, Oumata N, Gloulou O, Meijer L. Cyclin-dependent kinase inhibitors closer to market launch? Expert Opinion On Therapeutic Patents. 23: 945-63. PMID 23600454 DOI: 10.1517/13543776.2013.789861  0.356
2013 Marti G, Eparvier V, Morleo B, Le Ven J, Apel C, Bodo B, Amand S, Dumontet V, Lozach O, Meijer L, Guéritte F, Litaudon M. Natural aristolactams and aporphine alkaloids as inhibitors of CDK1/cyclin B and DYRK1A. Molecules (Basel, Switzerland). 18: 3018-27. PMID 23467012 DOI: 10.3390/Molecules18033018  0.308
2013 Burgy G, Tahtouh T, Durieu E, Foll-Josselin B, Limanton E, Meijer L, Carreaux F, Bazureau JP. Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines. European Journal of Medicinal Chemistry. 62: 728-37. PMID 23454515 DOI: 10.1016/j.ejmech.2013.01.035  0.328
2013 Demange L, Abdellah FN, Lozach O, Ferandin Y, Gresh N, Meijer L, Galons H. Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling. Bioorganic & Medicinal Chemistry Letters. 23: 125-31. PMID 23218601 DOI: 10.1016/j.bmcl.2012.10.141  0.365
2013 Fugel W, Oberholzer AE, Gschloessl B, Dzikowski R, Pressburger N, Preu L, Pearl LH, Baratte B, Ratin M, Okun I, Doerig C, Kruggel S, Lemcke T, Meijer L, Kunick C. 3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3. Journal of Medicinal Chemistry. 56: 264-75. PMID 23214499 DOI: 10.1021/jm301575n  0.305
2013 Demange L, Lozach O, Ferandin Y, Hoang NT, Meijer L, Galons H. Synthesis and evaluation of new potent inhibitors of CK1 and CDK5, two kinases involved in Alzheimer's disease Medicinal Chemistry Research. 22: 3247-3258. DOI: 10.1007/s00044-012-0334-1  0.33
2012 Coulibaly WK, Paquin L, Bénié A, Bekro YA, Durieux E, Meijer L, Le Guével R, Corlu A, Bazureau JP. Synthesis of New N,N'-Bis(5-arylidene-4-oxo-4,5-dihydrothiazolin-2-yl)piperazine Derivatives Under Microwave Irradiation and Preliminary Biological Evaluation. Scientia Pharmaceutica. 80: 825-36. PMID 23264934 DOI: 10.3797/scipharm.1206-04  0.305
2012 Boulahjar R, Ouach A, Matteo C, Bourg S, Ravache M, le Guével R, Marionneau S, Oullier T, Lozach O, Meijer L, Guguen-Guillouzo C, Lazar S, Akssira M, Troin Y, Guillaumet G, et al. Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts. Journal of Medicinal Chemistry. 55: 9589-606. PMID 23083119 DOI: 10.1021/Jm3008536  0.372
2012 Tahtouh T, Elkins JM, Filippakopoulos P, Soundararajan M, Burgy G, Durieu E, Cochet C, Schmid RS, Lo DC, Delhommel F, Oberholzer AE, Pearl LH, Carreaux F, Bazureau JP, Knapp S, ... Meijer L, et al. Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. Journal of Medicinal Chemistry. 55: 9312-30. PMID 22998443 DOI: 10.1021/jm301034u  0.36
2012 N'gompaza-Diarra J, Bettayeb K, Gresh N, Meijer L, Oumata N. Synthesis and biological evaluation of selective and potent cyclin-dependent kinase inhibitors. European Journal of Medicinal Chemistry. 56: 210-6. PMID 22982525 DOI: 10.1016/J.Ejmech.2012.08.033  0.414
2012 Nguyen TB, Lozach O, Surpateanu G, Wang Q, Retailleau P, Iorga BI, Meijer L, Guéritte F. Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases. Journal of Medicinal Chemistry. 55: 2811-9. PMID 22352892 DOI: 10.1021/Jm201727W  0.394
2012 Neagoie C, Vedrenne E, Buron F, Mérour JY, Rosca S, Bourg S, Lozach O, Meijer L, Baldeyrou B, Lansiaux A, Routier S. Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class. European Journal of Medicinal Chemistry. 49: 379-96. PMID 22305342 DOI: 10.1016/j.ejmech.2012.01.040  0.337
2012 Carassou P, Meijer L, Le Moulec S, Aoun J, Bengrine-Lefèvre L. [Cell cycle and molecular targets: CDK inhibition]. Bulletin Du Cancer. 99: 163-71. PMID 21737380 DOI: 10.1684/bdc.2011.1383  0.318
2011 Kassis P, Brzeszcz J, Bénéteau V, Lozach O, Meijer L, Le Guével R, Guillouzo C, LewiÅ„ski K, Bourg S, Colliandre L, Routier S, Mérour JY. Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents. European Journal of Medicinal Chemistry. 46: 5416-34. PMID 21944287 DOI: 10.1016/j.ejmech.2011.08.048  0.332
2011 Giraud F, Alves G, Debiton E, Nauton L, Théry V, Durieu E, Ferandin Y, Lozach O, Meijer L, Anizon F, Pereira E, Moreau P. Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. Journal of Medicinal Chemistry. 54: 4474-89. PMID 21623630 DOI: 10.1021/jm200464w  0.363
2011 Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, ... Meijer L, et al. Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. Journal of Medicinal Chemistry. 54: 4172-86. PMID 21615147 DOI: 10.1021/jm200274d  0.35
2011 Shengule SR, Loa-Kum-Cheung WL, Parish CR, Blairvacq M, Meijer L, Nakao Y, Karuso P. A one-pot synthesis and biological activity of ageladine A and analogues. Journal of Medicinal Chemistry. 54: 2492-503. PMID 21413800 DOI: 10.1021/Jm200039M  0.327
2011 Jain P, Flaherty PT, Yi S, Chopra I, Bleasdell G, Lipay J, Ferandin Y, Meijer L, Madura JD. Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25. Bioorganic & Medicinal Chemistry. 19: 359-73. PMID 21144757 DOI: 10.1016/J.Bmc.2010.11.022  0.328
2010 Power DP, Lozach O, Meijer L, Grayson DH, Connon SJ. Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones. Bioorganic & Medicinal Chemistry Letters. 20: 4940-4. PMID 20621478 DOI: 10.1016/j.bmcl.2010.06.024  0.337
2010 Sliman F, Blairvacq M, Durieu E, Meijer L, Rodrigo J, Desmaële D. Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase. Bioorganic & Medicinal Chemistry Letters. 20: 2801-5. PMID 20363627 DOI: 10.1016/j.bmcl.2010.03.061  0.392
2010 Galons H, Oumata N, Meijer L. Cyclin-dependent kinase inhibitors: a survey of recent patent literature. Expert Opinion On Therapeutic Patents. 20: 377-404. PMID 20180621 DOI: 10.1517/13543770903524284  0.353
2009 Beauchard A, Laborie H, Rouillard H, Lozach O, Ferandin Y, Le Guével R, Guguen-Guillouzo C, Meijer L, Besson T, Thiéry V. Synthesis and kinase inhibitory activity of novel substituted indigoids. Bioorganic & Medicinal Chemistry. 17: 6257-63. PMID 19665384 DOI: 10.1016/j.bmc.2009.07.051  0.423
2009 Chioua M, Samadi A, Soriano E, Lozach O, Meijer L, Marco-Contelles J. Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 4566-9. PMID 19615897 DOI: 10.1016/j.bmcl.2009.06.099  0.311
2009 Corbel C, Haddoub R, Guiffant D, Lozach O, Gueyrard D, Lemoine J, Ratin M, Meijer L, Bach S, Goekjian P. Identification of potential cellular targets of aloisine A by affinity chromatography. Bioorganic & Medicinal Chemistry. 17: 5572-82. PMID 19596197 DOI: 10.1016/j.bmc.2009.06.024  0.325
2009 Xingi E, Smirlis D, Myrianthopoulos V, Magiatis P, Grant KM, Meijer L, Mikros E, Skaltsounis AL, Soteriadou K. 6-Br-5methylindirubin-3'oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: exploitation of GSK-3 for treating leishmaniasis. International Journal For Parasitology. 39: 1289-303. PMID 19445946 DOI: 10.1016/j.ijpara.2009.04.005  0.319
2009 Rochais C, Duc NV, Lescot E, Sopkova-de Oliveira Santos J, Bureau R, Meijer L, Dallemagne P, Rault S. Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors. European Journal of Medicinal Chemistry. 44: 708-16. PMID 18586356 DOI: 10.1016/j.ejmech.2008.05.011  0.368
2008 Baunbaek D, Trinkler N, Ferandin Y, Lozach O, Ploypradith P, Rucirawat S, Ishibashi F, Iwao M, Meijer L. Anticancer alkaloid lamellarins inhibit protein kinases. Marine Drugs. 6: 514-27. PMID 19172192 DOI: 10.3390/md20080026  0.427
2008 Vougogiannopoulou K, Ferandin Y, Bettayeb K, Myrianthopoulos V, Lozach O, Fan Y, Johnson CH, Magiatis P, Skaltsounis AL, Mikros E, Meijer L. Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period. Journal of Medicinal Chemistry. 51: 6421-31. PMID 18816110 DOI: 10.1021/Jm800648Y  0.502
2008 Marminon C, Anizon F, Moreau P, Pfeiffer B, Pierré A, Golsteyn RM, Peixoto P, Hildebrand MP, David-Cordonnier MH, Lozach O, Meijer L, Prudhomme M. Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors. Molecular Pharmacology. 74: 1620-9. PMID 18768386 DOI: 10.1124/mol.108.049346  0.308
2008 Oumata N, Bettayeb K, Ferandin Y, Demange L, Lopez-Giral A, Goddard ML, Myrianthopoulos V, Mikros E, Flajolet M, Greengard P, Meijer L, Galons H. Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. Journal of Medicinal Chemistry. 51: 5229-42. PMID 18698753 DOI: 10.1021/jm800109e  0.392
2008 Echalier A, Bettayeb K, Ferandin Y, Lozach O, Clément M, Valette A, Liger F, Marquet B, Morris JC, Endicott JA, Joseph B, Meijer L. Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex. Journal of Medicinal Chemistry. 51: 737-51. PMID 18232649 DOI: 10.1021/jm700940h  0.376
2008 Logé C, Testard A, Thiéry V, Lozach O, Blairvacq M, Robert JM, Meijer L, Besson T. Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies. European Journal of Medicinal Chemistry. 43: 1469-77. PMID 17981370 DOI: 10.1016/j.ejmech.2007.09.020  0.349
2007 Zahler S, Tietze S, Totzke F, Kubbutat M, Meijer L, Vollmar AM, Apostolakis J. Inverse in silico screening for identification of kinase inhibitor targets. Chemistry & Biology. 14: 1207-14. PMID 18022559 DOI: 10.1016/j.chembiol.2007.10.010  0.344
2007 Bettayeb K, Tirado OM, Marionneau-Lambot S, Ferandin Y, Lozach O, Morris JC, Mateo-Lozano S, Drueckes P, Schächtele C, Kubbutat MH, Liger F, Marquet B, Joseph B, Echalier A, Endicott JA, ... ... Meijer L, et al. Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases. Cancer Research. 67: 8325-34. PMID 17804748 DOI: 10.1158/0008-5472.Can-07-1826  0.417
2007 Blondel M, Meijer L. Editorial: role of cyclin-dependent kinase-5 (Cdk5) in the central nervous system. Biotechnology Journal. 2: 914-5. PMID 17680714 DOI: 10.1002/biot.200790085  0.313
2007 Reinhardt J, Ferandin Y, Meijer L. Purification of CK1 by affinity chromatography on immobilised axin. Protein Expression and Purification. 54: 101-9. PMID 17434749 DOI: 10.1016/j.pep.2007.02.020  0.321
2006 Ferandin Y, Bettayeb K, Kritsanida M, Lozach O, Polychronopoulos P, Magiatis P, Skaltsounis AL, Meijer L. 3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents. Journal of Medicinal Chemistry. 49: 4638-49. PMID 16854069 DOI: 10.1021/jm060314i  0.319
2006 Borgne A, Versteege I, Mahé M, Studeny A, Léonce S, Naime I, Rodriguez M, Hickman JA, Meijer L, Golsteyn RM. Analysis of cyclin B1 and CDK activity during apoptosis induced by camptothecin treatment. Oncogene. 25: 7361-72. PMID 16785996 DOI: 10.1038/sj.onc.1209718  0.312
2006 Beauchard A, Ferandin Y, Frère S, Lozach O, Blairvacq M, Meijer L, Thiéry V, Besson T. Synthesis of novel 5-substituted indirubins as protein kinases inhibitors. Bioorganic & Medicinal Chemistry. 14: 6434-43. PMID 16759872 DOI: 10.1016/j.bmc.2006.05.036  0.401
2006 Barluenga S, Dakas PY, Ferandin Y, Meijer L, Winssinger N. Modular asymmetric synthesis of aigialomycin D, a kinase-inhibitory scaffold. Angewandte Chemie (International Ed. in English). 45: 3951-4. PMID 16683294 DOI: 10.1002/Anie.200600593  0.31
2006 Testard A, Logé C, Léger B, Robert JM, Lozach O, Blairvacq M, Meijer L, Thiéry V, Besson T. Thiazolo[5,4-f]quinazolin-9-ones, inhibitors of glycogen synthase kinase-3. Bioorganic & Medicinal Chemistry Letters. 16: 3419-23. PMID 16644220 DOI: 10.1016/j.bmcl.2006.04.006  0.342
2006 Laurent D, Jullian V, Parenty A, Knibiehler M, Dorin D, Schmitt S, Lozach O, Lebouvier N, Frostin M, Alby F, Maurel S, Doerig C, Meijer L, Sauvain M. Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp. Bioorganic & Medicinal Chemistry. 14: 4477-82. PMID 16513357 DOI: 10.1016/j.bmc.2006.02.026  0.374
2006 Abadi AH, Abou-Seri SM, Abdel-Rahman DE, Klein C, Lozach O, Meijer L. Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents. European Journal of Medicinal Chemistry. 41: 296-305. PMID 16494969 DOI: 10.1016/j.ejmech.2005.12.004  0.319
2005 Wu ZL, Aryal P, Lozach O, Meijer L, Guengerich FP. Biosynthesis of new indigoid inhibitors of protein kinases using recombinant cytochrome P450 2A6. Chemistry & Biodiversity. 2: 51-65. PMID 17191919 DOI: 10.1002/Cbdv.200490166  0.31
2005 Testard A, Picot L, Lozach O, Blairvacq M, Meijer L, Murillo L, Piot JM, Thiéry V, Besson T. Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 20: 557-68. PMID 16408791 DOI: 10.1080/14756360500212399  0.343
2005 Bach S, Knockaert M, Reinhardt J, Lozach O, Schmitt S, Baratte B, Koken M, Coburn SP, Tang L, Jiang T, Liang DC, Galons H, Dierick JF, Pinna LA, Meggio F, ... ... Meijer L, et al. Roscovitine targets, protein kinases and pyridoxal kinase. The Journal of Biological Chemistry. 280: 31208-19. PMID 15975926 DOI: 10.1074/Jbc.M500806200  0.376
2005 Yang H, Zheng S, Meijer L, Li SM, Leclerc S, Yu LL, Cheng JQ, Zhang SZ. Screening the active constituents of Chinese medicinal herbs as potent inhibitors of Cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2 kinase. Journal of Zhejiang University. Science. B. 6: 656-63. PMID 15973768 DOI: 10.1631/jzus.2005.B0656  0.335
2005 Kunick C, Zeng Z, Gussio R, Zaharevitz D, Leost M, Totzke F, Schächtele C, Kubbutat MH, Meijer L, Lemcke T. Structure-aided optimization of kinase inhibitors derived from alsterpaullone. Chembiochem : a European Journal of Chemical Biology. 6: 541-9. PMID 15696597 DOI: 10.1002/cbic.200400099  0.326
2005 Lu H, Chang DJ, Baratte B, Meijer L, Schulze-Gahmen U. Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. Journal of Medicinal Chemistry. 48: 737-43. PMID 15689157 DOI: 10.1021/jm049353p  0.346
2005 Mapelli M, Massimiliano L, Crovace C, Seeliger MA, Tsai LH, Meijer L, Musacchio A. Mechanism of CDK5/p25 binding by CDK inhibitors. Journal of Medicinal Chemistry. 48: 671-9. PMID 15689152 DOI: 10.1021/Jm049323M  0.313
2004 Rochais C, Lescot E, Lisowski V, Lepailleur A, Santos JS, Bureau R, Dallemagne P, Meijer L, Rault S. Synthesis and biological evaluation of thienopyrrolizines, a new family of CDK/GSK-3 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 19: 585-93. PMID 15662962 DOI: 10.1080/14756360400004565  0.306
2004 Grant KM, Dunion MH, Yardley V, Skaltsounis AL, Marko D, Eisenbrand G, Croft SL, Meijer L, Mottram JC. Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity. Antimicrobial Agents and Chemotherapy. 48: 3033-42. PMID 15273118 DOI: 10.1128/AAC.48.8.3033-3042.2004  0.385
2004 Guengerich FP, Sorrells JL, Schmitt S, Krauser JA, Aryal P, Meijer L. Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis. Journal of Medicinal Chemistry. 47: 3236-41. PMID 15163202 DOI: 10.1021/Jm030561B  0.341
2004 Wan Y, Hur W, Cho CY, Liu Y, Adrian FJ, Lozach O, Bach S, Mayer T, Fabbro D, Meijer L, Gray NS. Synthesis and target identification of hymenialdisine analogs. Chemistry & Biology. 11: 247-59. PMID 15123286 DOI: 10.1016/j.chembiol.2004.01.015  0.378
2004 Knockaert M, Blondel M, Bach S, Leost M, Elbi C, Hager GL, Nagy SR, Han D, Denison M, Ffrench M, Ryan XP, Magiatis P, Polychronopoulos P, Greengard P, Skaltsounis L, ... Meijer L, et al. Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene. 23: 4400-12. PMID 15077192 DOI: 10.1038/Sj.Onc.1207535  0.426
2004 Gompel M, Soulié C, Ceballos-Picot I, Meijer L. Expression and activity of cyclin-dependent kinases and glycogen synthase kinase-3 during NT2 neuronal differentiation. Neuro-Signals. 13: 134-43. PMID 15067201 DOI: 10.1159/000076567  0.361
2004 Gompel M, Leost M, De Kier Joffe EB, Puricelli L, Franco LH, Palermo J, Meijer L. Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum. Bioorganic & Medicinal Chemistry Letters. 14: 1703-7. PMID 15026054 DOI: 10.1016/j.bmcl.2004.01.050  0.414
2004 Droucheau E, Primot A, Thomas V, Mattei D, Knockaert M, Richardson C, Sallicandro P, Alano P, Jafarshad A, Baratte B, Kunick C, Parzy D, Pearl L, Doerig C, Meijer L. Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors. Biochimica Et Biophysica Acta. 1697: 181-96. PMID 15023360 DOI: 10.1016/j.bbapap.2003.11.023  0.324
2004 Erdogan-Orhan I, Sener B, de Rosa S, Perez-Baz J, Lozach O, Leost M, Rakhilin S, Meijer L. Polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase CDC25A. Natural Product Research. 18: 1-9. PMID 14974610 DOI: 10.1080/1478641031000111534  0.386
2004 Polychronopoulos P, Magiatis P, Skaltsounis AL, Myrianthopoulos V, Mikros E, Tarricone A, Musacchio A, Roe SM, Pearl L, Leost M, Greengard P, Meijer L. Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. Journal of Medicinal Chemistry. 47: 935-46. PMID 14761195 DOI: 10.1021/jm031016d  0.391
2003 Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chemistry & Biology. 10: 1255-66. PMID 14700633 DOI: 10.1016/j.chembiol.2003.11.010  0.339
2003 Fischer PM, Endicott J, Meijer L. Cyclin-dependent kinase inhibitors. Progress in Cell Cycle Research. 5: 235-48. PMID 14593718  0.378
2003 Malgrange B, Knockaert M, Belachew S, Nguyen L, Moonen G, Meijer L, Lefebvre PP. The inhibition of cyclin-dependent kinases induces differentiation of supernumerary hair cells and Deiters' cells in the developing organ of Corti. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 2136-8. PMID 12958157 DOI: 10.1096/Fj.03-0035Fje  0.334
2003 Brachwitz K, Voigt B, Meijer L, Lozach O, Schächtele C, Molnár J, Hilgeroth A. Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties. Journal of Medicinal Chemistry. 46: 876-9. PMID 12593668 DOI: 10.1021/jm021090g  0.38
2003 Mettey Y, Gompel M, Thomas V, Garnier M, Leost M, Ceballos-Picot I, Noble M, Endicott J, Vierfond JM, Meijer L. Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. Journal of Medicinal Chemistry. 46: 222-36. PMID 12519061 DOI: 10.1021/Jm020319P  0.369
2002 Biernat J, Wu YZ, Timm T, Zheng-Fischhöfer Q, Mandelkow E, Meijer L, Mandelkow EM. Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. Molecular Biology of the Cell. 13: 4013-28. PMID 12429843 DOI: 10.1091/Mbc.02-03-0046  0.314
2002 Doerig C, Meijer L, Mottram JC. Protein kinases as drug targets in parasitic protozoa. Trends in Parasitology. 18: 366-71. PMID 12377287  0.358
2002 Knockaert M, Greengard P, Meijer L. Pharmacological inhibitors of cyclin-dependent kinases. Trends in Pharmacological Sciences. 23: 417-25. PMID 12237154 DOI: 10.1016/S0165-6147(02)02071-0  0.334
2002 Knockaert M, Lenormand P, Gray N, Schultz P, Pouysségur J, Meijer L. p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol. Oncogene. 21: 6413-24. PMID 12226745 DOI: 10.1038/Sj.Onc.1205908  0.322
2002 Knockaert M, Meijer L. Identifying in vivo targets of cyclin-dependent kinase inhibitors by affinity chromatography. Biochemical Pharmacology. 64: 819-25. PMID 12213575  0.354
2002 Chang YT, Choi G, Bae YS, Burdett M, Moon HS, Lee JW, Gray NS, Schultz PG, Meijer L, Chung SK, Choi KY, Suh PG, Ryu SH. Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem : a European Journal of Chemical Biology. 3: 897-901. PMID 12210991 DOI: 10.1002/1439-7633(20020902)3:9<897::Aid-Cbic897>3.0.Co;2-B  0.341
2002 Ortega MA, Montoya ME, Zarranz B, Jaso A, Aldana I, Leclerc S, Meijer L, Monge A. Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorganic & Medicinal Chemistry. 10: 2177-84. PMID 11983514  0.405
2002 Knockaert M, Wieking K, Schmitt S, Leost M, Grant KM, Mottram JC, Kunick C, Meijer L. Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor. The Journal of Biological Chemistry. 277: 25493-501. PMID 11964410 DOI: 10.1074/jbc.M202651200  0.307
2002 Schoepfer J, Fretz H, Chaudhuri B, Muller L, Seeber E, Meijer L, Lozach O, Vangrevelinghe E, Furet P. Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics. Journal of Medicinal Chemistry. 45: 1741-7. PMID 11960485  0.309
2001 Loukaci A, Le Saout I, Samadi M, Leclerc S, Damiens E, Meijer L, Debitus C, Guyot M. Coscinosulfate, a CDC25 phosphatase inhibitor from the sponge Coscinoderma mathewsi. Bioorganic & Medicinal Chemistry. 9: 3049-54. PMID 11597488  0.375
2001 Damiens E, Baratte B, Marie D, Eisenbrand G, Meijer L. Anti-mitotic properties of indirubin-3'-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest. Oncogene. 20: 3786-97. PMID 11439342 DOI: 10.1038/sj.onc.1204503  0.34
2001 Harmse L, van Zyl R, Gray N, Schultz P, Leclerc S, Meijer L, Doerig C, Havlik I. Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum. Biochemical Pharmacology. 62: 341-8. PMID 11434907 DOI: 10.1016/S0006-2952(01)00644-X  0.353
2001 Davies TG, Tunnah P, Meijer L, Marko D, Eisenbrand G, Endicott JA, Noble ME. Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate. Structure (London, England : 1993). 9: 389-97. PMID 11377199  0.332
2001 Meijer L, Knockaert M, Damiens E. [Prevention of chemotherapy-induced alopecia by cyclin-dependant kinase inhibitors]. Bulletin Du Cancer. 88: 347-50. PMID 11371368  0.36
2001 Dorin D, Le Roch K, Sallicandro P, Alano P, Parzy D, Poullet P, Meijer L, Doerig C. Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum Biochemical properties and possible involvement in MAPK regulation. European Journal of Biochemistry / Febs. 268: 2600-8. PMID 11322879 DOI: 10.1046/j.1432-1327.2001.02151.x  0.406
2001 Leclerc S, Garnier M, Hoessel R, Marko D, Bibb JA, Snyder GL, Greengard P, Biernat J, Wu YZ, Mandelkow EM, Eisenbrand G, Meijer L. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? The Journal of Biological Chemistry. 276: 251-60. PMID 11013232 DOI: 10.1074/jbc.M002466200  0.354
2000 Andreani A, Cavalli A, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Recanatini M, Garnier M, Meijer L. Imidazo[2,1 -b]thiazolylmethylene- and indolylmethylene-2-indolinones: a new class of cyclin-dependent kinase inhibitors. Design, synthesis, and CDK1/cyclin B inhibition. Anti-Cancer Drug Design. 15: 447-52. PMID 11716438  0.375
2000 Meijer L. Cyclin-dependent kinases inhibitors as potential anticancer, antineurodegenerative, antiviral and antiparasitic agents. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 3: 83-88. PMID 11498372 DOI: 10.1054/drup.2000.0129  0.338
2000 Primot A, Baratte B, Gompel M, Borgne A, Liabeuf S, Romette JL, Jho EH, Costantini F, Meijer L. Purification of GSK-3 by affinity chromatography on immobilized axin. Protein Expression and Purification. 20: 394-404. PMID 11087679 DOI: 10.1006/Prep.2000.1321  0.319
2000 Leost M, Schultz C, Link A, Wu YZ, Biernat J, Mandelkow EM, Bibb JA, Snyder GL, Greengard P, Zaharevitz DW, Gussio R, Senderowicz AM, Sausville EA, Kunick C, Meijer L. Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. European Journal of Biochemistry / Febs. 267: 5983-94. PMID 10998059 DOI: 10.1046/j.1432-1327.2000.01673.x  0.367
2000 Jeong HW, Kim MR, Son KH, Han MY, Ha JH, Garnier M, Meijer L, Kwon BM. Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1. Bioorganic & Medicinal Chemistry Letters. 10: 1819-22. PMID 10969976 DOI: 10.1016/S0960-894X(00)00357-7  0.354
2000 Knockaert M, Gray N, Damiens E, Chang YT, Grellier P, Grant K, Fergusson D, Mottram J, Soete M, Dubremetz JF, Le Roch K, Doerig C, Schultz P, Meijer L. Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors. Chemistry & Biology. 7: 411-22. PMID 10873834 DOI: 10.1016/S1074-5521(00)00124-1  0.377
2000 Damiens E, Meijer L. [Chemical inhibitors of cyclic-dependent kinases: preclinical and clinical study]. Pathologie-Biologie. 48: 340-51. PMID 10858966  0.328
2000 Legraverend M, Tunnah P, Noble M, Ducrot P, Ludwig O, Grierson DS, Leost M, Meijer L, Endicott J. Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2-inhibitor complex. Journal of Medicinal Chemistry. 43: 1282-92. PMID 10753466 DOI: 10.1021/Jm9911130  0.309
2000 Le Roch K, Sestier C, Dorin D, Waters N, Kappes B, Chakrabarti D, Meijer L, Doerig C. Activation of a Plasmodium falciparum cdc2-related kinase by heterologous p25 and cyclin H. Functional characterization of a P. falciparum cyclin homologue. The Journal of Biological Chemistry. 275: 8952-8. PMID 10722743  0.365
2000 Meijer L, Thunnissen AM, White AW, Garnier M, Nikolic M, Tsai LH, Walter J, Cleverley KE, Salinas PC, Wu YZ, Biernat J, Mandelkow EM, Kim SH, Pettit GR. Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chemistry & Biology. 7: 51-63. PMID 10662688 DOI: 10.1016/S1074-5521(00)00063-6  0.415
2000 Mermillod P, Tomanek M, Marchal R, Meijer L. High developmental competence of cattle oocytes maintained at the germinal vesicle stage for 24 hours in culture by specific inhibition of MPF kinase activity. Molecular Reproduction and Development. 55: 89-95. PMID 10602278 DOI: 10.1002/(SICI)1098-2795(200001)55:1<89::AID-MRD12>3.0.CO;2-M  0.308
1999 Giocanti N, Sadri R, Legraverend M, Ludwig O, Bisagni E, Leclerc S, Meijer L, Favaudon V. In vitro evaluation of a novel 2,6,9-trisubstituted purine acting as a cyclin-dependent kinase inhibitor. Annals of the New York Academy of Sciences. 886: 180-2. PMID 10667214  0.383
1999 Bibb JA, Snyder GL, Nishi A, Yan Z, Meijer L, Fienberg AA, Tsai LH, Kwon YT, Girault JA, Czernik AJ, Huganir RL, Hemmings HC, Nairn AC, Greengard P. Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature. 402: 669-71. PMID 10604473 DOI: 10.1038/45251  0.404
1999 Hoessel R, Leclerc S, Endicott JA, Nobel ME, Lawrie A, Tunnah P, Leost M, Damiens E, Marie D, Marko D, Niederberger E, Tang W, Eisenbrand G, Meijer L. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nature Cell Biology. 1: 60-7. PMID 10559866 DOI: 10.1038/9035  0.356
1999 Gray N, Détivaud L, Doerig C, Meijer L. ATP-site directed inhibitors of cyclin-dependent kinases. Current Medicinal Chemistry. 6: 859-75. PMID 10495356  0.351
1999 Legraverend M, Ludwig O, Bisagni E, Leclerc S, Meijer L, Giocanti N, Sadri R, Favaudon V. Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors. Bioorganic & Medicinal Chemistry. 7: 1281-93. PMID 10465404  0.312
1999 Sausville EA, Zaharevitz D, Gussio R, Meijer L, Louarn-Leost M, Kunick C, Schultz R, Lahusen T, Headlee D, Stinson S, Arbuck SG, Senderowicz A. Cyclin-dependent kinases: initial approaches to exploit a novel therapeutic target. Pharmacology & Therapeutics. 82: 285-92. PMID 10454206  0.318
1999 Meijer L, Leclerc S, Leost M. Properties and potential-applications of chemical inhibitors of cyclin-dependent kinases. Pharmacology & Therapeutics. 82: 279-84. PMID 10454205  0.321
1999 Détivaud L, Pettit GR, Meijer L. Characterization of a novel cdk1-related kinase. European Journal of Biochemistry / Febs. 264: 55-66. PMID 10447673 DOI: 10.1046/J.1432-1327.1999.00576.X  0.413
1999 Schultz C, Link A, Leost M, Zaharevitz DW, Gussio R, Sausville EA, Meijer L, Kunick C. Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. Journal of Medicinal Chemistry. 42: 2909-19. PMID 10425100 DOI: 10.1021/jm9900570  0.328
1999 Chang YT, Gray NS, Rosania GR, Sutherlin DP, Kwon S, Norman TC, Sarohia R, Leost M, Meijer L, Schultz PG. Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chemistry & Biology. 6: 361-75. PMID 10375538 DOI: 10.1016/S1074-5521(99)80048-9  0.333
1999 Zaharevitz DW, Gussio R, Leost M, Senderowicz AM, Lahusen T, Kunick C, Meijer L, Sausville EA. Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Research. 59: 2566-9. PMID 10363974  0.345
1999 Borgne A, Ostvold AC, Flament S, Meijer L. Intra-M phase-promoting factor phosphorylation of cyclin B at the prophase/metaphase transition. The Journal of Biological Chemistry. 274: 11977-86. PMID 10207019  0.331
1998 Legraverend M, Ludwig O, Bisagni E, Leclerc S, Meijer L. Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases. Bioorganic & Medicinal Chemistry Letters. 8: 793-8. PMID 9871543  0.337
1998 Alessi F, Quarta S, Savio M, Riva F, Rossi L, Stivala LA, Scovassi AI, Meijer L, Prosperi E. The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Experimental Cell Research. 245: 8-18. PMID 9828096 DOI: 10.1006/excr.1998.4216  0.373
1998 Gray NS, Wodicka L, Thunnissen AM, Norman TC, Kwon S, Espinoza FH, Morgan DO, Barnes G, LeClerc S, Meijer L, Kim SH, Lockhart DJ, Schultz PG. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science (New York, N.Y.). 281: 533-8. PMID 9677190 DOI: 10.1126/Science.281.5376.533  0.353
1997 An B, Dineley K, Zhang L, Termin T, Meijer L, Dou Q. Involvement of RB kinases and phosphatases in life and death decisions. Oncology Reports. 4: 1129-34. PMID 21590208 DOI: 10.3892/Or.4.6.1129  0.401
1997 Pippin JW, Qu Q, Meijer L, Shankland SJ. Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist. The Journal of Clinical Investigation. 100: 2512-20. PMID 9366565 DOI: 10.1172/JCI119793  0.349
1997 Krucher NA, Meijer L, Roberts MH. The cyclin-dependent kinase (cdk) inhibitors, olomoucine and roscovitine, alter the expression of a molluscan circadian pacemaker. Cellular and Molecular Neurobiology. 17: 495-507. PMID 9353591  0.344
1997 Schutte B, Nieland L, van Engeland M, Henfling ME, Meijer L, Ramaekers FC. The effect of the cyclin-dependent kinase inhibitor olomoucine on cell cycle kinetics. Experimental Cell Research. 236: 4-15. PMID 9344580 DOI: 10.1006/excr.1997.3700  0.351
1997 Meijer L, Kim SH. Chemical inhibitors of cyclin-dependent kinases. Methods in Enzymology. 283: 113-28. PMID 9251015 DOI: 10.1016/S0076-6879(97)83011-X  0.36
1997 Havlícek L, Hanus J, Veselý J, Leclerc S, Meijer L, Shaw G, Strnad M. Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds. Journal of Medicinal Chemistry. 40: 408-12. PMID 9046330 DOI: 10.1021/jm960666x  0.356
1997 Meijer L, Borgne A, Mulner O, Chong JP, Blow JJ, Inagaki N, Inagaki M, Delcros JG, Moulinoux JP. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. European Journal of Biochemistry / Febs. 243: 527-36. PMID 9030781 DOI: 10.1111/J.1432-1033.1997.T01-2-00527.X  0.423
1997 De Azevedo WF, Leclerc S, Meijer L, Havlicek L, Strnad M, Kim SH. Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. European Journal of Biochemistry / Febs. 243: 518-26. PMID 9030780  0.34
1996 Meijer L. Chemical inhibitors of cyclin-dependent kinases. Trends in Cell Biology. 6: 393-7. PMID 15157522  0.36
1996 Borgne A, Meijer L. Sequential dephosphorylation of p34(cdc2) on Thr-14 and Tyr-15 at the prophase/metaphase transition. The Journal of Biological Chemistry. 271: 27847-54. PMID 8910383  0.352
1995 Meijer L. Chemical inhibitors of cyclin-dependent kinases. Progress in Cell Cycle Research. 1: 351-63. PMID 9552377  0.36
1995 Schulze-Gahmen U, Brandsen J, Jones HD, Morgan DO, Meijer L, Vesely J, Kim SH. Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine. Proteins. 22: 378-91. PMID 7479711 DOI: 10.1002/Prot.340220408  0.35
1994 Azzi L, Meijer L, Ostvold AC, Lew J, Wang JH. Purification of a 15-kDa cdk4- and cdk5-binding protein. The Journal of Biological Chemistry. 269: 13279-88. PMID 8175758  0.343
1992 Baratte B, Meijer L, Galaktionov K, Beach D. Screening for antimitotic compounds using the cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2/cyclin Bcdc13 protein kinase. Anticancer Research. 12: 873-80. PMID 1320360  0.376
1991 Meijer L, Ostvold AC, Walass SI, Lund T, Laland SG. High-mobility-group proteins P1, I and Y as substrates of the M-phase-specific p34cdc2/cyclincdc13 kinase. European Journal of Biochemistry / Febs. 196: 557-67. PMID 2013279  0.365
1991 Meijer L, Arion D. Negative control of cdc2 kinase activation by cAMP in starfish oocytes. Cold Spring Harbor Symposia On Quantitative Biology. 56: 591-8. PMID 1668090  0.345
1990 Pondaven P, Meijer L, Beach D. Activation of M-phase-specific histone H1 kinase by modification of the phosphorylation of its p34cdc2 and cyclin components. Genes & Development. 4: 9-17. PMID 2155162  0.309
1989 Meijer L, Arion D, Golsteyn R, Pines J, Brizuela L, Hunt T, Beach D. Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase. The Embo Journal. 8: 2275-82. PMID 2551679  0.324
1989 Arion D, Meijer L. M-phase-specific protein kinase from mitotic sea urchin eggs: cyclic activation depends on protein synthesis and phosphorylation but does not require DNA or RNA synthesis. Experimental Cell Research. 183: 361-75. PMID 2475356  0.328
1988 Pelech SL, Tombes RM, Meijer L, Krebs EG. Activation of myelin basic protein kinases during echinoderm oocyte maturation and egg fertilization. Developmental Biology. 130: 28-36. PMID 3181631 DOI: 10.1016/0012-1606(88)90410-1  0.355
1988 Meijer L, Pondaven P. Cyclic activation of histone H1 kinase during sea urchin egg mitotic divisions. Experimental Cell Research. 174: 116-29. PMID 2826194  0.382
1987 Meijer L, Pelech SL, Krebs EG. Differential regulation of histone H1 and ribosomal S6 kinases during sea star oocyte maturation. Biochemistry. 26: 7968-74. PMID 2827766 DOI: 10.1021/Bi00398A063  0.365
1982 Meijer L, Paul M, Epel D. Stimulation of protein phosphorylation during fertilization-induced maturation of Urechis caupo oocytes. Developmental Biology. 94: 62-70. PMID 6295850 DOI: 10.1016/0012-1606(82)90068-9  0.556
Low-probability matches (unlikely to be authored by this person)
2014 Houzé S, Hoang NT, Lozach O, Le Bras J, Meijer L, Galons H, Demange L. Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, as new anti-malarial agents. Molecules (Basel, Switzerland). 19: 15237-57. PMID 25255764 DOI: 10.3390/molecules190915237  0.3
2009 Akue-Gedu R, Debiton E, Ferandin Y, Meijer L, Prudhomme M, Anizon F, Moreau P. Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins. Bioorganic & Medicinal Chemistry. 17: 4420-4. PMID 19477650 DOI: 10.1016/j.bmc.2009.05.017  0.297
2018 Billot K, Coquil C, Villiers B, Josselin-Foll B, Desban N, Delehouze C, Oumata N, Le Meur Y, Boletta A, Weimbs T, Grosch M, Witzgall R, Saunier S, Fischer E, Pontoglio M, ... ... Meijer L, et al. Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8. American Journal of Physiology. Renal Physiology. PMID 29537311 DOI: 10.1152/Ajprenal.00489.2017  0.297
2012 Grabher P, Durieu E, Kouloura E, Halabalaki M, Skaltsounis LA, Meijer L, Hamburger M, Potterat O. Library-based discovery of DYRK1A/CLK1 inhibitors from natural product extracts. Planta Medica. 78: 951-6. PMID 22673832 DOI: 10.1055/s-0031-1298625  0.297
1999 Collin O, Meijer L. KID, a Kinase Inhibitor Database project. Pharmacology & Therapeutics. 82: 165-8. PMID 10454195  0.297
2014 Bruel A, Bénéteau R, Chabanne M, Lozach O, Le Guevel R, Ravache M, Bénédetti H, Meijer L, Logé C, Robert JM. Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 5037-40. PMID 25248682 DOI: 10.1016/j.bmcl.2014.09.017  0.295
2000 Corellou F, Bisgrove SR, Kropf DL, Meijer L, Kloareg B, Bouget FY. A S/M DNA replication checkpoint prevents nuclear and cytoplasmic events of cell division including centrosomal axis alignment and inhibits activation of cyclin-dependent kinase-like proteins in fucoid zygotes. Development (Cambridge, England). 127: 1651-60. PMID 10725241  0.295
2007 Myrianthopoulos V, Magiatis P, Ferandin Y, Skaltsounis AL, Meijer L, Mikros E. An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. Journal of Medicinal Chemistry. 50: 4027-37. PMID 17665890 DOI: 10.1021/jm070077z  0.294
2013 Bruyère C, Meijer L. Targeting cyclin-dependent kinases in anti-neoplastic therapy. Current Opinion in Cell Biology. 25: 772-9. PMID 24011867 DOI: 10.1016/j.ceb.2013.08.004  0.294
2001 Marko D, Schätzle S, Friedel A, Genzlinger A, Zankl H, Meijer L, Eisenbrand G. Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells. British Journal of Cancer. 84: 283-9. PMID 11161389 DOI: 10.1054/bjoc.2000.1546  0.293
2008 Niu X, Dahse HM, Menzel KD, Lozach O, Walther G, Meijer L, Grabley S, Sattler I. Butyrolactone I derivatives from Aspergillus terreus carrying an unusual sulfate moiety. Journal of Natural Products. 71: 689-92. PMID 18271552 DOI: 10.1021/np070341r  0.29
2001 Escargueil AE, Plisov SY, Skladanowski A, Borgne A, Meijer L, Gorbsky GJ, Larsen AK. Recruitment of cdc2 kinase by DNA topoisomerase II is coupled to chromatin remodeling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 2288-90. PMID 11511510 DOI: 10.1096/Fj.00-0726Fje  0.29
2009 Popowycz F, Fournet G, Schneider C, Bettayeb K, Ferandin Y, Lamigeon C, Tirado OM, Mateo-Lozano S, Notario V, Colas P, Bernard P, Meijer L, Joseph B. Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue. Journal of Medicinal Chemistry. 52: 655-63. PMID 19128055 DOI: 10.1021/Jm801340Z  0.29
2008 Jacquemard U, Dias N, Lansiaux A, Bailly C, Logé C, Robert JM, Lozach O, Meijer L, Mérour JY, Routier S. Synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and cytotoxic agents. Bioorganic & Medicinal Chemistry. 16: 4932-53. PMID 18439832 DOI: 10.1016/j.bmc.2008.03.034  0.289
2014 Dehbi O, Tikad A, Bourg S, Bonnet P, Lozach O, Meijer L, Aadil M, Akssira M, Guillaumet G, Routier S. Synthesis and optimization of an original V-shaped collection of 4-7-disubstituted pyrido[3,2-d]pyrimidines as CDK5 and DYRK1A inhibitors. European Journal of Medicinal Chemistry. 80: 352-63. PMID 24793883 DOI: 10.1016/j.ejmech.2014.04.055  0.288
2022 Gupta P, Strange K, Telange R, Guo A, Hatch H, Sobh A, Elie J, Carter AM, Totenhagen J, Tan C, Sonawane YA, Neuzil J, Natarajan A, Ovens AJ, Oakhill JS, ... ... Meijer L, et al. Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer. Cell Reports. 40: 111218. PMID 35977518 DOI: 10.1016/j.celrep.2022.111218  0.286
2016 Durieu E, Prina E, Leclercq O, Oumata N, Gaboriaud-Kolar N, Vougogiannopoulou K, Aulner N, Defontaine A, No JH, Ruchaud S, Skaltsounis AL, Galons H, Späth GF, Meijer L, Rachidi N. From drug screening to target deconvolution: A target-based drug discovery pipeline using Leishmania casein kinase 1 isoform 2 to identify compounds with anti-leishmanial activity. Antimicrobial Agents and Chemotherapy. PMID 26902771 DOI: 10.1128/Aac.00021-16  0.285
2013 Myrianthopoulos V, Kritsanida M, Gaboriaud-Kolar N, Magiatis P, Ferandin Y, Durieu E, Lozach O, Cappel D, Soundararajan M, Filippakopoulos P, Sherman W, Knapp S, Meijer L, Mikros E, Skaltsounis AL. Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases. Acs Medicinal Chemistry Letters. 4: 22-26. PMID 23336033 DOI: 10.1021/ml300207a  0.284
2005 Braña MF, Cacho M, García ML, Mayoral EP, López B, de Pascual-Teresa B, Ramos A, Acero N, Llinares F, Muñoz-Mingarro D, Lozach O, Meijer L. Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases. Journal of Medicinal Chemistry. 48: 6843-54. PMID 16250643 DOI: 10.1021/jm058013g  0.282
1988 Arion D, Meijer L, Brizuela L, Beach D. cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF. Cell. 55: 371-8. PMID 2844417  0.281
2014 Foucourt A, Hédou D, Dubouilh-Benard C, Désiré L, Casagrande AS, Leblond B, Loäec N, Meijer L, Besson T. Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part I. Molecules (Basel, Switzerland). 19: 15546-71. PMID 25268714 DOI: 10.3390/molecules191015546  0.279
2006 Ribas J, Bettayeb K, Ferandin Y, Knockaert M, Garrofé-Ochoa X, Totzke F, Schächtele C, Mester J, Polychronopoulos P, Magiatis P, Skaltsounis AL, Boix J, Meijer L. 7-Bromoindirubin-3'-oxime induces caspase-independent cell death. Oncogene. 25: 6304-18. PMID 16702956 DOI: 10.1038/sj.onc.1209648  0.279
2006 Sondhi SM, Singh N, Kumar A, Lozach O, Meijer L. Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff's bases. Bioorganic & Medicinal Chemistry. 14: 3758-65. PMID 16480879 DOI: 10.1016/j.bmc.2006.01.054  0.278
2015 Loidreau Y, Deau E, Marchand P, Nourrisson MR, Logé C, Coadou G, Loaëc N, Meijer L, Besson T. Synthesis and molecular modelling studies of 8-arylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors. European Journal of Medicinal Chemistry. 92: 124-34. PMID 25549552 DOI: 10.1016/j.ejmech.2014.12.038  0.277
2003 Meijer L, Raymond E. Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials. Accounts of Chemical Research. 36: 417-25. PMID 12809528 DOI: 10.1021/ar0201198  0.277
2000 Tintignac LA, Leibovitch MP, Kitzmann M, Fernandez A, Ducommun B, Meijer L, Leibovitch SA. Cyclin E-cdk2 phosphorylation promotes late G1-phase degradation of MyoD in muscle cells. Experimental Cell Research. 259: 300-7. PMID 10942602 DOI: 10.1006/excr.2000.4973  0.276
2013 Braig S, Kressirer CA, Liebl J, Bischoff F, Zahler S, Meijer L, Vollmar AM. Indirubin derivative 6BIO suppresses metastasis. Cancer Research. 73: 6004-12. PMID 23946383 DOI: 10.1158/0008-5472.CAN-12-4358  0.275
2004 Meijer L, Flajolet M, Greengard P. Pharmacological inhibitors of glycogen synthase kinase 3. Trends in Pharmacological Sciences. 25: 471-80. PMID 15559249 DOI: 10.1016/j.tips.2004.07.006  0.275
2016 Hédou D, Godeau J, Loaëc N, Meijer L, Fruit C, Besson T. Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases. Molecules (Basel, Switzerland). 21. PMID 27144552 DOI: 10.3390/molecules21050578  0.273
2014 Beniddir MA, Le Borgne E, Iorga BI, Loaëc N, Lozach O, Meijer L, Awang K, Litaudon M. Acridone alkaloids from Glycosmis chlorosperma as DYRK1A inhibitors. Journal of Natural Products. 77: 1117-22. PMID 24798019 DOI: 10.1021/Np400856H  0.273
2013 Cosimo E, McCaig AM, Carter-Brzezinski LJ, Wheadon H, Leach MT, Le Ster K, Berthou C, Durieu E, Oumata N, Galons H, Meijer L, Michie AM. Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 2393-405. PMID 23532892 DOI: 10.1158/1078-0432.CCR-12-2170  0.272
2012 Loidreau Y, Marchand P, Dubouilh-Benard C, Nourrisson MR, Duflos M, Lozach O, Loaëc N, Meijer L, Besson T. Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors. European Journal of Medicinal Chemistry. 58: 171-83. PMID 23124214 DOI: 10.1016/j.ejmech.2012.10.006  0.269
2008 Bettayeb K, Oumata N, Echalier A, Ferandin Y, Endicott JA, Galons H, Meijer L. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 27: 5797-807. PMID 18574471 DOI: 10.1038/onc.2008.191  0.267
2023 Lindberg MF, Deau E, Miege F, Greverie M, Roche D, George N, George P, Merlet L, Gavard J, Brugman SJT, Aret E, Tinnemans P, de Gelder R, Sadownik J, Verhofstad E, ... ... Meijer L, et al. Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer's Disease Drug Candidate. Journal of Medicinal Chemistry. PMID 38051674 DOI: 10.1021/acs.jmedchem.3c01888  0.264
2016 Ouach A, Boulahjar R, Vala C, Bourg S, Bonnet P, Guguen-Guillouzo C, Ravache M, Le Guevel R, Lozach O, Lazar S, Troin Y, Meijer L, Ruchaud S, Akssira M, Guillaumet G, et al. Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors. European Journal of Medicinal Chemistry. 115: 311-325. PMID 27019296 DOI: 10.1016/J.Ejmech.2016.02.072  0.263
2012 Apel C, Dumontet V, Lozach O, Meijer L, Guéritte F, Litaudon M. Phenanthrene derivatives from Appendicula reflexa as new CDK1/cyclin B inhibitors Phytochemistry Letters. 5: 814-818. DOI: 10.1016/J.Phytol.2012.09.008  0.262
1997 Planchais S, Glab N, Tréhin C, Perennes C, Bureau JM, Meijer L, Bergounioux C. Roscovitine, a novel cyclin-dependent kinase inhibitor, characterizes restriction point and G2/M transition in tobacco BY-2 cell suspension. The Plant Journal : For Cell and Molecular Biology. 12: 191-202. PMID 9263460  0.26
2016 Orban OC, Korn RS, Benítez D, Medeiros A, Preu L, Loaëc N, Meijer L, Koch O, Comini MA, Kunick C. 5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms. Bioorganic & Medicinal Chemistry. PMID 27349574 DOI: 10.1016/j.bmc.2016.06.023  0.258
2011 Szypowska AA, de Ruiter H, Meijer LA, Smits LM, Burgering BM. Oxidative stress-dependent regulation of Forkhead box O4 activity by nemo-like kinase. Antioxidants & Redox Signaling. 14: 563-78. PMID 20874444 DOI: 10.1089/ars.2010.3243  0.257
2004 Kunick C, Lauenroth K, Leost M, Meijer L, Lemcke T. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorganic & Medicinal Chemistry Letters. 14: 413-6. PMID 14698171  0.255
2005 Voigt B, Meijer L, Lozach O, Schächtele C, Totzke F, Hilgeroth A. Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes. Bioorganic & Medicinal Chemistry Letters. 15: 823-5. PMID 15664865 DOI: 10.1016/j.bmcl.2004.10.091  0.252
2014 Siffroi-Fernandez S, Dulong S, Li XM, Filipski E, Gréchez-Cassiau A, Peteri-Brünback B, Meijer L, Lévi F, Teboul M, Delaunay F. Functional genomics identify Birc5/survivin as a candidate gene involved in the chronotoxicity of cyclin-dependent kinase inhibitors. Cell Cycle (Georgetown, Tex.). 13: 984-91. PMID 24552823 DOI: 10.4161/cc.27868  0.252
2008 Olivier D, Poincelot MA, Douillard S, Lefevre C, Moureau J, Ferandin Y, Bettayeb K, Xiao Z, Magiatis P, Skaltsounis L, Meijer L, Patrice T. Photoreactivity of indirubin derivatives. Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society For Photobiology. 7: 328-36. PMID 18389150 DOI: 10.1039/b711261k  0.252
2006 Soos TJ, Meijer L, Nelson PJ. CDK/GSK-3 inhibitors as a new approach for the treatment of proliferative renal diseases. Drug News & Perspectives. 19: 325-8. PMID 16971968 DOI: 10.1358/dnp.2006.19.6.985939  0.252
2005 Tang L, Li MH, Cao P, Wang F, Chang WR, Bach S, Reinhardt J, Ferandin Y, Galons H, Wan Y, Gray N, Meijer L, Jiang T, Liang DC. Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives. The Journal of Biological Chemistry. 280: 31220-9. PMID 15985434 DOI: 10.1074/Jbc.M500805200  0.251
2012 Kubara PM, Kernéis-Golsteyn S, Studény A, Lanser BB, Meijer L, Golsteyn RM. Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents. The Biochemical Journal. 446: 373-81. PMID 22686412 DOI: 10.1042/BJ20120385  0.251
1991 Meijer L, Azzi L, Wang JY. Cyclin B targets p34cdc2 for tyrosine phosphorylation. The Embo Journal. 10: 1545-54. PMID 1709096  0.251
2010 Bettayeb K, Baunbæk D, Delehouze C, Loaëc N, Hole AJ, Baumli S, Endicott JA, Douc-Rasy S, Bénard J, Oumata N, Galons H, Meijer L. CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells. Genes & Cancer. 1: 369-80. PMID 21779453 DOI: 10.1177/1947601910369817  0.25
2016 Llona-Minguez S, Höglund A, Jacques S, Johansson L, Calderón-Montaño JM, Claesson M, Loseva O, Valerie N, Lundbäck T, Piedrafita J, Maga G, Crespan E, Meijer L, Burgos-Moron E, Baranczewski P, et al. Discovery of the first potent and selective inhibitors of the human dCTP pyrophosphatase 1 (dCTPase). Journal of Medicinal Chemistry. PMID 26771665 DOI: 10.1021/Acs.Jmedchem.5B01741  0.25
2011 Gloerich M, Vliem MJ, Prummel E, Meijer LA, Rensen MG, Rehmann H, Bos JL. The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity. The Journal of Cell Biology. 193: 1009-20. PMID 21670213 DOI: 10.1083/Jcb.201011126  0.249
2000 Kunick C, Schultz C, Lemcke T, Zaharevitz DW, Gussio R, Jalluri RK, Sausville EA, Leost M, Meijer L. 2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity. Bioorganic & Medicinal Chemistry Letters. 10: 567-9. PMID 10741555 DOI: 10.1016/S0960-894X(00)00048-2  0.249
2004 Kunick C, Lauenroth K, Wieking K, Xie X, Schultz C, Gussio R, Zaharevitz D, Leost M, Meijer L, Weber A, Jørgensen FS, Lemcke T. Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones. Journal of Medicinal Chemistry. 47: 22-36. PMID 14695817 DOI: 10.1021/jm0308904  0.248
2000 Gussio R, Zaharevitz DW, McGrath CF, Pattabiraman N, Kellogg GE, Schultz C, Link A, Kunick C, Leost M, Meijer L, Sausville EA. Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition. Anti-Cancer Drug Design. 15: 53-66. PMID 10888036  0.247
2017 El Hage K, Piquemal JP, Oumata N, Meijer L, Galons H, Gresh N. A Simple Isomerization of the Purine Scaffold of a Kinase Inhibitor, Roscovitine, Affords a Four- to Seven-Fold Enhancement of Its Affinity for Four CDKs. Could This Be Traced Back to Conjugation-Induced Stiffenings/Loosenings of Rotational Barriers? Acs Omega. 2: 3467-3474. PMID 30023695 DOI: 10.1021/acsomega.7b00471  0.247
1994 Glab N, Labidi B, Qin LX, Trehin C, Bergounioux C, Meijer L. Olomoucine, an inhibitor of the cdc2/cdk2 kinases activity, blocks plant cells at the G1 to S and G2 to M cell cycle transitions. Febs Letters. 353: 207-11. PMID 7523194  0.245
2012 Debray J, Bonte S, Lozach O, Meijer L, Demeunynck M. Catalyst-free synthesis of quinazolin-4-ones from (hetero)aryl-guanidines: application to the synthesis of pyrazolo[4,3-f]quinazolin-9-ones, a new family of DYRK1A inhibitors. Molecular Diversity. 16: 659-67. PMID 22991074 DOI: 10.1007/s11030-012-9397-7  0.241
1991 Rialet V, Meijer L. A new screening test for antimitotic compounds using the universal M phase-specific protein kinase, p34cdc2/cyclin Bcdc13, affinity-immobilized on p13suc1-coated microtitration plates. Anticancer Research. 11: 1581-90. PMID 1660692  0.24
2007 Guiffant D, Tribouillard D, Gug F, Galons H, Meijer L, Blondel M, Bach S. Identification of intracellular targets of small molecular weight chemical compounds using affinity chromatography. Biotechnology Journal. 2: 68-75. PMID 17225251 DOI: 10.1002/biot.200600223  0.239
2016 Esposito G, Bourguet-Kondracki ML, Mai LH, Longeon A, Teta R, Meijer L, Van Soest R, Mangoni A, Costantino V. Chloromethylhalicyclamine B, a Marine-Derived Protein Kinase CK1δ/ε Inhibitor. Journal of Natural Products. 79: 2953-2960. PMID 27933894 DOI: 10.1021/acs.jnatprod.6b00939  0.239
2010 Menn B, Bach S, Blevins TL, Campbell M, Meijer L, Timsit S. Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models. Plos One. 5: e12117. PMID 20711428 DOI: 10.1371/journal.pone.0012117  0.239
2015 Troadec S, Blairvacq M, Oumata N, Galons H, Meijer L, Berthou C. Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell lines. Journal of Biomedical Science. 22: 57. PMID 26184865 DOI: 10.1186/s12929-015-0163-x  0.237
1989 Meijer L, Dostmann W, Genieser HG, Butt E, Jastorff B. Starfish oocyte maturation: evidence for a cyclic AMP-dependent inhibitory pathway. Developmental Biology. 133: 58-66. PMID 2540053  0.236
2013 Loidreau Y, Marchand P, Dubouilh-Benard C, Nourrisson MR, Duflos M, Loaëc N, Meijer L, Besson T. Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases. European Journal of Medicinal Chemistry. 59: 283-95. PMID 23237976 DOI: 10.1016/j.ejmech.2012.11.030  0.236
2006 Iurisci I, Filipski E, Reinhardt J, Bach S, Gianella-Borradori A, Iacobelli S, Meijer L, Lévi F. Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor. Cancer Research. 66: 10720-8. PMID 17108108 DOI: 10.1158/0008-5472.CAN-06-2086  0.236
2006 Savio M, Cerri M, Cazzalini O, Perucca P, Stivala LA, Pichierri P, Franchitto A, Meijer L, Prosperi E. Replication-dependent DNA damage response triggered by roscovitine induces an uncoupling of DNA replication proteins. Cell Cycle (Georgetown, Tex.). 5: 2153-9. PMID 16969115  0.236
2019 Souchet B, Audrain M, Billard JM, Dairou J, Fol R, Orefice NS, Tada S, Gu Y, Dufayet-Chaffaud G, Limanton E, Carreaux F, Bazureau JP, Alves S, Meijer L, Janel N, et al. Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice. Acta Neuropathologica Communications. 7: 46. PMID 30885273 DOI: 10.1186/s40478-019-0678-6  0.235
2007 Doerig C, Meijer L. Antimalarial drug discovery: targeting protein kinases. Expert Opinion On Therapeutic Targets. 11: 279-90. PMID 17298288 DOI: 10.1517/14728222.11.3.279  0.233
2012 Deslandes S, Lamoral-Theys D, Frongia C, Chassaing S, Bruyère C, Lozach O, Meijer L, Ducommun B, Kiss R, Delfourne E. Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide. European Journal of Medicinal Chemistry. 54: 626-36. PMID 22809559 DOI: 10.1016/j.ejmech.2012.06.012  0.231
2012 Bruel A, Logé C, Tauzia ML, Ravache M, Le Guevel R, Guillouzo C, Lohier JF, Oliveira Santos JS, Lozach O, Meijer L, Ruchaud S, Bénédetti H, Robert JM. Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitors. European Journal of Medicinal Chemistry. 57: 225-33. PMID 23063566 DOI: 10.1016/j.ejmech.2012.09.001  0.231
2010 Becker A, Kohfeld S, Lader A, Preu L, Pies T, Wieking K, Ferandin Y, Knockaert M, Meijer L, Kunick C. Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH). European Journal of Medicinal Chemistry. 45: 335-42. PMID 19906467 DOI: 10.1016/j.ejmech.2009.10.018  0.23
2010 Magiatis P, Polychronopoulos P, Skaltsounis AL, Lozach O, Meijer L, Miller DB, O'Callaghan JP. Indirubins deplete striatal monoamines in the Intact and MPTP-treated mouse brain and block kainate-induced striatal astrogliosis. Neurotoxicology and Teratology. 32: 212-9. PMID 20034560 DOI: 10.1016/j.ntt.2009.12.005  0.227
2012 Coulibaly WK, Paquin L, Bénie A, Bekro YA, Durieu E, Meijer L, Bazureau JP. Synthesis of N,N'-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinases. European Journal of Medicinal Chemistry. 58: 581-90. PMID 23174317 DOI: 10.1016/j.ejmech.2012.08.044  0.226
2011 Dorin-Semblat D, Schmitt S, Semblat JP, Sicard A, Reininger L, Goldring D, Patterson S, Quashie N, Chakrabarti D, Meijer L, Doerig C. Plasmodium falciparum NIMA-related kinase Pfnek-1: sex specificity and assessment of essentiality for the erythrocytic asexual cycle. Microbiology (Reading, England). 157: 2785-94. PMID 21757488 DOI: 10.1099/mic.0.049023-0  0.226
2001 Ouarzane-Amara M, Franetich JF, Mazier D, Pettit GR, Meijer L, Doerig C, Desportes-Livage I. In vitro activities of two antimitotic compounds, pancratistatin and 7-deoxynarciclasine, against Encephalitozoon intestinalis, a microsporidium causing infections in humans. Antimicrobial Agents and Chemotherapy. 45: 3409-15. PMID 11709316 DOI: 10.1128/Aac.45.12.3409-3415.2001  0.226
2006 Routier S, Mérour JY, Dias N, Lansiaux A, Bailly C, Lozach O, Meijer L. Synthesis and biological evaluation of novel phenylcarbazoles as potential anticancer agents. Journal of Medicinal Chemistry. 49: 789-99. PMID 16420063 DOI: 10.1021/jm050945x  0.224
2004 Pies T, Schaper KJ, Leost M, Zaharevitz DW, Gussio R, Meijer L, Kunicke C. CDK1-inhibitory activity of paullones depends on electronic properties of 9-substituents. Archiv Der Pharmazie. 337: 486-92. PMID 15362121 DOI: 10.1002/ardp.200300870  0.223
2008 Stukenbrock H, Mussmann R, Geese M, Ferandin Y, Lozach O, Lemcke T, Kegel S, Lomow A, Burk U, Dohrmann C, Meijer L, Austen M, Kunick C. 9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication. Journal of Medicinal Chemistry. 51: 2196-207. PMID 18345612 DOI: 10.1021/jm701582f  0.221
2016 Husson H, Moreno S, Smith LA, Smith MM, Russo RJ, Pitstick R, Sergeev M, Ledbetter SR, Bukanov NO, Lane M, Zhang K, Billot K, Carlson G, Shah J, Meijer L, et al. Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis. Human Molecular Genetics. PMID 27053712 DOI: 10.1093/Hmg/Ddw093  0.22
2000 Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C. Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. The Journal of Biological Chemistry. 275: 390-7. PMID 10617630 DOI: 10.1074/Jbc.275.1.390  0.219
2002 Schang LM, Bantly A, Knockaert M, Shaheen F, Meijer L, Malim MH, Gray NS, Schaffer PA. Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins. Journal of Virology. 76: 7874-82. PMID 12097601 DOI: 10.1128/Jvi.76.15.7874-7882.2002  0.218
2012 Marhadour S, Marchand P, Pagniez F, Bazin MA, Picot C, Lozach O, Ruchaud S, Antoine M, Meijer L, Rachidi N, Le Pape P. Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents. European Journal of Medicinal Chemistry. 58: 543-56. PMID 23164660 DOI: 10.1016/j.ejmech.2012.10.048  0.217
2001 Wang D, de la Fuente C, Deng L, Wang L, Zilberman I, Eadie C, Healey M, Stein D, Denny T, Harrison LE, Meijer L, Kashanchi F. Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors. Journal of Virology. 75: 7266-79. PMID 11461999 DOI: 10.1128/Jvi.75.16.7266-7279.2001  0.209
1994 Loyer P, Glaise D, Cariou S, Baffet G, Meijer L, Guguen-Guillouzo C. Expression and activation of cdks (1 and 2) and cyclins in the cell cycle progression during liver regeneration. The Journal of Biological Chemistry. 269: 2491-500. PMID 8300575  0.206
2003 Bach S, Talarek N, Andrieu T, Vierfond JM, Mettey Y, Galons H, Dormont D, Meijer L, Cullin C, Blondel M. Isolation of drugs active against mammalian prions using a yeast-based screening assay. Nature Biotechnology. 21: 1075-81. PMID 12910243 DOI: 10.1038/nbt855  0.206
2013 Meijer LA, Zhou H, Chan OY, Altelaar AF, Hennrich ML, Mohammed S, Bos JL, Heck AJ. Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway. Molecular Biosystems. 9: 732-49. PMID 23403867 DOI: 10.1039/C3Mb25524G  0.203
2008 Bettayeb K, Sallam H, Ferandin Y, Popowycz F, Fournet G, Hassan M, Echalier A, Bernard P, Endicott J, Joseph B, Meijer L. N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine. Molecular Cancer Therapeutics. 7: 2713-24. PMID 18790752 DOI: 10.1158/1535-7163.MCT-08-0080  0.203
2004 Duensing S, Duensing A, Lee DC, Edwards KM, Piboonniyom SO, Manuel E, Skaltsounis L, Meijer L, Münger K. Cyclin-dependent kinase inhibitor indirubin-3'-oxime selectively inhibits human papillomavirus type 16 E7-induced numerical centrosome anomalies. Oncogene. 23: 8206-15. PMID 15378001 DOI: 10.1038/Sj.Onc.1208012  0.2
2005 Blondel M, Bach S, Bamps S, Dobbelaere J, Wiget P, Longaretti C, Barral Y, Meijer L, Peter M. Degradation of Hof1 by SCF(Grr1) is important for actomyosin contraction during cytokinesis in yeast. The Embo Journal. 24: 1440-52. PMID 15775961 DOI: 10.1038/Sj.Emboj.7600627  0.199
2016 Hédou D, Dubouilh-Benard C, Loaëc N, Meijer L, Fruit C, Besson T. Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation. Molecules (Basel, Switzerland). 21. PMID 27322235 DOI: 10.3390/molecules21060794  0.198
2010 Debdab M, Renault S, Lozach O, Meijer L, Paquin L, Carreaux F, Bazureau JP. Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors. European Journal of Medicinal Chemistry. 45: 805-10. PMID 19879673 DOI: 10.1016/j.ejmech.2009.10.009  0.197
2010 Laronze-Cochard M, Cochard F, Daras E, Lansiaux A, Brassart B, Vanquelef E, Prost E, Nuzillard JM, Baldeyrou B, Goosens JF, Lozach O, Meijer L, Riou JF, Henon E, Sapi J. Synthesis and biological evaluation of new penta- and heptacyclic indolo- and quinolinocarbazole ring systems obtained via Pd(0) catalysed reductive N-heteroannulation. Organic & Biomolecular Chemistry. 8: 4625-36. PMID 20734015 DOI: 10.1039/c0ob00149j  0.196
2002 Vogel L, Baratte B, Détivaud L, Azzi L, Leopold P, Meijer L. Molecular cloning and characterisation of p15(CDK-BP), a novel CDK-binding protein. Biochimica Et Biophysica Acta. 1589: 219-31. PMID 12007796  0.195
2004 Meijer L. [Mediterranean purple indirubins: a source of GSK-3 inhibitors]. Mã©Decine Sciences : M/S. 20: 516-8. PMID 15190467 DOI: 10.1051/medsci/2004205516  0.195
2015 Ebada SS, Linh MH, Longeon A, de Voogd NJ, Durieu E, Meijer L, Bourguet-Kondracki ML, Singab AN, Müller WE, Proksch P. Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa. Natural Product Research. 29: 231-8. PMID 25116895 DOI: 10.1080/14786419.2014.947496  0.195
2014 Guiheneuf S, Paquin L, Carreaux F, Durieu E, Roisnel T, Meijer L, Bazureau JP. New 5-ylidene rhodanine derivatives based on the dispacamide A model. Molecular Diversity. 18: 375-88. PMID 24584455 DOI: 10.1007/s11030-014-9509-7  0.191
2001 Amara MO, Franetich JF, Bouladoux N, Mazier D, Eisenbrand G, Marko D, Meijer L, Doerig C, Desportes-Livage I. In vitro activity of antimitotic compounds against the microsporidium Encephalitozoon intestinalis. The Journal of Eukaryotic Microbiology. 99S-100S. PMID 11906097 DOI: 10.1111/J.1550-7408.2001.TB00469.X  0.19
2015 He F, Mai LH, Longeon A, Copp BR, Loaëc N, Bescond A, Meijer L, Bourguet-Kondracki ML. Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp. Marine Drugs. 13: 2617-28. PMID 25927661 DOI: 10.3390/Md13052617  0.189
2002 Wieking K, Knockaert M, Leost M, Zaharevitz DW, Meijer L, Kunick C. Synthesis of paullones with aminoalkyl side chains. Archiv Der Pharmazie. 335: 311-7. PMID 12207280 DOI: 10.1002/1521-4184(200209)335:7<311::AID-ARDP311>3.0.CO;2-F  0.189
2007 Vandromme L, Legraverend M, Kreimerman S, Lozach O, Meijer L, Grierson DS. A Pd(0) based cross-coupling approach to the synthesis of 2-amidopurines and their evaluation as CDK inhibitors. Bioorganic & Medicinal Chemistry. 15: 130-41. PMID 17064911 DOI: 10.1016/j.bmc.2006.10.003  0.188
2014 Maiwald F, Benítez D, Charquero D, Dar MA, Erdmann H, Preu L, Koch O, Hölscher C, Loaëc N, Meijer L, Comini MA, Kunick C. 9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma. European Journal of Medicinal Chemistry. 83: 274-83. PMID 24973661 DOI: 10.1016/j.ejmech.2014.06.020  0.186
2005 Sondhi SM, Singh N, Lahoti AM, Bajaj K, Kumar A, Lozach O, Meijer L. Synthesis of acridinyl-thiazolino derivatives and their evaluation for anti-inflammatory, analgesic and kinase inhibition activities. Bioorganic & Medicinal Chemistry. 13: 4291-9. PMID 15927836 DOI: 10.1016/j.bmc.2005.04.017  0.186
2017 Myrianthopoulos V, Lozach O, Zareifi D, Alexopoulos L, Meijer L, Gorgoulis VG, Mikros E. Combined Virtual and Experimental Screening for CK1 Inhibitors Identifies a Modulator of p53 and Reveals Important Aspects of in Silico Screening Performance. International Journal of Molecular Sciences. 18. PMID 28984824 DOI: 10.3390/Ijms18102102  0.186
2000 Meijer LK, Schesser K, Wolf-Watz H, Sassone-Corsi P, Pettersson S. The bacterial protein YopJ abrogates multiple signal transduction pathways that converge on the transcription factor CREB. Cellular Microbiology. 2: 231-8. PMID 11207579 DOI: 10.1046/J.1462-5822.2000.00049.X  0.185
2008 Obligado SH, Ibraghimov-Beskrovnaya O, Zuk A, Meijer L, Nelson PJ. CDK/GSK-3 inhibitors as therapeutic agents for parenchymal renal diseases. Kidney International. 73: 684-90. PMID 18094678 DOI: 10.1038/sj.ki.5002731  0.184
2008 Lambert LA, Qiao N, Hunt KK, Lambert DH, Mills GB, Meijer L, Keyomarsi K. Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model. Cancer Research. 68: 7966-74. PMID 18829554 DOI: 10.1158/0008-5472.Can-08-1333  0.182
2004 Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nature Medicine. 10: 55-63. PMID 14702635 DOI: 10.1038/nm979  0.182
2011 Kehn-Hall K, Guendel I, Carpio L, Skaltsounis L, Meijer L, Al-Harthi L, Steiner JP, Nath A, Kutsch O, Kashanchi F. Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors. Virology. 415: 56-68. PMID 21514616 DOI: 10.1016/J.Virol.2011.03.025  0.181
2012 Narayanan A, Sampey G, Van Duyne R, Guendel I, Kehn-Hall K, Roman J, Currer R, Galons H, Oumata N, Joseph B, Meijer L, Caputi M, Nekhai S, Kashanchi F. Use of ATP analogs to inhibit HIV-1 transcription. Virology. 432: 219-31. PMID 22771113 DOI: 10.1016/J.Virol.2012.06.007  0.181
2010 Carpio L, Klase Z, Coley W, Guendel I, Choi S, Van Duyne R, Narayanan A, Kehn-Hall K, Meijer L, Kashanchi F. microRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection. Journal of Rnai and Gene Silencing : An International Journal of Rna and Gene Targeting Research. 6: 386-400. PMID 20628499  0.18
2010 Mittendorf EA, Liu Y, Tucker SL, McKenzie T, Qiao N, Akli S, Biernacka A, Liu Y, Meijer L, Keyomarsi K, Hunt KK. A novel interaction between HER2/neu and cyclin E in breast cancer. Oncogene. 29: 3896-907. PMID 20453888 DOI: 10.1038/Onc.2010.151  0.175
2008 Laoukili J, Alvarez M, Meijer LA, Stahl M, Mohammed S, Kleij L, Heck AJ, Medema RH. Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain. Molecular and Cellular Biology. 28: 3076-87. PMID 18285455 DOI: 10.1128/Mcb.01710-07  0.172
2006 Vandromme L, Piguel S, Lozach O, Meijer L, Legraverend M, Grierson DS. Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 3144-6. PMID 16616489 DOI: 10.1016/j.bmcl.2006.03.060  0.172
2013 Hochard A, Oumata N, Bettayeb K, Gloulou O, Fant X, Durieu E, Buron N, Porceddu M, Borgne-Sanchez A, Galons H, Flajolet M, Meijer L. Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease? Journal of Alzheimer's Disease : Jad. 35: 107-20. PMID 23364140 DOI: 10.3233/JAD-121777  0.17
2018 Marlier Q, Jibassia F, Verteneuil S, Linden J, Kaldis P, Meijer L, Nguyen L, Vandenbosch R, Malgrange B. Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death. Cell Death Discovery. 4: 43. PMID 29581894 DOI: 10.1038/S41420-018-0044-7  0.169
2007 Kitani K, Oguma S, Nishiki T, Ohmori I, Galons H, Matsui H, Meijer L, Tomizawa K. A Cdk5 inhibitor enhances the induction of insulin secretion by exendin-4 both in vitro and in vivo. The Journal of Physiological Sciences : Jps. 57: 235-9. PMID 17854513 DOI: 10.2170/physiolsci.RP006607  0.168
2014 Braig S, Bischoff F, Abhari BA, Meijer L, Fulda S, Skaltsounis L, Vollmar AM. The pleiotropic profile of the indirubin derivative 6BIO overcomes TRAIL resistance in cancer. Biochemical Pharmacology. 91: 157-67. PMID 25069048 DOI: 10.1016/j.bcp.2014.07.009  0.168
2012 Bukanov NO, Moreno SE, Natoli TA, Rogers KA, Smith LA, Ledbetter SR, Oumata N, Galons H, Meijer L, Ibraghimov-Beskrovnaya O. CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD. Cell Cycle (Georgetown, Tex.). 11: 4040-6. PMID 23032260 DOI: 10.4161/cc.22375  0.167
2012 Bettayeb K, Oumata N, Zhang Y, Luo W, Bustos V, Galons H, Greengard P, Meijer L, Flajolet M. Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 5115-23. PMID 22972917 DOI: 10.1096/Fj.12-212985  0.164
2011 Akli S, Van Pelt CS, Bui T, Meijer L, Keyomarsi K. Cdk2 is required for breast cancer mediated by the low-molecular-weight isoform of cyclin E. Cancer Research. 71: 3377-86. PMID 21385896 DOI: 10.1158/0008-5472.Can-10-4086  0.164
2012 Nanos-Webb A, Jabbour NA, Multani AS, Wingate H, Oumata N, Galons H, Joseph B, Meijer L, Hunt KK, Keyomarsi K. Targeting low molecular weight cyclin E (LMW-E) in breast cancer. Breast Cancer Research and Treatment. 132: 575-88. PMID 21695458 DOI: 10.1007/S10549-011-1638-4  0.156
2020 Guyot AC, Leuxe C, Disdier C, Oumata N, Costa N, Roux GL, Fernandez-Varela P, Duchon A, Charbonnier JB, Herault Y, Pavoni S, Galons H, Andriambeloson E, Wagner S, Meijer L, et al. A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment. Scientific Reports. 10: 1143. PMID 31980673 DOI: 10.1038/s41598-020-57560-3  0.152
2012 Da Silva PP, Meijer L. [Search for natural substances with therapeutic activity: Pierre Potier (1934-2006)]. Mã©Decine Sciences : M/S. 28: 534-42. PMID 22643009 DOI: 10.1051/medsci/2012285020  0.149
2024 Lana-Elola E, Aoidi R, Llorian M, Gibbins D, Buechsenschuetz C, Bussi C, Flynn H, Gilmore T, Watson-Scales S, Haugsten Hansen M, Hayward D, Song OR, Brault V, Herault Y, Deau E, ... Meijer L, et al. Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome. Science Translational Medicine. 16: eadd6883. PMID 38266108 DOI: 10.1126/scitranslmed.add6883  0.146
2021 Meijer L, Hery-Arnaud G, Leven C, Nowak E, Hillion S, Renaudineau Y, Durieu I, Chiron R, Prevotat A, Fajac I, Hubert D, Murris-Espin M, Huge S, Danner-Boucher I, Ravoninjatovo B, et al. Safety and pharmacokinetics of Roscovitine (Seliciclib) in cystic fibrosis patients chronically infected with Pseudomonas aeruginosa, a randomized, placebo-controlled study. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 34961705 DOI: 10.1016/j.jcf.2021.10.013  0.145
2018 Mavrogeni ME, Pronios F, Zareifi D, Vasilakaki S, Lozach O, Alexopoulos L, Meijer L, Myrianthopoulos V, Mikros E. A facile consensus ranking approach enhances virtual screening robustness and identifies a cell-active DYRK1α inhibitor. Future Medicinal Chemistry. 10: 2411-2430. PMID 30325204 DOI: 10.4155/Fmc-2018-0198  0.141
2004 Chausson F, Paterson LA, Betteley KA, Hannah L, Meijer L, Bentley MG. CDK1/cyclin B regulation during oocyte maturation in two closely related lugworm species, Arenicola marina and Arenicola defodiens. Development, Growth & Differentiation. 46: 71-82. PMID 15008856  0.136
2021 Lulla AR, Akli S, Karakas C, Ha MJ, Fowlkes NW, Mitani Y, Bui T, Wang J, Rao X, Hunt KK, Meijer L, El-Naggar AK, Keyomarsi K. LMW cyclin E and its novel catalytic partner CDK5 are therapeutic targets and prognostic biomarkers in salivary gland cancers. Oncogenesis. 10: 40. PMID 33990543 DOI: 10.1038/s41389-021-00324-z  0.135
2019 Rubenstein R, Sharma DR, Chang B, Oumata N, Cam M, Vaucelle L, Lindberg MF, Chiu A, Wisniewski T, Wang KKW, Meijer L. Novel Mouse Tauopathy Model for Repetitive Mild Traumatic Brain Injury: Evaluation of Long-Term Effects on Cognition and Biomarker Levels After Therapeutic Inhibition of Tau Phosphorylation. Frontiers in Neurology. 10: 124. PMID 30915013 DOI: 10.3389/Fneur.2019.00124  0.133
2016 Meijer L, Nelson DJ, Riazanski V, Gabdoulkhakova AG, Hery-Arnaud G, Le Berre R, Loaëc N, Oumata N, Galons H, Nowak E, Gueganton L, Dorothée G, Prochazkova M, Hall B, Kulkarni AB, et al. Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis. Journal of Innate Immunity. PMID 26987072 DOI: 10.1159/000444256  0.132
2009 Epping MT, Meijer LA, Bos JL, Bernards R. UNC45A confers resistance to histone deacetylase inhibitors and retinoic acid. Molecular Cancer Research : McR. 7: 1861-70. PMID 19843631 DOI: 10.1158/1541-7786.Mcr-09-0187  0.129
2019 Esposito G, Mai LH, Longeon A, Mangoni A, Durieu E, Meijer L, Van Soest R, Costantino V, Bourguet-Kondracki ML. A Collection of Bioactive Nitrogen-Containing Molecules from the Marine Sponge . Marine Drugs. 17. PMID 31443260 DOI: 10.3390/md17080472  0.125
2013 Sallam H, El-Serafi I, Meijer L, Hassan M. Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice. Bmc Pharmacology & Toxicology. 14: 50. PMID 24079553 DOI: 10.1186/2050-6511-14-50  0.125
2005 Xie X, Lemcke T, Gussio R, Zaharevitz DW, Leost M, Meijer L, Kunick C. Epoxide-containing side chains enhance antiproliferative activity of paullones. European Journal of Medicinal Chemistry. 40: 655-61. PMID 15935900 DOI: 10.1016/j.ejmech.2005.02.004  0.121
1992 Azzi L, Meijer L, Reed SI, Pidikiti R, Tung HY. Interaction between the cell-cycle-control proteins p34cdc2 and p9CKShs2. Evidence for two cooperative binding domains in p9CKShs2. European Journal of Biochemistry / Febs. 203: 353-60. PMID 1310466 DOI: 10.1111/J.1432-1033.1992.TB16557.X  0.121
2024 Carey-Smith SL, Simad MH, Panchal K, Aya-Bonilla C, Smolders H, Lin S, Armitage JD, Nguyen VT, Bentley K, Ford J, Singh S, Oommen J, Laurent AP, Mercher T, Crispino JD, ... ... Meijer L, et al. Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia. Haematologica. PMID 38426275 DOI: 10.3324/haematol.2023.284271  0.12
2008 Ribas J, Yuste VJ, Garrofé-Ochoa X, Meijer L, Esquerda JE, Boix J. 7-Bromoindirubin-3'-oxime uncovers a serine protease-mediated paradigm of necrotic cell death. Biochemical Pharmacology. 76: 39-52. PMID 18485331 DOI: 10.1016/j.bcp.2008.03.023  0.119
2015 Harms H, Kehraus S, Nesaei-Mosaferan D, Hufendieck P, Meijer L, König GM. Aβ-42 lowering agents from the marine-derived fungus Dichotomomyces cejpii. Steroids. PMID 26440473 DOI: 10.1016/j.steroids.2015.09.012  0.116
2005 Laronze M, Boisbrun M, Léonce S, Pfeiffer B, Renard P, Lozach O, Meijer L, Lansiaux A, Bailly C, Sapi J, Laronze JY. Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-beta-carbolines. Bioorganic & Medicinal Chemistry. 13: 2263-83. PMID 15830466  0.115
2019 Vauthier V, Ben Saad A, Elie J, Oumata N, Durand-Schneider AM, Bruneau A, Delaunay JL, Housset C, Aït-Slimane T, Meijer L, Falguières T. Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models. Scientific Reports. 9: 6653. PMID 31040306 DOI: 10.1038/s41598-019-43111-y  0.113
2018 Nguyen TL, Duchon A, Manousopoulou A, Loaëc N, Villiers B, Pani G, Karatas M, Mechling AE, Harsan LA, Limanton E, Bazureau JP, Carreaux F, Garbis SD, Meijer L, Herault Y. Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A. Disease Models & Mechanisms. PMID 30115750 DOI: 10.1242/Dmm.035634  0.113
2014 Burgy G, Limanton E, Carreaux F, Durieu E, Meijer L, Bazureaua JP. Exploring the synthesis of new 1-(4-substitutedphenylamino) imidazo[1,5-a]indol-3-one derivatives as cyclized analogs of leucettines Journal of Applied Pharmaceutical Science. 4: 025-032. DOI: 10.7324/JAPS.2014.40604  0.111
2019 Hata S, Omori C, Kimura A, Saito H, Kimura N, Gupta V, Pedrini S, Hone E, Chatterjee P, Taddei K, Kasuga K, Ikeuchi T, Waragai M, Nishimura M, Hu A, ... ... Meijer L, et al. Decrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.). 5: 740-750. PMID 31754625 DOI: 10.1016/J.Trci.2019.09.015  0.109
2011 Epping MT, Meijer LA, Krijgsman O, Bos JL, Pandolfi PP, Bernards R. TSPYL5 suppresses p53 levels and function by physical interaction with USP7. Nature Cell Biology. 13: 102-8. PMID 21170034 DOI: 10.1038/Ncb2142  0.105
2020 Leven C, Schutz S, Audrezet MP, Nowak E, Meijer L, Montier T. Non-Linear Pharmacokinetics of Oral Roscovitine (Seliciclib) in Cystic Fibrosis Patients Chronically Infected with : A Study on Population Pharmacokinetics with Monte Carlo Simulations. Pharmaceutics. 12. PMID 33198319 DOI: 10.3390/pharmaceutics12111087  0.103
2009 Wingate H, Puskas A, Duong M, Bui T, Richardson D, Liu Y, Tucker SL, Van Pelt C, Meijer L, Hunt K, Keyomarsi K. Low molecular weight cyclin E is specific in breast cancer and is associated with mechanisms of tumor progression. Cell Cycle (Georgetown, Tex.). 8: 1062-8. PMID 19305161 DOI: 10.4161/Cc.8.7.8119  0.102
2015 Riazanski V, Gabdoulkhakova AG, Boynton LS, Eguchi RR, Deriy LV, Hogarth DK, Loaëc N, Oumata N, Galons H, Brown ME, Shevchenko P, Gallan AJ, Yoo SG, Naren AP, Villereal ML, ... ... Meijer L, et al. TRPC6 channel translocation into phagosomal membrane augments phagosomal function. Proceedings of the National Academy of Sciences of the United States of America. 112: E6486-95. PMID 26604306 DOI: 10.1073/Pnas.1518966112  0.099
2016 Portelius E, Durieu E, Bodin M, Cam M, Pannee J, Leuxe C, Mabondzo A, Oumata N, Galons H, Lee JY, Chang YT, Stϋber K, Koch P, Fontaine G, Potier MC, ... ... Meijer L, et al. Specific Triazine Herbicides Induce Amyloid-β42 Production. Journal of Alzheimer's Disease : Jad. PMID 27589520 DOI: 10.3233/Jad-160310  0.099
2006 Ribas J, Boix J, Meijer L. (R)-roscovitine (CYC202, Seliciclib) sensitizes SH-SY5Y neuroblastoma cells to nutlin-3-induced apoptosis. Experimental Cell Research. 312: 2394-400. PMID 16765943 DOI: 10.1016/j.yexcr.2006.04.021  0.096
2014 Da Silva PP, Bendjeddou LZ, Meijer L. [Search for natural substances with therapeutic activity: George R. Pettit]. Mã©Decine Sciences : M/S. 30: 319-28. PMID 24685224 DOI: 10.1051/medsci/20143003021  0.095
2018 Cam M, Durieu E, Bodin M, Manousopoulou A, Koslowski S, Vasylieva N, Barnych B, Hammock BD, Bohl B, Koch P, Omori C, Yamamoto K, Hata S, Suzuki T, Karg F, ... ... Meijer L, et al. Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides. Journal of Alzheimer's Disease : Jad. PMID 29504531 DOI: 10.3233/Jad-170875  0.091
1999 Spiik AK, Meijer LK, Ridderstad A, Pettersson S. Interference of eukaryotic signalling pathways by the bacteria Yersinia outer protein YopJ. Immunology Letters. 68: 199-203. PMID 10424421  0.09
2015 Hansen MM, Meijer LH, Spruijt E, Maas RJ, Rosquelles MV, Groen J, Heus HA, Huck WT. Macromolecular crowding creates heterogeneous environments of gene expression in picolitre droplets. Nature Nanotechnology. PMID 26501750 DOI: 10.1038/Nnano.2015.243  0.089
2011 Bourahla K, Paquin L, Lozach O, Meijer L, Carreaux F, Bazureau JP. A practical approach to new (5Z) 2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives. Molecules (Basel, Switzerland). 16: 7377-90. PMID 21878858 DOI: 10.3390/molecules16097377  0.088
1993 Monsees T, Meijer L, Jastorff B. 8-Dimethylamino-1-methyladenine, a novel potent antagonist of the 1-methyladenine receptor in starfish oocytes. European Journal of Biochemistry / Febs. 213: 155-65. PMID 8477690  0.088
2003 de Jong RN, Meijer LA, van der Vliet PC. DNA binding properties of the adenovirus DNA replication priming protein pTP. Nucleic Acids Research. 31: 3274-86. PMID 12799455 DOI: 10.1093/nar/gkg405  0.087
2015 van Roekel HW, Meijer LH, Masroor S, Félix Garza ZC, Estévez-Torres A, Rondelez Y, Zagaris A, Peletier MA, Hilbers PA, de Greef TF. Automated Design of Programmable Enzyme-Driven DNA Circuits. Acs Synthetic Biology. 4: 735-45. PMID 25365785 DOI: 10.1021/Sb500300D  0.085
2002 de Jong RN, Mysiak ME, Meijer LA, van der Linden M, van der Vliet PC. Recruitment of the priming protein pTP and DNA binding occur by overlapping Oct-1 POU homeodomain surfaces. The Embo Journal. 21: 725-35. PMID 11847120 DOI: 10.1093/emboj/21.4.725  0.085
2020 Koslowski S, Latapy C, Auvray P, Blondel M, Meijer L. An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts to Mini-Pigs. International Journal of Molecular Sciences. 21. PMID 32630605 DOI: 10.3390/ijms21124537  0.082
2010 Carpio L, Klase Z, Coley W, Guendel I, Choi S, Van Duyne R, Narayanan A, Kehn-Hall K, Meijer L, Kashanchi F. Erratum to: microRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection. Journal of Rnai and Gene Silencing : An International Journal of Rna and Gene Targeting Research. 6: E386. PMID 20963190  0.081
2012 Guihéneuf S, Paquin L, Carreaux F, Durieu E, Meijer L, Bazureau JP. An efficient approach to dispacamide A and its derivatives. Organic & Biomolecular Chemistry. 10: 978-87. PMID 22159215 DOI: 10.1039/c1ob06161e  0.08
2011 Safer A, Rahmouni M, Carreaux F, Paquin L, Lozach O, Meijer L, Bazureau JP. An expeditious, environment-friendly, and microwave-assisted synthesis of 5-isatinylidenerhodanine derivatives Chemical Papers. 65: 332-337. DOI: 10.2478/s11696-010-0104-9  0.08
2014 Li Y, Teo WL, Low MJ, Meijer L, Sanderson I, Pettersson S, Greicius G. Constitutive TLR4 signalling in intestinal epithelium reduces tumor load by increasing apoptosis in APC(Min/+) mice. Oncogene. 33: 369-77. PMID 23318418 DOI: 10.1038/onc.2012.581  0.079
2015 van Roekel HW, Rosier BJ, Meijer LH, Hilbers PA, Markvoort AJ, Huck WT, de Greef TF. Programmable chemical reaction networks: emulating regulatory functions in living cells using a bottom-up approach. Chemical Society Reviews. PMID 26214155 DOI: 10.1039/C5Cs00361J  0.078
2020 Guyot AC, Leuxe C, Disdier C, Oumata N, Costa N, Le Roux G, Varela PF, Duchon A, Charbonnier JB, Herault Y, Pavoni S, Galons H, Andriambeloson E, Wagner S, Meijer L, et al. Author Correction: A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment. Scientific Reports. 10: 10983. PMID 32620926 DOI: 10.1038/s41598-020-67127-x  0.073
2020 Koslowski S, Latapy C, Auvray P, Blondel M, Meijer L. Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice. International Journal of Environmental Research and Public Health. 17. PMID 32121376 DOI: 10.3390/ijerph17051579  0.073
2012 Ibrahim M, Blaise E, Lozach O, Szalata C, Schmitt M, El-Etrawy AAS, Elagawany M, El-Feky S, Abdel-Samii Z, Meijer L, Bourguignon JJ, Bihel F. Palladium-catalyzed synthesis of substituted pyrido[2,3- D ]pyridazines at positions 5 and 8 Synthesis (Germany). 44: 3216-3224. DOI: 10.1055/s-0032-1317145  0.066
2014 Norez C, Vandebrouck C, Bertrand J, Noel S, Durieu E, Oumata N, Galons H, Antigny F, Chatelier A, Bois P, Meijer L, Becq F. Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism. British Journal of Pharmacology. 171: 4831-49. PMID 25065395 DOI: 10.1111/bph.12859  0.065
2002 Bäckhed F, Meijer L, Normark S, Richter-Dahlfors A. TLR4-dependent recognition of lipopolysaccharide by epithelial cells requires sCD14. Cellular Microbiology. 4: 493-501. PMID 12174084  0.062
2001 Naik S, Kelly EJ, Meijer L, Pettersson S, Sanderson IR. Absence of Toll-like receptor 4 explains endotoxin hyporesponsiveness in human intestinal epithelium. Journal of Pediatric Gastroenterology and Nutrition. 32: 449-53. PMID 11396812 DOI: 10.1097/00005176-200104000-00011  0.061
2017 Marteyn BS, Burgel PR, Meijer L, Witko-Sarsat V. Harnessing Neutrophil Survival Mechanisms during Chronic Infection by Pseudomonas aeruginosa: Novel Therapeutic Targets to Dampen Inflammation in Cystic Fibrosis. Frontiers in Cellular and Infection Microbiology. 7: 243. PMID 28713772 DOI: 10.3389/Fcimb.2017.00243  0.06
2020 Shrestha CL, Zhang S, Wisniewski B, Häfner S, Elie J, Meijer L, Kopp BT. (R)-Roscovitine and CFTR modulators enhance killing of multi-drug resistant Burkholderia cenocepacia by cystic fibrosis macrophages. Scientific Reports. 10: 21700. PMID 33303916 DOI: 10.1038/s41598-020-78817-x  0.06
2005 Donald RG, Zhong T, Meijer L, Liberator PA. Characterization of two T. gondii CK1 isoforms. Molecular and Biochemical Parasitology. 141: 15-27. PMID 15811523 DOI: 10.1016/j.molbiopara.2005.01.011  0.059
2009 Debdab M, Renault S, Eid S, Lozach O, Meijer L, Carreaux F, Bazureau JP. An efficient method for the preparation of new analogs of leucettamine B under solvent-free microwave irradiation Heterocycles. 78: 1191-1203. DOI: 10.3987/COM-08-11594  0.059
2015 Cheng CY, Song J, Pas J, Meijer LH, Han S. DMSO induces dehydration near lipid membrane surfaces. Biophysical Journal. 109: 330-9. PMID 26200868 DOI: 10.1016/J.Bpj.2015.06.011  0.055
2004 Datson NA, Meijer L, Steenbergen PJ, Morsink MC, van der Laan S, Meijer OC, de Kloet ER. Expression profiling in laser-microdissected hippocampal subregions in rat brain reveals large subregion-specific differences in expression. The European Journal of Neuroscience. 20: 2541-54. PMID 15548198 DOI: 10.1111/J.1460-9568.2004.03738.X  0.053
1998 Cox GB, Walker RD, Freng SA, Short BA, Meijer L, Gilchrist L. Outcome of a controlled trial of the effectiveness of intensive case management for chronic public inebriates. Journal of Studies On Alcohol. 59: 523-32. PMID 9718104 DOI: 10.15288/Jsa.1998.59.523  0.047
2009 Oumata N, Ferandin Y, Meijer L, Galons H. Practical synthesis of roscovitine and CR8 Organic Process Research and Development. 13: 641-644. DOI: 10.1021/op800284k  0.046
2013 Vermetten E, Meijer L, van der Wurff P, Mert A. The effect of military motion-assisted memory desensitization and reprocessing treatment on the symptoms of combat-related post traumatic stress disorder: first preliminary results. Studies in Health Technology and Informatics. 191: 125-7. PMID 23792857 DOI: 10.3233/978-1-61499-282-0-125  0.045
2013 Demonty I, Ras RT, van der Knaap HC, Meijer L, Zock PL, Geleijnse JM, Trautwein EA. The effect of plant sterols on serum triglyceride concentrations is dependent on baseline concentrations: a pooled analysis of 12 randomised controlled trials. European Journal of Nutrition. 52: 153-60. PMID 22252793 DOI: 10.1007/s00394-011-0297-x  0.044
2003 van den Hoven R, Hierweck B, Dobretsberger M, Ensink JM, Meijer LA. Intramuscular dosing strategy for ampicillin sodium in horses, based on its distribution into tissue chambers before and after induction of inflammation. Journal of Veterinary Pharmacology and Therapeutics. 26: 405-11. PMID 14962051  0.04
2014 Heijblom M, Meijer LM, van Leeuwen TG, Steenbergen W, Manohar S. Monte Carlo simulations shed light on Bathsheba's suspect breast. Journal of Biophotonics. 7: 323-31. PMID 23225631 DOI: 10.1002/jbio.201200147  0.039
1993 Meijer LA, Ceyssens KG, de Jong WT, de Grève BI. Three phase elimination of oxytetracycline in veal calves; the presence of an extended terminal elimination phase. Journal of Veterinary Pharmacology and Therapeutics. 16: 214-22. PMID 8345571  0.038
2002 Boukes FS, Meijer LJ, Flikweert S, Assendelft WJ. [Summary of the standard "Vaginal bleeding" (first revision) of the Dutch College of General Practitioners]. Nederlands Tijdschrift Voor Geneeskunde. 146: 2179-83. PMID 12467159  0.038
2015 Cheng CY, Song J, Pas J, Meijer LHH, Han S. DMSO Induces Dehydration near Lipid Membrane Surfaces Biophysical Journal. 109: 330-339. DOI: 10.1016/j.bpj.2015.06.011  0.032
1991 Brash AR, Hughes MA, Hawkins DJ, Boeglin WE, Song WC, Meijer L. Allene oxide and aldehyde biosynthesis in starfish oocytes. The Journal of Biological Chemistry. 266: 22926-31. PMID 1744085  0.029
1993 Meijer LA, Ceyssens KG, de Grève BI, de Bruijn W. Pharmacokinetics and bioavailability of doxycycline hyclate after oral administration in calves. The Veterinary Quarterly. 15: 1-5. PMID 8498009 DOI: 10.1080/01652176.1993.9694358  0.029
1997 Zwart S, Meijer LJ. Oral contraceptives are drug of choice for menorrhagia in the Netherlands. Bmj (Clinical Research Ed.). 314: 75. PMID 9001504  0.029
2013 Meijer LJ, Schellevis FG. Referring patients with chronic kidney damage: Differences in referral criteria between hospitals | Verwijzing van patiënten met chronische nierschade: Verschillen in verwijscriteria tussen ziekenhuizen Nederlands Tijdschrift Voor Geneeskunde. 157.  0.029
2015 Le Large TY, Meijer LL, Mato Prado M, Kazemier G, Frampton AE, Giovannetti E. Circulating microRNAs as diagnostic biomarkers for pancreatic cancer. Expert Review of Molecular Diagnostics. 1-5. PMID 26567751 DOI: 10.1586/14737159.2015.1112273  0.028
2005 Smit BA, van Hylckama Vlieg JE, Engels WJ, Meijer L, Wouters JT, Smit G. Identification, cloning, and characterization of a Lactococcus lactis branched-chain alpha-keto acid decarboxylase involved in flavor formation. Applied and Environmental Microbiology. 71: 303-11. PMID 15640202 DOI: 10.1128/AEM.71.1.303-311.2005  0.028
2002 van Duijkeren E, Ensink JM, Meijer LA. Distribution of orally administered trimethoprim and sulfadiazine into noninfected subcutaneous tissue chambers in adult ponies. Journal of Veterinary Pharmacology and Therapeutics. 25: 273-7. PMID 12213115  0.026
2011 Oosterman JM, Morel S, Meijer L, Buvens C, Kessels RP, Postma A. Differential age effects on spatial and visual working memory. International Journal of Aging & Human Development. 73: 195-208. PMID 22272505 DOI: 10.2190/AG.73.3.a  0.025
2014 Rodriguez Gutierrez D, Awwad A, Meijer L, Manita M, Jaspan T, Dineen RA, Grundy RG, Auer DP. Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors. Ajnr. American Journal of Neuroradiology. 35: 1009-15. PMID 24309122 DOI: 10.3174/Ajnr.A3784  0.025
2014 Meijer L. Regional collaboration of general practitioners and specialists | Regionale samenwerking huisartsen en specialisten Huisarts En Wetenschap. 57: 602-603.  0.024
1993 Meijer LA, Ceyssens KG, de Jong WT, de Grève BI. Correlation between tissue and plasma concentrations of oxytetracycline in veal calves. Journal of Toxicology and Environmental Health. 40: 35-45. PMID 8360941 DOI: 10.1080/15287399309531774  0.024
2008 Meijer L, Weiss J, Van Velzen M, Brouwer A, Bergman A, Sauer PJ. Serum concentrations of neutral and phenolic organohalogens in pregnant women and some of their infants in The Netherlands. Environmental Science & Technology. 42: 3428-33. PMID 18522129  0.022
2012 Meijer L, Martijn A, Melessen J, Brouwer A, Weiss J, de Jong FH, Sauer PJ. Influence of prenatal organohalogen levels on infant male sexual development: sex hormone levels, testes volume and penile length. Human Reproduction (Oxford, England). 27: 867-72. PMID 22215630 DOI: 10.1093/humrep/der426  0.018
2009 Demonty I, Ras RT, van der Knaap HC, Duchateau GS, Meijer L, Zock PL, Geleijnse JM, Trautwein EA. Continuous dose-response relationship of the LDL-cholesterol-lowering effect of phytosterol intake. The Journal of Nutrition. 139: 271-84. PMID 19091798 DOI: 10.3945/jn.108.095125  0.018
2015 de Vries CJ, Meijer LJ, Janssen CA, Burgers JS, Opstelten W. [Dutch College of General Practitioners' practice guideline on 'Vaginal bleeding']. Nederlands Tijdschrift Voor Geneeskunde. 159: A8534. PMID 25654687  0.018
2004 Meijer LA, Verstegen JC, Bull S, Fink-Gremmels J. Metabolism of bromhexine in pig hepatocyte cultures. Journal of Veterinary Pharmacology and Therapeutics. 27: 219-25. PMID 15305850 DOI: 10.1111/j.1365-2885.2004.00584.x  0.017
1999 Lequin MH, van Rijn RR, Robben SG, Hop WC, Dijkhuis S, Fijten MM, Meijer LA, van Kuijk C. Evaluation of short-term precision for tibial ultrasonometry. Calcified Tissue International. 64: 24-7. PMID 9868279  0.016
2006 Meijer L, Hafkamp AM, Bosman WE, Havinga R, Bergman A, Sauer PJ, Verkade HJ. Nonabsorbable dietary fat enhances disposal of 2,2',4,4'-tetrabromodiphenyl ether in rats through interruption of enterohepatic circulation. Journal of Agricultural and Food Chemistry. 54: 6440-4. PMID 16910742 DOI: 10.1021/jf0608827  0.014
2014 Nyenje PM, Meijer LMG, Foppen JW, Kulabako R, Uhlenbrook S. Phosphorus transport and retention in a channel draining an urban, tropical catchment with informal settlements Hydrology and Earth System Sciences. 18: 1009-1025. DOI: 10.5194/hess-18-1009-2014  0.013
2009 Roze E, Meijer L, Bakker A, Van Braeckel KN, Sauer PJ, Bos AF. Prenatal exposure to organohalogens, including brominated flame retardants, influences motor, cognitive, and behavioral performance at school age. Environmental Health Perspectives. 117: 1953-8. PMID 20049217 DOI: 10.1289/ehp.0901015  0.011
2012 Meijer LJ, Schellevis F. [Referring patients with chronic renal failure: differences in referral criteria between hospitals]. Nederlands Tijdschrift Voor Geneeskunde. 156: A5259. PMID 23231873  0.011
2013 van Ark M, van den Akker-Scheek I, Meijer LT, Zwerver J. An exercise-based physical therapy program for patients with patellar tendinopathy after platelet-rich plasma injection. Physical Therapy in Sport : Official Journal of the Association of Chartered Physiotherapists in Sports Medicine. 14: 124-30. PMID 23010772 DOI: 10.1016/j.ptsp.2012.05.002  0.01
2015 Le Large TY, Frampton AE, Meijer LL, Stebbing J, Kazemier G, Giovannetti E. Usefulness of Measuring microRNAs in Bile and Plasma for Pancreatic Ductal Adenocarcinoma Diagnosis. The American Journal of Gastroenterology. 110: 768-9. PMID 25942302 DOI: 10.1038/ajg.2015.77  0.01
2014 Meijer LTB, van Raaij TM, Zwerver J. A 17-year-old judoka with acute hip pain International Sportmed Journal. 15: 310-314.  0.01
2010 Roze E, Meijer L, Van Braeckel KN, Ruiter SA, Bruggink JL, Bos AF. Developmental trajectories from birth to school age in healthy term-born children. Pediatrics. 126: e1134-42. PMID 20921067 DOI: 10.1542/peds.2010-0698  0.01
2009 Sobanko JF, Meijer L, Nigra TP. Epithelioid sarcoma: a review and update. The Journal of Clinical and Aesthetic Dermatology. 2: 49-54. PMID 20729965  0.01
2002 Wiersma TJ, Assendelft WJ, Meijer LJ, Verhoeven S. [Treatment of patients with a TIA or a stroke]. Nederlands Tijdschrift Voor Geneeskunde. 146: 2384-5; author reply. PMID 12510406  0.01
2001 van Wuijckhuise L, Frankena K, van Oijen MA, Meijer L. [Analysis of symptoms associated with bovine herpesvirus 1 vaccination]. Tijdschrift Voor Diergeneeskunde. 126: 173-80. PMID 11285635  0.01
1993 Henkens K, Meijer L, Siegers J. The labour supply of married and cohabiting women in the Netherlands, 1981-1989. European Journal of Population = Revue Europã©Enne De Dã©Mographie. 9: 331-52. PMID 12345354  0.01
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