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Mary Jo LaDu - Publications

Affiliations: 
University of Illinois at Chicago, Chicago, IL, United States 
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48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Valencia-Olvera AC, Balu D, Moore A, Shah M, Ainis R, Xiang B, Saleh Y, Cai D, LaDu MJ, Tai LM. APOE2 Heterozygosity Reduces Hippocampal Soluble Amyloid-β42 Levels in Non-Hyperlipidemic Mice. Journal of Alzheimer's Disease : Jad. PMID 38306049 DOI: 10.3233/JAD-231210  0.403
2023 Valencia-Olvera AC, Balu D, Bellur S, McNally T, Saleh Y, Pham D, Ghura S, York J, Johansson JO, LaDu MJ, Tai L. A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3. Alzheimer's Research & Therapy. 15: 216. PMID 38102668 DOI: 10.1186/s13195-023-01353-z  0.42
2023 Balu D, Valencia-Olvera AC, Islam Z, Mielczarek C, Hansen A, Perez Ramos TM, York J, LaDu MJ, Tai LM. genotype and sex modulate Alzheimer's disease pathology in aged EFAD transgenic mice. Frontiers in Aging Neuroscience. 15: 1279343. PMID 38020764 DOI: 10.3389/fnagi.2023.1279343  0.44
2023 Balu D, Valencia-Olvera AC, Nguyen A, Patnam M, York J, Peri F, Neumann F, LaDu MJ, Tai LM. A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice. Alzheimer's Research & Therapy. 15: 181. PMID 37858252 DOI: 10.1186/s13195-023-01330-6  0.427
2023 Valencia-Olvera AC, Balu D, Faulk N, Amiridis A, Wang Y, Pham C, Avila-Munoz E, York JM, Thatcher GRJ, LaDu MJ. Inhibition of ACAT as a Therapeutic Target for Alzheimer's Disease Is Independent of ApoE4 Lipidation. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 37157042 DOI: 10.1007/s13311-023-01375-3  0.406
2022 Valencia-Olvera AC, Maldonado Weng J, Christensen A, LaDu MJ, Pike CJ. Role of estrogen in women's Alzheimer's disease risk as modified by APOE. Journal of Neuroendocrinology. e13209. PMID 36420620 DOI: 10.1111/jne.13209  0.362
2022 Rangan P, Lobo F, Parrella E, Rochette N, Morselli M, Stephen TL, Cremonini AL, Tagliafico L, Persia A, Caffa I, Monacelli F, Odetti P, Bonfiglio T, Nencioni A, Pigliautile M, ... ... LaDu MJ, et al. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Cell Reports. 40: 111417. PMID 36170815 DOI: 10.1016/j.celrep.2022.111417  0.33
2022 Taxier LR, Philippi SM, Fleischer AW, York JM, LaDu MJ, Frick KM. APOE4 homozygote females are resistant to the beneficial effects of 17β-estradiol on memory and CA1 dendritic spine density in the EFAD mouse model of Alzheimer's disease. Neurobiology of Aging. 118: 13-24. PMID 35843109 DOI: 10.1016/j.neurobiolaging.2022.06.005  0.521
2022 Taxier LR, Philippi SM, York JM, LaDu MJ, Frick KM. APOE4 genotype or ovarian hormone loss influence open field exploration in an EFAD mouse model of Alzheimer's disease. Hormones and Behavior. 140: 105124. PMID 35101701 DOI: 10.1016/j.yhbeh.2022.105124  0.512
2021 Taxier LR, Philippi SM, York JM, LaDu MJ, Frick KM. The detrimental effects of APOE4 on risk for Alzheimer's disease may result from altered dendritic spine density, synaptic proteins, and estrogen receptor alpha. Neurobiology of Aging. 112: 74-86. PMID 35051676 DOI: 10.1016/j.neurobiolaging.2021.12.006  0.542
2020 Parikh IJ, Estus JL, Zajac DJ, Malik M, Maldonado Weng J, Tai LM, Chlipala GE, LaDu MJ, Green SJ, Estus S. Murine Gut Microbiome Association With Alleles. Frontiers in Immunology. 11: 200. PMID 32117315 DOI: 10.3389/Fimmu.2020.00200  0.363
2020 Lewandowski CT, Weng JM, LaDu MJ. Alzheimer's disease pathology in ApoE transgenic mouse models: The Who, What, When, Where, Why, and How. Neurobiology of Disease. 104811. PMID 32087290 DOI: 10.1016/j.nbd.2020.104811  0.317
2019 Maldonado Weng J, Parikh I, Naqib A, York J, Green SJ, Estus S, LaDu MJ. Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice. Molecular Neurodegeneration. 14: 47. PMID 31861986 DOI: 10.1186/S13024-019-0352-2  0.443
2019 Balu D, Karstens AJ, Loukenas E, Maldonado Weng J, Valencia-Olvera AC, LaDu MJ. The role of APOE in transgenic mouse models of AD. Neuroscience Letters. 134285. PMID 31150730 DOI: 10.1016/j.neulet.2019.134285  0.42
2017 Tai LM, Balu D, Avila-Munoz E, Abdullah L, Thomas R, Collins N, Valencia-Olvera AC, LaDu MJ. EFAD Transgenic Mice as a Human APOE Relevant Preclinical Model of Alzheimer's Disease. Journal of Lipid Research. PMID 28389477 DOI: 10.1194/jlr.R076315  0.404
2016 Ghura S, Tai L, Zhao M, Collins N, Che CT, Warpeha KM, LaDu MJ. Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer's disease in vitro. Scientific Reports. 6: 29364. PMID 27383500 DOI: 10.1038/srep29364  0.389
2016 Koster KP, Smith C, Valencia-Olvera AC, Thatcher GR, LaDu MJ, Tai LM. Rexinoids as therapeutics for Alzheimer disease: Role of APOE. Current Topics in Medicinal Chemistry. PMID 27320328  0.387
2016 Teter B, LaDu MJ, Sullivan PM, Frautschy SA, Cole GM. Apolipoprotein ε isotype-dependent modulation of microRNA-146a in plasma and brain. Neuroreport. PMID 27281274 DOI: 10.1097/WNR.0000000000000608  0.307
2016 Luo J, Lee SH, VandeVrede L, Qin Z, Ben Aissa M, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR. A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease. Molecular Neurodegeneration. 11: 35. PMID 27129593 DOI: 10.1186/S13024-016-0103-6  0.318
2016 Zhou M, Huang T, Collins N, Zhang J, Shen H, Dai X, Xiao N, Wu X, Wei Z, York J, Lin L, Zhu Y, LaDu MJ, Chen X. APOE4 induces site-specific tau phosphorylation through calpain-CDK5 signaling pathway in EFAD-Tg mice. Current Alzheimer Research. PMID 27087442 DOI: 10.2174/1567205013666160415154550  0.345
2016 Cacciottolo M, Christensen A, Moser A, Liu J, Pike CJ, Smith C, LaDu MJ, Sullivan PM, Morgan TE, Dolzhenko E, Charidimou A, Wahlund LO, Wiberg MK, Shams S, Chiang GC, et al. The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice. Neurobiology of Aging. 37: 47-57. PMID 26686669 DOI: 10.1016/J.Neurobiolaging.2015.10.010  0.402
2015 Malik M, Parikh I, Vasquez JB, Smith C, Tai L, Bu G, LaDu MJ, Fardo DW, Rebeck GW, Estus S. Genetics ignite focus on microglial inflammation in Alzheimer's disease. Molecular Neurodegeneration. 10: 52. PMID 26438529 DOI: 10.1186/S13024-015-0048-1  0.317
2015 Liu DS, Pan XD, Zhang J, Shen H, Collins NC, Cole AM, Koster KP, Ben Aissa M, Dai XM, Zhou M, Tai LM, Zhu YG, LaDu M, Chen XC. APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice. Molecular Neurodegeneration. 10: 7. PMID 25871877 DOI: 10.1186/s13024-015-0002-2  0.339
2015 Tai LM, Ghura S, Koster KP, Liakaite V, Maienschein-Cline M, Kanabar P, Collins N, Ben-Aissa M, Lei AZ, Bahroos N, Green SJ, Hendrickson B, Van Eldik LJ, LaDu MJ. APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective. Journal of Neurochemistry. 133: 465-88. PMID 25689586 DOI: 10.1111/jnc.13072  0.322
2014 Tai LM, Koster KP, Luo J, Lee SH, Wang YT, Collins NC, Ben Aissa M, Thatcher GR, LaDu MJ. Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo. The Journal of Biological Chemistry. 289: 30538-55. PMID 25217640 DOI: 10.1074/jbc.M114.600833  0.394
2014 Rodriguez GA, Tai LM, LaDu MJ, Rebeck GW. Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition. Journal of Neuroinflammation. 11: 111. PMID 24948358 DOI: 10.1186/1742-2094-11-111  0.437
2014 Tai LM, Mehra S, Shete V, Estus S, Rebeck GW, Bu G, LaDu MJ. Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk. Molecular Neurodegeneration. 9: 2. PMID 24386905 DOI: 10.1186/1750-1326-9-2  0.394
2014 Nwabuisi-Heath E, Rebeck GW, Ladu MJ, Yu C. ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro. Asn Neuro. 6: e00134. PMID 24328732 DOI: 10.1042/AN20130043  0.356
2013 Wolf AB, Valla J, Bu G, Kim J, LaDu MJ, Reiman EM, Caselli RJ. Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease. Alzheimer's Research & Therapy. 5: 38. PMID 23998393 DOI: 10.1186/Alzrt204  0.343
2013 Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV, Van Eldik LJ, Fardo DW, Estus S, Bu G, Gylys KH, ... Ladu MJ, et al. Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. The Journal of Biological Chemistry. 288: 5914-26. PMID 23293020 DOI: 10.1074/Jbc.M112.442103  0.4
2012 Li J, Kanekiyo T, Shinohara M, Zhang Y, LaDu MJ, Xu H, Bu G. Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms. The Journal of Biological Chemistry. 287: 44593-601. PMID 23132858 DOI: 10.1074/Jbc.M112.420224  0.324
2012 Youmans KL, Tai LM, Nwabuisi-Heath E, Jungbauer L, Kanekiyo T, Gan M, Kim J, Eimer WA, Estus S, Rebeck GW, Weeber EJ, Bu G, Yu C, Ladu MJ. APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. The Journal of Biological Chemistry. 287: 41774-86. PMID 23060451 DOI: 10.1074/Jbc.M112.407957  0.38
2012 Zhu Y, Nwabuisi-Heath E, Dumanis SB, Tai LM, Yu C, Rebeck GW, LaDu MJ. APOE genotype alters glial activation and loss of synaptic markers in mice. Glia. 60: 559-69. PMID 22228589 DOI: 10.1002/Glia.22289  0.336
2012 LaDu MJ, Munson GW, Jungbauer L, Getz GS, Reardon CA, Tai LM, Yu C. Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift. Biochimica Et Biophysica Acta. 1821: 295-302. PMID 22138302 DOI: 10.1016/J.Bbalip.2011.11.005  0.341
2011 Youmans KL, Leung S, Zhang J, Maus E, Baysac K, Bu G, Vassar R, Yu C, LaDu MJ. Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations. Journal of Neuroscience Methods. 196: 51-9. PMID 21219931 DOI: 10.1016/J.Jneumeth.2010.12.025  0.34
2010 Lewis TL, Cao D, Lu H, Mans RA, Su YR, Jungbauer L, Linton MF, Fazio S, LaDu MJ, Li L. Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease. The Journal of Biological Chemistry. 285: 36958-68. PMID 20847045 DOI: 10.1074/Jbc.M110.127829  0.39
2009 Dumanis SB, Tesoriero JA, Babus LW, Nguyen MT, Trotter JH, Ladu MJ, Weeber EJ, Turner RS, Xu B, Rebeck GW, Hoe HS. ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15317-22. PMID 19955384 DOI: 10.1523/Jneurosci.4026-09.2009  0.402
2007 Manelli AM, Bulfinch LC, Sullivan PM, LaDu MJ. Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation. Neurobiology of Aging. 28: 1139-47. PMID 16837105 DOI: 10.1016/j.neurobiolaging.2006.05.024  0.383
2006 Rebeck GW, LaDu MJ, Estus S, Bu G, Weeber EJ. The generation and function of soluble apoE receptors in the CNS. Molecular Neurodegeneration. 1: 15. PMID 17062143 DOI: 10.1186/1750-1326-1-15  0.347
2006 Yun SH, Gamkrelidze G, Stine WB, Sullivan PM, Pasternak JF, Ladu MJ, Trommer BL. Amyloid-beta1-42 reduces neuronal excitability in mouse dentate gyrus. Neuroscience Letters. 403: 162-5. PMID 16765515 DOI: 10.1016/j.neulet.2006.04.065  0.329
2005 White JA, Manelli AM, Holmberg KH, Van Eldik LJ, Ladu MJ. Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation. Neurobiology of Disease. 18: 459-65. PMID 15755672 DOI: 10.1016/j.nbd.2004.12.013  0.413
2005 Trommer BL, Shah C, Yun SH, Gamkrelidze G, Pasternak ES, Stine WB, Manelli A, Sullivan P, Pasternak JF, LaDu MJ. ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42. Neurobiology of Disease. 18: 75-82. PMID 15649697 DOI: 10.1016/J.Nbd.2004.08.011  0.416
2004 Trommer BL, Shah C, Yun SH, Gamkrelidze G, Pasternak ES, Ye GL, Sotak M, Sullivan PM, Pasternak JF, LaDu MJ. ApoE isoform affects LTP in human targeted replacement mice. Neuroreport. 15: 2655-8. PMID 15570172 DOI: 10.1097/00001756-200412030-00020  0.385
2004 Irizarry MC, Deng A, Lleo A, Berezovska O, Von Arnim CA, Martin-Rehrmann M, Manelli A, LaDu MJ, Hyman BT, Rebeck GW. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein. Journal of Neurochemistry. 90: 1132-43. PMID 15312168 DOI: 10.1111/J.1471-4159.2004.02581.X  0.337
2004 Manelli AM, Stine WB, Van Eldik LJ, LaDu MJ. ApoE and Abeta1-42 interactions: effects of isoform and conformation on structure and function. Journal of Molecular Neuroscience : Mn. 23: 235-46. PMID 15181252 DOI: 10.1385/JMN:23:3:235  0.342
2004 Guo L, LaDu MJ, Van Eldik LJ. A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity. Journal of Molecular Neuroscience : Mn. 23: 205-12. PMID 15181248 DOI: 10.1385/JMN:23:3:205  0.342
2000 Tokuda T, Calero M, Matsubara E, Vidal R, Kumar A, Permanne B, Zlokovic B, Smith JD, Ladu MJ, Rostagno A, Frangione B, Ghiso J. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. The Biochemical Journal. 348: 359-65. PMID 10816430 DOI: 10.1042/0264-6021:3480359  0.322
1996 Metzger RE, LaDu MJ, Pan JB, Getz GS, Frail DE, Falduto MT. Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: implications for Alzheimer's disease. Journal of Neuropathology and Experimental Neurology. 55: 372-80. PMID 8786396 DOI: 10.1097/00005072-199603000-00013  0.36
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