Krzysztof Palczewski - Publications

Affiliations: 
1997 Pharmacology University of Washington, Seattle, Seattle, WA 

363 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Choi EH, Suh S, Foik AT, Leinonen H, Newby GA, Gao XD, Banskota S, Hoang T, Du SW, Dong Z, Raguram A, Kohli S, Blackshaw S, Lyon DC, Liu DR, ... Palczewski K, et al. In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration. Nature Communications. 13: 1830. PMID 35383196 DOI: 10.1038/s41467-022-29490-3  0.828
2022 Banskota S, Raguram A, Suh S, Du SW, Davis JR, Choi EH, Wang X, Nielsen SC, Newby GA, Randolph PB, Osborn MJ, Musunuru K, Palczewski K, Liu DR. Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins. Cell. PMID 35021064 DOI: 10.1016/j.cell.2021.12.021  0.781
2022 Lewandowski D, Foik AT, Smidak R, Choi EH, Zhang J, Hoang T, Tworak A, Suh S, Leinonen H, Dong Z, Pinto AF, Tom E, Luu JC, Lee JY, Ma X, ... ... Palczewski K, et al. Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision. Jci Insight. PMID 35015730 DOI: 10.1172/jci.insight.156301  0.83
2022 Du SW, Palczewski K. MicroRNA regulation of critical retinal pigment epithelial functions. Trends in Neurosciences. 45: 78-90. PMID 34753606 DOI: 10.1016/j.tins.2021.10.008  0.328
2021 Getter T, Kemp A, Vinberg F, Palczewski K. Identification of small-molecule allosteric modulators that act as enhancers/disrupters of rhodopsin oligomerization. The Journal of Biological Chemistry. 297: 101401. PMID 34774799 DOI: 10.1016/j.jbc.2021.101401  0.309
2021 Occelli LM, Daruwalla A, De Silva SR, Winkler PA, Sun K, Pasmanter N, Minella A, Querubin J, Lyons LA, Consortium L, Robson AG, Heon E, Michaelides M, Webster AR, Palczewski K, et al. A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype. Human Molecular Genetics. PMID 34726233 DOI: 10.1093/hmg/ddab316  0.766
2021 Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD. Structural evidence for visual arrestin priming via complexation of phosphoinositols. Structure (London, England : 1993). PMID 34678158 DOI: 10.1016/j.str.2021.10.002  0.802
2021 Sander CL, Sears AE, Pinto AFM, Choi EH, Kahremany S, Gao F, Salom D, Jin H, Pardon E, Suh S, Dong Z, Steyaert J, Saghatelian A, Skowronska-Krawczyk D, Kiser PD, ... Palczewski K, et al. Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. The Journal of Cell Biology. 220. PMID 34132745 DOI: 10.1083/jcb.202101063  0.775
2021 Blum E, Zhang J, Zaluski J, Einstein DE, Korshin EE, Kubas A, Gruzman A, Tochtrop GP, Kiser PD, Palczewski K. Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. Journal of Medicinal Chemistry. PMID 34081480 DOI: 10.1021/acs.jmedchem.1c00279  0.791
2021 Leinonen H, Cheng C, Pitkänen M, Sander CL, Zhang J, Saeid S, Turunen T, Shmara A, Weiss L, Ta L, Ton T, Koskelainen A, Vargas JD, Kimonis V, Palczewski K. . The Journal of Pharmacology and Experimental Therapeutics. PMID 33931547 DOI: 10.1124/jpet.120.000486  0.759
2021 Choi EH, Suh S, Einstein DE, Leinonen H, Dong Z, Ramachandra Rao S, Fliesler SJ, Blackshaw S, Yu M, Peachey NS, Palczewski K, Kiser PD. An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease. Jci Insight. PMID 33784255 DOI: 10.1172/jci.insight.146604  0.818
2021 Yu G, Gao SQ, Dong Z, Sheng L, Sun D, Zhang N, Zhang J, Margeivicus S, Fu P, Golczak M, Maeda A, Palczewski K, Lu ZR. Peptide Derivatives of Retinylamine Prevent Retinal Degeneration with Minimal Side Effects on Vision in Mice. Bioconjugate Chemistry. PMID 33677964 DOI: 10.1021/acs.bioconjchem.1c00043  0.355
2021 Kolesnikov AV, Kiser PD, Palczewski K, Kefalov VJ. Function of mammalian M-cones depends on the level of CRALBP in Müller cells. The Journal of General Physiology. 153. PMID 33216847 DOI: 10.1085/jgp.202012675  0.8
2020 Kiser PD, Palczewski K. Pathways and disease-causing alterations in visual chromophore production for vertebrate vision. The Journal of Biological Chemistry. 296: 100072. PMID 33434742 DOI: 10.1074/jbc.REV120.014405  0.384
2020 Kiser PD, Palczewski K. Pathways and disease-causing alterations in visual chromophore production for vertebrate vision. The Journal of Biological Chemistry. PMID 33187985 DOI: 10.1074/jbc.REV120.014405  0.811
2020 Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nature Biomedical Engineering. PMID 33122854 DOI: 10.1038/s41551-020-00652-2  0.802
2020 Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nature Biomedical Engineering. PMID 33077938 DOI: 10.1038/s41551-020-00632-6  0.805
2020 Leinonen H, Pham NC, Boyd T, Santoso J, Palczewski K, Vinberg F. Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease. Elife. 9. PMID 32960171 DOI: 10.7554/Elife.59422  0.47
2020 Sears AE, Albiez S, Gulati S, Wang B, Kiser P, Kovacik L, Engel A, Stahlberg H, Palczewski K. Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32860273 DOI: 10.1096/Fj.202000796Rr  0.794
2020 Palczewska G, Boguslawski J, Stremplewski P, Kornaszewski L, Zhang J, Dong Z, Liang XX, Gratton E, Vogel A, Wojtkowski M, Palczewski K. Noninvasive two-photon optical biopsy of retinal fluorophores. Proceedings of the National Academy of Sciences of the United States of America. PMID 32848058 DOI: 10.1073/Pnas.2007527117  0.4
2020 Palczewski K, Kiser PD. Shedding new light on the generation of the visual chromophore. Proceedings of the National Academy of Sciences of the United States of America. PMID 32759209 DOI: 10.1073/pnas.2008211117  0.807
2020 Blum E, Zhang J, Korshin E, Palczewski K, Gruzman A. Development of chiral fluorinated alkyl derivatives of emixustat as drug candidates for the treatment of retinal degenerative diseases. Bioorganic & Medicinal Chemistry Letters. 30: 127421. PMID 32717613 DOI: 10.1016/J.Bmcl.2020.127421  0.469
2020 Luu J, Kallestad L, Hoang T, Lewandowski D, Dong Z, Blackshaw S, Palczewski K. Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model. Human Molecular Genetics. PMID 32691052 DOI: 10.1093/Hmg/Ddaa158  0.355
2020 Han X, Hofmann L, de la Fuente M, Alexander N, Palczewski K, Invent Consortium I, Nieman MT. PAR4 activation involves extracellular loop-3 and transmembrane residue Thr153. Blood. PMID 32575122 DOI: 10.1182/Blood.2019004634  0.313
2020 Choi EH, Daruwalla A, Suh S, Leinonen H, Palczewski K. Retinoids in the visual cycle: Role of the retinal G protein-coupled receptor. Journal of Lipid Research. PMID 32493732 DOI: 10.1194/Jlr.Tr120000850  0.839
2020 Corral-Serrano JC, Lamers IJC, van Reeuwijk J, Duijkers L, Hoogendoorn ADM, Yildirim A, Argyrou N, Ruigrok RAA, Letteboer SJF, Butcher R, van Essen MD, Sakami S, van Beersum SEC, Palczewski K, Cheetham ME, et al. PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation. Proceedings of the National Academy of Sciences of the United States of America. PMID 32312818 DOI: 10.1073/Pnas.1903125117  0.425
2019 Zhang J, Choi EH, Tworak A, Salom D, Leinonen H, Sander CL, Hoang TV, Handa JT, Blackshaw S, Palczewska G, Kiser PD, Palczewski K. Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. The Journal of Biological Chemistry. PMID 31694912 DOI: 10.1074/Jbc.Ra119.011169  0.833
2019 Kallestad L, Blackshaw S, Khalil AM, Palczewski K. Tissue- and Species-Specific Patterns of RNA metabolism in Post-Mortem Mammalian Retina and Retinal Pigment Epithelium. Scientific Reports. 9: 14821. PMID 31616038 DOI: 10.1038/S41598-019-51379-3  0.301
2019 Sun D, Schur RM, Sears AE, Gao SQ, Vaidya A, Sun W, Maeda A, Kern T, Palczewski K, Lu ZR. Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 31611143 DOI: 10.1016/J.Ymthe.2019.09.010  0.314
2019 Ruminski D, Palczewska G, Nowakowski M, Zielińska A, Kefalov VJ, Komar K, Palczewski K, Wojtkowski M. Two-photon microperimetry: sensitivity of human photoreceptors to infrared light. Biomedical Optics Express. 10: 4551-4567. PMID 31565509 DOI: 10.1364/Boe.10.004551  0.4
2019 Kahremany S, Sander CL, Tochtrop GP, Kubas A, Palczewski K. Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis. Organic & Biomolecular Chemistry. PMID 31455964 DOI: 10.1039/C9Ob01645G  0.72
2019 Vinberg F, Palczewska G, Zhang J, Komar K, Wojtkowski M, Kefalov VJ, Palczewski K. Sensitivity of Mammalian Cone Photoreceptors to Infrared Light. Neuroscience. PMID 31400484 DOI: 10.1016/J.Neuroscience.2019.07.047  0.368
2019 Zhao DY, Poege M, Morizumi T, Gulati S, Van Eps N, Zhang J, Miszta P, Filipek S, Mahamid J, Plitzko JM, Baumeister W, Ernst OP, Palczewski K. Cryo-EM structure of the native rhodopsin dimer in nanodiscs. The Journal of Biological Chemistry. PMID 31399513 DOI: 10.1074/Jbc.Ra119.010089  0.362
2019 Getter T, Gulati S, Zimmerman R, Chen Y, Vinberg F, Palczewski K. Stereospecific modulation of dimeric rhodopsin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900443RR. PMID 31121099 DOI: 10.1096/Fj.201900443Rr  0.499
2019 Getter T, Suh S, Hoang T, Handa JT, Dong Z, Ma X, Chen Y, Blackshaw S, Palczewski K. The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration. The Journal of Biological Chemistry. PMID 31073029 DOI: 10.1074/Jbc.Ra119.008697  0.588
2019 Liu H, Tang J, Du Y, Saadane A, Samuels I, Veenstra A, Kiser JZ, Palczewski K, Kern TS. Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy. Investigative Ophthalmology & Visual Science. 60: 1538-1546. PMID 30994864 DOI: 10.1167/Iovs.18-26433  0.346
2019 Salom D, Jin H, Gerken TA, Yu C, Huang L, Palczewski K. Human red and green cone opsins are O-glycosylated at an N-terminal Ser/Thr-rich domain conserved in vertebrates. The Journal of Biological Chemistry. PMID 30948514 DOI: 10.1074/Jbc.Ra118.006835  0.359
2019 Leinonen H, Choi EH, Gardella A, Kefalov VJ, Palczewski K. A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness. Investigative Ophthalmology & Visual Science. 60: 1442-1453. PMID 30947334 DOI: 10.1167/Iovs.19-26560  0.783
2019 Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L. Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases. Science Advances. 5: eaav4322. PMID 30820458 DOI: 10.1126/Sciadv.Aav4322  0.322
2019 Katayama K, Gulati S, Ortega JT, Alexander NS, Sun W, Shenouda MM, Palczewski K, Jastrzebska B. Specificity of the chromophore-binding site in human cone opsins. The Journal of Biological Chemistry. PMID 30770468 DOI: 10.1074/Jbc.Ra119.007587  0.479
2019 Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802493R. PMID 30645148 DOI: 10.1096/Fj.201802493R  0.818
2018 Sakami S, Imanishi Y, Palczewski K. Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201801662R. PMID 30462532 DOI: 10.1096/Fj.201801662R  0.719
2018 Sato S, Jastrzebska B, Engel A, Palczewski K, Kefalov VJ. Apo-opsin exists in equilibrium between a predominant inactive and a rare highly active state. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30459230 DOI: 10.1523/Jneurosci.1980-18.2018  0.406
2018 Daruwalla A, Choi EH, Palczewski K, Kiser PD. Structural biology of 11-retinaldehyde production in the classical visual cycle. The Biochemical Journal. 475: 3171-3188. PMID 30352831 DOI: 10.1042/Bcj20180193  0.805
2018 Behnen P, Felline A, Comitato A, Di Salvo MT, Raimondi F, Gulati S, Kahremany S, Palczewski K, Marigo V, Fanelli F. A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness. Iscience. 4: 1-19. PMID 30240733 DOI: 10.1016/J.Isci.2018.05.001  0.42
2018 Palczewska G, Stremplewski P, Suh S, Alexander N, Salom D, Dong Z, Ruminski D, Choi EH, Sears AE, Kern TS, Wojtkowski M, Palczewski K. Two-photon imaging of the mammalian retina with ultrafast pulsing laser. Jci Insight. 3. PMID 30185665 DOI: 10.1172/Jci.Insight.121555  0.786
2018 Gao S, Parmar T, Palczewska G, Dong Z, Golczak M, Palczewski K, Jastrzebska B. Protective effect of a locked retinal chromophore analogue against light-induced retinal degeneration. Molecular Pharmacology. PMID 30018116 DOI: 10.1124/Mol.118.112581  0.497
2018 Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nature Communications. 9: 1996. PMID 29777099 DOI: 10.1038/S41467-018-04432-0  0.766
2018 Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, ... ... Palczewski K, et al. A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nature Communications. 9: 1976. PMID 29773803 DOI: 10.1038/S41467-018-04261-1  0.599
2018 Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Human Molecular Genetics. PMID 29659842 DOI: 10.1093/Hmg/Ddy128  0.821
2018 Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K. Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. The Journal of General Physiology. PMID 29500274 DOI: 10.1085/Jgp.201711815  0.809
2018 Gao S, Kahremany S, Zhang J, Jastrzebska B, Querubin J, Petersen-Jones SM, Palczewski K. Retinal-chitosan conjugates effectively deliver active chromophores to retinal photoreceptor cells in blind mice and dogs. Molecular Pharmacology. PMID 29453250 DOI: 10.1124/Mol.117.111294  0.489
2018 Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR. New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701250R. PMID 29401616 DOI: 10.1096/Fj.201701250R  0.416
2018 Owen TS, Salom D, Sun W, Palczewski K. Increasing the Stability of Recombinant Human Green Cone Pigment. Biochemistry. PMID 29320632 DOI: 10.1021/Acs.Biochem.7B01118  0.438
2017 Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. A therapeutic combination of GPCR modulators that protects photoreceptors from degeneration. The Journal of Pharmacology and Experimental Therapeutics. PMID 29162627 DOI: 10.1124/Jpet.117.245167  0.81
2017 Penberthy KK, Rival C, Shankman LS, Raymond MH, Zhang J, Perry JSA, Lee CS, Han CZ, Onengut-Gumuscu S, Palczewski K, Lysiak JJ, Ravichandran KS. Context-dependent compensation among phosphatidylserine-recognition receptors. Scientific Reports. 7: 14623. PMID 29116131 DOI: 10.1038/S41598-017-15191-1  0.398
2017 Kolesnikov AV, Orban T, Jin H, Brooks C, Hofmann L, Dong Z, Sokolov M, Palczewski K, Kefalov VJ. Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078372 DOI: 10.1073/Pnas.1712405114  0.445
2017 Chiang CK, Tworak A, Kevany BM, Xu B, Mayne J, Ning Z, Figeys D, Palczewski K. Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium. The Journal of Biological Chemistry. PMID 28978645 DOI: 10.1074/Jbc.M117.812677  0.435
2017 Sears AE, Bernstein PS, Cideciyan AV, Hoyng C, Issa PC, Palczewski K, Rosenfeld PJ, Sadda S, Schraermeyer U, Sparrow JR, Washington I, Scholl HPN. Towards Treatment of Stargardt Disease: Workshop Organized and Sponsored by the Foundation Fighting Blindness. Translational Vision Science & Technology. 6: 6. PMID 28920007 DOI: 10.1167/Tvst.6.5.6  0.382
2017 Tonade D, Liu H, Palczewski K, Kern TS. Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes. Diabetologia. PMID 28755268 DOI: 10.1007/S00125-017-4381-5  0.359
2017 Sun D, Sahu B, Gao S, Schur RM, Vaidya AM, Maeda A, Palczewski K, Lu ZR. Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis. Molecular Therapy. Nucleic Acids. 7: 42-52. PMID 28624218 DOI: 10.1016/J.Omtn.2017.02.005  0.336
2017 Xue Y, Sato S, Razafsky D, Sahu B, Shen SQ, Potter C, Sandell LL, Corbo JC, Palczewski K, Maeda A, Hodzic D, Kefalov VJ. The role of retinol dehydrogenase 10 in the cone visual cycle. Scientific Reports. 7: 2390. PMID 28539612 DOI: 10.1038/S41598-017-02549-8  0.486
2017 Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop G, Palczewski K, Hendrich MP, Kiser PD. Structure and spectroscopy of alkene-cleaving dioxygenases containing an atypically coordinated non-heme iron center. Biochemistry. PMID 28493664 DOI: 10.1021/Acs.Biochem.7B00251  0.742
2017 Alexander NS, Katayama K, Sun W, Salom D, Gulati S, Zhang J, Mogi M, Palczewski K, Jastrzebska B. Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue. The Journal of Biological Chemistry. PMID 28487362 DOI: 10.1074/Jbc.M117.780478  0.488
2017 Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K. Rational tuning of visual cycle modulator pharmacodynamics. The Journal of Pharmacology and Experimental Therapeutics. PMID 28476927 DOI: 10.1124/Jpet.117.240721  0.808
2017 Hofmann L, Alexander NS, Sun W, Zhang J, Orban T, Palczewski K. Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors. Biochemistry. PMID 28402104 DOI: 10.1021/Acs.Biochem.7B00165  0.416
2017 Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K. Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proceedings of the National Academy of Sciences of the United States of America. PMID 28289214 DOI: 10.1073/Pnas.1617446114  0.81
2017 Sharma R, Schwarz C, Hunter JJ, Palczewska G, Palczewski K, Williams DR. Formation and Clearance of All-Trans-Retinol in Rods Investigated in the Living Primate Eye With Two-Photon Ophthalmoscopy. Investigative Ophthalmology & Visual Science. 58: 604-613. PMID 28129424 DOI: 10.1167/Iovs.16-20061  0.349
2017 Sundermeier TR, Sakami S, Sahu B, Howell SJ, Gao S, Dong Z, Golczak M, Maeda A, Palczewski K. microRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice. The Journal of Biological Chemistry. PMID 28104803 DOI: 10.1074/Jbc.M116.770024  0.34
2017 Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, ... Palczewski K, et al. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Human Molecular Genetics. PMID 28065882 DOI: 10.1093/Hmg/Ddw387  0.356
2016 Mustafi D, Kevany BM, Bai X, Golczak M, Adams MD, Wynshaw-Boris A, Palczewski K. Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas. Human Molecular Genetics. 25: 4376-4388. PMID 28172828 DOI: 10.1093/Hmg/Ddw268  0.411
2016 Jastrzebska B, Comar WD, Kaliszewski MJ, Skinner KC, Torcasio MH, Esway AS, Jin H, Palczewski K, Smith AW. A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins. Biochemistry. 61-72. PMID 28045251 DOI: 10.1021/Acs.Biochem.6B00877  0.389
2016 Schwarz C, Sharma R, Fischer WS, Chung M, Palczewska G, Palczewski K, Williams DR, Hunter JJ. Safety assessment in macaques of light exposures for functional two-photon ophthalmoscopy in humans. Biomedical Optics Express. 7: 5148-5169. PMID 28018732 DOI: 10.1364/Boe.7.005148  0.34
2016 Kiser PD, Palczewski K. Retinoids and Retinal Diseases. Annual Review of Vision Science. 2: 197-234. PMID 27917399 DOI: 10.1146/annurev-vision-111815-114407  0.789
2016 Palczewska G, Maeda A, Golczak M, Arai E, Dong Z, Perusek L, Kevany B, Palczewski K. Receptor tyrosine kinase MERTK is not required for transfer of bis-retinoids to the retinal pigmented epithelium. The Journal of Biological Chemistry. PMID 27875314 DOI: 10.1074/Jbc.M116.764563  0.429
2016 Chen Y, Brooks MJ, Gieser L, Swaroop A, Palczewski K. Transcriptome Profiling of NIH3T3 Cell Lines Expressing Opsin and the P23H Opsin Mutant Identifies Candidate Drugs for the Treatment of Retinitis Pigmentosa. Pharmacological Research. PMID 27838510 DOI: 10.1016/J.Phrs.2016.10.031  0.543
2016 Hofmann L, Tsybovsky Y, Alexander NS, Babino D, Leung NY, Montell C, Banerjee S, von Lintig J, Palczewski K. Structural insights into the Drosophila melanogaster retinol dehydrogenase, a member of the short-chain dehydrogenase/reductase family. Biochemistry. PMID 27809489 DOI: 10.1021/Acs.Biochem.6B00907  0.446
2016 Chen Y, Kern TS, Kiser PD, Palczewski K. Eyes on systems pharmacology. Pharmacological Research. PMID 27720767 DOI: 10.1016/J.Phrs.2016.09.026  0.743
2016 Rajavel M, Orban T, Xu M, Hernandez-Sanchez W, de la Fuente M, Palczewski K, Taylor DJ. Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance. Nucleic Acids Research. PMID 27655633 DOI: 10.1093/Nar/Gkw846  0.303
2016 Liu H, Tang J, Du Y, Saadane A, Tonade D, Samuels I, Veenstra A, Palczewski K, Kern TS. Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes. Investigative Ophthalmology & Visual Science. 57: 4272-4281. PMID 27548901 DOI: 10.1167/Iovs.16-19415  0.41
2016 Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Science Signaling. 9: ra74. PMID 27460988 DOI: 10.1126/Scisignal.Aag0245  0.803
2016 Yuan S, Chan HC, Vogel H, Filipek S, Stevens RC, Palczewski K. The Molecular Mechanism of P2Y1 Receptor Activation. Angewandte Chemie (International Ed. in English). PMID 27460867 DOI: 10.1002/Anie.201605147  0.305
2016 Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD. Key residues for catalytic function and metal coordination in a carotenoid cleavage dioxygenase. The Journal of Biological Chemistry. PMID 27453555 DOI: 10.1074/Jbc.M116.744912  0.772
2016 Sears AE, Palczewski K. Lecithin:retinol acyltransferase (LRAT): a key enzyme involved in the retinoid (visual) cycle. Biochemistry. PMID 27183166 DOI: 10.1021/Acs.Biochem.6B00319  0.469
2016 Han X, Tang J, Wang J, Ren F, Zheng J, Gragg M, Kiser P, Park PS, Palczewski K, Yao X, Zhang Y. Conformational change of human checkpoint kinase 1 (Chk1) induced by DNA damage. The Journal of Biological Chemistry. PMID 27129240 DOI: 10.1074/Jbc.M115.713248  0.754
2016 Alagramam KN, Gopal SR, Geng R, Chen DH, Nemet I, Lee R, Tian G, Miyagi M, Malagu KF, Lock CJ, Esmieu WR, Owens AP, Lindsay NA, Ouwehand K, Albertus F, ... ... Palczewski K, et al. A small molecule mitigates hearing loss in a mouse model of Usher syndrome III. Nature Chemical Biology. PMID 27110679 DOI: 10.1038/Nchembio.2069  0.654
2016 Sharma R, Schwarz C, Williams DR, Palczewska G, Palczewski K, Hunter JJ. In Vivo Two-Photon Fluorescence Kinetics of Primate Rods and Cones. Investigative Ophthalmology & Visual Science. 57: 647-57. PMID 26903225 DOI: 10.1167/Iovs.15-17946  0.358
2016 Sharma R, Williams DR, Palczewska G, Palczewski K, Hunter JJ. Two-Photon Autofluorescence Imaging Reveals Cellular Structures Throughout the Retina of the Living Primate Eye. Investigative Ophthalmology & Visual Science. 57: 632-46. PMID 26903224 DOI: 10.1167/Iovs.15-17961  0.382
2016 Babino D, Golczak M, Kiser PD, Wyss A, Palczewski K, von Lintig J. The biochemical basis of vitamin A3 production in arthropod vision. Acs Chemical Biology. PMID 26811964 DOI: 10.1021/Acschembio.5B00967  0.786
2016 Kaliszewski MJ, Comar WD, Skinner KC, Jastrzebska B, Palczewski K, Smith AW. Probing the Dimerization Affinity of Visual Opsins Biophysical Journal. 110: 592a-593a. DOI: 10.1016/J.Bpj.2015.11.3162  0.464
2015 Sui X, Golczak M, Zhang J, Kleinberg KA, von Lintig J, Palczewski K, Kiser PD. Utilization of Dioxygen by Carotenoid Cleavage Oxygenases. The Journal of Biological Chemistry. PMID 26499794 DOI: 10.1074/Jbc.M115.696799  0.756
2015 Perusek L, Sahu B, Parmar T, Maeno H, Arai E, Le YZ, Subauste CS, Chen Y, Palczewski K, Maeda A. A2E Accumulation and the Maintenance of the Visual Cycle are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. The Journal of Biological Chemistry. PMID 26468292 DOI: 10.1074/Jbc.M115.682310  0.393
2015 Sahu B, Sun W, Perusek L, Parmar V, Le YZ, Griswold MD, Palczewski K, Maeda A. Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. The Journal of Biological Chemistry. PMID 26391396 DOI: 10.1074/Jbc.M115.682096  0.467
2015 Kolesnikov AV, Maeda A, Tang PH, Imanishi Y, Palczewski K, Kefalov VJ. Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina. The Journal of Physiology. PMID 26350353 DOI: 10.1113/Jp271285  0.719
2015 Jastrzebska B, Chen Y, Orban T, Jin H, Hofmann L, Palczewski K. Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface. The Journal of Biological Chemistry. 290: 25728-44. PMID 26330551 DOI: 10.1074/Jbc.M115.662684  0.471
2015 Jacobson SG, Cideciyan AV, Aguirre GD, Roman AJ, Sumaroka A, Hauswirth WW, Palczewski K. Improvement in vision: a new goal for treatment of hereditary retinal degenerations. Expert Opinion On Orphan Drugs. 3: 563-575. PMID 26246977 DOI: 10.1517/21678707.2015.1030393  0.406
2015 Schur RM, Sheng L, Sahu B, Yu G, Gao S, Yu X, Maeda A, Palczewski K, Lu ZR. Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments. Investigative Ophthalmology & Visual Science. 56: 4936-42. PMID 26225634 DOI: 10.1167/Iovs.15-16522  0.386
2015 Orban T, Johnson WM, Dong Z, Maeda T, Maeda A, Sakai T, Tsuneoka H, Mieyal JJ, Palczewski K. Serum levels of lipid metabolites in age-related macular degeneration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26187344 DOI: 10.1096/Fj.15-275289  0.392
2015 Liu H, Tang J, Du Y, Lee CA, Golczak M, Muthusamy A, Antonetti DA, Veenstra AA, Amengual J, Von Lintig J, Palczewski K, Kern TS. Retinylamine Benefits Early Diabetic Retinopathy in Mice. The Journal of Biological Chemistry. PMID 26139608 DOI: 10.1074/Jbc.M115.655555  0.356
2015 Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K. Molecular pharmacodynamics of emixustat in protection against retinal degeneration. The Journal of Clinical Investigation. 125: 2781-94. PMID 26075817 DOI: 10.1172/Jci80950  0.819
2015 Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nature Chemical Biology. 11: 409-15. PMID 25894083 DOI: 10.1038/Nchembio.1799  0.809
2015 Chen Y, Palczewski K. Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders. Annual Review of Pharmacology and Toxicology. PMID 25839098 DOI: 10.1146/Annurev-Pharmtox-010715-103033  0.321
2015 Chen Y, Tang H, Seibel W, Papoian R, Li X, Lambert NA, Palczewski K. A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation. Investigative Ophthalmology & Visual Science. 56: 2553-67. PMID 25783607 DOI: 10.1167/Iovs.14-16298  0.496
2015 Zhang N, Tsybovsky Y, Kolesnikov AV, Rozanowska M, Swider M, Schwartz SB, Stone EM, Palczewska G, Maeda A, Kefalov VJ, Jacobson SG, Cideciyan AV, Palczewski K. Protein misfolding and the pathogenesis of ABCA4-associated retinal degenerations. Human Molecular Genetics. 24: 3220-37. PMID 25712131 DOI: 10.1093/Hmg/Ddv073  0.421
2015 Hofmann L, Palczewski K. The G protein-coupled receptor rhodopsin: a historical perspective. Methods in Molecular Biology (Clifton, N.J.). 1271: 3-18. PMID 25697513 DOI: 10.1007/978-1-4939-2330-4_1  0.434
2015 Du Y, Cramer M, Lee CA, Tang J, Muthusamy A, Antonetti DA, Jin H, Palczewski K, Kern TS. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 2194-204. PMID 25667222 DOI: 10.1096/Fj.14-269431  0.35
2015 Puntel A, Maeda A, Golczak M, Gao SQ, Yu G, Palczewski K, Lu ZR. Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles. Biomaterials. 44: 103-10. PMID 25617130 DOI: 10.1016/J.Biomaterials.2014.12.019  0.457
2015 Kevany BM, Zhang N, Jastrzebska B, Palczewski K. Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degeneration. Human Molecular Genetics. 24: 2627-40. PMID 25616964 DOI: 10.1093/Hmg/Ddv025  0.455
2015 Zhang J, Dong Z, Mundla SR, Hu XE, Seibel W, Papoian R, Palczewski K, Golczak M. Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration. Molecular Pharmacology. 87: 477-91. PMID 25538117 DOI: 10.1124/Mol.114.096560  0.489
2015 Salom D, Cao P, Yuan Y, Miyagi M, Feng Z, Palczewski K. Isotopic labeling of mammalian G protein-coupled receptors heterologously expressed in Caenorhabditis elegans. Analytical Biochemistry. 472: 30-6. PMID 25461480 DOI: 10.1016/J.Ab.2014.11.008  0.306
2015 Golczak M, Sears AE, Kiser PD, Palczewski K. LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3. Nature Chemical Biology. 11: 26-32. PMID 25383759 DOI: 10.1038/Nchembio.1687  0.778
2015 Chiang WC, Kroeger H, Sakami S, Messah C, Yasumura D, Matthes MT, Coppinger JA, Palczewski K, LaVail MM, Lin JH. Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration. Molecular Neurobiology. 52: 679-95. PMID 25270370 DOI: 10.1007/S12035-014-8881-8  0.404
2015 Sharma R, Schwarz C, Williams DR, Palczewska G, Palczewski K, Hunter JJ. Two-photon autofluorescence imaging of retinal structure and function in the living primate eye Proceedings of Frontiers in Optics 2015, Fio 2015. DOI: 10.1364/Fio.2015.Ftu5B.3  0.364
2014 Palczewska G, Vinberg F, Stremplewski P, Bircher MP, Salom D, Komar K, Zhang J, Cascella M, Wojtkowski M, Kefalov VJ, Palczewski K. Human infrared vision is triggered by two-photon chromophore isomerization. Proceedings of the National Academy of Sciences of the United States of America. 111: E5445-54. PMID 25453064 DOI: 10.1073/Pnas.1410162111  0.397
2014 Palczewski K. Chemistry and biology of the initial steps in vision: the Friedenwald lecture. Investigative Ophthalmology & Visual Science. 55: 6651-72. PMID 25338686 DOI: 10.1167/Iovs.14-15502  0.481
2014 Palczewska G, Golczak M, Williams DR, Hunter JJ, Palczewski K. Endogenous fluorophores enable two-photon imaging of the primate eye. Investigative Ophthalmology & Visual Science. 55: 4438-47. PMID 24970255 DOI: 10.1167/Iovs.14-14395  0.328
2014 Palczewska G, Dong Z, Golczak M, Hunter JJ, Williams DR, Alexander NS, Palczewski K. Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye. Nature Medicine. 20: 785-9. PMID 24952647 DOI: 10.1038/Nm.3590  0.432
2014 Chen Y, Tang H, Seibel W, Papoian R, Oh K, Li X, Zhang J, Golczak M, Palczewski K, Kiser PD. Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase. Molecular Pharmacology. 86: 231-42. PMID 24913940 DOI: 10.1124/Mol.114.093070  0.778
2014 Amengual J, Zhang N, Kemerer M, Maeda T, Palczewski K, Von Lintig J. STRA6 is critical for cellular vitamin A uptake and homeostasis. Human Molecular Genetics. 23: 5402-17. PMID 24852372 DOI: 10.1093/Hmg/Ddu258  0.307
2014 Sundermeier TR, Zhang N, Vinberg F, Mustafi D, Kohno H, Golczak M, Bai X, Maeda A, Kefalov VJ, Palczewski K. DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 3780-91. PMID 24812086 DOI: 10.1096/Fj.14-254292  0.375
2014 Maeda A, Palczewska G, Golczak M, Kohno H, Dong Z, Maeda T, Palczewski K. Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 111: E1428-37. PMID 24706832 DOI: 10.1073/Pnas.1317986111  0.442
2014 Orban T, Jastrzebska B, Palczewski K. Structural approaches to understanding retinal proteins needed for vision. Current Opinion in Cell Biology. 27: 32-43. PMID 24680428 DOI: 10.1016/J.Ceb.2013.11.001  0.453
2014 Sui X, Kiser PD, Che T, Carey PR, Golczak M, Shi W, von Lintig J, Palczewski K. Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO). The Journal of Biological Chemistry. 289: 12286-99. PMID 24648526 DOI: 10.1074/Jbc.M114.552836  0.792
2014 Tu X, Palczewski K. The macular degeneration-linked C1QTNF5 (S163) mutation causes higher-order structural rearrangements. Journal of Structural Biology. 186: 86-94. PMID 24531000 DOI: 10.1016/J.Jsb.2014.02.001  0.396
2014 Sundermeier TR, Vinberg F, Mustafi D, Bai X, Kefalov VJ, Palczewski K. R9AP overexpression alters phototransduction kinetics in iCre75 mice. Investigative Ophthalmology & Visual Science. 55: 1339-47. PMID 24526444 DOI: 10.1167/Iovs.13-13564  0.338
2014 Chen Y, Jastrzebska B, Cao P, Zhang J, Wang B, Sun W, Yuan Y, Feng Z, Palczewski K. Inherent instability of the retinitis pigmentosa P23H mutant opsin. The Journal of Biological Chemistry. 289: 9288-303. PMID 24515108 DOI: 10.1074/Jbc.M114.551713  0.527
2014 Wu X, Yu G, Luo C, Maeda A, Zhang N, Sun D, Zhou Z, Puntel A, Palczewski K, Lu ZR. Synthesis and evaluation of a nanoglobular dendrimer 5-aminosalicylic Acid conjugate with a hydrolyzable schiff base spacer for treating retinal degeneration. Acs Nano. 8: 153-61. PMID 24350906 DOI: 10.1021/Nn4054107  0.391
2014 Bolze CS, Helbling RE, Owen RL, Pearson AR, Pompidor G, Dworkowski F, Fuchs MR, Furrer J, Golczak M, Palczewski K, Cascella M, Stocker A. Human cellular retinaldehyde-binding protein has secondary thermal 9-cis-retinal isomerase activity Journal of the American Chemical Society. 136: 137-146. PMID 24328211 DOI: 10.1021/Ja411366W  0.468
2014 Sakami S, Kolesnikov AV, Kefalov VJ, Palczewski K. P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Human Molecular Genetics. 23: 1723-41. PMID 24214395 DOI: 10.1093/Hmg/Ddt561  0.391
2014 Kiser PD, Golczak M, Palczewski K. Chemistry of the retinoid (visual) cycle. Chemical Reviews. 114: 194-232. PMID 23905688 DOI: 10.1021/Cr400107Q  0.808
2013 Chen Y, Palczewska G, Mustafi D, Golczak M, Dong Z, Sawada O, Maeda T, Maeda A, Palczewski K. Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration. The Journal of Clinical Investigation. 123: 5119-34. PMID 24231350 DOI: 10.1172/Jci69076  0.352
2013 Kevany BM, Tsybovsky Y, Campuzano ID, Schnier PD, Engel A, Palczewski K. Structural and functional analysis of the native peripherin-ROM1 complex isolated from photoreceptor cells. The Journal of Biological Chemistry. 288: 36272-84. PMID 24196967 DOI: 10.1074/Jbc.M113.520700  0.416
2013 Maeda T, Lee MJ, Palczewska G, Marsili S, Tesar PJ, Palczewski K, Takahashi M, Maeda A. Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo. The Journal of Biological Chemistry. 288: 34484-93. PMID 24129572 DOI: 10.1074/Jbc.M113.518571  0.423
2013 Sharma R, Yin L, Geng Y, Merigan WH, Palczewska G, Palczewski K, Williams DR, Hunter JJ. In vivo two-photon imaging of the mouse retina. Biomedical Optics Express. 4: 1285-93. PMID 24009992 DOI: 10.1364/Boe.4.001285  0.358
2013 Helbling RE, Bolze CS, Golczak M, Palczewski K, Stocker A, Cascella M. Cellular retinaldehyde binding protein - Different binding modes and micro-solvation patterns for high-affinity 9-cis- and 11-cis-retinal substrates Journal of Physical Chemistry B. 117: 10719-10729. PMID 23964907 DOI: 10.1021/Jp405410T  0.414
2013 Mustafi D, Kevany BM, Genoud C, Bai X, Palczewski K. Photoreceptor phagocytosis is mediated by phosphoinositide signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 4585-95. PMID 23913857 DOI: 10.1096/Fj.13-237537  0.408
2013 Sui X, Kiser PD, Lintig Jv, Palczewski K. Structural basis of carotenoid cleavage: from bacteria to mammals. Archives of Biochemistry and Biophysics. 539: 203-13. PMID 23827316 DOI: 10.1016/J.Abb.2013.06.012  0.776
2013 Kowatz T, Babino D, Kiser P, Palczewski K, von Lintig J. Characterization of human β,β-carotene-15,15'-monooxygenase (BCMO1) as a soluble monomeric enzyme. Archives of Biochemistry and Biophysics. 539: 214-22. PMID 23727499 DOI: 10.1016/J.Abb.2013.05.007  0.756
2013 Palczewski K, Orban T. From atomic structures to neuronal functions of g protein-coupled receptors. Annual Review of Neuroscience. 36: 139-64. PMID 23682660 DOI: 10.1146/Annurev-Neuro-062012-170313  0.36
2013 Palczewski K, Kiser PD. Biochemistry. As good as chocolate. Science (New York, N.Y.). 340: 562-3. PMID 23641106 DOI: 10.1126/Science.1238521  0.744
2013 Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A. Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. The Journal of Biological Chemistry. 288: 15326-41. PMID 23572532 DOI: 10.1074/Jbc.M112.448712  0.45
2013 Mustafi D, Kevany BM, Bai X, Maeda T, Sears JE, Khalil AM, Palczewski K. Evolutionarily conserved long intergenic non-coding RNAs in the eye. Human Molecular Genetics. 22: 2992-3002. PMID 23562822 DOI: 10.1093/Hmg/Ddt156  0.41
2013 Tsybovsky Y, Orban T, Molday RS, Taylor D, Palczewski K. Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter. Structure (London, England : 1993). 21: 854-60. PMID 23562398 DOI: 10.1016/J.Str.2013.03.001  0.323
2013 Tian M, Zallocchi M, Wang W, Chen CK, Palczewski K, Delimont D, Cosgrove D, Peng YW. Light-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptors. Plos One. 8: e58832. PMID 23555598 DOI: 10.1371/Journal.Pone.0058832  0.359
2013 Jastrzebska B, Ringler P, Palczewski K, Engel A. The rhodopsin-transducin complex houses two distinct rhodopsin molecules. Journal of Structural Biology. 182: 164-72. PMID 23458690 DOI: 10.1016/J.Jsb.2013.02.014  0.382
2013 Padayatti PS, Wang L, Gupta S, Orban T, Sun W, Salom D, Jordan SR, Palczewski K, Chance MR. A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4). Molecular & Cellular Proteomics : McP. 12: 1259-71. PMID 23378516 DOI: 10.1074/Mcp.M112.025536  0.32
2013 Jastrzebska B, Salom D, Jin H, Cao P, Sun W, Palczewski K, Feng Z. Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans. Methods in Enzymology. 520: 239-56. PMID 23332703 DOI: 10.1016/B978-0-12-391861-1.00011-3  0.382
2013 Jastrzebska B, Orban T, Golczak M, Engel A, Palczewski K. Asymmetry of the rhodopsin dimer in complex with transducin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1572-84. PMID 23303210 DOI: 10.1096/Fj.12-225383  0.424
2013 Maeda T, Dong Z, Jin H, Sawada O, Gao S, Utkhede D, Monk W, Palczewska G, Palczewski K. QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles. Investigative Ophthalmology & Visual Science. 54: 455-66. PMID 23249702 DOI: 10.1167/Iovs.12-11152  0.463
2013 Zhang N, Kolesnikov AV, Jastrzebska B, Mustafi D, Sawada O, Maeda T, Genoud C, Engel A, Kefalov VJ, Palczewski K. Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. The Journal of Clinical Investigation. 123: 121-37. PMID 23221340 DOI: 10.1172/Jci66176  0.453
2013 Palczewska G, Palczewski K. Molecular imaging of the visual cycle Optics Infobase Conference Papers. DOI: 10.1364/Fio.2013.Ftu4I.1  0.468
2012 Kiser PD, Farquhar ER, Shi W, Sui X, Chance MR, Palczewski K. Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proceedings of the National Academy of Sciences of the United States of America. 109: E2747-56. PMID 23012475 DOI: 10.1073/Pnas.1212025109  0.771
2012 Tu X, Palczewski K. Crystal structure of the globular domain of C1QTNF5: Implications for late-onset retinal macular degeneration. Journal of Structural Biology. 180: 439-46. PMID 22892318 DOI: 10.1016/J.Jsb.2012.07.011  0.409
2012 Mustafi D, Maeda T, Kohno H, Nadeau JH, Palczewski K. Inflammatory priming predisposes mice to age-related retinal degeneration. The Journal of Clinical Investigation. 122: 2989-3001. PMID 22797304 DOI: 10.1172/Jci64427  0.402
2012 Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. The Journal of Biological Chemistry. 287: 23790-807. PMID 22605381 DOI: 10.1074/Jbc.M112.361550  0.773
2012 Sexton TJ, Golczak M, Palczewski K, Van Gelder RN. Melanopsin is highly resistant to light and chemical bleaching in vivo. The Journal of Biological Chemistry. 287: 20888-97. PMID 22547062 DOI: 10.1074/Jbc.M111.325969  0.457
2012 Chen Y, Farquhar ER, Chance MR, Palczewski K, Kiser PD. Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. The Journal of Biological Chemistry. 287: 13356-70. PMID 22356908 DOI: 10.1074/Jbc.M112.347518  0.784
2012 Okano K, Maeda A, Chen Y, Chauhan V, Tang J, Palczewska G, Sakai T, Tsuneoka H, Palczewski K, Maeda T. Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light-induced damage. Journal of Neurochemistry. 121: 146-56. PMID 22220722 DOI: 10.1111/J.1471-4159.2012.07647.X  0.457
2012 Maeda A, Golczak M, Chen Y, Okano K, Kohno H, Shiose S, Ishikawa K, Harte W, Palczewska G, Maeda T, Palczewski K. Primary amines protect against retinal degeneration in mouse models of retinopathies. Nature Chemical Biology. 8: 170-8. PMID 22198730 DOI: 10.1038/Nchembio.759  0.466
2012 Chen Y, Okano K, Maeda T, Chauhan V, Golczak M, Maeda A, Palczewski K. Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration. The Journal of Biological Chemistry. 287: 5059-69. PMID 22184108 DOI: 10.1074/Jbc.M111.315432  0.422
2012 Salom D, Wang B, Dong Z, Sun W, Padayatti P, Jordan S, Salon JA, Palczewski K. Post-translational modifications of the serotonin type 4 receptor heterologously expressed in mouse rod cells. Biochemistry. 51: 214-24. PMID 22145929 DOI: 10.1021/Bi201707V  0.346
2012 Salom D, Cao P, Sun W, Kramp K, Jastrzebska B, Jin H, Feng Z, Palczewski K. Heterologous expression of functional G-protein-coupled receptors in Caenorhabditis elegans. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 492-502. PMID 22090314 DOI: 10.1096/Fj.11-197780  0.365
2012 Cao P, Sun W, Kramp K, Zheng M, Salom D, Jastrzebska B, Jin H, Palczewski K, Feng Z. Light-sensitive coupling of rhodopsin and melanopsin to G(i/o) and G(q) signal transduction in Caenorhabditis elegans. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 480-91. PMID 22090313 DOI: 10.1096/Fj.11-197798  0.329
2012 Kiser PD, Golczak M, Maeda A, Palczewski K. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochimica Et Biophysica Acta. 1821: 137-51. PMID 21447403 DOI: 10.1016/J.Bbalip.2011.03.005  0.824
2011 Palczewski K. Thematic minireview series on focus on vision. The Journal of Biological Chemistry. 287: 1610-1. PMID 22074916 DOI: 10.1074/Jbc.R111.322347  0.51
2011 Salon JA, Lodowski DT, Palczewski K. The significance of G protein-coupled receptor crystallography for drug discovery. Pharmacological Reviews. 63: 901-37. PMID 21969326 DOI: 10.1124/Pr.110.003350  0.313
2011 Zhu Q, Sun W, Okano K, Chen Y, Zhang N, Maeda T, Palczewski K. Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina. The Journal of Biological Chemistry. 286: 31749-60. PMID 21768104 DOI: 10.1074/Jbc.M111.259028  0.324
2011 Tsybovsky Y, Wang B, Quazi F, Molday RS, Palczewski K. Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4. Biochemistry. 50: 6855-66. PMID 21721517 DOI: 10.1021/Bi200774W  0.416
2011 Mustafi D, Kevany BM, Genoud C, Okano K, Cideciyan AV, Sumaroka A, Roman AJ, Jacobson SG, Engel A, Adams MD, Palczewski K. Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3157-76. PMID 21659555 DOI: 10.1096/Fj.11-186767  0.453
2011 Peshenko IV, Olshevskaya EV, Savchenko AB, Karan S, Palczewski K, Baehr W, Dizhoor AM. Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors. Biochemistry. 50: 5590-600. PMID 21598940 DOI: 10.1021/Bi200491B  0.384
2011 Orban T, Palczewska G, Palczewski K. Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissues. The Journal of Biological Chemistry. 286: 17248-58. PMID 21454509 DOI: 10.1074/Jbc.M110.195198  0.422
2011 Mustafi D, Avishai A, Avishai N, Engel A, Heuer A, Palczewski K. Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology. Journal of Neuroscience Methods. 198: 70-6. PMID 21439323 DOI: 10.1016/J.Jneumeth.2011.03.013  0.382
2011 Shiose S, Chen Y, Okano K, Roy S, Kohno H, Tang J, Pearlman E, Maeda T, Palczewski K, Maeda A. Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. The Journal of Biological Chemistry. 286: 15543-55. PMID 21383019 DOI: 10.1074/Jbc.M111.228551  0.401
2011 Huang CC, Orban T, Jastrzebska B, Palczewski K, Tesmer JJ. Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain. Biochemistry. 50: 1940-9. PMID 21265573 DOI: 10.1021/Bi101606E  0.311
2011 Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA. Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. The Journal of Biological Chemistry. 286: 5607-13. PMID 21159775 DOI: 10.1074/Jbc.M110.188433  0.301
2010 Hunter JJ, Masella B, Dubra A, Sharma R, Yin L, Merigan WH, Palczewska G, Palczewski K, Williams DR. Images of photoreceptors in living primate eyes using adaptive optics two-photon ophthalmoscopy. Biomedical Optics Express. 2: 139-48. PMID 21326644 DOI: 10.1364/Boe.2.000139  0.315
2010 Palczewska G, Maeda T, Imanishi Y, Sun W, Chen Y, Williams DR, Piston DW, Maeda A, Palczewski K. Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes. Nature Medicine. 16: 1444-9. PMID 21076393 DOI: 10.1038/Nm.2260  0.714
2010 Palczewski K. Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle. Archives of Ophthalmology (Chicago, Ill. : 1960). 128: 1483-5. PMID 21060052 DOI: 10.1001/Archophthalmol.2010.245  0.445
2010 Lodowski DT, Palczewski K, Miyagi M. Conformational changes in the g protein-coupled receptor rhodopsin revealed by histidine hydrogen-deuterium exchange. Biochemistry. 49: 9425-7. PMID 20939497 DOI: 10.1021/Bi101502V  0.334
2010 Tsybovsky Y, Molday RS, Palczewski K. The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease. Advances in Experimental Medicine and Biology. 703: 105-25. PMID 20711710 DOI: 10.1007/978-1-4419-5635-4_8  0.38
2010 Goc A, Chami M, Lodowski DT, Bosshart P, Moiseenkova-Bell V, Baehr W, Engel A, Palczewski K. Structural characterization of the rod cGMP phosphodiesterase 6. Journal of Molecular Biology. 401: 363-73. PMID 20600113 DOI: 10.1016/J.Jmb.2010.06.044  0.348
2010 Imanishi Y, Palczewski K. Visualization of retinoid storage and trafficking by two-photon microscopy. Methods in Molecular Biology (Clifton, N.J.). 652: 247-61. PMID 20552433 DOI: 10.1007/978-1-60327-325-1_14  0.731
2010 Golczak M, Bereta G, Maeda A, Palczewski K. Molecular biology and analytical chemistry methods used to probe the retinoid cycle. Methods in Molecular Biology (Clifton, N.J.). 652: 229-45. PMID 20552432 DOI: 10.1007/978-1-60327-325-1_13  0.449
2010 Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K. Palmitoylation stabilizes unliganded rod opsin. Proceedings of the National Academy of Sciences of the United States of America. 107: 8428-33. PMID 20404157 DOI: 10.1073/Pnas.1000640107  0.449
2010 Kiser PD, Palczewski K. Membrane-binding and enzymatic properties of RPE65. Progress in Retinal and Eye Research. 29: 428-42. PMID 20304090 DOI: 10.1016/J.Preteyeres.2010.03.002  0.806
2010 von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends in Biochemical Sciences. 35: 400-10. PMID 20188572 DOI: 10.1016/J.Tibs.2010.01.005  0.78
2010 Orban T, Bereta G, Miyagi M, Wang B, Chance MR, Sousa MC, Palczewski K. Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation. Structure (London, England : 1993). 18: 116-26. PMID 20152158 DOI: 10.1016/J.Str.2009.11.008  0.317
2010 Kevany BM, Palczewski K. Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda, Md.). 25: 8-15. PMID 20134024 DOI: 10.1152/Physiol.00038.2009  0.391
2010 Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K. Importance of membrane structural integrity for RPE65 retinoid isomerization activity. The Journal of Biological Chemistry. 285: 9667-82. PMID 20100834 DOI: 10.1074/Jbc.M109.063941  0.806
2010 O'Byrne SM, Kako Y, Deckelbaum RJ, Hansen IH, Palczewski K, Goldberg IJ, Blaner WS. Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice. American Journal of Physiology. Endocrinology and Metabolism. 298: E862-70. PMID 20040693 DOI: 10.1152/Ajpendo.00491.2009  0.317
2010 Moise AR, Lobo GP, Erokwu B, Wilson DL, Peck D, Alvarez S, Domínguez M, Alvarez R, Flask CA, de Lera AR, von Lintig J, Palczewski K. Increased adiposity in the retinol saturase-knockout mouse. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 1261-70. PMID 19940255 DOI: 10.1096/Fj.09-147207  0.307
2010 Bereta G, Wang B, Kiser PD, Baehr W, Jang GF, Palczewski K. A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1. The Journal of Biological Chemistry. 285: 1899-908. PMID 19901021 DOI: 10.1074/Jbc.M109.061713  0.778
2009 Kiser PD, Lorimer GH, Palczewski K. Use of thallium to identify monovalent cation binding sites in GroEL. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 967-71. PMID 19851000 DOI: 10.1107/S1744309109032928  0.751
2009 Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K. Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proceedings of the National Academy of Sciences of the United States of America. 106: 17325-30. PMID 19805034 DOI: 10.1073/Pnas.0906600106  0.824
2009 Moise AR, Alvarez S, Domínguez M, Alvarez R, Golczak M, Lobo GP, von Lintig J, de Lera AR, Palczewski K. Activation of retinoic acid receptors by dihydroretinoids. Molecular Pharmacology. 76: 1228-37. PMID 19770350 DOI: 10.1124/Mol.109.060038  0.302
2009 Angel TE, Gupta S, Jastrzebska B, Palczewski K, Chance MR. Structural waters define a functional channel mediating activation of the GPCR, rhodopsin. Proceedings of the National Academy of Sciences of the United States of America. 106: 14367-72. PMID 19706523 DOI: 10.1073/Pnas.0901074106  0.312
2009 Maeda A, Golczak M, Maeda T, Palczewski K. Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. Investigative Ophthalmology & Visual Science. 50: 5435-43. PMID 19553623 DOI: 10.1167/Iovs.09-3944  0.465
2009 Angel TE, Chance MR, Palczewski K. Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors. Proceedings of the National Academy of Sciences of the United States of America. 106: 8555-60. PMID 19433801 DOI: 10.1073/Pnas.0903545106  0.33
2009 Tian G, Zhou Y, Hajkova D, Miyagi M, Dinculescu A, Hauswirth WW, Palczewski K, Geng R, Alagramam KN, Isosomppi J, Sankila EM, Flannery JG, Imanishi Y. Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton. The Journal of Biological Chemistry. 284: 18980-93. PMID 19423712 DOI: 10.1074/Jbc.M109.003160  0.665
2009 Geng R, Geller SF, Hayashi T, Ray CA, Reh TA, Bermingham-McDonogh O, Jones SM, Wright CG, Melki S, Imanishi Y, Palczewski K, Alagramam KN, Flannery JG. Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation. Human Molecular Genetics. 18: 2748-60. PMID 19414487 DOI: 10.1093/Hmg/Ddp210  0.659
2009 Maeda T, Maeda A, Casadesus G, Palczewski K, Margaron P. Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/- mice. Investigative Ophthalmology & Visual Science. 50: 4368-78. PMID 19407008 DOI: 10.1167/Iovs.09-3700  0.373
2009 Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K. Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry. 48: 4294-304. PMID 19348429 DOI: 10.1021/Bi900417B  0.406
2009 Maeda A, Maeda T, Golczak M, Chou S, Desai A, Hoppel CL, Matsuyama S, Palczewski K. Involvement of all-trans-retinal in acute light-induced retinopathy of mice. The Journal of Biological Chemistry. 284: 15173-83. PMID 19304658 DOI: 10.1074/Jbc.M900322200  0.477
2009 Lodowski DT, Angel TE, Palczewski K. Comparative analysis of GPCR crystal structures. Photochemistry and Photobiology. 85: 425-30. PMID 19192200 DOI: 10.1111/J.1751-1097.2008.00516.X  0.404
2009 Cideciyan AV, Swider M, Aleman TS, Tsybovsky Y, Schwartz SB, Windsor EA, Roman AJ, Sumaroka A, Steinberg JD, Jacobson SG, Stone EM, Palczewski K. ABCA4 disease progression and a proposed strategy for gene therapy. Human Molecular Genetics. 18: 931-41. PMID 19074458 DOI: 10.1093/Hmg/Ddn421  0.342
2009 Jastrzebska B, Golczak M, Fotiadis D, Engel A, Palczewski K. Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin Faseb Journal. 23: 371-381. PMID 18827025 DOI: 10.1096/Fj.07-114835  0.375
2009 Provasi D, Palczewski K, Filizola M. Exploring the Thermodynamics of Activation Pathways of Bovine Rhodopsin with Fast Molecular Dynamics Simulations Biophysical Journal. 96: 679a. DOI: 10.1016/J.Bpj.2008.12.3586  0.407
2009 Gupta S, Angel T, Jastrzebska B, Palczewski K, Chance MR. X-ray Footprinting Studies on Photoactivation of Bovine Rhodopsin Biophysical Journal. 96: 195a. DOI: 10.1016/J.Bpj.2008.12.1047  0.388
2008 Salom D, Wu N, Sun W, Dong Z, Palczewski K, Jordan S, Salon JA. Heterologous expression and purification of the serotonin type 4 receptor from transgenic mouse retina. Biochemistry. 47: 13296-307. PMID 19053287 DOI: 10.1021/Bi8018527  0.392
2008 Goc A, Angel TE, Jastrzebska B, Wang B, Wintrode PL, Palczewski K. Different properties of the native and reconstituted heterotrimeric G protein transducin. Biochemistry. 47: 12409-19. PMID 18975915 DOI: 10.1021/Bi8015444  0.348
2008 Bereta G, Kiser PD, Golczak M, Sun W, Heon E, Saperstein DA, Palczewski K. Impact of retinal disease-associated RPE65 mutations on retinoid isomerization. Biochemistry. 47: 9856-65. PMID 18722466 DOI: 10.1021/Bi800905V  0.791
2008 Jiang L, Wheaton D, Bereta G, Zhang K, Palczewski K, Birch DG, Baehr W. A novel GCAP1(N104K) mutation in EF-hand 3 (EF3) linked to autosomal dominant cone dystrophy. Vision Research. 48: 2425-32. PMID 18706439 DOI: 10.1016/J.Visres.2008.07.016  0.344
2008 Maeda A, Maeda T, Golczak M, Palczewski K. Retinopathy in mice induced by disrupted all-trans-retinal clearance. The Journal of Biological Chemistry. 283: 26684-93. PMID 18658157 DOI: 10.1074/Jbc.M804505200  0.498
2008 Imanishi Y, Sun W, Maeda T, Maeda A, Palczewski K. Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina. The Journal of Biological Chemistry. 283: 25091-102. PMID 18606814 DOI: 10.1074/Jbc.M802981200  0.735
2008 Zhang H, Fan J, Li S, Karan S, Rohrer B, Palczewski K, Frederick JM, Crouch RK, Baehr W. Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4008-14. PMID 18400900 DOI: 10.1523/Jneurosci.0317-08.2008  0.475
2008 Stephen R, Filipek S, Palczewski K, Sousa MC. Ca 2+-dependent Regulation of Phototransduction Photochemistry and Photobiology. 84: 903-910. PMID 18346093 DOI: 10.1111/J.1751-1097.2008.00323.X  0.352
2008 Singh P, Wang B, Maeda T, Palczewski K, Tesmer JJ. Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. The Journal of Biological Chemistry. 283: 14053-62. PMID 18339619 DOI: 10.1074/Jbc.M708974200  0.302
2008 Müller DJ, Wu N, Palczewski K. Vertebrate membrane proteins: structure, function, and insights from biophysical approaches. Pharmacological Reviews. 60: 43-78. PMID 18321962 DOI: 10.1124/Pr.107.07111  0.309
2008 Isken A, Golczak M, Oberhauser V, Hunzelmann S, Driever W, Imanishi Y, Palczewski K, von Lintig J. RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. Cell Metabolism. 7: 258-68. PMID 18316031 DOI: 10.1016/J.Cmet.2008.01.009  0.666
2008 Sapra KT, Park PS, Palczewski K, Muller DJ. Mechanical properties of bovine rhodopsin and bacteriorhodopsin: possible roles in folding and function. Langmuir : the Acs Journal of Surfaces and Colloids. 24: 1330-7. PMID 18266338 DOI: 10.1021/La702299Z  0.32
2008 Golczak M, Maeda A, Bereta G, Maeda T, Kiser PD, Hunzelmann S, von Lintig J, Blaner WS, Palczewski K. Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. The Journal of Biological Chemistry. 283: 9543-54. PMID 18195010 DOI: 10.1074/Jbc.M708982200  0.815
2008 Moise AR, Domínguez M, Alvarez S, Alvarez R, Schupp M, Cristancho AG, Kiser PD, de Lera AR, Lazar MA, Palczewski K. Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. Journal of the American Chemical Society. 130: 1154-5. PMID 18179220 DOI: 10.1021/Ja710487Q  0.755
2008 Whorton MR, Jastrzebska B, Park PS, Fotiadis D, Engel A, Palczewski K, Sunahara RK. Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. The Journal of Biological Chemistry. 283: 4387-94. PMID 18033822 DOI: 10.1074/Jbc.M703346200  0.352
2008 Park PS, Lodowski DT, Palczewski K. Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes. Annual Review of Pharmacology and Toxicology. 48: 107-41. PMID 17848137 DOI: 10.1146/Annurev.Pharmtox.48.113006.094630  0.328
2007 Baehr W, Palczewski K. Guanylate cyclase-activating proteins and retina disease Sub-Cellular Biochemistry. 45: 71-91. PMID 18193635 DOI: 10.1007/978-1-4020-6191-2_4  0.393
2007 Maeda A, Maeda T, Sun W, Zhang H, Baehr W, Palczewski K. Redundant and unique roles of retinol dehydrogenases in the mouse retina. Proceedings of the National Academy of Sciences of the United States of America. 104: 19565-70. PMID 18048336 DOI: 10.1073/Pnas.0707477104  0.479
2007 Schonthaler HB, Lampert JM, Isken A, Rinner O, Mader A, Gesemann M, Oberhauser V, Golczak M, Biehlmaier O, Palczewski K, Neuhauss SC, von Lintig J. Evidence for RPE65-independent vision in the cone-dominated zebrafish retina. The European Journal of Neuroscience. 26: 1940-9. PMID 17868371 DOI: 10.1111/J.1460-9568.2007.05801.X  0.489
2007 Jacobson SG, Aleman TS, Cideciyan AV, Heon E, Golczak M, Beltran WA, Sumaroka A, Schwartz SB, Roman AJ, Windsor EA, Wilson JM, Aguirre GD, Stone EM, Palczewski K. Human cone photoreceptor dependence on RPE65 isomerase. Proceedings of the National Academy of Sciences of the United States of America. 104: 15123-8. PMID 17848510 DOI: 10.1073/Pnas.0706367104  0.485
2007 Li N, Salom D, Zhang L, Harris T, Ballesteros JA, Golczak M, Jastrzebska B, Palczewski K, Kurahara C, Juan T, Jordan S, Salon JA. Heterologous expression of the adenosine A1 receptor in transgenic mouse retina. Biochemistry. 46: 8350-9. PMID 17580959 DOI: 10.1021/Bi700154H  0.378
2007 Kiser PD, Lodowski DT, Palczewski K. Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 63: 457-61. PMID 17554162 DOI: 10.1107/S1744309107020295  0.748
2007 Sun W, Gerth C, Maeda A, Lodowski DT, Van Der Kraak L, Saperstein DA, Héon E, Palczewski K. Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations. Vision Research. 47: 2055-66. PMID 17512964 DOI: 10.1016/J.Visres.2007.04.005  0.346
2007 Pin JP, Neubig R, Bouvier M, Devi L, Filizola M, Javitch JA, Lohse MJ, Milligan G, Palczewski K, Parmentier M, Spedding M. International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacological Reviews. 59: 5-13. PMID 17329545 DOI: 10.1124/Pr.59.1.5  0.305
2007 Ridge KD, Palczewski K. Visual rhodopsin sees the light: Structure and mechanism of G protein signaling Journal of Biological Chemistry. 282: 9297-9301. PMID 17289671 DOI: 10.1074/Jbc.R600032200  0.417
2007 Baehr W, Karan S, Maeda T, Luo DG, Li S, Bronson JD, Watt CB, Yau KW, Frederick JM, Palczewski K. The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. The Journal of Biological Chemistry. 282: 8837-47. PMID 17255100 DOI: 10.1074/Jbc.M610369200  0.409
2007 Moise AR, Golczak M, Imanishi Y, Palczewski K. Topology and membrane association of lecithin: retinol acyltransferase. The Journal of Biological Chemistry. 282: 2081-90. PMID 17114808 DOI: 10.1074/Jbc.M608315200  0.676
2007 Isken A, Holzschuh J, Lampert JM, Fischer L, Oberhauser V, Palczewski K, Von Lintig J. Sequestration of retinyl esters is essential for retinoid signaling in the zebrafish embryo Journal of Biological Chemistry. 282: 1144-1151. PMID 17098734 DOI: 10.1074/Jbc.M609109200  0.385
2006 Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proceedings of the National Academy of Sciences of the United States of America. 103: 16123-8. PMID 17060607 DOI: 10.1073/Pnas.0608022103  0.325
2006 Maeda A, Maeda T, Imanishi Y, Sun W, Jastrzebska B, Hatala DA, Winkens HJ, Hofmann KP, Janssen JJ, Baehr W, Driessen CA, Palczewski K. Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. The Journal of Biological Chemistry. 281: 37697-704. PMID 17032653 DOI: 10.1074/Jbc.M608375200  0.738
2006 Maeda A, Maeda T, Palczewski K. Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal. Investigative Ophthalmology & Visual Science. 47: 4540-6. PMID 17003450 DOI: 10.1167/Iovs.06-0215  0.454
2006 Haire SE, Pang J, Boye SL, Sokal I, Craft CM, Palczewski K, Hauswirth WW, Semple-Rowland SL. Light-driven cone arrestin translocation in cones of postnatal guanylate cyclase-1 knockout mouse retina treated with AAV-GC1. Investigative Ophthalmology & Visual Science. 47: 3745-53. PMID 16936082 DOI: 10.1167/Iovs.06-0086  0.411
2006 Maeda A, Maeda T, Golczak M, Imanishi Y, Leahy P, Kubota R, Palczewski K. Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice. Molecular Pharmacology. 70: 1220-9. PMID 16837623 DOI: 10.1124/Mol.106.026823  0.75
2006 Salom D, Le Trong I, Pohl E, Ballesteros JA, Stenkamp RE, Palczewski K, Lodowski DT. Improvements in G protein-coupled receptor purification yield light stable rhodopsin crystals. Journal of Structural Biology. 156: 497-504. PMID 16837211 DOI: 10.1016/J.Jsb.2006.05.003  0.323
2006 Tu DC, Owens LA, Anderson L, Golczak M, Doyle SE, McCall M, Menaker M, Palczewski K, Van Gelder RN. Inner retinal photoreception independent of the visual retinoid cycle. Proceedings of the National Academy of Sciences of the United States of America. 103: 10426-31. PMID 16788071 DOI: 10.1073/Pnas.0600917103  0.462
2006 Zhu L, Imanishi Y, Filipek S, Alekseev A, Jastrzebska B, Sun W, Saperstein DA, Palczewski K. Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene. The Journal of Biological Chemistry. 281: 22289-98. PMID 16737970 DOI: 10.1074/Jbc.M602664200  0.713
2006 Williams ML, Coleman JE, Haire SE, Aleman TS, Cideciyan AV, Sokal I, Palczewski K, Jacobson SG, Semple-Rowland SL. Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness. Plos Medicine. 3: e201. PMID 16700630 DOI: 10.1371/Journal.Pmed.0030201  0.429
2006 Stephen R, Palczewski K, Sousa MC. The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies. Journal of Molecular Biology. 359: 266-75. PMID 16626734 DOI: 10.1016/J.Jmb.2006.03.042  0.374
2006 Fotiadis D, Jastrzebska B, Philippsen A, Müller DJ, Palczewski K, Engel A. Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors Current Opinion in Structural Biology. 16: 252-259. PMID 16567090 DOI: 10.1016/J.Sbi.2006.03.013  0.344
2006 Maeda A, Maeda T, Imanishi Y, Golczak M, Moise AR, Palczewski K. Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters. Biochemistry. 45: 4210-9. PMID 16566595 DOI: 10.1021/Bi052382X  0.73
2006 Tanuj Sapra K, Park PSH, Filipek S, Engel A, Müller DJ, Palczewski K. Detecting molecular interactions that stabilize native bovine rhodopsin Journal of Molecular Biology. 358: 255-269. PMID 16519899 DOI: 10.1016/J.Jmb.2006.02.008  0.321
2005 Zhang L, Salom D, He J, Okun A, Ballesteros J, Palczewski K, Li N. Expression of functional G protein-coupled receptors in photoreceptors of transgenic Xenopus laevis. Biochemistry. 44: 14509-18. PMID 16262251 DOI: 10.1021/Bi051386Z  0.392
2005 Batten ML, Imanishi Y, Tu DC, Doan T, Zhu L, Pang J, Glushakova L, Moise AR, Baehr W, Van Gelder RN, Hauswirth WW, Rieke F, Palczewski K. Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. Plos Medicine. 2: e333. PMID 16250670 DOI: 10.1371/Journal.Pmed.0020333  0.723
2005 Maeda T, Lem J, Palczewski K, Haeseleer F. A critical role of CaBP4 in the cone synapse. Investigative Ophthalmology & Visual Science. 46: 4320-7. PMID 16249514 DOI: 10.1167/Iovs.05-0478  0.362
2005 Acland GM, Aguirre GD, Bennett J, Aleman TS, Cideciyan AV, Bennicelli J, Dejneka NS, Pearce-Kelling SE, Maguire AM, Palczewski K, Hauswirth WW, Jacobson SG. Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 1072-82. PMID 16226919 DOI: 10.1016/J.Ymthe.2005.08.008  0.458
2005 Golczak M, Imanishi Y, Kuksa V, Maeda T, Kubota R, Palczewski K. Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle. The Journal of Biological Chemistry. 280: 42263-73. PMID 16216874 DOI: 10.1074/Jbc.M509351200  0.696
2005 Bartl FJ, Fritze O, Ritter E, Herrmann R, Kuksa V, Palczewski K, Hofmann KP, Ernst OP. Partial agonism in a G Protein-coupled receptor: role of the retinal ring structure in rhodopsin activation. The Journal of Biological Chemistry. 280: 34259-67. PMID 16027155 DOI: 10.1074/Jbc.M505260200  0.445
2005 Stenkamp RE, Teller DC, Palczewski K. Rhodopsin: a structural primer for G-protein coupled receptors. Archiv Der Pharmazie. 338: 209-16. PMID 15952240 DOI: 10.1002/Ardp.200400995  0.353
2005 Jacobson SG, Aleman TS, Cideciyan AV, Sumaroka A, Schwartz SB, Windsor EA, Traboulsi EI, Heon E, Pittler SJ, Milam AH, Maguire AM, Palczewski K, Stone EM, Bennett J. Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success. Proceedings of the National Academy of Sciences of the United States of America. 102: 6177-82. PMID 15837919 DOI: 10.1073/Pnas.0500646102  0.436
2005 Sokal I, Dupps WJ, Grassi MA, Brown J, Affatigato LM, Roychowdhury N, Yang L, Filipek S, Palczewski K, Stone EM, Baehr W. A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD). Investigative Ophthalmology & Visual Science. 46: 1124-32. PMID 15790869 DOI: 10.1167/Iovs.04-1431  0.302
2005 Suda K, Filipek S, Palczewski K, Engel A, Fotiadis D. The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes. Molecular Membrane Biology. 21: 435-46. PMID 15764373 DOI: 10.1080/09687860400020291  0.328
2005 Maeda A, Maeda T, Imanishi Y, Kuksa V, Alekseev A, Bronson JD, Zhang H, Zhu L, Sun W, Saperstein DA, Rieke F, Baehr W, Palczewski K. Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. The Journal of Biological Chemistry. 280: 18822-32. PMID 15755727 DOI: 10.1074/Jbc.M501757200  0.746
2005 Kim TS, Maeda A, Maeda T, Heinlein C, Kedishvili N, Palczewski K, Nelson PS. Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo. The Journal of Biological Chemistry. 280: 8694-704. PMID 15634683 DOI: 10.1074/Jbc.M413172200  0.423
2005 Mammen A, Simpson PJ, Nighorn A, Imanishi Y, Palczewski K, Ronnett GV, Moon C. Corrigendum to “Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling” [Biochem. Biophys. Res. Commun. 322 (2004) 1131–1139] Biochemical and Biophysical Research Communications. 326: 695. DOI: 10.1016/J.Bbrc.2004.11.082  0.611
2004 Park PSH, Filipek S, Wells JW, Palczewski K. Oligomerization of G protein-coupled receptors: Past, present, and future Biochemistry. 43: 15643-15656. PMID 15595821 DOI: 10.1021/Bi047907K  0.305
2004 Jastrzebska B, Maeda T, Zhu L, Fotiadis D, Filipek S, Engel A, Stenkamp RE, Palczewski K. Functional characterization of rhodopsin monomers and dimers in detergents. The Journal of Biological Chemistry. 279: 54663-75. PMID 15489507 DOI: 10.1074/Jbc.M408691200  0.359
2004 Imanishi Y, Yang L, Sokal I, Filipek S, Palczewski K, Baehr W. Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes). Journal of Molecular Evolution. 59: 204-17. PMID 15486694 DOI: 10.1007/S00239-004-2614-Y  0.687
2004 Tu DC, Batten ML, Palczewski K, Van Gelder RN. Nonvisual photoreception in the chick iris. Science (New York, N.Y.). 306: 129-31. PMID 15459395 DOI: 10.1126/Science.1101484  0.397
2004 Zhu L, Jang GF, Jastrzebska B, Filipek S, Pearce-Kelling SE, Aguirre GD, Stenkamp RE, Acland GM, Palczewski K. A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor. The Journal of Biological Chemistry. 279: 53828-39. PMID 15459196 DOI: 10.1074/Jbc.M408472200  0.43
2004 Haeseleer F, Imanishi Y, Maeda T, Possin DE, Maeda A, Lee A, Rieke F, Palczewski K. Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nature Neuroscience. 7: 1079-87. PMID 15452577 DOI: 10.1038/Nn1320  0.665
2004 Moise AR, Kuksa V, Imanishi Y, Palczewski K. Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. The Journal of Biological Chemistry. 279: 50230-42. PMID 15358783 DOI: 10.1074/Jbc.M409130200  0.675
2004 Liang Y, Fotiadis D, Maeda T, Maeda A, Modzelewska A, Filipek S, Saperstein DA, Engel A, Palczewski K. Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice. The Journal of Biological Chemistry. 279: 48189-96. PMID 15337746 DOI: 10.1074/Jbc.M408362200  0.349
2004 Mammen A, Simpson PJ, Mamman A, Simpson JP, Nighorn A, Imanishi Y, Palczewski K, Ronnett GV, Moon C. Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling. Biochemical and Biophysical Research Communications. 322: 1131-9. PMID 15336960 DOI: 10.1016/J.Bbrc.2004.07.123  0.642
2004 Palczewski K, Sokal I, Baehr W. Guanylate cyclase-activating proteins: structure, function, and diversity. Biochemical and Biophysical Research Communications. 322: 1123-30. PMID 15336959 DOI: 10.1016/J.Bbrc.2004.07.122  0.366
2004 Imanishi Y, Gerke V, Palczewski K. Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. The Journal of Cell Biology. 166: 447-53. PMID 15314061 DOI: 10.1083/Jcb.200405110  0.677
2004 Filipek S, Krzysko KA, Fotiadis D, Liang Y, Saperstein DA, Engel A, Palczewski K. A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society For Photobiology. 3: 628-38. PMID 15170495 DOI: 10.1039/B315661C  0.318
2004 Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K. The G protein-coupled receptor rhodopsin in the native membrane. Febs Letters. 564: 281-288. PMID 15111110 DOI: 10.1016/S0014-5793(04)00194-2  0.312
2004 Aleman TS, Jacobson SG, Chico JD, Scott ML, Cheung AY, Windsor EA, Furushima M, Redmond TM, Bennett J, Palczewski K, Cideciyan AV. Impairment of the transient pupillary light reflex in Rpe65(-/-) mice and humans with leber congenital amaurosis. Investigative Ophthalmology & Visual Science. 45: 1259-71. PMID 15037595 DOI: 10.1167/Iovs.03-1230  0.398
2004 Imanishi Y, Batten ML, Piston DW, Baehr W, Palczewski K. Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. The Journal of Cell Biology. 164: 373-83. PMID 14745001 DOI: 10.1083/Jcb.200311079  0.749
2004 Batten ML, Imanishi Y, Maeda T, Tu DC, Moise AR, Bronson D, Possin D, Van Gelder RN, Baehr W, Palczewski K. Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver. The Journal of Biological Chemistry. 279: 10422-32. PMID 14684738 DOI: 10.1074/Jbc.M312410200  0.733
2003 Teller DC, Stenkamp RE, Palczewski K. Evolutionary analysis of rhodopsin and cone pigments: connecting the three-dimensional structure with spectral tuning and signal transfer. Febs Letters. 555: 151-9. PMID 14630336 DOI: 10.1016/S0014-5793(03)01152-9  0.377
2003 Kuksa V, Imanishi Y, Batten M, Palczewski K, Moise AR. Retinoid cycle in the vertebrate retina: experimental approaches and mechanisms of isomerization. Vision Research. 43: 2959-81. PMID 14611933 DOI: 10.1016/S0042-6989(03)00482-6  0.698
2003 Baehr W, Wu SM, Bird AC, Palczewski K. The retinoid cycle and retina disease. Vision Research. 43: 2957-8. PMID 14611932 DOI: 10.1016/J.Visres.2003.10.001  0.337
2003 Ridge KD, Abdulaev NG, Sousa M, Palczewski K. Phototransduction: Crystal clear Trends in Biochemical Sciences. 28: 479-487. PMID 13678959 DOI: 10.1016/S0968-0004(03)00172-5  0.333
2003 Maeda T, Imanishi Y, Palczewski K. Rhodopsin phosphorylation: 30 years later. Progress in Retinal and Eye Research. 22: 417-34. PMID 12742390 DOI: 10.1016/S1350-9462(03)00017-X  0.672
2003 Schadel SA, Heck M, Maretzki D, Filipek S, Teller DC, Palczewski K, Hofmann KP. Ligand channeling within a G-protein-coupled receptor. The entry and exit of retinals in native opsin. The Journal of Biological Chemistry. 278: 24896-903. PMID 12707280 DOI: 10.1074/Jbc.M302115200  0.434
2003 Liang Y, Fotiadis D, Filipek S, Saperstein DA, Palczewski K, Engel A. Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. The Journal of Biological Chemistry. 278: 21655-21662. PMID 12663652 DOI: 10.1074/Jbc.M302536200  0.38
2003 Fritze O, Filipek S, Kuksa V, Palczewski K, Hofmann KP, Ernst OP. Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation. Proceedings of the National Academy of Sciences of the United States of America. 100: 2290-5. PMID 12601165 DOI: 10.1073/Pnas.0435715100  0.355
2003 Filipek S, Teller DC, Palczewski K, Stenkamp R. The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors. Annual Review of Biophysics and Biomolecular Structure. 32: 375-97. PMID 12574068 DOI: 10.1146/Annurev.Biophys.32.110601.142520  0.354
2003 Noorwez SM, Kuksa V, Imanishi Y, Zhu L, Filipek S, Palczewski K, Kaushal S. Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa. The Journal of Biological Chemistry. 278: 14442-50. PMID 12566452 DOI: 10.1074/Jbc.M300087200  0.721
2003 Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K. Atomic-force microscopy: Rhodopsin dimers in native disc membranes. Nature. 421: 127-8. PMID 12520290 DOI: 10.1038/421127A  0.369
2003 Sokal I, Hu G, Liang Y, Mao M, Wensel TG, Palczewski K. Identification of protein kinase C isozymes responsible for the phosphorylation of photoreceptor-specific RGS9-1 at Ser475. The Journal of Biological Chemistry. 278: 8316-25. PMID 12499365 DOI: 10.1074/Jbc.M211782200  0.368
2003 Filipek S, Stenkamp RE, Teller DC, Palczewski K. G protein-coupled receptor rhodopsin: a prospectus. Annual Review of Physiology. 65: 851-79. PMID 12471166 DOI: 10.1146/Annurev.Physiol.65.092101.142611  0.43
2003 Heck M, Schädel SA, Maretzki D, Bartl FJ, Ritter E, Palczewski K, Hofmann KP. Signaling states of rhodopsin. Formation of the storage form, metarhodopsin III, from active metarhodopsin II. The Journal of Biological Chemistry. 278: 3162-9. PMID 12427735 DOI: 10.1074/Jbc.M209675200  0.409
2003 Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K. Is rhodopsin dimeric in native retinal rods? Nature. 426: 31-31. DOI: 10.1038/426031A  0.443
2002 Stenkamp RE, Filipek S, Driessen CA, Teller DC, Palczewski K. Crystal structure of rhodopsin: a template for cone visual pigments and other G protein-coupled receptors. Biochimica Et Biophysica Acta. 1565: 168-82. PMID 12409193 DOI: 10.1016/S0005-2736(02)00567-9  0.415
2002 Haeseleer F, Jang GF, Imanishi Y, Driessen CA, Matsumura M, Nelson PS, Palczewski K. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. The Journal of Biological Chemistry. 277: 45537-46. PMID 12226107 DOI: 10.1074/Jbc.M208882200  0.736
2002 Maeda A, Maeda T, Ohguro H, Palczewski K, Sato N. Vaccination with recoverin, a cancer-associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice. European Journal of Immunology. 32: 2300-7. PMID 12209643 DOI: 10.1002/1521-4141(200208)32:8<2300::Aid-Immu2300>3.0.Co;2-7  0.314
2002 Kuksa V, Bartl F, Maeda T, Jang GF, Ritter E, Heck M, Van Hooser JP, Liang Y, Filipek S, Gelb MH, Hofmann KP, Palczewski K. Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals. The Journal of Biological Chemistry. 277: 42315-24. PMID 12176994 DOI: 10.1074/Jbc.M206014200  0.431
2002 Howes KA, Pennesi ME, Sokal I, Church-Kopish J, Schmidt B, Margolis D, Frederick JM, Rieke F, Palczewski K, Wu SM, Detwiler PB, Baehr W. GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice. The Embo Journal. 21: 1545-54. PMID 11927539 DOI: 10.1093/Emboj/21.7.1545  0.373
2002 Van Hooser JP, Liang Y, Maeda T, Kuksa V, Jang GF, He YG, Rieke F, Fong HK, Detwiler PB, Palczewski K. Recovery of visual functions in a mouse model of Leber congenital amaurosis. The Journal of Biological Chemistry. 277: 19173-82. PMID 11897783 DOI: 10.1074/Jbc.M112384200  0.5
2002 Imanishi Y, Li N, Sokal I, Sowa ME, Lichtarge O, Wensel TG, Saperstein DA, Baehr W, Palczewski K. Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. The European Journal of Neuroscience. 15: 63-78. PMID 11860507 DOI: 10.1046/J.0953-816X.2001.01835.X  0.712
2002 Haeseleer F, Imanishi Y, Sokal I, Filipek S, Palczewski K. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochemical and Biophysical Research Communications. 290: 615-23. PMID 11785943 DOI: 10.1006/Bbrc.2001.6228  0.662
2001 Haeseleer F, Imanishi Y, Saperstein DA, Palczewski K. Gene transfer mediated by recombinant baculovirus into mouse eye. Investigative Ophthalmology & Visual Science. 42: 3294-300. PMID 11726636  0.605
2001 McBee JK, Van Hooser JP, Jang GF, Palczewski K. Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo. The Journal of Biological Chemistry. 276: 48483-93. PMID 11604395 DOI: 10.1074/Jbc.M105840200  0.823
2001 Okada T, Palczewski K. Crystal structure of rhodopsin: implications for vision and beyond Current Opinion in Structural Biology. 11: 420-426. PMID 11495733 DOI: 10.1016/S0959-440X(00)00227-X  0.474
2001 Mendez A, Burns ME, Sokal I, Dizhoor AM, Baehr W, Palczewski K, Baylor DA, Chen J. Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors. Proceedings of the National Academy of Sciences of the United States of America. 98: 9948-53. PMID 11493703 DOI: 10.1073/Pnas.171308998  0.387
2001 Teller DC, Okada T, Behnke CA, Palczewski K, Stenkamp RE. Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry. 40: 7761-72. PMID 11425302 DOI: 10.1021/Bi0155091  0.36
2001 Jang GF, Van Hooser JP, Kuksa V, McBee JK, He YG, Janssen JJ, Driessen CA, Palczewski K. Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus. The Journal of Biological Chemistry. 276: 32456-65. PMID 11418621 DOI: 10.1074/Jbc.M104949200  0.82
2001 Yan W, Jang GF, Haeseleer F, Esumi N, Chang J, Kerrigan M, Campochiaro M, Campochiaro P, Palczewski K, Zack DJ. Cloning and characterization of a human beta,beta-carotene-15,15'-dioxygenase that is highly expressed in the retinal pigment epithelium. Genomics. 72: 193-202. PMID 11401432 DOI: 10.1006/Geno.2000.6476  0.357
2001 McBee JK, Palczewski K, Baehr W, Pepperberg DR. Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina. Progress in Retinal and Eye Research. 20: 469-529. PMID 11390257 DOI: 10.1016/S1350-9462(01)00002-7  0.837
2001 Jang GF, Kuksa V, Filipek S, Bartl F, Ritter E, Gelb MH, Hofmann KP, Palczewski K. Mechanism of rhodopsin activation as examined with ring-constrained retinal analogs and the crystal structure of the ground state protein. The Journal of Biological Chemistry. 276: 26148-53. PMID 11316815 DOI: 10.1074/Jbc.M102212200  0.447
2001 Hu G, Jang GF, Cowan CW, Wensel TG, Palczewski K. Phosphorylation of RGS9-1 by an endogenous protein kinase in rod outer segments. The Journal of Biological Chemistry. 276: 22287-95. PMID 11292825 DOI: 10.1074/Jbc.M011539200  0.315
2000 Cideciyan AV, Haeseleer F, Fariss RN, Aleman TS, Jang GF, Verlinde CL, Marmor MF, Jacobson SG, Palczewski K. Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man. Visual Neuroscience. 17: 667-78. PMID 11153648 DOI: 10.1017/S0952523800175029  0.468
2000 Sokal I, Li N, Verlinde CL, Haeseleer F, Baehr W, Palczewski K. Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). Biochimica Et Biophysica Acta. 1498: 233-51. PMID 11108966 DOI: 10.1016/S0167-4889(00)00099-9  0.401
2000 Imamoto Y, Kataoka M, Tokunaga F, Palczewski K. Light-induced conformational changes of rhodopsin probed by fluorescent alexa594 immobilized on the cytoplasmic surface. Biochemistry. 39: 15225-15233. PMID 11106502 DOI: 10.1021/Bi0018685  0.515
2000 McBee JK, Kuksa V, Alvarez R, de Lera AR, Prezhdo O, Haeseleer F, Sokal I, Palczewski K. Isomerization of all-trans-retinol to cis-retinols in bovine retinal pigment epithelial cells: dependence on the specificity of retinoid-binding proteins. Biochemistry. 39: 11370-80. PMID 10985782 DOI: 10.1021/Bi001061C  0.835
2000 Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, Le Trong I, Teller DC, Okada T, Stenkamp RE, Yamamoto M, Miyano M. Crystal structure of rhodopsin: A G protein-coupled receptor. Science (New York, N.Y.). 289: 739-45. PMID 10926528 DOI: 10.1126/Science.289.5480.739  0.365
2000 Jang GF, McBee JK, Alekseev AM, Haeseleer F, Palczewski K. Stereoisomeric specificity of the retinoid cycle in the vertebrate retina. The Journal of Biological Chemistry. 275: 28128-38. PMID 10871622 DOI: 10.1074/Jbc.M004488200  0.826
2000 Van Hooser JP, Aleman TS, He YG, Cideciyan AV, Kuksa V, Pittler SJ, Stone EM, Jacobson SG, Palczewski K. Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proceedings of the National Academy of Sciences of the United States of America. 97: 8623-8. PMID 10869443 DOI: 10.1073/Pnas.150236297  0.468
2000 Driessen CA, Winkens HJ, Hoffmann K, Kuhlmann LD, Janssen BP, Van Vugt AH, Van Hooser JP, Wieringa BE, Deutman AF, Palczewski K, Ruether K, Janssen JJ. Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters. Molecular and Cellular Biology. 20: 4275-87. PMID 10825191 DOI: 10.1128/Mcb.20.12.4275-4287.2000  0.382
2000 Okada T, Le Trong I, Fox BA, Behnke CA, Stenkamp RE, Palczewski K. X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles. Journal of Structural Biology. 130: 73-80. PMID 10806093 DOI: 10.1006/Jsbi.1999.4209  0.335
2000 Whitten ME, Yokoyama K, Schieltz D, Ghomashchi F, Lam D, Yates JR, Palczewski K, Gelb MH. Structural analysis of protein prenyl groups and associated C-terminal modifications. Methods in Enzymology. 316: 436-51. PMID 10800693 DOI: 10.1016/S0076-6879(00)16741-2  0.319
2000 Saari JC, Garwin GG, Haeseleer F, Jang GF, Palczewski K. Phase partition and high-performance liquid chromatography assays of retinoid dehydrogenases Methods in Enzymology. 316: 359-371. PMID 10800687 DOI: 10.1016/S0076-6879(00)16735-7  0.397
2000 Stecher H, Palczewski K. Multienzyme analysis of visual cycle. Methods in Enzymology. 316: 330-44. PMID 10800685 DOI: 10.1016/S0076-6879(00)16733-3  0.475
2000 Palczewski K, Polans AS, Baehr W, Ames JB. Ca2+-binding proteins in the retina: Structure, function, and the etiology of human visual diseases Bioessays. 22: 337-350. PMID 10723031 DOI: 10.1002/(Sici)1521-1878(200004)22:4<337::Aid-Bies4>3.0.Co;2-Z  0.383
1999 Zhang K, Howes KA, He W, Bronson JD, Pettenati MJ, Chen C, Palczewski K, Wensel TG, Baehr W. Structure, alternative splicing, and expression of the human RGS9 gene. Gene. 240: 23-34. PMID 10564809 DOI: 10.1016/S0378-1119(99)00393-5  0.387
1999 Stecher H, Prezhdo O, Das J, Crouch RK, Palczewski K. Isomerization of all-trans-9- and 13-desmethylretinol by retinal pigment epithelial cells. Biochemistry. 38: 13542-50. PMID 10521261 DOI: 10.1021/Bi9913294  0.378
1999 Zhao X, Yokoyama K, Whitten ME, Huang J, Gelb MH, Palczewski K. A novel form of rhodopsin kinase from chicken retina and pineal gland. Febs Letters. 454: 115-21. PMID 10413107 DOI: 10.1016/S0014-5793(99)00764-4  0.593
1999 Sokal I, Otto-Bruc AE, Surgucheva I, Verlinde CL, Wang CK, Baehr W, Palczewski K. Conformational changes in guanylyl cyclase-activating protein 1 (GCAP1) and its tryptophan mutants as a function of calcium concentration. The Journal of Biological Chemistry. 274: 19829-37. PMID 10391927 DOI: 10.1074/Jbc.274.28.19829  0.311
1999 Ames JB, Dizhoor AM, Ikura M, Palczewski K, Stryer L. Three-dimensional structure of guanylyl cyclase activating protein-2, a calcium-sensitive modulator of photoreceptor guanylyl cyclases. The Journal of Biological Chemistry. 274: 19329-37. PMID 10383444 DOI: 10.1074/Jbc.274.27.19329  0.352
1999 Stecher H, Gelb MH, Saari JC, Palczewski K. Preferential release of 11-cis-retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde-binding protein. The Journal of Biological Chemistry. 274: 8577-85. PMID 10085092 DOI: 10.1074/Jbc.274.13.8577  0.439
1999 Wolbring G, Baehr W, Palczewski K, Schnetkamp PPM. Light inhibition of bovine retinal rod guanylyl cyclase mediated by βγ-transducin Biochemistry. 38: 2611-2616. PMID 10052930 DOI: 10.1021/Bi9825596  0.371
1998 Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K. Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. The Journal of Biological Chemistry. 273: 21790-9. PMID 9705317 DOI: 10.1074/Jbc.273.34.21790  0.472
1998 Sokal I, Li N, Surgucheva I, Warren MJ, Payne AM, Bhattacharya SS, Baehr W, Palczewski K. GCAP1(Y99C) mutant is constitutively active in autosomal dominant cone dystrophy Molecular Cell. 2: 129-133. PMID 9702199 DOI: 10.1016/S1097-2765(00)80121-5  0.372
1998 Cowan CW, Fariss RN, Sokal I, Palczewski K, Wensel TG. High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proceedings of the National Academy of Sciences of the United States of America. 95: 5351-6. PMID 9560279 DOI: 10.1073/Pnas.95.9.5351  0.381
1998 Li N, Fariss RN, Zhang K, Otto-Bruc A, Haeseleer F, Bronson D, Qin N, Yamazaki A, Subbaraya I, Milam AH, Palczewski K, Baehr W. Guanylate-cyclase-inhibitory protein is a frog retinal Ca2+-binding protein related to mammalian guanylate-cyclase-activating proteins European Journal of Biochemistry. 252: 591-599. PMID 9546678 DOI: 10.1046/J.1432-1327.1998.2520591.X  0.34
1998 Zhao X, Huang J, Khani SC, Palczewski K. Molecular forms of human rhodopsin kinase (GRK1). The Journal of Biological Chemistry. 273: 5124-31. PMID 9478965 DOI: 10.1074/Jbc.273.9.5124  0.613
1998 Semple-Rowland SL, Lee NR, Van Hooser JP, Palczewski K, Baehr W. A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype. Proceedings of the National Academy of Sciences of the United States of America. 95: 1271-6. PMID 9448321 DOI: 10.1073/Pnas.95.3.1271  0.447
1998 Cideciyan AV, Zhao X, Nielsen L, Khani SC, Jacobson SG, Palczewski K. Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. Proceedings of the National Academy of Sciences of the United States of America. 95: 328-33. PMID 9419375 DOI: 10.1073/Pnas.95.1.328  0.65
1997 Zhao X, Haeseleer F, Fariss RN, Huang J, Baehr W, Milam AH, Palczewski K. Molecular cloning and localization of rhodopsin kinase in the mammalian pineal. Visual Neuroscience. 14: 225-32. PMID 9147475 DOI: 10.1017/S0952523800011366  0.606
1997 Otto-Bruc A, Fariss RN, Haeseleer F, Huang J, Buczyłko J, Surgucheva I, Baehr W, Milam AH, Palczewski K. Localization of guanylate cyclase-activating protein 2 in mammalian retinas Proceedings of the National Academy of Sciences of the United States of America. 94: 4727-4732. PMID 9114059 DOI: 10.1073/Pnas.94.9.4727  0.404
1996 Polans A, Baehr W, Palczewski K. Turned on by Ca2+! The physiology and pathology of Ca2+-binding proteins in the retina Trends in Neurosciences. 19: 547-554. PMID 8961484 DOI: 10.1016/S0166-2236(96)10059-X  0.327
1996 Semple-Rowland SL, Gorczyca WA, Buczylko J, Helekar BS, Ruiz CC, Subbaraya I, Palczewski K, Baehr W. Expression of GCAP1 and GCAP2 in the retinal degeneration (rd) mutant chicken retina. Febs Letters. 385: 47-52. PMID 8641465 DOI: 10.1016/0014-5793(96)00345-6  0.431
1996 Ohguro H, Rudnicka-Nawrot M, Buczyłko J, Zhao X, Taylor JA, Walsh KA, Palczewski K. Structural and enzymatic aspects of rhodopsin phosphorylation. The Journal of Biological Chemistry. 271: 5215-24. PMID 8617805 DOI: 10.1074/Jbc.271.9.5215  0.54
1996 Jäger S, Palczewski K, Hofmann KP. Opsin/all-trans-retinal complex activates transducin by different mechanisms than photolyzed rhodopsin. Biochemistry. 35: 2901-2908. PMID 8608127 DOI: 10.1021/Bi9524068  0.462
1995 Gorczyca WA, Polans AS, Surgucheva IG, Subbaraya I, Baehr W, Palczewski K. Guanylyl cyclase activating protein: A calcium-sensitive regulator of phototransduction Journal of Biological Chemistry. 270: 22029-22036. PMID 7665624 DOI: 10.1074/Jbc.270.37.22029  0.386
1995 Zhao X, Palczewski K, Ohguro H. Mechanism of rhodopsin phosphorylation. Biophysical Chemistry. 56: 183-8. PMID 7662865 DOI: 10.1016/0301-4622(95)00031-R  0.559
1994 Ohguro H, Johnson RS, Ericsson LH, Walsh KA, Palczewski K. Control of rhodopsin multiple phosphorylation Biochemistry. 33: 1023-1028. PMID 8305429 DOI: 10.1021/Bi00170A022  0.306
1994 Palczewski K, Buczylko J, Ohguro H, Annan RS, Carr SA, Crabb JW, Kaplan MW, Johnson RS, Walsh KA. Characterization of a truncated form of arrestin isolated from bovine rod outer segments Protein Science. 3: 314-324. PMID 8003967 DOI: 10.1002/Pro.5560030215  0.327
1994 Subbaraya I, Ruiz CC, Helekar BS, Zhao X, Gorczyca WA, Pettenati MJ, Rao PN, Palczewski K, Baehr W. Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. The Journal of Biological Chemistry. 269: 31080-9. PMID 7983048  0.516
1994 Gorczyca WA, Gray-Keller MP, Detwiler PB, Palczewski K. Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods. Proceedings of the National Academy of Sciences of the United States of America. 91: 4014-8. PMID 7909609 DOI: 10.1073/Pnas.91.9.4014  0.391
1994 Palczewski K, Subbaraya I, Gorczyca WA, Helekar BS, Ruiz CC, Ohguro H, Huang J, Zhao X, Crabb JW, Johnson RS, Walsh KA, Gray-Keller MP, Detwiler PB, Baehr W. Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein Neuron. 13: 395-404. PMID 7520254 DOI: 10.1016/0896-6273(94)90355-7  0.586
1994 Gorczyca WA, Hooser JPV, Palczewski K. Nucleotide inhibitors and activators of retinal guanylyl cyclase. Biochemistry. 33: 3217-3222. PMID 7511001 DOI: 10.1021/Bi00177A011  0.421
1993 Gray-Keller MP, Polans AS, Palczewski K, Detwiler PB. The effect of recoverin-like calcium-binding proteins on the photoresponse of retinal rods. Neuron. 10: 523-31. PMID 8461139 DOI: 10.1016/0896-6273(93)90339-S  0.345
1993 Polans AS, Crabb JW, Palczewski K. Calcium-Binding Proteins in the Retina Methods in Neurosciences. 15: 248-260. DOI: 10.1016/B978-0-12-185279-5.50023-6  0.318
1993 Buczyłko J, Palczewski K. Purification of Arrestin from Bovine Retinas Methods in Neurosciences. 15: 226-236. DOI: 10.1016/B978-0-12-185279-5.50021-2  0.417
1993 Palczewski K. Purification of Rhodopsin Kinase from Bovine Rod Outer Segments Methods in Neurosciences. 15: 217-225. DOI: 10.1016/B978-0-12-185279-5.50020-0  0.364
1993 Crabb JW, Johnson C, West K, Buczylko J, Palczewski K, Hou J, McKeehan K, Kan M, McKeehan WL, Huddleston MJ, Carr SA. Analysis of Serine, Threonine and Tyrosine Phosphorylation Sites with Mass Spectrometry Techniques in Protein Chemistry. 171-178. DOI: 10.1016/B978-0-12-058757-5.50024-X  0.304
1992 Palczewski K, Rispoli G, Detwiler PB. The influence of arrestin (48K protein) and rhodopsin kinase on visual transduction. Neuron. 8: 117-26. PMID 1309646 DOI: 10.1016/0896-6273(92)90113-R  0.369
1991 Polans AS, Buczyłko J, Crabb J, Palczewski K. A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy Journal of Cell Biology. 112: 981-989. PMID 1999465 DOI: 10.1083/Jcb.112.5.981  0.405
1991 Palczewski K, Farber DB, Hargrave PA. Elevated level of protein phosphatase 2A activity in retinas of rd mice. Experimental Eye Research. 53: 101-5. PMID 1652453 DOI: 10.1016/0014-4835(91)90151-4  0.393
1990 Palczewski K, Carruth ME, Adamus G, McDowell JH, Hargrave PA. Molecular, enzymatic and functional properties of rhodopsin kinase from rat pineal gland. Vision Research. 30: 1129-37. PMID 2402884 DOI: 10.1016/0042-6989(90)90170-P  0.335
1990 Fukada Y, Kokame K, Okano T, Shichida Y, Yoshizawa T, McDowell JH, Hargrave PA, Palczewski K. Phosphorylation of iodopsin, chicken red-sensitive cone visual pigment. Biochemistry. 29: 10102-10106. PMID 2271641 DOI: 10.1021/Bi00495A013  0.397
1989 Palczewski K, Hargrave PA, McDowell JH, Ingebritsen TS. The catalytic subunit of phosphatase 2A dephosphorylates phosphoopsin. Biochemistry. 28: 415-419. PMID 2540796 DOI: 10.1021/Bi00428A001  0.31
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