Richard W. Tsien - Publications

Affiliations: 
New York University School of Medicine, New York, NY, United States 
 Stanford University, Palo Alto, CA 
Area:
calcium channel physiology and function in heart and neurons

271 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Tirko NN, Eyring KW, Carcea I, Mitre M, Chao MV, Froemke RC, Tsien RW. Oxytocin Transforms Firing Mode of CA2 Hippocampal Neurons. Neuron. PMID 30293821 DOI: 10.1016/j.neuron.2018.09.008  1
2018 Cohen SM, Suutari B, He X, Wang Y, Sanchez S, Tirko NN, Mandelberg NJ, Mullins C, Zhou G, Wang S, Kats I, Salah A, Tsien RW, Ma H. Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory. Nature Communications. 9: 2451. PMID 29934532 DOI: 10.1038/s41467-018-04705-8  1
2018 Eyring KW, Tsien RW. Direct Visualization of Wide Fusion-Fission Pores and Their Highly Varied Dynamics. Cell. 173: 819-821. PMID 29727670 DOI: 10.1016/j.cell.2018.04.016  0.4
2016 Rink TJ, Tsien LY, Tsien RW. Roger Yonchien Tsien (1952-2016). Nature. 538: 172. PMID 27734865 DOI: 10.1038/538172a  1
2016 Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW, Fishell G, Mullins C, Gonçalves JT, Shtrahman M, Johnston ST, Gage FH, et al. What is memory? The present state of the engram. Bmc Biology. 14: 40. PMID 27197636 DOI: 10.1186/s12915-016-0261-6  1
2016 Cohen SM, Ma H, Kuchibhotla KV, Watson BO, Buzsáki G, Froemke RC, Tsien RW. Excitation-Transcription Coupling in Parvalbumin-Positive Interneurons Employs a Novel CaM Kinase-Dependent Pathway Distinct from Excitatory Neurons. Neuron. PMID 27041500 DOI: 10.1016/j.neuron.2016.03.001  1
2016 Mullins C, Fishell G, Tsien RW. Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops. Neuron. 89: 1131-56. PMID 26985722 DOI: 10.1016/j.neuron.2016.02.017  1
2016 Li B, Tadross MR, Tsien RW. Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression. Science (New York, N.Y.). 351: 863-7. PMID 26912895 DOI: 10.1126/science.aad3647  1
2015 Cohen SM, Li B, Tsien RW, Ma H. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus. Biochemical and Biophysical Research Communications. 460: 88-99. PMID 25998737 DOI: 10.1016/j.bbrc.2015.02.146  1
2015 Shen Y, Ge WP, Li Y, Hirano A, Lee HY, Rohlmann A, Missler M, Tsien RW, Jan LY, Fu YH, Ptá?ek LJ. Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis. Proceedings of the National Academy of Sciences of the United States of America. 112: 2935-41. PMID 25730884 DOI: 10.1073/pnas.1501364112  1
2015 Ma H, Li B, Tsien RW. Distinct roles of multiple isoforms of CaMKII in signaling to the nucleus. Biochimica Et Biophysica Acta. PMID 25700840 DOI: 10.1016/j.bbamcr.2015.02.008  1
2015 Cohen SM, Tsien RW, Goff DC, Halassa MM. The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia. Schizophrenia Research. PMID 25583246 DOI: 10.1016/j.schres.2014.12.026  1
2015 Rosenberg EC, Tsien RW, Whalley BJ, Devinsky O. Cannabinoids and Epilepsy Neurotherapeutics. DOI: 10.1007/s13311-015-0375-5  1
2014 Ma H, Groth RD, Cohen SM, Emery JF, Li B, Hoedt E, Zhang G, Neubert TA, Tsien RW. γCaMKII shuttles Ca²⁺/CaM to the nucleus to trigger CREB phosphorylation and gene expression. Cell. 159: 281-94. PMID 25303525 DOI: 10.1016/j.cell.2014.09.019  1
2014 Peng H, Tang J, Xiao H, Bria A, Zhou J, Butler V, Zhou Z, Gonzalez-Bellido PT, Oh SW, Chen J, Mitra A, Tsien RW, Zeng H, Ascoli GA, Iannello G, et al. Virtual finger boosts three-dimensional imaging and microsurgery as well as terabyte volume image visualization and analysis. Nature Communications. 5: 4342. PMID 25014658 DOI: 10.1038/ncomms5342  0.6
2014 Groth RD, Tirko NN, Tsien RW. CaV1.2 calcium channels: just cut out to be regulated? Neuron. 82: 939-40. PMID 24908477 DOI: 10.1016/j.neuron.2014.05.030  1
2014 Karayannis T, Au E, Patel JC, Kruglikov I, Markx S, Delorme R, Héron D, Salomon D, Glessner J, Restituito S, Gordon A, Rodriguez-Murillo L, Roy NC, Gogos JA, Rudy B, ... ... Tsien RW, et al. Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission. Nature. 511: 236-40. PMID 24870235 DOI: 10.1038/nature13248  0.88
2013 Tadross MR, Tsien RW, Yue DT. Ca2+ channel nanodomains boost local Ca2+ amplitude. Proceedings of the National Academy of Sciences of the United States of America. 110: 15794-9. PMID 24019485 DOI: 10.1073/pnas.1313898110  1
2013 Liang L, Li Y, Potter CJ, Yizhar O, Deisseroth K, Tsien RW, Luo L. GABAergic projection neurons route selective olfactory inputs to specific higher-order neurons. Neuron. 79: 917-31. PMID 24012005 DOI: 10.1016/j.neuron.2013.06.014  1
2013 Lee S, Song B, Kim J, Park K, Hong I, An B, Song S, Lee J, Park S, Kim J, Park D, Lee CJ, Kim K, Shin KS, Tsien RW, et al. GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal. Nature Neuroscience. 16: 1436-44. PMID 23974710 DOI: 10.1038/nn.3491  1
2013 Owen SF, Tuncdemir SN, Bader PL, Tirko NN, Fishell G, Tsien RW. Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons. Nature. 500: 458-62. PMID 23913275 DOI: 10.1038/nature12330  1
2013 Hong I, Kim J, Kim J, Lee S, Ko HG, Nader K, Kaang BK, Tsien RW, Choi S. AMPA receptor exchange underlies transient memory destabilization on retrieval. Proceedings of the National Academy of Sciences of the United States of America. 110: 8218-23. PMID 23630279 DOI: 10.1073/pnas.1305235110  1
2013 Alabi AA, Tsien RW. Perspectives on kiss-and-run: role in exocytosis, endocytosis, and neurotransmission. Annual Review of Physiology. 75: 393-422. PMID 23245563 DOI: 10.1146/annurev-physiol-020911-153305  1
2013 Ma H, Cohen S, Li B, Tsien RW. Exploring the dominant role of Cav1 channels in signalling to the nucleus. Bioscience Reports. 33: 97-101. PMID 23088728 DOI: 10.1042/BSR20120099  1
2012 Alabi AA, Tsien RW. Synaptic vesicle pools and dynamics. Cold Spring Harbor Perspectives in Biology. 4: a013680. PMID 22745285 DOI: 10.1101/cshperspect.a013680  1
2012 Li Y, Tsien RW. pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity. Nature Neuroscience. 15: 1047-53. PMID 22634730 DOI: 10.1038/nn.3126  1
2012 Wheeler DG, Groth RD, Ma H, Barrett CF, Owen SF, Safa P, Tsien RW. Ca(V)1 and Ca(V)2 channels engage distinct modes of Ca(2+) signaling to control CREB-dependent gene expression. Cell. 149: 1112-24. PMID 22632974 DOI: 10.1016/j.cell.2012.03.041  1
2012 Kim J, Tsien RW, Alger BE. An improved test for detecting multiplicative homeostatic synaptic scaling. Plos One. 7: e37364. PMID 22615990 DOI: 10.1371/journal.pone.0037364  1
2012 Park H, Li Y, Tsien RW. Influence of synaptic vesicle position on release probability and exocytotic fusion mode. Science (New York, N.Y.). 335: 1362-6. PMID 22345401 DOI: 10.1126/science.1216937  1
2012 Mitra A, Mitra SS, Tsien RW. Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity. Nature Neuroscience. 15: 250-7. PMID 22179109 DOI: 10.1038/nn.3004  1
2011 Bader PL, Faizi M, Kim LH, Owen SF, Tadross MR, Alfa RW, Bett GC, Tsien RW, Rasmusson RL, Shamloo M. Mouse model of Timothy syndrome recapitulates triad of autistic traits. Proceedings of the National Academy of Sciences of the United States of America. 108: 15432-7. PMID 21878566 DOI: 10.1073/pnas.1112667108  1
2011 Yoo AS, Sun AX, Li L, Shcheglovitov A, Portmann T, Li Y, Lee-Messer C, Dolmetsch RE, Tsien RW, Crabtree GR. MicroRNA-mediated conversion of human fibroblasts to neurons. Nature. 476: 228-31. PMID 21753754 DOI: 10.1038/nature10323  1
2011 Faizi M, Bader PL, Tun C, Encarnacion A, Kleschevnikov A, Belichenko P, Saw N, Priestley M, Tsien RW, Mobley WC, Shamloo M. Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiology of Disease. 43: 397-413. PMID 21527343 DOI: 10.1016/j.nbd.2011.04.011  0.88
2011 Ma H, Groth RD, Wheeler DG, Barrett CF, Tsien RW. Excitation-transcription coupling in sympathetic neurons and the molecular mechanism of its initiation. Neuroscience Research. 70: 2-8. PMID 21352861 DOI: 10.1016/j.neures.2011.02.004  1
2011 Groth RD, Lindskog M, Thiagarajan TC, Li L, Tsien RW. Beta Ca2+/CaM-dependent kinase type II triggers upregulation of GluA1 to coordinate adaptation to synaptic inactivity in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 108: 828-33. PMID 21187407 DOI: 10.1073/pnas.1018022108  1
2010 Lindskog M, Li L, Groth RD, Poburko D, Thiagarajan TC, Han X, Tsien RW. Postsynaptic GluA1 enables acute retrograde enhancement of presynaptic function to coordinate adaptation to synaptic inactivity. Proceedings of the National Academy of Sciences of the United States of America. 107: 21806-11. PMID 21098665 DOI: 10.1073/pnas.1016399107  1
2010 Owen SF, Tsien RW. Inhibitory neurons hear themselves during development. Neuron. 66: 164-6. PMID 20434993 DOI: 10.1016/j.neuron.2010.04.021  1
2010 Cao YQ, Tsien RW. Different relationship of N- and P/Q-type Ca2+ channels to channel-interacting slots in controlling neurotransmission at cultured hippocampal synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4536-46. PMID 20357104 DOI: 10.1523/JNEUROSCI.5161-09.2010  1
2010 Bhat R, Axtell R, Mitra A, Miranda M, Lock C, Tsien RW, Steinman L. Inhibitory role for GABA in autoimmune inflammation. Proceedings of the National Academy of Sciences of the United States of America. 107: 2580-5. PMID 20133656 DOI: 10.1073/pnas.0915139107  1
2010 Tsien RW. Calcium Channel Subtypes Involved in Neurotransmitter Release Encyclopedia of Neuroscience. 535-542. DOI: 10.1016/B978-008045046-9.01645-4  1
2009 Espinosa JS, Wheeler DG, Tsien RW, Luo L. Uncoupling dendrite growth and patterning: single-cell knockout analysis of NMDA receptor 2B. Neuron. 62: 205-17. PMID 19409266 DOI: 10.1016/j.neuron.2009.03.006  1
2009 Zhang Q, Li Y, Tsien RW. The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles. Science (New York, N.Y.). 323: 1448-53. PMID 19213879 DOI: 10.1126/science.1167373  1
2009 Zhang Q, Li Y, Tsien RW. Response to comment on "the dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles" Science. 325: 1499-c. DOI: 10.1126/science.1176007  1
2008 Wheeler DG, Barrett CF, Groth RD, Safa P, Tsien RW. CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription coupling. The Journal of Cell Biology. 183: 849-63. PMID 19047462 DOI: 10.1083/jcb.200805048  1
2008 Groth RD, Tsien RW. A role for retinoic acid in homeostatic plasticity. Neuron. 60: 192-4. PMID 18957211 DOI: 10.1016/j.neuron.2008.10.003  1
2008 Watase K, Barrett CF, Miyazaki T, Ishiguro T, Ishikawa K, Hu Y, Unno T, Sun Y, Kasai S, Watanabe M, Gomez CM, Mizusawa H, Tsien RW, Zoghbi HY. Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels. Proceedings of the National Academy of Sciences of the United States of America. 105: 11987-92. PMID 18687887 DOI: 10.1073/pnas.0804350105  1
2008 Kim J, Tsien RW. Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation. Neuron. 58: 925-37. PMID 18579082 DOI: 10.1016/j.neuron.2008.05.009  1
2008 Liao YJ, Safa P, Chen YR, Sobel RA, Boyden ES, Tsien RW. Anti-Ca2+ channel antibody attenuates Ca2+ currents and mimics cerebellar ataxia in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 2705-10. PMID 18272482 DOI: 10.1073/pnas.0710771105  1
2008 Barrett CF, Tsien RW. The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels. Proceedings of the National Academy of Sciences of the United States of America. 105: 2157-62. PMID 18250309 DOI: 10.1073/pnas.0710501105  1
2007 Tsien RW. A remembrance of Professor TP FENG. Sheng Li Xue Bao : [Acta Physiologica Sinica]. 59: 713-5. PMID 23012741  1
2007 Zhang Q, Cao YQ, Tsien RW. Quantum dots provide an optical signal specific to full collapse fusion of synaptic vesicles. Proceedings of the National Academy of Sciences of the United States of America. 104: 17843-8. PMID 17968015 DOI: 10.1073/pnas.0706906104  1
2007 Lisman JE, Raghavachari S, Tsien RW. The sequence of events that underlie quantal transmission at central glutamatergic synapses. Nature Reviews. Neuroscience. 8: 597-609. PMID 17637801 DOI: 10.1038/nrn2191  1
2007 Shcherbakova OG, Hurt CM, Xiang Y, Dell'Acqua ML, Zhang Q, Tsien RW, Kobilka BK. Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes. The Journal of Cell Biology. 176: 521-33. PMID 17296797 DOI: 10.1083/jcb.200604167  1
2007 Thiagarajan TC, Lindskog M, Malgaroli A, Tsien RW. LTP and adaptation to inactivity: overlapping mechanisms and implications for metaplasticity. Neuropharmacology. 52: 156-75. PMID 16949624 DOI: 10.1016/j.neuropharm.2006.07.030  1
2007 Piedras-Rentería ES, Barrett CF, Cao YQ, Tsien RW. Voltage-gated calcium channels, calcium signaling, and channelopathies New Comprehensive Biochemistry. 41: 127-166. DOI: 10.1016/S0167-7306(06)41005-X  1
2006 Boyden ES, Katoh A, Pyle JL, Chatila TA, Tsien RW, Raymond JL. Selective engagement of plasticity mechanisms for motor memory storage. Neuron. 51: 823-34. PMID 16982426 DOI: 10.1016/j.neuron.2006.08.026  1
2006 Harata NC, Aravanis AM, Tsien RW. Kiss-and-run and full-collapse fusion as modes of exo-endocytosis in neurosecretion. Journal of Neurochemistry. 97: 1546-70. PMID 16805768 DOI: 10.1111/j.1471-4159.2006.03987.x  1
2006 Wheeler DG, Barrett CF, Tsien RW. L-type calcium channel ligands block nicotine-induced signaling to CREB by inhibiting nicotinic receptors. Neuropharmacology. 51: 27-36. PMID 16631827 DOI: 10.1016/j.neuropharm.2006.02.010  1
2006 Harata NC, Choi S, Pyle JL, Aravanis AM, Tsien RW. Frequency-dependent kinetics and prevalence of kiss-and-run and reuse at hippocampal synapses studied with novel quenching methods. Neuron. 49: 243-56. PMID 16423698 DOI: 10.1016/j.neuron.2005.12.018  1
2005 Hudmon A, Schulman H, Kim J, Maltez JM, Tsien RW, Pitt GS. CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. The Journal of Cell Biology. 171: 537-47. PMID 16275756 DOI: 10.1083/jcb.200505155  1
2005 Thiagarajan TC, Lindskog M, Tsien RW. Adaptation to synaptic inactivity in hippocampal neurons. Neuron. 47: 725-37. PMID 16129401 DOI: 10.1016/j.neuron.2005.06.037  1
2005 Barrett CF, Cao YQ, Tsien RW. Gating deficiency in a familial hemiplegic migraine type 1 mutant P/Q-type calcium channel. The Journal of Biological Chemistry. 280: 24064-71. PMID 15795222 DOI: 10.1074/jbc.M502223200  1
2005 Cao YQ, Tsien RW. Effects of familial hemiplegic migraine type 1 mutations on neuronal P/Q-type Ca2+ channel activity and inhibitory synaptic transmission. Proceedings of the National Academy of Sciences of the United States of America. 102: 2590-5. PMID 15699344 DOI: 10.1073/pnas.0409896102  1
2004 Cao YQ, Piedras-Rentería ES, Smith GB, Chen G, Harata NC, Tsien RW. Presynaptic Ca2+ channels compete for channel type-preferring slots in altered neurotransmission arising from Ca2+ channelopathy. Neuron. 43: 387-400. PMID 15294146 DOI: 10.1016/j.neuron.2004.07.014  1
2004 Piedras-Rentería ES, Pyle JL, Diehn M, Glickfeld LL, Harata NC, Cao Y, Kavalali ET, Brown PO, Tsien RW. Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway. Proceedings of the National Academy of Sciences of the United States of America. 101: 3609-14. PMID 14990796 DOI: 10.1073/pnas.0308188100  1
2004 Smith SM, Bergsman JB, Harata NC, Scheller RH, Tsien RW. Recordings from single neocortical nerve terminals reveal a nonselective cation channel activated by decreases in extracellular calcium. Neuron. 41: 243-56. PMID 14741105 DOI: 10.1016/S0896-6273(03)00837-7  1
2004 Chen G, Harata NC, Tsien RW. Paired-pulse depression of unitary quantal amplitude at single hippocampal synapses. Proceedings of the National Academy of Sciences of the United States of America. 101: 1063-8. PMID 14722357 DOI: 10.1073/pnas.0307149101  1
2004 Pagani R, Song M, McEnery M, Qin N, Tsien RW, Toro L, Stefani E, Uchitel OD. Differential expression of alpha 1 and beta subunits of voltage dependent Ca2+ channel at the neuromuscular junction of normal and P/Q Ca2+ channel knockout mouse. Neuroscience. 123: 75-85. PMID 14667443 DOI: 10.1016/j.neuroscience.2003.09.019  1
2003 Aravanis AM, Pyle JL, Harata NC, Tsien RW. Imaging single synaptic vesicles undergoing repeated fusion events: kissing, running, and kissing again. Neuropharmacology. 45: 797-813. PMID 14529718 DOI: 10.1016/S0028-3908(03)00310-1  1
2003 Deisseroth K, Mermelstein PG, Xia H, Tsien RW. Signaling from synapse to nucleus: the logic behind the mechanisms. Current Opinion in Neurobiology. 13: 354-65. PMID 12850221 DOI: 10.1016/S0959-4388(03)00076-X  1
2003 Aravanis AM, Pyle JL, Tsien RW. Single synaptic vesicles fusing transiently and successively without loss of identity. Nature. 423: 643-7. PMID 12789339 DOI: 10.1038/nature01686  1
2003 Choi S, Klingauf J, Tsien RW. Fusion pore modulation as a presynaptic mechanism contributing to expression of long-term potentiation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 358: 695-705. PMID 12740115 DOI: 10.1098/rstb.2002.1249  1
2003 Urbano FJ, Piedras-Rentería ES, Jun K, Shin HS, Uchitel OD, Tsien RW. Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels. Proceedings of the National Academy of Sciences of the United States of America. 100: 3491-6. PMID 12624181 DOI: 10.1073/pnas.0437991100  1
2002 Thiagarajan TC, Piedras-Renteria ES, Tsien RW. alpha- and betaCaMKII. Inverse regulation by neuronal activity and opposing effects on synaptic strength. Neuron. 36: 1103-14. PMID 12495625 DOI: 10.1016/S0896-6273(02)01049-8  1
2002 Cataldi M, Perez-Reyes E, Tsien RW. Differences in apparent pore sizes of low and high voltage-activated Ca2+ channels. The Journal of Biological Chemistry. 277: 45969-76. PMID 12198115 DOI: 10.1074/jbc.M203922200  1
2002 Deisseroth K, Tsien RW. Dynamic multiphosphorylation passwords for activity-dependent gene expression. Neuron. 34: 179-82. PMID 11970860 DOI: 10.1016/S0896-6273(02)00664-5  1
2001 Mermelstein PG, Deisseroth K, Dasgupta N, Isaksen AL, Tsien RW. Calmodulin priming: nuclear translocation of a calmodulin complex and the memory of prior neuronal activity. Proceedings of the National Academy of Sciences of the United States of America. 98: 15342-7. PMID 11742070 DOI: 10.1073/pnas.211563998  1
2001 Piedras-Renteria ES, Watase K, Harata N, Zhuchenko O, Zoghbi HY, Lee CC, Tsien RW. Increased expression of alpha 1A Ca2+ channel currents arising from expanded trinucleotide repeats in spinocerebellar ataxia type 6. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9185-93. PMID 11717352  1
2001 Harata N, Ryan TA, Smith SJ, Buchanan J, Tsien RW. Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversion. Proceedings of the National Academy of Sciences of the United States of America. 98: 12748-53. PMID 11675506 DOI: 10.1073/pnas.171442798  1
2001 Harata N, Pyle JL, Aravanis AM, Mozhayeva M, Kavalali ET, Tsien RW. Limited numbers of recycling vesicles in small CNS nerve terminals: implications for neural signaling and vesicular cycling. Trends in Neurosciences. 24: 637-43. PMID 11672807 DOI: 10.1016/S0166-2236(00)02030-0  1
2001 Pitt GS, Zühlke RD, Hudmon A, Schulman H, Reuter H, Tsien RW. Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels. The Journal of Biological Chemistry. 276: 30794-802. PMID 11408490 DOI: 10.1074/jbc.M104959200  1
2001 Wu GY, Deisseroth K, Tsien RW. Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. Proceedings of the National Academy of Sciences of the United States of America. 98: 2808-13. PMID 11226322 DOI: 10.1073/pnas.051634198  1
2001 Wu GY, Deisseroth K, Tsien RW. Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology. Nature Neuroscience. 4: 151-8. PMID 11175875 DOI: 10.1038/83976  1
2000 Bezprozvanny I, Zhong P, Scheller RH, Tsien RW. Molecular determinants of the functional interaction between syntaxin and N-type Ca2+ channel gating. Proceedings of the National Academy of Sciences of the United States of America. 97: 13943-8. PMID 11087812 DOI: 10.1073/pnas.220389697  1
2000 Pyle JL, Kavalali ET, Piedras-Rentería ES, Tsien RW. Rapid reuse of readily releasable pool vesicles at hippocampal synapses. Neuron. 28: 221-31. PMID 11086996  1
2000 Bergsman JB, Tsien RW. Syntaxin modulation of calcium channels in cortical synaptosomes as revealed by botulinum toxin C1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4368-78. PMID 10844005  1
2000 Degtiar VE, Scheller RH, Tsien RW. Syntaxin modulation of slow inactivation of N-type calcium channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4355-67. PMID 10844004  1
2000 Zühlke RD, Pitt GS, Tsien RW, Reuter H. Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit. The Journal of Biological Chemistry. 275: 21121-9. PMID 10779517 DOI: 10.1074/jbc.M002986200  1
2000 Ertel EA, Campbell KP, Harpold MM, Hofmann F, Mori Y, Perez-Reyes E, Schwartz A, Snutch TP, Tanabe T, Birnbaumer L, Tsien RW, Catterall WA. Nomenclature of voltage-gated calcium channels. Neuron. 25: 533-5. PMID 10774722  0.68
2000 Choi S, Klingauf J, Tsien RW. Postfusional regulation of cleft glutamate concentration during LTP at 'silent synapses'. Nature Neuroscience. 3: 330-6. PMID 10725921 DOI: 10.1038/73895  1
2000 Mermelstein PG, Bito H, Deisseroth K, Tsien RW. Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 266-73. PMID 10627604  1
1999 Pyle JL, Kavalali ET, Choi S, Tsien RW. Visualization of synaptic activity in hippocampal slices with FM1-43 enabled by fluorescence quenching. Neuron. 24: 803-8. PMID 10624944  1
1999 Jun K, Piedras-Rentería ES, Smith SM, Wheeler DB, Lee SB, Lee TG, Chin H, Adams ME, Scheller RH, Tsien RW, Shin HS. Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit. Proceedings of the National Academy of Sciences of the United States of America. 96: 15245-50. PMID 10611370 DOI: 10.1073/pnas.96.26.15245  1
1999 Graef IA, Mermelstein PG, Stankunas K, Neilson JR, Deisseroth K, Tsien RW, Crabtree GR. L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature. 401: 703-8. PMID 10537109 DOI: 10.1038/44378  1
1999 Kavalali ET, Klingauf J, Tsien RW. Activity-dependent regulation of synaptic clustering in a hippocampal culture system. Proceedings of the National Academy of Sciences of the United States of America. 96: 12893-900. PMID 10536019 DOI: 10.1073/pnas.96.22.12893  1
1999 Smith SM, Piedras-Renterà ES, Namkung Y, Shin HS, Tsien RW. Neuronal voltage-activated calcium channels: on the roles of the alpha 1E and beta 3 subunits. Annals of the New York Academy of Sciences. 868: 175-98. PMID 10414294 DOI: 10.1111/j.1749-6632.1999.tb11286.x  1
1999 Zühlke RD, Pitt GS, Deisseroth K, Tsien RW, Reuter H. Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature. 399: 159-62. PMID 10335846 DOI: 10.1038/20200  1
1999 Kavalali ET, Klingauf J, Tsien RW. Properties of fast endocytosis at hippocampal synapses. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 354: 337-46. PMID 10212482 DOI: 10.1098/rstb.1999.0385  1
1999 Liu G, Choi S, Tsien RW. Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices. Neuron. 22: 395-409. PMID 10069344  1
1998 Newcomb R, Szoke B, Palma A, Wang G, Chen Xh, Hopkins W, Cong R, Miller J, Urge L, Tarczy-Hornoch K, Loo JA, Dooley DJ, Nadasdi L, Tsien RW, Lemos J, et al. Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochemistry. 37: 15353-62. PMID 9799496 DOI: 10.1021/bi981255g  1
1998 Namkung Y, Smith SM, Lee SB, Skrypnyk NV, Kim HL, Chin H, Scheller RH, Tsien RW, Shin HS. Targeted disruption of the Ca2+ channel beta3 subunit reduces N- and L-type Ca2+ channel activity and alters the voltage-dependent activation of P/Q-type Ca2+ channels in neurons. Proceedings of the National Academy of Sciences of the United States of America. 95: 12010-5. PMID 9751781 DOI: 10.1073/pnas.95.20.12010  1
1998 Klingauf J, Kavalali ET, Tsien RW. Kinetics and regulation of fast endocytosis at hippocampal synapses. Nature. 394: 581-5. PMID 9707119 DOI: 10.1038/29079  1
1998 Piedras-Rentería ES, Tsien RW. Antisense oligonucleotides against alpha1E reduce R-type calcium currents in cerebellar granule cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 7760-5. PMID 9636224 DOI: 10.1073/pnas.95.13.7760  1
1998 Deisseroth K, Heist EK, Tsien RW. Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature. 392: 198-202. PMID 9515967 DOI: 10.1038/32448  1
1998 Tsien RW. Molecular physiology. Key clockwork component cloned. Nature. 391: 839, 841. PMID 9495332 DOI: 10.1038/35981  1
1997 Chen XH, Tsien RW. Aspartate substitutions establish the concerted action of P-region glutamates in repeats I and III in forming the protonation site of L-type Ca2+ channels. The Journal of Biological Chemistry. 272: 30002-8. PMID 9374474 DOI: 10.1074/jbc.272.48.30002  1
1997 Randall AD, Tsien RW. Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels. Neuropharmacology. 36: 879-93. PMID 9257934 DOI: 10.1016/S0028-3908(97)00086-5  1
1997 Bito H, Deisseroth K, Tsien RW. Ca2+-dependent regulation in neuronal gene expression. Current Opinion in Neurobiology. 7: 419-29. PMID 9232807 DOI: 10.1016/S0959-4388(97)80072-4  1
1997 Kavalali ET, Zhuo M, Bito H, Tsien RW. Dendritic Ca2+ channels characterized by recordings from isolated hippocampal dendritic segments. Neuron. 18: 651-63. PMID 9136773  1
1997 Stocker JW, Nadasdi L, Aldrich RW, Tsien RW. Preferential interaction of omega-conotoxins with inactivated N-type Ca2+ channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 3002-13. PMID 9096136  1
1996 Bito H, Deisseroth K, Tsien RW. CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression. Cell. 87: 1203-14. PMID 8980227 DOI: 10.1016/S0092-8674(00)81816-4  1
1996 Zhang JF, Ellinor PT, Aldrich RW, Tsien RW. Multiple structural elements in voltage-dependent Ca2+ channels support their inhibition by G proteins. Neuron. 17: 991-1003. PMID 8938130 DOI: 10.1016/S0896-6273(00)80229-9  1
1996 Chen XH, Bezprozvanny I, Tsien RW. Molecular basis of proton block of L-type Ca2+ channels. The Journal of General Physiology. 108: 363-74. PMID 8923262 DOI: 10.1085/jgp.108.5.363  1
1996 Wheeler DB, Randall A, Tsien RW. Changes in action potential duration alter reliance of excitatory synaptic transmission on multiple types of Ca2+ channels in rat hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 2226-37. PMID 8601803  1
1996 Deisseroth K, Bito H, Tsien RW. Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron. 16: 89-101. PMID 8562094 DOI: 10.1016/S0896-6273(00)80026-4  1
1996 Bito H, Deisseroth K, Tsien RW. Signaling from synapse to nucleus: Ca2+-dependent control at h1ppocampal synapses of nuclear creb phosphorylation Faseb Journal. 10: A1421.  1
1995 Deisseroth K, Bito H, Schulman H, Tsien RW. Synaptic plasticity: A molecular mechanism for metaplasticity. Current Biology : Cb. 5: 1334-8. PMID 8749377 DOI: 10.1016/S0960-9822(95)00262-4  1
1995 Liu G, Tsien RW. Synaptic transmission at single visualized hippocampal boutons. Neuropharmacology. 34: 1407-21. PMID 8606790 DOI: 10.1016/0028-3908(95)00143-T  1
1995 Bezprozvanny I, Scheller RH, Tsien RW. Functional impact of syntaxin on gating of N-type and Q-type calcium channels. Nature. 378: 623-6. PMID 8524397 DOI: 10.1038/378623a0  1
1995 Malgaroli A, Ting AE, Wendland B, Bergamaschi A, Villa A, Tsien RW, Scheller RH. Presynaptic component of long-term potentiation visualized at individual hippocampal synapses. Science (New York, N.Y.). 268: 1624-8. PMID 7777862  1
1995 Liu G, Tsien RW. Properties of synaptic transmission at single hippocampal synaptic boutons. Nature. 375: 404-8. PMID 7760934 DOI: 10.1038/375404a0  1
1995 Randall A, Tsien RW. Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 2995-3012. PMID 7722641  1
1995 Ellinor PT, Yang J, Sather WA, Zhang JF, Tsien RW. Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions. Neuron. 15: 1121-32. PMID 7576655 DOI: 10.1016/0896-6273(95)90100-0  1
1995 Wheeler DB, Randall A, Sather WA, Tsien RW. Neuronal calcium channels encoded by the alpha 1A subunit and their contribution to excitatory synaptic transmission in the CNS. Progress in Brain Research. 105: 65-78. PMID 7568898  1
1995 Bezprozvanny I, Tsien RW. Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967). Molecular Pharmacology. 48: 540-9. PMID 7565636  1
1995 Tsien RW, Lipscombe D, Madison D, Bley K, Fox A. Reflections on Ca(2+)-channel diversity, 1988-1994. Trends in Neurosciences. 18: 52-4. PMID 7537405 DOI: 10.1016/0166-2236(95)80015-T  1
1994 Wheeler DB, Tsien RW, Randall A. Response. Science (New York, N.Y.). 266: 830-1. PMID 17730402 DOI: 10.1126/science.266.5186.830  0.96
1994 Friel DD, Tsien RW. An FCCP-sensitive Ca2+ store in bullfrog sympathetic neurons and its participation in stimulus-evoked changes in [Ca2+]i. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 4007-24. PMID 8027759  1
1994 Dunlap K, Luebke JI, Turner TJ. Identification of calcium channels that control neurosecretion. Science (New York, N.Y.). 266: 828-31. PMID 7973643  1
1994 Ellinor PT, Zhang JF, Horne WA, Tsien RW. Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin. Nature. 372: 272-5. PMID 7969473 DOI: 10.1038/372272a0  1
1994 Zhang JF, Ellinor PT, Aldrich RW, Tsien RW. Molecular determinants of voltage-dependent inactivation in calcium channels. Nature. 372: 97-100. PMID 7969428 DOI: 10.1038/372097a0  1
1994 Birnbaumer L, Campbell KP, Catterall WA, Harpold MM, Hofmann F, Horne WA, Mori Y, Schwartz A, Snutch TP, Tanabe T. The naming of voltage-gated calcium channels. Neuron. 13: 505-6. PMID 7917287  0.68
1994 Wheeler DB, Sather WA, Randall A, Tsien RW. Distinctive properties of a neuronal calcium channel and its contribution to excitatory synaptic transmission in the central nervous system. Advances in Second Messenger and Phosphoprotein Research. 29: 155-71. PMID 7848709  1
1994 Sather WA, Tanabe T, Zhang JF, Tsien RW. Biophysical and pharmacological characterization of a class A calcium channel. Annals of the New York Academy of Sciences. 747: 294-301. PMID 7847678  1
1994 Wheeler DB, Randall A, Tsien RW. Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission. Science (New York, N.Y.). 264: 107-11. PMID 7832825  1
1994 Chiang LW, Schweizer FE, Tsien RW, Schulman H. Nitric oxide synthase expression in single hippocampal neurons. Brain Research. Molecular Brain Research. 27: 183-8. PMID 7533235 DOI: 10.1016/0169-328X(94)90202-X  1
1994 Sather WA, Yang J, Tsien RW. Structural basis of ion channel permeation and selectivity. Current Opinion in Neurobiology. 4: 313-23. PMID 7522675 DOI: 10.1016/0959-4388(94)90091-4  1
1994 Wendland B, Schweizer FE, Ryan TA, Nakane M, Murad F, Scheller RH, Tsien RW. Existence of nitric oxide synthase in rat hippocampal pyramidal cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 2151-5. PMID 7510887  1
1993 Ryan TA, Reuter H, Wendland B, Schweizer FE, Tsien RW, Smith SJ. The kinetics of synaptic vesicle recycling measured at single presynaptic boutons. Neuron. 11: 713-24. PMID 8398156 DOI: 10.1016/0896-6273(93)90081-2  1
1993 Sather WA, Tanabe T, Zhang JF, Mori Y, Adams ME, Tsien RW. Distinctive biophysical and pharmacological properties of class A (BI) calcium channel alpha 1 subunits. Neuron. 11: 291-303. PMID 8394721 DOI: 10.1016/0896-6273(93)90185-T  1
1993 Ellinor PT, Zhang JF, Randall AD, Zhou M, Schwarz TL, Tsien RW, Horne WA. Functional expression of a rapidly inactivating neuronal calcium channel. Nature. 363: 455-8. PMID 8389006 DOI: 10.1038/363455a0  1
1993 Yang J, Tsien RW. Enhancement of N- and L-type calcium channel currents by protein kinase C in frog sympathetic neurons. Neuron. 10: 127-36. PMID 8382496 DOI: 10.1016/0896-6273(93)90305-B  1
1993 Delcour AH, Lipscombe D, Tsien RW. Multiple modes of N-type calcium channel activity distinguished by differences in gating kinetics. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 181-94. PMID 8380849  1
1993 Yang J, Ellinor PT, Sather WA, Zhang JF, Tsien RW. Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels. Nature. 366: 158-61. PMID 8232554 DOI: 10.1038/366158a0  1
1993 Zhang JF, Randall AD, Ellinor PT, Horne WA, Sather WA, Tanabe T, Schwarz TL, Tsien RW. Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons. Neuropharmacology. 32: 1075-88. PMID 8107963 DOI: 10.1016/0028-3908(93)90003-L  1
1993 Delcour AH, Tsien RW. Altered prevalence of gating modes in neurotransmitter inhibition of N-type calcium channels. Science (New York, N.Y.). 259: 980-4. PMID 8094902  1
1993 Horne WA, Ellinor PT, Inman I, Zhou M, Tsien RW, Schwarz TL. Molecular diversity of Ca2+ channel alpha 1 subunits from the marine ray Discopyge ommata. Proceedings of the National Academy of Sciences of the United States of America. 90: 3787-91. PMID 7683405  1
1993 Randall AD, Deisseroth K, Tsien RW. Excitatory and inhibitory synaptic connectivity between cultured rat cerebellar granule cells Journal of Physiology. 473: 153P.  1
1993 Randall AD, Tsien RW. Kinetic analysis of EPSCs and IPSCs recorded from cultured rat cerebellar granule cells Journal of Physiology. 473: 154P.  1
1992 Friel DD, Tsien RW. Phase-dependent contributions from Ca2+ entry and Ca2+ release to caffeine-induced [Ca2+]i oscillations in bullfrog sympathetic neurons. Neuron. 8: 1109-25. PMID 1610566 DOI: 10.1016/0896-6273(92)90132-W  1
1992 Friel DD, Tsien RW. A caffeine- and ryanodine-sensitive Ca2+ store in bullfrog sympathetic neurones modulates effects of Ca2+ entry on [Ca2+]i. The Journal of Physiology. 450: 217-46. PMID 1432708  1
1992 Malgaroli A, Tsien RW. Glutamate-induced long-term potentiation of the frequency of miniature synaptic currents in cultured hippocampal neurons. Nature. 357: 134-9. PMID 1349728 DOI: 10.1038/357134a0  1
1992 Malgaroli A, Malinow R, Schulman H, Tsien RW. Persistent signalling and changes in presynaptic function in long-term potentiation. Ciba Foundation Symposium. 164: 176-91; discussion 1. PMID 1327679  1
1992 Malgaroli A, Tsien RW. Presynaptic site of expression for long-term potentiation in cultured hippocampal neurons Pharmacological Research. 26: 214.  1
1991 Malinow R, Tsien RW. Long-term potentiation: postsynaptic activation of Ca(2+)-dependent protein kinases with subsequent presynaptic enhancement. Progress in Brain Research. 89: 271-89. PMID 1796143  1
1991 Tsien RW, Malinow R. Changes in presynaptic function during long-term potentiation. Annals of the New York Academy of Sciences. 635: 208-20. PMID 1741585  1
1991 Cline HT, Tsien RW. Glutamate-induced increases in intracellular Ca2+ in cultured frog tectal cells mediated by direct activation of NMDA receptor channels. Neuron. 6: 259-67. PMID 1704244 DOI: 10.1016/0896-6273(91)90361-3  1
1991 Tsien RW, Ellinor PT, Horne WA. Molecular diversity of voltage-dependent Ca2+ channels. Trends in Pharmacological Sciences. 12: 349-54. PMID 1659003 DOI: 10.1016/0165-6147(91)90595-J  1
1991 Degtiar' VE, Kondrashova LN. [Effect of ammonium perchlorate on calcium currents in neurons and leukocyte mobility]. Neir̆Ofiziologiia = Neurophysiology. 23: 242-4. PMID 1652106  0.68
1991 Horne WA, Hawrot E, Tsien RW. omega-Conotoxin GVIA receptors of Discopyge electric organ. Characterization of omega-conotoxin binding to the nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 266: 13719-25. PMID 1649828  1
1991 Malinow R, Tsien RW. A reply - Is maintenance of LTP presynaptic? [11] Nature. 350: 282.  1
1990 Tsien RW, Schulman H, Malinow R. Peptide inhibitors of PKC and CaMK block induction but not expression of long-term potentiation. Advances in Second Messenger and Phosphoprotein Research. 24: 101-7. PMID 2169790  1
1990 Malinow R, Tsien RW. Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices. Nature. 346: 177-80. PMID 2164158 DOI: 10.1038/346177a0  1
1990 Tsien RW, Malinow R. Long-term potentiation: presynaptic enhancement following postsynaptic activation of Ca(++)-dependent protein kinases. Cold Spring Harbor Symposia On Quantitative Biology. 55: 147-59. PMID 1966762  1
1990 Malinow R, Tsien RW. Identifying and localizing protein kinases necessary for LTP. Advances in Experimental Medicine and Biology. 268: 301-5. PMID 1963742  1
1990 Bley KR, Tsien RW. Inhibition of Ca2+ and K+ channels in sympathetic neurons by neuropeptides and other ganglionic transmitters. Neuron. 4: 379-91. PMID 1690565 DOI: 10.1016/0896-6273(90)90050-P  1
1989 Lipscombe D, Kongsamut S, Tsien RW. Alpha-adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium-channel gating. Nature. 340: 639-42. PMID 2570354 DOI: 10.1038/340639a0  1
1989 Kongsamut S, Lipscombe D, Tsien RW. The N-type Ca channel in frog sympathetic neurons and its role in alpha-adrenergic modulation of transmitter release. Annals of the New York Academy of Sciences. 560: 312-33. PMID 2568108  1
1989 Malinow R, Schulman H, Tsien RW. Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP. Science (New York, N.Y.). 245: 862-6. PMID 2549638  1
1989 Skryma RN, Kalashnikova LE, Degtiar' VE, Prevarskaia NB, Burdyga FV. [Action of the leukotriene LTC4 on the calcium channels of the somatic membrane of the nerve cell and tone of smooth muscle organs]. Neir̆Ofiziologiia = Neurophysiology. 21: 262-4. PMID 2547168  0.32
1989 Rosenberg RL, Isaacson JS, Tsien RW. Solubilization, partial purification, and properties of omega-conotoxin receptors associated with voltage-dependent calcium channels from rat brain synaptosomes. Annals of the New York Academy of Sciences. 560: 39-52. PMID 2545145  1
1989 Friel DD, Tsien RW. Voltage-gated calcium channels: direct observation of the anomalous mole fraction effect at the single-channel level. Proceedings of the National Academy of Sciences of the United States of America. 86: 5207-11. PMID 2544893  1
1989 Skryma RN, ZaÄ­tsev LM, Degtiar' VE, Kalashnikova LE, Kvita GI. [Features of the effect of leukotriene LTC4 and the blocker of its biosynthesis BW755C on the contractile capability of smooth muscles and the functioning of potential-dependent calcium channels of the nerve cell]. Neir̆Ofiziologiia = Neurophysiology. 21: 24-31. PMID 2542815  0.56
1988 Miller RJ, Ewald DA, Fox AP, Hirning LD, McCleskey EW, Perney TM, Sturek M, Thayer SA, Tsien RW, Walker MW. The effect of calcium channel antagonists on peripheral neurones. Annals of the New York Academy of Sciences. 522: 269-77. PMID 3288051  1
1988 Benham CD, Tsien RW. Noradrenaline modulation of calcium channels in single smooth muscle cells from rabbit ear artery. The Journal of Physiology. 404: 767-84. PMID 2855354 DOI: 10.1113/jphysiol.1988.sp017318  1
1988 Malinow R, Madison DV, Tsien RW. Persistent protein kinase activity underlying long-term potentiation. Nature. 335: 820-4. PMID 2847049 DOI: 10.1038/335820a0  1
1988 Rosenberg RL, Hess P, Tsien RW. Cardiac calcium channels in planar lipid bilayers. L-type channels and calcium-permeable channels open at negative membrane potentials. The Journal of General Physiology. 92: 27-54. PMID 2844956  1
1988 Tsien RW, Lipscombe D, Madison DV, Bley KR, Fox AP. Multiple types of neuronal calcium channels and their selective modulation. Trends in Neurosciences. 11: 431-8. PMID 2469160 DOI: 10.1016/0166-2236(88)90194-4  1
1988 Hirning LD, Fox AP, McCleskey EW, Olivera BM, Thayer SA, Miller RJ, Tsien RW. Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons. Science (New York, N.Y.). 239: 57-61. PMID 2447647  1
1988 Rosenberg RL, McCleskey EW, Hess P, Tsien RW. Chapter 19 Cardiac Calcium Channels: Pore Size and Symmetry of Energy Profile Current Topics in Membranes and Transport. 33: 393-413. DOI: 10.1016/S0070-2161(08)60909-0  1
1987 Benham CD, Tsien RW. Calcium-permeable channels in vascular smooth muscle: voltage-activated, receptor-operated, and leak channels. Society of General Physiologists Series. 42: 45-64. PMID 2850612  1
1987 Fox AP, Nowycky MC, Tsien RW. Single-channel recordings of three types of calcium channels in chick sensory neurones. The Journal of Physiology. 394: 173-200. PMID 2451017  1
1987 Fox AP, Nowycky MC, Tsien RW. Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones. The Journal of Physiology. 394: 149-72. PMID 2451016  1
1987 Tsien RW, Nilius B. Cardiac calcium currents at the level of single channels. Experientia. 43: 1169-72. PMID 2446910 DOI: 10.1007/BF01945517  1
1987 Benham CD, Hess P, Tsien RW. Two types of calcium channels in single smooth muscle cells from rabbit ear artery studied with whole-cell and single-channel recordings. Circulation Research. 61: I10-6. PMID 2443270  1
1987 Lieberman M, Hauschka SD, Hall ZW, Eisenberg BR, Horn R, Walsh JV, Tsien RW, Jones AW, Walker JL, Poenie M. Isolated muscle cells as a physiological model. The American Journal of Physiology. 253: C349-63. PMID 2443014  1
1987 Benham CD, Tsien RW. A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle. Nature. 328: 275-8. PMID 2439921 DOI: 10.1038/328275a0  1
1987 Tsien RW, Hess P, McCleskey EW, Rosenberg RL. Calcium channels: mechanisms of selectivity, permeation, and block. Annual Review of Biophysics and Biophysical Chemistry. 16: 265-90. PMID 2439098 DOI: 10.1146/annurev.bb.16.060187.001405  1
1987 McCleskey EW, Fox AP, Feldman DH, Cruz LJ, Olivera BM, Tsien RW, Yoshikami D. Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle. Proceedings of the National Academy of Sciences of the United States of America. 84: 4327-31. PMID 2438698 DOI: 10.1073/pnas.84.12.4327  1
1987 Tsien RW, Fox AP, Hess P, McCleskey EW, Nilius B, Nowycky MC, Rosenberg RL. Multiple types of calcium channel in excitable cells. Society of General Physiologists Series. 41: 167-87. PMID 2436308  1
1987 Strong JA, Fox AP, Tsien RW, Kaczmarek LK. Stimulation of protein kinase C recruits covert calcium channels in Aplysia bag cell neurons. Nature. 325: 714-7. PMID 2434853 DOI: 10.1038/325714a0  1
1986 Hess P, Lansman JB, Nilius B, Tsien RW. Calcium channel types in cardiac myocytes: modulation by dihydropyridines and beta-adrenergic stimulation. Journal of Cardiovascular Pharmacology. 8: S11-21. PMID 2433538  1
1986 Lansman JB, Hess P, Tsien RW. Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore. The Journal of General Physiology. 88: 321-47. PMID 2428920  1
1986 Hess P, Lansman JB, Tsien RW. Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells. The Journal of General Physiology. 88: 293-319. PMID 2428919  1
1986 McCleskey EW, Fox AP, Feldman D, Tsien RW. Different types of calcium channels. The Journal of Experimental Biology. 124: 177-90. PMID 2428899  1
1986 Tsien RW, Bean BP, Hess P, Lansman JB, Nilius B, Nowycky MC. Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists. Journal of Molecular and Cellular Cardiology. 18: 691-710. PMID 2427730 DOI: 10.1016/S0022-2828(86)80941-5  1
1986 Nilius B, Hess P, Lansman JB, Tsien RW. A novel type of cardiac calcium channel in ventricular cells. Biomedica Biochimica Acta. 45: S167-70. PMID 2421713  1
1986 Rosenberg RL, Hess P, Reeves JP, Smilowitz H, Tsien RW. Calcium channels in planar lipid bilayers: insights into mechanisms of ion permeation and gating. Science (New York, N.Y.). 231: 1564-6. PMID 2420007  1
1985 Nowycky MC, Fox AP, Tsien RW. Long-opening mode of gating of neuronal calcium channels and its promotion by the dihydropyridine calcium agonist Bay K 8644. Proceedings of the National Academy of Sciences of the United States of America. 82: 2178-82. PMID 2580308  1
1985 Lee KS, Marban E, Tsien RW. Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium. The Journal of Physiology. 364: 395-411. PMID 2411919 DOI: 10.1113/jphysiol.1985.sp015752  1
1985 Nilius B, Hess P, Lansman JB, Tsien RW. A novel type of cardiac calcium channel in ventricular cells. Nature. 316: 443-6. PMID 2410797 DOI: 10.1038/316443a0  1
1985 Nowycky MC, Fox AP, Tsien RW. Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature. 316: 440-3. PMID 2410796 DOI: 10.1038/316440a0  1
1984 Cohen CJ, Bean BP, Tsien RW. Maximal upstroke velocity as an index of available sodium conductance. Comparison of maximal upstroke velocity and voltage clamp measurements of sodium current in rabbit Purkinje fibers. Circulation Research. 54: 636-51. PMID 6329543  1
1984 Hess P, Tsien RW. Mechanism of ion permeation through calcium channels. Nature. 309: 453-6. PMID 6328315 DOI: 10.1038/309453a0  1
1984 Bean BP, Nowycky MC, Tsien RW. Beta-adrenergic modulation of calcium channels in frog ventricular heart cells. Nature. 307: 371-5. PMID 6320002 DOI: 10.1038/307371a0  1
1984 Hess P, Lansman JB, Tsien RW. Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature. 311: 538-44. PMID 6207437 DOI: 10.1038/311538a0  1
1984 Lee KS, Tsien RW. High selectivity of calcium channels in single dialysed heart cells of the guinea-pig. The Journal of Physiology. 354: 253-72. PMID 6090649 DOI: 10.1113/jphysiol.1984.sp015374  1
1983 Tsien RW, Bean BP, Hess P, Nowycky M. Calcium channels: mechanisms of beta-adrenergic modulation and ion permeation. Cold Spring Harbor Symposia On Quantitative Biology. 48: 201-12. PMID 6327154  1
1983 Bean BP, Cohen CJ, Tsien RW. Lidocaine block of cardiac sodium channels. The Journal of General Physiology. 81: 613-42. PMID 6306139  1
1983 Tsien RW. Calcium channels in excitable cell membranes. Annual Review of Physiology. 45: 341-58. PMID 6303205 DOI: 10.1146/annurev.ph.45.030183.002013  1
1983 Lee KS, Tsien RW. Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature. 302: 790-4. PMID 6302512 DOI: 10.1038/302790a0  1
1983 Siegelbaum SA, Tsien RW. Modulation of gated ion channels as a mode of transmitter action Trends in Neurosciences. 6: 307-313. DOI: 10.1016/0166-2236(83)90145-5  1
1982 Kass RS, Tsien RW. Fluctuations in membrane current driven by intracellular calcium in cardiac Purkinje fibers. Biophysical Journal. 38: 259-69. PMID 6809065 DOI: 10.1016/S0006-3495(82)84557-8  1
1982 Marban E, Tsien RW. Enhancement of calcium current during digitalis inotropy in mammalian heart: positive feed-back regulation by intracellular calcium? The Journal of Physiology. 329: 589-614. PMID 6292410 DOI: 10.1113/jphysiol.1982.sp014321  1
1982 Marban E, Tsien RW. Effects of nystatin-mediated intracellular ion substitution on membrane currents in calf purkinje fibres. The Journal of Physiology. 329: 569-87. PMID 6292409 DOI: 10.1113/jphysiol.1982.sp014320  1
1982 Reuter H, Stevens CF, Tsien RW, Yellen G. Properties of single calcium channels in cardiac cell culture. Nature. 297: 501-4. PMID 6283360 DOI: 10.1038/297501a0  1
1982 Lee KS, Tsien RW. Reversal of current through calcium channels in dialysed single heart cells. Nature. 297: 498-501. PMID 6283359  0.96
1982 Lee KS, Lee EW, Tsien RW. Comparison between Ca2+ channel block by Cd2+ and D600 in single mammalian heart cells Biophysical Journal. 37.  1
1981 Cohen CJ, Bean BP, Colatsky TJ, Tsien RW. Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating. The Journal of General Physiology. 78: 383-411. PMID 6270235  1
1981 Marban E, Tsien RW. Is the slow inward calcium current of heart muscle inactivated by calcium? Biophysical Journal. 33.  1
1981 Lee KS, Lee EW, Tsien RW. Slow inward current carried by Ca2+ or Ba2+ in single isolated heart cells Biophysical Journal. 33.  1
1981 Bean BP, Cohen CJ, Tsien RW. Lidocaine binding to resting and inactivated cardiac sodium channels Biophysical Journal. 33: T-PM-D6.  1
1980 Siegelbaum SA, Tsien RW. Calcium-activated transient outward current in calf cardiac Purkinje fibres. The Journal of Physiology. 299: 485-506. PMID 6770079 DOI: 10.1113/jphysiol.1980.sp013138  1
1980 Bean BP, Cohen CJ, Colatsky TJ, Tsien RW. Concentration-dependence of tetrodotoxin action on sodium currents and maximal upstroke velocity in rabbit cardiac Purkinje fibres Journal of Physiology. 23P.  1
1979 Cohen CJ, Colatsky TJ, Tsien RW. Tetrodotoxin block of cardiac sodium channels during repetitive or steady depolarizations in the rabbit [proceedings]. The Journal of Physiology. 296: 70P-71P. PMID 529142  1
1979 Tsien RW, Kass RS, Weingart R. Cellular and subcellular mechanisms of cardiac pacemaker oscillations. The Journal of Experimental Biology. 81: 205-15. PMID 512578  1
1979 Marban E, Tsien RW. Ouabain increases the slow inward calcium current in ventricular muscle of the ferret [proceedings]. The Journal of Physiology. 292: 72P-73P. PMID 490409  1
1979 Colatsky TJ, Tsien RW. Electrical properties associated with wide intercellular clefts in rabbit Purkinje fibres. The Journal of Physiology. 290: 227-52. PMID 469754 DOI: 10.1113/jphysiol.1979.sp012769  1
1979 Kass RS, Siegelbaum SA, Tsien RW. Three-micro-electrode voltage clamp experiments in calf cardiac Purkinje fibres: is slow inward current adequately measured? The Journal of Physiology. 290: 201-25. PMID 469751 DOI: 10.1113/jphysiol.1979.sp012768  1
1979 Siegelbaum SA, Tsien RW. Calcium-activated transient outward current in cardiac Purkinje fibres [proceedings]. The Journal of Physiology. 287: 36P-37P. PMID 430419  1
1979 Colatsky JJ, Tsien RW. Sodium channels in rabbit cardiac Purkinje fibres. Nature. 278: 265-8. PMID 423977 DOI: 10.1038/278265a0  1
1979 Marban E, Tsien RW. Membrane current changes associated with digitalis inotropy in mammalian heart muscle Naunyn-Schmiedeberg's Archives of Pharmacology. 308.  1
1978 Kass RS, Tsien RW, Weingart R. Ionic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibres. The Journal of Physiology. 281: 209-26. PMID 702372 DOI: 10.1113/jphysiol.1978.sp012417  1
1978 Kass RS, Lederer WJ, Tsien RW, Weingart R. Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres. The Journal of Physiology. 281: 187-208. PMID 702368 DOI: 10.1113/jphysiol.1978.sp012416  1
1978 Weingart R, Kass RS, Tsien RW. Is digitalis inotropy associated with enhanced slow inward calcium current? Nature. 273: 389-92. PMID 661951 DOI: 10.1038/273389a0  1
1978 Tsien RW, Kass RS, Weingart R. Calcium ions and membrane current changes induced by digitals in cardiac Purkinje fibers. Annals of the New York Academy of Sciences. 307: 483-90. PMID 360946  1
1978 Tsien RW, Carpenter DO. Ionic mechanisms of pacemaker activity in cardiac Purkinje fibers. Federation Proceedings. 37: 2127-31. PMID 350631  1
1977 Siegelbaum SA, Tsien RW, Kass RS. Role of intracellular calcium in the transient outward current of calf Purkinje fibres. Nature. 269: 611-3. PMID 917108 DOI: 10.1038/269611a0  1
1977 Tsien RW. Cyclic AMP and contractile activity in heart. Advances in Cyclic Nucleotide Research. 8: 363-420. PMID 21550  1
1977 Kass RS, Tsien RW, Weingart R. Strophanthidin can increase the slow inward current and alter its repriming kinetics Biophysical Journal. 17: 4a.  1
1977 Weingart R, Kass RS, Tsien RW. Roles of calcium and sodium ions in the transient inward current induced by strophanthidin in cardiac Purkinje fibers Biophysical Journal. 17: 3a.  1
1976 Kass RS, Tsien RW. Control of action potential duration by calcium ions in cardiac Purkinje fibers. The Journal of General Physiology. 67: 599-617. PMID 1271045  1
1976 Lederer WJ, Tsien RW. Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres. The Journal of Physiology. 263: 73-100. PMID 1018270 DOI: 10.1113/jphysiol.1976.sp011622  1
1976 Kass RS, Siegelbaum S, Tsien RW. Incomplete inactivation of the slow inward current in cardiac Purkinje fibres [proceedings]. The Journal of Physiology. 263: 127P-128P. PMID 1011098  1
1976 Tsien RW, Weingart R. Inotropic effect of cyclic AMP in calf ventricular muscle studied by a cut end method. The Journal of Physiology. 260: 117-41. PMID 184270 DOI: 10.1113/jphysiol.1976.sp011507  1
1976 Kass RS, Kederer WJ, Tsien RW. Current fluctuations in strophanthidin treated cardiac Purkinje fibers Biophysical Journal. 16.  1
1975 McAllister RE, Noble D, Tsien RW. Reconstruction of the electrical activity of cardiac Purkinje fibres. The Journal of Physiology. 251: 1-59. PMID 1185607 DOI: 10.1113/jphysiol.1975.sp011080  1
1975 Kass RS, Tsien RW. Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers. The Journal of General Physiology. 66: 169-92. PMID 1176946  1
1975 Lederer WJ, Tsien RW. Proceedings: Transient inward current underlying strophanthidin's enhancement of pace-maker activity in Purkinje fibres. The Journal of Physiology. 249: 40P-41P. PMID 1151871  1
1975 Giles W, Tsien RW. Effects of acetylcholine on membrane currents in frog artrial muscle. The Journal of Physiology. 246: 64P-66P. PMID 1079874  1
1975 Lederer WJ, Tsien RW. Ionic basis of transient inward current involved in digitalis arrhythmias Circulation. 52.  1
1975 Kass RS, Tsien RW. Analysis of the three microelectrode method as applied to inward currents in cardiac Purkinje fibers Biophysical Journal. 15.  1
1974 McGuigan JA. Some limitations of the double sucrose gap, and its use in a study of the slow outward current in mammalian ventricular muscle. The Journal of Physiology. 240: 775-806. PMID 4415829 DOI: 10.1113/jphysiol.1974.sp010634  1
1974 Tsien RW. Effects of epinephrine on the pacemaker potassium current of cardiac Purkinje fibers. The Journal of General Physiology. 64: 293-319. PMID 4413132  1
1974 Tsien RW, Weingart R. Proceedings: Cyclic AMP: cell-to-cell movement and inotropic effect in ventricular muscle, studied by a cut-end method. The Journal of Physiology. 242: 95P-96P. PMID 4376174  1
1974 Tsien RW. Mode of action of chronotropic agents in cardiac Purkinje fibers. Does epinephrine act by directly modifying the external surface charge? The Journal of General Physiology. 64: 320-42. PMID 4370200  1
1973 Tsien RW. Proceedings: Does adrenaline act by directly modifying the external membrane surface charge of cardiac Purkinje fibres? The Journal of Physiology. 234: 37P-39P. PMID 4767054  1
1973 Tsien RW. Control of conductance in cardiac membrane permeability. Neurosciences Research Program Bulletin. 11: 204-10. PMID 4736776  1
1973 Tsien RW. Adrenaline-like effects of intracellular iontophoresis of cyclic AMP in cardiac Purkinje fibres. Nature: New Biology. 245: 120-2. PMID 4355672  1
1973 Mayer SE, Tsien RW, Rodbell M, Cuatrecasas P. Receptor mechanisms: Hormones and catecholamines Neurosciences Research Program Bulletin. 11: 201-219.  1
1972 Hauswirth O, Noble D, Tsien RW. Separation of the pace-maker and plateau components of delayed rectification in cardiac Purkinje fibres. The Journal of Physiology. 225: 211-35. PMID 4679715 DOI: 10.1113/jphysiol.1972.sp009934  1
1972 Tsien RW, Giles W, Greengard P. Cyclic AMP mediates the effects of adrenaline on cardiac purkinje fibres. Nature: New Biology. 240: 181-3. PMID 4343950  1
1972 Hausworth O, Noble D, Tsien RW. The dependence of plateau currents in cardiac Purkinje fibres on the interval between action potentials. The Journal of Physiology. 222: 27-49. PMID 4113958 DOI: 10.1113/jphysiol.1972.sp009786  1
1969 Tsien RW, Noble D. A transition state theory approach to the kinetics of conductance changes in excitable membranes. The Journal of Membrane Biology. 1: 248-73. PMID 24174053 DOI: 10.1007/BF01869785  1
1969 Hauswirth O, McAllister RE, Noble D, Tsien RW. Reconstruction of the actions of adrenaline and calcium on cardiac pacemaker potentials. The Journal of Physiology. 204: 126P+. PMID 5824627  1
1969 Hauswirth O, Noble D, Tsien RW. The mechanism of oscillatory activity at low membrane potentials in cardiac Purkinje fibres. The Journal of Physiology. 200: 255-65. PMID 5761950 DOI: 10.1113/jphysiol.1969.sp008691  1
1969 Noble D, Tsien RW. Reconstruction of the repolarization process in cardiac Purkinje fibres based on voltage clamp measurements of membrane current. The Journal of Physiology. 200: 233-54. PMID 5761948 DOI: 10.1113/jphysiol.1969.sp008690  1
1969 Noble D, Tsien RW. Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres. The Journal of Physiology. 200: 205-31. PMID 5761944 DOI: 10.1113/jphysiol.1969.sp008689  1
1968 Noble D, Tsien RW. The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres. The Journal of Physiology. 195: 185-214. PMID 5639799 DOI: 10.1113/jphysiol.1968.sp008454  1
1968 Noble D, Tsien RW. Kinetics of slow component of potassium current in cardiac purkinje fibres. The Journal of Physiology. 194: 31P-32P. PMID 5639778  1
1968 Hauswirth O, Noble D, Tsien RW. Adrenaline: mechanism of action on the pacemaker potential in cardiac Purkinje fibers. Science (New York, N.Y.). 162: 916-7. PMID 4386717  1
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