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Heath D. Schmidt - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Addiction, Depression, Neural Circuitry, Dopamine, Glutamate, Epigenetics
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61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Schmidt HD, Zhang Y, Xi J, Zanni G, Liu R, Barr GA. A new formulation of dezocine, Cyc-dezocine, reduces oxycodone self-administration in female and male rats. Neuroscience Letters. 815: 137479. PMID 37714288 DOI: 10.1016/j.neulet.2023.137479  0.567
2023 Zhang Y, Ben Nathan J, Moreno A, Merkel R, Kahng MW, Hayes MR, Reiner BC, Crist RC, Schmidt HD. Calcitonin receptor signaling in nucleus accumbens D1R- and D2R-expressing medium spiny neurons bidirectionally alters opioid taking in male rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 37355732 DOI: 10.1038/s41386-023-01634-z  0.579
2023 Toussaint AB, Ellis AS, Bongiovanni AR, Peterson DR, Bavley CC, Karbalaei R, Mayberry HL, Bhakta S, Dressler CC, Imperio CG, Maurer JJ, Schmidt HD, Chen C, Bland K, Liu-Chen LY, et al. Paternal morphine exposure enhances morphine self-administration and induces region-specific neural adaptations in reward-related brain regions of male offspring. Biorxiv : the Preprint Server For Biology. PMID 36711571 DOI: 10.1101/2023.01.03.522600  0.666
2022 Reiner BC, Zhang Y, Stein LM, Perea ED, Arauco-Shapiro G, Ben Nathan J, Ragnini K, Hayes MR, Ferraro TN, Berrettini WH, Schmidt HD, Crist RC. Single nucleus transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expression associated with volitional morphine intake. Translational Psychiatry. 12: 374. PMID 36075888 DOI: 10.1038/s41398-022-02135-1  0.537
2022 Maurer JJ, Wimmer ME, Turner CA, Herman RJ, Zhang Y, Ragnini K, Ferrante J, Kimmey BA, Crist RC, Christopher Pierce R, Schmidt HD. Paternal nicotine taking elicits heritable sex-specific phenotypes that are mediated by hippocampal Satb2. Molecular Psychiatry. PMID 35595980 DOI: 10.1038/s41380-022-01622-7  0.715
2021 Merkel R, Moreno A, Zhang Y, Herman R, Ben Nathan J, Zeb S, Rahematpura S, Stecyk K, Milliken BT, Hayes MR, Doyle RP, Schmidt HD. A Novel Approach to Treating Opioid Use Disorders: Dual Agonists of Glucagon-like Peptide-1 Receptors and Neuropeptide Y Receptors. Neuroscience and Biobehavioral Reviews. PMID 34715149 DOI: 10.1016/j.neubiorev.2021.10.026  0.53
2021 Zhang Y, Rahematpura S, Ragnini KH, Moreno A, Stecyk KS, Kahng MW, Milliken BT, Hayes MR, Doyle RP, Schmidt HD. A novel dual agonist of glucagon-like peptide-1 receptors and neuropeptide Y2 receptors attenuates fentanyl taking and seeking in male rats. Neuropharmacology. 192: 108599. PMID 33965397 DOI: 10.1016/j.neuropharm.2021.108599  0.589
2021 Angarita GA, Matuskey D, Pittman B, Costeines JL, Potenza MN, Jastreboff AM, Schmidt HD, Malison RT. Testing the effects of the GLP-1 receptor agonist exenatide on cocaine self-administration and subjective responses in humans with cocaine use disorder. Drug and Alcohol Dependence. 221: 108614. PMID 33621809 DOI: 10.1016/j.drugalcdep.2021.108614  0.659
2020 Hernandez NS, Weir VR, Ragnini K, Merkel R, Zhang Y, Mace K, Rich MT, Christopher Pierce R, Schmidt HD. GLP-1 receptor signaling in the laterodorsal tegmental nucleus attenuates cocaine seeking by activating GABAergic circuits that project to the VTA. Molecular Psychiatry. PMID 33257815 DOI: 10.1038/s41380-020-00957-3  0.778
2020 Guercio LA, Wimmer ME, Schmidt HD, Swinford-Jackson SE, Pierce RC, Vassoler FM. Deep brain stimulation of the infralimbic cortex attenuates cocaine priming-induced reinstatement of drug seeking. Brain Research. 1746: 147011. PMID 32652146 DOI: 10.1016/J.Brainres.2020.147011  0.837
2019 Turner C, De Luca M, Wolfheimer J, Hernandez N, Madsen KL, Schmidt HD. Administration of a novel high affinity PICK1 PDZ domain inhibitor attenuates cocaine seeking in rats. Neuropharmacology. 164: 107901. PMID 31805281 DOI: 10.1016/j.neuropharm.2019.107901  0.722
2019 Zhang Y, Kahng MW, Elkind JA, Weir VR, Hernandez NS, Stein LM, Schmidt HD. Activation of GLP-1 receptors attenuates oxycodone taking and seeking without compromising the antinociceptive effects of oxycodone in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31581176 DOI: 10.1038/S41386-019-0531-4  0.648
2019 Hernandez NS, Schmidt HD. Central GLP-1 receptors: Novel molecular targets for cocaine use disorder. Physiology & Behavior. PMID 30930091 DOI: 10.1016/j.physbeh.2019.03.026  0.715
2018 Wimmer ME, Vassoler FM, White SL, Schmidt HD, Sidoli S, Han Y, Garica BA, Pierce RC. Impaired cocaine-induced behavioral plasticity in the male offspring of cocaine-experienced sires. The European Journal of Neuroscience. PMID 30565761 DOI: 10.1111/Ejn.14310  0.869
2018 Hernandez NS, Ige KY, Mietlicki-Baase EG, Molina-Castro GC, Turner CA, Hayes MR, Schmidt HD. Glucagon-like peptide-1 receptor activation in the ventral tegmental area attenuates cocaine seeking in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29497166 DOI: 10.1038/S41386-018-0010-3  0.739
2017 Guercio LA, Hofmann ME, Swinford-Jackson SE, Sigman JS, Wimmer ME, Dell'Acqua ML, Schmidt HD, Pierce RC. A-Kinase Anchoring Protein 150 (AKAP150) Promotes Cocaine Reinstatement by Increasing AMPA Receptor Transmission in the Accumbens Shell. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29317777 DOI: 10.1038/Npp.2017.297  0.877
2017 Hernandez NS, O'Donovan B, Ortinski PI, Schmidt HD. Activation of glucagon-like peptide-1 receptors in the nucleus accumbens attenuates cocaine seeking in rats. Addiction Biology. PMID 29226617 DOI: 10.1111/adb.12583  0.741
2017 Schmidt HD. Cocaine Rearranges the Neuronal Epigenome. Biological Psychiatry. 82: 776-778. PMID 29110817 DOI: 10.1016/j.biopsych.2017.09.016  0.626
2017 Mietlicki-Baase EG, McGrath LE, Koch-Laskowski K, Krawczyk J, Reiner DJ, Pham T, Nguyen CTN, Turner CA, Olivos DR, Wimmer ME, Schmidt HD, Hayes MR. Amylin receptor activation in the ventral tegmental area reduces motivated ingestive behavior. Neuropharmacology. PMID 28552704 DOI: 10.1016/J.Neuropharm.2017.05.024  0.664
2017 Wimmer ME, Briand LA, Fant B, Guercio LA, Arreola AC, Schmidt HD, Sidoli S, Han Y, Garcia BA, Pierce RC. Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny. Molecular Psychiatry. PMID 28322277 DOI: 10.1038/mp.2017.71  0.803
2017 Reiner DJ, Mietlicki-Baase EG, Olivos DR, McGrath LE, Zimmer DJ, Koch-Laskowski K, Krawczyk J, Turner CA, Noble EE, Hahn JD, Schmidt HD, Kanoski SE, Hayes MR. Amylin Acts in the Lateral Dorsal Tegmental Nucleus to Regulate Energy Balance Through Gamma-Aminobutyric Acid Signaling. Biological Psychiatry. PMID 28237459 DOI: 10.1016/J.Biopsych.2016.12.028  0.301
2017 Wimmer ME, Briand LA, Fant B, Guercio LA, Arreola AC, Schmidt HD, Sidoli S, Han Y, Garcia BA, Pierce RC. Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny. Molecular Psychiatry. PMID 28220045 DOI: 10.1038/Mp.2017.8  0.832
2016 Van Nest D, Hernandez NS, Kranzler HR, Pierce RC, Schmidt HD. Effects of LY466195, a selective kainate receptor antagonist, on ethanol preference and drinking in rats. Neuroscience Letters. PMID 28013091 DOI: 10.1016/j.neulet.2016.12.050  0.513
2016 Hayes MR, Schmidt HD. GLP-1 influences food and drug reward. Current Opinion in Behavioral Sciences. 9: 66-70. PMID 27066524 DOI: 10.1016/J.Cobeha.2016.02.005  0.383
2016 Ashare RL, Kimmey BA, Rupprecht LE, Bowers ME, Hayes MR, Schmidt HD. Repeated administration of an acetylcholinesterase inhibitor attenuates nicotine taking in rats and smoking behavior in human smokers. Translational Psychiatry. 6: e713. PMID 26784967 DOI: 10.1038/Tp.2015.209  0.31
2015 Schmidt HD, Mietlicki-Baase EG, Ige KY, Maurer JJ, Reiner DJ, Zimmer DJ, Van Nest DS, Guercio LA, Wimmer ME, Olivos DR, De Jonghe BC, Hayes MR. Glucagon-Like Peptide-1 Receptor Activation in the Ventral Tegmental Area Decreases the Reinforcing Efficacy of Cocaine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26675243 DOI: 10.1038/Npp.2015.362  0.865
2015 White SL, Ortinski PI, Friedman SH, Zhang L, Neve RL, Kalb RG, Schmidt HD, Pierce RC. A Critical Role for the GluA1 Accessory Protein, SAP97, in Cocaine Seeking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26149358 DOI: 10.1038/Npp.2015.199  0.794
2015 White SL, Vassoler FM, Schmidt HD, Pierce RC, Wimmer ME. Enhanced anxiety in the male offspring of sires that self-administered cocaine. Addiction Biology. PMID 25923597 DOI: 10.1111/Adb.12258  0.853
2015 Ortinski PI, Briand LA, Pierce RC, Schmidt HD. Cocaine-seeking is associated with PKC-dependent reduction of excitatory signaling in accumbens shell D2 dopamine receptor-expressing neurons. Neuropharmacology. 92: 80-9. PMID 25596492 DOI: 10.1016/j.neuropharm.2015.01.002  0.773
2015 Guercio LA, Schmidt HD, Pierce RC. Deep brain stimulation of the nucleus accumbens shell attenuates cue-induced reinstatement of both cocaine and sucrose seeking in rats. Behavioural Brain Research. 281: 125-30. PMID 25529183 DOI: 10.1016/j.bbr.2014.12.025  0.796
2015 Schmidt HD, Kimmey BA, Arreola AC, Pierce RC. Group I metabotropic glutamate receptor-mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking. Addiction Biology. 20: 285-96. PMID 24506432 DOI: 10.1111/adb.12122  0.814
2014 Schmidt HD, McFarland KN, Darnell SB, Huizenga MN, Sangrey GR, Cha JH, Pierce RC, Sadri-Vakili G. ADAR2-dependent GluA2 editing regulates cocaine seeking. Molecular Psychiatry. PMID 25349168 DOI: 10.1038/mp.2014.134  0.759
2014 Lee AM, Arreola AC, Kimmey BA, Schmidt HD. Administration of the nicotinic acetylcholine receptor agonists ABT-089 and ABT-107 attenuates the reinstatement of nicotine-seeking behavior in rats. Behavioural Brain Research. 274: 168-75. PMID 25128791 DOI: 10.1016/j.bbr.2014.08.016  0.364
2014 Rasakham K, Schmidt HD, Kay K, Huizenga MN, Calcagno N, Pierce RC, Spires-Jones TL, Sadri-Vakili G. Synapse density and dendritic complexity are reduced in the prefrontal cortex following seven days of forced abstinence from cocaine self-administration. Plos One. 9: e102524. PMID 25072653 DOI: 10.1371/Journal.Pone.0102524  0.773
2014 Kimmey BA, Rupprecht LE, Hayes MR, Schmidt HD. Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats. Addiction Biology. 19: 539-51. PMID 23231479 DOI: 10.1111/Adb.12014  0.35
2013 Vassoler FM, White SL, Hopkins TJ, Guercio LA, Espallergues J, Berton O, Schmidt HD, Pierce RC. Deep brain stimulation of the nucleus accumbens shell attenuates cocaine reinstatement through local and antidromic activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 14446-54. PMID 24005296 DOI: 10.1523/JNEUROSCI.4804-12.2013  0.729
2013 Schmidt HD, Schassburger RL, Guercio LA, Pierce RC. Stimulation of mGluR5 in the accumbens shell promotes cocaine seeking by activating PKC gamma. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 14160-9. PMID 23986250 DOI: 10.1523/JNEUROSCI.2284-13.2013  0.768
2013 Mietlicki-Baase EG, Rupprecht LE, Olivos DR, Zimmer DJ, Alter MD, Pierce RC, Schmidt HD, Hayes MR. Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 1685-97. PMID 23474592 DOI: 10.1038/Npp.2013.66  0.521
2013 Schmidt HD, McGinty JF, West AE, Sadri-Vakili G. Epigenetics and psychostimulant addiction. Cold Spring Harbor Perspectives in Medicine. 3: a012047. PMID 23359110 DOI: 10.1101/cshperspect.a012047  0.393
2013 White SL, Schmidt HD, Vassoler FM, Pierce RC. Acute cocaine increases phosphorylation of CaMKII and GluA1 in the dorsolateral striatum of drug naïve rats, but not cocaine-experienced rats. Neuroscience Letters. 537: 71-6. PMID 23352852 DOI: 10.1016/j.neulet.2013.01.017  0.812
2013 Vassoler FM, White SL, Schmidt HD, Sadri-Vakili G, Pierce RC. Epigenetic inheritance of a cocaine-resistance phenotype. Nature Neuroscience. 16: 42-7. PMID 23242310 DOI: 10.1038/nn.3280  0.798
2013 Schmidt HD, Pierce RC. The Role of Glutamate Receptors in Addiction Biological Research On Addiction. 241-250. DOI: 10.1016/B978-0-12-398335-0.00025-X  0.484
2012 Hopkins TJ, Rupprecht LE, Hayes MR, Blendy JA, Schmidt HD. Galantamine, an acetylcholinesterase inhibitor and positive allosteric modulator of nicotinic acetylcholine receptors, attenuates nicotine taking and seeking in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2310-21. PMID 22669169 DOI: 10.1038/Npp.2012.83  0.355
2012 Schmidt HD, Sangrey GR, Darnell SB, Schassburger RL, Cha JH, Pierce RC, Sadri-Vakili G. Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters. Journal of Neurochemistry. 120: 202-9. PMID 22043863 DOI: 10.1111/j.1471-4159.2011.07571.x  0.791
2011 Chen YI, Famous K, Xu H, Choi JK, Mandeville JB, Schmidt HD, Pierce RC, Jenkins BG. Cocaine self-administration leads to alterations in temporal responses to cocaine challenge in limbic and motor circuitry. The European Journal of Neuroscience. 34: 800-15. PMID 21896062 DOI: 10.1111/J.1460-9568.2011.07806.X  0.883
2011 Yee J, Famous KR, Hopkins TJ, McMullen MC, Pierce RC, Schmidt HD. Muscarinic acetylcholine receptors in the nucleus accumbens core and shell contribute to cocaine priming-induced reinstatement of drug seeking. European Journal of Pharmacology. 650: 596-604. PMID 21034738 DOI: 10.1016/J.Ejphar.2010.10.045  0.89
2010 Sadri-Vakili G, Kumaresan V, Schmidt HD, Famous KR, Chawla P, Vassoler FM, Overland RP, Xia E, Bass CE, Terwilliger EF, Pierce RC, Cha JH. Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11735-44. PMID 20810894 DOI: 10.1523/Jneurosci.2328-10.2010  0.862
2010 Schmidt HD, Pierce RC. Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction. Annals of the New York Academy of Sciences. 1187: 35-75. PMID 20201846 DOI: 10.1111/j.1749-6632.2009.05144.x  0.804
2009 Schmidt HD, Famous KR, Pierce RC. The limbic circuitry underlying cocaine seeking encompasses the PPTg/LDT. The European Journal of Neuroscience. 30: 1358-69. PMID 19788581 DOI: 10.1111/J.1460-9568.2009.06904.X  0.894
2009 Kumaresan V, Yuan M, Yee J, Famous KR, Anderson SM, Schmidt HD, Pierce RC. Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking. Behavioural Brain Research. 202: 238-44. PMID 19463707 DOI: 10.1016/J.Bbr.2009.03.039  0.872
2008 Famous KR, Kumaresan V, Sadri-Vakili G, Schmidt HD, Mierke DF, Cha JH, Pierce RC. Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11061-70. PMID 18945913 DOI: 10.1523/Jneurosci.1221-08.2008  0.875
2008 Vassoler FM, Schmidt HD, Gerard ME, Famous KR, Ciraulo DA, Kornetsky C, Knapp CM, Pierce RC. Deep brain stimulation of the nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug seeking in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 8735-9. PMID 18753374 DOI: 10.1523/Jneurosci.5277-07.2008  0.887
2008 Anderson SM, Famous KR, Sadri-Vakili G, Kumaresan V, Schmidt HD, Bass CE, Terwilliger EF, Cha JH, Pierce RC. CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking. Nature Neuroscience. 11: 344-53. PMID 18278040 DOI: 10.1038/Nn2054  0.858
2008 Anderson SM, Famous KR, Sadri-Vakili G, Kumaresan V, Schmidt HD, Bass CE, Terwilliger EF, Cha JHJ, Pierce RC. CaMKII: A biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking (Nature Neuroscience (2008) 11, 344-353) Nature Neuroscience. 11: 617. DOI: 10.1038/Nn0508-617  0.846
2007 Famous KR, Schmidt HD, Pierce RC. When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat. Neuroscience Letters. 420: 169-73. PMID 17513051 DOI: 10.1016/J.Neulet.2007.04.063  0.883
2006 Schmidt HD, Pierce RC. Systemic administration of a dopamine, but not a serotonin or norepinephrine, transporter inhibitor reinstates cocaine seeking in the rat. Behavioural Brain Research. 175: 189-94. PMID 16978714 DOI: 10.1016/j.bbr.2006.08.009  0.776
2006 Schmidt HD, Pierce RC. Cooperative activation of D1-like and D2-like dopamine receptors in the nucleus accumbens shell is required for the reinstatement of cocaine-seeking behavior in the rat. Neuroscience. 142: 451-61. PMID 16844308 DOI: 10.1016/j.neuroscience.2006.06.004  0.716
2006 Schmidt HD, Anderson SM, Pierce RC. Stimulation of D1-like or D2 dopamine receptors in the shell, but not the core, of the nucleus accumbens reinstates cocaine-seeking behaviour in the rat. The European Journal of Neuroscience. 23: 219-28. PMID 16420431 DOI: 10.1111/J.1460-9568.2005.04524.X  0.796
2006 Anderson SM, Schmidt HD, Pierce RC. Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1452-61. PMID 16205775 DOI: 10.1038/Sj.Npp.1300922  0.852
2005 Schmidt HD, Anderson SM, Famous KR, Kumaresan V, Pierce RC. Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking. European Journal of Pharmacology. 526: 65-76. PMID 16321382 DOI: 10.1016/J.Ejphar.2005.09.068  0.865
2004 Licata SC, Schmidt HD, Pierce RC. Suppressing calcium/calmodulin-dependent protein kinase II activity in the ventral tegmental area enhances the acute behavioural response to cocaine but attenuates the initiation of cocaine-induced behavioural sensitization in rats. The European Journal of Neuroscience. 19: 405-14. PMID 14725635 DOI: 10.1111/j.0953-816X.2003.03110.x  0.718
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