Teepu Siddique - Publications

Northwestern University, Evanston, IL 
ALS, Neurogenetics, Neurobiology of disease

152 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Opie-Martin S, Iacoangeli A, Topp SD, Abel O, Mayl K, Mehta PR, Shatunov A, Fogh I, Bowles H, Limbachiya N, Spargo TP, Al-Khleifat A, Williams KL, Jockel-Balsarotti J, Bali T, ... ... Siddique T, et al. The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration. Nature Communications. 13: 6901. PMID 36371497 DOI: 10.1038/s41467-022-34620-y  0.322
2020 Silani V, Corcia P, Harms MB, Rouleau G, Siddique T, Ticozzi N. Genetics of primary lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 21: 28-34. PMID 33602012 DOI: 10.1080/21678421.2020.1837177  0.427
2020 Lowry JL, Ryan ÉB, Esengul YT, Siddique N, Siddique T. Intricacies of aetiology in intrafamilial degenerative disease. Brain Communications. 2: fcaa120. PMID 33134917 DOI: 10.1093/braincomms/fcaa120  0.791
2020 Pytte J, Flynn LL, Anderton RS, Mastaglia FL, Theunissen F, James I, Pfaff A, Koks S, Saunders AM, Bedlack R, Burns DK, Lutz MW, Siddique N, Siddique T, Roses AD, et al. Disease-modifying effects of an structural variant in a predominantly ALS cohort. Neurology. Genetics. 6: e470. PMID 32754644 DOI: 10.1212/Nxg.0000000000000470  0.549
2020 Wu JJ, Cai A, Greenslade JE, Higgins NR, Fan C, Le NTT, Tatman M, Whiteley AM, Prado MA, Dieriks BV, Curtis MA, Shaw CE, Siddique T, Faull RLM, Scotter EL, et al. ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function. Proceedings of the National Academy of Sciences of the United States of America. PMID 32513711 DOI: 10.1073/pnas.1917371117  0.507
2020 Pytte J, Anderton RS, Flynn LL, Theunissen F, Jiang L, Pitout I, James I, Mastaglia FL, Saunders AM, Bedlack R, Siddique T, Siddique N, Akkari PA. Association of a structural variant within the gene with amyotrophic lateral sclerosis. Neurology. Genetics. 6: e406. PMID 32185242 DOI: 10.1212/Nxg.0000000000000406  0.375
2020 Ortega JA, Daley EL, Kour S, Samani M, Tellez L, Smith HS, Hall EA, Esengul YT, Tsai YH, Gendron TF, Donnelly CJ, Siddique T, Savas JN, Pandey UB, Kiskinis E. Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity. Neuron. PMID 32059759 DOI: 10.1016/J.Neuron.2020.01.020  0.78
2019 Deng S, Feely SME, Shi Y, Zhai H, Zhan L, Siddique T, Deng HX, Shy ME. Incidence and Clinical Features of TRPV4-Linked Axonal Neuropathies in a USA Cohort of Charcot-Marie-Tooth Disease Type 2. Neuromolecular Medicine. PMID 31468327 DOI: 10.1007/s12017-019-08564-4  0.435
2019 Deng HX, Pericak-Vance MA, Siddique T. Reply to 'TMEM230 variants in Parkinson's disease' and 'Doubts about TMEM230 as a gene for parkinsonism'. Nature Genetics. PMID 30804556 DOI: 10.1038/S41588-019-0355-5  0.331
2017 Edens BM, Yan J, Deng HX, Siddique T, Ma YC. A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis. Elife. 6. PMID 28463112 DOI: 10.7554/eLife.25453  0.386
2017 Zhong Y, Wang J, Henderson MJ, Yang P, Hagen BM, Siddique T, Vogel BE, Deng HX, Fang S. Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus. Elife. 6. PMID 28463106 DOI: 10.7554/Elife.23759  0.409
2017 Kim MJ, Deng HX, Wong YC, Siddique T, Krainc D. The Parkinson's disease-linked protein TMEM230 is required for Rab8a-mediated secretory vesicle trafficking and retromer trafficking. Human Molecular Genetics. PMID 28115417 DOI: 10.1093/Hmg/Ddw413  0.302
2017 Edens BM, Yan J, Miller N, Deng H, Siddique T, Ma YC. Author response: A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis Elife. DOI: 10.7554/Elife.25453.012  0.329
2016 Radzicki D, Liu E, Deng HX, Siddique T, Martina M. Early Impairment of Synaptic and Intrinsic Excitability in Mice Expressing ALS/Dementia-Linked Mutant UBQLN2. Frontiers in Cellular Neuroscience. 10: 216. PMID 27703430 DOI: 10.3389/Fncel.2016.00216  0.36
2016 Simonett JM, Huang R, Siddique N, Farsiu S, Siddique T, Volpe NJ, Fawzi AA. Macular sub-layer thinning and association with pulmonary function tests in Amyotrophic Lateral Sclerosis. Scientific Reports. 6: 29187. PMID 27383525 DOI: 10.1038/Srep29187  0.311
2016 Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovičić A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, et al. Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis. Neuron. PMID 27321923 DOI: 10.1016/J.Neuron.2016.05.021  0.379
2016 Deng HX, Shi Y, Yang Y, Ahmeti KB, Miller N, Huang C, Cheng L, Zhai H, Deng S, Nuytemans K, Corbett NJ, Kim MJ, Deng H, Tang B, Yang Z, ... ... Siddique T, et al. Identification of TMEM230 mutations in familial Parkinson's disease. Nature Genetics. PMID 27270108 DOI: 10.1038/Ng.3589  0.789
2016 Bali T, Self W, Liu J, Siddique T, Wang LH, Bird TD, Ratti E, Atassi N, Boylan KB, Glass JD, Maragakis NJ, Caress JB, McCluskey LF, Appel SH, Wymer JP, et al. Defining SOD1 ALS natural history to guide therapeutic clinical trial design. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 27261500 DOI: 10.1136/Jnnp-2016-313521  0.448
2016 Yang Y, Zhang L, Lynch DR, Lukas T, Ahmeti K, Sleiman PM, Ryan E, Schadt KA, Newman JH, Deng HX, Siddique N, Siddique T. Compound heterozygote mutations in SPG7 in a family with adult-onset primary lateral sclerosis. Neurology. Genetics. 2: e60. PMID 27123479 DOI: 10.1212/Nxg.0000000000000060  0.795
2015 Arrat H, Lukas TJ, Siddique T. ACTH (Acthar Gel) Reduces Toxic SOD1 Protein Linked to Amyotrophic Lateral Sclerosis in Transgenic Mice: A Novel Observation. Plos One. 10: e0125638. PMID 25955410 DOI: 10.1371/journal.pone.0125638  0.415
2015 Hartzfeld DE, Siddique N, Victorson D, O'Neill S, Kinsley L, Siddique T. Reproductive decision-making among individuals at risk for familial amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 16: 114-9. PMID 25204983 DOI: 10.3109/21678421.2014.951945  0.344
2015 Ajroud-Driss S, Fecto F, Ajroud K, Lalani I, Calvo SE, Mootha VK, Deng HX, Siddique N, Tahmoush AJ, Heiman-Patterson TD, Siddique T. Mutation in the novel nuclear-encoded mitochondrial protein CHCHD10 in a family with autosomal dominant mitochondrial myopathy. Neurogenetics. 16: 1-9. PMID 25193783 DOI: 10.1007/S10048-014-0421-1  0.798
2015 Ajroud-Driss S, Siddique T. Sporadic and hereditary amyotrophic lateral sclerosis (ALS). Biochimica Et Biophysica Acta. 1852: 679-684. PMID 25193032 DOI: 10.1016/J.Bbadis.2014.08.010  0.49
2014 Gallardo G, Barowski J, Ravits J, Siddique T, Lingrel JB, Robertson J, Steen H, Bonni A. An α2-Na/K ATPase/α-adducin complex in astrocytes triggers non-cell autonomous neurodegeneration. Nature Neuroscience. 17: 1710-9. PMID 25344630 DOI: 10.1038/Nn.3853  0.318
2014 Fawzi AA, Simonett JM, Purta P, Moss HE, Lowry JL, Deng HX, Siddique N, Sufit R, Bigio EH, Volpe NJ, Siddique T. Clinicopathologic report of ocular involvement in ALS patients with C9orf72 mutation. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 15: 569-80. PMID 25319030 DOI: 10.3109/21678421.2014.951941  0.449
2014 Gorrie GH, Fecto F, Radzicki D, Weiss C, Shi Y, Dong H, Zhai H, Fu R, Liu E, Li S, Arrat H, Bigio EH, Disterhoft JF, Martina M, Mugnaini E, ... Siddique T, et al. Dendritic spinopathy in transgenic mice expressing ALS/dementia-linked mutant UBQLN2. Proceedings of the National Academy of Sciences of the United States of America. 111: 14524-9. PMID 25246588 DOI: 10.1073/Pnas.1405741111  0.811
2014 Fecto F, Esengul YT, Siddique T. Protein recycling pathways in neurodegenerative diseases. Alzheimer's Research & Therapy. 6: 13. PMID 25031631 DOI: 10.1186/alzrt243  0.748
2014 Koschnitzky JE, Quinlan KA, Lukas TJ, Kajtaz E, Kocevar EJ, Mayers WF, Siddique T, Heckman CJ. Effect of fluoxetine on disease progression in a mouse model of ALS. Journal of Neurophysiology. 111: 2164-76. PMID 24598527 DOI: 10.1152/Jn.00425.2013  0.347
2014 Lukas TJ, Schiltz GE, Arrat H, Scheidt K, Siddique T. Discovery of 1,3,4-oxidiazole scaffold compounds as inhibitors of superoxide dismutase expression. Bioorganic & Medicinal Chemistry Letters. 24: 1532-7. PMID 24560539 DOI: 10.1016/J.Bmcl.2014.01.078  0.467
2014 Wang X, Blanchard J, Grundke-Iqbal I, Wegiel J, Deng HX, Siddique T, Iqbal K. Alzheimer disease and amyotrophic lateral sclerosis: an etiopathogenic connection. Acta Neuropathologica. 127: 243-56. PMID 24136402 DOI: 10.1007/S00401-013-1175-9  0.386
2013 Al-Chalabi A, Kwak S, Mehler M, Rouleau G, Siddique T, Strong M, Leigh PN. Genetic and epigenetic studies of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 44-52. PMID 23678879 DOI: 10.3109/21678421.2013.778571  0.391
2013 Bigio EH, Wu JY, Deng HX, Bit-Ivan EN, Mao Q, Ganti R, Peterson M, Siddique N, Geula C, Siddique T, Mesulam M. Inclusions in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), but not FTLD with FUS proteinopathy (FTLD-FUS), have properties of amyloid. Acta Neuropathologica. 125: 463-5. PMID 23378033 DOI: 10.1007/S00401-013-1089-6  0.376
2013 Allen JA, Chen R, Ajroud-Driss S, Sufit RL, Heller S, Siddique T, Wolfe L. Gastrostomy tube placement by endoscopy versus radiologic methods in patients with ALS: a retrospective study of complications and outcome. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 308-14. PMID 23286755 DOI: 10.3109/21678421.2012.751613  0.324
2013 Ahmeti KB, Ajroud-Driss S, Al-Chalabi A, Andersen PM, Armstrong J, Birve A, Blauw HM, Brown RH, Bruijn L, Chen W, Chio A, Comeau MC, Cronin S, Diekstra FP, Soraya Gkazi A, ... ... Siddique T, et al. Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. Neurobiology of Aging. 34: 357.e7-19. PMID 22959728 DOI: 10.1016/j.neurobiolaging.2012.07.017  0.8
2012 Kwan JY, Jeong SY, Van Gelderen P, Deng HX, Quezado MM, Danielian LE, Butman JA, Chen L, Bayat E, Russell J, Siddique T, Duyn JH, Rouault TA, Floeter MK. Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 tesla MRI and pathology. Plos One. 7: e35241. PMID 22529995 DOI: 10.1371/Journal.Pone.0035241  0.327
2012 Fecto F, Siddique T. UBQLN2/P62 cellular recycling pathways in amyotrophic lateral sclerosis and frontotemporal dementia. Muscle & Nerve. 45: 157-62. PMID 22246868 DOI: 10.1002/mus.23278  0.824
2012 Fecto F, Siddique T. What is repeated in ALS and FTLD. The Lancet. Neurology. 11: 25-7. PMID 22154784 DOI: 10.1016/S1474-4422(11)70275-7  0.8
2012 Fecto F, Deng H, Chen W, Hong S, Boycott K, Gorrie G, Siddique N, Yang Y, Shi Y, Zhai H, Jiang H, Hirano M, Rampersaud E, Jansen G, Donkervoort S, ... ... Siddique T, et al. UBQLN2 Mutations in ALS and ALS/Dementia: A Genetic, Functional and Histopathological Analysis (S05.006) Neurology. 78: S05.006-S05.006. DOI: 10.1212/Wnl.78.1_Meetingabstracts.S05.006  0.83
2012 Fecto F, Gorrie G, Zhai H, Radzicki D, Fu R, Liu E, Weiss C, Martina M, Disterhoft J, Mugnaini E, Siddique T, Deng H. Mutant UBQLN2 Transgenic Mice Recapitulate Behavioral, Pathological and Neurophysiological Characteristics of Human Ubiqulinopathy (P05.165) Neurology. 78: P05.165-P05.165. DOI: 10.1212/Wnl.78.1_Meetingabstracts.P05.165  0.76
2012 Fecto F, Esengul YT, Deng H, Siddique T. Autophagy Is Impaired by UBQLN2 Mutations Linked to ALS/FTD (P05.164) Neurology. 78: P05.164-P05.164. DOI: 10.1212/wnl.78.1_meetingabstracts.p05.164  0.78
2012 Allen J, Hall M, Wallery S, Ajroud-Driss S, Armstrong J, McManus C, Cook T, Sufit R, Chrisman H, Wolfe L, Siddique T. Gastrostomy Tube Placement by Endoscopy Versus Radiologic Methods in Patients with ALS: A Retrospective Review of Complications and Outcome (P01.101) Neurology. 78: P01.101-P01.101. DOI: 10.1212/Wnl.78.1_Meetingabstracts.P01.101  0.314
2012 Ajroud-Driss S, Fecto F, Ajroud K, Siddique T. Mutations in the Nuclear Encoded Novel Mitochondrial Protein CHCHD10 Cause an Autosomal Dominant Mitochondrial Myopathy (IN7-2.002) Neurology. 78: IN7-2.002-IN7-2.002. DOI: 10.1212/Wnl.78.1_Meetingabstracts.In7-2.002  0.801
2011 Fecto F, Siddique T. SIGMAR1 mutations, genetic heterogeneity at the chromosome 9p locus, and the expanding etiological diversity of amyotrophic lateral sclerosis. Annals of Neurology. 70: 867-70. PMID 22190360 DOI: 10.1002/ana.22648  0.809
2011 Siddique T, Ajroud-Driss S. Familial amyotrophic lateral sclerosis, a historical perspective. Acta Myologica : Myopathies and Cardiomyopathies : Official Journal of the Mediterranean Society of Myology / Edited by the Gaetano Conte Academy For the Study of Striated Muscle Diseases. 30: 117-20. PMID 22106714  0.392
2011 Fecto F, Yan J, Vemula SP, Liu E, Yang Y, Chen W, Zheng JG, Shi Y, Siddique N, Arrat H, Donkervoort S, Ajroud-Driss S, Sufit RL, Heller SL, Deng HX, ... Siddique T, et al. SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis. Archives of Neurology. 68: 1440-6. PMID 22084127 DOI: 10.1001/Archneurol.2011.250  0.846
2011 Fecto F, Siddique T. Making connections: pathology and genetics link amyotrophic lateral sclerosis with frontotemporal lobe dementia. Journal of Molecular Neuroscience : Mn. 45: 663-75. PMID 21901496 DOI: 10.1007/s12031-011-9637-9  0.83
2011 Deng HX, Chen W, Hong ST, Boycott KM, Gorrie GH, Siddique N, Yang Y, Fecto F, Shi Y, Zhai H, Jiang H, Hirano M, Rampersaud E, Jansen GH, Donkervoort S, ... ... Siddique T, et al. Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature. 477: 211-5. PMID 21857683 DOI: 10.1038/Nature10353  0.841
2011 Deng HX, Bigio EH, Zhai H, Fecto F, Ajroud K, Shi Y, Yan J, Mishra M, Ajroud-Driss S, Heller S, Sufit R, Siddique N, Mugnaini E, Siddique T. Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations. Archives of Neurology. 68: 1057-61. PMID 21825243 DOI: 10.1001/Archneurol.2011.178  0.834
2011 Subramony SH, Ashizawa T, Langford L, McKenna R, Avvaru B, Siddique T, Vedanarayanan V. Confirmation of the severe phenotypic effect of serine at codon 41 of the superoxide dismutase 1 gene. Muscle & Nerve. 44: 499-502. PMID 21755517 DOI: 10.1002/Mus.22117  0.51
2011 Quinlan KA, Schuster JE, Fu R, Siddique T, Heckman CJ. Altered postnatal maturation of electrical properties in spinal motoneurons in a mouse model of amyotrophic lateral sclerosis. The Journal of Physiology. 589: 2245-60. PMID 21486770 DOI: 10.1113/Jphysiol.2010.200659  0.335
2011 Fecto F, Shi Y, Huda R, Martina M, Siddique T, Deng HX. Mutant TRPV4-mediated toxicity is linked to increased constitutive function in axonal neuropathies. The Journal of Biological Chemistry. 286: 17281-91. PMID 21454511 DOI: 10.1074/Jbc.M111.237685  0.764
2011 Ajroud-Driss S, Deng HX, Siddique T. Recent advances in the genetics of hereditary axonal sensory-motor neuropathies type 2. Current Neurology and Neuroscience Reports. 11: 262-73. PMID 21327736 DOI: 10.1007/S11910-011-0185-Z  0.352
2011 Klein CJ, Shi Y, Fecto F, Donaghy M, Nicholson G, McEntagart ME, Crosby AH, Wu Y, Lou H, McEvoy KM, Siddique T, Deng HX, Dyck PJ. TRPV4 mutations and cytotoxic hypercalcemia in axonal Charcot-Marie-Tooth neuropathies. Neurology. 76: 887-94. PMID 21288981 DOI: 10.1212/Wnl.0B013E31820F2De3  0.805
2010 Yan J, Deng HX, Siddique N, Fecto F, Chen W, Yang Y, Liu E, Donkervoort S, Zheng JG, Shi Y, Ahmeti KB, Brooks B, Engel WK, Siddique T. Frameshift and novel mutations in FUS in familial amyotrophic lateral sclerosis and ALS/dementia. Neurology. 75: 807-14. PMID 20668259 DOI: 10.1212/Wnl.0B013E3181F07E0C  0.805
2010 Yasser S, Fecto F, Siddique T, Sheikh KA, Athar P. An unusual case of familial ALS and cerebellar ataxia. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 11: 568-70. PMID 20540686 DOI: 10.3109/17482961003636874  0.809
2010 Deng HX, Zhai H, Bigio EH, Yan J, Fecto F, Ajroud K, Mishra M, Ajroud-Driss S, Heller S, Sufit R, Siddique N, Mugnaini E, Siddique T. FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis. Annals of Neurology. 67: 739-48. PMID 20517935 DOI: 10.1002/Ana.22051  0.83
2010 Deng HX, Klein CJ, Yan J, Shi Y, Wu Y, Fecto F, Yau HJ, Yang Y, Zhai H, Siddique N, Hedley-Whyte ET, Delong R, Martina M, Dyck PJ, Siddique T. Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4. Nature Genetics. 42: 165-9. PMID 20037587 DOI: 10.1038/Ng.509  0.808
2010 Zhou J, Yi J, Fu R, Liu E, Siddique T, Ríos E, Deng HX. Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis. The Journal of Biological Chemistry. 285: 705-12. PMID 19889637 DOI: 10.1074/Jbc.M109.041319  0.341
2010 Schüle R, Siddique T, Deng HX, Yang Y, Donkervoort S, Hansson M, Madrid RE, Siddique N, Schöls L, Björkhem I. Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. Journal of Lipid Research. 51: 819-23. PMID 19812052 DOI: 10.1194/jlr.M002543  0.321
2010 Fecto F, Deng HX, Siddique T. Discovering the connection between familial and sporadic amyotrophic lateral sclerosis: Pathology trumps genetics Future Neurology. 5: 625-628. DOI: 10.2217/fnl.10.47  0.8
2009 Jiang M, Schuster JE, Fu R, Siddique T, Heckman CJ. Progressive changes in synaptic inputs to motoneurons in adult sacral spinal cord of a mouse model of amyotrophic lateral sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15031-8. PMID 19955354 DOI: 10.1523/Jneurosci.0574-09.2009  0.325
2009 Ajroud-Driss S, Fecto F, Ajroud K, Yang Y, Donkervoort S, Siddique N, Siddique T. A novel de novo MFN2 mutation causing CMT2A with upper motor neuron signs. Neurogenetics. 10: 359-61. PMID 19350291 DOI: 10.1007/S10048-009-0188-Y  0.793
2009 Kwiatkowski TJ, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, ... ... Siddique T, et al. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science (New York, N.Y.). 323: 1205-8. PMID 19251627 DOI: 10.1126/Science.1166066  0.516
2009 Wang L, Deng HX, Grisotti G, Zhai H, Siddique T, Roos RP. Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse. Human Molecular Genetics. 18: 1642-51. PMID 19233858 DOI: 10.1093/Hmg/Ddp085  0.621
2009 Saeed M, Yang Y, Deng HX, Hung WY, Siddique N, Dellefave L, Gellera C, Andersen PM, Siddique T. Age and founder effect of SOD1 A4V mutation causing ALS. Neurology. 72: 1634-9. PMID 19176896 DOI: 10.1212/01.wnl.0000343509.76828.2a  0.448
2009 Lambrechts D, Poesen K, Fernández-Santiago R, Al-Chalabi A, Del Bo R, Van Vught PW, Khan S, Marklund SL, Brockington A, van Marion I, Anneser J, Shaw C, Ludolph AC, Leigh NP, Comi GP, ... ... Siddique T, et al. Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the -2578AA genotype. Journal of Medical Genetics. 46: 840-6. PMID 18413368 DOI: 10.1136/jmg.2008.058222  0.393
2008 Siddique N, Siddique T. Genetics of amyotrophic lateral sclerosis. Physical Medicine and Rehabilitation Clinics of North America. 19: 429-39, vii. PMID 18625408 DOI: 10.1016/j.pmr.2008.05.001  0.436
2008 Frutiger K, Lukas TJ, Gorrie G, Ajroud-Driss S, Siddique T. Gender difference in levels of Cu/Zn superoxide dismutase (SOD1) in cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 9: 184-7. PMID 18574763 DOI: 10.1080/17482960801984358  0.412
2008 Deng HX, Han-Xiang D, Jiang H, Hujun J, Fu R, Ronggen F, Zhai H, Hong Z, Shi Y, Yong S, Liu E, Erdong L, Hirano M, Makito H, Dal Canto MC, ... ... Siddique T, et al. Molecular dissection of ALS-associated toxicity of SOD1 in transgenic mice using an exon-fusion approach. Human Molecular Genetics. 17: 2310-9. PMID 18424447 DOI: 10.1093/HMG/DDN368  0.492
2008 Siddique T. What is missing in ALS. The Lancet. Neurology. 7: 289-90. PMID 18313987 DOI: 10.1016/S1474-4422(08)70049-8  0.391
2008 Tsaousidou MK, Ouahchi K, Warner TT, Yang Y, Simpson MA, Laing NG, Wilkinson PA, Madrid RE, Patel H, Hentati F, Patton MA, Hentati A, Lamont PJ, Siddique T, Crosby AH. Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration. American Journal of Human Genetics. 82: 510-5. PMID 18252231 DOI: 10.1016/J.Ajhg.2007.10.001  0.362
2008 Wang L, Sharma K, Deng HX, Siddique T, Grisotti G, Liu E, Roos RP. Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology. Neurobiology of Disease. 29: 400-8. PMID 18054242 DOI: 10.1016/J.Nbd.2007.10.004  0.637
2007 Deng HX, Zhai H, Fu R, Shi Y, Gorrie GH, Yang Y, Liu E, Dal Canto MC, Mugnaini E, Siddique T. Distal axonopathy in an alsin-deficient mouse model. Human Molecular Genetics. 16: 2911-20. PMID 17855450 DOI: 10.1093/Hmg/Ddm251  0.392
2007 Ajroud-Driss S, Saeed M, Khan H, Siddique N, Hung WY, Sufit R, Heller S, Armstrong J, Casey P, Siddique T, Lukas TJ. Riluzole metabolism and CYP1A1/2 polymorphisms in patients with ALS. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 8: 305-9. PMID 17852022 DOI: 10.1080/17482960701500650  0.316
2007 Mishra M, Paunesku T, Woloschak GE, Siddique T, Zhu LJ, Lin S, Greco K, Bigio EH. Gene expression analysis of frontotemporal lobar degeneration of the motor neuron disease type with ubiquitinated inclusions. Acta Neuropathologica. 114: 81-94. PMID 17569064 DOI: 10.1007/S00401-007-0240-7  0.332
2007 Mackenzie IR, Bigio EH, Ince PG, Geser F, Neumann M, Cairns NJ, Kwong LK, Forman MS, Ravits J, Stewart H, Eisen A, McClusky L, Kretzschmar HA, Monoranu CM, Highley JR, ... ... Siddique T, et al. Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Annals of Neurology. 61: 427-34. PMID 17469116 DOI: 10.1002/Ana.21147  0.528
2006 Chen W, Saeed M, Mao H, Siddique N, Dellefave L, Hung WY, Deng HX, Sufit RL, Heller SL, Haines JL, Pericak-Vance M, Siddique T. Lack of association of VEGF promoter polymorphisms with sporadic ALS. Neurology. 67: 508-10. PMID 16894118 DOI: 10.1212/01.Wnl.0000227926.42370.04  0.337
2006 Saeed M, Siddique N, Hung WY, Usacheva E, Liu E, Sufit RL, Heller SL, Haines JL, Pericak-Vance M, Siddique T. Paraoxonase cluster polymorphisms are associated with sporadic ALS. Neurology. 67: 771-6. PMID 16822964 DOI: 10.1212/01.Wnl.0000227187.52002.88  0.38
2006 Gul A, Hassan MJ, Mahmood S, Chen W, Rahmani S, Naseer MI, Dellefave L, Muhammad N, Rafiq MA, Ansar M, Chishti MS, Ali G, Siddique T, Ahmad W. Genetic studies of autosomal recessive primary microcephaly in 33 Pakistani families: Novel sequence variants in ASPM gene. Neurogenetics. 7: 105-10. PMID 16673149 DOI: 10.1007/s10048-006-0042-4  0.392
2006 Deng HX, Shi Y, Furukawa Y, Zhai H, Fu R, Liu E, Gorrie GH, Khan MS, Hung WY, Bigio EH, Lukas T, Dal Canto MC, O'Halloran TV, Siddique T. Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria. Proceedings of the National Academy of Sciences of the United States of America. 103: 7142-7. PMID 16636275 DOI: 10.1073/Pnas.0602046103  0.468
2006 Furukawa Y, Fu R, Deng HX, Siddique T, O'Halloran TV. Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 7148-53. PMID 16636274 DOI: 10.1073/Pnas.0602048103  0.43
2006 Lukas TJ, Luo WW, Mao H, Cole N, Siddique T. Informatics-assisted protein profiling in a transgenic mouse model of amyotrophic lateral sclerosis. Molecular & Cellular Proteomics : McP. 5: 1233-44. PMID 16571896 DOI: 10.1074/mcp.M500431-MCP200  0.382
2006 Vance C, Al-Chalabi A, Ruddy D, Smith BN, Hu X, Sreedharan J, Siddique T, Schelhaas HJ, Kusters B, Troost D, Baas F, de Jong V, Shaw CE. Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2-21.3. Brain : a Journal of Neurology. 129: 868-76. PMID 16495328 DOI: 10.1093/Brain/Awl030  0.497
2006 Yan J, Siddique N, Slifer S, Bigio E, Mao H, Chen W, Liu E, Shi Y, Khan S, Haines J, Pericak-Vance M, Siddique T. A Major Novel Locus for ALS/FTD on Chromosome 9p21 and its Pathological Correlates: S61.006 Neurology. 67: 186-186. DOI: 10.1212/01.Wnl.0000234887.27166.69  0.547
2005 Li X, Rowland LP, Mitsumoto H, Przedborski S, Bird TD, Schellenberg GD, Peskind E, Johnson N, Siddique T, Mesulam MM, Weintraub S, Mastrianni JA. Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia. Annals of Neurology. 58: 858-64. PMID 16315279 DOI: 10.1002/Ana.20646  0.428
2005 Kuo JJ, Siddique T, Fu R, Heckman CJ. Increased persistent Na(+) current and its effect on excitability in motoneurones cultured from mutant SOD1 mice. The Journal of Physiology. 563: 843-54. PMID 15649979 DOI: 10.1113/Jphysiol.2004.074138  0.431
2005 Faiyaz-Ul-Haque M, Zaidi SH, King LM, Haque S, Patel M, Ahmad M, Siddique T, Ahmad W, Tsui LC, Cohn DH. Fine mapping of the X-linked split-hand/split-foot malformation (SHFM2) locus to a 5.1-Mb region on Xq26.3 and analysis of candidate genes. Clinical Genetics. 67: 93-7. PMID 15617554 DOI: 10.1111/j.1399-0004.2004.00369.x  0.386
2004 Li YJ, Pericak-Vance MA, Haines JL, Siddique N, McKenna-Yasek D, Hung WY, Sapp P, Allen CI, Chen W, Hosler B, Saunders AM, Dellefave LM, Brown RH, Siddique T. Apolipoprotein E is associated with age at onset of amyotrophic lateral sclerosis. Neurogenetics. 5: 209-13. PMID 15657798 DOI: 10.1007/S10048-004-0193-0  0.416
2004 Morris HR, Steele JC, Crook R, Wavrant-De Vrièze F, Onstead-Cardinale L, Gwinn-Hardy K, Wood NW, Farrer M, Lees AJ, McGeer PL, Siddique T, Hardy J, Perez-Tur J. Genome-wide analysis of the parkinsonism-dementia complex of Guam. Archives of Neurology. 61: 1889-97. PMID 15596609 DOI: 10.1001/Archneur.61.12.1889  0.356
2004 Bigio EH, Johnson NA, Rademaker AW, Fung BB, Mesulam MM, Siddique N, Dellefave L, Caliendo J, Freeman S, Siddique T. Neuronal ubiquitinated intranuclear inclusions in familial and non-familial frontotemporal dementia of the motor neuron disease type associated with amyotrophic lateral sclerosis. Journal of Neuropathology and Experimental Neurology. 63: 801-11. PMID 15330335 DOI: 10.1093/Jnen/63.8.801  0.409
2004 Henkel JS, Engelhardt JI, Siklós L, Simpson EP, Kim SH, Pan T, Goodman JC, Siddique T, Beers DR, Appel SH. Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue. Annals of Neurology. 55: 221-35. PMID 14755726 DOI: 10.1002/Ana.10805  0.353
2004 Kuo JJ, Schonewille M, Siddique T, Schults AN, Fu R, Bär PR, Anelli R, Heckman CJ, Kroese AB. Hyperexcitability of cultured spinal motoneurons from presymptomatic ALS mice. Journal of Neurophysiology. 91: 571-5. PMID 14523070 DOI: 10.1152/Jn.00665.2003  0.39
2003 Rezania K, Yan J, Dellefave L, Deng HX, Siddique N, Pascuzzi RT, Siddique T, Roos RP. A rare Cu/Zn superoxide dismutase mutation causing familial amyotrophic lateral sclerosis with variable age of onset, incomplete penetrance and a sensory neuropathy. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group On Motor Neuron Diseases. 4: 162-6. PMID 13129803 DOI: 10.1080/Aml.  0.668
2003 El Euch-Fayache G, Lalani I, Amouri R, Turki I, Ouahchi K, Hung WY, Belal S, Siddique T, Hentati F. Phenotypic features and genetic findings in sacsin-related autosomal recessive ataxia in Tunisia. Archives of Neurology. 60: 982-8. PMID 12873855 DOI: 10.1001/Archneur.60.7.982  0.417
2003 Sapp PC, Hosler BA, McKenna-Yasek D, Chin W, Gann A, Genise H, Gorenstein J, Huang M, Sailer W, Scheffler M, Valesky M, Haines JL, Pericak-Vance M, Siddique T, Horvitz HR, et al. Identification of two novel loci for dominantly inherited familial amyotrophic lateral sclerosis. American Journal of Human Genetics. 73: 397-403. PMID 12858291 DOI: 10.1086/377158  0.538
2003 Ruddy DM, Parton MJ, Al-Chalabi A, Lewis CM, Vance C, Smith BN, Leigh PN, Powell JF, Siddique T, Meyjes EP, Baas F, de Jong V, Shaw CE. Two families with familial amyotrophic lateral sclerosis are linked to a novel locus on chromosome 16q. American Journal of Human Genetics. 73: 390-6. PMID 12840784 DOI: 10.1086/377157  0.458
2003 Aksoy H, Dean G, Elian M, Deng HX, Deng G, Juneja T, Storey E, McKinlay Gardner RJ, Jacob RL, Laing NG, Siddique T. A4T mutation in the SOD1 gene causing familial amyotrophic lateral sclerosis. Neuroepidemiology. 22: 235-8. PMID 12792143 DOI: 10.1159/000070564  0.448
2002 Jonsson PA, Bäckstrand A, Andersen PM, Jacobsson J, Parton M, Shaw C, Swingler R, Shaw PJ, Robberecht W, Ludolph AC, Siddique T, Skvortsova VI, Marklund SL. CuZn-superoxide dismutase in D90A heterozygotes from recessive and dominant ALS pedigrees. Neurobiology of Disease. 10: 327-33. PMID 12270693 DOI: 10.1006/nbdi.2002.0508  0.487
2002 Faiyaz-Ul-Haque M, Ahmad W, Wahab A, Haque S, Azim AC, Zaidi SH, Teebi AS, Ahmad M, Cohn DH, Siddique T, Tsui LC. Frameshift mutation in the cartilage-derived morphogenetic protein 1 (CDMP1) gene and severe acromesomelic chondrodysplasia resembling Grebe-type chondrodysplasia. American Journal of Medical Genetics. 111: 31-7. PMID 12124730 DOI: 10.1002/ajmg.10501  0.392
2001 Cox PR, Siddique T, Zoghbi HY. Genomic organization of Tropomodulins 2 and 4 and unusual intergenic and intraexonic splicing of YL-1 and Tropomodulin 4. Bmc Genomics. 2: 7. PMID 11716785 DOI: 10.1186/1471-2164-2-7  0.375
2001 Yang Y, Hentati A, Deng HX, Dabbagh O, Sasaki T, Hirano M, Hung WY, Ouahchi K, Yan J, Azim AC, Cole N, Gascon G, Yagmour A, Ben-Hamida M, Pericak-Vance M, ... ... Siddique T, et al. The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis. Nature Genetics. 29: 160-5. PMID 11586297 DOI: 10.1038/Ng1001-160  0.482
2000 Gaudette M, Hirano M, Siddique T. Current status of SOD1 mutations in familial amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group On Motor Neuron Diseases. 1: 83-9. PMID 11467054 DOI: 10.1080/14660820050515377  0.487
2000 Deng HX, Siddique T. Transgenic mouse models and human neurodegenerative disorders. Archives of Neurology. 57: 1695-702. PMID 11115235 DOI: 10.1001/Archneur.57.12.1695  0.327
2000 Hentati A, Deng HX, Zhai H, Chen W, Yang Y, Hung WY, Azim AC, Bohlega S, Tandan R, Warner C, Laing NG, Cambi F, Mitsumoto H, Roos RP, Boustany RM, ... ... Siddique T, et al. Novel mutations in spastin gene and absence of correlation with age at onset of symptoms. Neurology. 55: 1388-90. PMID 11087788 DOI: 10.1212/Wnl.55.9.1388  0.656
2000 Hosler BA, Siddique T, Sapp PC, Sailor W, Huang MC, Hossain A, Daube JR, Nance M, Fan C, Kaplan J, Hung WY, McKenna-Yasek D, Haines JL, Pericak-Vance MA, Horvitz HR, et al. Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22. Jama. 284: 1664-9. PMID 11015796 DOI: 10.1001/Jama.284.13.1664  0.459
2000 Hirano M, Hung WY, Cole N, Azim AC, Deng HX, Siddique T. Multiple transcripts of the human Cu,Zn superoxide dismutase gene. Biochemical and Biophysical Research Communications. 276: 52-6. PMID 11006081 DOI: 10.1006/bbrc.2000.3427  0.434
2000 Said Ahmed M, Hung WY, Zu JS, Hockberger P, Siddique T. Increased reactive oxygen species in familial amyotrophic lateral sclerosis with mutations in SOD1. Journal of the Neurological Sciences. 176: 88-94. PMID 10930589 DOI: 10.1016/S0022-510X(00)00317-8  0.457
1999 Cole N, Siddique T. Genetic disorders of motor neurons. Seminars in Neurology. 19: 407-18. PMID 10716663 DOI: 10.1055/s-2008-1040855  0.372
1999 Pérez-Tur J, Buée L, Morris HR, Waring SC, Onstead L, Wavrant-De Vrièze F, Crook R, Buée-Scherrer V, Hof PR, Petersen RC, McGeer PL, Delacourte A, Hutton M, Siddique T, Ahlskog JE, et al. Neurodegenerative diseases of Guam: analysis of TAU. Neurology. 53: 411-3. PMID 10430438 DOI: 10.1212/Wnl.53.2.411  0.403
1998 Siddique T, Pericak-Vance MA, Caliendo J, Hong ST, Hung WY, Kaplan J, McKenna-Yasek D, Rimmler JB, Sapp P, Saunders AM, Scott WK, Siddique N, Haines JL, Brown RH. Lack of association between apolipoprotein E genotype and sporadic amyotrophic lateral sclerosis. Neurogenetics. 1: 213-6. PMID 10737125 DOI: 10.1007/S100480050031  0.431
1998 Hentati A, Ouahchi K, Pericak-Vance MA, Nijhawan D, Ahmad A, Yang Y, Rimmler J, Hung W, Schlotter B, Ahmed A, Ben Hamida M, Hentati F, Siddique T. Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers. Neurogenetics. 2: 55-60. PMID 9933301 DOI: 10.1007/S100480050052  0.364
1998 Al-Chalabi A, Andersen PM, Chioza B, Shaw C, Sham PC, Robberecht W, Matthijs G, Camu W, Marklund SL, Forsgren L, Rouleau G, Laing NG, Hurse PV, Siddique T, Leigh PN, et al. Recessive amyotrophic lateral sclerosis families with the D90A SOD1 mutation share a common founder: evidence for a linked protective factor. Human Molecular Genetics. 7: 2045-50. PMID 9817920 DOI: 10.1093/Hmg/7.13.2045  0.494
1997 Zu JS, Deng HX, Lo TP, Mitsumoto H, Ahmed MS, Hung WY, Cai ZJ, Tainer JA, Siddique T. Exon 5 encoded domain is not required for the toxic function of mutant SOD1 but essential for the dismutase activity: identification and characterization of two new SOD1 mutations associated with familial amyotrophic lateral sclerosis. Neurogenetics. 1: 65-71. PMID 10735277 DOI: 10.1007/S100480050010  0.424
1997 Siddique T, Nijhawan D, Hentati A. Familial amyotrophic lateral sclerosis. Journal of Neural Transmission. Supplementum. 49: 219-33. PMID 9266431 DOI: 10.1007/978-3-7091-6844-8_23  0.527
1997 Isozumi K, DeLong R, Kaplan J, Hung WY, Siddique T. Exclusion of the expansion of CAG/CTG repeats at thirteen loci on chromosome 12 as a candidate genetic mutation in scapuloperoneal spinal muscular atrophy with anticipation. Human Genetics. 99: 701-3. PMID 9187660 DOI: 10.1007/s004390050435  0.421
1997 Kostic V, Gurney ME, Deng HX, Siddique T, Epstein CJ, Przedborski S. Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis. Annals of Neurology. 41: 497-504. PMID 9124807 DOI: 10.1002/Ana.410410413  0.394
1997 Ahmed MS, Afsar S, Hentati A, Ahmad A, Pasha J, Juneja T, Hung WY, Ahmad A, Choudhri A, Saya S, Siddique T. A novel mutation in the sterol 27-hydroxylase gene of a Pakistani family with autosomal recessive cerebrotendinous xanthomatosis. Neurology. 48: 258-60. PMID 9008528 DOI: 10.1212/Wnl.48.1.258  0.44
1997 Juneja T, Pericak-Vance MA, Laing NG, Dave S, Siddique T. Prognosis in familial amyotrophic lateral sclerosis: progression and survival in patients with glu100gly and ala4val mutations in Cu,Zn superoxide dismutase. Neurology. 48: 55-7. PMID 9008494 DOI: 10.1212/Wnl.48.1.55  0.487
1996 Siddique T. ALS: molecular clues to the jigsaw puzzle of neuronal degeneration. Cold Spring Harbor Symposia On Quantitative Biology. 61: 699-708. PMID 9246496 DOI: 10.1101/Sqb.1996.061.01.070  0.367
1996 Siddique T, Deng HX. Genetics of amyotrophic lateral sclerosis. Human Molecular Genetics. 5: 1465-70. PMID 8875253 DOI: 10.1093/Hmg/5.Supplement_1.1465  0.503
1996 Isozumi K, DeLong R, Kaplan J, Deng HX, Iqbal Z, Hung WY, Wilhelmsen KC, Hentati A, Pericak-Vance MA, Siddique T. Linkage of scapuloperoneal spinal muscular atrophy to chromosome 12q24.1-q24.31. Human Molecular Genetics. 5: 1377-82. PMID 8872481 DOI: 10.1093/Hmg/5.9.1377  0.323
1996 Siddique T, Nijhawan D, Hentati A. Molecular genetic basis of familial ALS. Neurology. 47: S27-34; discussion S. PMID 8858048 DOI: 10.1212/Wnl.47.4_Suppl_2.27S  0.535
1996 Shibata N, Hirano A, Kobayashi M, Siddique T, Deng HX, Hung WY, Kato T, Asayama K. Intense superoxide dismutase-1 immunoreactivity in intracytoplasmic hyaline inclusions of familial amyotrophic lateral sclerosis with posterior column involvement. Journal of Neuropathology and Experimental Neurology. 55: 481-90. PMID 8786408 DOI: 10.1097/00005072-199604000-00011  0.412
1996 Fink JK, Heiman-Patterson T, Bird T, Cambi F, Dubé MP, Figlewicz DA, Fink JK, Haines JL, Heiman-Patterson T, Hentati A, Pericak-Vance MA, Raskind W, Rouleau GA, Siddique T. Hereditary spastic paraplegia: advances in genetic research. Hereditary Spastic Paraplegia Working group. Neurology. 46: 1507-14. PMID 8649538 DOI: 10.1212/Wnl.46.6.1507  0.378
1996 Hentati A, Deng HX, Hung WY, Nayer M, Ahmed MS, He X, Tim R, Stumpf DA, Siddique T, Ahmed. Human alpha-tocopherol transfer protein: gene structure and mutations in familial vitamin E deficiency. Annals of Neurology. 39: 295-300. PMID 8602747 DOI: 10.1002/Ana.410390305  0.421
1995 Siddique T, Hentati A. Familial amyotrophic lateral sclerosis. Clinical Neuroscience (New York, N.Y.). 3: 338-47. PMID 9021255  0.437
1995 Gascon GG, Chavis P, Yaghmour A, Stigsby B, Shums A, Ozand P, Siddique T. Familial childhood primary lateral sclerosis with associated gaze paresis. Neuropediatrics. 26: 313-9. PMID 8719747 DOI: 10.1055/s-2007-979781  0.319
1995 Deng HX, Tainer JA, Mitsumoto H, Ohnishi A, He X, Hung WY, Zhao Y, Juneja T, Hentati A, Siddique T. Two novel SOD1 mutations in patients with familial amyotrophic lateral sclerosis. Human Molecular Genetics. 4: 1113-6. PMID 7655471 DOI: 10.1093/Hmg/4.6.1113  0.46
1995 Själander A, Beckman G, Deng HX, Iqbal Z, Tainer JA, Siddique T. The D90A mutation results in a polymorphism of Cu,Zn superoxide dismutase that is prevalent in northern Sweden and Finland. Human Molecular Genetics. 4: 1105-8. PMID 7655469 DOI: 10.1093/Hmg/4.6.1105  0.311
1995 Roos RR, Siddique T, Tainer JA. Summary of `Superoxide Dismutase (SOD) and Free Radicals in Amyotrophic Lateral Sclerosis and Neurodegeneration' conference Neurology. 45: 1779-1780. DOI: 10.1212/WNL.45.9.1779  0.472
1994 Mérette C, Brzustowicz LM, Daniels RJ, Davies KE, Gilliam TC, Melki J, Munnich A, Pericak-Vance MA, Siddique T, Voosen B. An investigation of genetic heterogeneity and linkage disequilibrium in 161 families with spinal muscular atrophy. Genomics. 21: 27-33. PMID 8088801 DOI: 10.1006/Geno.1994.1220  0.353
1993 Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O'Regan JP, Deng HX. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 362: 59-62. PMID 8446170 DOI: 10.1038/362059a0  0.394
1993 Deng HX, Hentati A, Tainer JA, Iqbal Z, Cayabyab A, Hung WY, Getzoff ED, Hu P, Herzfeldt B, Roos RP, Warner C, Deng G, Soriano E, Smyth C, Parge HE, ... ... Siddique T, et al. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase Science. 261: 1047-1051. PMID 8351519 DOI: 10.1126/Science.8351519  0.685
1992 Appelbaum JS, Roos RP, Salazar-Grueso EF, Buchman A, Iannaccone S, Glantz R, Siddique T, Maselli R. Intrafamilial heterogeneity in hereditary motor neuron disease. Neurology. 42: 1488-92. PMID 1641141 DOI: 10.1212/Wnl.42.8.1488  0.637
1992 DeLong R, Siddique T. A large New England kindred with autosomal dominant neurogenic scapuloperoneal amyotrophy with unique features. Archives of Neurology. 49: 905-8. PMID 1520078 DOI: 10.1001/Archneur.1992.00530330027010  0.337
1991 Siddique T, Figlewicz DA, Pericak-Vance MA, Haines JL, Rouleau G, Jeffers AJ, Sapp P, Hung WY, Bebout J, McKenna-Yasek D. Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity. The New England Journal of Medicine. 324: 1381-4. PMID 2020294 DOI: 10.1056/Nejm199105163242001  0.437
1991 Eldridge R, Alberstone C, Meyer MA, Siddique T, Brown RH. Genetic basis of familial amyotrophic lateral sclerosis The New England Journal of Medicine. 325: 1382-1383. PMID 1922244 DOI: 10.1056/Nejm199111073251915  0.383
1991 Alberts MJ, Kandt RS, Pericak-Vance MA, Bebout J, Speer MC, Siddique TS, Yamaoka L, Hung WY, Gaskell PC, Roses AD. MspI RFLP for microtubule associated protein-2 (MAP2). Nucleic Acids Research. 19: 960. PMID 1708129 DOI: 10.1093/Nar/19.4.960  0.357
1989 Sarfarazi M, Upadhyaya M, Padberg G, Pericak-Vance M, Siddique T, Lucotte G, Lunt P. An exclusion map for facioscapulohumeral (Landouzy-Déjérine) disease. Journal of Medical Genetics. 26: 481-4. PMID 2769720 DOI: 10.1136/Jmg.26.8.481  0.309
1989 Siddique T, Pericak-Vance MA, Brooks BR, Roos RP, Hung WY, Antel JP, Munsat TL, Phillips K, Warner K, Speer M. Linkage analysis in familial amyotrophic lateral sclerosis. Neurology. 39: 919-25. PMID 2739919 DOI: 10.1212/Wnl.39.7.919  0.621
1989 Laing NG, Siddique T, Bartlett R, Yamaoka LH, Hung WY, Pericak-Vance MA, Roses AD. Duchenne muscular dystrophy: detection of deletion carriers by spectrophotometric densitometry. Clinical Genetics. 35: 393-8. PMID 2736788 DOI: 10.1111/J.1399-0004.1989.Tb02963.X  0.513
1989 Siddique T, Roper H, Pericak-Vance MA, Shaw J, Warner KL, Hung WY, Phillips KL, Lunt P, Cumming WJ, Roses AD. Linkage analysis in the spinal muscular atrophy type of facioscapulohumeral disease. Journal of Medical Genetics. 26: 487-9. PMID 2570155 DOI: 10.1136/Jmg.26.8.487  0.535
1989 Siddique T, Phillips K, Betz H, Grenningloh G, Warner K, Hung WY, Laing N, Roses AD. RFLPs of the gene for the human glycine receptor on the X-chromosome. Nucleic Acids Research. 17: 1785. PMID 2564191 DOI: 10.1093/Nar/17.4.1785  0.432
1988 Bartlett RJ, Pericak-Vance MA, Koh J, Yamaoka LH, Chen JC, Hung WY, Speer MC, Wapenaar MC, Van Ommen GJB, Bakker E, Pearson PL, Kandt RS, Siddique T, Gilbert JR, Lee JE, et al. Duchenne muscular dystrophy: High frequency of deletions Neurology. 38: 1-4. PMID 3275902 DOI: 10.1212/Wnl.38.1.1  0.493
1988 Siddique T, Bartlett R, Pericak-Vance M, Yamaoka L, Koh J, Chen J, Hung WY, Kandt R, Roses AD. Update on the molecular genetics of Duchenne muscular dystrophy. Australian Paediatric Journal. 24: 9-14. PMID 3060079  0.438
1988 Walker AP, Bartlett RJ, Laing NG, Siddique T, Yamaoka LH, Chen JC, Hung WY, Roses AD. RFLP for Duchenne muscular dystrophy cDNA clone 30-2. Nucleic Acids Research. 16: 9072. PMID 2902573 DOI: 10.1093/Nar/16.18.9072  0.437
1988 Laing NG, Siddique T, Bartlett RJ, Yamaoka LH, Chen JC, Walker AP, Hung WY, Roses AD. RFLP for Duchenne muscular dystrophy cDNA clone 44-1. Nucleic Acids Research. 16: 7209. PMID 2900496 DOI: 10.1093/Nar/16.14.7209  0.437
1988 Siddique T, McKinney R, Hung WY, Bartlett RJ, Bruns G, Mohandas TK, Ropers HH, Wilfert C, Roses AD. The poliovirus sensitivity (PVS) gene is on chromosome 19q12----q13.2. Genomics. 3: 156-60. PMID 2852161 DOI: 10.1016/0888-7543(88)90147-4  0.48
1987 Vance JM, Pericak-Vance MA, Bowman MH, Payne CS, Fredane L, Siddique T, Roses AD, Massey EW. Chorea-acanthocytosis: a report of three new families and implications for genetic counselling. American Journal of Medical Genetics. 28: 403-10. PMID 3322006 DOI: 10.1002/Ajmg.1320280219  0.52
1986 Roses AD, Pericak-Vance MA, Yamaoka LH, Herbstreith MH, Bartlett RJ, Siddique T, Hung WY, Ross DA, Mohandas TK, Bruns G. A new tightly linked DNA probe for myotonic dystrophy. Neurology. 36: 1146. PMID 3736889 DOI: 10.1212/Wnl.36.8.1146  0.417
1985 Askanas V, Engel WK, Kwan HH, Reddy NB, Husainy T, Carlo J, Siddique T, Schwartzman RJ, Hanna CJ. Autosomal dominant syndrome of lipid neuromyopathy with normal carnitine: successful treatment with long-chain fatty-acid-free diet. Neurology. 35: 66-72. PMID 3966003 DOI: 10.1212/WNL.35.1.66  0.471
1983 Engel WK, Siddique T, Nicoloff JT. Effect on weakness and spasticity in amyotrophic lateral sclerosis of thyrotropin-releasing hormone. Lancet. 2: 73-5. PMID 6134961 DOI: 10.1016/S0140-6736(83)90060-0  0.55
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