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P. Hande Ozdinler - Publications

Affiliations: 
Northwestern University, Evanston, IL 
Area:
Cell Biology, Molecular Neuroscience, Neurobiology of Disease, Systems Neuroscience
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Elmansy MF, Reidl CT, Rahaman M, Özdinler PH, Silverman RB. Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis. Medicinal Research Reviews. PMID 37243319 DOI: 10.1002/med.21974  0.381
2023 Gautam M, Genç B, Helmold B, Ahrens A, Kuka J, Makrecka-Kuka M, Günay A, Koçak N, Aguilar-Wickings IR, Keefe D, Zheng G, Swaminathan S, Redmon M, Zariwala HA, Özdinler PH. SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function. Neurobiology of Disease. 178: 106022. PMID 36716828 DOI: 10.1016/j.nbd.2023.106022  0.363
2022 Gautam M, Gunay A, Chandel NS, Ozdinler PH. Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD balance as a therapeutic strategy. Scientific Reports. 12: 4287. PMID 35277554 DOI: 10.1038/s41598-022-08068-5  0.413
2021 Gozutok O, Helmold BR, Ozdinler PH. Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS. Brain Sciences. 11. PMID 33947096 DOI: 10.3390/brainsci11050578  0.356
2021 Genç B, Gautam M, Gözütok Ö, Dervishi I, Sanchez S, Goshu GM, Koçak N, Xie E, Silverman RB, Özdinler PH. Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP-43 pathology. Clinical and Translational Medicine. 11: e336. PMID 33634973 DOI: 10.1002/ctm2.336  0.486
2020 Ozdinler PH, Gautam M, Gozutok O, Konrad C, Manfredi G, Area Gomez E, Mitsumoto H, Erb ML, Tian Z, Haase G. Better understanding the neurobiology of primary lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 21: 35-46. PMID 33602014 DOI: 10.1080/21678421.2020.1837175  0.424
2020 Gunay A, Shin HH, Gozutok O, Gautam M, Ozdinler PH. Importance of lipids for upper motor neuron health and disease. Seminars in Cell & Developmental Biology. PMID 33323321 DOI: 10.1016/j.semcdb.2020.11.004  0.39
2020 Jara JH, Sheets PL, Nigro MJ, Perić M, Brooks C, Heller DB, Martina M, Andjus PR, Ozdinler PH. The Electrophysiological Determinants of Corticospinal Motor Neuron Vulnerability in ALS. Frontiers in Molecular Neuroscience. 13: 73. PMID 32508590 DOI: 10.3389/Fnmol.2020.00073  0.714
2020 Genc B, Gozutok O, Kocak N, Ozdinler PH. The Timing and Extent of Motor Neuron Vulnerability in ALS Correlates with Accumulation of Misfolded SOD1 Protein in the Cortex and in the Spinal Cord. Cells. 9. PMID 32098365 DOI: 10.3390/cells9020502  0.629
2019 Gautam M, Xie EF, Kocak N, Ozdinler PH. Mitoautophagy: A Unique Self-Destructive Path Mitochondria of Upper Motor Neurons With TDP-43 Pathology Take, Very Early in ALS. Frontiers in Cellular Neuroscience. 13: 489. PMID 31787882 DOI: 10.3389/fncel.2019.00489  0.388
2019 Jara JH, Gautam M, Kocak N, Xie EF, Mao Q, Bigio EH, Özdinler PH. MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology. Journal of Neuroinflammation. 16: 196. PMID 31666087 DOI: 10.1186/S12974-019-1589-Y  0.482
2019 Genc B, Gozutok O, Ozdinler PH. Complexity of Generating Mouse Models to Study the Upper Motor Neurons: Let Us Shift Focus from Mice to Neurons. International Journal of Molecular Sciences. 20. PMID 31394733 DOI: 10.3390/ijms20163848  0.632
2018 Dervishi I, Gozutok O, Murnan K, Gautam M, Heller D, Bigio E, Ozdinler PH. Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS. Scientific Reports. 8: 14732. PMID 30283000 DOI: 10.1038/s41598-018-32902-4  0.371
2018 Dervishi I, Ozdinler PH. Incorporating upper motor neuron health in ALS drug discovery. Drug Discovery Today. PMID 29331501 DOI: 10.1016/j.drudis.2018.01.027  0.538
2017 Jara JH, Genç B, Stanford MJ, Pytel P, Roos RP, Weintraub S, Mesulam MM, Bigio EH, Miller RJ, Özdinler PH. Evidence for an early innate immune response in the motor cortex of ALS. Journal of Neuroinflammation. 14: 129. PMID 28651542 DOI: 10.1186/S12974-017-0896-4  0.378
2017 Genç B, Jara JH, Lagrimas AK, Pytel P, Roos RP, Mesulam MM, Geula C, Bigio EH, Özdinler PH. Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS. Scientific Reports. 7: 41765. PMID 28165465 DOI: 10.1038/Srep41765  0.43
2016 Geevasinga N, Menon P, Özdinler PH, Kiernan MC, Vucic S. Pathophysiological and diagnostic implications of cortical dysfunction in ALS. Nature Reviews. Neurology. PMID 27658852 DOI: 10.1038/nrneurol.2016.140  0.525
2016 Genç B, Jara JH, Schultz MC, Manuel M, Stanford MJ, Gautam M, Klessner JL, Sekerkova G, Heller DB, Cox GA, Heckman CJ, DiDonato CJ, Özdinler PH. Absence of UCHL 1 function leads to selective motor neuropathy. Annals of Clinical and Translational Neurology. 3: 331-45. PMID 27231703 DOI: 10.1002/Acn3.298  0.571
2016 Gautam M, Jara JH, Sekerkova G, Yasvoina MV, Martina M, Özdinler PH. Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms. Human Molecular Genetics. PMID 26755825 DOI: 10.1093/Hmg/Ddv631  0.611
2015 Jara JH, Stanford MJ, Zhu Y, Tu M, Hauswirth WW, Bohn MC, DeVries SH, Özdinler PH. Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex. Gene Therapy. PMID 26704722 DOI: 10.1038/Gt.2015.112  0.578
2015 Genç B, Lagrimas AK, Kuru P, Hess R, Tu MW, Menichella DM, Miller RJ, Paller AS, Özdinler PH. Visualization of Sensory Neurons and Their Projections in an Upper Motor Neuron Reporter Line. Plos One. 10: e0132815. PMID 26222784 DOI: 10.1371/journal.pone.0132815  0.607
2015 Jara JH, Genç B, Cox GA, Bohn MC, Roos RP, Macklis JD, Ulup?nar E, Özdinler PH. Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function. Cerebral Cortex (New York, N.Y. : 1991). PMID 25596590 DOI: 10.1093/Cercor/Bhu318  0.717
2015 Joyce PI, Mcgoldrick P, Saccon RA, Weber W, Fratta P, West SJ, Zhu N, Carter S, Phatak V, Stewart M, Simon M, Kumar S, Heise I, Bros-Facer V, Dick J, ... ... Ozdinler PH, et al. A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity. Human Molecular Genetics. 24: 1883-97. PMID 25468678 DOI: 10.1093/Hmg/Ddu605  0.464
2014 Ozdinler PH, Silverman RB. Treatment of amyotrophic lateral sclerosis: lessons learned from many failures. Acs Medicinal Chemistry Letters. 5: 1179-81. PMID 25408825 DOI: 10.1021/Ml500404B  0.483
2014 Jara JH, Genç B, Klessner JL, Ozdinler PH. Retrograde labeling, transduction, and genetic targeting allow cellular analysis of corticospinal motor neurons: implications in health and disease. Frontiers in Neuroanatomy. 8: 16. PMID 24723858 DOI: 10.3389/Fnana.2014.00016  0.497
2012 Tharin S, Kothapalli CR, Ozdinler PH, Pasquina L, Chung S, Varner J, DeValence S, Kamm R, Macklis JD. A microfluidic device to investigate axon targeting by limited numbers of purified cortical projection neuron subtypes. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 1398-405. PMID 23034677 DOI: 10.1039/C2Ib20019H  0.703
2012 Srivastava DP, Woolfrey KM, Jones KA, Anderson CT, Smith KR, Russell TA, Lee H, Yasvoina MV, Wokosin DL, Ozdinler PH, Shepherd GM, Penzes P. An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice. Plos Biology. 10: e1001350. PMID 22745599 DOI: 10.1371/Journal.Pbio.1001350  0.431
2012 Jara JH, Villa SR, Khan NA, Bohn MC, Ozdinler PH. AAV2 mediated retrograde transduction of corticospinal motor neurons reveals initial and selective apical dendrite degeneration in ALS. Neurobiology of Disease. 47: 174-83. PMID 22521461 DOI: 10.1016/J.Nbd.2012.03.036  0.628
2011 Ozdinler PH, Benn S, Yamamoto TH, Güzel M, Brown RH, Macklis JD. Corticospinal motor neurons and related subcerebral projection neurons undergo early and specific neurodegeneration in hSOD1G⁹³A transgenic ALS mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4166-77. PMID 21411657 DOI: 10.1523/JNEUROSCI.4184-10.2011  0.73
2006 Ozdinler PH, Macklis JD. IGF-I specifically enhances axon outgrowth of corticospinal motor neurons. Nature Neuroscience. 9: 1371-81. PMID 17057708 DOI: 10.1038/nn1789  0.724
2006 Steele AD, Emsley JG, Ozdinler PH, Lindquist S, Macklis JD. Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. Proceedings of the National Academy of Sciences of the United States of America. 103: 3416-21. PMID 16492732 DOI: 10.1073/Pnas.0511290103  0.66
2005 Ozdinler PH, Ulupinar E, Erzurumlu RS. Dose and age-dependent axonal responses of embryonic trigeminal neurons to localized NGF via p75NTR receptor. Journal of Neurobiology. 62: 189-206. PMID 15459897 DOI: 10.1002/Neu.20074  0.439
2004 Genç B, Ozdinler PH, Mendoza AE, Erzurumlu RS. A chemoattractant role for NT-3 in proprioceptive axon guidance. Plos Biology. 2: e403. PMID 15550985 DOI: 10.1371/Journal.Pbio.0020403  0.45
2004 Ozdinler PH, Ulupinar E, Erzurumlu RS. Local neurotrophin effects on central trigeminal axon growth patterns. Brain Research. Developmental Brain Research. 151: 55-66. PMID 15246692 DOI: 10.1016/J.Devbrainres.2004.03.017  0.376
2002 Ozdinler PH, Erzurumlu RS. Slit2, a branching-arborization factor for sensory axons in the Mammalian CNS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4540-9. PMID 12040061 DOI: 10.1523/Jneurosci.22-11-04540.2002  0.407
2001 Ozdinler PH, Erzurumlu RS. Regulation of neurotrophin-induced axonal responses via Rho GTPases. The Journal of Comparative Neurology. 438: 377-87. PMID 11559894 DOI: 10.1002/cne.1321  0.317
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