Colin G. Nichols - Publications

Affiliations: 
Washington University School of Medicine, St. Louis, MO, United States 
Area:
ion channels

305 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 D'Avanzo N, Miles AJ, Powl AM, Nichols CG, Wallace BA, O'Reilly AO. The T1-tetramerization Domain of Kv1.2 Rescues Expression and Preserves Function of a Truncated NaChBac Sodium Channel. Febs Letters. PMID 35015304 DOI: 10.1002/1873-3468.14279  0.788
2021 Singareddy SS, Roessler HI, McClenaghan C, Ikle JM, Tryon RC, van Haaften G, Nichols CG. ATP-sensitive potassium channels in zebrafish cardiac and vascular smooth muscle. The Journal of Physiology. PMID 34820842 DOI: 10.1113/JP282157  0.578
2021 Kim HJ, Li M, Nichols CG, Davis MJ. Large-conductance calcium-activated K channels, rather than K channels, mediate the inhibitory effects of nitric oxide on mouse lymphatic pumping. British Journal of Pharmacology. PMID 34213021 DOI: 10.1111/bph.15602  0.489
2021 Matamoros M, Nichols CG. Pore-forming transmembrane domains control ion selectivity and selectivity filter conformation in the KirBac1.1 potassium channel. The Journal of General Physiology. 153. PMID 33779689 DOI: 10.1085/jgp.202012683  0.45
2021 Zhang H, Hanson AM, Scherf de Almeida TU, Emfinger CH, McClenaghan C, Harter T, Yan Z, Cooper PE, Brown GS, Arakel EC, Mecham RP, Kovacs A, Halabi CM, Schwappach B, Remedi MS, ... Nichols CG, et al. Complex consequences of Cantu Syndrome SUR2 variant R1154Q in genetically modified mice. Jci Insight. PMID 33529173 DOI: 10.1172/jci.insight.145934  0.769
2020 Scala R, Maqoud F, Zizzo N, Mele A, Camerino GM, Zito FA, Ranieri G, McClenaghan C, Harter TM, Nichols CG, Tricarico D. Pathophysiological Consequences of KATP Channel Overactivity and Pharmacological Response to Glibenclamide in Skeletal Muscle of a Murine Model of Cantù Syndrome. Frontiers in Pharmacology. 11: 604885. PMID 33329006 DOI: 10.3389/fphar.2020.604885  0.345
2020 York NW, Parker H, Xie Z, Tyus D, Waheed MA, Yan Z, Grange DK, Remedi MS, England SK, Hu H, Nichols CG. Kir6.1- and SUR2-dependent KATP over-activity disrupts intestinal motility in murine models of Cantu Syndrome. Jci Insight. PMID 33170808 DOI: 10.1172/jci.insight.141443  0.446
2020 McClenaghan C, Huang Y, Matkovich SJ, Kovacs A, Weinheimer CJ, Perez R, Broekelmann TJ, Harter TM, Lee JM, Remedi MS, Nichols CG. The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome. Function (Oxford, England). 1: zqaa004. PMID 32865539 DOI: 10.1093/function/zqaa004  0.33
2020 Davis MJ, Kim HJ, Zawieja SD, Castorena-Gonzalez JA, Gui P, Li M, Saunders BT, Zinselmeyer BH, Randolph GJ, Remedi MS, Nichols CG. Kir6.1-dependent K channels in lymphatic smooth muscle and vessel dysfunction in mice with Kir6.1 gain-of-function. The Journal of Physiology. PMID 32372450 DOI: 10.1113/JP279612  0.564
2020 IKLE J, SINGAREDDY SS, TRYON RC, YORK N, YIN L, CHEN W, NICHOLS C. 2070-P: KCNJ11 (Kir6.2) Gain-of-Function Mutation in Zebrafish Leads to Transient Neonatal Diabetes Diabetes. 69: 2070-P. DOI: 10.2337/Db20-2070-P  0.416
2020 Matamoros M, Joo Lee S, Wang S, Nichols CG. Molecular Mechanisms of Ion Selectivity in Potassium Channels Biophysical Journal. 118: 363a. DOI: 10.1016/j.bpj.2019.11.2087  0.503
2020 Singareddy SS, Roessler HI, McClenaghan C, Tryon RC, van Haaften G, Nichols CG. KATP Channels in Zebrafish Cardiovascular System: A Model to Study Cantú Syndrome Biophysical Journal. 118: 259a. DOI: 10.1016/J.Bpj.2019.11.1503  0.524
2020 Lee SJ, Chen Z, Budelier M, Krishnan K, Covey DF, Evers AS, Nichols CG. The Molecular Mechanisms of Cholesterol Regulation of Kir Channels Revealed by Direct and Quantitative Approaches Biophysical Journal. 118: 191a. DOI: 10.1016/J.Bpj.2019.11.1157  0.522
2019 Grange DK, Roessler HI, McClenaghan C, Duran K, Shields K, Remedi MS, Knoers NVAM, Lee JM, Kirk EP, Scurr I, Smithson SF, Singh GK, van Haelst MM, Nichols CG, van Haaften G. Cantú syndrome: Findings from 74 patients in the International Cantú Syndrome Registry. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. 181: 658-681. PMID 31828977 DOI: 10.1002/Ajmg.C.31753  0.341
2019 McClenaghan C, Huang Y, Yan Z, Harter T, Halabi CM, Chalk R, Kovacs A, van Haaften G, Remedi MS, Nichols CG. Glibenclamide reverses cardiovascular abnormalities of Cantu Syndrome driven by KATP channel overactivity. The Journal of Clinical Investigation. PMID 31821173 DOI: 10.1172/Jci130571  0.549
2019 Zangerl-Plessl EM, Lee SJ, Maksaev G, Bernsteiner H, Ren F, Yuan P, Stary-Weinzinger A, Nichols CG. Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels. The Journal of General Physiology. PMID 31744859 DOI: 10.1085/jgp.201912422  0.543
2019 Smeland MF, McClenaghan C, Roessler HI, Savelberg S, Hansen GÅM, Hjellnes H, Arntzen KA, Müller KI, Dybesland AR, Harter T, Sala-Rabanal M, Emfinger CH, Huang Y, Singareddy SS, Gunn J, ... Nichols CG, et al. ABCC9-related Intellectual disability Myopathy Syndrome is a K channelopathy with loss-of-function mutations in ABCC9. Nature Communications. 10: 4457. PMID 31575858 DOI: 10.1038/S41467-019-12428-7  0.382
2019 Ma A, Gurnasinghani S, Kirk EP, McClenaghan C, Singh GK, Grange DK, Pandit C, Zhou Y, Roscioli T, Elakis G, Buckley M, Mehta B, Roberts P, Mervis J, Biggin A, ... Nichols CG, et al. Glibenclamide treatment in a Cantú syndrome patient with a pathogenic ABCC9 gain-of-function variant: Initial experience. American Journal of Medical Genetics. Part A. PMID 31175705 DOI: 10.1002/Ajmg.A.61200  0.365
2019 McClenaghan C, Woo KV, Nichols CG. Pulmonary Hypertension and ATP-Sensitive Potassium Channels. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA11912. PMID 31132951 DOI: 10.1161/Hypertensionaha.119.12992  0.515
2019 Huang Y, Hu D, Huang C, Nichols CG. Genetic Discovery of ATP-Sensitive K Channels in Cardiovascular Diseases. Circulation. Arrhythmia and Electrophysiology. 12: e007322. PMID 31030551 DOI: 10.1161/CIRCEP.119.007322  0.485
2019 Wang S, Lee SJ, Maksaev G, Fang X, Zuo C, Nichols CG. Potassium channel selectivity filter dynamics revealed by single-molecule FRET. Nature Chemical Biology. PMID 30833778 DOI: 10.1038/s41589-019-0240-7  0.366
2019 Moiseenkova-Bell VY, Nichols CG, Agar J. Decision letter: Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM Elife. DOI: 10.7554/Elife.46417.040  0.528
2019 Adelman JP, Clapham DE, Hibino H, Inanobe A, Jan LY, Karschin A, Kubo Y, Kurachi Y, Lazdunski M, Miki T, Nichols CG, Palmer LG, Pearson WL, Sackin H, Seino S, et al. Inwardly rectifying potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f74/2019.4  0.542
2019 McClenaghan C, Huang Y, Halabi C, Harter T, Mecham RP, Remedi MS, Nichols CG. The Mechanism of Cardiovascular Pathophysiology in Cantu Syndrome and Response to Glibenclamide in Novel KATP Channel Mutant Mouse Models Biophysical Journal. 116: 31a. DOI: 10.1016/J.Bpj.2018.11.209  0.51
2018 Nichols CG, Lee SJ. Polyamines and potassium channels: A twenty five year romance. The Journal of Biological Chemistry. PMID 30333230 DOI: 10.1074/jbc.TM118.003344  0.554
2018 Huang Y, McClenaghan C, Harter TM, Hinman K, Halabi CM, Matkovich SJ, Zhang H, Brown GS, Mecham RP, England SK, Kovacs A, Remedi MS, Nichols CG. Cardiovascular consequences of KATP overactivity in Cantu syndrome. Jci Insight. 3. PMID 30089727 DOI: 10.1172/Jci.Insight.121153  0.308
2018 Makepeace CM, Suarez-Pierre A, Kanter EM, Schuessler RB, Nichols CG, Lawton JS. Superior diastolic function with K channel opener diazoxide in a novel mouse Langendorff model. The Journal of Surgical Research. 227: 186-193. PMID 29804852 DOI: 10.1016/j.jss.2018.02.024  0.556
2018 Deng Z, Paknejad N, Maksaev G, Sala-Rabanal M, Nichols CG, Hite RK, Yuan P. Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms. Nature Structural & Molecular Biology. PMID 29483651 DOI: 10.1038/S41594-018-0037-5  0.554
2018 Wang S, Brettmann JB, Nichols CG. Studying Structural Dynamics of Potassium Channels by Single-Molecule FRET. Methods in Molecular Biology (Clifton, N.J.). 1684: 163-180. PMID 29058191 DOI: 10.1007/978-1-4939-7362-0_13  0.597
2018 McClenaghan C, Huang Y, Harter T, Brown GS, Hinman K, Halabi C, Matkovich S, Mecham RP, Weinheimer CJ, Kovacs A, England S, Remedi MS, Nichols CG. Abstract 011: Cardiovascular Consequences of Cantu Syndrome and Response to Glibenclamide Treatment in Two Novel KATP Channel Mutant Mouse Models Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/Atvb.38.Suppl_1.011  0.493
2017 McClenaghan C, Hanson A, Sala-Rabanal M, Roessler HI, Josifova D, Grange DK, van Haaften G, Nichols CG. Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms. The Journal of Biological Chemistry. PMID 29275331 DOI: 10.1074/Jbc.Ra117.000351  0.461
2017 Cooper PE, McClenaghan C, Chen X, Stary-Weinzinger A, Nichols CG. Conserved functional consequences of disease-associated mutations in the slide-helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel. The Journal of Biological Chemistry. PMID 28842488 DOI: 10.1074/Jbc.M117.804971  0.804
2017 Qiao Y, Lipovsky C, Hicks S, Bhatnagar S, Li G, Khandekar A, Guzy R, Woo KV, Nichols CG, Efimov IR, Rentschler S. Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice. Circulation Research. PMID 28674041 DOI: 10.1161/Circresaha.116.310396  0.364
2017 Wang S, Borschel WF, Heyman S, Hsu P, Nichols CG. Conformational changes at cytoplasmic inter-subunit interactions control Kir channel gating. The Journal of Biological Chemistry. PMID 28446610 DOI: 10.1074/jbc.M117.785154  0.854
2017 Sala-Rabanal M, Yurtsever Z, Berry KN, Nichols CG, Brett TJ. Modulation of TMEM16A Channel Activity by the Von Willebrand Factor Type A (VWA) domain of the Calcium-Activated Chloride Channel Regulator 1 (CLCA1). The Journal of Biological Chemistry. PMID 28420732 DOI: 10.1074/Jbc.M117.788232  0.503
2017 Borschel WF, Wang S, Lee S, Nichols CG. Control of Kir channel gating by cytoplasmic domain interface interactions. The Journal of General Physiology. PMID 28389584 DOI: 10.1085/jgp.201611719  0.866
2017 Emfinger CH, Welscher A, Yan Z, Wang Y, Conway H, Moss JB, Moss LG, Remedi MS, Nichols CG. Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells. Royal Society Open Science. 4: 160808. PMID 28386438 DOI: 10.1098/rsos.160808  0.566
2017 Brettmann J, Lee S, Wang S, Nichols CG. Characterization of Structural Changes via Lipid Regulation of KIR2.1 in a Lipid Environment Biophysical Journal. 112: 550a-551a. DOI: 10.1016/J.BPJ.2016.11.2972  0.515
2017 Wang S, Nichols CG. Structural Dynamics of the Potassium Channel Selectivity Filter Revealed by Single-Molecule FRET Biophysical Journal. 112: 247a-248a. DOI: 10.1016/J.BPJ.2016.11.1353  0.464
2016 Remedi MS, Friedman JB, Nichols CG. Diabetes induced by gain-of-function mutations in the Kir6.1 subunit of the KATP channel. The Journal of General Physiology. PMID 27956473 DOI: 10.1085/jgp.201611653  0.468
2016 Jimah JR, Salinas ND, Sala-Rabanal M, Jones NG, Sibley LD, Nichols CG, Schlesinger PH, Tolia NH. Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption. Elife. 5. PMID 27906127 DOI: 10.7554/Elife.20621  0.304
2016 Lee SJ, Ren F, Zangerl-Plessl EM, Heyman S, Stary-Weinzinger A, Yuan P, Nichols CG. Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids. The Journal of General Physiology. PMID 27527100 DOI: 10.1085/jgp.201611616  0.426
2016 Nichols CG. Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection. Cardiac Electrophysiology Clinics. 8: 323-35. PMID 27261824 DOI: 10.1016/j.ccep.2016.01.005  0.603
2016 Levin MD, Singh GK, Zhang HX, Uchida K, Kozel BA, Stein PK, Kovacs A, Westenbroek RE, Catterall WA, Grange DK, Nichols CG. KATP channel gain-of-function leads to increased myocardial L-type Ca2+ current and contractility in Cantu syndrome. Proceedings of the National Academy of Sciences of the United States of America. PMID 27247394 DOI: 10.1073/Pnas.1606465113  0.492
2016 Kharade SV, Nichols C, Denton JS. The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics. Future Medicinal Chemistry. PMID 27161588 DOI: 10.4155/Fmc-2016-0005  0.496
2016 Méndez-González MP, Kucheryavykh YV, Zayas-Santiago A, Vélez-Carrasco W, Maldonado-Martínez G, Cubano LA, Nichols CG, Skatchkov SN, Eaton MJ. Novel KCNJ10 variations compromise function of inwardly rectifying potassium channel 4.1. The Journal of Biological Chemistry. PMID 26867573 DOI: 10.1074/jbc.M115.679910  0.575
2016 Henn MC, Janjua MB, Zhang H, Kanter EM, Makepeace CM, Schuessler RB, Nichols CG, Lawton JS. Increased tolerance to stress in cardiac expressed gain-of-function of adenosine triphosphate–sensitive potassium channel subunit Kir6.1 Journal of Surgical Research. 206: 460-465. DOI: 10.1016/j.jss.2016.08.043  0.326
2016 Sala-Rabanal M, Yurtsever Z, Nichols CG, Brett TJ. Secreted Human CLCA1 Activates Calcium-Dependent Chloride Currents through Direct Binding of Its VWA Domain with an Extracellular Loop of TMEM16A/Anoctamin 1 Biophysical Journal. 110: 606a. DOI: 10.1016/J.Bpj.2015.11.3235  0.414
2016 Remedi MS, Nichols CG. KATP Channels in the Pancreas: Hyperinsulinism and Diabetes. Hyperinsulinism and Diabetes Ion Channels in Health and Disease. 199-221. DOI: 10.1016/B978-0-12-802002-9.00008-X  0.536
2015 Wang S, Vafabakhsh R, Borschel WF, Ha T, Nichols CG. Structural dynamics of potassium-channel gating revealed by single-molecule FRET. Nature Structural & Molecular Biology. PMID 26641713 DOI: 10.1038/Nsmb.3138  0.848
2015 Cooper PE, Sala-Rabanal M, Lee SJ, Nichols CG. Differential mechanisms of Cantú syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel. The Journal of General Physiology. 146: 527-40. PMID 26621776 DOI: 10.1085/Jgp.201511495  0.843
2015 Zubcevic L, Wang S, Bavro VN, Lee SJ, Nichols CG, Tucker SJ. Modular Design of the Selectivity Filter Pore Loop in a Novel Family of Prokaryotic 'Inward Rectifier' (NirBac) channels. Scientific Reports. 5: 15305. PMID 26470642 DOI: 10.1038/Srep15305  0.59
2015 Li DC, Nichols CG, Sala-Rabanal M. Role of a Hydrophobic Pocket in Polyamine Interactions with the Polyspecific Organic Cation Transporter OCT3. The Journal of Biological Chemistry. PMID 26405039 DOI: 10.1074/Jbc.M115.668913  0.37
2015 Henn MC, Janjua MB, Kanter EM, Makepeace CM, Schuessler RB, Nichols CG, Lawton JS. Adenosine Triphosphate-Sensitive Potassium Channel Kir Subunits Implicated in Cardioprotection by Diazoxide. Journal of the American Heart Association. 4: e002016. PMID 26304939 DOI: 10.1161/JAHA.115.002016  0.496
2015 Baier LJ, Muller YL, Remedi MS, Traurig M, Piaggi P, Wiessner G, Huang K, Stacy A, Kobes S, Krakoff J, Bennett PH, Nelson RG, Knowler WC, Hanson RL, Nichols CG, et al. ABCC8 R1420H loss-of-function variant in a Southwest American Indian community: association with increased birth weight and doubled risk of type 2 diabetes. Diabetes. PMID 26246406 DOI: 10.2337/db15-0459  0.327
2015 Nelson PT, Jicha GA, Wang WX, Ighodaro E, Artiushin S, Nichols CG, Fardo DW. ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target. Ageing Research Reviews. PMID 26226329 DOI: 10.1016/j.arr.2015.07.007  0.323
2015 Levin MD, Zhang H, Uchida K, Grange DK, Singh GK, Nichols CG. Electrophysiological Consequences of Katp Gain-of-Function In the Heart: Conduction Abnormalities In Cantu Syndrome. Heart Rhythm : the Official Journal of the Heart Rhythm Society. PMID 26142302 DOI: 10.1016/j.hrthm.2015.06.042  0.444
2015 Henn MC, Janjua MB, Zhang H, Kanter EM, Makepeace CM, Schuessler RB, Nichols CG, Lawton JS. Diazoxide Cardioprotection Is Independent of Adenosine Triphosphate-Sensitive Potassium Channel Kir6.1 Subunit in Response to Stress. Journal of the American College of Surgeons. PMID 25872691 DOI: 10.1016/j.jamcollsurg.2015.02.014  0.605
2015 Linder T, Wang S, Zangerl-Plessl EM, Nichols CG, Stary-Weinzinger A. Molecular Dynamics Simulations of KirBac1.1 Mutants Reveal Global Gating Changes of Kir Channels. Journal of Chemical Information and Modeling. 55: 814-22. PMID 25794351 DOI: 10.1021/acs.jcim.5b00010  0.488
2015 Sala-Rabanal M, Yurtsever Z, Nichols CG, Brett TJ. Secreted CLCA1 modulates TMEM16A to activate Ca(2+)-dependent chloride currents in human cells. Elife. 4. PMID 25781344 DOI: 10.7554/Elife.05875  0.416
2015 Henn MC, Janjua MB, Zhang H, Kanter EM, Makepeace CM, Schuessler R, Nichols CG, Lawton JS. Myocytes with Gain-of-Function of Adenosine Triphosphate-Sensitive Potassium Channel Subunit Kir6.1 Have Altered Response to Stress of Hyperkalemic Cardioplegia Journal of the American College of Surgeons. 221: S25. DOI: 10.1016/J.JAMCOLLSURG.2015.07.045  0.533
2015 Henn MC, Janjua MB, Zhang H, Kanter EM, Makepeace CM, Schuessler R, Nichols CG, Lawton JS. Genetic Deletion of Adenosine Triphosphate-Sensitive Potassium Channel Subunit Kir6.2 Paradoxically Confers Increased Tolerance to Myocyte Stress Journal of the American College of Surgeons. 221: S24. DOI: 10.1016/J.JAMCOLLSURG.2015.07.043  0.518
2015 Li DC, Nichols CG, Sala-Rabanal M. Molecular Determinants of Substrate Selectivity in OCT3 (SLC22A3) Biophysical Journal. 108: 461a. DOI: 10.1016/J.Bpj.2014.11.2516  0.374
2015 Sala-Rabanal M, Yurtsever Z, Nichols CG, Brett TJ. Secreted Human CLCA1 Activates Calcium-Dependent Chloride Currents via Interaction with TMEM16A (Anoctamin 1) Biophysical Journal. 108: 435a. DOI: 10.1016/J.Bpj.2014.11.2376  0.415
2015 Lee S, Gyore J, Heyman S, Nichols CG. Biphasic Influence of Bulk Anionic Phospholipids for PIP2 Gating of Kir2.1 Channels through Binding to Two Distinct Sites Biophysical Journal. 108: 383a. DOI: 10.1016/J.BPJ.2014.11.2098  0.529
2015 Borschel WF, Wang S, Nichols CG. Intersubunit Interactions Control Kir Channel Inactivation Biophysical Journal. 108: 278a. DOI: 10.1016/J.BPJ.2014.11.1523  0.872
2014 Fürst O, Nichols CG, Lamoureux G, D'Avanzo N. Identification of a cholesterol-binding pocket in inward rectifier K(+) (Kir) channels. Biophysical Journal. 107: 2786-96. PMID 25517146 DOI: 10.1016/J.Bpj.2014.10.066  0.804
2014 Silva JR, Cooper P, Nichols CG. Modeling K,ATP--dependent excitability in pancreatic islets. Biophysical Journal. 107: 2016-26. PMID 25418087 DOI: 10.1016/J.Bpj.2014.09.037  0.807
2014 Janjua MB, Makepeace CM, Anastacio MM, Schuessler RB, Nichols CG, Lawton JS. Cardioprotective benefits of adenosine triphosphate-sensitive potassium channel opener diazoxide are lost with administration after the onset of stress in mouse and human myocytes. Journal of the American College of Surgeons. 219: 803-13. PMID 25158912 DOI: 10.1016/j.jamcollsurg.2014.05.010  0.324
2014 Cooper PE, Reutter H, Woelfle J, Engels H, Grange DK, van Haaften G, van Bon BW, Hoischen A, Nichols CG. Cantú syndrome resulting from activating mutation in the KCNJ8 gene. Human Mutation. 35: 809-13. PMID 24700710 DOI: 10.1002/Humu.22555  0.836
2014 Raphemot R, Swale DR, Dadi PK, Jacobson DA, Cooper P, Wojtovich AP, Banerjee S, Nichols CG, Denton JS. Direct activation of β-cell KATP channels with a novel xanthine derivative. Molecular Pharmacology. 85: 858-65. PMID 24646456 DOI: 10.1124/Mol.114.091884  0.839
2014 Arakel EC, Brandenburg S, Uchida K, Zhang H, Lin YW, Kohl T, Schrul B, Sulkin MS, Efimov IR, Nichols CG, Lehnart SE, Schwappach B. Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes. Journal of Cell Science. 127: 2106-19. PMID 24569881 DOI: 10.1242/Jcs.141440  0.727
2014 Zubcevic L, Bavro VN, Muniz JR, Schmidt MR, Wang S, De Zorzi R, Venien-Bryan C, Sansom MS, Nichols CG, Tucker SJ. Control of KirBac3.1 potassium channel gating at the interface between cytoplasmic domains. The Journal of Biological Chemistry. 289: 143-51. PMID 24257749 DOI: 10.1074/Jbc.M113.501833  0.624
2014 Yurtsever Z, Sala-Rabanal M, Nichols CG, Brett TJ. Mechanism of CLCA1-Mediated CACC Activation in Chronic Lung Diseases Biophysical Journal. 106: 751a. DOI: 10.1016/J.Bpj.2013.11.4136  0.524
2014 Wang S, Vafabakhsh R, Borschel W, Ha T, Nichols CG. Structural Dynamics Underlying Pip2 Modulation of Kir Channels Revealed by Single Molecule FRET Biophysical Journal. 106: 748a. DOI: 10.1016/J.Bpj.2013.11.4119  0.845
2014 Lee SJ, Wang S, Borschel W, Heyman S, Gyore J, Nichols CG. Unique Anionic Phospholipid Binding Site and Gating Mechanism in Kir2.1 Inward Rectifier Channels Biophysical Journal. 106: 747a-748a. DOI: 10.1016/J.BPJ.2013.11.4118  0.837
2014 Cooper P, Sala-Rabanal M, Nichols C. Mechanisms of ATP-Sensitive Potassium Channel Overactivity in Cantu Mutants Biophysical Journal. 106: 552a. DOI: 10.1016/J.Bpj.2013.11.3071  0.831
2014 Varga Z, Schubert AR, Asaro AB, Cui J, Zaydman MA, Nichols CG, Silva JR. Distinct Voltage Sensor Gating of Cardiac NaV Channels Biophysical Journal. 106: 36a-37a. DOI: 10.1016/J.Bpj.2013.11.277  0.711
2013 Lee SJ, Wang S, Borschel W, Heyman S, Gyore J, Nichols CG. Secondary anionic phospholipid binding site and gating mechanism in Kir2.1 inward rectifier channels. Nature Communications. 4: 2786. PMID 24270915 DOI: 10.1038/ncomms3786  0.825
2013 Anastacio MM, Kanter EM, Makepeace CM, Keith AD, Zhang H, Schuessler RB, Nichols CG, Lawton JS. Relationship between mitochondrial matrix volume and cellular volume in response to stress and the role of ATP-sensitive potassium channel. Circulation. 128: S130-5. PMID 24030396 DOI: 10.1161/CIRCULATIONAHA.112.000128  0.366
2013 Bukovnik U, Sala-Rabanal M, Francis S, Frazier SJ, Schultz BD, Nichols CG, Tomich JM. Effect of diaminopropionic acid (Dap) on the biophysical properties of a modified synthetic channel-forming peptide. Molecular Pharmaceutics. 10: 3959-66. PMID 24010543 DOI: 10.1021/Mp4002377  0.495
2013 Li A, Knutsen RH, Zhang H, Osei-Owusu P, Moreno-Dominguez A, Harter TM, Uchida K, Remedi MS, Dietrich HH, Bernal-Mizrachi C, Blumer KJ, Mecham RP, Koster JC, Nichols CG. Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle. Journal of the American Heart Association. 2: e000365. PMID 23974906 DOI: 10.1161/Jaha.113.000365  0.32
2013 Zhang HX, Silva JR, Lin YW, Verbsky JW, Lee US, Kanter EM, Yamada KA, Schuessler RB, Nichols CG. Heterogeneity and function of K(ATP) channels in canine hearts. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 10: 1576-83. PMID 23871704 DOI: 10.1016/J.Hrthm.2013.07.020  0.768
2013 Lin YW, Li A, Grasso V, Battaglia D, Crinò A, Colombo C, Barbetti F, Nichols CG. Functional characterization of a novel KCNJ11 in frame mutation-deletion associated with infancy-onset diabetes and a mild form of intermediate DEND: a battle between K(ATP) gain of channel activity and loss of channel expression. Plos One. 8: e63758. PMID 23667671 DOI: 10.1371/journal.pone.0063758  0.729
2013 Anastacio MM, Kanter EM, Makepeace C, Keith AD, Zhang H, Schuessler RB, Nichols CG, Lawton JS. Cardioprotective mechanism of diazoxide involves the inhibition of succinate dehydrogenase. The Annals of Thoracic Surgery. 95: 2042-50. PMID 23642436 DOI: 10.1016/j.athoracsur.2013.03.035  0.498
2013 Glukhov AV, Uchida K, Efimov IR, Nichols CG. Functional roles of KATP channel subunits in metabolic inhibition. Journal of Molecular and Cellular Cardiology. 62: 90-8. PMID 23624089 DOI: 10.1016/J.Yjmcc.2013.04.016  0.404
2013 D'Avanzo N, McCusker EC, Powl AM, Miles AJ, Nichols CG, Wallace BA. Differential lipid dependence of the function of bacterial sodium channels. Plos One. 8: e61216. PMID 23579615 DOI: 10.1371/Journal.Pone.0061216  0.804
2013 D'Avanzo N, Lee SJ, Cheng WW, Nichols CG. Energetics and location of phosphoinositide binding in human Kir2.1 channels. The Journal of Biological Chemistry. 288: 16726-37. PMID 23564459 DOI: 10.1074/Jbc.M113.452540  0.833
2013 Nichols CG, Singh GK, Grange DK. KATP channels and cardiovascular disease: suddenly a syndrome. Circulation Research. 112: 1059-72. PMID 23538276 DOI: 10.1161/CIRCRESAHA.112.300514  0.574
2013 Anastacio MM, Kanter EM, Keith AD, Schuessler RB, Nichols CG, Lawton JS. Inhibition of Succinate Dehydrogenase by Diazoxide Is Independent of the ATP-Sensitive Potassium Channel Subunit Sulfonylurea Type 1 Receptor. Journal of the American College of Surgeons. 216: 1144-9. PMID 23535164 DOI: 10.1016/j.jamcollsurg.2013.01.048  0.57
2013 Sala-Rabanal M, Li DC, Dake GR, Kurata HT, Inyushin M, Skatchkov SN, Nichols CG. Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2, and OCT3. Molecular Pharmaceutics. 10: 1450-8. PMID 23458604 DOI: 10.1021/Mp400024D  0.378
2013 Kurata HT, Akrouh A, Li JB, Marton LJ, Nichols CG. Scanning the topography of polyamine blocker binding in an inwardly rectifying potassium channel. The Journal of Biological Chemistry. 288: 6591-601. PMID 23300089 DOI: 10.1074/jbc.M112.383794  0.499
2013 Wang S, Makhina EN, Masia R, Hyrc KL, Formanack ML, Nichols CG. Domain organization of the ATP-sensitive potassium channel complex examined by fluorescence resonance energy transfer. The Journal of Biological Chemistry. 288: 4378-88. PMID 23223337 DOI: 10.1074/Jbc.M112.388629  0.701
2013 Janjua MB, Makepeace CM, Anastacio MM, Schuessler RB, Nichols CG, Lawton JS. The cardioprotective benefits of KATP channel opener diazoxide are lost with administration after the onset of stress in mouse and human myocytes Journal of the American College of Surgeons. 217: S37. DOI: 10.1016/J.JAMCOLLSURG.2013.07.072  0.505
2013 Levin M, Zhang H, Uchida K, Nichols C. Transgenic Expression of Kir6.1 Gain-of-Function Mutations in the Mouse Heart Result in Increased L-Type Calcium Current in Ventricular Myocytes Heart Rhythm. 10: 1741. DOI: 10.1016/J.HRTHM.2013.09.013  0.349
2013 Asaro AB, Zaydman MA, Wong N, Schubert AR, Rudokas M, Cui J, Nichols CG, Silva JR. Applying Voltage Clamp Fluorometry to Track SCN5A Voltage Sensor Movement Biophysical Journal. 104: 138a. DOI: 10.1016/J.Bpj.2012.11.785  0.682
2013 Wang S, Heyman S, Enkvetchakul D, Nichols CG. Gating Motions of KirBac1.1 Cytoplasmic Domain with Respect to Transmembrane Domain Revealed by FRET Biophysical Journal. 104: 129a. DOI: 10.1016/J.BPJ.2012.11.739  0.412
2013 D'Avanzo N, Nichols CG. Identification of a Cholesterol Binding Pocket in Bacterial and Eukaryotic Inward Rectifier K+ (Kir) Channels Biophysical Journal. 104: 97a. DOI: 10.1016/J.Bpj.2012.11.573  0.804
2013 Lee S, Gyore J, Nichols CG. Identification of the Regulatory Anionic Lipid Site in Kir Channels Biophysical Journal. 104: 433a. DOI: 10.1016/J.BPJ.2012.11.2408  0.553
2013 D'Avanzo N, McCusker EC, Powl AM, Miles AJ, Nichols CG, Wallace BA. Differential Lipid Dependence of Function of Bacterial Sodium Channel Homologues Biophysical Journal. 104: 14a. DOI: 10.1016/J.Bpj.2012.11.108  0.792
2013 Zhang HX, Silva JR, Nichols CG. Cardiac KATP channels in health and diseases Electrical Diseases of the Heart. 1: 259-279. DOI: 10.1007/978-1-4471-4881-4_16  0.641
2012 Yurtsever Z, Sala-Rabanal M, Randolph DT, Scheaffer SM, Roswit WT, Alevy YG, Patel AC, Heier RF, Romero AG, Nichols CG, Holtzman MJ, Brett TJ. Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation. The Journal of Biological Chemistry. 287: 42138-49. PMID 23112050 DOI: 10.1074/Jbc.M112.410282  0.523
2012 Benedikt J, Inyushin M, Kucheryavykh YV, Rivera Y, Kucheryavykh LY, Nichols CG, Eaton MJ, Skatchkov SN. Intracellular polyamines enhance astrocytic coupling. Neuroreport. 23: 1021-5. PMID 23076119 DOI: 10.1097/WNR.0b013e32835aa04b  0.349
2012 McCusker EC, Bagnéris C, Naylor CE, Cole AR, D'Avanzo N, Nichols CG, Wallace BA. Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing. Nature Communications. 3: 1102. PMID 23033078 DOI: 10.1038/Ncomms2077  0.832
2012 Nichols CG, Remedi MS. The diabetic β-cell: hyperstimulated vs. hyperexcited. Diabetes, Obesity & Metabolism. 14: 129-35. PMID 22928573 DOI: 10.1111/j.1463-1326.2012.01655.x  0.372
2012 Ponce-Balbuena D, Rodríguez-Menchaca AA, López-Izquierdo A, Ferrer T, Kurata HT, Nichols CG, Sánchez-Chapula JA. Molecular mechanisms of chloroquine inhibition of heterologously expressed Kir6.2/SUR2A channels. Molecular Pharmacology. 82: 803-13. PMID 22851715 DOI: 10.1124/mol.112.079152  0.668
2012 Toib A, Zhang HX, Broekelmann TJ, Hyrc KL, Guo Q, Chen F, Remedi MS, Nichols CG. Cardiac specific ATP-sensitive K+ channel (KATP) overexpression results in embryonic lethality. Journal of Molecular and Cellular Cardiology. 53: 437-45. PMID 22796573 DOI: 10.1016/j.yjmcc.2012.07.001  0.502
2012 Battaglia D, Lin YW, Brogna C, Crinò A, Grasso V, Mozzi AF, Russo L, Spera S, Colombo C, Ricci S, Nichols CG, Mercuri E, Barbetti F. Glyburide ameliorates motor coordination and glucose homeostasis in a child with diabetes associated with the KCNJ11/S225T, del226-232 mutation. Pediatric Diabetes. 13: 656-60. PMID 22694282 DOI: 10.1111/j.1399-5448.2012.00874.x  0.549
2012 Lin YW, Akrouh A, Hsu Y, Hughes N, Nichols CG, De León DD. Compound heterozygous mutations in the SUR1 (ABCC 8) subunit of pancreatic K(ATP) channels cause neonatal diabetes by perturbing the coupling between Kir6.2 and SUR1 subunits. Channels (Austin, Tex.). 6: 133-8. PMID 22562119 DOI: 10.4161/chan.19980  0.742
2012 Finol-Urdaneta RK, Remedi MS, Raasch W, Becker S, Clark RB, Strüver N, Pavlov E, Nichols CG, French RJ, Terlau H. Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion. Embo Molecular Medicine. 4: 424-34. PMID 22438204 DOI: 10.1002/emmm.201200218  0.434
2012 Sala-Rabanal M, Wang S, Nichols CG. On potential interactions between non-selective cation channel TRPM4 and sulfonylurea receptor SUR1. The Journal of Biological Chemistry. 287: 8746-56. PMID 22291026 DOI: 10.1074/jbc.M111.336131  0.632
2012 Wang S, Lee SJ, Heyman S, Enkvetchakul D, Nichols CG. Structural rearrangements underlying ligand-gating in Kir channels. Nature Communications. 3: 617. PMID 22233627 DOI: 10.1038/ncomms1625  0.526
2012 Remedi MS, Nichols CG. Biochemistry and physiology of the ATP-sensitive potassium channel Frontiers in Diabetes. 21: 7-17. DOI: 10.1159/000334464  0.554
2012 Anastacio MM, Sellitto AD, Kanter EM, Schuessler RD, Nichols CG, Lawton JS. The cardioprotective mechanism of diazoxide is not via the inhibition of succinate dehydrogenase independent of K-ATP channel subunit SUR1 Journal of the American College of Surgeons. 215: S35-S36. DOI: 10.1016/J.JAMCOLLSURG.2012.06.111  0.589
2012 Zhang H, Silva J, Lin Y, Verbsky J, Lee U, Kanter E, Yamada K, Schuessler R, Nichols C. Heterogeneity and Function of ATP-Sensitive Potassium Channels in Canine Hearts Heart Rhythm. 9: 1917. DOI: 10.1016/J.Hrthm.2012.09.112  0.737
2012 Joo Lee S, D'Avanzo N, Nichols CG, Huettner JE. Purification and In Vitro Functional Analysis of Glutamate Receptor Biophysical Journal. 102: 115a. DOI: 10.1016/J.Bpj.2011.11.647  0.758
2012 D'Avanzo N, Lee S, Cheng WW, Nichols CG. The Molecular Basis of Phosphoinositide Activation of Human Inward Rectifier (Kir2.1) Channels Biophysical Journal. 102: 536a. DOI: 10.1016/J.Bpj.2011.11.2931  0.833
2012 Wang S, Heyman S, Enkvetchakul D, Nichols CG. Molecular Basis of Pip2 Gating KirBac1.1 Biophysical Journal. 102: 536a. DOI: 10.1016/J.BPJ.2011.11.2930  0.539
2012 Sala-Rabanal M, Wang S, Nichols CG. On the Potential Interaction between Non-Selective Cation Channel TRPM4 and the Sulfonylurea Receptor SUR1 Biophysical Journal. 102: 343a-344a. DOI: 10.1016/J.BPJ.2011.11.1883  0.633
2012 Zhang H, Lin Y, Verbsky JW, Sellitto AD, Uchida K, Janks D, Lee US, Kanter EM, Yamada KA, Efimov IR, Lawton JS, Schuessler RB, Nichols CG. Sulfonylurea Receptor Subunit Composition of KATP Channels in Dog and Human Hearts Biophysical Journal. 102: 339a. DOI: 10.1016/J.Bpj.2011.11.1859  0.61
2012 Uchida K, Glukhov A, Xia Zhang H, Sulkin M, Laughner J, Kostecki G, Efimov I, Nichols C. Optical Mapping of Cardiac ATP Sensitive Potassium Channel Function under Metabolic Inhibition Biophysical Journal. 102: 339a. DOI: 10.1016/J.Bpj.2011.11.1858  0.358
2011 Flagg TP, Nichols CG. "Cardiac KATP": a family of ion channels. Circulation. Arrhythmia and Electrophysiology. 4: 796-8. PMID 22203659 DOI: 10.1161/CIRCEP.111.968081  0.591
2011 Sellitto AD, Al-Dadah AS, Schuessler RB, Nichols CG, Lawton JS. An open sarcolemmal adenosine triphosphate-sensitive potassium channel is necessary for detrimental myocyte swelling secondary to stress. Circulation. 124: S70-4. PMID 21911821 DOI: 10.1161/CIRCULATIONAHA.110.012039  0.593
2011 Remedi MS, Agapova SE, Vyas AK, Hruz PW, Nichols CG. Acute sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetes. Diabetes. 60: 2515-22. PMID 21813803 DOI: 10.2337/db11-0538  0.316
2011 Fedorov VV, Glukhov AV, Ambrosi CM, Kostecki G, Chang R, Janks D, Schuessler RB, Moazami N, Nichols CG, Efimov IR. Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. Journal of Molecular and Cellular Cardiology. 51: 215-25. PMID 21586291 DOI: 10.1016/J.Yjmcc.2011.04.016  0.414
2011 D'Avanzo N, Hyrc K, Enkvetchakul D, Covey DF, Nichols CG. Enantioselective protein-sterol interactions mediate regulation of both prokaryotic and eukaryotic inward rectifier K+ channels by cholesterol. Plos One. 6: e19393. PMID 21559361 DOI: 10.1371/Journal.Pone.0019393  0.824
2011 McCusker EC, D'Avanzo N, Nichols CG, Wallace BA. Simplified bacterial "pore" channel provides insight into the assembly, stability, and structure of sodium channels. The Journal of Biological Chemistry. 286: 16386-91. PMID 21454659 DOI: 10.1074/Jbc.C111.228122  0.832
2011 Cheng WW, McCoy JG, Thompson AN, Nichols CG, Nimigean CM. Mechanism for selectivity-inactivation coupling in KcsA potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 108: 5272-7. PMID 21402935 DOI: 10.1073/pnas.1014186108  0.752
2011 Kurata HT, Cheng WW, Nichols CG. Polyamine block of inwardly rectifying potassium channels. Methods in Molecular Biology (Clifton, N.J.). 720: 113-26. PMID 21318869 DOI: 10.1007/978-1-61779-034-8_6  0.799
2011 Cheng WW, D'Avanzo N, Doyle DA, Nichols CG. Dual-mode phospholipid regulation of human inward rectifying potassium channels. Biophysical Journal. 100: 620-8. PMID 21281576 DOI: 10.1016/J.Bpj.2010.12.3724  0.856
2011 Zhang HX, Akrouh A, Kurata HT, Remedi MS, Lawton JS, Nichols CG. HMR 1098 is not an SUR isotype specific inhibitor of heterologous or sarcolemmal K ATP channels. Journal of Molecular and Cellular Cardiology. 50: 552-60. PMID 21185839 DOI: 10.1016/j.yjmcc.2010.12.011  0.618
2011 Loechner KJ, Akrouh A, Kurata HT, Dionisi-Vici C, Maiorana A, Pizzoferro M, Rufini V, de Ville de Goyet J, Colombo C, Barbetti F, Koster JC, Nichols CG. Congenital hyperinsulinism and glucose hypersensitivity in homozygous and heterozygous carriers of Kir6.2 (KCNJ11) mutation V290M mutation: K(ATP) channel inactivation mechanism and clinical management. Diabetes. 60: 209-17. PMID 20980454 DOI: 10.2337/db10-0731  0.571
2011 Bukovnik U, Sala-Rabanal M, Nichols C, Schultz B, Chen J, Tomich J. Synthetic Peptide-Based Channels: Candidates for Treatments of Channelopathies Biophysical Journal. 100: 87a. DOI: 10.1016/J.Bpj.2010.12.681  0.514
2011 D'Avanzo N, Cheng WW, Doyle DA, Nichols CG. Phospholipid Regulation of Purified and Reconstituted Human Inward Rectifier (Kir) Channels Biophysical Journal. 100: 431a. DOI: 10.1016/J.Bpj.2010.12.2545  0.859
2010 D'Avanzo N, Cheng WW, Wang S, Enkvetchakul D, Nichols CG. Lipids driving protein structure? Evolutionary adaptations in Kir channels. Channels (Austin, Tex.). 4: 139-41. PMID 21150302 DOI: 10.4161/Chan.4.3.12129  0.862
2010 D'Avanzo N, Cheng WW, Doyle DA, Nichols CG. Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate. The Journal of Biological Chemistry. 285: 37129-32. PMID 20921230 DOI: 10.1074/Jbc.C110.186692  0.869
2010 Paynter JJ, Andres-Enguix I, Fowler PW, Tottey S, Cheng W, Enkvetchakul D, Bavro VN, Kusakabe Y, Sansom MS, Robinson NJ, Nichols CG, Tucker SJ. Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains. The Journal of Biological Chemistry. 285: 40754-61. PMID 20876570 DOI: 10.1074/Jbc.M110.175687  0.79
2010 Inyushin M, Kucheryavykh LY, Kucheryavykh YV, Nichols CG, Buono RJ, Ferraro TN, Skatchkov SN, Eaton MJ. Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice. Epilepsia. 51: 1707-13. PMID 20831751 DOI: 10.1111/j.1528-1167.2010.02592.x  0.438
2010 Sala-Rabanal M, Kucheryavykh LY, Skatchkov SN, Eaton MJ, Nichols CG. Molecular mechanisms of EAST/SeSAME syndrome mutations in Kir4.1 (KCNJ10). The Journal of Biological Chemistry. 285: 36040-8. PMID 20807765 DOI: 10.1074/jbc.M110.163170  0.593
2010 Sellitto AD, Maffit SK, Al-Dadah AS, Zhang H, Schuessler RB, Nichols CG, Lawton JS. Diazoxide maintenance of myocyte volume and contractility during stress: evidence for a non-sarcolemmal K(ATP) channel location. The Journal of Thoracic and Cardiovascular Surgery. 140: 1153-9. PMID 20804990 DOI: 10.1016/j.jtcvs.2010.07.047  0.592
2010 Flagg TP, Enkvetchakul D, Koster JC, Nichols CG. Muscle KATP channels: recent insights to energy sensing and myoprotection. Physiological Reviews. 90: 799-829. PMID 20664073 DOI: 10.1152/physrev.00027.2009  0.563
2010 Aw S, Koster JC, Pearson W, Nichols CG, Shi NQ, Carneiro K, Levin M. The ATP-sensitive K(+)-channel (K(ATP)) controls early left-right patterning in Xenopus and chick embryos. Developmental Biology. 346: 39-53. PMID 20643119 DOI: 10.1016/J.Ydbio.2010.07.011  0.563
2010 Kurata HT, Zhu EA, Nichols CG. Locale and chemistry of spermine binding in the archetypal inward rectifier Kir2.1. The Journal of General Physiology. 135: 495-508. PMID 20421374 DOI: 10.1085/jgp.200910253  0.424
2010 Kurata HT, Rapedius M, Kleinman MJ, Baukrowitz T, Nichols CG. Voltage-dependent gating in a "voltage sensor-less" ion channel. Plos Biology. 8: e1000315. PMID 20208975 DOI: 10.1371/journal.pbio.1000315  0.586
2010 D'Avanzo N, Cheng WW, Xia X, Dong L, Savitsky P, Nichols CG, Doyle DA. Expression and purification of recombinant human inward rectifier K+ (KCNJ) channels in Saccharomyces cerevisiae. Protein Expression and Purification. 71: 115-21. PMID 20064617 DOI: 10.1016/J.Pep.2010.01.010  0.864
2010 Ellis JA, Lamantia A, Chavez R, Scurrah KJ, Nichols CG, Harrap SB. Genes controlling postural changes in blood pressure: comprehensive association analysis of ATP-sensitive potassium channel genes KCNJ8 and ABCC9. Physiological Genomics. 40: 184-8. PMID 19952277 DOI: 10.1152/physiolgenomics.00173.2009  0.416
2010 Haim TE, Wang W, Flagg TP, Tones MA, Bahinski A, Numann RE, Nichols CG, Nerbonne JM. Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents. Journal of Molecular and Cellular Cardiology. 48: 395-405. PMID 19857498 DOI: 10.1016/J.Yjmcc.2009.10.004  0.398
2010 Glukhov AV, Flagg TP, Fedorov VV, Efimov IR, Nichols CG. Differential K(ATP) channel pharmacology in intact mouse heart. Journal of Molecular and Cellular Cardiology. 48: 152-60. PMID 19744493 DOI: 10.1016/J.Yjmcc.2009.08.026  0.381
2010 Wambach JA, Marshall BA, Koster JC, White NH, Nichols CG. Successful sulfonylurea treatment of an insulin-naïve neonate with diabetes mellitus due to a KCNJ11 mutation. Pediatric Diabetes. 11: 286-8. PMID 19656320 DOI: 10.1111/j.1399-5448.2009.00557.x  0.352
2010 Zhang H, Flagg TP, Nichols CG. Cardiac sarcolemmal K(ATP) channels: Latest twists in a questing tale! Journal of Molecular and Cellular Cardiology. 48: 71-5. PMID 19607836 DOI: 10.1016/j.yjmcc.2009.07.002  0.607
2010 Zhang H, Akrouh A, Kurata HT, Remedi MS, Nichols CG. HMR 1098 is not an Sur Isotype Specific Inhibitor of Sarcolemmal or Heterologous KATP Channels Biophysical Journal. 98: 137a-138a. DOI: 10.1016/J.BPJ.2009.12.742  0.643
2010 D'Avanzo N, Cheng WW, Dong L, Nichols CG, Doyle DA. Expression and Purification of Recombinant Human Inward Rectifier K+ (KCNJ) Channel Biophysical Journal. 98: 701a. DOI: 10.1016/J.Bpj.2009.12.3845  0.863
2010 Cheng WW, D'Avanzo N, Enkvetchakul D, Nichols CG. The Lipid Dependence of Purified and Reconstituted Kir2.1 and Kir2.2 Biophysical Journal. 98: 700a. DOI: 10.1016/J.Bpj.2009.12.3842  0.858
2010 Sala-Rabanal M, Eaton MJ, Nichols CG. Functional Characterization of Mutations in Kir4.1 (KCNJ10) Associated with the SeSAME Syndrome Biophysical Journal. 98: 699a. DOI: 10.1016/J.BPJ.2009.12.3836  0.545
2010 Wang S, Heyman S, Enkvetchakul D, Nichols CG. Structural Dynamics of KirBac1.1 Probed by Fluorescent Labeling and FRET Biophysical Journal. 98: 696a. DOI: 10.1016/J.BPJ.2009.12.3820  0.448
2010 Benninger RK, Remedi MS, Ustione A, Head WS, Nichols CG, Piston DW. Metabolism-Excitation Coupling in a Model of KATP Channel Neonatal Diabetes Mellitus Biophysical Journal. 98: 578a. DOI: 10.1016/J.Bpj.2009.12.3140  0.424
2010 Cheng WW, Nichols CG. The E71A Mutation Alters Selective Ion Permeability in KcsA Biophysical Journal. 98: 332a. DOI: 10.1016/j.bpj.2009.12.1800  0.757
2010 Kurata HT, Nichols CG. Inwardly Rectifying Potassium Channels Encyclopedia of Neuroscience. 213-219. DOI: 10.1016/B978-008045046-9.01635-1  0.564
2009 Kline CF, Kurata HT, Hund TJ, Cunha SR, Koval OM, Wright PJ, Christensen M, Anderson ME, Nichols CG, Mohler PJ. Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation. Proceedings of the National Academy of Sciences of the United States of America. 106: 16669-74. PMID 19805355 DOI: 10.1073/Pnas.0907138106  0.601
2009 Akrouh A, Halcomb SE, Nichols CG, Sala-Rabanal M. Molecular biology of K(ATP) channels and implications for health and disease. Iubmb Life. 61: 971-8. PMID 19787700 DOI: 10.1002/iub.246  0.578
2009 Singh DK, Rosenhouse-Dantsker A, Nichols CG, Enkvetchakul D, Levitan I. Direct regulation of prokaryotic Kir channel by cholesterol. The Journal of Biological Chemistry. 284: 30727-36. PMID 19740741 DOI: 10.1074/Jbc.M109.011221  0.543
2009 Lefer DJ, Nichols CG, Coetzee WA. Sulfonylurea receptor 1 subunits of ATP-sensitive potassium channels and myocardial ischemia/reperfusion injury. Trends in Cardiovascular Medicine. 19: 61-7. PMID 19577714 DOI: 10.1016/J.Tcm.2009.04.008  0.56
2009 Villareal DT, Koster JC, Robertson H, Akrouh A, Miyake K, Bell GI, Patterson BW, Nichols CG, Polonsky KS. Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance. Diabetes. 58: 1869-78. PMID 19491206 DOI: 10.2337/Db09-0025  0.392
2009 Cheng WW, Enkvetchakul D, Nichols CG. KirBac1.1: it's an inward rectifying potassium channel. The Journal of General Physiology. 133: 295-305. PMID 19204189 DOI: 10.1085/jgp.200810125  0.812
2009 Remedi MS, Kurata HT, Scott A, Wunderlich FT, Rother E, Kleinridders A, Tong A, Brüning JC, Koster JC, Nichols CG. Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus. Cell Metabolism. 9: 140-51. PMID 19187772 DOI: 10.1016/j.cmet.2008.12.005  0.41
2009 Wang S, Alimi Y, Tong A, Nichols CG, Enkvetchakul D. Differential roles of blocking ions in KirBac1.1 tetramer stability. The Journal of Biological Chemistry. 284: 2854-60. PMID 19033439 DOI: 10.1074/jbc.M807474200  0.497
2009 Wang S, Alimi Y, Tong A, Nichols CG, Enkvetchakul D. Stabilization of KirBac1.1 Tetramer by Blocking Ions Biophysical Journal. 96: 467a. DOI: 10.1016/J.BPJ.2008.12.2404  0.495
2009 Kurata HT, Akrouh A, Zhu EA, Nichols CG. Electrostatic Interactions Between Polyamines And Charged Adducts In The Kir Inner Cavity Biophysical Journal. 96: 465a. DOI: 10.1016/j.bpj.2008.12.2396  0.483
2008 Flagg TP, Kurata HT, Masia R, Caputa G, Magnuson MA, Lefer DJ, Coetzee WA, Nichols CG. Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1. Circulation Research. 103: 1458-65. PMID 18974387 DOI: 10.1161/Circresaha.108.178186  0.747
2008 Remedi MS, Nichols CG. Chronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cells. Plos Medicine. 5: e206. PMID 18959471 DOI: 10.1371/journal.pmed.0050206  0.425
2008 Hu X, Xu X, Huang Y, Fassett J, Flagg TP, Zhang Y, Nichols CG, Bache RJ, Chen Y. Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload. Circulation Research. 103: 1009-17. PMID 18802029 DOI: 10.1161/CIRCRESAHA.107.170795  0.413
2008 Masia R, Nichols CG. Functional clustering of mutations in the dimer interface of the nucleotide binding folds of the sulfonylurea receptor. The Journal of Biological Chemistry. 283: 30322-9. PMID 18715873 DOI: 10.1074/Jbc.M804318200  0.779
2008 Koster JC, Kurata HT, Enkvetchakul D, Nichols CG. DEND mutation in Kir6.2 (KCNJ11) reveals a flexible N-terminal region critical for ATP-sensing of the KATP channel. Biophysical Journal. 95: 4689-97. PMID 18708460 DOI: 10.1529/biophysj.108.138685  0.575
2008 Cheng WW, Tong A, Flagg TP, Nichols CG. Random assembly of SUR subunits in K(ATP) channel complexes. Channels (Austin, Tex.). 2: 34-8. PMID 18690055 DOI: 10.4161/chan.2.1.6046  0.793
2008 Kurata HT, Diraviyam K, Marton LJ, Nichols CG. Blocker protection by short spermine analogs: refined mapping of the spermine binding site in a Kir channel. Biophysical Journal. 95: 3827-39. PMID 18641062 DOI: 10.1529/biophysj.108.133256  0.493
2008 Sha Q, Pearson W, Burcea LC, Wigfall DA, Schlesinger PH, Nichols CG, Mercer RW. Human FXYD2 G41R mutation responsible for renal hypomagnesemia behaves as an inward-rectifying cation channel. American Journal of Physiology. Renal Physiology. 295: F91-9. PMID 18448590 DOI: 10.1152/Ajprenal.00519.2007  0.385
2008 Elrod JW, Harrell M, Flagg TP, Gundewar S, Magnuson MA, Nichols CG, Coetzee WA, Lefer DJ. Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury. Circulation. 117: 1405-13. PMID 18316485 DOI: 10.1161/Circulationaha.107.745539  0.578
2008 Kucheryavykh YV, Shuba YM, Antonov SM, Inyushin MY, Cubano L, Pearson WL, Kurata H, Reichenbach A, Veh RW, Nichols CG, Eaton MJ, Skatchkov SN. Complex rectification of Müller cell Kir currents. Glia. 56: 775-90. PMID 18293411 DOI: 10.1002/Glia.20652  0.477
2008 Koster JC, Cadario F, Peruzzi C, Colombo C, Nichols CG, Barbetti F. The G53D mutation in Kir6.2 (KCNJ11) is associated with neonatal diabetes and motor dysfunction in adulthood that is improved with sulfonylurea therapy. The Journal of Clinical Endocrinology and Metabolism. 93: 1054-61. PMID 18073297 DOI: 10.1210/jc.2007-1826  0.458
2008 Singh DK, Enkvetchakul D, Nichols CG, Levitan I. Kirbac 1.1 activity in liposomes is suppressed by cholesterol The Faseb Journal. 22: 84-84. DOI: 10.1096/Fasebj.22.2_Supplement.84  0.5
2008 Nichols CG, Flagg TP. Ion channels (genetics) Access Science. DOI: 10.1036/1097-8542.Yb081460  0.525
2007 Masia R, Caputa G, Nichols CG. Regulation of KATP channel expression and activity by the SUR1 nucleotide binding fold 1. Channels (Austin, Tex.). 1: 315-23. PMID 18708750 DOI: 10.4161/Chan.5083  0.8
2007 Kucheryavykh YV, Pearson WL, Kurata HT, Eaton MJ, Skatchkov SN, Nichols CG. Polyamine permeation and rectification of Kir4.1 channels. Channels (Austin, Tex.). 1: 172-8. PMID 18690029 DOI: 10.4161/Chan.4389  0.618
2007 Nichols CG. Alchemy in the soup: transforming metabolic signals to excitability. Science's Stke : Signal Transduction Knowledge Environment. 2007: pe59. PMID 17971567 DOI: 10.1126/stke.4102007pe59  0.549
2007 Nichols CG, Koster JC, Remedi MS. beta-cell hyperexcitability: from hyperinsulinism to diabetes. Diabetes, Obesity & Metabolism. 9: 81-8. PMID 17919182 DOI: 10.1111/j.1463-1326.2007.00778.x  0.56
2007 Enkvetchakul D, Jeliazkova I, Bhattacharyya J, Nichols CG. Control of inward rectifier K channel activity by lipid tethering of cytoplasmic domains. The Journal of General Physiology. 130: 329-34. PMID 17698595 DOI: 10.1085/jgp.200709764  0.607
2007 Kurata HT, Cheng WW, Arrabit C, Slesinger PA, Nichols CG. The role of the cytoplasmic pore in inward rectification of Kir2.1 channels. The Journal of General Physiology. 130: 145-55. PMID 17635958 DOI: 10.1085/Jgp.200709742  0.717
2007 Flagg TP, Patton B, Masia R, Mansfield C, Lopatin AN, Yamada KA, Nichols CG. Arrhythmia susceptibility and premature death in transgenic mice overexpressing both SUR1 and Kir6.2[DeltaN30,K185Q] in the heart. American Journal of Physiology. Heart and Circulatory Physiology. 293: H836-45. PMID 17449558 DOI: 10.1152/Ajpheart.00011.2007  0.719
2007 Masia R, De Leon DD, MacMullen C, McKnight H, Stanley CA, Nichols CG. A mutation in the TMD0-L0 region of sulfonylurea receptor-1 (L225P) causes permanent neonatal diabetes mellitus (PNDM). Diabetes. 56: 1357-62. PMID 17317760 DOI: 10.2337/Db06-1746  0.766
2007 Masia R, Koster JC, Tumini S, Chiarelli F, Colombo C, Nichols CG, Barbetti F. An ATP-binding mutation (G334D) in KCNJ11 is associated with a sulfonylurea-insensitive form of developmental delay, epilepsy, and neonatal diabetes. Diabetes. 56: 328-36. PMID 17259376 DOI: 10.2337/Db06-1275  0.757
2007 Kucheryavykh YV, Kucheryavykh LY, Nichols CG, Maldonado HM, Baksi K, Reichenbach A, Skatchkov SN, Eaton MJ. Downregulation of Kir4.1 inward rectifying potassium channel subunits by RNAi impairs potassium transfer and glutamate uptake by cultured cortical astrocytes. Glia. 55: 274-81. PMID 17091490 DOI: 10.1002/glia.20455  0.554
2006 Pearson WL, Skatchkov SN, Eaton MJ, Nichols CG. C-terminal determinants of Kir4.2 channel expression. The Journal of Membrane Biology. 213: 187-93. PMID 17468958 DOI: 10.1007/s00232-006-0058-6  0.594
2006 Koster JC, Remedi MS, Masia R, Patton B, Tong A, Nichols CG. Expression of ATP-insensitive KATP channels in pancreatic beta-cells underlies a spectrum of diabetic phenotypes. Diabetes. 55: 2957-64. PMID 17065331 DOI: 10.2337/Db06-0732  0.719
2006 Dobrzynski H, Billeter R, Greener ID, Tellez JO, Chandler NJ, Flagg TP, Nichols CG, Lopatin AN, Boyett MR. Expression of Kir2.1 and Kir6.2 transgenes under the control of the alpha-MHC promoter in the sinoatrial and atrioventricular nodes in transgenic mice. Journal of Molecular and Cellular Cardiology. 41: 855-67. PMID 16996082 DOI: 10.1016/J.Yjmcc.2006.07.018  0.647
2006 Remedi MS, Rocheleau JV, Tong A, Patton BL, McDaniel ML, Piston DW, Koster JC, Nichols CG. Hyperinsulinism in mice with heterozygous loss of K(ATP) channels. Diabetologia. 49: 2368-78. PMID 16924481 DOI: 10.1007/S00125-006-0367-4  0.402
2006 Kurata HT, Marton LJ, Nichols CG. The polyamine binding site in inward rectifier K+ channels. The Journal of General Physiology. 127: 467-80. PMID 16606689 DOI: 10.1085/jgp.200509467  0.569
2006 Nichols CG. KATP channels as molecular sensors of cellular metabolism. Nature. 440: 470-6. PMID 16554807 DOI: 10.1038/nature04711  0.626
2006 Rocheleau JV, Remedi MS, Granada B, Head WS, Koster JC, Nichols CG, Piston DW. Critical role of gap junction coupled KATP channel activity for regulated insulin secretion. Plos Biology. 4: e26. PMID 16402858 DOI: 10.1371/Journal.Pbio.0040026  0.494
2006 Prasad SM, Al-Dadah AS, Byrd GD, Flagg TP, Gomes J, Damiano RJ, Nichols CG, Lawton JS. Role of the sarcolemmal adenosine triphosphate-sensitive potassium channel in hyperkalemic cardioplegia-induced myocyte swelling and reduced contractility. The Annals of Thoracic Surgery. 81: 148-53. PMID 16368354 DOI: 10.1016/j.athoracsur.2005.06.055  0.535
2006 Kurata HT, Nichols CG. Polyamine block of kir channels: Toward a molecular picture Polyamine Cell Signaling: Polyamine Cell Signaling. 383-396. DOI: 10.1007/978-1-59745-145-1_22  0.517
2006 Skatchkov SN, Kucheryavykh YV, Antonov SM, Pearson WL, Nichols CG, Reichenbach A, Eaton MJ. Tandem-pore domain and inwardly rectifying potassium channels: K + buffering by retinal (Müller) glial cells and cortical astrocytes Biologicheskie Membrany. 23: 85-100.  0.411
2005 Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacological Reviews. 57: 509-26. PMID 16382105 DOI: 10.1124/Pr.57.4.11  0.578
2005 Koster JC, Permutt MA, Nichols CG. Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection. Diabetes. 54: 3065-72. PMID 16249427 DOI: 10.2337/diabetes.54.11.3065  0.567
2005 Remedi MS, Koster JC, Patton BL, Nichols CG. ATP-sensitive K+ channel signaling in glucokinase-deficient diabetes. Diabetes. 54: 2925-31. PMID 16186394 DOI: 10.2337/diabetes.54.10.2925  0.474
2005 Enkvetchakul D, Jeliazkova I, Nichols CG. Direct modulation of Kir channel gating by membrane phosphatidylinositol 4,5-bisphosphate. The Journal of Biological Chemistry. 280: 35785-8. PMID 16144841 DOI: 10.1074/jbc.C500355200  0.633
2005 Koster JC, Remedi MS, Dao C, Nichols CG. ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes: implications for pharmacogenomic therapy. Diabetes. 54: 2645-54. PMID 16123353 DOI: 10.2337/diabetes.54.9.2645  0.579
2005 Makary SM, Claydon TW, Enkvetchakul D, Nichols CG, Boyett MR. A difference in inward rectification and polyamine block and permeation between the Kir2.1 and Kir3.1/Kir3.4 K+ channels. The Journal of Physiology. 568: 749-66. PMID 16109731 DOI: 10.1113/jphysiol.2005.085746  0.744
2005 Flagg TP, Remedi MS, Masia R, Gomes J, McLerie M, Lopatin AN, Nichols CG. Transgenic overexpression of SUR1 in the heart suppresses sarcolemmal K(ATP). Journal of Molecular and Cellular Cardiology. 39: 647-56. PMID 16099470 DOI: 10.1016/J.Yjmcc.2005.06.003  0.749
2005 Flagg TP, Nichols CG. Sarcolemmal K(ATP) channels: what do we really know? Journal of Molecular and Cellular Cardiology. 39: 61-70. PMID 15978903 DOI: 10.1016/j.yjmcc.2005.01.005  0.622
2005 Masia R, Enkvetchakul D, Nichols CG. Differential nucleotide regulation of KATP channels by SUR1 and SUR2A. Journal of Molecular and Cellular Cardiology. 39: 491-501. PMID 15893323 DOI: 10.1016/J.Yjmcc.2005.03.009  0.804
2005 Loussouarn G, Marton LJ, Nichols CG. Molecular basis of inward rectification: structural features of the blocker defined by extended polyamine analogs. Molecular Pharmacology. 68: 298-304. PMID 15872118 DOI: 10.1124/mol.105.012377  0.556
2004 Remedi MS, Koster JC, Markova K, Seino S, Miki T, Patton BL, McDaniel ML, Nichols CG. Diet-induced glucose intolerance in mice with decreased beta-cell ATP-sensitive K+ channels. Diabetes. 53: 3159-67. PMID 15561946 DOI: 10.2337/diabetes.53.12.3159  0.465
2004 Kurata HT, Phillips LR, Rose T, Loussouarn G, Herlitze S, Fritzenschaft H, Enkvetchakul D, Nichols CG, Baukrowitz T. Molecular basis of inward rectification: polyamine interaction sites located by combined channel and ligand mutagenesis. The Journal of General Physiology. 124: 541-54. PMID 15477380 DOI: 10.1085/jgp.200409159  0.723
2004 Enkvetchakul D, Bhattacharyya J, Jeliazkova I, Groesbeck DK, Cukras CA, Nichols CG. Functional characterization of a prokaryotic Kir channel. The Journal of Biological Chemistry. 279: 47076-80. PMID 15448150 DOI: 10.1074/jbc.C400417200  0.774
2004 Manning Fox JE, Nichols CG, Light PE. Activation of adenosine triphosphate-sensitive potassium channels by acyl coenzyme A esters involves multiple phosphatidylinositol 4,5-bisphosphate-interacting residues. Molecular Endocrinology (Baltimore, Md.). 18: 679-86. PMID 14694085 DOI: 10.1210/me.2003-0431  0.6
2004 Flagg TP, Charpentier F, Manning-Fox J, Remedi MS, Enkvetchakul D, Lopatin A, Koster J, Nichols CG. Remodeling of excitation-contraction coupling in transgenic mice expressing ATP-insensitive sarcolemmal KATP channels American Journal of Physiology - Heart and Circulatory Physiology. 286: H1361-H1369. PMID 14656703 DOI: 10.1152/Ajpheart.00676.2003  0.544
2004 Nichols CG, Shyng SL, Marshall B, Koster JC. ATP-sensitive potassium channels and insulin secretion diseases Advances in Molecular and Cell Biology. 32: 1-14. DOI: 10.1016/S1569-2558(03)32001-6  0.752
2003 Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, ... Nichols CG, et al. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacological Reviews. 55: 583-6. PMID 14657415 DOI: 10.1124/Pr.55.4.9  0.595
2003 Phillips LR, Nichols CG. Ligand-induced closure of inward rectifier Kir6.2 channels traps spermine in the pore. The Journal of General Physiology. 122: 795-804. PMID 14638936 DOI: 10.1085/jgp.200308953  0.791
2003 Dibb KM, Rose T, Makary SY, Claydon TW, Enkvetchakul D, Leach R, Nichols CG, Boyett MR. Molecular basis of ion selectivity, block, and rectification of the inward rectifier Kir3.1/Kir3.4 K(+) channel. The Journal of Biological Chemistry. 278: 49537-48. PMID 14504281 DOI: 10.1074/jbc.M307723200  0.708
2003 Enkvetchakul D, Ebihara L, Nichols CG. Polyamine flux in Xenopus oocytes through hemi-gap junctional channels. The Journal of Physiology. 553: 95-100. PMID 12963797 DOI: 10.1113/Jphysiol.2003.047910  0.51
2003 Phillips LR, Enkvetchakul D, Nichols CG. Gating dependence of inner pore access in inward rectifier K(+) channels. Neuron. 37: 953-62. PMID 12670424 DOI: 10.1016/S0896-6273(03)00155-7  0.8
2002 Koster JC, Remedi MS, Flagg TP, Johnson JD, Markova KP, Marshall BA, Nichols CG. Hyperinsulinism induced by targeted suppression of beta cell KATP channels. Proceedings of the National Academy of Sciences of the United States of America. 99: 16992-7. PMID 12486236 DOI: 10.1073/Pnas.012479199  0.452
2002 Loussouarn G, Rose T, Nichols CG. Structural basis of inward rectifying potassium channel gating. Trends in Cardiovascular Medicine. 12: 253-8. PMID 12242048 DOI: 10.1016/S1050-1738(02)00170-6  0.631
2002 Cukras CA, Jeliazkova I, Nichols CG. The role of NH2-terminal positive charges in the activity of inward rectifier KATP channels. The Journal of General Physiology. 120: 437-46. PMID 12198096 DOI: 10.1085/jgp.20028621  0.685
2002 Nichols CG, Koster JC. Diabetes and insulin secretion: whither KATP? American Journal of Physiology. Endocrinology and Metabolism. 283: E403-12. PMID 12169432 DOI: 10.1152/ajpendo.00168.2002  0.406
2002 Huopio H, Shyng SL, Otonkoski T, Nichols CG. K(ATP) channels and insulin secretion disorders. American Journal of Physiology. Endocrinology and Metabolism. 283: E207-16. PMID 12110524 DOI: 10.1152/ajpendo.00047.2002  0.775
2002 Cukras CA, Jeliazkova I, Nichols CG. Structural and functional determinants of conserved lipid interaction domains of inward rectifying Kir6.2 channels. The Journal of General Physiology. 119: 581-91. PMID 12034765 DOI: 10.1085/jgp.20028562  0.783
2001 Koster JC, Knopp A, Flagg TP, Markova KP, Sha Q, Enkvetchakul D, Betsuyaku T, Yamada KA, Nichols CG. Tolerance for ATP-insensitive K(ATP) channels in transgenic mice. Circulation Research. 89: 1022-9. PMID 11717159 DOI: 10.1161/Hh2301.100342  0.558
2001 Nerbonne JM, Nichols CG, Schwarz TL, Escande D. Genetic manipulation of cardiac K(+) channel function in mice: what have we learned, and where do we go from here? Circulation Research. 89: 944-56. PMID 11717150 DOI: 10.1161/Hh2301.100349  0.599
2001 Luker GD, Flagg TP, Sha Q, Luker KE, Pica CM, Nichols CG, Piwnica-Worms D. MDR1 P-glycoprotein reduces influx of substrates without affecting membrane potential. The Journal of Biological Chemistry. 276: 49053-60. PMID 11598111 DOI: 10.1074/Jbc.M105192200  0.3
2001 Sha Q, Lansbery KL, Distefano D, Mercer RW, Nichols CG. Heterologous expression of the Na(+),K(+)-ATPase gamma subunit in Xenopus oocytes induces an endogenous, voltage-gated large diameter pore. The Journal of Physiology. 535: 407-17. PMID 11533133 DOI: 10.1111/j.1469-7793.2001.t01-1-00407.x  0.451
2001 Loussouarn G, Pike LJ, Ashcroft FM, Makhina EN, Nichols CG. Dynamic sensitivity of ATP-sensitive K(+) channels to ATP. The Journal of Biological Chemistry. 276: 29098-103. PMID 11395495 DOI: 10.1074/Jbc.M102365200  0.619
2001 Nichols CG, Cukras CA. K(ATP) channel regulators: balanced diets include carbohydrates, proteins, and fats. Circulation Research. 88: 849-51. PMID 11348990 DOI: 10.1161/hh0901.091206  0.805
2001 Loussouarn G, Phillips LR, Masia R, Rose T, Nichols CG. Flexibility of the Kir6.2 inward rectifier K(+) channel pore. Proceedings of the National Academy of Sciences of the United States of America. 98: 4227-32. PMID 11274446 DOI: 10.1073/Pnas.061452698  0.827
2001 Lopatin AN, Nichols CG. Inward rectifiers in the heart: an update on I(K1). Journal of Molecular and Cellular Cardiology. 33: 625-38. PMID 11273717 DOI: 10.1006/Jmcc.2001.1344  0.425
2001 Enkvetchakul D, Loussouarn G, Makhina E, Nichols CG. ATP interaction with the open state of the K(ATP) channel. Biophysical Journal. 80: 719-28. PMID 11159439 DOI: 10.1016/S0006-3495(01)76051-1  0.542
2000 Shyng SL, Cukras CA, Harwood J, Nichols CG. Structural determinants of PIP(2) regulation of inward rectifier K(ATP) channels. The Journal of General Physiology. 116: 599-608. PMID 11055989 DOI: 10.1085/jgp.116.5.599  0.863
2000 Lopatin AN, Shantz LM, Mackintosh CA, Nichols CG, Pegg AE. Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis. Journal of Molecular and Cellular Cardiology. 32: 2007-24. PMID 11040105 DOI: 10.1006/Jmcc.2000.1232  0.325
2000 Gribble FM, Loussouarn G, Tucker SJ, Zhao C, Nichols CG, Ashcroft FM. A novel method for measurement of submembrane ATP concentration. The Journal of Biological Chemistry. 275: 30046-9. PMID 10866996 DOI: 10.1074/Jbc.M001010200  0.42
2000 Enkvetchakul D, Loussouarn G, Makhina E, Shyng SL, Nichols CG. The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding. Biophysical Journal. 78: 2334-48. PMID 10777731 DOI: 10.1016/S0006-3495(00)76779-8  0.763
2000 Shyng SL, Barbieri A, Gumusboga A, Cukras C, Pike L, Davis JN, Stahl PD, Nichols CG. Modulation of nucleotide sensitivity of ATP-sensitive potassium channels by phosphatidylinositol-4-phosphate 5-kinase. Proceedings of the National Academy of Sciences of the United States of America. 97: 937-41. PMID 10639183 DOI: 10.1073/Pnas.97.2.937  0.849
2000 Loussouarn G, Makhina EN, Rose T, Nichols CG. Structure and dynamics of the pore of inwardly rectifying K(ATP) channels. The Journal of Biological Chemistry. 275: 1137-44. PMID 10625656 DOI: 10.1074/jbc.275.2.1137  0.546
1999 Shyng SL, Nichols CG. Nucleotides and insulin secretion. Nutrition (Burbank, Los Angeles County, Calif.). 15: 717-9. PMID 10467619 DOI: 10.1016/S0899-9007(99)00126-4  0.563
1999 Koster JC, Sha Q, Nichols CG. Sulfonylurea and K(+)-channel opener sensitivity of K(ATP) channels. Functional coupling of Kir6.2 and SUR1 subunits. The Journal of General Physiology. 114: 203-13. PMID 10435998 DOI: 10.1085/jgp.114.2.203  0.652
1999 Koster JC, Sha Q, Shyng S, Nichols CG. ATP inhibition of KATP channels: control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit. The Journal of Physiology. 515: 19-30. PMID 9925874 DOI: 10.1111/J.1469-7793.1999.019Ad.X  0.778
1999 Pearson WL, Dourado M, Schreiber M, Salkoff L, Nichols CG. Expression of a functional Kir4 family inward rectifier K+ channel from a gene cloned from mouse liver. The Journal of Physiology. 514: 639-53. PMID 9882736 DOI: 10.1111/J.1469-7793.1999.639Ad.X  0.6
1999 Nichols CG, Lopatin AN. Chapter 10 Inwardly Rectifying Potassium Channels: Mechanisms of Rectification Current Topics in Membranes and Transport. 46: 159-176. DOI: 10.1016/S0070-2161(08)60926-0  0.537
1999 Koster JC, Sha Q, Shyng SL, Nichols CG. ATP inhibition of K(ATP) channels: Control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit Journal of Physiology. 515: 19-30.  0.71
1998 Shyng SL, Nichols CG. Membrane phospholipid control of nucleotide sensitivity of KATP channels. Science (New York, N.Y.). 282: 1138-41. PMID 9804554 DOI: 10.1126/Science.282.5391.1138  0.792
1998 Lopatin AN, Makhina EN, Nichols CG. Novel tools for localizing ion channels in living cells. Trends in Pharmacological Sciences. 19: 395-8. PMID 9803827 DOI: 10.1016/S0165-6147(98)01238-3  0.557
1998 Pearson WL, Nichols CG. Block of the Kir2.1 channel pore by alkylamine analogues of endogenous polyamines. The Journal of General Physiology. 112: 351-63. PMID 9725894 DOI: 10.1085/jgp.112.3.351  0.513
1998 Shyng SL, Ferrigni T, Shepard JB, Nestorowicz A, Glaser B, Permutt MA, Nichols CG. Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy. Diabetes. 47: 1145-51. PMID 9648840 DOI: 10.2337/diabetes.47.7.1145  0.8
1998 Nestorowicz A, Glaser B, Wilson BA, Shyng SL, Nichols CG, Stanley CA, Thornton PS, Permutt MA. Genetic heterogeneity in familial hyperinsulinism. Human Molecular Genetics. 7: 1119-28. PMID 9618169 DOI: 10.1093/hmg/7.7.1119  0.603
1998 Minor NT, Sha Q, Nichols CG, Mercer RW. The gamma subunit of the Na,K-ATPase induces cation channel activity. Proceedings of the National Academy of Sciences of the United States of America. 95: 6521-5. PMID 9600999 DOI: 10.1073/Pnas.95.11.6521  0.417
1998 Lopatin AN, Makhina EN, Nichols CG. A novel crystallization method for visualizing the membrane localization of potassium channels. Biophysical Journal. 74: 2159-70. PMID 9591643 DOI: 10.1016/S0006-3495(98)77925-1  0.592
1998 Koster JC, Bentle KA, Nichols CG, Ho K. Assembly of ROMK1 (Kir 1.1a) inward rectifier K+ channel subunits involves multiple interaction sites. Biophysical Journal. 74: 1821-9. PMID 9545044 DOI: 10.1016/S0006-3495(98)77892-0  0.403
1998 Makhina EN, Nichols CG. Independent trafficking of K(ATP) channel subunits to the plasma membrane Journal of Biological Chemistry. 273: 3369-3374. DOI: 10.1074/jbc.273.6.3369  0.461
1997 Shyng S, Nichols CG. Octameric stoichiometry of the KATP channel complex. The Journal of General Physiology. 110: 655-64. PMID 9382894 DOI: 10.1085/jgp.110.6.655  0.799
1997 Shyng S, Ferrigni T, Nichols CG. Regulation of KATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor. The Journal of General Physiology. 110: 643-54. PMID 9382893 DOI: 10.1085/jgp.110.6.643  0.792
1997 Shyng S, Ferrigni T, Nichols CG. Control of rectification and gating of cloned KATP channels by the Kir6.2 subunit. The Journal of General Physiology. 110: 141-53. PMID 9236207 DOI: 10.1085/jgp.110.2.141  0.804
1997 Nichols CG, Lopatin AN. Inward rectifier potassium channels. Annual Review of Physiology. 59: 171-91. PMID 9074760 DOI: 10.1146/Annurev.Physiol.59.1.171  0.663
1996 Cohen NA, Sha Q, Makhina EN, Lopatin AN, Linder ME, Snyder SH, Nichols CG. Inhibition of an inward rectifier potassium channel (Kir2.3) by G-protein betagamma subunits. The Journal of Biological Chemistry. 271: 32301-5. PMID 8943291 DOI: 10.1074/Jbc.271.50.32301  0.485
1996 Henry P, Pearson WL, Nichols CG. Protein kinase C inhibition of cloned inward rectifier (HRK1/KIR2.3) K+ channels expressed in Xenopus oocytes. The Journal of Physiology. 495: 681-8. PMID 8887775 DOI: 10.1113/Jphysiol.1996.Sp021625  0.51
1996 Shyng SL, Sha Q, Ferrigni T, Lopatin AN, Nichols CG. Depletion of intracellular polyamines relieves inward rectification of potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 93: 12014-9. PMID 8876254 DOI: 10.1073/Pnas.93.21.12014  0.722
1996 Lopatin AN, Nichols CG. [K+] dependence of polyamine-induced rectification in inward rectifier potassium channels (IRK1, Kir2.1). The Journal of General Physiology. 108: 105-13. PMID 8854340 DOI: 10.1085/Jgp.108.2.105  0.459
1996 Lopatin AN, Nichols CG. [K+] dependence of open-channel conductance in cloned inward rectifier potassium channels (IRK1, Kir2.1). Biophysical Journal. 71: 682-94. PMID 8842207 DOI: 10.1016/S0006-3495(96)79268-8  0.581
1996 Nichols CG, Shyng SL, Nestorowicz A, Glaser B, Clement JP, Gonzalez G, Aguilar-Bryan L, Permutt MA, Bryan J. Adenosine diphosphate as an intracellular regulator of insulin secretion. Science (New York, N.Y.). 272: 1785-7. PMID 8650576 DOI: 10.1126/Science.272.5269.1785  0.749
1996 Sha Q, Romano C, Lopatin AN, Nichols CG. Spermidine release from xenopus oocytes. Electrodiffusion through a membrane channel. The Journal of Biological Chemistry. 271: 3392-7. PMID 8631938 DOI: 10.1074/Jbc.271.7.3392  0.47
1996 Nichols CG, Makhina EN, Pearson WL, Sha Q, Lopatin AN. Inward rectification and implications for cardiac excitability. Circulation Research. 78: 1-7. PMID 8603491 DOI: 10.1161/01.Res.78.1.1  0.647
1996 Permitt MA, Neftorowicz A, Sohoor K, Wilson BA, Nichols CG, Shyng SL, Qlmer B, Stanley C, Paul S, Biyan TJ, Agullv-Biyan L. Identification of mutations in the sulfonylurea receptor gene associated with fame.ial hyperinsulinism Journal of Investigative Medicine. 44: 314a.  0.537
1995 Lopatin AN, Makhina EN, Nichols CG. The mechanism of inward rectification of potassium channels: "long-pore plugging" by cytoplasmic polyamines. The Journal of General Physiology. 106: 923-55. PMID 8648298 DOI: 10.1085/Jgp.106.5.923  0.539
1995 Aguilar-Bryan L, Nichols CG, Wechsler SW, Clement JP, Boyd AE, González G, Herrera-Sosa H, Nguy K, Bryan J, Nelson DA. Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science (New York, N.Y.). 268: 423-6. PMID 7716547 DOI: 10.1126/Science.7716547  0.438
1995 Ferrer J, Nichols CG, Makhina EN, Salkoff L, Bernstein J, Gerhard D, Wasson J, Ramanadham S, Permutt A. Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels. The Journal of Biological Chemistry. 270: 26086-91. PMID 7592809 DOI: 10.1074/Jbc.270.44.26086  0.559
1994 Lopatin AN, Nichols CG. Internal Na+ and Mg2+ blockade of DRK1 (Kv2.1) potassium channels expressed in Xenopus oocytes. Inward rectification of a delayed rectifier. The Journal of General Physiology. 103: 203-16. PMID 8189205 DOI: 10.1085/jgp.103.2.203  0.492
1994 Baghdady R, Nichols C. ATP sensitive potassium channels and ischemic heart disease. Cardiovascular Research. 28: 135-6. PMID 8147969 DOI: 10.1093/CVR/28.1.135  0.535
1994 Nichols CG, Ho K, Hebert S. Mg(2+)-dependent inward rectification of ROMK1 potassium channels expressed in Xenopus oocytes. The Journal of Physiology. 476: 399-409. PMID 8057249 DOI: 10.1113/Jphysiol.1994.Sp020141  0.557
1994 Makhina EN, Kelly AJ, Lopatin AN, Mercer RW, Nichols CG. Cloning and expression of a novel human brain inward rectifier potassium channel. The Journal of Biological Chemistry. 269: 20468-74. PMID 8051145  0.469
1994 Lopatin AN, Makhina EN, Nichols CG. Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature. 372: 366-9. PMID 7969496 DOI: 10.1038/372366A0  0.62
1994 Nichols CG. Molecular biology of the KATP channel. Where's the clone? Cardiovascular Research. 28: 727-8. PMID 7923270 DOI: 10.1093/cvrese/28.6.727  0.555
1994 Nichols CG, Gross GJ. Introduction to the special issue on ATP sensitive potassium channels Cardiovascular Research. 28: 726-726. DOI: 10.1093/CVR/28.6.726  0.617
1994 Nichols CG. Ion Channels in the cardiovascular system: Function and dysfunction Trends in Pharmacological Sciences. 15: 470-471. DOI: 10.1016/0165-6147(94)90063-9  0.505
1993 Nichols CG, Lopatin AN. Trypsin and alpha-chymotrypsin treatment abolishes glibenclamide sensitivity of KATP channels in rat ventricular myocytes. Pflã¼Gers Archiv : European Journal of Physiology. 422: 617-9. PMID 8469613 DOI: 10.1007/Bf00374011  0.628
1993 Rajan AS, Aguilar-Bryan L, Nelson DA, Nichols CG, Wechsler SW, Lechago J, Bryan J. Sulfonylurea receptors and ATP-sensitive K+ channels in clonal pancreatic alpha cells. Evidence for two high affinity sulfonylurea receptors. The Journal of Biological Chemistry. 268: 15221-8. PMID 8325894  0.348
1993 Ripoll C, Lederer WJ, Nichols CG. On the mechanism of inhibition of KATP channels by glibenclamide in rat ventricular myocytes. Journal of Cardiovascular Electrophysiology. 4: 38-47. PMID 8287235 DOI: 10.1111/J.1540-8167.1993.Tb01210.X  0.697
1993 Nichols CG. The 'inner core' of inwardly rectifying K+ channels. Trends in Pharmacological Sciences. 14: 320-3. PMID 8249152 DOI: 10.1016/0165-6147(93)90003-3  0.579
1993 Ho K, Nichols CG, Lederer WJ, Lytton J, Vassilev PM, Kanazirska MV, Hebert SC. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature. 362: 31-8. PMID 7680431 DOI: 10.1038/362031a0  0.691
1993 Nichols CG. Ion channels — 3 Trends in Neurosciences. 16: 337. DOI: 10.1016/0166-2236(93)90114-2  0.521
1992 COHEN NM, LEDERER W, NICHOLS CG. Activation of ATP-Sensitive Potassium Channels Underlies Contractile Failure in Single Human Cardiac Myocytes During Complete Metabolic Inhibition Journal of Cardiovascular Electrophysiology. 3: 56-63. DOI: 10.1111/j.1540-8167.1992.tb01096.x  0.586
1992 Aguilar-Bryan L, Nichols C, Rajan A, Parker C, Bryan J. Co-expression of sulfonylurea receptors and KATP channels in hamster insulinoma tumor (HIT) cells. Evidence for direct association of the receptor with the channel. Journal of Biological Chemistry. 267: 14934-14940. DOI: 10.1016/s0021-9258(18)42130-8  0.43
1991 Nichols CG, Ripoll C, Lederer WJ. ATP-sensitive potassium channel modulation of the guinea pig ventricular action potential and contraction. Circulation Research. 68: 280-7. PMID 1984868 DOI: 10.1161/01.Res.68.1.280  0.645
1991 Nichols CG, Lederer WJ. The mechanism of KATP channel inhibition by ATP. The Journal of General Physiology. 97: 1095-8. PMID 1865175 DOI: 10.1085/Jgp.97.5.1095  0.677
1991 Nichols CG, Lederer WJ, Cannell MB. ATP dependence of KATP channel kinetics in isolated membrane patches from rat ventricle. Biophysical Journal. 60: 1164-77. PMID 1760506 DOI: 10.1016/S0006-3495(91)82152-X  0.666
1991 Nichols CG, Lederer WJ. Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. The American Journal of Physiology. 261: H1675-86. PMID 1750525 DOI: 10.1152/Ajpheart.1991.261.6.H1675  0.68
1991 Cannell MB, Nichols CG. Effects of pipette geometry on the time course of solution change in patch clamp experiments. Biophysical Journal. 60: 1156-63. PMID 1722116 DOI: 10.1016/S0006-3495(91)82151-8  0.411
1990 Nichols CG, Lederer WJ. The regulation of ATP-sensitive K+ channel activity in intact and permeabilized rat ventricular myocytes. The Journal of Physiology. 423: 91-110. PMID 2388163 DOI: 10.1113/Jphysiol.1990.Sp018013  0.667
1990 Nichols CG, Niggli E, Lederer WJ. Modulation of ATP-sensitive potassium channel activity by flash-photolysis of 'caged-ATP' in rat heart cells. Pflã¼Gers Archiv : European Journal of Physiology. 415: 510-2. PMID 2315010 DOI: 10.1007/Bf00373635  0.643
1990 Nichols CG, Lederer WJ. The role of ATP in energy-deprivation contractures in unloaded rat ventricular myocytes. Canadian Journal of Physiology and Pharmacology. 68: 183-94. PMID 2311000 DOI: 10.1139/Y90-029  0.439
1990 Ripoll C, Lederer WJ, Nichols CG. Modulation of ATP-sensitive K+ channel activity and contractile behavior in mammalian ventricle by the potassium channel openers cromakalim and RP49356. The Journal of Pharmacology and Experimental Therapeutics. 255: 429-35. PMID 2243335  0.628
1989 Lederer WJ, Nichols CG. Nucleotide modulation of the activity of rat heart ATP-sensitive K+ channels in isolated membrane patches. The Journal of Physiology. 419: 193-211. PMID 2621629 DOI: 10.1113/Jphysiol.1989.Sp017869  0.671
1989 Lederer WJ, Nichols CG, Smith GL. The mechanism of early contractile failure of isolated rat ventricular myocytes subjected to complete metabolic inhibition. The Journal of Physiology. 413: 329-49. PMID 2600854 DOI: 10.1113/Jphysiol.1989.Sp017657  0.487
1989 Nichols CG, Hanck DA, Jewell BR. Erratum: The Anrep effect: an intrinsic myocardial mechanism Canadian Journal of Physiology and Pharmacology. 67: 172-172. DOI: 10.1139/Y89-029  0.593
1988 Stern MD, Silverman HS, Houser SR, Josephson RA, Capogrossi MC, Nichols CG, Lederer WJ, Lakatta EG. Anoxic contractile failure in rat heart myocytes is caused by failure of intracellular calcium release due to alteration of the action potential. Proceedings of the National Academy of Sciences of the United States of America. 85: 6954-8. PMID 3413129  0.335
1988 Nichols CG, Hanck DA, Jewell BR. The Anrep effect: an intrinsic myocardial mechanism. Canadian Journal of Physiology and Pharmacology. 66: 924-9. PMID 3214805 DOI: 10.1139/Y88-150  0.608
1985 NICHOLS CG, ROUSE W, JEWELL BR. Length-dependence of activation in isolated cardiac muscle and in the whole heart Cardiovascular Research. 19: 522-522. DOI: 10.1093/CVR/19.9.522  0.606
Show low-probability matches.