Justin Nickell - Publications

Affiliations: 
University of Kentucky, Lexington, KY 

20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Nickell JR, Culver JP, Janganati V, Zheng G, Dwoskin LP, Crooks PA. Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. PMID 27524311 DOI: 10.1016/j.bmcl.2016.08.001  0.64
2016 Nickell JR, Culver JP, Janganati V, Zheng G, Dwoskin LP, Crooks PA. 1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. PMID 27212067 DOI: 10.1016/j.bmcl.2016.05.025  0.64
2016 Joolakanti SR, Nickell JR, Janganati V, Zheng G, Dwoskin LP, Crooks PA. Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. PMID 27080180 DOI: 10.1016/j.bmcl.2016.03.119  0.64
2015 Sviripa VM, Burikhanov R, Obiero JM, Yuan Y, Nickell JR, Dwoskin LP, Zhan CG, Liu C, Tsodikov OV, Rangnekar VM, Watt DS. Par-4 secretion: stoichiometry of 3-arylquinoline binding to vimentin. Organic & Biomolecular Chemistry. PMID 26548370 DOI: 10.1039/c5ob01980j  0.64
2015 Ding D, Nickell JR, Dwoskin LP, Crooks PA. Quinolyl analogues of norlobelane: Novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. 25: 2613-6. PMID 25991431 DOI: 10.1016/j.bmcl.2015.04.105  0.64
2014 Sviripa VM, Zhang W, Balia AG, Tsodikov OV, Nickell JR, Gizard F, Yu T, Lee EY, Dwoskin LP, Liu C, Watt DS. 2',6'-Dihalostyrylanilines, pyridines, and pyrimidines for the inhibition of the catalytic subunit of methionine S-adenosyltransferase-2. Journal of Medicinal Chemistry. 57: 6083-91. PMID 24950374 DOI: 10.1021/jm5004864  0.64
2014 Nickell JR, Siripurapu KB, Vartak A, Crooks PA, Dwoskin LP. The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse. Advances in Pharmacology (San Diego, Calif.). 69: 71-106. PMID 24484975 DOI: 10.1016/B978-0-12-420118-7.00002-0  0.64
2013 Ding D, Nickell JR, Deaciuc AG, Penthala NR, Dwoskin LP, Crooks PA. Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake. Bioorganic & Medicinal Chemistry. 21: 6771-7. PMID 23993667 DOI: 10.1016/j.bmc.2013.08.001  0.64
2013 Horton DB, Nickell JR, Zheng G, Crooks PA, Dwoskin LP. GZ-793A, a lobelane analog, interacts with the vesicular monoamine transporter-2 to inhibit the effect of methamphetamine. Journal of Neurochemistry. 127: 177-86. PMID 23875622 DOI: 10.1111/jnc.12371  0.64
2013 Nickell JR, Grinevich VP, Siripurapu KB, Smith AM, Dwoskin LP. Potential therapeutic uses of mecamylamine and its stereoisomers. Pharmacology, Biochemistry, and Behavior. 108: 28-43. PMID 23603417 DOI: 10.1016/j.pbb.2013.04.005  0.64
2013 Penthala NR, Ponugoti PR, Nickell JR, Deaciuc AG, Dwoskin LP, Crooks PA. Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2). Bioorganic & Medicinal Chemistry Letters. 23: 3342-5. PMID 23597792 DOI: 10.1016/j.bmcl.2013.03.092  0.64
2013 Zheng G, Horton DB, Penthala NR, Nickell JR, Culver JP, Deaciuc AG, Dwoskin LP, Crooks PA. Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse. Medchemcomm. 4: 564-568. PMID 23527317 DOI: 10.1039/C3MD20374C  0.64
2011 Meyer AC, Horton DB, Neugebauer NM, Wooters TE, Nickell JR, Dwoskin LP, Bardo MT. Tetrabenazine inhibition of monoamine uptake and methamphetamine behavioral effects: locomotor activity, drug discrimination and self-administration. Neuropharmacology. 61: 849-56. PMID 21669212 DOI: 10.1016/j.neuropharm.2011.05.033  0.64
2011 Nickell JR, Zheng G, Deaciuc AG, Crooks PA, Dwoskin LP. Phenyl ring-substituted lobelane analogs: inhibition of [³H]dopamine uptake at the vesicular monoamine transporter-2. The Journal of Pharmacology and Experimental Therapeutics. 336: 724-33. PMID 20876747 DOI: 10.1124/jpet.110.172882  0.64
2010 Beckmann JS, Siripurapu KB, Nickell JR, Horton DB, Denehy ED, Vartak A, Crooks PA, Dwoskin LP, Bardo MT. The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats. The Journal of Pharmacology and Experimental Therapeutics. 335: 841-51. PMID 20805303 DOI: 10.1124/jpet.110.172742  0.64
2010 Nickell JR, Krishnamurthy S, Norrholm S, Deaciuc G, Siripurapu KB, Zheng G, Crooks PA, Dwoskin LP. Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2. The Journal of Pharmacology and Experimental Therapeutics. 332: 612-21. PMID 19855096 DOI: 10.1124/jpet.109.160275  0.64
2009 Vartak AP, Nickell JR, Chagkutip J, Dwoskin LP, Crooks PA. Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2). Journal of Medicinal Chemistry. 52: 7878-82. PMID 19691331 DOI: 10.1021/jm900770h  0.64
2008 Stephens ML, Spencer DD, Cavus I, Hsiao MC, Song D, Deadwyler SA, Hampson RE, Putz D, Quintero JE, Bensalem-Owen MK, Hascup KN, Rutherford EC, Day BK, Nickell JR, Pomerleau F, et al. Microelectrode-Based Epilepsy Therapy: A Hybrid Neural Prosthesis Incorporating Seizure Prediction and Intervention with Biomimetic Maintenance of Normal Hippocampal Function Computational Neuroscience in Epilepsy. 559-586. DOI: 10.1016/B978-012373649-9.50036-3  0.64
2007 Nickell J, Salvatore MF, Pomerleau F, Apparsundaram S, Gerhardt GA. Reduced plasma membrane surface expression of GLAST mediates decreased glutamate regulation in the aged striatum. Neurobiology of Aging. 28: 1737-48. PMID 16959378 DOI: 10.1016/j.neurobiolaging.2006.07.015  0.64
2005 Nickell J, Pomerleau F, Allen J, Gerhardt GA. Age-related changes in the dynamics of potassium-evoked L-glutamate release in the striatum of Fischer 344 rats. Journal of Neural Transmission (Vienna, Austria : 1996). 112: 87-96. PMID 15599607 DOI: 10.1007/s00702-004-0151-x  0.64
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