Bertil B. Fredholm, PhD - Publications

Affiliations: 
Karolinska Institute, Stockholm, Sweden 
Area:
Adenosine receptors
Website:
http://ki.se/ki/jsp/polopoly.jsp?d=33393&l=en

311 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Lazarus M, Chen JF, Huang ZL, Urade Y, Fredholm BB. Adenosine and Sleep. Handbook of Experimental Pharmacology. PMID 28646346 DOI: 10.1007/164_2017_36  0.52
2015 Winerdal M, Winerdal ME, Wang YQ, Fredholm BB, Winqvist O, Ådén U. Adenosine A1 receptors contribute to immune regulation after neonatal hypoxic ischemic brain injury. Purinergic Signalling. PMID 26608888 DOI: 10.1007/s11302-015-9482-3  1
2015 Peleli M, Hezel M, Zollbrecht C, Persson AE, Lundberg JO, Weitzberg E, Fredholm BB, Carlström M. In adenosine A2B knockouts acute treatment with inorganic nitrate improves glucose disposal, oxidative stress, and AMPK signaling in the liver. Frontiers in Physiology. 6: 222. PMID 26300787 DOI: 10.3389/fphys.2015.00222  1
2015 Yang T, Gao X, Sandberg M, Zollbrecht C, Zhang XM, Hezel M, Liu M, Peleli M, Lai EY, Harris RA, Persson AE, Fredholm BB, Jansson L, Carlström M. Abrogation of adenosine A1 receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses. Diabetologia. 58: 1610-20. PMID 25835725 DOI: 10.1007/s00125-015-3570-3  1
2014 Fredholm BB. Adenosine--a physiological or pathophysiological agent? Journal of Molecular Medicine (Berlin, Germany). 92: 201-6. PMID 24362516 DOI: 10.1007/s00109-013-1101-6  0.4
2014 Yang J, Zheng X, Haugen F, Darè E, Lövdahl C, Schulte G, Fredholm BB, Valen G. Adenosine increases LPS-induced nuclear factor kappa B activation in smooth muscle cells via an intracellular mechanism and modulates it via actions on adenosine receptors. Acta Physiologica (Oxford, England). 210: 590-9. PMID 24119187 DOI: 10.1111/apha.12176  0.4
2014 Sällström J, Eriksson T, Fredholm BB, Persson AE, Palm F. Inhibition of sodium-linked glucose reabsorption normalizes diabetes-induced glomerular hyperfiltration in conscious adenosine A₁-receptor deficient mice. Acta Physiologica (Oxford, England). 210: 440-5. PMID 23901799 DOI: 10.1111/apha.12152  0.4
2014 Fredholm BB. Adenosine Receptors as the Biochemical Target for Low Doses of Caffeine Coffee in Health and Disease Prevention. 831-834. DOI: 10.1016/B978-0-12-409517-5.00091-7  1
2013 Chen JF, Eltzschig HK, Fredholm BB. Adenosine receptors as drug targets--what are the challenges? Nature Reviews. Drug Discovery. 12: 265-86. PMID 23535933 DOI: 10.1038/nrd3955  0.4
2013 Fredholm BB. Adenosine and metabolism-A brief historical note Adenosine: a Key Link Between Metabolism and Brain Activity. 3-19. DOI: 10.1007/978-1-4614-3903-5_1  1
2012 Fredholm BB. [The Nobel Prize to detailed studies of G protein-coupled receptors. This years Nobel Prize in chemistry provides important knowledge--but it might take a while before it can be practically applied]. LäKartidningen. 109: 2274-5. PMID 23367861  1
2012 Yang GK, Fredholm BB, Kieffer TJ, Kwok YN. Improved blood glucose disposal and altered insulin secretion patterns in adenosine A(1) receptor knockout mice. American Journal of Physiology. Endocrinology and Metabolism. 303: E180-90. PMID 22550063 DOI: 10.1152/ajpendo.00050.2012  0.4
2012 Fredholm BB. Rethinking the purinergic neuron-glia connection. Proceedings of the National Academy of Sciences of the United States of America. 109: 5913-4. PMID 22509008 DOI: 10.1073/pnas.1203764109  1
2012 Fredholm BB. How drugs can stimulate psychic functions - Using caffeine as an example European Review. 20: 316-323. DOI: 10.1017/S1062798711000573  0.4
2011 Cipriani R, Villa P, Chece G, Lauro C, Paladini A, Micotti E, Perego C, De Simoni MG, Fredholm BB, Eusebi F, Limatola C. CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 16327-35. PMID 22072684 DOI: 10.1523/JNEUROSCI.3611-11.2011  0.4
2011 Gao X, Patzak A, Sendeski M, Scheffer PG, Teerlink T, Sällström J, Fredholm BB, Persson AE, Carlström M. Adenosine A₁-receptor deficiency diminishes afferent arteriolar and blood pressure responses during nitric oxide inhibition and angiotensin II treatment. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 301: R1669-81. PMID 21975649 DOI: 10.1152/ajpregu.00268.2011  0.4
2011 Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass CE, Winsky-Sommerer R, Semba K, Fredholm BB, Boison D, Hayaishi O, Urade Y, Chen JF. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10067-75. PMID 21734299 DOI: 10.1523/JNEUROSCI.6730-10.2011  0.4
2011 Masino SA, Li T, Theofilas P, Sandau US, Ruskin DN, Fredholm BB, Geiger JD, Aronica E, Boison D. A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors. The Journal of Clinical Investigation. 121: 2679-83. PMID 21701065 DOI: 10.1172/JCI57813  0.4
2011 Fredholm BB, Johansson S, Wang YQ. Adenosine and the regulation of metabolism and body temperature. Advances in Pharmacology (San Diego, Calif.). 61: 77-94. PMID 21586356 DOI: 10.1016/B978-0-12-385526-8.00003-5  0.4
2011 Burnstock G, Fredholm BB, Verkhratsky A. Adenosine and ATP receptors in the brain. Current Topics in Medicinal Chemistry. 11: 973-1011. PMID 21401499 DOI: 10.2174/156802611795347627  0.4
2011 Fredholm BB, IJzerman AP, Jacobson KA, Linden J, Müller CE. International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update. Pharmacological Reviews. 63: 1-34. PMID 21303899 DOI: 10.1124/pr.110.003285  0.4
2011 Figler RA, Wang G, Srinivasan S, Jung DY, Zhang Z, Pankow JS, Ravid K, Fredholm B, Hedrick CC, Rich SS, Kim JK, LaNoue KF, Linden J. Links between Insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans Diabetes. 60: 669-679. PMID 21270276 DOI: 10.2337/db10-1070  0.4
2011 Yang GK, Yip L, Fredholm BB, Kieffer TJ, Kwok YN. Involvement of adenosine signaling in controlling the release of ghrelin from the mouse stomach. The Journal of Pharmacology and Experimental Therapeutics. 336: 77-86. PMID 20876230 DOI: 10.1124/jpet.110.171280  0.4
2011 Fredholm BB. Notes on the history of caffeine use. Handbook of Experimental Pharmacology. 1-9. PMID 20859791 DOI: 10.1007/978-3-642-13443-2_1  0.4
2011 Xiao D, Cassin JJ, Healy B, Burdett TC, Chen JF, Fredholm BB, Schwarzschild MA. Deletion of adenosine A₁ or A(â‚‚A) receptors reduces L-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson's disease. Brain Research. 1367: 310-8. PMID 20828543 DOI: 10.1016/j.brainres.2010.08.099  0.4
2011 Fredholm BB. Physiological and pathophysiological roles of adenosine Sleep and Biological Rhythms. 9: 24-28. DOI: 10.1111/j.1479-8425.2010.00460.x  0.4
2010 Fredholm BB, Nordén B. Fuels for transportation. Ambio. 39: 31-5. PMID 20873684 DOI: 10.1007/s13280-010-0062-z  0.4
2010 Kenakin T, Agnati LF, Caron M, Fredholm B, Guidoli D, Kobilka B, Lefkowitz RW, Lohse M, Woods A, Fuxe K. International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached? Journal of Receptor and Signal Transduction Research. 30: 284-6. PMID 20858022 DOI: 10.3109/10799893.2010.512438  0.4
2010 Sällström J, Carlström M, Olerud J, Fredholm BB, Kouzmine M, Sandler S, Persson AE. High-protein-induced glomerular hyperfiltration is independent of the tubuloglomerular feedback mechanism and nitric oxide synthases. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 299: R1263-8. PMID 20739607 DOI: 10.1152/ajpregu.00649.2009  0.4
2010 Li L, Hao JX, Fredholm BB, Schulte G, Wiesenfeld-Hallin Z, Xu XJ. Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice. Neuroscience. 170: 923-8. PMID 20678550 DOI: 10.1016/j.neuroscience.2010.07.045  0.4
2010 Piccinin S, Di Angelantonio S, Piccioni A, Volpini R, Cristalli G, Fredholm BB, Limatola C, Eusebi F, Ragozzino D. CX3CL1-induced modulation at CA1 synapses reveals multiple mechanisms of EPSC modulation involving adenosine receptor subtypes. Journal of Neuroimmunology. 224: 85-92. PMID 20570369 DOI: 10.1016/j.jneuroim.2010.05.012  0.4
2010 Fredholm B, Verkhratsky A. Purines - 80 years and very much alive Acta Physiologica. 199: 91-92. PMID 20534039 DOI: 10.1111/j.1748-1716.2010.02113.x  1
2010 Burnstock G, Fredholm BB, North RA, Verkhratsky A. The birth and postnatal development of purinergic signalling. Acta Physiologica (Oxford, England). 199: 93-147. PMID 20345419 DOI: 10.1111/j.1748-1716.2010.02114.x  1
2010 Lauro C, Cipriani R, Catalano M, Trettel F, Chece G, Brusadin V, Antonilli L, van Rooijen N, Eusebi F, Fredholm BB, Limatola C. Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1550-9. PMID 20200508 DOI: 10.1038/npp.2010.26  0.4
2010 Kara FM, Chitu V, Sloane J, Axelrod M, Fredholm BB, Stanley ER, Cronstein BN. Adenosine A1 receptors (A1Rs) play a critical role in osteoclast formation and function. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2325-33. PMID 20181934 DOI: 10.1096/fj.09-147447  0.4
2010 Sawynok J, Reid AR, Fredholm BB. Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A1 receptors: insights using knockout mice. Neuroscience Letters. 473: 178-81. PMID 20176083 DOI: 10.1016/j.neulet.2010.02.028  0.4
2010 Fredholm BB. Adenosine receptors as drug targets. Experimental Cell Research. 316: 1284-8. PMID 20153317 DOI: 10.1016/j.yexcr.2010.02.004  0.4
2010 Wang Y, Yang JN, Arner A, Boels PJ, Fredholm BB. Adenosine A(1) receptors and vascular reactivity. Acta Physiologica (Oxford, England). 199: 211-20. PMID 20132147 DOI: 10.1111/j.1748-1716.2010.02093.x  1
2010 Yang JN, Wang Y, Garcia-Roves PM, Björnholm M, Fredholm BB. Adenosine A(3) receptors regulate heart rate, motor activity and body temperature. Acta Physiologica (Oxford, England). 199: 221-30. PMID 20121716 DOI: 10.1111/j.1748-1716.2010.02091.x  1
2010 Kara FM, Doty SB, Boskey A, Goldring S, Zaidi M, Fredholm BB, Cronstein BN. Adenosine A(1) receptors regulate bone resorption in mice: adenosine A(1) receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A(1) receptor-knockout mice. Arthritis and Rheumatism. 62: 534-41. PMID 20112380 DOI: 10.1002/art.27219  0.4
2010 Boison D, Chen JF, Fredholm BB. Adenosine signaling and function in glial cells. Cell Death and Differentiation. 17: 1071-82. PMID 19763139 DOI: 10.1038/cdd.2009.131  0.4
2009 Maggi L, Trettel F, Scianni M, Bertollini C, Eusebi F, Fredholm BB, Limatola C. LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R). Journal of Neuroimmunology. 215: 36-42. PMID 19709758 DOI: 10.1016/j.jneuroim.2009.07.016  1
2009 Salehi A, Parandeh F, Fredholm BB, Grapengiesser E, Hellman B. Absence of adenosine A1 receptors unmasks pulses of insulin release and prolongs those of glucagon and somatostatin. Life Sciences. 85: 470-6. PMID 19682463 DOI: 10.1016/j.lfs.2009.08.001  1
2009 Jenner P, Mori A, Hauser R, Morelli M, Fredholm BB, Chen JF. Adenosine, adenosine A 2A antagonists, and Parkinson's disease. Parkinsonism & Related Disorders. 15: 406-13. PMID 19446490 DOI: 10.1016/j.parkreldis.2008.12.006  1
2009 Yu L, Coelho JE, Zhang X, Fu Y, Tillman A, Karaoz U, Fredholm BB, Weng Z, Chen JF. Uncovering multiple molecular targets for caffeine using a drug target validation strategy combining A 2A receptor knockout mice with microarray profiling. Physiological Genomics. 37: 199-210. PMID 19258493 DOI: 10.1152/physiolgenomics.90353.2008  1
2009 Conte C, Grottelli S, Prudenzi E, Bellezza I, Fredholm BB, Minelli A. A(1) and A(3) adenosine receptors alter glutathione status in an organ-specific manner and influence the changes after inhibition of gamma-glutamylcysteine ligase. Free Radical Research. 43: 304-11. PMID 19229670 DOI: 10.1080/10715760802712616  1
2009 Yang JN, Chen JF, Fredholm BB. Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine. American Journal of Physiology. Heart and Circulatory Physiology. 296: H1141-9. PMID 19218506 DOI: 10.1152/ajpheart.00754.2008  1
2009 Yang JN, Björklund O, Lindström-Törnqvist K, Lindgren E, Eriksson TM, Kahlström J, Chen JF, Schwarzschild MA, Tobler I, Fredholm BB. Mice heterozygous for both A1 and A(2A) adenosine receptor genes show similarities to mice given long-term caffeine. Journal of Applied Physiology (Bethesda, Md. : 1985). 106: 631-9. PMID 19036889 DOI: 10.1152/japplphysiol.90971.2008  1
2009 Fredholm BB, Jacobson KA. Adenosine receptors: The contributions by John W. Daly Heterocycles. 79: 73-83. DOI: 10.3987/COM-08-S(D)Memoire-2  1
2008 Björklund O, Kahlström J, Salmi P, Fredholm BB. Perinatal caffeine, acting on maternal adenosine A(1) receptors, causes long-lasting behavioral changes in mouse offspring. Plos One. 3: e3977. PMID 19092996 DOI: 10.1371/journal.pone.0003977  1
2008 Oishi Y, Huang ZL, Fredholm BB, Urade Y, Hayaishi O. Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep. Proceedings of the National Academy of Sciences of the United States of America. 105: 19992-7. PMID 19066225 DOI: 10.1073/pnas.0810926105  1
2008 Björklund O, Halldner-Henriksson L, Yang J, Eriksson TM, Jacobson MA, Daré E, Fredholm BB. Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice. Physiology & Behavior. 95: 668-76. PMID 18930070 DOI: 10.1016/j.physbeh.2008.09.018  1
2008 Roseti C, Martinello K, Fucile S, Piccari V, Mascia A, Di Gennaro G, Quarato PP, Manfredi M, Esposito V, Cantore G, Arcella A, Simonato M, Fredholm BB, Limatola C, Miledi R, et al. Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors. Proceedings of the National Academy of Sciences of the United States of America. 105: 15118-23. PMID 18809912 DOI: 10.1073/pnas.0807277105  1
2008 Johansson SM, Lindgren E, Yang JN, Herling AW, Fredholm BB. Adenosine A1 receptors regulate lipolysis and lipogenesis in mouse adipose tissue-interactions with insulin. European Journal of Pharmacology. 597: 92-101. PMID 18789919 DOI: 10.1016/j.ejphar.2008.08.022  1
2008 Björklund O, Shang M, Tonazzini I, Daré E, Fredholm BB. Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage. European Journal of Pharmacology. 596: 6-13. PMID 18727925 DOI: 10.1016/j.ejphar.2008.08.002  1
2008 Brand F, Klutz AM, Jacobson KA, Fredholm BB, Schulte G. Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC. European Journal of Pharmacology. 590: 36-42. PMID 18603240 DOI: 10.1016/j.ejphar.2008.05.036  1
2008 Sawynok J, Reid AR, Fredholm BB. Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors. Neuroscience Letters. 440: 181-4. PMID 18562097 DOI: 10.1016/j.neulet.2008.05.074  1
2008 Hua X, Chason KD, Fredholm BB, Deshpande DA, Penn RB, Tilley SL. Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells. The Journal of Allergy and Clinical Immunology. 122: 107-13, 113.e1-7. PMID 18472152 DOI: 10.1016/j.jaci.2008.03.026  1
2008 Xia S, Dun XP, Hu PS, Kjaer S, Zheng K, Qian Y, Solén C, Xu T, Fredholm B, Hökfelt T, Xu ZQ. Postendocytotic traffic of the galanin R1 receptor: a lysosomal signal motif on the cytoplasmic terminus. Proceedings of the National Academy of Sciences of the United States of America. 105: 5609-13. PMID 18385373 DOI: 10.1073/pnas.0801456105  1
2008 Chen L, Fredholm BB, Jondal M. Adenosine, through the A1 receptor, inhibits vesicular MHC class I cross-presentation by resting DC. Molecular Immunology. 45: 2247-54. PMID 18178251 DOI: 10.1016/j.molimm.2007.11.016  1
2008 Minelli A, Bellezza I, Collodel G, Fredholm BB. Promiscuous coupling and involvement of protein kinase C and extracellular signal-regulated kinase 1/2 in the adenosine A1 receptor signalling in mammalian spermatozoa. Biochemical Pharmacology. 75: 931-41. PMID 18054348 DOI: 10.1016/j.bcp.2007.10.024  1
2007 Li T, Quan Lan J, Fredholm BB, Simon RP, Boison D. Adenosine dysfunction in astrogliosis: cause for seizure generation? Neuron Glia Biology. 3: 353-66. PMID 18634566 DOI: 10.1017/S1740925X0800015X  1
2007 Ohta A, Lukashev D, Jackson EK, Fredholm BB, Sitkovsky M. 1,3,7-trimethylxanthine (caffeine) may exacerbate acute inflammatory liver injury by weakening the physiological immunosuppressive mechanism. Journal of Immunology (Baltimore, Md. : 1950). 179: 7431-8. PMID 18025187  1
2007 Björklund O, Kahlström J, Salmi P, Ogren SO, Vahter M, Chen JF, Fredholm BB, Daré E. The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administration. Toxicology. 241: 119-33. PMID 17920182 DOI: 10.1016/j.tox.2007.08.092  1
2007 Johansson SM, Salehi A, Sandström ME, Westerblad H, Lundquist I, Carlsson PO, Fredholm BB, Katz A. A1 receptor deficiency causes increased insulin and glucagon secretion in mice. Biochemical Pharmacology. 74: 1628-35. PMID 17869224 DOI: 10.1016/j.bcp.2007.08.006  1
2007 Fredholm BB, Chern Y, Franco R, Sitkovsky M. Aspects of the general biology of adenosine A2A signaling. Progress in Neurobiology. 83: 263-76. PMID 17804147 DOI: 10.1016/j.pneurobio.2007.07.005  1
2007 Sällström J, Carlsson PO, Fredholm BB, Larsson E, Persson AE, Palm F. Diabetes-induced hyperfiltration in adenosine A(1)-receptor deficient mice lacking the tubuloglomerular feedback mechanism. Acta Physiologica (Oxford, England). 190: 253-9. PMID 17581137 DOI: 10.1111/j.1748-1716.2007.01705.x  1
2007 Daré E, Schulte G, Karovic O, Hammarberg C, Fredholm BB. Modulation of glial cell functions by adenosine receptors. Physiology & Behavior. 92: 15-20. PMID 17574632 DOI: 10.1016/j.physbeh.2007.05.031  1
2007 Wendler CC, Amatya S, McClaskey C, Ghatpande S, Fredholm BB, Rivkees SA. A1 adenosine receptors play an essential role in protecting the embryo against hypoxia. Proceedings of the National Academy of Sciences of the United States of America. 104: 9697-702. PMID 17522253 DOI: 10.1073/pnas.0703557104  1
2007 Johansson SM, Yang JN, Lindgren E, Fredholm BB. Eliminating the antilipolytic adenosine A1 receptor does not lead to compensatory changes in the antilipolytic actions of PGE2 and nicotinic acid. Acta Physiologica (Oxford, England). 190: 87-96. PMID 17428236 DOI: 10.1111/j.1365-201X.2007.01692.x  1
2007 Yang JN, Tiselius C, Daré E, Johansson B, Valen G, Fredholm BB. Sex differences in mouse heart rate and body temperature and in their regulation by adenosine A1 receptors. Acta Physiologica (Oxford, England). 190: 63-75. PMID 17428234 DOI: 10.1111/j.1365-201X.2007.01690.x  1
2007 Fredholm BB, Hökfelt T, Milligan G. G-protein-coupled receptors: an update. Acta Physiologica (Oxford, England). 190: 3-7. PMID 17428227 DOI: 10.1111/j.1365-201X.2007.01689.x  1
2007 Schulte G, Fredholm B. A Nordic meeting on G-protein-coupled receptors: From molecular aspects to novel therapy Acta Physiologica. 190: 1. PMID 17428226 DOI: 10.1111/j.1365-201X.2007.01686.x  1
2007 Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death and Differentiation. 14: 1315-23. PMID 17396131 DOI: 10.1038/sj.cdd.4402132  1
2007 Tabata T, Kawakami D, Hashimoto K, Kassai H, Yoshida T, Hashimotodani Y, Fredholm BB, Sekino Y, Aiba A, Kano M. G protein-independent neuromodulatory action of adenosine on metabotropic glutamate signalling in mouse cerebellar Purkinje cells. The Journal of Physiology. 581: 693-708. PMID 17379632 DOI: 10.1113/jphysiol.2007.129866  1
2007 Karovic O, Tonazzini I, Rebola N, Edström E, Lövdahl C, Fredholm BB, Daré E. Toxic effects of cobalt in primary cultures of mouse astrocytes. Similarities with hypoxia and role of HIF-1alpha. Biochemical Pharmacology. 73: 694-708. PMID 17169330 DOI: 10.1016/j.bcp.2006.11.008  1
2007 Chergui K, Fredholm BB, Svenningsson P. Many ways to Rome - multiple approaches to novel drugs Current Opinion in Pharmacology. 7: 1-2. DOI: 10.1016/j.coph.2006.12.002  1
2006 Lai EY, Patzak A, Steege A, Mrowka R, Brown R, Spielmann N, Persson PB, Fredholm BB, Persson AE. Contribution of adenosine receptors in the control of arteriolar tone and adenosine-angiotensin II interaction. Kidney International. 70: 690-8. PMID 16807541 DOI: 10.1038/sj.ki.5001650  1
2006 Fedele DE, Li T, Lan JQ, Fredholm BB, Boison D. Adenosine A1 receptors are crucial in keeping an epileptic focus localized. Experimental Neurology. 200: 184-90. PMID 16750195 DOI: 10.1016/j.expneurol.2006.02.133  1
2006 Schotanus SM, Fredholm BB, Chergui K. NMDA depresses glutamatergic synaptic transmission in the striatum through the activation of adenosine A1 receptors: evidence from knockout mice. Neuropharmacology. 51: 272-82. PMID 16712880 DOI: 10.1016/j.neuropharm.2006.03.025  1
2006 Wu WP, Hao JX, Fredholm BB, Wiesenfeld-Hallin Z, Xu XJ. Effect of acute and chronic administration of caffeine on pain-like behaviors in rats with partial sciatic nerve injury. Neuroscience Letters. 402: 164-6. PMID 16644114 DOI: 10.1016/j.neulet.2006.03.065  1
2006 Jonsson M, Dabrowski M, Gurley DA, Larsson O, Johnson EC, Fredholm BB, Eriksson LI. Activation and inhibition of human muscular and neuronal nicotinic acetylcholine receptors by succinylcholine. Anesthesiology. 104: 724-33. PMID 16571968 DOI: 10.1097/00000542-200604000-00017  1
2006 Brown RD, Thorén P, Steege A, Mrowka R, Sällström J, Skøtt O, Fredholm BB, Persson AE. Influence of the adenosine A1 receptor on blood pressure regulation and renin release. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 290: R1324-9. PMID 16357099 DOI: 10.1152/ajpregu.00313.2005  1
2006 Lankford AR, Yang JN, Rose'Meyer R, French BA, Matherne GP, Fredholm BB, Yang Z. Effect of modulating cardiac A1 adenosine receptor expression on protection with ischemic preconditioning. American Journal of Physiology. Heart and Circulatory Physiology. 290: H1469-73. PMID 16299262 DOI: 10.1152/ajpheart.00181.2005  1
2006 Kuzmin A, Johansson B, Gimenez L, Ogren SO, Fredholm BB. Combination of adenosine A1 and A2A receptor blocking agents induces caffeine-like locomotor stimulation in mice. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 16: 129-36. PMID 16054807 DOI: 10.1016/j.euroneuro.2005.07.001  1
2005 NergÃ¥rdh R, Oerther S, Fredholm BB. Differences between A 68930 and SKF 82958 could suggest synergistic roles of D1 and D5 receptors. Pharmacology, Biochemistry, and Behavior. 82: 495-505. PMID 16318870 DOI: 10.1016/j.pbb.2005.09.017  1
2005 Andersson M, Usiello A, Borgkvist A, Pozzi L, Dominguez C, Fienberg AA, Svenningsson P, Fredholm BB, Borrelli E, Greengard P, Fisone G. Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8432-8. PMID 16162925 DOI: 10.1523/JNEUROSCI.1289-05.2005  1
2005 Kim M, Yu ZX, Fredholm BB, Rivkees SA. Susceptibility of the developing brain to acute hypoglycemia involving A1 adenosine receptor activation. American Journal of Physiology. Endocrinology and Metabolism. 289: E562-9. PMID 16150954 DOI: 10.1152/ajpendo.00112.2005  1
2005 Salmi P, Chergui K, Fredholm BB. Adenosine-dopamine interactions revealed in knockout mice. Journal of Molecular Neuroscience : Mn. 26: 239-44. PMID 16012197 DOI: 10.1385/JMN:26:2-3:239  1
2005 Johansson S, Fredholm BB, Hjort C, Morein T, Kull B, Hu PS. Evidence against adenosine analogues being agonists at the growth hormone secretagogue receptor. Biochemical Pharmacology. 70: 598-605. PMID 15979585 DOI: 10.1016/j.bcp.2005.05.023  1
2005 Huang ZL, Qu WM, Eguchi N, Chen JF, Schwarzschild MA, Fredholm BB, Urade Y, Hayaishi O. Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nature Neuroscience. 8: 858-9. PMID 15965471 DOI: 10.1038/nn1491  1
2005 Ammar AA, NergÃ¥rdh R, Fredholm BB, Brodin U, Södersten P. Intake inhibition by NPY and CCK-8: A challenge of the notion of NPY as an "Orexigen". Behavioural Brain Research. 161: 82-7. PMID 15904713 DOI: 10.1016/j.bbr.2005.01.014  1
2005 Giménez-Llort L, Masino SA, Diao L, Fernández-Teruel A, Tobeña A, Halldner L, Fredholm BB. Mice lacking the adenosine A1 receptor have normal spatial learning and plasticity in the CA1 region of the hippocampus, but they habituate more slowly. Synapse (New York, N.Y.). 57: 8-16. PMID 15858837 DOI: 10.1002/syn.20146  1
2005 Fredholm BB, Chen JF, Masino SA, Vaugeois JM. Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs. Annual Review of Pharmacology and Toxicology. 45: 385-412. PMID 15822182 DOI: 10.1146/annurev.pharmtox.45.120403.095731  1
2005 Fredholm BB, Chen JF, Cunha RA, Svenningsson P, Vaugeois JM. Adenosine and brain function. International Review of Neurobiology. 63: 191-270. PMID 15797469 DOI: 10.1016/S0074-7742(05)63007-3  1
2005 Kukley M, Schwan M, Fredholm BB, Dietrich D. The role of extracellular adenosine in regulating mossy fiber synaptic plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2832-7. PMID 15772343 DOI: 10.1523/JNEUROSCI.4260-04.2005  1
2005 Wu WP, Hao JX, Halldner L, Lövdahl C, DeLander GE, Wiesenfeld-Hallin Z, Fredholm BB, Xu XJ. Increased nociceptive response in mice lacking the adenosine A1 receptor. Pain. 113: 395-404. PMID 15661449 DOI: 10.1016/j.pain.2004.11.020  1
2005 Ghanem E, Lövdahl C, Daré E, Ledent C, Fredholm BB, Boeynaems JM, Van Driessche W, Beauwens R. Luminal adenosine stimulates chloride secretion through A1 receptor in mouse jejunum. American Journal of Physiology. Gastrointestinal and Liver Physiology. 288: G972-7. PMID 15637180 DOI: 10.1152/ajpgi.00346.2004  1
2005 Fredholm B, Porreca F. Life Sciences: Editorial Life Sciences. 78: 1. DOI: 10.1016/j.lfs.2005.09.015  1
2004 Schulte G, Sommerschild H, Yang J, Tokuno S, Goiny M, Lövdahl C, Johansson B, Fredholm BB, Valen G. Adenosine A receptors are necessary for protection of the murine heart by remote, delayed adaptation to ischaemia. Acta Physiologica Scandinavica. 182: 133-43. PMID 15450109 DOI: 10.1111/j.1365-201X.2004.01350.x  1
2004 Fredholm BB. [Connection between caffeine, adenosine receptors and dopamine. Coffee reduces the risk of Parkinson disease]. LäKartidningen. 101: 2552-5. PMID 15446691  1
2004 Halldner L, Lopes LV, Daré E, Lindström K, Johansson B, Ledent C, Cunha RA, Fredholm BB. Binding of adenosine receptor ligands to brain of adenosine receptor knock-out mice: evidence that CGS 21680 binds to A1 receptors in hippocampus. Naunyn-Schmiedeberg's Archives of Pharmacology. 370: 270-8. PMID 15378230 DOI: 10.1007/s00210-004-0970-1  1
2004 Olsson T, Cronberg T, Rytter A, Asztély F, Fredholm BB, Smith ML, Wieloch T. Deletion of the adenosine A1 receptor gene does not alter neuronal damage following ischaemia in vivo or in vitro. The European Journal of Neuroscience. 20: 1197-204. PMID 15341591 DOI: 10.1111/j.1460-9568.2004.03564.x  1
2004 Jonsson M, Wyon N, Lindahl SG, Fredholm BB, Eriksson LI. Neuromuscular blocking agents block carotid body neuronal nicotinic acetylcholine receptors. European Journal of Pharmacology. 497: 173-80. PMID 15306202 DOI: 10.1016/j.ejphar.2004.06.052  1
2004 Halldner L, Adén U, Dahlberg V, Johansson B, Ledent C, Fredholm BB. The adenosine A1 receptor contributes to the stimulatory, but not the inhibitory effect of caffeine on locomotion: a study in mice lacking adenosine A1 and/or A2A receptors. Neuropharmacology. 46: 1008-17. PMID 15081797 DOI: 10.1016/j.neuropharm.2004.01.014  1
2004 Fredholm B. Börje Uvnäs and the rise of modern pharmacology Trends in Pharmacological Sciences. 25: 170-171. PMID 15063080 DOI: 10.1016/j.tips.2004.02.003  1
2004 Lopes LV, Halldner L, Rebola N, Johansson B, Ledent C, Chen JF, Fredholm BB, Cunha RA. Binding of the prototypical adenosine A(2A) receptor agonist CGS 21680 to the cerebral cortex of adenosine A(1) and A(2A) receptor knockout mice. British Journal of Pharmacology. 141: 1006-14. PMID 14993095 DOI: 10.1038/sj.bjp.0705692  1
2004 Minelli A, Liguori L, Bellazza I, Mannucci R, Johansson B, Fredholm BB. Involvement of A1 adenosine receptors in the acquisition of fertilizing capacity. Journal of Andrology. 25: 286-92. PMID 14760015  1
2004 Hammarberg C, Fredholm BB, Schulte G. Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3'-kinase. Biochemical Pharmacology. 67: 129-34. PMID 14667935  1
2004 Hammarberg C, Fredholm BB, Schulte G. Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3′-kinase Biochemical Pharmacology. 67: 129-134. DOI: 10.1016/j.bcp.2003.08.031  1
2003 Svenningsson P, Fredholm BB. Exciting news about A2A receptors. Neurology. 61: S10-1. PMID 14663002  1
2003 Fredholm BB, Svenningsson P. Adenosine-dopamine interactions: development of a concept and some comments on therapeutic possibilities. Neurology. 61: S5-9. PMID 14663001  1
2003 Stenberg D, Litonius E, Halldner L, Johansson B, Fredholm BB, Porkka-Heiskanen T. Sleep and its homeostatic regulation in mice lacking the adenosine A1 receptor. Journal of Sleep Research. 12: 283-90. PMID 14633239  1
2003 Schulte G, Robertson B, Fredholm BB, DeLander GE, Shortland P, Molander C. Distribution of antinociceptive adenosine A1 receptors in the spinal cord dorsal horn, and relationship to primary afferents and neuronal subpopulations. Neuroscience. 121: 907-16. PMID 14580941 DOI: 10.1016/S0306-4522(03)00480-9  1
2003 Schulte G, Fredholm BB. The G(s)-coupled adenosine A(2B) receptor recruits divergent pathways to regulate ERK1/2 and p38. Experimental Cell Research. 290: 168-76. PMID 14516797 DOI: 10.1016/S0014-4827(03)00324-0  1
2003 Turner CP, Seli M, Ment L, Stewart W, Yan H, Johansson B, Fredholm BB, Blackburn M, Rivkees SA. A1 adenosine receptors mediate hypoxia-induced ventriculomegaly. Proceedings of the National Academy of Sciences of the United States of America. 100: 11718-22. PMID 12975523 DOI: 10.1073/pnas.1931975100  1
2003 Fredholm BB. Adenosine receptors as targets for drug development. Drug News & Perspectives. 16: 283-9. PMID 12942159 DOI: 10.1358/dnp.2003.16.5.829316  1
2003 Hammarberg C, Schulte G, Fredholm BB. Evidence for functional adenosine A3 receptors in microglia cells. Journal of Neurochemistry. 86: 1051-4. PMID 12887702 DOI: 10.1046/j.1471-4159.2003.01919.x  1
2003 Lynge J, Schulte G, Nordsborg N, Fredholm BB, Hellsten Y. Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells. Biochemical and Biophysical Research Communications. 307: 180-7. PMID 12849998 DOI: 10.1016/S0006-291X(03)01125-2  1
2003 Schulte G, Fredholm BB. Signalling from adenosine receptors to mitogen-activated protein kinases. Cellular Signalling. 15: 813-27. PMID 12834807 DOI: 10.1016/S0898-6568(03)00058-5  1
2003 Fredholm BB, Assender JW, Irenius E, Kodama N, Saito N. Synergistic effects of adenosine A1 and P2Y receptor stimulation on calcium mobilization and PKC translocation in DDT1 MF-2 cells. Cellular and Molecular Neurobiology. 23: 379-400. PMID 12825834 DOI: 10.1023/A:1023644822539  1
2003 Adén U, Halldner L, Lagercrantz H, Dalmau I, Ledent C, Fredholm BB. Aggravated brain damage after hypoxic ischemia in immature adenosine A2A knockout mice. Stroke; a Journal of Cerebral Circulation. 34: 739-44. PMID 12624301 DOI: 10.1161/01.STR.0000060204.67672.8B  1
2003 Fredholm BB, Cunha RA, Svenningsson P. Pharmacology of adenosine A2A receptors and therapeutic applications. Current Topics in Medicinal Chemistry. 3: 413-26. PMID 12570759  1
2003 Lopes LV, Rebola N, Costenla AR, Halldner L, Jacobson MA, Oliveira CR, Richardson PJ, Fredholm BB, Ribeiro JA, Cunha RA. Adenosine A3 receptors in the rat hippocampus: Lack of interaction with A1 receptors Drug Development Research. 58: 428-438. DOI: 10.1002/ddr.10188  1
2003 Fredholm BB, Halldner L, Johansson C, Schulte G, Lövdahl C, Thorén P, Dunwiddie TV, Masino SA, Poelchen W, Diao L, Illes P, Zahniser NR, Valen G, Tokuno S, Sommerschild H, et al. Consequences of eliminating adenosine A1 receptors in mice Drug Development Research. 58: 350-353. DOI: 10.1002/ddr.10170  1
2003 Fredholm BB. Caffeine and the biological role of adenosine receptors | Cafeína y función biológica de los receptores de adenosina Anales De La Real Academia Nacional De Farmacia. 69: 685-717.  1
2002 Schulte G, Fredholm BB. Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2. Molecular Pharmacology. 62: 1137-46. PMID 12391277 DOI: 10.1124/mol.62.5.1137  1
2002 Masino SA, Diao L, Illes P, Zahniser NR, Larson GA, Johansson B, Fredholm BB, Dunwiddie TV. Modulation of hippocampal glutamatergic transmission by ATP is dependent on adenosine a(1) receptors. The Journal of Pharmacology and Experimental Therapeutics. 303: 356-63. PMID 12235271 DOI: 10.1124/jpet.102.036731  1
2002 Wu WP, Hao JX, Halldner-Henriksson L, Xu XJ, Jacobson MA, Wiesenfeld-Hallin Z, Fredholm BB. Decreased inflammatory pain due to reduced carrageenan-induced inflammation in mice lacking adenosine A3 receptors. Neuroscience. 114: 523-7. PMID 12220556 DOI: 10.1016/S0306-4522(02)00273-7  1
2002 Giménez-Llort L, Fernández-Teruel A, Escorihuela RM, Fredholm BB, Tobeña A, Pekny M, Johansson B. Mice lacking the adenosine A1 receptor are anxious and aggressive, but are normal learners with reduced muscle strength and survival rate. The European Journal of Neuroscience. 16: 547-50. PMID 12193199 DOI: 10.1046/j.1460-9568.2002.02122.x  1
2002 Lindskog M, Svenningsson P, Pozzi L, Kim Y, Fienberg AA, Bibb JA, Fredholm BB, Nairn AC, Greengard P, Fisone G. Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Nature. 418: 774-8. PMID 12181566 DOI: 10.1038/nature00817  1
2002 Fredholm BB, Fleming WW, Vanhoutte PM, Godfraind T. The role of pharmacology in drug discovery. Nature Reviews. Drug Discovery. 1: 237-8. PMID 12120508 DOI: 10.1038/nrd749  1
2002 Lopes LV, Cunha RA, Kull B, Fredholm BB, Ribeiro JA. Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition. Neuroscience. 112: 319-29. PMID 12044450 DOI: 10.1016/S0306-4522(02)00080-5  1
2002 Fredholm BB. [The passion concerning behavior of human beings. The intensive sociology debate and some lessons learned from it]. LäKartidningen. 99: 1604-8. PMID 12025216  0.4
2002 Adén U, Dahlberg V, Fredholm BB, Lai LJ, Chen Z, Bjelke B. MRI evaluation and functional assessment of brain injury after hypoxic ischemia in neonatal mice. Stroke; a Journal of Cerebral Circulation. 33: 1405-10. PMID 11988622 DOI: 10.1161/01.STR.0000014608.78503.DB  1
2002 Arslan G, Kull B, Fredholm BB. Anoxia redistributes adenosine A(2A) receptors in PC12 cells and increases receptor-mediated formation of cAMP. Naunyn-Schmiedeberg's Archives of Pharmacology. 365: 150-7. PMID 11819033 DOI: 10.1007/s002100100456  1
2002 Schulte G, Fredholm BB. Diverse inhibitors of intracellular signalling act as adenosine receptor antagonists. Cellular Signalling. 14: 109-13. PMID 11781134 DOI: 10.1016/S0898-6568(01)00228-5  1
2001 Fredholm BB, IJzerman AP, Jacobson KA, Klotz KN, Linden J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacological Reviews. 53: 527-52. PMID 11734617  1
2001 Brown R, Ollerstam A, Johansson B, Skøtt O, Gebre-Medhin S, Fredholm B, Persson AEG. Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor-deficient mice American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 281: R1362-R1367. PMID 11641103  1
2001 Adén U, Leverin AL, Hagberg H, Fredholm BB. Adenosine A(1) receptor agonism in the immature rat brain and heart. European Journal of Pharmacology. 426: 185-92. PMID 11527543 DOI: 10.1016/S0014-2999(01)01220-1  1
2001 Fredholm BB, Sjöqvist F. [Pharmacology at the start of a new millennium. Larger assortment and individual drug dosing are coming]. LäKartidningen. 98: 534-9. PMID 11475239  1
2001 Johansson B, Halldner L, Dunwiddie TV, Masino SA, Poelchen W, Giménez-Llort L, Escorihuela RM, Fernández-Teruel A, Wiesenfeld-Hallin Z, Xu XJ, HÃ¥rdemark A, Betsholtz C, Herlenius E, Fredholm BB. Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proceedings of the National Academy of Sciences of the United States of America. 98: 9407-12. PMID 11470917 DOI: 10.1073/pnas.161292398  1
2001 Basheer R, Halldner L, Alanko L, McCarley RW, Fredholm BB, Porkka-Heiskanen T. Opposite changes in adenosine A1 and A2A receptor mRNA in the rat following sleep deprivation. Neuroreport. 12: 1577-80. PMID 11409719  1
2001 Fredholm BB, Irenius E, Kull B, Schulte G. Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells. Biochemical Pharmacology. 61: 443-8. PMID 11226378 DOI: 10.1016/S0006-2952(00)00570-0  1
2001 Fredholm BB, Arslan G, Halldner L, Kull B, Schulte G, Ådén U, Svenningsson P. Adenosine receptor signaling in vitro and in vivo Drug Development Research. 52: 274-282. DOI: 10.1002/ddr.1124  1
2000 Pintor J, Miras-Portugal T, Fredholm BB. Research on purines and their receptors comes of age. Trends in Pharmacological Sciences. 21: 453-6. PMID 11229416 DOI: 10.1016/S0165-6147(00)01566-2  1
2000 Fredholm BB, Arslan G, Halldner L, Kull B, Schulte G, Wasserman W. Structure and function of adenosine receptors and their genes. Naunyn-Schmiedeberg's Archives of Pharmacology. 362: 364-74. PMID 11111830 DOI: 10.1007/s002100000313  1
2000 Halldner L, Lozza G, Lindström K, Fredholm BB. Lack of tolerance to motor stimulant effects of a selective adenosine A(2A) receptor antagonist. European Journal of Pharmacology. 406: 345-54. PMID 11040341 DOI: 10.1016/S0014-2999(00)00682-8  1
2000 Arslan G, Fredholm BB. Stimulatory and inhibitory effects of adenosine A(2A) receptors on nerve growth factor-induced phosphorylation of extracellular regulated kinases 1/2 in PC12 cells. Neuroscience Letters. 292: 183-6. PMID 11018307 DOI: 10.1016/S0304-3940(00)01461-0  1
2000 Kull B, Svenningsson P, Fredholm BB. Adenosine A(2A) receptors are colocalized with and activate g(olf) in rat striatum. Molecular Pharmacology. 58: 771-7. PMID 10999947  1
2000 Kull B, Svenningsson P, Hall H, Fredholm BB. GTP differentially affects antagonist radioligand binding to adenosine A(1) and A(2A) receptors in human brain. Neuropharmacology. 39: 2374-80. PMID 10974321 DOI: 10.1016/S0028-3908(00)00081-2  1
2000 Kuzmin A, Johansson B, Semenova S, Fredholm BB. Differences in the effect of chronic and acute caffeine on self-administration of cocaine in mice. The European Journal of Neuroscience. 12: 3026-32. PMID 10971643 DOI: 10.1046/j.1460-9568.2000.00179.x  1
2000 Schulte G, Fredholm BB. Human adenosine A(1), A(2A), A(2B), and A(3) receptors expressed in Chinese hamster ovary cells all mediate the phosphorylation of extracellular-regulated kinase 1/2. Molecular Pharmacology. 58: 477-82. PMID 10953039  1
2000 Zahniser NR, Simosky JK, Mayfield RD, Negri CA, Hanania T, Larson GA, Kelly MA, Grandy DK, Rubinstein M, Low MJ, Fredholm BB. Functional uncoupling of adenosine A(2A) receptors and reduced responseto caffeine in mice lacking dopamine D2 receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 5949-57. PMID 10934242  1
2000 Adén U, Herlenius E, Tang LQ, Fredholm BB. Maternal caffeine intake has minor effects on adenosine receptor ontogeny in the rat brain. Pediatric Research. 48: 177-83. PMID 10926292 DOI: 10.1203/00006450-200008000-00010  1
2000 Berman RF, Fredholm BB, Aden U, O'Connor WT. Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats. Brain Research. 872: 44-53. PMID 10924674 DOI: 10.1016/S0006-8993(00)02441-0  1
2000 Svenningsson P, Fredholm BB, Bloch B, Le Moine C. Co-stimulation of D(1)/D(5) and D(2) dopamine receptors leads to an increase in c-fos messenger RNA in cholinergic interneurons and a redistribution of c-fos messenger RNA in striatal projection neurons. Neuroscience. 98: 749-57. PMID 10891618 DOI: 10.1016/S0306-4522(00)00155-X  1
2000 Broad RM, Fallahi N, Fredholm BB. Nitric oxide interacts with oxygen free radicals to evoke the release of adenosine and adenine nucleotides from rat hippocampal slices. Journal of the Autonomic Nervous System. 81: 82-6. PMID 10869705 DOI: 10.1016/S0165-1838(00)00124-7  1
2000 Svenningsson P, Fienberg AA, Allen PB, Moine CL, Lindskog M, Fisone G, Greengard P, Fredholm BB. Dopamine D(1) receptor-induced gene transcription is modulated by DARPP-32. Journal of Neurochemistry. 75: 248-57. PMID 10854268 DOI: 10.1046/j.1471-4159.2000.0750248.x  1
2000 Fredholm BB. [The journey from genome structure to cure of diseases is long and winding. Research specialists in molecular biology and physiology should cooperate]. LäKartidningen. 97: 2046-8. PMID 10850032  1
2000 Vainio M, Fredholm BB, Törnquist K. Thyrotropin regulates adenosine A(1) receptor expression in rat thyroid FRTL-5 cells. British Journal of Pharmacology. 130: 471-7. PMID 10807688 DOI: 10.1038/sj.bjp.0703325  1
2000 Arslan G, Filipeanu CM, Irenius E, Kull B, Clementi E, Allgaier C, Erlinge D, Fredholm BB. P2Y receptors contribute to ATP-induced increases in intracellular calcium in differentiated but not undifferentiated PC12 cells. Neuropharmacology. 39: 482-96. PMID 10698014 DOI: 10.1016/S0028-3908(99)00141-0  1
2000 Kuzmin A, Johansson B, Fredholm BB, Ogren SO. Genetic evidence that cocaine and caffeine stimulate locomotion in mice via different mechanisms. Life Sciences. 66: PL113-8. PMID 10680584 DOI: 10.1016/S0024-3205(99)00647-5  1
2000 Svenningsson P, Lindskog M, Ledent C, Parmentier M, Greengard P, Fredholm BB, Fisone G. Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D1, dopamine D2, and adenosine A2A receptors. Proceedings of the National Academy of Sciences of the United States of America. 97: 1856-60. PMID 10677546 DOI: 10.1073/pnas.97.4.1856  1
1999 Fredholm BB. [Vademecum of a biomedical researcher: from the foundation of science to the threat from post-modern "nonsense"]. LäKartidningen. 96: 5639-44. PMID 10643231  1
1999 Arslan G, Fredholm BB. Adenosine and P2 receptors in PC12 cells. Genotypic, phenotypic and individual differences. Progress in Brain Research. 120: 301-10. PMID 10551006  1
1999 Fredholm BB, Lindström K. Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A1 and A(2A) receptors. European Journal of Pharmacology. 380: 197-202. PMID 10513579 DOI: 10.1016/S0014-2999(99)00533-6  1
1999 Kull B, Ferré S, Arslan G, Svenningsson P, Fuxe K, Owman C, Fredholm BB. Reciprocal interactions between adenosine A2A and dopamine D2 receptors in Chinese hamster ovary cells co-transfected with the two receptors. Biochemical Pharmacology. 58: 1035-45. PMID 10509756 DOI: 10.1016/S0006-2952(99)00184-7  1
1999 Svenningsson P, Le Moine C, Fisone G, Fredholm BB. Distribution, biochemistry and function of striatal adenosine A2A receptors. Progress in Neurobiology. 59: 355-96. PMID 10501634 DOI: 10.1016/S0301-0082(99)00011-8  1
1999 Kuzmin A, Johansson B, Zvartau EE, Fredholm BB. Caffeine, acting on adenosine A(1) receptors, prevents the extinction of cocaine-seeking behavior in mice. The Journal of Pharmacology and Experimental Therapeutics. 290: 535-42. PMID 10411560  1
1999 Lillrank SM, Lipska BK, Weinberger DR, Fredholm BB, Fuxe K, Ferré S. Adenosine and dopamine receptor antagonist binding in the rat ventral and dorsal striatum: lack of changes after a neonatal bilateral lesion of the ventral hippocampus. Neurochemistry International. 34: 235-44. PMID 10355490 DOI: 10.1016/S0197-0186(99)00008-X  1
1999 Lindskog M, Svenningsson P, Fredholm B, Greengard P, Fisone G. Mu- and delta-opioid receptor agonists inhibit DARPP-32 phosphorylation in distinct populations of striatal projection neurons. The European Journal of Neuroscience. 11: 2182-6. PMID 10336688 DOI: 10.1046/j.1460-9568.1999.00597.x  1
1999 Lindskog M, Svenningsson P, Fredholm BB, Greengard P, Fisone G. Activation of dopamine D2 receptors decreases DARPP-32 phosphorylation in striatonigral and striatopallidal projection neurons via different mechanisms. Neuroscience. 88: 1005-8. PMID 10336115 DOI: 10.1016/S0306-4522(98)00411-4  1
1999 Svenningsson P, Nomikos GG, Fredholm BB. The stimulatory action and the development of tolerance to caffeine is associated with alterations in gene expression in specific brain regions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 4011-22. PMID 10234030  1
1999 Svenningsson P, Fourreau L, Bloch B, Fredholm BB, Gonon F, Le Moine C. Opposite tonic modulation of dopamine and adenosine on c-fos gene expression in striatopallidal neurons. Neuroscience. 89: 827-37. PMID 10199616 DOI: 10.1016/S0306-4522(98)00403-5  1
1999 Fredholm BB, Bättig K, Holmén J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacological Reviews. 51: 83-133. PMID 10049999  1
1999 Arslan G, Kull B, Fredholm BB. Signaling via A2A adenosine receptor in four PC12 cell clones. Naunyn-Schmiedeberg's Archives of Pharmacology. 359: 28-32. PMID 9933147  1
1999 Ongini E, Dionisotti S, Gessi S, Irenius E, Fredholm BB. Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. 359: 7-10. PMID 9933143  0.4
1999 Kull B, Arslan G, Nilsson C, Owman C, Lorenzen A, Schwabe U, Fredholm BB. Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors. Biochemical Pharmacology. 57: 65-75. PMID 9920286 DOI: 10.1016/S0006-2952(98)00298-6  1
1998 Daly JW, Holmén J, Fredholm BB. [Is caffeine addictive? The most widely used psychoactive substance in the world affects same parts of the brain as cocaine]. LäKartidningen. 95: 5878-83. PMID 9889511  1
1998 Köhler M, Norgren S, Berggren PO, Fredholm BB, Larsson O, Rhodes CJ, Herbert TP, Luthman H. Changes in cytoplasmic ATP concentration parallels changes in ATP-regulated K+-channel activity in insulin-secreting cells. Febs Letters. 441: 97-102. PMID 9877173 DOI: 10.1016/S0014-5793(98)01539-7  1
1998 Svenningsson P, Le Moine C, Aubert I, Burbaud P, Fredholm BB, Bloch B. Cellular distribution of adenosine A2A receptor mRNA in the primate striatum. The Journal of Comparative Neurology. 399: 229-40. PMID 9721905 DOI: 10.1002/(SICI)1096-9861(19980921)399:2<229::AID-CNE6>3.0.CO;2-2  1
1998 Daly JW, Fredholm BB. Caffeine--an atypical drug of dependence. Drug and Alcohol Dependence. 51: 199-206. PMID 9716941 DOI: 10.1016/S0376-8716(98)00077-5  1
1998 Svenningsson P, NergÃ¥rdh R, Fredholm BB. Regional differences in the ability of caffeine to affect haloperidol-induced striatal c-fos mRNA expression in the rat. Neuropharmacology. 37: 331-7. PMID 9681931 DOI: 10.1016/S0028-3908(98)00045-8  1
1998 Fredholm BB, Johansson B, Lindström K, Wahlström G. Age-dependent changes in adenosine receptors are not modified by life-long intermittent alcohol administration. Brain Research. 791: 177-85. PMID 9593882 DOI: 10.1016/S0006-8993(98)00090-0  1
1998 Fredholm BB, Svenningsson P. Striatal adenosine A2A receptors--where are they? What do they do? Trends in Pharmacological Sciences. 19: 46-8. PMID 9550940 DOI: 10.1016/S0165-6147(97)01160-7  1
1998 Svenningsson P, Lindskog M, Rognoni F, Fredholm BB, Greengard P, Fisone G. Activation of adenosine A2A and dopamine D1 receptors stimulates cyclic AMP-dependent phosphorylation of DARPP-32 in distinct populations of striatal projection neurons. Neuroscience. 84: 223-8. PMID 9522376 DOI: 10.1016/S0306-4522(97)00510-1  1
1998 Fredholm BB. [Thoughts at the start of a new year. What happens to time?]. LäKartidningen. 95: 534-5. PMID 9494359  1
1998 Fredholm BB, Lindström K, Dionisotti S, Ongini E. [3H]SCH 58261, a selective adenosine A2A receptor antagonist, is a useful ligand in autoradiographic studies. Journal of Neurochemistry. 70: 1210-6. PMID 9489743  1
1998 Ferré S, Torvinen M, Antoniou K, Irenius E, Civelli O, Arenas E, Fredholm BB, Fuxe K. Adenosine A1 receptor-mediated modulation of dopamine D1 receptors in stably cotransfected fibroblast cells. The Journal of Biological Chemistry. 273: 4718-24. PMID 9468534 DOI: 10.1074/jbc.273.8.4718  1
1998 Klotz KN, Hessling J, Hegler J, Owman C, Kull B, Fredholm BB, Lohse MJ. Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's Archives of Pharmacology. 357: 1-9. PMID 9459566 DOI: 10.1007/PL00005131  1
1998 Fredholm BB, Arslan G, Kuli B, Svenningsson P. Locating the neuronal targets for caffeine Drug Development Research. 45: 324-328.  1
1997 Jin S, Fredholm BB. Glucose deprivation increases basal and electrically evoked transmitter release from rat striatal slices. Role of NMDA and adenosine A1 receptors. European Journal of Pharmacology. 340: 169-75. PMID 9537811 DOI: 10.1016/S0014-2999(97)01437-4  1
1997 Chergui K, Svenningsson P, Nomikos GG, Gonon F, Fredholm BB, Svennson TH. Increased expression of NGFI-A mRNA in the rat striatum following burst stimulation of the medial forebrain bundle. The European Journal of Neuroscience. 9: 2370-82. PMID 9464931  1
1997 Fredholm B. Our genetic differences confirm the idea on equal value of all human beings | Våra genetiska olikheter befäster idén om allas lika värde LäKartidningen. 94: 4650-4651. PMID 9445940  1
1997 Delander GE, Schött E, Brodin E, Fredholm BB. Spinal expression of mRNA for immediate early genes in a model of chronic pain. Acta Physiologica Scandinavica. 161: 517-25. PMID 9429660 DOI: 10.1046/j.1365-201X.1997.00260.x  1
1997 Delander GE, Schött E, Brodin E, Fredholm BB. Temporal changes in spinal cord expression of mRNA for substance P, dynorphin and enkephalin in a model of chronic pain. Acta Physiologica Scandinavica. 161: 509-16. PMID 9429659 DOI: 10.1046/j.1365-201X.1997.00259.x  1
1997 Svenningsson P, Georgieva J, Kontny E, Heilig M, Fredholm BB. Involvement of a c-fos-dependent mechanism in caffeine-induced expression of the preprotachykinin A and neurotensin/neuromedin N genes in rat striatum. The European Journal of Neuroscience. 9: 2135-41. PMID 9421173 DOI: 10.1111/j.1460-9568.1997.tb01380.x  1
1997 Svenningsson P, Hall H, Sedvall G, Fredholm BB. Distribution of adenosine receptors in the postmortem human brain: an extended autoradiographic study. Synapse (New York, N.Y.). 27: 322-35. PMID 9372555 DOI: 10.1002/(SICI)1098-2396(199712)27:4<322::AID-SYN6>3.0.CO;2-E  1
1997 Kvanta A, Seregard S, Sejersen S, Kull B, Fredholm BB. Localization of adenosine receptor messenger RNAs in the rat eye. Experimental Eye Research. 65: 595-602. PMID 9367639 DOI: 10.1006/exer.1996.0352  1
1997 Bona E, Adén U, Gilland E, Fredholm BB, Hagberg H. Neonatal cerebral hypoxia-ischemia: the effect of adenosine receptor antagonists. Neuropharmacology. 36: 1327-38. PMID 9364488 DOI: 10.1016/S0028-3908(97)00139-1  1
1997 Arslan G, Kontny E, Fredholm BB. Down-regulation of adenosine A2A receptors upon NGF-induced differentiation of PC12 cells. Neuropharmacology. 36: 1319-26. PMID 9364487 DOI: 10.1016/S0028-3908(97)00090-7  1
1997 Svenningsson P, Fredholm BB. Caffeine mimics the effect of a dopamine D2/3 receptor agonist on the expression of immediate early genes in globus pallidus. Neuropharmacology. 36: 1309-17. PMID 9364486 DOI: 10.1016/S0028-3908(97)00091-9  1
1997 Ferré S, Fredholm BB, Morelli M, Popoli P, Fuxe K. Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Trends in Neurosciences. 20: 482-7. PMID 9347617  0.96
1997 Le Moine C, Svenningsson P, Fredholm BB, Bloch B. Dopamine-adenosine interactions in the striatum and the globus pallidus: inhibition of striatopallidal neurons through either D2 or A2A receptors enhances D1 receptor-mediated effects on c-fos expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 8038-48. PMID 9315922  1
1997 Johansson B, Georgiev V, Fredholm BB. Distribution and postnatal ontogeny of adenosine A2A receptors in rat brain: comparison with dopamine receptors. Neuroscience. 80: 1187-207. PMID 9284070  0.8
1997 Svenningsson P, Le Moine C, Kull B, Sunahara R, Bloch B, Fredholm BB. Cellular expression of adenosine A2A receptor messenger RNA in the rat central nervous system with special reference to dopamine innervated areas. Neuroscience. 80: 1171-85. PMID 9284069 DOI: 10.1016/S0306-4522(97)00180-2  1
1997 Johansson B, Georgiev V, Lindström K, Fredholm BB. A1 and A2A adenosine receptors and A1 mRNA in mouse brain: effect of long-term caffeine treatment. Brain Research. 762: 153-64. PMID 9262169  0.8
1997 Assender JW, Irenius E, Fredholm BB. 5-Hydroxytryptamine, angiotensin and bradykinin transiently increase intracellular calcium concentrations and PKC-alpha activity, but do not induce mitogenesis in human vascular smooth muscle cells. Acta Physiologica Scandinavica. 160: 207-17. PMID 9246383 DOI: 10.1046/j.1365-201X.1997.00157.x  0.52
1997 Svenningsson P, Nomikos GG, Ongini E, Fredholm BB. Antagonism of adenosine A2A receptors underlies the behavioural activating effect of caffeine and is associated with reduced expression of messenger RNA for NGFI-A and NGFI-B in caudate-putamen and nucleus accumbens. Neuroscience. 79: 753-64. PMID 9219939 DOI: 10.1016/S0306-4522(97)00046-8  1
1997 Dionisotti S, Ongini E, Zocchi C, Kull B, Arslan G, Fredholm BB. Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261. British Journal of Pharmacology. 121: 353-60. PMID 9179373 DOI: 10.1038/sj.bjp.0701119  0.84
1997 Fredholm BB, Abbracchio MP, Burnstock G, Dubyak GR, Harden TK, Jacobson KA, Schwabe U, Williams M. Towards a revised nomenclature for P1 and P2 receptors. Trends in Pharmacological Sciences. 18: 79-82. PMID 9133776 DOI: 10.1016/S0165-6147(96)01038-3  1
1997 Stone-Elander S, Thorell JO, Eriksson L, Fredholm BB, Ingvar M. In vivo biodistribution of [N-11C-methyl]KF 17837 using 3-D-PET: evaluation as a ligand for the study of adenosine A2A receptors. Nuclear Medicine and Biology. 24: 187-91. PMID 9089711 DOI: 10.1016/S0969-8051(96)00216-8  1
1997 Kontny E, Ciruela F, Svenningsson P, Ibáñez CF, Fredholm BB. On the role of the low-affinity neurotrophin receptor p75LNTR in nerve growth factor induction of differentiation and AP 1 binding activity in PC12 cells. Journal of Molecular Neuroscience : Mn. 8: 29-44. PMID 9061613 DOI: 10.1007/BF02736861  1
1997 Svenningsson P, Fredholm BB. Glucocorticoids regulate the expression of adenosine A1 but not A(2A) receptors in rat brain. The Journal of Pharmacology and Experimental Therapeutics. 280: 1094-101. PMID 9023328  1
1996 Johansson B, Georgiev V, Kuosmanen T, Fredholm BB. Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding. The European Journal of Neuroscience. 8: 2447-58. PMID 8996794  0.8
1996 Dasgupta S, Ferré S, Kull B, Hedlund PB, Finnman UB, Ahlberg S, Arenas E, Fredholm BB, Fuxe K. Adenosine A2A receptors modulate the binding characteristics of dopamine D2 receptors in stably cotransfected fibroblast cells. European Journal of Pharmacology. 316: 325-31. PMID 8982704  0.96
1996 Jacobson KA, von Lubitz DK, Daly JW, Fredholm BB. Adenosine receptor ligands: differences with acute versus chronic treatment. Trends in Pharmacological Sciences. 17: 108-13. PMID 8936347 DOI: 10.1016/0165-6147(96)10002-X  1
1996 Lindström K, Ongini E, Fredholm BB. The selective adenosine A2A receptor antagonist SCH 58261 discriminates between two different binding sites for [3H]-CGS 21680 in the rat brain. Naunyn-Schmiedeberg's Archives of Pharmacology. 354: 539-41. PMID 8897460  0.36
1996 Fredholm BB, Zhang Y, van der Ploeg I. Adenosine A2A receptors mediate the inhibitory effect of adenosine on formyl-Met-Leu-Phe-stimulated respiratory burst in neutrophil leucocytes. Naunyn-Schmiedeberg's Archives of Pharmacology. 354: 262-7. PMID 8878055  0.64
1996 Assender JW, Irenius E, Fredholm BB. Endothelin-1 causes a prolonged protein kinase C activation and acts as a co-mitogen in vascular smooth muscle cells. Acta Physiologica Scandinavica. 157: 451-60. PMID 8869728 DOI: 10.1046/j.1365-201X.1996.511285000.x  0.52
1996 Fredholm BB, Adén U, Lindström K, Bona E, Hagberg H. Caffeine and ischemia--effects on immediate early genes and adenosine receptors. Advances in Neurology. 71: 469-74. PMID 8790821  0.36
1996 Ferre S, O'Connor WT, Svenningsson P, Bjorklund L, Lindberg J, Tinner B, Stromberg I, Goldstein M, Ogren SO, Ungerstedt U, Fredholm BB, Fuxe K. Dopamine D1 receptor-mediated facilitation of GABAergic neurotransmission in the rat strioentopenduncular pathway and its modulation by adenosine A1 receptor-mediated mechanisms. The European Journal of Neuroscience. 8: 1545-53. PMID 8758962  1
1996 Jiang S, Kull B, Fredholm BB, Orrenius S. P2x purinoceptor is not important in thymocyte apoptosis. Immunology Letters. 49: 197-201. PMID 8739317 DOI: 10.1016/0165-2478(96)02507-2  0.84
1996 Svenningsson P, Johansson B, Fredholm BB. Caffeine-induced expression of c-fos mRNA and NGFI-A mRNA in caudate putamen and in nucleus accumbens are differentially affected by the N-methyl-D-aspartate receptor antagonist MK-801. Brain Research. Molecular Brain Research. 35: 183-9. PMID 8717354  1
1996 Cunha RA, Johansson B, Constantino MD, Sebastião AM, Fredholm BB. Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. 353: 261-71. PMID 8692280  0.88
1996 van der Ploeg I, Ahlberg S, Parkinson FE, Olsson RA, Fredholm BB. Functional characterization of adenosine A2 receptors in Jurkat cells and PC12 cells using adenosine receptor agonists. Naunyn-Schmiedeberg's Archives of Pharmacology. 353: 250-60. PMID 8692279 DOI: 10.1007/BF00168626  1
1996 Parkinson FE, Johansson B, Lindström K, Fredholm BB. Adenosine A1 and A2A receptors and nitrobenzylthioinosine-sensitive transporters in gerbil brain: no changes following long-term treatment with the adenosine transport inhibitor propentofylline. Neuropharmacology. 35: 79-89. PMID 8684600 DOI: 10.1016/0028-3908(95)00155-7  1
1996 Fernandez M, Svenningsson P, Fredholm BB. Adaptive changes in adenosine receptors following long-term treatment with the adenosine receptor agonist R-phenylisopropyl adenosine. Life Sciences. 58: 769-76. PMID 8632724 DOI: 10.1016/0024-3205(95)02355-0  1
1995 Assender JW, Irenius E, Fredholm BB. Protein kinase C isoform expression and ATP response change with smooth muscle cell differentiation. Biochemical Society Transactions. 23: 453S. PMID 8566344  0.52
1995 Gerwins P, Fredholm BB. Activation of phospholipase C and phospholipase D by stimulation of adenosine A1, bradykinin or P2U receptors does not correlate well with protein kinase C activation. Naunyn-Schmiedeberg's Archives of Pharmacology. 351: 194-201. PMID 7770101  0.44
1995 Gerwins P, Fredholm BB. Activation of adenosine A1 and bradykinin receptors increases protein kinase C and phospholipase D activity in smooth muscle cells. Naunyn-Schmiedeberg's Archives of Pharmacology. 351: 186-93. PMID 7770100  0.44
1995 Svenningsson P, Ström A, Johansson B, Fredholm BB. Increased expression of c-jun, junB, AP-1, and preproenkephalin mRNA in rat striatum following a single injection of caffeine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 3583-93. PMID 7751931  1
1995 Svenningsson P, Johansson B, Fredholm BB. Effect of different xanthines and phosphodiesterase inhibitors on c-fos expression in rat striatum. Acta Physiologica Scandinavica. 154: 17-24. PMID 7572198 DOI: 10.1111/j.1748-1716.1995.tb09881.x  1
1995 Johansson B, Fredholm BB. Further characterization of the binding of the adenosine receptor agonist [3H]CGS 21680 to rat brain using autoradiography. Neuropharmacology. 34: 393-403. PMID 7566470  0.8
1995 Cunha RA, Johansson B, Fredholm BB, Ribeiro JA, Sebastião AM. Adenosine A2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus. Neuroscience Letters. 196: 41-4. PMID 7501252  0.88
1995 Bona E, Adén U, Fredholm BB, Hagberg H. The effect of long term caffeine treatment on hypoxic-ischemic brain damage in the neonate. Pediatric Research. 38: 312-8. PMID 7494652 DOI: 10.1203/00006450-199509000-00007  0.36
1995 Svenningsson P, Nomikos GG, Fredholm BB. Biphasic changes in locomotor behavior and in expression of mRNA for NGFI-A and NGFI-B in rat striatum following acute caffeine administration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 7612-24. PMID 7472512  1
1994 Fredholm BB, Lindström K, Wallman-Johansson A. Propentofylline and other adenosine transport inhibitors increase the efflux of adenosine following electrical or metabolic stimulation of rat hippocampal slices. Journal of Neurochemistry. 62: 563-73. PMID 8294919  0.36
1994 Assender JW, Kontny E, Fredholm BB. Expression of protein kinase C isoforms in smooth muscle cells in various states of differentiation. Febs Letters. 342: 76-80. PMID 8143854  0.32
1994 Adén U, Lindström K, Bona E, Hagberg H, Fredholm BB. Changes in adenosine receptors in the neonatal rat brain following hypoxic ischemia. Brain Research. Molecular Brain Research. 23: 354-8. PMID 8090076  0.36
1994 Dunér-Engström M, Fredholm BB. Carbachol-induced phosphatidylcholine hydrolysis and choline efflux in rat submandibular gland involves phospholipase D activation and is modulated by protein kinase C and calcium. Acta Physiologica Scandinavica. 151: 515-25. PMID 7976425 DOI: 10.1111/j.1748-1716.1994.tb09774.x  0.56
1994 Cunha RA, Johansson B, van der Ploeg I, Sebastião AM, Ribeiro JA, Fredholm BB. Evidence for functionally important adenosine A2a receptors in the rat hippocampus. Brain Research. 649: 208-16. PMID 7953635  0.88
1994 Fredholm BB, Altiok N. Adenosine A2B receptor signalling is altered by stimulation of bradykinin or interleukin receptors in astroglioma cells. Neurochemistry International. 25: 99-102. PMID 7950978  0.6
1994 Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M. Nomenclature and classification of purinoceptors. Pharmacological Reviews. 46: 143-56. PMID 7938164  1
1994 Parkinson FE, Rudolphi KA, Fredholm BB. Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia. General Pharmacology. 25: 1053-8. PMID 7875526 DOI: 10.1016/0306-3623(94)90119-8  1
1994 Snaprud P, Gerwins P, Caron MG, Libert F, Persson H, Fredholm BB, Fuxe K. A2a/D2 receptor interactions are not observed in COS-7 cells transiently transfected with dopamine D2 and adenosine A2a receptor cDNA. Biochemical Pharmacology. 48: 2043-7. PMID 7802693 DOI: 10.1016/0006-2952(94)90503-7  1
1994 Adén U, Bona E, Hagberg H, Fredholm BB. Changes in c-fos mRNA in the neonatal rat brain following hypoxic ischemia. Neuroscience Letters. 180: 91-5. PMID 7700600  0.36
1994 Schubert P, Rudolphi KA, Fredholm BB, Nakamura Y. Modulation of nerve and glial function by adenosine--role in the development of ischemic damage. The International Journal of Biochemistry. 26: 1227-36. PMID 7531656 DOI: 10.1016/0020-711X(94)90092-2  1
1994 Johansson B, Lindström K, Fredholm BB. Differences in the regional and cellular localization of c-fos messenger RNA induced by amphetamine, cocaine and caffeine in the rat. Neuroscience. 59: 837-49. PMID 7520134  0.8
1993 Johansson B, Ahlberg S, van der Ploeg I, Brené S, Lindefors N, Persson H, Fredholm BB. Effect of long term caffeine treatment on A1 and A2 adenosine receptor binding and on mRNA levels in rat brain. Naunyn-Schmiedeberg's Archives of Pharmacology. 347: 407-14. PMID 8510768 DOI: 10.1007/BF00165391  1
1993 Fredholm BB, Gerwins P, Johansson B, Parkinson FE, van der Ploeg I. Signalling via G-protein coupled receptors--using adenosine receptors as an example. Drug Design and Discovery. 9: 189-97. PMID 8400002  1
1993 Lloyd HG, Lindström K, Fredholm BB. Intracellular formation and release of adenosine from rat hippocampal slices evoked by electrical stimulation or energy depletion. Neurochemistry International. 23: 173-85. PMID 8369741  0.36
1993 Georgiev V, Johansson B, Fredholm BB. Long-term caffeine treatment leads to a decreased susceptibility to NMDA-induced clonic seizures in mice without changes in adenosine A1 receptor number. Brain Research. 612: 271-7. PMID 8330205  0.8
1993 Johansson B, Georgiev V, Parkinson FE, Fredholm BB. The binding of the adenosine A2 receptor selective agonist [3H]CGS 21680 to rat cortex differs from its binding to rat striatum. European Journal of Pharmacology. 247: 103-10. PMID 8281998 DOI: 10.1016/0922-4106(93)90066-I  1
1993 Dunér-Engström M, Fredholm BB. Breakdown of membrane choline-phospholipids induced by endogenous and exogenous muscarinic agonist is potentiated by VIP in rat submandibular gland. Acta Physiologica Scandinavica. 149: 41-9. PMID 8237421 DOI: 10.1111/j.1748-1716.1993.tb09590.x  0.56
1993 Johansson B, Herrera-Marschitz M, Svenningson P, Fredholm BB. Caffeine-induced expression of the proto-oncogene c-fos in rat striatum is increased after dopamine denervation. Acta Physiologica Scandinavica. 149: 527-9. PMID 8128903 DOI: 10.1111/j.1748-1716.1993.tb09651.x  1
1993 Jin S, Johansson B, Fredholm BB. Effects of adenosine A1 and A2 receptor activation on electrically evoked dopamine and acetylcholine release from rat striatal slices. The Journal of Pharmacology and Experimental Therapeutics. 267: 801-8. PMID 7902434  0.8
1993 Altiok N, Fredholm BB. Bradykinin inhibits cyclic AMP accumulation in D384-human astrocytoma cells via a calcium-dependent inhibition of adenylyl cyclase. Cellular Signalling. 5: 279-88. PMID 7688545  0.6
1992 Parkinson FE, Fredholm BB. Magnesium-dependent enhancement of endogenous agonist binding to A1 adenosine receptors: a complicating factor in quantitative autoradiography. Journal of Neurochemistry. 58: 941-50. PMID 1738001  1
1992 Fredholm BB, Fastbom J, Kvanta A, Gerwins P, Parkinson F. Further evidence that propentofylline (HWA 285) influences both adenosine receptors and adenosine transport. Fundamental & Clinical Pharmacology. 6: 99-111. PMID 1628877  0.48
1992 van der Ploeg I, Parkinson FE, Fredholm BB. Effect of pertussis toxin on radioligand binding to rat brain adenosine A1 receptors. Journal of Neurochemistry. 58: 1221-9. PMID 1548460  1
1992 Kvanta A, Kontny E, Jondal M, Okret S, Fredholm BB. Mitogen stimulation of T-cells increases c-Fos and c-Jun protein levels, AP-1 binding and AP-1 transcriptional activity. Cellular Signalling. 4: 275-86. PMID 1510878  0.32
1992 Johansson B, Svenningsson P, Adén U, Lindström K, Fredholm BB. Evidence that the increase in striatal c-fos following acute high-dose caffeine is not due to direct interaction with striatal adenosine receptors. Acta Physiologica Scandinavica. 146: 539-41. PMID 1492572 DOI: 10.1111/j.1748-1716.1992.tb09461.x  1
1992 Ferré S, Fuxe K, von Euler G, Johansson B, Fredholm BB. Adenosine-dopamine interactions in the brain. Neuroscience. 51: 501-12. PMID 1488111  0.96
1992 Rudolphi KA, Schubert P, Parkinson FE, Fredholm BB. Adenosine and brain ischemia. Cerebrovascular and Brain Metabolism Reviews. 4: 346-69. PMID 1486019  1
1992 Johansson B, Parkinson FE, Fredholm BB. Effects of mono- and divalent ions on the binding of the adenosine analogue CGS 21680 to adenosine A2 receptors in rat striatum. Biochemical Pharmacology. 44: 2365-70. PMID 1472101 DOI: 10.1016/0006-2952(92)90681-8  1
1992 Meana JJ, Johansson B, Herrera-Marschitz M, O'Connor WT, Goiny M, Parkinson FE, Fredholm BB, Ungerstedt U. Effect of the neurotoxin AF64A on intrinsic and extrinsic neuronal systems of rat neostriatum measured by in vivo microdialysis. Brain Research. 596: 65-72. PMID 1361419 DOI: 10.1016/0006-8993(92)91533-K  0.48
1992 Dunér-Engström M, Larsson O, Fredholm BB, Lundblad L, Fahrenkrug J, Lundberg JM. Effects of acute and long-term atropine treatment on levels, release and response to VIP and PHI in the submandibular gland of cat and rat. Acta Physiologica Scandinavica. 146: 357-67. PMID 1336298 DOI: 10.1111/j.1748-1716.1992.tb09430.x  1
1992 Kontny E, Kvanta A, Fredholm BB. Activation of protein kinase C and elevation of cAMP interact synergistically to raise c-Fos and AP-1 activity in Jurkat cells. European Journal of Pharmacology. 227: 333-8. PMID 1335418  0.32
1992 Friedman WJ, Altiok N, Fredholm BB, Persson H. Mechanisms of nerve growth factor mRNA regulation by interleukin-1 beta in hippocampal cultures: role of second messengers. Journal of Neuroscience Research. 33: 37-46. PMID 1333537 DOI: 10.1002/jnr.490330106  1
1992 Balmforth AJ, Parkinson FE, Altiok N, Fredholm BB. Identification of a B2-bradykinin receptor linked to phospholipase C and inhibition of dopamine stimulated cyclic AMP accumulation in the human astrocytoma cell line D384. Naunyn-Schmiedeberg's Archives of Pharmacology. 346: 303-10. PMID 1328896 DOI: 10.1007/BF00173543  1
1992 Gerwins P, Fredholm BB. Stimulation of adenosine A1 receptors and bradykinin receptors, which act via different G proteins, synergistically raises inositol 1,4,5-trisphosphate and intracellular free calcium in DDT1 MF-2 smooth muscle cells. Proceedings of the National Academy of Sciences of the United States of America. 89: 7330-4. PMID 1323831  0.44
1992 Gerwins P, Fredholm BB. ATP and its metabolite adenosine act synergistically to mobilize intracellular calcium via the formation of inositol 1,4,5-trisphosphate in a smooth muscle cell line. The Journal of Biological Chemistry. 267: 16081-7. PMID 1322890  0.44
1992 Altiok N, Balmforth AJ, Fredholm BB. Adenosine receptor-induced cAMP changes in D384 astrocytoma cells and the effect of bradykinin thereon. Acta Physiologica Scandinavica. 144: 55-63. PMID 1317654 DOI: 10.1111/j.1748-1716.1992.tb09267.x  0.6
1992 Rudolphi KA, Schubert P, Parkinson FE, Fredholm BB. Neuroprotective role of adenosine in cerebral ischaemia. Trends in Pharmacological Sciences. 13: 439-45. PMID 1293870 DOI: 10.1016/0165-6147(92)90141-R  1
1992 Altiok N, Fredholm BB. Bradykinin inhibition of cyclic AMP accumulation in D384 astrocytoma cells. Evidence against a role of cyclic GMP. Neurochemistry International. 21: 209-13. PMID 1284620  0.6
1991 von Euler G, van der Ploeg I, Fredholm BB, Fuxe K. Neurotensin decreases the affinity of dopamine D2 agonist binding by a G protein-independent mechanism. Journal of Neurochemistry. 56: 178-83. PMID 1824779  0.96
1991 van der Ploeg I, Cintra A, Altiok N, Askelöf P, Fuxe K, Fredholm BB. Limited distribution of pertussis toxin in rat brain after injection into the lateral cerebral ventricles. Neuroscience. 44: 205-14. PMID 1770997  0.96
1991 Parkinson FE, Fredholm BB. Effects of propentofylline on adenosine A1 and A2 receptors and nitrobenzylthioinosine-sensitive nucleoside transporters: quantitative autoradiographic analysis. European Journal of Pharmacology. 202: 361-6. PMID 1748157 DOI: 10.1016/0014-2999(91)90279-Y  1
1991 Rorsman P, Fredholm BB. [Ion channels--the molecular background of neural transmission]. LäKartidningen. 88: 2868-77. PMID 1716716  1
1991 Ferre S, von Euler G, Johansson B, Fredholm BB, Fuxe K. Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranes. Proceedings of the National Academy of Sciences of the United States of America. 88: 7238-41. PMID 1678519  0.96
1991 van der Ploeg I, Altiok N, Kvanta A, Nordstedt C, Fredholm BB. Role of a pertussis toxin sensitive G-protein in mediating the effects of phorbol esters on receptor activated cyclic AMP accumulation in Jurkat cells. Naunyn-Schmiedeberg's Archives of Pharmacology. 344: 611-7. PMID 1667331  0.64
1991 Gerwins P, Fredholm BB. Glucocorticoid receptor activation leads to up-regulation of adenosine A1 receptors and down-regulation of adenosine A2 responses in DDT1 MF-2 smooth muscle cells. Molecular Pharmacology. 40: 149-55. PMID 1652051  0.44
1990 Dux E, Fastbom J, Ungerstedt U, Rudolphi K, Fredholm BB. Protective effect of adenosine and a novel xanthine derivative propentofylline on the cell damage after bilateral carotid occlusion in the gerbil hippocampus. Brain Research. 516: 248-56. PMID 2364291  0.48
1989 Von Euler G, Fuxe K, Van der Ploeg I, Fredholm BB, Agnati LF. Pertussis toxin treatment counteracts intramembrane interactions between neuropeptide Y receptors and alpha 2-adrenoceptors. European Journal of Pharmacology. 172: 435-41. PMID 2558898  0.96
1989 Fuxe K, von Euler G, van der Ploeg I, Fredholm BB, Agnati LF. Pertussis toxin treatment counteracts the cardiovascular effects of neuropeptide Y and clonidine in the awake unrestrained rat. Neuroscience Letters. 101: 337-41. PMID 2505200  0.96
1988 Lundberg JM, Hemsén A, Rudehill A, Härfstrand A, Larsson O, Sollevi A, Saria A, Hökfelt T, Fuxe K, Fredholm BB. Neuropeptide Y- and alpha-adrenergic receptors in pig spleen: localization, binding characteristics, cyclic AMP effects and functional responses in control and denervated animals. Neuroscience. 24: 659-72. PMID 2834666  1
1988 Lundberg JM, Hemsén A, Larsson O, Rudehill A, Saria A, Fredholm BB. Neuropeptide Y receptor in pig spleen: binding characteristics, reduction of cyclic AMP formation and calcium antagonist inhibition of vasoconstriction. European Journal of Pharmacology. 145: 21-9. PMID 2832184  1
1986 Dunér-Engström M, Fredholm BB, Larsson O, Lundberg JM, Saria A. Autonomic mechanisms underlying capsaicin induced oral sensations and salivation in man. The Journal of Physiology. 373: 87-96. PMID 2427699  1
1986 Larsson O, Dunér-Engström M, Lundberg JM, Fredholm BB, Anggård A. Effects of VIP, PHM and substance P on blood vessels and secretory elements of the human submandibular gland. Regulatory Peptides. 13: 319-26. PMID 2422707  1
1984 Lundberg JM, Hua Y, Fredholm BB. Capsaicin-induced stimulation of the guinea-pig atrium. Involvement of a novel sensory transmitter or a direct action on myocytes? Naunyn-Schmiedeberg's Archives of Pharmacology. 325: 176-82. PMID 6201751 DOI: 10.1007/BF00506198  1
1983 Fredholm BB, Herrera-Marschitz M, Jonzon B, Lindström K, Ungerstedt U. On the mechanism by which methylxanthines enhance apomorphine-induced rotation behaviour in the rat. Pharmacology, Biochemistry, and Behavior. 19: 535-41. PMID 6634904 DOI: 10.1016/0091-3057(83)90131-4  1
1982 Zetterström T, Vernet L, Ungerstedt U, Tossman U, Jonzon B, Fredholm BB. Purine levels in the intact rat brain. Studies with an implanted perfused hollow fibre. Neuroscience Letters. 29: 111-5. PMID 7088412  0.48
1982 Fredholm BB, Lundberg JM. VIP-induced cyclic AMP formation in the cat submandibular gland. Potentiation by carbacholine. Acta Physiologica Scandinavica. 114: 157-9. PMID 6291326 DOI: 10.1111/j.1748-1716.1982.tb06966.x  1
1982 Enyedi P, Fredholm BB, Lundberg JM, Anggård A. Carbachol potentiates the cyclic AMP-stimulating effect of VIP in cat submandibular gland. European Journal of Pharmacology. 79: 139-43. PMID 6177536  1
1978 Fuxe K, Fredholm BB, Agnati LF, Corrodi H. Dopamine receptors and ergot drugs. Evidence that an ergolene derivative is a differential agonist at subcortical limbic dopamine receptors. Brain Research. 146: 295-311. PMID 647392  0.96
1978 Fuxe K, Fredholm BB, Agnati LF, Ogren SO, Everitt BJ, Jonsson G, Gustafsson JA. Interaction of ergot drugs with central monoamine systems. Evidence for a high potential in the treatment of mental and neurological disorders. Pharmacology. 16: 99-134. PMID 643908  0.96
1978 Fuxe K, Fredholm BB, Ogren SO, Agnati LF, Hökfelt T, Gustafsson JA. Ergot drugs and central monoaminergic mechanisms: a histochemical, biochemical and behavioral analysis. Federation Proceedings. 37: 2181-91. PMID 350633  0.96
1978 Fuxe K, Fredholm BB, Ogren SO, Agnati LF, Hökfelt T, Gustafsson JA. Pharmacological and biochemical evidence for the dopamine agonistic effect of bromocriptine. Acta Endocrinologica. Supplementum. 216: 27-56. PMID 347864  0.96
1977 Belfrage E, Fredholm BB, Rosell S. Effect of catechol-O-methyl-transferase (COMT) inhibition on the vascular and metabolic responses to noradrenaline, isoprenaline and sympathetic nerve stimulation in canine subcutaneous adipose tissue. Naunyn-Schmiedeberg's Archives of Pharmacology. 300: 11-7. PMID 593427 DOI: 10.1007/BF00505074  1
1976 Fredholm BB, Fuxe K, Agnati L. Effect of some phosphodiesterase inhibitors on central dopamine mechanisms. European Journal of Pharmacology. 38: 31-8. PMID 182507  0.96
1971 Ballard K, Fredholm BB, Meng HC, Rosell S. Heparin-induced release of lipase activity from perfused canine subcutaneous adipose tissue. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 137: 1490-3. PMID 5138478 DOI: 10.3181/00379727-137-35816  1
1970 Fredholm BB, Rosell S. Effects of prostaglandin E1 in canine subcutaneous adipose tissue in situ. Acta Physiologica Scandinavica. 80: 450-8. PMID 5493808 DOI: 10.1111/j.1748-1716.1970.tb04813.x  1
1970 Fredholm BB, Rosell S. Fate of 3H-noradrenaline in canine subcutaneous adipose tissue. Acta Physiologica Scandinavica. 80: 404-11. PMID 5486466 DOI: 10.1111/j.1748-1716.1970.tb04804.x  1
1970 Fredholm BB, Oberg B, Rosell S. Effects of vasoactive drugs on circulation in canine subcutaneous adipose tissue. Acta Physiologica Scandinavica. 79: 564-74. PMID 5472122 DOI: 10.1111/j.1748-1716.1970.tb04759.x  1
1970 Fredholm BB, Rosell S, Strandberg K. Release of prostaglandin-like material from canine subcutaneous adipose tissue by nerve stimulation. Acta Physiologica Scandinavica. 79: 18A-19A. PMID 5454886  1
1969 Fredholm BB, Linde B, Oberg B, Rosell S. Studies on the capillary exchange function in canine subcutaneous adipose tissue. Bibliotheca Anatomica. 10: 241-3. PMID 5407371  1
1968 Fredholm BB, Meng HC, Oberg B, Rosell S. Vascular and metabolic effects of histamine and compound 48/80 in subcutaneous adipose tissue. British Journal of Pharmacology. 34: 197P-198P. PMID 5676007  1
1968 Fredholm BB, Meng HC, Rosell S. Release of free fatty acids from canine subcutaneous adipose tissue by histamine and compound 48-80. Life Sciences. 7: 1209-15. PMID 4181282  1
1967 Fredholm BB, Oberg B, Rosell S. Vascular reactions in canine subcutaneous adipose tissue following prostaglandin E1 (PGE1). Acta Pharmacologica Et Toxicologica. 25: Suppl 4:28. PMID 4230880  1
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