☰

David A. Orlando, Ph.D. - Publications

Affiliations: 
2009 Computational Biology and Bioinformatics Duke University, Durham, NC 
Area:
Bioinformatics, Genetics
Tree Info Similar researchers PubMed Report error

40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Campione SA, Kelliher CM, Orlando DA, Tran TQ, Haase SB. Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons. Journal of Visualized Experiments : Jove. PMID 37358275 DOI: 10.3791/65466  0.765
2019 Hu S, Marineau JJ, Rajagopal N, Hamman KB, Choi YJ, Schmidt DR, Ke N, Johannessen L, Bradley MJ, Orlando DA, Alnemy SR, Ren Y, Ciblat S, Winter DK, Kabro A, et al. Discovery and characterization of SY-1365, a selective, covalent inhibitor of CDK7. Cancer Research. PMID 31064851 DOI: 10.1158/0008-5472.Can-19-0119  0.427
2019 Hu S, Marineau J, Hamman K, Bradley M, Savinainen A, Alnemy S, Rajagopal N, Orlando D, Chuaqui C, Olson E. Abstract 4421: SY-5609, an orally available selective CDK7 inhibitor demonstrates broad anti-tumor activity in vivo Cancer Research. 79: 4421-4421. DOI: 10.1158/1538-7445.Sabcs18-4421  0.353
2019 Ke N, Johannessen L, Rajagopal N, Orlando D, Carulli J, Hodgson G. Abstract 4409: Prospective identification of RB pathway alterations predict response to SY-1365, a selective CDK7 inhibitor, in a panel of high-grade serous ovarian cancer (HGSOC) patient derived xenograft (PDX) models Cancer Research. 79: 4409-4409. DOI: 10.1158/1538-7445.Sabcs18-4409  0.312
2018 Guenther M, Lambert A, Chen M, Fiore C, Eaton M, Orlando D, Bierie B, Weinberg R, Fritz C, Olson E. Abstract P2-04-03: Epigenomic analysis of cancer stem cell (CSC)-enriched triple-negative breast cancer (TNBC) populations reveals gene regulatory circuitry and novel tumor cell vulnerabilities Cancer Research. 78. DOI: 10.1158/1538-7445.Sabcs17-P2-04-03  0.407
2018 Rajagopal N, Hodgson G, Hu S, McKeown M, Bush A, Fritz C, Orlando D, Olson E, Tomaso Ed. Abstract P1-09-08:BCL2L1(BCL-XL) expression and MYC super-enhancer positivity predict sensitivity to the covalent CDK7 inhibitor SY-1365 in triple negative breast cancer (TNBC) cell lines Cancer Research. 78. DOI: 10.1158/1538-7445.Sabcs17-P1-09-08  0.404
2018 Konstantinopoulos PA, Hodgson G, Rajagopal N, Johannessen L, Liu JF, Kirschmeier PT, Zhou S, Tran CA, Orlando D, Fritz C, Tomaso Ed, Matulonis UA. Abstract 1525: SY-1365, a selective CDK7 inhibitor, exhibits potent antitumor activity against ovarian cancer models in vitro and in vivo Cancer Research. 78: 1525-1525. DOI: 10.1158/1538-7445.Am2018-1525  0.349
2017 McKeown MR, Corces MR, Eaton ML, Fiore C, Lee E, Lopez JT, Chen MW, Smith D, Chan SM, Koenig JL, Austgen K, Guenther MG, Orlando DA, Lovén J, Fritz CC, et al. Super-Enhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist. Cancer Discovery. PMID 28729405 DOI: 10.1158/2159-8290.Cd-17-0399  0.364
2017 Hu S, Ke N, Ren Y, Miljovska S, Rajagopal N, McKeown M, Orlando D, Sprott K, Choi YJ, Olson E, Fritz CC. Abstract 1151: SY-1365, a potent and selective CDK7 inhibitor, exhibits promising anti-tumor activity in multiple preclinical models of aggressive solid tumors Cancer Research. 77: 1151-1151. DOI: 10.1158/1538-7445.Am2017-1151  0.414
2017 Bradley M, Marineau J, Choi Y, Hamman K, Malojcic G, Orlando D, Ren Y, Ke N, Hu S, Olson E, Fritz C, Roberts C. Abstract 1143: Targeting the transcriptional kinases CDK12 and CDK13 in breast and ovarian cancer Cancer Research. 77: 1143-1143. DOI: 10.1158/1538-7445.Am2017-1143  0.392
2016 Hu S, Ke N, Ren Y, Lopez J, Miljovska S, Orlando D, Schmidt D, Bradley M, Sprott K, Olson E, Fritz CC, Choi YJ. Abstract 4820: Selective CDK7 inhibitors suppress super enhancer-genes, induce massive apoptosis in acute myeloid leukemia and demonstrate durablein vivoefficacy Cancer Research. 76: 4820-4820. DOI: 10.1158/1538-7445.Am2016-4820  0.431
2015 Orlando DA, McKeown MR, Chen MW, Collins C, Guenther MG, Fritz CC. Abstract A1-69: Predicting drug response by profiling the epigenome: Super-enhancers as biomarkers Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-A1-69  0.326
2015 Guenther MG, Orlando DA, Eaton ML, Collins CA, Chen MW, Solanki S, Loven J, Fritz CC, Olson ER. Abstract P1-06-04: Super-enhancer analysis defines breast cancer subtype and identifies tumor dependencies Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P1-06-04  0.364
2015 Collins C, Chen MW, Eaton M, Orlando D, McKeown M, Fritz C, Olson E, Guenther M. Abstract 3837: Super-enhancers define breast cancer subclasses and identify novel tumor cell vulnerabilities Cancer Research. 75: 3837-3837. DOI: 10.1158/1538-7445.Am2015-3837  0.353
2014 Orlando DA, Chen MW, Brown VE, Solanki S, Choi YJ, Olson ER, Fritz CC, Bradner JE, Guenther MG. Quantitative ChIP-Seq normalization reveals global modulation of the epigenome. Cell Reports. 9: 1163-70. PMID 25437568 DOI: 10.1016/J.Celrep.2014.10.018  0.36
2013 Dowen JM, Bilodeau S, Orlando DA, Hübner MR, Abraham BJ, Spector DL, Young RA. Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements. Stem Cell Reports. 1: 371-8. PMID 24286025 DOI: 10.1016/J.Stemcr.2013.09.002  0.403
2013 Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok SM, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, et al. Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell. 13: 446-58. PMID 24094325 DOI: 10.1016/J.Stem.2013.09.001  0.343
2013 Lovén J, Hoke HA, Lin CY, Lau A, Orlando DA, Vakoc CR, Bradner JE, Lee TI, Young RA. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell. 153: 320-34. PMID 23582323 DOI: 10.1016/J.Cell.2013.03.036  0.393
2013 Whyte WA, Orlando DA, Hnisz D, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI, Young RA. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell. 153: 307-19. PMID 23582322 DOI: 10.1016/J.Cell.2013.03.035  0.482
2013 Guo X, Bernard A, Orlando DA, Haase SB, Hartemink AJ. Branching process deconvolution algorithm reveals a detailed cell-cycle transcription program. Proceedings of the National Academy of Sciences of the United States of America. 110: E968-77. PMID 23388635 DOI: 10.1073/Pnas.1120991110  0.738
2013 Sigova AA, Mullen AC, Molinie B, Gupta S, Orlando DA, Guenther MG, Almada AE, Lin C, Sharp PA, Giallourakis CC, Young RA. Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 2876-81. PMID 23382218 DOI: 10.1073/Pnas.1221904110  0.575
2013 Simmons Kovacs LA, Mayhew MB, Orlando DA, Jin Y, Li Q, Huang C, Reed SI, Mukherjee S, Haase SB. Errata to Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network [Molecular Cell, 45 (2012) 669-679] Molecular Cell. 49: 1177-1179. DOI: 10.1016/j.molcel.2013.03.007  0.788
2012 Lovén J, Orlando DA, Sigova AA, Lin CY, Rahl PB, Burge CB, Levens DL, Lee TI, Young RA. Revisiting global gene expression analysis. Cell. 151: 476-82. PMID 23101621 DOI: 10.1016/J.Cell.2012.10.012  0.4
2012 Orlando DA, Guenther MG, Frampton GM, Young RA. CpG island structure and trithorax/polycomb chromatin domains in human cells. Genomics. 100: 320-6. PMID 22819920 DOI: 10.1016/J.Ygeno.2012.07.006  0.352
2012 Simmons Kovacs LA, Mayhew MB, Orlando DA, Jin Y, Li Q, Huang C, Reed SI, Mukherjee S, Haase SB. Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network. Molecular Cell. 45: 669-79. PMID 22306294 DOI: 10.1016/J.Molcel.2011.12.033  0.692
2012 Whyte WA, Bilodeau S, Orlando DA, Hoke HA, Frampton GM, Foster CT, Cowley SM, Young RA. Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature. 482: 221-5. PMID 22297846 DOI: 10.1038/Nature10805  0.394
2011 Mullen AC, Orlando DA, Newman JJ, Lovén J, Kumar RM, Bilodeau S, Reddy J, Guenther MG, DeKoter RP, Young RA. Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell. 147: 565-76. PMID 22036565 DOI: 10.1016/J.Cell.2011.08.050  0.412
2011 Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, Fritsch L, Lin WM, Hollmann TJ, Ferré F, Bourque C, Burke CJ, Turner L, Uong A, Johnson LA, et al. The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature. 471: 513-7. PMID 21430779 DOI: 10.1038/Nature09806  0.348
2011 Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, Van Berkum NL, Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J, Young RA. Mediator and cohesin connect gene expression and chromatin architecture (Nature (2010) 467 (430-435)) Nature. 472: 247. DOI: 10.1038/Nature09930  0.394
2010 Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL, Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J, Young RA. Mediator and cohesin connect gene expression and chromatin architecture. Nature. 467: 430-5. PMID 20720539 DOI: 10.1038/nature09380  0.379
2010 Orlando DA, Brady SM, Fink TM, Benfey PN, Ahnert SE. Detecting separate time scales in genetic expression data. Bmc Genomics. 11: 381. PMID 20565716 DOI: 10.1186/1471-2164-11-381  0.677
2009 Orlando DA, Iversen ES, Hartemink AJ, Haase SB. A branching process model for flow cytometry and budding index measurements in cell synchrony experiments. The Annals of Applied Statistics. 3: 1521-1541. PMID 21853014 DOI: 10.1214/09-Aoas264  0.668
2009 Cartwright DA, Brady SM, Orlando DA, Sturmfels B, Benfey PN. Reconstructing spatiotemporal gene expression data from partial observations. Bioinformatics (Oxford, England). 25: 2581-7. PMID 19608707 DOI: 10.1093/Bioinformatics/Btp437  0.713
2009 Orlando DA, Brady SM, Koch JD, Dinneny JR, Benfey PN. Manipulating large-scale Arabidopsis microarray expression data: identifying dominant expression patterns and biological process enrichment. Methods in Molecular Biology (Clifton, N.J.). 553: 57-77. PMID 19588101 DOI: 10.1007/978-1-60327-563-7_4  0.779
2009 Crutchley J, King KM, Keaton MA, Szkotnicki L, Orlando DA, Zyla TR, Bardes ES, Lew DJ. Molecular dissection of the checkpoint kinase Hsl1p. Molecular Biology of the Cell. 20: 1926-36. PMID 19211841 DOI: 10.1091/Mbc.E08-08-0848  0.392
2008 Simmons Kovacs LA, Orlando DA, Haase SB. Transcription networks and cyclin/CDKs: the yin and yang of cell cycle oscillators. Cell Cycle (Georgetown, Tex.). 7: 2626-9. PMID 18758238 DOI: 10.4161/Cc.7.17.6515  0.757
2008 Chaudhuri B, Hörmann F, Lalonde S, Brady SM, Orlando DA, Benfey P, Frommer WB. Protonophore- and pH-insensitive glucose and sucrose accumulation detected by FRET nanosensors in Arabidopsis root tips. The Plant Journal : For Cell and Molecular Biology. 56: 948-62. PMID 18702670 DOI: 10.1111/J.1365-313X.2008.03652.X  0.639
2008 Orlando DA, Lin CY, Bernard A, Wang JY, Socolar JE, Iversen ES, Hartemink AJ, Haase SB. Global control of cell-cycle transcription by coupled CDK and network oscillators. Nature. 453: 944-7. PMID 18463633 DOI: 10.1038/Nature06955  0.79
2007 Brady SM, Orlando DA, Lee JY, Wang JY, Koch J, Dinneny JR, Mace D, Ohler U, Benfey PN. A high-resolution root spatiotemporal map reveals dominant expression patterns. Science (New York, N.Y.). 318: 801-6. PMID 17975066 DOI: 10.1126/Science.1146265  0.778
2007 Orlando DA, Lin CY, Bernard A, Iversen ES, Hartemink AJ, Haase SB. A probabilistic model for cell cycle distributions in synchrony experiments. Cell Cycle (Georgetown, Tex.). 6: 478-88. PMID 17329975 DOI: 10.4161/Cc.6.4.3859  0.689
Show low-probability matches.