Philippe Lefebvre - Publications

INSERM, Rennes, Bretagne, France 
Nuclear receptors, metabolism

133 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Haas JT, Vonghia L, Mogilenko DA, Verrijken A, Molendi-Coste O, Fleury S, Deprince A, Nikitin A, Woitrain E, Ducrocq-Geoffroy L, Pic S, Derudas B, Dehondt H, Gheeraert C, Van Gaal L, ... ... Lefebvre P, et al. Transcriptional Network Analysis Implicates Altered Hepatic Immune Function in NASH development and resolution. Nature Metabolism. 1: 604-614. PMID 31701087 DOI: 10.1038/s42255-019-0076-1  0.48
2019 Margerie D, Lefebvre P, Raverdy V, Schwahn U, Ruetten H, Larsen P, Duhamel A, Labreuche J, Thuillier D, Derudas B, Gheeraert C, Dehondt H, Dhalluin Q, Alexandre J, Caiazzo R, et al. Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients. Bmc Medical Genomics. 12: 80. PMID 31159817 DOI: 10.1186/s12920-019-0536-1  0.48
2019 Liang N, Damdimopoulos A, Goñi S, Huang Z, Vedin LL, Jakobsson T, Giudici M, Ahmed O, Pedrelli M, Barilla S, Alzaid F, Mendoza A, Schröder T, Kuiper R, Parini P, ... ... Lefebvre P, et al. Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα. Nature Communications. 10: 1684. PMID 30975991 DOI: 10.1038/s41467-019-09524-z  0.48
2018 Hering Y, Berthier A, Duez H, Lefebvre P, Deprez B, Gribbon P, Wolf M, Reinshagen J, Halley F, Hannemann J, Böger R, Staels B, Gul S. Development and implementation of a cell-based assay to discover agonists of the nuclear receptor REV-ERBα. Journal of Biological Methods. 5: e94. PMID 31453244 DOI: 10.14440/jbm.2018.244  0.48
2018 Berthier A, Vinod M, Porez G, Steenackers A, Alexandre J, Yamakawa N, Gheeraert C, Ploton M, Maréchal X, Dubois-Chevalier J, Hovasse A, Schaeffer-Reiss C, Cianférani S, Rolando C, Bray F, ... ... Lefebvre P, et al. Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBα complex. Proceedings of the National Academy of Sciences of the United States of America. PMID 30397120 DOI: 10.1073/pnas.1805397115  0.48
2018 Wargny M, Ducluzeau PH, Petit JM, Le May C, Smati S, Arnaud L, Pichelin M, Bouillet B, Lannes A, Blanchet O, Lefebvre P, Francque S, Van Gaal L, Staels B, Vergès B, et al. Circulating PCSK9 levels are not associated with the severity of hepatic steatosis and NASH in a high-risk population. Atherosclerosis. 278: 82-90. PMID 30261472 DOI: 10.1016/j.atherosclerosis.2018.09.008  0.48
2018 Bobowski-Gerard M, Zummo FP, Staels B, Lefebvre P, Eeckhoute J. Retinoids Issued from Hepatic Stellate Cell Lipid Droplet Loss as Potential Signaling Molecules Orchestrating a Multicellular Liver Injury Response. Cells. 7. PMID 30217095 DOI: 10.3390/cells7090137  0.48
2018 Ploton M, Mazuy C, Gheeraert C, Dubois V, Berthier A, Dubois-Chevalier J, Maréchal X, Bantubungi-Blum K, Diemer H, Cianférani S, Strub JM, Helleboid-Chapman A, Eeckhoute J, Staels B, Lefebvre P. The Nuclear Bile Acid Receptor FXR is a PKA- and FOXA2-Sensitive Activator of Fasting Hepatic Gluconeogenesis. Journal of Hepatology. PMID 29981427 DOI: 10.1016/j.jhep.2018.06.022  0.48
2018 Montaigne D, Coisne A, Marechal X, Lefebvre P, Staels B. Daytime variations in perioperative myocardial injury - Authors' reply. Lancet (London, England). 391: 2106. PMID 29856343 DOI: 10.1016/S0140-6736(18)30758-X  0.48
2017 Montaigne D, Marechal X, Modine T, Coisne A, Mouton S, Fayad G, Ninni S, Klein C, Ortmans S, Seunes C, Potelle C, Berthier A, Gheeraert C, Piveteau C, Deprez R, ... ... Lefebvre P, et al. Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study. Lancet (London, England). PMID 29107324 DOI: 10.1016/S0140-6736(17)32132-3  0.48
2017 Dubois-Chevalier J, Mazrooei P, Lupien M, Staels B, Lefebvre P, Eeckhoute J. Organizing combinatorial transcription factor recruitment at cis-regulatory modules. Transcription. 1-15. PMID 29105538 DOI: 10.1080/21541264.2017.1394424  0.48
2017 Firmin FF, Oger F, Gheeraert C, Dubois-Chevalier J, Vercoutter-Edouart AS, Alzaid F, Mazuy C, Dehondt H, Alexandre J, Derudas B, Dhalluin Q, Ploton M, Berthier A, Woitrain E, Lefebvre T, ... ... Lefebvre P, et al. The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ. Scientific Reports. 7: 14087. PMID 29075020 DOI: 10.1038/s41598-017-14570-y  0.48
2017 Legry V, Francque S, Haas JT, Verrijken A, Caron S, Chávez-Talavera O, Vallez E, Vonghia L, Dirinck E, Verhaegen A, Kouach M, Lestavel S, Lefebvre P, Van Gaal L, Tailleux A, et al. Bile acid alterations are associated with insulin resistance, but not with NASH in obese subjects. The Journal of Clinical Endocrinology and Metabolism. PMID 28938455 DOI: 10.1210/jc.2017-01397  0.48
2017 Lefebvre P, Lalloyer F, Baugé E, Pawlak M, Gheeraert C, Dehondt H, Vanhoutte J, Woitrain E, Hennuyer N, Mazuy C, Bobowski-Gérard M, Zummo FP, Derudas B, Driessen A, Hubens G, et al. Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin. Jci Insight. 2. PMID 28679947 DOI: 10.1172/jci.insight.92264  0.48
2017 Dubois-Chevalier J, Dubois V, Dehondt H, Mazrooei P, Mazuy C, Sérandour AA, Gheeraert C, Penderia G, Baugé E, Derudas B, Hennuyer N, Paumelle R, Marot G, Carroll JS, Lupien M, ... ... Lefebvre P, et al. The logic of transcriptional regulator recruitment architecture at cis-regulatory modules controlling liver functions. Genome Research. PMID 28400425 DOI: 10.1101/gr.217075.116  0.48
2017 Dubois V, Eeckhoute J, Lefebvre P, Staels B. Distinct but complementary contributions of PPAR isotypes to energy homeostasis. The Journal of Clinical Investigation. 127: 1202-1214. PMID 28368286 DOI: 10.1172/JCI88894  0.48
2017 Chávez-Talavera O, Tailleux A, Lefebvre P, Staels B. Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia and NAFLD. Gastroenterology. PMID 28214524 DOI: 10.1053/j.gastro.2017.01.055  0.48
2017 Le-Guevel R, Oger F, Martinez-Jimenez CP, Bizot M, Gheeraert C, Firmin F, Ploton M, Kretova M, Palierne G, Staels B, Barath P, Talianidis I, Lefebvre P, Eeckhoute J, Salbert G. Inactivation of the nuclear orphan receptor COUP-TFII by small chemicals. Acs Chemical Biology. PMID 28059499 DOI: 10.1021/acschembio.6b00593  0.48
2016 van Moorsel D, Hansen J, Havekes B, Scheer FA, Jörgensen JA, Hoeks J, Schrauwen-Hinderling VB, Duez H, Lefebvre P, Schaper NC, Hesselink MK, Staels B, Schrauwen P. Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity. Molecular Metabolism. 5: 635-45. PMID 27656401 DOI: 10.1016/j.molmet.2016.06.012  0.48
2016 Gross B, Pawlak M, Lefebvre P, Staels B. PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD. Nature Reviews. Endocrinology. PMID 27636730 DOI: 10.1038/nrendo.2016.135  0.48
2016 Hennuyer N, Duplan I, Paquet C, Vanhoutte J, Woitrain E, Touche V, Colin S, Vallez E, Lestavel S, Lefebvre P, Staels B. The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis. Atherosclerosis. PMID 27108950 DOI: 10.1016/j.atherosclerosis.2016.03.003  0.48
2015 Trabelsi MS, Daoudi M, Prawitt J, Ducastel S, Touche V, Sayin SI, Perino A, Brighton CA, Sebti Y, Kluza J, Briand O, Dehondt H, Vallez E, Dorchies E, Baud G, ... ... Lefebvre P, et al. Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells. Nature Communications. 6: 7629. PMID 26134028 DOI: 10.1038/ncomms8629  0.48
2015 Pawlak M, Baugé E, Lalloyer F, Lefebvre P, Staels B. Ketone body therapy protects from lipotoxicity and acute liver failure upon Pparα-deficiency. Molecular Endocrinology (Baltimore, Md.). me20141383. PMID 26087172 DOI: 10.1210/me.2014-1383  0.48
2015 Fu X, Dong B, Tian Y, Lefebvre P, Meng Z, Wang X, Pattou F, Han W, Wang X, Lou F, Jove R, Staels B, Moore DD, Huang W. MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids. The Journal of Clinical Investigation. 125: 2497-509. PMID 25961460 DOI: 10.1172/JCI75438  0.48
2015 De Paoli F, Eeckhoute J, Copin C, Vanhoutte J, Duhem C, Derudas B, Dubois-Chevalier J, Colin S, Zawadzki C, Jude B, Haulon S, Lefebvre P, Staels B, Chinetti-Gbaguidi G. The neuron-derived orphan receptor 1 (NOR1) is induced upon human alternative macrophage polarization and stimulates the expression of markers of the M2 phenotype. Atherosclerosis. 241: 18-26. PMID 25941992 DOI: 10.1016/j.atherosclerosis.2015.04.798  0.68
2015 Lefebvre P, Staels B. SREBF2-embedded mir33 links the nuclear bile acid receptor FXR to cholesterol and lipoprotein metabolism. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 748-9. PMID 25810294 DOI: 10.1161/ATVBAHA.115.305317  0.48
2015 Francque S, Verrijken A, Caron S, Prawitt J, Paumelle R, Derudas B, Lefebvre P, Taskinen MR, Van Hul W, Mertens I, Hubens G, Van Marck E, Michielsen P, Van Gaal L, Staels B. PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis. Journal of Hepatology. 63: 164-73. PMID 25703085 DOI: 10.1016/j.jhep.2015.02.019  0.48
2015 Dubois-Chevalier J, Staels B, Lefebvre P, Eeckhoute J. The ubiquitous transcription factor CTCF promotes lineage-specific epigenomic remodeling and establishment of transcriptional networks driving cell differentiation. Nucleus (Austin, Tex.). 6: 15-8. PMID 25565413 DOI: 10.1080/19491034.2015.1004258  0.68
2015 Mazuy C, Helleboid A, Staels B, Lefebvre P. Nuclear bile acid signaling through the farnesoid X receptor. Cellular and Molecular Life Sciences : Cmls. 72: 1631-50. PMID 25511198 DOI: 10.1007/s00018-014-1805-y  0.68
2015 Pawlak M, Lefebvre P, Staels B. Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. Journal of Hepatology. 62: 720-33. PMID 25450203 DOI: 10.1016/j.jhep.2014.10.039  0.68
2014 Benhamed F, Filhoulaud G, Caron S, Lefebvre P, Staels B, Postic C. O-GlcNAcylation Links ChREBP and FXR to Glucose-Sensing. Frontiers in Endocrinology. 5: 230. PMID 25628602 DOI: 10.3389/fendo.2014.00230  0.68
2014 Dubois-Chevalier J, Oger F, Dehondt H, Firmin FF, Gheeraert C, Staels B, Lefebvre P, Eeckhoute J. A dynamic CTCF chromatin binding landscape promotes DNA hydroxymethylation and transcriptional induction of adipocyte differentiation. Nucleic Acids Research. 42: 10943-59. PMID 25183525 DOI: 10.1093/nar/gku780  0.48
2014 Pawlak M, Baugé E, Bourguet W, De Bosscher K, Lalloyer F, Tailleux A, Lebherz C, Lefebvre P, Staels B. The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice. Hepatology (Baltimore, Md.). 60: 1593-606. PMID 24995693 DOI: 10.1002/hep.27297  0.68
2014 Bicego A, Lejoly K, Maudoux A, Lefebvre P, Laureys S, Schweizer V, Diserens K, Faymonville ME, Vanhaudenhuyse A. [Swallowing in disorders of consciousness]. Revue Neurologique. 170: 630-41. PMID 24952924 DOI: 10.1016/j.neurol.2014.04.004  0.68
2014 Montaigne D, Marechal X, Coisne A, Debry N, Modine T, Fayad G, Potelle C, El Arid JM, Mouton S, Sebti Y, Duez H, Preau S, Remy-Jouet I, Zerimech F, Koussa M, ... ... Lefebvre P, et al. Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients. Circulation. 130: 554-64. PMID 24928681 DOI: 10.1161/CIRCULATIONAHA.113.008476  0.68
2014 Oger F, Gheeraert C, Mogilenko D, Benomar Y, Molendi-Coste O, Bouchaert E, Caron S, Dombrowicz D, Pattou F, Duez H, Eeckhoute J, Staels B, Lefebvre P. Cell-specific dysregulation of microRNA expression in obese white adipose tissue. The Journal of Clinical Endocrinology and Metabolism. 99: 2821-33. PMID 24758184 DOI: 10.1210/jc.2013-4259  0.68
2014 Lefebvre P, Staels B. DCo(H2)ding the metabolic functions of SIRT1 in the intestine. Gastroenterology. 146: 893-6. PMID 24566103 DOI: 10.1053/j.gastro.2014.02.020  0.68
2014 Lien F, Berthier A, Bouchaert E, Gheeraert C, Alexandre J, Porez G, Prawitt J, Dehondt H, Ploton M, Colin S, Lucas A, Patrice A, Pattou F, Diemer H, Van Dorsselaer A, ... ... Lefebvre P, et al. Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk. The Journal of Clinical Investigation. 124: 1037-51. PMID 24531544 DOI: 10.1172/JCI68815  0.68
2014 Lefebvre P, Staels B. Failing FXR expression in the liver links aging to hepatic steatosis. Journal of Hepatology. 60: 689-90. PMID 24418014 DOI: 10.1016/j.jhep.2014.01.001  0.68
2014 Oger F, Dubois-Chevalier J, Gheeraert C, Avner S, Durand E, Froguel P, Salbert G, Staels B, Lefebvre P, Eeckhoute J. Peroxisome proliferator-activated receptor γ regulates genes involved in insulin/insulin-like growth factor signaling and lipid metabolism during adipogenesis through functionally distinct enhancer classes. The Journal of Biological Chemistry. 289: 708-22. PMID 24288131 DOI: 10.1074/jbc.M113.526996  0.68
2014 Berrabah W, Aumercier P, Gheeraert C, Dehondt H, Bouchaert E, Alexandre J, Ploton M, Mazuy C, Caron S, Tailleux A, Eeckhoute J, Lefebvre T, Staels B, Lefebvre P. Glucose sensing O-GlcNAcylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR). Hepatology (Baltimore, Md.). 59: 2022-33. PMID 24037988 DOI: 10.1002/hep.26710  0.68
2014 Maudoux A, Lefebvre P. Tinnitus: Mechanisms induced from human functional neuroimaging studies Seminars in Hearing. 35: 131-144. DOI: 10.1055/s-0034-1372529  0.68
2013 Flajollet S, Staels B, Lefebvre P. Retinoids and nuclear retinoid receptors in white and brown adipose tissues: physiopathologic aspects. Hormone Molecular Biology and Clinical Investigation. 14: 75-86. PMID 25436722 DOI: 10.1515/hmbci-2013-0013  0.68
2013 Mazuy C, Ploton M, Eeckhoute J, Berrabah W, Staels B, Lefebvre P, Helleboid-Chapman A. Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic β-cells. Febs Letters. PMID 24512852 DOI: 10.1016/j.febslet.2013.10.024  0.68
2013 Mazuy C, Ploton M, Eeckhoute J, Berrabah W, Staels B, Lefebvre P, Helleboid-Chapman A. Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic β-cells. Febs Letters. 587: 3883-90. PMID 24396871  0.48
2013 Porez G, Gross B, Prawitt J, Gheeraert C, Berrabah W, Alexandre J, Staels B, Lefebvre P. The hepatic orosomucoid/α1-acid glycoprotein gene cluster is regulated by the nuclear bile acid receptor FXR. Endocrinology. 154: 3690-701. PMID 23861371 DOI: 10.1210/en.2013-1263  0.68
2013 Woldt E, Sebti Y, Solt LA, Duhem C, Lancel S, Eeckhoute J, Hesselink MK, Paquet C, Delhaye S, Shin Y, Kamenecka TM, Schaart G, Lefebvre P, Nevière R, Burris TP, et al. Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy. Nature Medicine. 19: 1039-46. PMID 23852339 DOI: 10.1038/nm.3213  0.68
2013 Flajollet S, Rachez C, Ploton M, Schulz C, Gallais R, Métivier R, Pawlak M, Leray A, Issulahi AA, Héliot L, Staels B, Salbert G, Lefebvre P. The elongation complex components BRD4 and MLLT3/AF9 are transcriptional coactivators of nuclear retinoid receptors. Plos One. 8: e64880. PMID 23762261 DOI: 10.1371/journal.pone.0064880  0.68
2013 Montaigne D, Marechal X, Lefebvre P, Modine T, Fayad G, Dehondt H, Hurt C, Coisne A, Koussa M, Remy-Jouet I, Zerimech F, Boulanger E, Lacroix D, Staels B, Neviere R. Mitochondrial dysfunction as an arrhythmogenic substrate: a translational proof-of-concept study in patients with metabolic syndrome in whom post-operative atrial fibrillation develops. Journal of the American College of Cardiology. 62: 1466-73. PMID 23644086 DOI: 10.1016/j.jacc.2013.03.061  0.68
2013 Caron S, Huaman Samanez C, Dehondt H, Ploton M, Briand O, Lien F, Dorchies E, Dumont J, Postic C, Cariou B, Lefebvre P, Staels B. Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes. Molecular and Cellular Biology. 33: 2202-11. PMID 23530060 DOI: 10.1128/MCB.01004-12  0.68
2013 El-Shazly AE, Doloriert HC, Bisig B, Lefebvre PP, Delvenne P, Jacobs N. Novel cooperation between CX3CL1 and CCL26 inducing NK cell chemotaxis via CX3CR1: a possible mechanism for NK cell infiltration of the allergic nasal tissue. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 43: 322-31. PMID 23414540 DOI: 10.1111/cea.12022  0.68
2013 El-Shazly AE, Begon DY, Kustermans G, Arafa M, Dortu E, Henket M, Lefebvre PP, Louis R, Delvenne P. Novel association between vasoactive intestinal peptide and CRTH2 receptor in recruiting eosinophils: a possible biochemical mechanism for allergic eosinophilic inflammation of the airways. The Journal of Biological Chemistry. 288: 1374-84. PMID 23168411 DOI: 10.1074/jbc.M112.422675  0.68
2012 Eeckhoute J, Oger F, Staels B, Lefebvre P. Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity. Ppar Research. 2012: 164140. PMID 22991504 DOI: 10.1155/2012/164140  0.68
2012 Sérandour AA, Avner S, Oger F, Bizot M, Percevault F, Lucchetti-Miganeh C, Palierne G, Gheeraert C, Barloy-Hubler F, Péron CL, Madigou T, Durand E, Froguel P, Staels B, Lefebvre P, et al. Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers. Nucleic Acids Research. 40: 8255-65. PMID 22730288 DOI: 10.1093/nar/gks595  0.68
2012 Maudoux A, Lefebvre P, Cabay JE, Demertzi A, Vanhaudenhuyse A, Laureys S, Soddu A. Connectivity graph analysis of the auditory resting state network in tinnitus. Brain Research. 1485: 10-21. PMID 22579727 DOI: 10.1016/j.brainres.2012.05.006  0.68
2012 Maudoux A, Lefebvre P, Cabay JE, Demertzi A, Vanhaudenhuyse A, Laureys S, Soddu A. Auditory resting-state network connectivity in tinnitus: a functional MRI study. Plos One. 7: e36222. PMID 22574141 DOI: 10.1371/journal.pone.0036222  0.68
2012 Lefebvre P, Staels B. Naturally improving insulin resistance with amorfrutins. Proceedings of the National Academy of Sciences of the United States of America. 109: 7136-7. PMID 22543162 DOI: 10.1073/pnas.1204455109  0.68
2012 Berthier A, Oger F, Gheeraert C, Boulahtouf A, Le Guével R, Balaguer P, Staels B, Salbert G, Lefebvre P. The novel antibacterial compound walrycin A induces human PXR transcriptional activity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 127: 225-35. PMID 22314385 DOI: 10.1093/toxsci/kfs073  0.68
2012 Lefebvre P, Chinetti G, Staels B. Nur77turing macrophages in atherosclerosis. Circulation Research. 110: 375-7. PMID 22302751 DOI: 10.1161/CIRCRESAHA.111.263178  0.68
2012 Briand O, Helleboid-Chapman A, Ploton M, Hennuyer N, Carpentier R, Pattou F, Vandewalle B, Moerman E, Gmyr V, Kerr-Conte J, Eeckhoute J, Staels B, Lefebvre P. The nuclear orphan receptor Nur77 is a lipotoxicity sensor regulating glucose-induced insulin secretion in pancreatic β-cells. Molecular Endocrinology (Baltimore, Md.). 26: 399-413. PMID 22301783 DOI: 10.1210/me.2011-1317  0.68
2012 Pawlak M, Lefebvre P, Staels B. General molecular biology and architecture of nuclear receptors. Current Topics in Medicinal Chemistry. 12: 486-504. PMID 22242852 DOI: 10.2174/156802612799436641  0.68
2012 Chinetti-Gbaguidi G, Bouhlel MA, Copin C, Duhem C, Derudas B, Neve B, Noel B, Eeckhoute J, Lefebvre P, Seckl JR, Staels B. Peroxisome proliferator-activated receptor-γ activation induces 11β-hydroxysteroid dehydrogenase type 1 activity in human alternative macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 677-85. PMID 22207732 DOI: 10.1161/ATVBAHA.111.241364  0.68
2012 Barriat S, van Wijck F, Staecker H, Lefebvre PP. Intratympanic steroid therapy using the Silverstein Microwickâ„¢ for refractory sudden sensorineural hearing loss increases speech intelligibility. Audiology & Neuro-Otology. 17: 105-11. PMID 21860229 DOI: 10.1159/000329367  0.68
2012 El-Shazly AE, Poirrier AL, Cabay J, Lefebvre PP. Anatomical variations of the lateral nasal wall: The secondary and accessory middle turbinates. Clinical Anatomy (New York, N.Y.). 25: 340-6. PMID 21671283 DOI: 10.1002/ca.21208  0.68
2011 El-Shazly AE, Henket M, Lefebvre PP, Louis R. 2B4 (CD244) is involved in eosinophil adhesion and chemotaxis, and its surface expression is increased in allergic rhinitis after challenge. International Journal of Immunopathology and Pharmacology. 24: 949-60. PMID 22230401  0.68
2011 El-Shazly AE, Moonen V, Mawet M, Begon D, Henket M, Arafa M, Louis R, Delvenne P, Lefebvre PP. IFN-γ and TNF-α potentiate prostaglandin D2-induced human eosinophil chemotaxis through up-regulation of CRTH2 surface receptor. International Immunopharmacology. 11: 1864-70. PMID 21835268 DOI: 10.1016/j.intimp.2011.07.017  0.68
2011 El-Shazly AE, Lefebvre PP. Modulation of NK cell autocrine-induced eosinophil chemotaxis by interleukin-15 and vitamin D(3): a possible NK-eosinophil crosstalk via IL-8 in the pathophysiology of allergic rhinitis. Mediators of Inflammation. 2011: 373589. PMID 21765616 DOI: 10.1155/2011/373589  0.68
2011 Berrabah W, Aumercier P, Lefebvre P, Staels B. Control of nuclear receptor activities in metabolism by post-translational modifications. Febs Letters. 585: 1640-50. PMID 21486568 DOI: 10.1016/j.febslet.2011.03.066  0.68
2010 Tombu S, Daele J, Lefebvre P. Rhinomanometry and acoustic rhinometry in rhinoplasty. B-Ent. 6: 3-11. PMID 21305918  0.68
2010 El-Shazly A, Barriat S, Lefebvre P. Nasopharyngeal bursitis: from embryology to clinical presentation. International Journal of General Medicine. 3: 331-4. PMID 21116338 DOI: 10.2147/IJGM.S13257  0.68
2010 Poirrier AL, Pincemail J, Van Den Ackerveken P, Lefebvre PP, Malgrange B. Oxidative stress in the cochlea: an update. Current Medicinal Chemistry. 17: 3591-604. PMID 20738243 DOI: 10.2174/092986710792927895  0.68
2010 El-Shazly A, Arafa M, Roncarati P, Dortu E, Lefebvre PP, Delvenne P. Characterization of hepatitis C virus-induced nasal mucosa remodelling. Histopathology. 57: 488-92. PMID 20731729 DOI: 10.1111/j.1365-2559.2010.03629.x  0.68
2010 Lefebvre P, Benomar Y, Staels B. Retinoid X receptors: common heterodimerization partners with distinct functions. Trends in Endocrinology and Metabolism: Tem. 21: 676-83. PMID 20674387 DOI: 10.1016/j.tem.2010.06.009  0.68
2010 Breuskin I, Bodson M, Thelen N, Thiry M, Borgs L, Nguyen L, Stolt C, Wegner M, Lefebvre PP, Malgrange B. Glial but not neuronal development in the cochleo-vestibular ganglion requires Sox10. Journal of Neurochemistry. 114: 1827-39. PMID 20626560 DOI: 10.1111/j.1471-4159.2010.06897.x  0.68
2010 Lefebvre B, Benomar Y, Guédin A, Langlois A, Hennuyer N, Dumont J, Bouchaert E, Dacquet C, Pénicaud L, Casteilla L, Pattou F, Ktorza A, Staels B, Lefebvre P. Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARgamma in obese mice and humans. The Journal of Clinical Investigation. 120: 1454-68. PMID 20364085 DOI: 10.1172/JCI38606  0.68
2010 Poirrier AL, Van den Ackerveken P, Kim TS, Vandenbosch R, Nguyen L, Lefebvre PP, Malgrange B. Ototoxic drugs: difference in sensitivity between mice and guinea pigs. Toxicology Letters. 193: 41-9. PMID 20015469 DOI: 10.1016/j.toxlet.2009.12.003  0.68
2010 Barriat S, Poirrier A, Malgrange B, Lefebvre P. Hearing preservation in cochlear implantation and drug treatment. Advances in Oto-Rhino-Laryngology. 67: 6-13. PMID 19955717 DOI: 10.1159/000262592  0.68
2010 Finck CL, Harmegnies B, Remacle A, Lefebvre P. Implantation of esterified hyaluronic acid in microdissected Reinke's space after vocal fold microsurgery: short- and long-term results. Journal of Voice : Official Journal of the Voice Foundation. 24: 626-35. PMID 19853408 DOI: 10.1016/j.jvoice.2008.12.015  0.68
2010 Bodson M, Breuskin I, Lefebvre P, Malgrange B. Hair cell progenitors: identification and regulatory genes. Acta Oto-Laryngologica. 130: 312-7. PMID 19593682 DOI: 10.1080/00016480903121057  0.68
2010 Maudoux A, Poirrier AL, Lefebvre P, Demanez L. Functional imaging and hearing | Imagerie fonctionnelle et audition Cahiers De L'Audition. 23: 24-28.  0.68
2009 Martin C, Deveze A, Richard C, Lefebvre PP, Decat M, Ibañez LG, Truy E, Mom T, Lavieille JP, Magnan J, Dubreuil C, Tringali S. European results with totally implantable carina placed on the round window: 2-year follow-up. Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 30: 1196-203. PMID 19890224 DOI: 10.1097/MAO.0b013e3181c34898  0.68
2009 Breuskin I, Bodson M, Thelen N, Thiry M, Borgs L, Nguyen L, Lefebvre PP, Malgrange B. Sox10 promotes the survival of cochlear progenitors during the establishment of the organ of Corti. Developmental Biology. 335: 327-39. PMID 19748502 DOI: 10.1016/j.ydbio.2009.09.007  0.68
2009 Sacheli R, Nguyen L, Borgs L, Vandenbosch R, Bodson M, Lefebvre P, Malgrange B. Expression patterns of miR-96, miR-182 and miR-183 in the development inner ear. Gene Expression Patterns : Gep. 9: 364-70. PMID 19602392 DOI: 10.1016/j.gep.2009.01.003  0.68
2009 Poirrier AL, Gillard-Tromme N, Lefebvre PP, El-Shazly A. Pertussis in adulthood: report of two cases and review of the literature. The Laryngoscope. 119: 1720-2. PMID 19572274 DOI: 10.1002/lary.20566  0.68
2009 Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. Role of bile acids and bile acid receptors in metabolic regulation. Physiological Reviews. 89: 147-91. PMID 19126757 DOI: 10.1152/physrev.00010.2008  0.68
2009 Carmona MC, Lefebvre P, Lefebvre B, Galinier A, Benani A, Jeanson Y, Louche K, Flajollet S, Ktorza A, Dacquet C, Pénicaud L, Casteilla L. Coadministration of coenzyme Q prevents rosiglitazone-induced adipogenesis in ob/ob mice. International Journal of Obesity (2005). 33: 204-11. PMID 19125161 DOI: 10.1038/ijo.2008.265  0.68
2009 Lefebvre PP, Martin C, Dubreuil C, Decat M, Yazbeck A, Kasic J, Tringali S. A pilot study of the safety and performance of the Otologics fully implantable hearing device: transducing sounds via the round window membrane to the inner ear. Audiology & Neuro-Otology. 14: 172-80. PMID 19005251 DOI: 10.1159/000171479  0.68
2009 El-Shazly AE, Henket M, Lefebvre PP, Louis R. Defective eosinophil chemotaxis to eotaxin in a patient with chronic lower baseline CD4+ T-lymphocytes and elevated CD8+ T cells International Journal of General Medicine. 2: 187-194.  0.68
2008 Frenz CM, Lefebvre PP. Molecular modelling insights into DFNA15 mediated enhancement of POU4F3 stability. International Journal of Computational Biology and Drug Design. 1: 295-301. PMID 20054994 DOI: 10.1504/IJCBDD.2008.021429  0.68
2008 Rigamonti E, Fontaine C, Lefebvre B, Duhem C, Lefebvre P, Marx N, Staels B, Chinetti-Gbaguidi G. Induction of CXCR2 receptor by peroxisome proliferator-activated receptor gamma in human macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 932-9. PMID 18292390 DOI: 10.1161/ATVBAHA.107.161679  0.68
2008 Carpentier R, Sacchetti P, Ségard P, Staels B, Lefebvre P. The glucocorticoid receptor is a co-regulator of the orphan nuclear receptor Nurr1. Journal of Neurochemistry. 104: 777-89. PMID 17986226 DOI: 10.1111/j.1471-4159.2007.05055.x  0.68
2008 Breuskin I, Bodson M, Thelen N, Thiry M, Nguyen L, Belachew S, Lefebvre PP, Malgrange B. Strategies to regenerate hair cells: identification of progenitors and critical genes. Hearing Research. 236: 1-10. PMID 17920797 DOI: 10.1016/j.heares.2007.08.007  0.68
2007 Maudoux A, Bonnet S, Lhonneux-Ledoux F, Lefebvre P. Ericksonian hypnosis in tinnitus therapy. B-Ent. 3: 75-7. PMID 18225612  0.68
2007 Van de Heyning P, Lefebvre P, De Ridder D. Tinnitus: from cochlear to cortical. B-Ent. 3: 1-2. PMID 18225602  0.68
2007 Lallemend F, Vandenbosch R, Hadjab S, Bodson M, Breuskin I, Moonen G, Lefebvre PP, Malgrange B. New insights into peripherin expression in cochlear neurons. Neuroscience. 150: 212-22. PMID 17964735 DOI: 10.1016/j.neuroscience.2007.08.032  0.68
2007 Van Wijck F, Staecker H, Lefebvre PP. Topical steroid therapy using the Silverstein Microwick in sudden sensorineural hearing loss after failure of conventional treatment. Acta Oto-Laryngologica. 127: 1012-7. PMID 17851934 DOI: 10.1080/00016480601126952  0.68
2007 Carmona MC, Louche K, Lefebvre B, Pilon A, Hennuyer N, Audinot-Bouchez V, Fievet C, Torpier G, Formstecher P, Renard P, Lefebvre P, Dacquet C, Staels B, Casteilla L, Pénicaud L, et al. S 26948: a new specific peroxisome proliferator activated receptor gamma modulator with potent antidiabetes and antiatherogenic effects. Diabetes. 56: 2797-808. PMID 17704298 DOI: 10.2337/db06-1734  0.68
2007 Flajollet S, Lefebvre B, Cudejko C, Staels B, Lefebvre P. The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor. Molecular and Cellular Endocrinology. 270: 23-32. PMID 17363140 DOI: 10.1016/j.mce.2007.02.004  0.68
2007 Staecker H, Liu W, Malgrange B, Lefebvre PP, Van De Water TR. Vector-mediated delivery of bcl-2 prevents degeneration of auditory hair cells and neurons after injury. Orl; Journal For Oto-Rhino-Laryngology and Its Related Specialties. 69: 43-50. PMID 17085952 DOI: 10.1159/000096716  0.68
2007 Van De Heyning PH, De Valck CFJ, Boudewyns A, Cammaert T, Casteleyn S, Deggouj N, Gordts F, Forton G, Lefebvre P, Robillard T. Ménière's disease B-Ent. 3: 11-20.  0.68
2006 Sacchetti P, Carpentier R, Ségard P, Olivé-Cren C, Lefebvre P. Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1. Nucleic Acids Research. 34: 5515-27. PMID 17020917 DOI: 10.1093/nar/gkl712  0.68
2006 Van Wijk F, Staecker H, Keithley E, Lefebvre PP. Local perfusion of the tumor necrosis factor alpha blocker infliximab to the inner ear improves autoimmune neurosensory hearing loss. Audiology & Neuro-Otology. 11: 357-65. PMID 16988499 DOI: 10.1159/000095897  0.68
2006 Flajollet S, Lefebvre B, Rachez C, Lefebvre P. Distinct roles of the steroid receptor coactivator 1 and of MED1 in retinoid-induced transcription and cellular differentiation. The Journal of Biological Chemistry. 281: 20338-48. PMID 16723356 DOI: 10.1074/jbc.M603023200  0.68
2006 Lefebvre B, Brand C, Flajollet S, Lefebvre P. Down-regulation of the tumor suppressor gene retinoic acid receptor beta2 through the phosphoinositide 3-kinase/Akt signaling pathway. Molecular Endocrinology (Baltimore, Md.). 20: 2109-21. PMID 16613989 DOI: 10.1210/me.2005-0321  0.68
2006 Lefebvre P, Chinetti G, Fruchart JC, Staels B. Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. The Journal of Clinical Investigation. 116: 571-80. PMID 16511589 DOI: 10.1172/JCI27989  0.68
2006 Dedieu S, Lefebvre P. Retinoids interfere with the AP1 signalling pathway in human breast cancer cells. Cellular Signalling. 18: 889-98. PMID 16176868 DOI: 10.1016/j.cellsig.2005.08.001  0.68
2005 Finck C, Lefebvre P. Implantation of esterified hyaluronic acid in microdissected Reinke's space after vocal fold microsurgery: first clinical experiences. The Laryngoscope. 115: 1841-7. PMID 16222207 DOI: 10.1097/01.mlg.0000173158.22274.8d  0.68
2005 Lallemend F, Hadjab S, Hans G, Moonen G, Lefebvre PP, Malgrange B. Activation of protein kinase CbetaI constitutes a new neurotrophic pathway for deafferented spiral ganglion neurons. Journal of Cell Science. 118: 4511-25. PMID 16179609 DOI: 10.1242/jcs.02572  0.68
2005 Martin PJ, Lardeux V, Lefebvre P. The proliferating cell nuclear antigen regulates retinoic acid receptor transcriptional activity through direct protein-protein interaction. Nucleic Acids Research. 33: 4311-21. PMID 16055921 DOI: 10.1093/nar/gki745  0.68
2005 Lallemend F, Lefebvre PP, Hans G, Moonen G, Malgrange B. Molecular pathways involved in apoptotic cell death in the injured cochlea: cues to novel therapeutic strategies. Current Pharmaceutical Design. 11: 2257-75. PMID 16026294 DOI: 10.2174/1381612054367346  0.68
2005 Geffroy N, Guédin A, Dacquet C, Lefebvre P. Cell cycle regulation of breast cancer cells through estrogen-induced activities of ERK and Akt protein kinases. Molecular and Cellular Endocrinology. 237: 11-23. PMID 15925090 DOI: 10.1016/j.mce.2005.04.003  0.68
2005 Rousseaux C, Lefebvre B, Dubuquoy L, Lefebvre P, Romano O, Auwerx J, Metzger D, Wahli W, Desvergne B, Naccari GC, Chavatte P, Farce A, Bulois P, Cortot A, Colombel JF, et al. Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma. The Journal of Experimental Medicine. 201: 1205-15. PMID 15824083 DOI: 10.1084/jem.20041948  0.68
2005 Lefebvre P, Martin PJ, Flajollet S, Dedieu S, Billaut X, Lefebvre B. Transcriptional activities of retinoic acid receptors. Vitamins and Hormones. 70: 199-264. PMID 15727806 DOI: 10.1016/S0083-6729(05)70007-8  0.68
2005 Duez H, Lefebvre B, Poulain P, Torra IP, Percevault F, Luc G, Peters JM, Gonzalez FJ, Gineste R, Helleboid S, Dzavik V, Fruchart JC, Fiévet C, Lefebvre P, Staels B. Regulation of human apoA-I by gemfibrozil and fenofibrate through selective peroxisome proliferator-activated receptor alpha modulation. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 585-91. PMID 15618549 DOI: 10.1161/01.ATV.0000154140.73570.00  0.68
2004 Van De Water TR, Lallemend F, Eshraghi AA, Ahsan S, He J, Guzman J, Polak M, Malgrange B, Lefebvre PP, Staecker H, Balkany TJ. Caspases, the enemy within, and their role in oxidative stress-induced apoptosis of inner ear sensory cells. Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 25: 627-32. PMID 15241246 DOI: 10.1097/00129492-200407000-00035  0.68
2004 Kim TS, Kojima K, Nishida AT, Tashiro K, Lee JE, Fujino K, Nakagawa T, Naito Y, Omori K, Lefebvre P, Ito J. Expression of calretinin by fetal otocyst cells after transplantation into damaged rat utricle explants. Acta Oto-Laryngologica. Supplementum. 34-8. PMID 15078075 DOI: 10.1080/03655230310016771  0.68
2004 Lefebvre P, Velasco PT, Dear A, Lounes KC, Lord ST, Brennan SO, Green D, Lorand L. Severe hypodysfibrinogenemia in compound heterozygotes of the fibrinogen AalphaIVS4 + 1G>T mutation and an AalphaGln328 truncation (fibrinogen Keokuk). Blood. 103: 2571-6. PMID 14615374 DOI: 10.1182/blood-2003-07-2316  0.68
2004 Kim TS, Nakagawa T, Lee JE, Fujino K, Iguchi F, Endo T, Naito Y, Omori K, Lefebvre PP, Ito J. Induction of cell proliferation and-Catenin expression in Rat utricles in vitro Acta Oto-Laryngologica. 124: 22-25. DOI: 10.1080/03655230310016672  0.68
2003 Eeckhoute J, Oxombre B, Formstecher P, Lefebvre P, Laine B. Critical role of charged residues in helix 7 of the ligand binding domain in Hepatocyte Nuclear Factor 4alpha dimerisation and transcriptional activity. Nucleic Acids Research. 31: 6640-50. PMID 14602925  0.36
2003 Martin PJ, Delmotte MH, Formstecher P, Lefebvre P. PLZF is a negative regulator of retinoic acid receptor transcriptional activity. Nuclear Receptor. 1: 6. PMID 14521715 DOI: 10.1186/1478-1336-1-6  0.36
2003 Lallemend F, Lefebvre PP, Hans G, Rigo JM, Van de Water TR, Moonen G, Malgrange B. Substance P protects spiral ganglion neurons from apoptosis via PKC-Ca2+-MAPK/ERK pathways. Journal of Neurochemistry. 87: 508-21. PMID 14511128 DOI: 10.1046/j.1471-4159.2003.02014.x  0.68
2003 Malgrange B, Knockaert M, Belachew S, Nguyen L, Moonen G, Meijer L, Lefebvre PP. The inhibition of cyclin-dependent kinases induces differentiation of supernumerary hair cells and Deiters' cells in the developing organ of Corti. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 2136-8. PMID 12958157 DOI: 10.1096/fj.03-0035fje  0.68
2003 Jouault T, Ibata-Ombetta S, Takeuchi O, Trinel PA, Sacchetti P, Lefebvre P, Akira S, Poulain D. Candida albicans phospholipomannan is sensed through toll-like receptors. The Journal of Infectious Diseases. 188: 165-72. PMID 12825186 DOI: 10.1086/375784  0.68
2003 Scarpidis U, Madnani D, Shoemaker C, Fletcher CH, Kojima K, Eshraghi AA, Staecker H, Lefebvre P, Malgrange B, Balkany TJ, Van De Water TR. Arrest of apoptosis in auditory neurons: implications for sensorineural preservation in cochlear implantation. Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 24: 409-17. PMID 12806293 DOI: 10.1097/00129492-200305000-00011  0.68
2002 Lefebvre PP, Staecker H, Van De Water T, Moonen G, Malgrange B. Microperfusion of the inner ear. Acta Oto-Rhino-Laryngologica Belgica. 56: 365-8. PMID 12528254  0.68
2002 Malgrange B, Rigo JM, Coucke P, Thiry M, Hans G, Nguyen L, van de Water TR, Moonen G, Lefebvre PP. Identification of factors that maintain mammalian outer hair cells in adult organ of Corti explants. Hearing Research. 170: 48-58. PMID 12208540 DOI: 10.1016/S0378-5955(02)00451-3  0.68
2002 Sacchetti P, Dwornik H, Formstecher P, Rachez C, Lefebvre P. Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors. The Journal of Biological Chemistry. 277: 35088-96. PMID 12122012 DOI: 10.1074/jbc.M205816200  0.68
2002 Lefebvre PP, Malgrange B, Lallemend F, Staecker H, Moonen G, Van De Water TR. Mechanisms of cell death in the injured auditory system: otoprotective strategies. Audiology & Neuro-Otology. 7: 165-70. PMID 12053139 DOI: 10.1159/000058304  0.68
2002 Benkoussa M, Brand C, Delmotte MH, Formstecher P, Lefebvre P. Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter. Molecular and Cellular Biology. 22: 4522-34. PMID 12052862  0.36
2002 Brand C, Ségard P, Plouvier P, Formstecher P, Danzé PM, Lefebvre P. Selective alteration of gene expression in response to natural and synthetic retinoids. Bmc Pharmacology. 2: 13. PMID 12019025  0.68
2002 Lefebvre B, Ozato K, Lefebvre P. Phosphorylation of histone H3 is functionally linked to retinoic acid receptor beta promoter activation. Embo Reports. 3: 335-40. PMID 11897660 DOI: 10.1093/embo-reports/kvf066  0.68
2002 Malgrange B, Belachew S, Thiry M, Nguyen L, Rogister B, Alvarez ML, Rigo JM, Van De Water TR, Moonen G, Lefebvre PP. Proliferative generation of mammalian auditory hair cells in culture. Mechanisms of Development. 112: 79-88. PMID 11850180 DOI: 10.1016/S0925-4773(01)00642-6  0.68
2002 Lefebvre B, Brand C, Lefebvre P, Ozato K. Chromosomal integration of retinoic acid response elements prevents cooperative transcriptional activation by retinoic acid receptor and retinoid X receptor. Molecular and Cellular Biology. 22: 1446-59. PMID 11839811 DOI: 10.1128/MCB.22.5.1446-1459.2002  0.68
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