Ciaran M. Regan - Publications

Conway Institute, University College Dublin, Donnybrook, County Dublin, Ireland 
NCAM, polysialic acid, memory

47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Rendeiro C, Foley A, Lau VC, Ring R, Rodriguez-Mateos A, Vauzour D, Williams CM, Regan C, Spencer JP. A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats. Neuropharmacology. 79: 335-44. PMID 24333331 DOI: 10.1016/j.neuropharm.2013.12.003  0.329
2012 Scully D, Fedriani R, Desouza IE, Murphy KJ, Regan CM. Regional dissociation of paradigm-specific synapse remodeling during memory consolidation in the adult rat dentate gyrus. Neuroscience. 209: 74-83. PMID 22285310 DOI: 10.1016/j.neuroscience.2012.01.020  0.344
2011 Monopoli MP, Raghnaill MN, Loscher JS, O'Sullivan NC, Pangalos MN, Ring RH, von Schack D, Dunn MJ, Regan CM, Pennington S, Murphy KJ. Temporal proteomic profile of memory consolidation in the rat hippocampal dentate gyrus. Proteomics. 11: 4189-201. PMID 22002935 DOI: 10.1002/pmic.201100072  0.335
2011 Freir DB, Fedriani R, Scully D, Smith IM, Selkoe DJ, Walsh DM, Regan CM. Aβ oligomers inhibit synapse remodelling necessary for memory consolidation. Neurobiology of Aging. 32: 2211-8. PMID 20097446 DOI: 10.1016/J.Neurobiolaging.2010.01.001  0.437
2010 Cassidy AW, Mulvany SK, Pangalos MN, Murphy KJ, Regan CM. Reduced reelin protein synthesis in ventral hippocampus of isolation reared Wistar rats accompanies impaired avoidance conditioning. Behavioural Brain Research. 213: 130-4. PMID 20438765 DOI: 10.1016/J.Bbr.2010.04.040  0.393
2010 Murphy KJ, Ter Horst JP, Cassidy AW, DeSouza IE, Morgunova M, Li C, Connole LM, O'Sullivan NC, Loscher JS, Brady AT, Rombach N, Connellan J, McGettigan PA, Scully D, Fedriani R, ... ... Regan CM, et al. Temporal dysregulation of cortical gene expression in the isolation reared Wistar rat. Journal of Neurochemistry. 113: 601-14. PMID 20096092 DOI: 10.1111/J.1471-4159.2010.06617.X  0.631
2010 Cassidy AW, Mulvany SK, Pangalos MN, Murphy KJ, Regan CM. Developmental emergence of reelin deficits in the prefrontal cortex of Wistar rats reared in social isolation. Neuroscience. 166: 377-85. PMID 20035841 DOI: 10.1016/J.Neuroscience.2009.12.045  0.375
2010 McKee AG, Loscher JS, O'Sullivan NC, Chadderton N, Palfi A, Batti L, Sheridan GK, O'Shea S, Moran M, McCabe O, Fernández AB, Pangalos MN, O'Connor JJ, Regan CM, O'Connor WT, et al. AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity. Journal of Neurochemistry. 112: 991-1004. PMID 20002519 DOI: 10.1111/J.1471-4159.2009.06516.X  0.434
2009 Foley AG, Prendergast A, Barry C, Scully D, Upton N, Medhurst AD, Regan CM. H3 receptor antagonism enhances NCAM PSA-mediated plasticity and improves memory consolidation in odor discrimination and delayed match-to-position paradigms. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 2585-600. PMID 19657331 DOI: 10.1038/Npp.2009.89  0.457
2009 Conboy L, Foley AG, O'Boyle NM, Lawlor M, Gallagher HC, Murphy KJ, Regan CM. Curcumin-induced degradation of PKC delta is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats. Biochemical Pharmacology. 77: 1254-65. PMID 19161989 DOI: 10.1016/j.bcp.2008.12.011  0.309
2008 Seymour CM, Foley AG, Murphy KJ, Regan CM. Intraventricular infusions of anti-NCAM PSA impair the process of consolidation of both avoidance conditioning and spatial learning paradigms in Wistar rats. Neuroscience. 157: 813-20. PMID 18948173 DOI: 10.1016/J.Neuroscience.2008.09.041  0.457
2008 Ter Horst JP, Loscher JS, Pickering M, Regan CM, Murphy KJ. Learning-associated regulation of polysialylated neural cell adhesion molecule expression in the rat prefrontal cortex is region-, cell type- and paradigm-specific. The European Journal of Neuroscience. 28: 419-27. PMID 18702715 DOI: 10.1111/J.1460-9568.2008.06326.X  0.433
2008 Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nature Medicine. 14: 837-42. PMID 18568035 DOI: 10.1038/Nm1782  0.319
2007 Conboy L, Seymour CM, Monopoli MP, O'Sullivan NC, Murphy KJ, Regan CM. Notch signalling becomes transiently attenuated during long-term memory consolidation in adult Wistar rats. Neurobiology of Learning and Memory. 88: 342-51. PMID 17543552 DOI: 10.1016/J.Nlm.2007.04.006  0.397
2007 Medhurst AD, Atkins AR, Beresford IJ, Brackenborough K, Briggs MA, Calver AR, Cilia J, Cluderay JE, Crook B, Davis JB, Davis RK, Davis RP, Dawson LA, Foley AG, Gartlon J, ... ... Regan CM, et al. GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. The Journal of Pharmacology and Experimental Therapeutics. 321: 1032-45. PMID 17327487 DOI: 10.1124/Jpet.107.120311  0.312
2007 O'Sullivan NC, McGettigan PA, Sheridan GK, Pickering M, Conboy L, O'Connor JJ, Moynagh PN, Higgins DG, Regan CM, Murphy KJ. Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning. Journal of Neurochemistry. 101: 1085-98. PMID 17298388 DOI: 10.1111/J.1471-4159.2006.04418.X  0.652
2006 Hirst WD, Stean TO, Rogers DC, Sunter D, Pugh P, Moss SF, Bromidge SM, Riley G, Smith DR, Bartlett S, Heidbreder CA, Atkins AR, Lacroix LP, Dawson LA, Foley AG, ... Regan CM, et al. SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. European Journal of Pharmacology. 553: 109-19. PMID 17069795 DOI: 10.1016/J.Ejphar.2006.09.049  0.317
2006 Murphy KJ, Foley AG, O'connell AW, Regan CM. Chronic exposure of rats to cognition enhancing drugs produces a neuroplastic response identical to that obtained by complex environment rearing. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 90-100. PMID 15988469 DOI: 10.1038/Sj.Npp.1300810  0.357
2005 Conboy L, Murphy KJ, Regan CM. Amyloid precursor protein expression in the rat hippocampal dentate gyrus modulates during memory consolidation. Journal of Neurochemistry. 95: 1677-88. PMID 16236032 DOI: 10.1111/J.1471-4159.2005.03484.X  0.431
2005 Foley AG, Murphy KJ, Regan CM. Complex-environment rearing prevents prenatal hypoxia-induced deficits in hippocampal cellular mechanisms necessary for memory consolidation in the adult Wistar rat. Journal of Neuroscience Research. 82: 245-54. PMID 16175578 DOI: 10.1002/jnr.20641  0.305
2004 Sandi C, Cordero MI, Merino JJ, Kruyt ND, Regan CM, Murphy KJ. Neurobiological and endocrine correlates of individual differences in spatial learning ability. Learning & Memory (Cold Spring Harbor, N.Y.). 11: 244-52. PMID 15169853 DOI: 10.1101/Lm.73904  0.42
2004 Foley AG, Gallagher HC, Murphy KJ, Regan CM. Pentyl-4-yn-valproic acid reverses age-associated memory impairment in the Wistar rat. Neurobiology of Aging. 25: 539-46. PMID 15013575 DOI: 10.1016/J.Neurobiolaging.2003.07.006  0.367
2004 O'Loinsigh ED, Gherardini LM, Gallagher HC, Foley AG, Murphy KJ, Regan CM. Differential enantioselective effects of pentyl-4-yn-valproate on spatial learning in the rat, and neurite outgrowth and cyclin D3 expression in vitro. Journal of Neurochemistry. 88: 370-9. PMID 14690525 DOI: 10.1111/J.1471-4159.2004.02158.X  0.349
2003 Foley AG, Rønn LC, Murphy KJ, Regan CM. Distribution of polysialylated neural cell adhesion molecule in rat septal nuclei and septohippocampal pathway: transient increase of polysialylated interneurons in the subtriangular septal zone during memory consolidation. Journal of Neuroscience Research. 74: 807-17. PMID 14648585 DOI: 10.1002/jnr.10820  0.356
2003 Foley AG, Hedigan K, Roullet P, Moricard Y, Murphy KJ, Sara SJ, Regan CM. Consolidation of memory for odour-reward association requires transient polysialylation of the neural cell adhesion molecule in the rat hippocampal dentate gyrus. Journal of Neuroscience Research. 74: 570-6. PMID 14598301 DOI: 10.1002/Jnr.10758  0.441
2003 Sandi C, Merino JJ, Cordero MI, Kruyt ND, Murphy KJ, Regan CM. Modulation of hippocampal NCAM polysialylation and spatial memory consolidation by fear conditioning. Biological Psychiatry. 54: 599-607. PMID 13129654 DOI: 10.1016/S0006-3223(03)00182-3  0.434
2001 Murphy KJ, Fox GB, Foley AG, Gallagher HC, O'Connell A, Griffin AM, Nau H, Regan CM. Pentyl-4-yn-valproic acid enhances both spatial and avoidance learning, and attenuates age-related NCAM-mediated neuroplastic decline within the rat medial temporal lobe. Journal of Neurochemistry. 78: 704-14. PMID 11520891 DOI: 10.1046/J.1471-4159.2001.00411.X  0.448
2001 Gallagher HC, Murphy KJ, Foley AG, Regan CM. Protein kinase C delta regulates neural cell adhesion molecule polysialylation state in the rat brain. Journal of Neurochemistry. 77: 425-34. PMID 11299305 DOI: 10.1046/J.1471-4159.2001.00235.X  0.433
2000 O'Connell C, Gallagher HC, O'Malley A, Bourke M, Regan CM. CREB phosphorylation coincides with transient synapse formation in the rat hippocampal dentate gyrus following avoidance learning. Neural Plasticity. 7: 279-89. PMID 11486487 DOI: 10.1155/Np.2000.279  0.468
2000 Fox GB, Fichera G, Barry T, O'Connell AW, Gallagher HC, Murphy KJ, Regan CM. Consolidation of passive avoidance learning is associated with transient increases of polysialylated neurons in layer II of the rat medial temporal cortex. Journal of Neurobiology. 45: 135-41. PMID 11074459 DOI: 10.1002/1097-4695(20001115)45:3<135::AID-NEU1>3.0.CO;2  0.354
2000 Gallagher HC, Odumeru OA, Regan CM. Regulation of neural cell adhesion molecule polysialylation state by cell-cell contact and protein kinase C delta. Journal of Neuroscience Research. 61: 636-45. PMID 10972960 DOI: 10.1002/1097-4547(20000915)61:6<636::Aid-Jnr7>3.0.Co;2-F  0.383
2000 O'Malley A, O'Connell C, Murphy KJ, Regan CM. Transient spine density increases in the mid-molecular layer of hippocampal dentate gyrus accompany consolidation of a spatial learning task in the rodent. Neuroscience. 99: 229-32. PMID 10938428 DOI: 10.1016/S0306-4522(00)00182-2  0.414
2000 Foley AG, Hartz BP, Gallagher HC, Rønn LC, Berezin V, Bock E, Regan CM. A synthetic peptide ligand of neural cell adhesion molecule (NCAM) IgI domain prevents NCAM internalization and disrupts passive avoidance learning. Journal of Neurochemistry. 74: 2607-13. PMID 10820224 DOI: 10.1046/J.1471-4159.2000.0742607.X  0.431
1999 Murphy KJ, Regan CM. Low-level lead exposure in the early postnatal period results in persisting neuroplastic deficits associated with memory consolidation. Journal of Neurochemistry. 72: 2099-104. PMID 10217290 DOI: 10.1046/j.1471-4159.1999.0722099.x  0.318
1998 Gratacós E, Ghelardini C, Gherardini LM, Galeotti N, Murphy KJ, Bartolini A, Regan CM. Kv1.1 channel antisense attenuates learning and modulation of dentate polysialylated NCAM. Neuroreport. 9: 2727-31. PMID 9760110 DOI: 10.1097/00001756-199808240-00008  0.321
1998 O'Malley A, O'Connell C, Regan CM. Ultrastructural analysis reveals avoidance conditioning to induce a transient increase in hippocampal dentate spine density in the 6 hour post-training period of consolidation. Neuroscience. 87: 607-13. PMID 9758227 DOI: 10.1016/S0306-4522(98)00178-X  0.445
1998 Murphy KJ, Regan CM. Contributions of cell adhesion molecules to altered synaptic weightings during memory consolidation. Neurobiology of Learning and Memory. 70: 73-81. PMID 9753588 DOI: 10.1006/nlme.1998.3839  0.363
1997 O'Connell AW, Fox GB, Barry T, Murphy KJ, Fichera G, Foley AG, Kelly J, Regan CM. Spatial learning activates neural cell adhesion molecule polysialylation in a corticohippocampal pathway within the medial temporal lobe. Journal of Neurochemistry. 68: 2538-46. PMID 9166750 DOI: 10.1046/J.1471-4159.1997.68062538.X  0.328
1997 Odumeru O, Murphy KJ, O'Connell AW, Regan CM, Shiotani T. Influence of nefiracetam on NGF-induced neuritogenesis and neural cell adhesion molecule polysialic acid expression: in vivo and in vitro comparisons. Behavioural Brain Research. 83: 173-8. PMID 9062679 DOI: 10.1016/S0166-4328(97)86064-0  0.327
1997 O'Connell C, O'Malley A, Regan CM. Transient, learning-induced ultrastructural change in spatially-clustered dentate granule cells of the adult rat hippocampus. Neuroscience. 76: 55-62. PMID 8971758 DOI: 10.1016/S0306-4522(96)00387-9  0.444
1996 Murphy KJ, O'Connell AW, Regan CM. Repetitive and transient increases in hippocampal neural cell adhesion molecule polysialylation state following multitrial spatial training. Journal of Neurochemistry. 67: 1268-74. PMID 8752135  0.316
1995 Fox GB, O'Connell AW, Murphy KJ, Regan CM. Memory consolidation induces a transient and time-dependent increase in the frequency of neural cell adhesion molecule polysialylated cells in the adult rat hippocampus. Journal of Neurochemistry. 65: 2796-9. PMID 7595580 DOI: 10.1046/j.1471-4159.1995.65062796.x  0.369
1992 Doyle E, Nolan PM, Bell R, Regan CM. Hippocampal NCAM180 transiently increases sialylation during the acquisition and consolidation of a passive avoidance response in the adult rat. Journal of Neuroscience Research. 31: 513-23. PMID 1640502 DOI: 10.1002/jnr.490310315  0.341
1989 Regan CM. Lead-impaired neurodevelopment. Mechanisms and threshold values in the rodent. Neurotoxicology and Teratology. 11: 533-7. PMID 2696874 DOI: 10.1016/0892-0362(89)90033-0  0.329
1987 Regan CM, Meier E, Balazs R. The effect of a neuron-specific antiserum, BPM, on the in vitro development of cerebellar granule cells. Cellular and Molecular Neurobiology. 7: 61-71. PMID 3594518 DOI: 10.1007/BF00734990  0.485
1984 Meier E, Regan CM, Balazs R. Changes in the expression of a neuronal surface protein during development of cerebellar neurones in vivo and in culture. Journal of Neurochemistry. 43: 1328-35. PMID 6387049  0.495
1982 Patel AJ, Regan CM, Annunziata P, Meier E, Balázs R. Biochemical characterization and interaction of neuronal and glial cells in culture. Biochemical Society Transactions. 10: 419-21. PMID 6128278  0.459
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