Steven M. Paul - Publications

Affiliations: 
Eli Lilly and Co., Basingstoke, England, United Kingdom 
Area:
Alcohol, GABA, neurosteroids, dementia
Website:
http://www.lilly.com/about/executive/paul_steven/

118 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Zhao L, Gottesdiener AJ, Parmar M, Li M, Kaminsky SM, Chiuchiolo MJ, Sondhi D, Sullivan PM, Holtzman DM, Crystal RG, Paul SM. Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models. Neurobiology of Aging. 44: 159-172. PMID 27318144 DOI: 10.1016/j.neurobiolaging.2016.04.020  0.96
2015 Kim KH, Liu J, Sells Galvin RJ, Dage JL, Egeland JA, Smith RC, Merchant KM, Paul SM. Transcriptomic Analysis of Induced Pluripotent Stem Cells Derived from Patients with Bipolar Disorder from an Old Order Amish Pedigree. Plos One. 10: e0142693. PMID 26554713 DOI: 10.1371/journal.pone.0142693  0.96
2015 Chen CH, Peng Q, Schork AJ, Lo MT, Fan CC, Wang Y, Desikan RS, Bettella F, Hagler DJ, Westlye LT, Kremen WS, Jernigan TL, Hellard SL, et al. Large-scale genomics unveil polygenic architecture of human cortical surface area. Nature Communications. 6: 7549. PMID 26189703 DOI: 10.1038/ncomms8549  0.96
2015 Luo W, Liu W, Hu X, Hanna M, Caravaca A, Paul SM. Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody. Scientific Reports. 5: 11161. PMID 26057852 DOI: 10.1038/srep11161  0.96
2015 Ayton S, Faux NG, Bush AI. Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE. Nature Communications. 6: 6760. PMID 25988319 DOI: 10.1038/ncomms7760  0.96
2015 Kember RL, Georgi B, Bailey-Wilson JE, Stambolian D, Paul SM, Bu?an M. Copy number variants encompassing Mendelian disease genes in a large multigenerational family segregating bipolar disorder. Bmc Genetics. 16: 27. PMID 25887117 DOI: 10.1186/s12863-015-0184-1  0.96
2015 Emnett CM, Eisenman LN, Mohan J, Taylor AA, Doherty JJ, Paul SM, Zorumski CF, Mennerick S. Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel. British Journal of Pharmacology. 172: 1333-47. PMID 25377730 DOI: 10.1111/bph.13007  0.96
2014 Choi DW, Armitage R, Brady LS, Coetzee T, Fisher W, Hyman S, Pande A, Paul S, Potter W, Roin B, Sherer T. Medicines for the mind: policy-based "pull" incentives for creating breakthrough CNS drugs. Neuron. 84: 554-63. PMID 25442934 DOI: 10.1016/j.neuron.2014.10.027  0.96
2014 Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, ... ... Paul S, et al. 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: S430-52. PMID 25341459 DOI: 10.1016/j.jalz.2014.08.103  0.96
2014 Paul SM, Reddy K. Young blood rejuvenates old brains. Nature Medicine. 20: 582-3. PMID 24901563 DOI: 10.1038/nm.3597  0.96
2014 Linsenbardt AJ, Taylor A, Emnett CM, Doherty JJ, Krishnan K, Covey DF, Paul SM, Zorumski CF, Mennerick S. Different oxysterols have opposing actions at N-methyl-D-aspartate receptors. Neuropharmacology. 85: 232-42. PMID 24878244 DOI: 10.1016/j.neuropharm.2014.05.027  0.96
2014 Georgi B, Craig D, Kember RL, Liu W, Lindquist I, Nasser S, Brown C, Egeland JA, Paul SM, Bućan M. Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate. Plos Genetics. 10: e1004229. PMID 24625924 DOI: 10.1371/journal.pgen.1004229  0.96
2014 Rohan ML, Yamamoto RT, Ravichandran CT, Cayetano KR, Morales OG, Olson DP, Vitaliano G, Paul SM, Cohen BM. Rapid mood-elevating effects of low field magnetic stimulation in depression. Biological Psychiatry. 76: 186-93. PMID 24331545 DOI: 10.1016/j.biopsych.2013.10.024  0.96
2013 Paul SM, Doherty JJ, Robichaud AJ, Belfort GM, Chow BY, Hammond RS, Crawford DC, Linsenbardt AJ, Shu HJ, Izumi Y, Mennerick SJ, Zorumski CF. The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 17290-300. PMID 24174662 DOI: 10.1523/JNEUROSCI.2619-13.2013  0.96
2013 Paul SM, Lewis-Hall F. Drugs in search of diseases. Science Translational Medicine. 5: 186fs18. PMID 23698376 DOI: 10.1126/scitranslmed.3004452  0.96
2013 Zorumski CF, Paul SM, Izumi Y, Covey DF, Mennerick S. Neurosteroids, stress and depression: potential therapeutic opportunities. Neuroscience and Biobehavioral Reviews. 37: 109-22. PMID 23085210 DOI: 10.1016/j.neubiorev.2012.10.005  0.96
2012 Naylor MD, Karlawish JH, Arnold SE, Khachaturian AS, Khachaturian ZS, Lee VM, Baumgart M, Banerjee S, Beck C, Blennow K, Brookmeyer R, Brunden KR, Buckwalter KC, Comer M, Covinsky K, ... ... Paul SM, et al. Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 445-52. PMID 22959699 DOI: 10.1016/j.jalz.2012.08.001  0.96
2012 Khachaturian AS, Paul SM, Khachaturian ZS. NAPA 2.0: the next giant leap. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 379-80. PMID 22959697 DOI: 10.1016/j.jalz.2012.08.002  0.96
2012 Hunter JM, Cirrito JR, Restivo JL, Kinley RD, Sullivan PM, Holtzman DM, Koger D, Delong C, Lin S, Zhao L, Liu F, Bales K, Paul SM. Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice. Brain Research. 1467: 120-32. PMID 22682924 DOI: 10.1016/j.brainres.2012.05.048  0.96
2012 Farlow M, Arnold SE, van Dyck CH, Aisen PS, Snider BJ, Porsteinsson AP, Friedrich S, Dean RA, Gonzales C, Sethuraman G, DeMattos RB, Mohs R, Paul SM, Siemers ER. Safety and biomarker effects of solanezumab in patients with Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 261-71. PMID 22672770 DOI: 10.1016/j.jalz.2011.09.224  0.96
2012 Portelius E, Zetterberg H, Dean RA, Marcil A, Bourgeois P, Nutu M, Andreasson U, Siemers E, Mawuenyega KG, Sigurdson WC, May PC, Paul SM, Holtzman DM, Blennow K, Bateman RJ. Amyloid-β(1-15/16) as a marker for γ-secretase inhibition in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 31: 335-41. PMID 22531418 DOI: 10.3233/JAD-2012-120508  0.96
2011 Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM. Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Science Translational Medicine. 3: 89ra57. PMID 21715678 DOI: 10.1126/scitranslmed.3002156  0.96
2011 Paul SM. Therapeutic antibodies for brain disorders. Science Translational Medicine. 3: 84ps20. PMID 21613621 DOI: 10.1126/scitranslmed.3002620  0.96
2011 Sullivan PM, Han B, Liu F, Mace BE, Ervin JF, Wu S, Koger D, Paul S, Bales KR. Reduced levels of human apoE4 protein in an animal model of cognitive impairment Neurobiology of Aging. 32: 791-801. PMID 19577821 DOI: 10.1016/j.neurobiolaging.2009.05.011  0.96
2010 Hurtado DE, Molina-Porcel L, Iba M, Aboagye AK, Paul SM, Trojanowski JQ, Lee VM. A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model. The American Journal of Pathology. 177: 1977-88. PMID 20802182 DOI: 10.2353/ajpath.2010.100346  0.96
2010 Siemers ER, Friedrich S, Dean RA, Gonzales CR, Farlow MR, Paul SM, Demattos RB. Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease. Clinical Neuropharmacology. 33: 67-73. PMID 20375655 DOI: 10.1097/WNF.0b013e3181cb577a  0.96
2010 Paul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg SR, Schacht AL. How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nature Reviews. Drug Discovery. 9: 203-14. PMID 20168317 DOI: 10.1038/nrd3078  0.96
2010 Eck SL, Paul SM. Biomarker qualification via public-private partnerships. Clinical Pharmacology and Therapeutics. 87: 21-3. PMID 20019697 DOI: 10.1038/clpt.2009.193  0.96
2010 Bateman RJ, Siemers ER, Mawuenyega KG, Sigurdson WC, Yarasheski KE, Friedrich SW, DeMattos RB, May PC, Paul SM, Holtzman DM. Reply Annals of Neurology. 67: 144-145. DOI: 10.1002/ana.21930  0.96
2009 Rohe M, Synowitz M, Glass R, Paul SM, Nykjaer A, Willnow TE. Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15472-8. PMID 20007471 DOI: 10.1523/JNEUROSCI.3960-09.2009  0.96
2009 Kim J, Castellano JM, Jiang H, Basak JM, Parsadanian M, Pham V, Mason SM, Paul SM, Holtzman DM. Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron. 64: 632-44. PMID 20005821 DOI: 10.1016/j.neuron.2009.11.013  0.96
2009 Bales KR, Liu F, Wu S, Lin S, Koger D, DeLong C, Hansen JC, Sullivan PM, Paul SM. Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 6771-9. PMID 19474305 DOI: 10.1523/JNEUROSCI.0887-09.2009  0.96
2009 Bateman RJ, Siemers ER, Mawuenyega KG, Wen G, Browning KR, Sigurdson WC, Yarasheski KE, Friedrich SW, Demattos RB, May PC, Paul SM, Holtzman DM. A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system. Annals of Neurology. 66: 48-54. PMID 19360898 DOI: 10.1002/ana.21623  0.96
2009 Zhao L, Lin S, Bales KR, Gelfanova V, Koger D, Delong C, Hale J, Liu F, Hunter JM, Paul SM. Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 3603-12. PMID 19295164 DOI: 10.1523/JNEUROSCI.5302-08.2009  0.96
2008 Siemers ER, Paul SM. Commentary on "a roadmap for the prevention of dementia: the inaugural Leon Thal Symposium". Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 4: 171-3. PMID 18631964 DOI: 10.1016/j.jalz.2008.03.008  0.96
2008 Rohe M, Carlo AS, Breyhan H, Sporbert A, Militz D, Schmidt V, Wozny C, Harmeier A, Erdmann B, Bales KR, Wolf S, Kempermann G, Paul SM, Schmitz D, Bayer TA, et al. Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis. The Journal of Biological Chemistry. 283: 14826-34. PMID 18362153 DOI: 10.1074/jbc.M710574200  0.96
2008 Wahrle SE, Jiang H, Parsadanian M, Kim J, Li A, Knoten A, Jain S, Hirsch-Reinshagen V, Wellington CL, Bales KR, Paul SM, Holtzman DM. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. The Journal of Clinical Investigation. 118: 671-82. PMID 18202749 DOI: 10.1172/JCI33622  0.96
2008 Zhou Y, Suram A, Venugopal C, Prakasam A, Lin S, Su Y, Li B, Paul SM, Sambamurti K. Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 47-54. PMID 17666454 DOI: 10.1096/fj.07-8175com  0.96
2007 Cao G, Bales KR, DeMattos RB, Paul SM. Liver X receptor-mediated gene regulation and cholesterol homeostasis in brain: relevance to Alzheimer's disease therapeutics. Current Alzheimer Research. 4: 179-84. PMID 17430244 DOI: 10.2174/156720507780362173  0.96
2007 Costa DA, Cracchiolo JR, Bachstetter AD, Hughes TF, Bales KR, Paul SM, Mervis RF, Arendash GW, Potter H. Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms. Neurobiology of Aging. 28: 831-44. PMID 16730391 DOI: 10.1016/j.neurobiolaging.2006.04.009  0.96
2006 Zerbinatti CV, Wahrle SE, Kim H, Cam JA, Bales K, Paul SM, Holtzman DM, Bu G. Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice. The Journal of Biological Chemistry. 281: 36180-6. PMID 17012232 DOI: 10.1074/jbc.M604436200  0.96
2006 Paul SM. Alcohol-sensitive GABA receptors and alcohol antagonists. Proceedings of the National Academy of Sciences of the United States of America. 103: 8307-8. PMID 16717187 DOI: 10.1073/pnas.0602862103  0.96
2006 Bales KR, Tzavara ET, Wu S, Wade MR, Bymaster FP, Paul SM, Nomikos GG. Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A beta antibody. The Journal of Clinical Investigation. 116: 825-32. PMID 16498501 DOI: 10.1172/JCI27120  0.96
2006 Czasch S, Paul S, Baumgärtner W. A comparison of immunohistochemical and silver staining methods for the detection of diffuse plaques in the aged canine brain Neurobiology of Aging. 27: 293-305. PMID 16002188 DOI: 10.1016/j.neurobiolaging.2005.02.017  0.96
2005 Cirrito JR, Yamada KA, Finn MB, Sloviter RS, Bales KR, May PC, Schoepp DD, Paul SM, Mennerick S, Holtzman DM. Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron. 48: 913-22. PMID 16364896 DOI: 10.1016/j.neuron.2005.10.028  0.96
2005 Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. The Journal of Clinical Investigation. 115: 3285-90. PMID 16239972 DOI: 10.1172/JCI25247  0.96
2005 Esh C, Patton L, Kalback W, Kokjohn TA, Lopez J, Brune D, Newell AJ, Beach T, Schenk D, Games D, Paul S, Bales K, Ghetti B, Castaño EM, Roher AE. Altered APP processing in PDAPP (Val717 --> Phe) transgenic mice yields extended-length Abeta peptides. Biochemistry. 44: 13807-19. PMID 16229470 DOI: 10.1021/bi051213+  0.96
2005 Wahrle SE, Jiang H, Parsadanian M, Hartman RE, Bales KR, Paul SM, Holtzman DM. Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. The Journal of Biological Chemistry. 280: 43236-42. PMID 16207708 DOI: 10.1074/jbc.M508780200  0.96
2005 Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CA, Breiderhoff T, Jansen P, Wu X, Bales KR, Cappai R, Masters CL, Gliemann J, Mufson EJ, ... ... Paul SM, et al. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 102: 13461-6. PMID 16174740 DOI: 10.1073/pnas.0503689102  0.96
2005 Lin S, Wei X, Bales KR, Paul AB, Ma Z, Yan G, Paul SM, Du Y. Minocycline blocks bilirubin neurotoxicity and prevents hyperbilirubinemia-induced cerebellar hypoplasia in the Gunn rat. The European Journal of Neuroscience. 22: 21-7. PMID 16029192 DOI: 10.1111/j.1460-9568.2005.04182.x  0.96
2005 Hartman RE, Izumi Y, Bales KR, Paul SM, Wozniak DF, Holtzman DM. Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6213-20. PMID 15987951 DOI: 10.1523/JNEUROSCI.0664-05.2005  0.96
2005 Du Y, Chen X, Wei X, Bales KR, Berg DT, Paul SM, Farlow MR, Maloney B, Ge YW, Lahiri DK. NF-(kappa)B mediates amyloid beta peptide-stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells. Brain Research. Molecular Brain Research. 136: 177-88. PMID 15893602 DOI: 10.1016/j.molbrainres.2005.02.001  0.96
2005 Fryer JD, Demattos RB, McCormick LM, O'Dell MA, Spinner ML, Bales KR, Paul SM, Sullivan PM, Parsadanian M, Bu G, Holtzman DM. The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. The Journal of Biological Chemistry. 280: 25754-9. PMID 15888448 DOI: 10.1074/jbc.M502143200  0.96
2005 Fryer JD, Simmons K, Parsadanian M, Bales KR, Paul SM, Sullivan PM, Holtzman DM. Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2803-10. PMID 15772340 DOI: 10.1523/JNEUROSCI.5170-04.2005  0.96
2005 Green PS, Bales K, Paul S, Bu G. Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer's disease Endocrinology. 146: 2774-2781. PMID 15731362 DOI: 10.1210/en.2004-1433  0.96
2005 Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, Klunk WE, Mathis CA, Bales KR, Paul SM, Hyman BT, Holtzman DM. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. The Journal of Clinical Investigation. 115: 428-33. PMID 15668737 DOI: 10.1172/JCI23269  0.96
2005 Racke MM, Boone LI, Hepburn DL, Parsadainian M, Bryan MT, Ness DK, Piroozi KS, Jordan WH, Brown DD, Hoffman WP, Holtzman DM, Bales KR, Gitter BD, May PC, Paul SM, et al. Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 629-36. PMID 15659599 DOI: 10.1523/JNEUROSCI.4337-04.2005  0.96
2005 Dodart JC, Marr RA, Koistinaho M, Gregersen BM, Malkani S, Verma IM, Paul SM. Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 102: 1211-6. PMID 15657137 DOI: 10.1073/pnas.0409072102  0.96
2004 Costa DA, Nilsson LN, Bales KR, Paul SM, Potter H. Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 6: 509-14. PMID 15505373  0.96
2004 Fagan AM, Christopher E, Taylor JW, Parsadanian M, Spinner M, Watson M, Fryer JD, Wahrle S, Bales KR, Paul SM, Holtzman DM. ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis. The American Journal of Pathology. 165: 1413-22. PMID 15466405  0.96
2004 Nilsson LN, Arendash GW, Leighty RE, Costa DA, Low MA, Garcia MF, Cracciolo JR, Rojiani A, Wu X, Bales KR, Paul SM, Potter H. Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation. Neurobiology of Aging. 25: 1153-67. PMID 15312961 DOI: 10.1016/j.neurobiolaging.2003.12.011  0.96
2004 Leighty RE, Nilsson LN, Potter H, Costa DA, Low MA, Bales KR, Paul SM, Arendash GW. Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer's transgenic mouse lines differing in Abeta deposition. Behavioural Brain Research. 153: 107-21. PMID 15219712 DOI: 10.1016/j.bbr.2003.11.004  0.96
2004 Koistinaho M, Lin S, Wu X, Esterman M, Koger D, Hanson J, Higgs R, Liu F, Malkani S, Bales KR, Paul SM. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides. Nature Medicine. 10: 719-26. PMID 15195085 DOI: 10.1038/nm1058  0.96
2004 Su Y, Ryder J, Li B, Wu X, Fox N, Solenberg P, Brune K, Paul S, Zhou Y, Liu F, Ni B. Lithium, a common drug for bipolar disorder treatment, regulates amyloid-β precursor protein processing Biochemistry. 43: 6899-6908. PMID 15170327 DOI: 10.1021/bi035627j  0.96
2004 DeMattos RB, Cirrito JR, Parsadanian M, May PC, O'Dell MA, Taylor JW, Harmony JA, Aronow BJ, Bales KR, Paul SM, Holtzman DM. ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron. 41: 193-202. PMID 14741101 DOI: 10.1016/S0896-6273(03)00850-X  0.96
2004 Zerbinatti CV, Wozniak DF, Cirrito J, Cam JA, Osaka H, Bales KR, Zhuo M, Paul SM, Holtzman DM, Bu G. Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Proceedings of the National Academy of Sciences of the United States of America. 101: 1075-80. PMID 14732699 DOI: 10.1073/pnas.0305803101  0.96
2004 Liang Y, Lin S, Beyer TP, Zhang Y, Wu X, Bales KR, DeMattos RB, May PC, Li SD, Jiang XC, Eacho PI, Cao G, Paul SM. A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes. Journal of Neurochemistry. 88: 623-34. PMID 14720212 DOI: 10.1111/j.1471-4159.2004.02183.x  0.96
2003 Lin S, Yan C, Wei X, Paul SM, Du Y. p38 MAP kinase mediates bilirubin-induced neuronal death of cultured rat cerebellar granule neurons. Neuroscience Letters. 353: 209-12. PMID 14665418 DOI: 10.1016/j.neulet.2003.09.053  0.96
2003 Brendza RP, Simmons K, Bales KR, Paul SM, Goldberg MP, Holtzman DM. Use of YFP to study amyloid-beta associated neurite alterations in live brain slices. Neurobiology of Aging. 24: 1071-7. PMID 14643378 DOI: 10.1016/j.neurobiolaging.2003.04.008  0.96
2003 Cirrito JR, May PC, O'Dell MA, Taylor JW, Parsadanian M, Cramer JW, Audia JE, Nissen JS, Bales KR, Paul SM, DeMattos RB, Holtzman DM. In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8844-53. PMID 14523085  0.96
2003 Fryer JD, Taylor JW, DeMattos RB, Bales KR, Paul SM, Parsadanian M, Holtzman DM. Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7889-96. PMID 12944519  0.96
2003 Saura J, Petegnief V, Wu X, Liang Y, Paul SM. Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide. Journal of Neurochemistry. 85: 1455-67. PMID 12787065 DOI: 10.1046/j.1471-4159.2003.01788.x  0.96
2003 Dodart JC, Bales KR, Paul SM. Immunotherapy for Alzheimer's disease: will vaccination work? Trends in Molecular Medicine. 9: 85-7. PMID 12657428 DOI: 10.1016/S1471-4914(03)00022-4  0.96
2003 Brendza RP, O'Brien C, Simmons K, McKeel DW, Bales KR, Paul SM, Olney JW, Sanes JR, Holtzman DM. PDAPP; YFP double transgenic mice: a tool to study amyloid-beta associated changes in axonal, dendritic, and synaptic structures. The Journal of Comparative Neurology. 456: 375-83. PMID 12532409 DOI: 10.1002/cne.10536  0.96
2002 Bales KR, Dodart JC, DeMattos RB, Holtzman DM, Paul SM. Apolipoprotein E, amyloid, and Alzheimer disease. Molecular Interventions. 2: 363-75, 339. PMID 14993413 DOI: 10.1124/mi.2.6.363  0.96
2002 Dodart JC, Mathis C, Bales KR, Paul SM. Does my mouse have Alzheimer's disease? Genes, Brain, and Behavior. 1: 142-55. PMID 12884970 DOI: 10.1034/j.1601-183X.2002.10302.x  0.96
2002 Hartman RE, Laurer H, Longhi L, Bales KR, Paul SM, McIntosh TK, Holtzman DM. Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10083-7. PMID 12451108  0.96
2002 Dodart JC, Bales KR, Johnstone EM, Little SP, Paul SM. Apolipoprotein E alters the processing of the beta-amyloid precursor protein in APP(V717F) transgenic mice. Brain Research. 955: 191-9. PMID 12419536 DOI: 10.1016/S0006-8993(02)03437-6  0.96
2002 Gao F, Bales KR, Dodel RC, Liu J, Chen X, Hample H, Farlow MR, Paul SM, Du Y. NF-kappaB mediates IL-1beta-induced synthesis/release of alpha2-macroglobulin in a human glial cell line. Brain Research. Molecular Brain Research. 105: 108-14. PMID 12399113 DOI: 10.1016/S0169-328X(02)00398-4  0.96
2002 Tamminga CA, Nemeroff CB, Blakely RD, Brady L, Carter CS, Davis KL, Dingledine R, Gorman JM, Grigoriadis DE, Henderson DC, B Innis RB, Killen J, Laughren TP, McDonald WM, M Murphy GM, ... Paul SM, et al. Developing novel treatments for mood disorders: accelerating discovery. Biological Psychiatry. 52: 589-609. PMID 12361670 DOI: 10.1016/S0006-3223(02)01470-1  0.96
2002 DeMattos RB, O'dell MA, Parsadanian M, Taylor JW, Harmony JA, Bales KR, Paul SM, Aronow BJ, Holtzman DM. Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 10843-8. PMID 12145324 DOI: 10.1073/pnas.162228299  0.96
2002 Arvin KL, Han BH, Du Y, Lin SZ, Paul SM, Holtzman DM. Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury. Annals of Neurology. 52: 54-61. PMID 12112047 DOI: 10.1002/ana.10242  0.96
2002 DeMattos RB, Bales KR, Parsadanian M, O'Dell MA, Foss EM, Paul SM, Holtzman DM. Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease. Journal of Neurochemistry. 81: 229-36. PMID 12064470 DOI: 10.1046/j.1471-4159.2002.00889.x  0.96
2002 Fagan AM, Watson M, Parsadanian M, Bales KR, Paul SM, Holtzman DM. Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiology of Disease. 9: 305-18. PMID 11950276 DOI: 10.1006/nbdi.2002.0483  0.96
2002 Dodart JC, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, DeLong CA, Wu S, Wu X, Holtzman DM, Paul SM. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nature Neuroscience. 5: 452-7. PMID 11941374 DOI: 10.1038/nn842  0.96
2002 DeMattos RB, Bales KR, Cummins DJ, Paul SM, Holtzman DM. Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science (New York, N.Y.). 295: 2264-7. PMID 11910111 DOI: 10.1126/science.1067568  0.96
2002 Holtzman DM, Bales KR, Paul SM, DeMattos RB. Aβ immunization and anti-Aβ antibodies: Potential therapies for the prevention and treatment of Alzheimer's disease Advanced Drug Delivery Reviews. 54: 1603-1613. DOI: 10.1016/S0169-409X(02)00158-8  0.96
2001 Sheng JG, Mrak RE, Jones RA, Brewer MM, Zhou XQ, McGinness J, Woodward S, Bales K, Paul SM, Cordell B, Griffin WS. Neuronal DNA damage correlates with overexpression of interleukin-1beta converting enzyme in APPV717F mice. Neurobiology of Aging. 22: 895-902. PMID 11754996 DOI: 10.1016/S0197-4580(01)00298-6  0.96
2001 Du Y, Ma Z, Lin S, Dodel RC, Gao F, Bales KR, Triarhou LC, Chernet E, Perry KW, Nelson DL, Luecke S, Phebus LA, Bymaster FP, Paul SM. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 14669-74. PMID 11724929 DOI: 10.1073/pnas.251341998  0.96
2001 Lin S, Zhang Y, Dodel R, Farlow MR, Paul SM, Du Y. Minocycline blocks nitric oxide-induced neurotoxicity by inhibition p38 MAP kinase in rat cerebellar granule neurons. Neuroscience Letters. 315: 61-4. PMID 11711215 DOI: 10.1016/S0304-3940(01)02324-2  0.96
2001 Qiao X, Cummins DJ, Paul SM. Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse. The European Journal of Neuroscience. 14: 474-82. PMID 11553297 DOI: 10.1046/j.0953-816X.2001.01666.x  0.96
2001 Du Y, Dodel R, Hampel H, Buerger K, Lin S, Eastwood B, Bales K, Gao F, Moeller HJ, Oertel W, Farlow M, Paul S. Reduced levels of amyloid β-peptide antibody in Alzheimer disease Neurology. 57: 801-805. PMID 11552007  0.96
2001 Fishman CE, Cummins DJ, Bales KR, DeLong CA, Esterman MA, Hanson JC, White SL, Paul SM, Jordan WH. Statistical aspects of quantitative image analysis of beta-amyloid in the APP(V717F) transgenic mouse model of Alzheimer's disease. Journal of Neuroscience Methods. 108: 145-52. PMID 11478973 DOI: 10.1016/S0165-0270(01)00381-8  0.96
2001 DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 8850-5. PMID 11438712 DOI: 10.1073/pnas.151261398  0.96
2001 Naidu A, Catalano R, Bales K, Wu S, Paul SM, Cordell B. Conversion of brain apolipoprotein E to an insoluble form in a mouse model of Alzheimer disease. Neuroreport. 12: 1265-70. PMID 11338204  0.96
2001 Petegnief V, Saura J, De Gregorio-Rocasolano N, Paul SM. Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: Nuclear factor κB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E Neuroscience. 104: 223-234. PMID 11311545 DOI: 10.1016/S0306-4522(01)00046-X  0.96
2001 Nilsson LN, Bales KR, DiCarlo G, Gordon MN, Morgan D, Paul SM, Potter H. Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1444-51. PMID 11222634  0.96
2000 Irizarry MC, Rebeck GW, Cheung B, Bales K, Paul SM, Holzman D, Hyman BT. Modulation of Aβ deposition in APP transgenic mice by an apolipoprotein E null background Annals of the New York Academy of Sciences. 920: 171-178. PMID 11193147  0.96
2000 Irizarry MC, Cheung BS, Rebeck GW, Paul SM, Bales KR, Hyman BT. Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid β-peptide deposition in homozygous APP(V717F) transgenic mice Acta Neuropathologica. 100: 451-458. PMID 11045665 DOI: 10.1007/s004010000263  0.96
2000 Du Y, Dodel RC, Eastwood BJ, Bales KR, Gao F, Lohmüller F, Müller U, Kurz A, Zimmer R, Evans RM, Hake A, Gasser T, Oertel WH, Griffin WS, Paul SM, et al. Association of an interleukin 1 alpha polymorphism with Alzheimer's disease. Neurology. 55: 480-3. PMID 10953177  0.96
1998 Montpied P, Yan GM, Paul SM, Morrow AL. Transient increase in cerebellar transcriptional activity precedes the expression of GABA(A) receptor alpha6 subunit mRNA during postnatal maturation. Developmental Neuroscience. 20: 74-82. PMID 9600393  0.96
1995 Morrow AL, Devaud LL, Purdy RH, Paul SM. Neuroactive steroid modulators of the stress response. Annals of the New York Academy of Sciences. 771: 257-72. PMID 8597405 DOI: 10.1111/j.1749-6632.1995.tb44687.x  0.96
1993 Montpied P, Weizman A, Weizman R, Kook KA, Morrow AL, Paul SM. Repeated swim-stress reduces GABAA receptor alpha subunit mRNAs in the mouse hippocampus. Brain Research. Molecular Brain Research. 18: 267-72. PMID 7684486  0.96
1992 Purdy RH, Moore PH, Morrow AL, Paul SM. Neurosteroids and GABAA receptor function. Advances in Biochemical Psychopharmacology. 47: 87-92. PMID 1354922  0.96
1991 Purdy RH, Morrow AL, Moore PH, Paul SM. Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain. Proceedings of the National Academy of Sciences of the United States of America. 88: 4553-7. PMID 1852011  0.96
1991 Morrow AL, Montpied P, Paul SM. GABAA receptor function and expression following chronic ethanol and barbiturate administration. Annals of the New York Academy of Sciences. 625: 496-507. PMID 1711815  0.96
1991 Montpied P, Morrow AL, Karanian JW, Ginns EI, Martin BM, Paul SM. Prolonged ethanol inhalation decreases gamma-aminobutyric acidA receptor alpha subunit mRNAs in the rat cerebral cortex. Molecular Pharmacology. 39: 157-63. PMID 1705000  0.96
1990 Purdy RH, Morrow AL, Blinn JR, Paul SM. Synthesis, metabolism, and pharmacological activity of 3 alpha-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes. Journal of Medicinal Chemistry. 33: 1572-81. PMID 2160534  0.96
1990 Morrow AL, Montpied P, Lingford-Hughes A, Paul SM. Chronic ethanol and pentobarbital administration in the rat: effects on GABAA receptor function and expression in brain. Alcohol (Fayetteville, N.Y.). 7: 237-44. PMID 2158791  0.96
1990 Purdy RH, Moore PH, Rao PN, Hagino N, Yamaguchi T, Schmidt P, Rubinow DR, Morrow AL, Paul SM. Radioimmunoassay of 3 alpha-hydroxy-5 alpha-pregnan-20-one in rat and human plasma. Steroids. 55: 290-6. PMID 2120801  0.96
1990 Baker BL, Morrow AL, Vergalla J, Paul SM, Jones EA. Gamma-aminobutyric acid (GABAA) receptor-function in a rat model of hepatic encephalopathy. Metabolic Brain Disease. 5: 185-93. PMID 1965008 DOI: 10.1007/BF00997072  0.96
1990 Morrow AL, Pace JR, Purdy RH, Paul SM. Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites. Molecular Pharmacology. 37: 263-70. PMID 1689453  0.96
1989 Drugan RC, Morrow AL, Weizman R, Weizman A, Deutsch SI, Crawley JN, Paul SM. Stress-induced behavioral depression in the rat is associated with a decrease in GABA receptor-mediated chloride ion flux and brain benzodiazepine receptor occupancy. Brain Research. 487: 45-51. PMID 2546650 DOI: 10.1016/0006-8993(89)90938-4  0.96
1988 Morrow AL, Paul SM. Benzodiazepine enhancement of gamma-aminobutyric acid-mediated chloride ion flux in rat brain synaptoneurosomes. Journal of Neurochemistry. 50: 302-6. PMID 3335847  0.96
1988 Morrow AL, Suzdak PD, Paul SM. Benzodiazepine, barbiturate, ethanol and hypnotic steroid hormone modulation of GABA-mediated chloride ion transport in rat brain synaptoneurosomes. Advances in Biochemical Psychopharmacology. 45: 247-61. PMID 2902744  0.96
1988 Morrow AL, Suzdak PD, Karanian JW, Paul SM. Chronic ethanol administration alters gamma-aminobutyric acid, pentobarbital and ethanol-mediated 36Cl- uptake in cerebral cortical synaptoneurosomes. The Journal of Pharmacology and Experimental Therapeutics. 246: 158-64. PMID 2839659  0.96
1987 Luu MD, Morrow AL, Paul SM, Schwartz RD. Characterization of GABAA receptor-mediated 36chloride uptake in rat brain synaptoneurosomes. Life Sciences. 41: 1277-87. PMID 3041140  0.96
1987 Morrow AL, Suzdak PD, Paul SM. Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency. European Journal of Pharmacology. 142: 483-5. PMID 2828079  0.96
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