Valina L. Dawson - Related publications

Johns Hopkins University School of Medicine, Baltimore, MD, United States 
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Zang CX, Wang L, Yang HY, Shang JM, Liu H, Zhang ZH, Ju C, Yuan FY, Li FY, Bao XQ, Zhang D. HACE1 negatively regulates neuroinflammation through ubiquitylating and degrading Rac1 in Parkinson's disease models. Acta Pharmacologica Sinica. PMID 34593974 DOI: 10.1038/s41401-021-00778-2   
2021 Kung HC, Lin KJ, Kung CT, Lin TK. Oxidative Stress, Mitochondrial Dysfunction, and Neuroprotection of Polyphenols with Respect to Resveratrol in Parkinson's Disease. Biomedicines. 9. PMID 34440122 DOI: 10.3390/biomedicines9080918   
2021 Behl T, Madaan P, Sehgal A, Singh S, Sharma N, Bhatia S, Al-Harrasi A, Chigurupati S, Alrashdi I, Bungau SG. Elucidating the Neuroprotective Role of PPARs in Parkinson's Disease: A Neoteric and Prospective Target. International Journal of Molecular Sciences. 22. PMID 34576325 DOI: 10.3390/ijms221810161   
2021 Guo Y, Ma Z, Ning X, Chen Y, Tian C, Wang X, Zhang Z, Liu J. A Novel Synthetic Precursor of Styryl Sulfone Neuroprotective Agents Inhibits Neuroinflammatory Responses and Oxidative Stress Damage through the P38 Signaling Pathway in the Cell and Animal Model of Parkinson's Disease. Molecules (Basel, Switzerland). 26. PMID 34500807 DOI: 10.3390/molecules26175371   
2021 Chen Z, Rasheed M, Deng Y. The epigenetic mechanisms involved in mitochondrial dysfunction: Implication for Parkinson's disease. Brain Pathology (Zurich, Switzerland). e13012. PMID 34414627 DOI: 10.1111/bpa.13012   
2021 Mani S, Sevanan M, Krishnamoorthy A, Sekar S. A systematic review of molecular approaches that link mitochondrial dysfunction and neuroinflammation in Parkinson's disease. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. PMID 34480241 DOI: 10.1007/s10072-021-05551-1   
2021 Lengyel-Zhand Z, Puentes LN, Mach RH. PARkinson's: From cellular mechanisms to potential therapeutics. Pharmacology & Therapeutics. 107968. PMID 34391789 DOI: 10.1016/j.pharmthera.2021.107968   
2021 Ahn EH, Lei K, Kang SS, Wang ZH, Liu X, Hong W, Wang YT, Edgington-Mitchell LE, Jin L, Ye K. Mitochondrial dysfunction triggers the pathogenesis of Parkinson's disease in neuronal C/EBPβ transgenic mice. Molecular Psychiatry. PMID 34489530 DOI: 10.1038/s41380-021-01284-x   
2021 Burtscher J, Syed MMK, Keller MA, Lashuel HA, Millet GP. Fatal attraction - The role of hypoxia when alpha-synuclein gets intimate with mitochondria. Neurobiology of Aging. 107: 128-141. PMID 34428721 DOI: 10.1016/j.neurobiolaging.2021.07.017   
2021 Guo Q, Wang B, Wang X, Smith WW, Zhu Y, Liu Z. Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models. Cells. 10. PMID 34440619 DOI: 10.3390/cells10081850   
2021 Seo MH, Yeo S. Decrease Associated with Alpha-Synuclein Increase in Muscles of MPTP-Induced Parkinson's Disease Mice. International Journal of Molecular Sciences. 22. PMID 34502283 DOI: 10.3390/ijms22179375   
2021 Martín-Montañez E, Valverde N, Ladrón de Guevara-Miranda D, Lara E, Romero-Zerbo YS, Millon C, Boraldi F, Ávila-Gámiz F, Pérez-Cano AM, Garrido-Gil P, Labandeira-Garcia JL, Santin LJ, Pavia J, Garcia-Fernandez M. Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson's disease. Redox Biology. 46: 102095. PMID 34418603 DOI: 10.1016/j.redox.2021.102095   
2021 SenGupta T, Palikaras K, Esbensen YQ, Konstantinidis G, Galindo FJN, Achanta K, Kassahun H, Stavgiannoudaki I, Bohr VA, Akbari M, Gaare J, Tzoulis C, Tavernarakis N, Nilsen H. Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology. Cell Reports. 36: 109668. PMID 34496255 DOI: 10.1016/j.celrep.2021.109668   
2021 Bai X, Zhang X, Fang R, Wang J, Ma Y, Liu Z, Dong H, Li Q, Ge J, Yu M, Fei J, Sun R, Huang F. Deficiency of leads to accelerated aging and neuroprotection in MPTP-induced Parkinson's disease mice. Aging. 13. PMID 34543233 DOI: 10.18632/aging.203545   
2021 Rosenbusch KE, Oun A, Sanislav O, Lay ST, Keizer-Gunnink I, Annesley SJ, Fisher PR, Dolga AM, Kortholt A. A Conserved Role for LRRK2 and Roco Proteins in the Regulation of Mitochondrial Activity. Frontiers in Cell and Developmental Biology. 9: 734554. PMID 34568343 DOI: 10.3389/fcell.2021.734554   
2021 Fenner BM, Fenner ME, Prowse N, Hayley SP. LRRK2 and WAVE2 regulate microglial-transition through distinct morphological phenotypes to induce neurotoxicity in a novel two-hit in vitro model of neurodegeneration. Journal of Cellular Physiology. PMID 34543438 DOI: 10.1002/jcp.30588   
2021 Chen S, Annesley SJ, Jasim RAF, Fisher PR. The Parkinson's Disease-Associated Protein DJ-1 Protects Cells from AMPK-Dependent Outcomes of Oxidative Stress. Cells. 10. PMID 34440642 DOI: 10.3390/cells10081874   
2021 Lestón Pinilla L, Ugun-Klusek A, Rutella S, De Girolamo LA. Hypoxia Signaling in Parkinson's Disease: There Is Use in Asking "What HIF?" Biology. 10. PMID 34439955 DOI: 10.3390/biology10080723   
2021 Wang S, Wen Q, Xiong B, Zhang L, Yu X, Ouyang X. LncRNA NEAT1 knockdown ameliorates MPP-induced cell injury through miR-519a-3p/SP1 axis in Parkinson's disease. World Neurosurgery. PMID 34508910 DOI: 10.1016/j.wneu.2021.08.147   
2021 Clarke E, Eriksen JG, Barrett S. The effects of PD-1/PD-L1 checkpoint inhibitors on recurrent/metastatic head and neck squamous cell carcinoma: a critical review of the literature and meta-analysis. Acta Oncologica (Stockholm, Sweden). 1-9. PMID 34410881 DOI: 10.1080/0284186X.2021.1964699   
2021 Huang Y, Liu Y, Huang J, Gao L, Wu Z, Wang L, Fan L. Let‑7b‑5p promotes cell apoptosis in Parkinson's disease by targeting HMGA2. Molecular Medicine Reports. 24. PMID 34558637 DOI: 10.3892/mmr.2021.12461   
2021 Yang X, Zhang Y, Chen Y, He X, Qian Y, Xu S, Gao C, Mo C, Chen S, Xiao Q. LncRNA HOXA-AS2 regulates microglial polarization via recruitment of PRC2 and epigenetic modification of PGC-1α expression. Journal of Neuroinflammation. 18: 197. PMID 34511122 DOI: 10.1186/s12974-021-02267-z   
2021 Xu PC, Luan Y, Yu SY, Xu J, Coulter DW, Kim SY. Effects of PD-1 blockade on ovarian follicles in a prepubertal female mouse. The Journal of Endocrinology. PMID 34647523 DOI: 10.1530/JOE-21-0209   
2021 Xu Z, Qu A, Wang W, Lu M, Shi B, Chen C, Hao C, Xu L, Sun M, Xu C, Kuang H. Facet-dependent Biodegradable Mn O Nanoparticles for Ameliorating Parkinson's Disease. Advanced Healthcare Materials. e2101316. PMID 34601811 DOI: 10.1002/adhm.202101316   
2021 Youssef N, Noureldein M, Daoud G, Eid AA. Immune checkpoint inhibitors and diabetes: Mechanisms and predictors. Diabetes & Metabolism. 47: 101193. PMID 33010422 DOI: 10.1016/j.diabet.2020.09.003   
2021 Assi HH, Wong C, Tipton KA, Mei L, Wong K, Razo J, Chan C, Howng B, Sagert J, Krimm M, Diep L, Jang A, Nguyen MT, Lapuyade N, Singson V, et al. Conditional PD-1/PD-L1 Probody therapeutics induce comparable antitumor immunity but reduced systemic toxicity compared with traditional anti-PD 1/PD-L1 agents. Cancer Immunology Research. PMID 34635485 DOI: 10.1158/2326-6066.CIR-21-0031   
2021 Li DW, Qi XD, Zhang CH, Sun WP. Annexin A2 degradation contributes to dopaminergic cell apoptosis via regulating p53 in neurodegenerative conditions. Neuroreport. PMID 34494994 DOI: 10.1097/WNR.0000000000001721   
2021 Lee EJ, Kim JH, Kim TI, Kim YJ, Pak ME, Jeon CH, Park YJ, Li W, Kim YS, Choi JG, Chung HS. Sanguisorbae Radix Suppresses Colorectal Tumor Growth Through PD-1/PD-L1 Blockade and Synergistic Effect With Pembrolizumab in a Humanized PD-L1-Expressing Colorectal Cancer Mouse Model. Frontiers in Immunology. 12: 737076. PMID 34659228 DOI: 10.3389/fimmu.2021.737076   
2021 Mazza MC, Beilina A, Roosen DA, Hauser D, Cookson MR. Generation of iPSC line from a Parkinson patient with PARK7 mutation and CRISPR-edited Gibco human episomal iPSC line to mimic PARK7 mutation. Stem Cell Research. 55: 102506. PMID 34419745 DOI: 10.1016/j.scr.2021.102506   
2021 Sun L, Jiang WW, Wang Y, Yuan YS, Rong Z, Wu J, Fan Y, Lu M, Zhang KZ. Phosphorylated α-synuclein aggregated in Schwann cells exacerbates peripheral neuroinflammation and nerve dysfunction in Parkinson's disease through TLR2/NF-κB pathway. Cell Death Discovery. 7: 289. PMID 34642321 DOI: 10.1038/s41420-021-00676-w   
2021 Asanuma M, Miyazaki I. Glutathione and Related Molecules in Parkinsonism. International Journal of Molecular Sciences. 22. PMID 34445395 DOI: 10.3390/ijms22168689   
2021 Nakajima M, Matsuyama M, Kawaguchi M, Matsumura S, Kiwamoto T, Matsuno Y, Morishima Y, Yoshida K, Sherpa MT, Yazaki K, Tanaka R, Okiyama N, Muratani M, Ishii Y, Hizawa N. Depletion of PD-1 or PD-L1 did not affect the mortality of mice infected with Mycobacterium avium. Scientific Reports. 11: 18008. PMID 34504192 DOI: 10.1038/s41598-021-97391-4   
2021 Ahn A, Rodger EJ, Motwani J, Gimenez G, Stockwell PA, Parry M, Hersey P, Chatterjee A, Eccles MR. Transcriptional Reprogramming and Constitutive PD-L1 Expression in Melanoma Are Associated with Dedifferentiation and Activation of Interferon and Tumour Necrosis Factor Signalling Pathways. Cancers. 13. PMID 34503064 DOI: 10.3390/cancers13174250   
2021 Kawabata M, Inoue N, Watanabe M, Kobayashi A, Hidaka Y, Miyauchi A, Iwatani Y. gene polymorphisms and thyroid expression of PD-1 ligands differ between Graves' and Hashimoto's diseases. Autoimmunity. 1-10. PMID 34494503 DOI: 10.1080/08916934.2021.1946796   
2021 Hu X, Lin Z, Wang Z, Zhou Q. Emerging role of PD-L1 modification in cancer immunotherapy. American Journal of Cancer Research. 11: 3832-3840. PMID 34522452   
2021 Ge X, Wang Y, Yu S, Cao X, Chen Y, Cheng Q, Ding F. Anti-inflammatory Activity of a Polypeptide Fraction From in Amyloid β Oligomers Induced Model of Alzheimer's Disease. Frontiers in Pharmacology. 12: 716177. PMID 34456729 DOI: 10.3389/fphar.2021.716177   
2021 Solano Fonseca R, Metang P, Egge N, Liu Y, Zuurbier KR, Sivaprakasam K, Shirazi S, Chuah A, Arneaud SL, Konopka G, Qian D, Douglas PM. Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration. Elife. 10. PMID 34473622 DOI: 10.7554/eLife.69438   
2021 Papageorgiou GI, Fergadis E, Skouteris N, Christakos E, Tsakatikas SA, Filippakou A, Papantoni E, Stanc G, Souka E, Valavanis C, Kosmas C. Perforated appendicitis induced by pembrolizumab: a case report and review of the literature. Anti-Cancer Drugs. PMID 34538865 DOI: 10.1097/CAD.0000000000001247   
2021 O'Connell TJ, Dadafarin S, Jones M, Rodríguez T, Gupta A, Shin E, Moscatello A, Iacob C, Islam H, Tiwari RK, Geliebter J. Androgen Activity Is Associated With PD-L1 Downregulation in Thyroid Cancer. Frontiers in Cell and Developmental Biology. 9: 663130. PMID 34422798 DOI: 10.3389/fcell.2021.663130   
2021 Wang JF, Wang YP, Xie J, Zhao ZZ, Gupta S, Guo Y, Jia SH, Parodo J, Marshall JC, Deng XM. Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental mouse model of sepsis. Blood. 138: 806-810. PMID 34473230 DOI: 10.1182/blood.2020009417   
2021 Chen Q, Li Y, Zhang W, Yang S, Wang C, Guo Q, Shi W. [Clinical Analysis of Docetaxel Combined with PD-1/PD-L1 Inhibitor in Second-line Treatment of Advanced Non-small Cell Lung Cancer]. Zhongguo Fei Ai Za Zhi = Chinese Journal of Lung Cancer. PMID 34455735 DOI: 10.3779/j.issn.1009-3419.2021.102.26   
2021 Park JM, Han YM, Hahm KB. Rejuvenation of -Associated Atrophic Gastritis Through Concerted Actions of Placenta-Derived Mesenchymal Stem Cells Prevented Gastric Cancer. Frontiers in Pharmacology. 12: 675443. PMID 34483897 DOI: 10.3389/fphar.2021.675443   
2021 Gerhard-Hartmann E, Goergen H, Bröckelmann PJ, Mottok A, Steinmüller T, Grund J, Zamò A, Ben-Neriah S, Sasse S, Borchmann S, Fuchs M, Borchmann P, Reinke S, Engert A, Veldman J, et al. 9p24.1 alterations and programmed cell death 1 ligand 1 expression in early stage unfavourable classical Hodgkin lymphoma: an analysis from the German Hodgkin Study Group NIVAHL trial. British Journal of Haematology. PMID 34520052 DOI: 10.1111/bjh.17793   
2021 Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D. Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro. Molecules (Basel, Switzerland). 26. PMID 34577027 DOI: 10.3390/molecules26185558   
2021 Kawashita S, Aoyagi K, Fukushima K, Hantani R, Naruoka S, Tanimoto A, Hori Y, Toyonaga Y, Yamanaka H, Miyazaki S, Hantani Y. SAR study of small molecule inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction. Chemical Biology & Drug Design. PMID 34495575 DOI: 10.1111/cbdd.13949   
2021 Xu F, Fei Z, Dai H, Xu J, Fan Q, Shen S, Zhang Y, Ma Q, Chu J, Peng F, Zhou F, Liu Z, Wang C. Mesenchymal Stem Cell-derived Extracellular Vesicles with High PD-L1 Expression for Autoimmune Diseases Treatment. Advanced Materials (Deerfield Beach, Fla.). e2106265. PMID 34613627 DOI: 10.1002/adma.202106265   
2021 Fang Y, Wang X, Yang D, Lu Y, Wei G, Yu W, Liu X, Zheng Q, Ying J, Hua F. Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node. Frontiers in Aging Neuroscience. 13: 738686. PMID 34616289 DOI: 10.3389/fnagi.2021.738686   
2021 Huang X, Chen H, Dai X, Xu M, Wang K, Feng Z. Design, synthesis, and structure-activity relationship of PD-1/PD-L1 inhibitors with a benzo[d]isoxazole scaffold. Bioorganic & Medicinal Chemistry Letters. 128403. PMID 34610423 DOI: 10.1016/j.bmcl.2021.128403   
2021 Garcia S, Saldana-Caboverde A, Anwar M, Raval AP, Nissanka N, Pinto M, Moraes CT, Diaz F. Enhanced glycolysis and GSK3 inactivation promote brain metabolic adaptations following neuronal mitochondrial stress. Human Molecular Genetics. PMID 34559217 DOI: 10.1093/hmg/ddab282   
2021 Shen X, Wang Y, Jin Y, Zheng Q, Shen L, Chen Y, Li Y. PD-L1 expression in non-small cell lung cancer: heterogeneity by pathologic types, tissue sampling and metastasis. Journal of Thoracic Disease. 13: 4360-4370. PMID 34422362 DOI: 10.21037/jtd-21-388