Leonard K. Kaczmarek - Related publications

Affiliations: 
Yale University, New Haven, CT 
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Mishra P, Narayanan R. Ion-channel degeneracy: Multiple ion channels heterogeneously regulate intrinsic physiology of rat hippocampal granule cells. Physiological Reports. 9: e14963. PMID 34342171 DOI: 10.14814/phy2.14963   
2021 López X, Palacios-Prado N, Güiza J, Escamilla R, Fernández P, Vega JL, Rojas M, Marquez-Miranda V, Chamorro E, Cárdenas AM, Maldifassi MC, Martínez AD, Duarte Y, González-Nilo FD, Sáez JC. A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34301850 DOI: 10.1073/pnas.2108967118   
2021 Chen WB, Wang YX, Wang HG, An D, Sun D, Li P, Zhang T, Lu WG, Liu YQ. TPEN attenuates amyloid-β-induced neuronal damage with changes in the electrophysiological properties of voltage-gated sodium and potassium channels. Molecular Brain. 14: 124. PMID 34384467 DOI: 10.1186/s13041-021-00837-z   
2021 Byers N, Hahm ET, Tsunoda S. Slo2/K Channels in Protect Against Spontaneous and Induced Seizure-like Behavior Associated with an Increased Persistent Na Current. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34544836 DOI: 10.1523/JNEUROSCI.0290-21.2021   
2021 Isensee J, van Cann M, Despang P, Araldi D, Moeller K, Petersen J, Schmidtko A, Matthes J, Levine JD, Hucho T. Depolarization induces nociceptor sensitization by CaV1.2-mediated PKA-II activation. The Journal of Cell Biology. 220. PMID 34431981 DOI: 10.1083/jcb.202002083   
2021 Hu Y, Li Q, Shen Y, Fujita T, Zhu X, Inoue R. Theoretical Investigation of the Mechanism by which A Gain-of-Function Mutation of the TRPM4 Channel Causes Conduction Block. International Journal of Molecular Sciences. 22. PMID 34445219 DOI: 10.3390/ijms22168513   
2021 Spratt PWE, Alexander RPD, Ben-Shalom R, Sahagun A, Kyoung H, Keeshen CM, Sanders SJ, Bender KJ. Paradoxical hyperexcitability from Na1.2 sodium channel loss in neocortical pyramidal cells. Cell Reports. 36: 109483. PMID 34348157 DOI: 10.1016/j.celrep.2021.109483   
2021 Nakamura M, Jang IS. Propranolol modulation of tetrodotoxin-resistant Na channels in dural afferent neurons. European Journal of Pharmacology. 910: 174449. PMID 34454925 DOI: 10.1016/j.ejphar.2021.174449   
2021 Wu XY, Lv JY, Zhang SQ, Yi X, Xu ZW, Zhi YX, Zhao BX, Pang JX, Yung KKL, Liu SW, Zhou PZ. ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome. Acta Pharmacologica Sinica. PMID 34341510 DOI: 10.1038/s41401-021-00739-9   
2021 Li Y, Aziz Q, Tinker A. The Pharmacology of ATP-Sensitive K Channels (K). Handbook of Experimental Pharmacology. PMID 34247283 DOI: 10.1007/164_2021_466   
2021 Ramkumar V, Sheth S, Dhukhwa A, Al Aameri R, Rybak LP, Mukherjea D. Transient Receptor Potential (TRP) Channels and Auditory Functions. Antioxidants & Redox Signaling. PMID 34465184 DOI: 10.1089/ars.2021.0191   
2021 Beurg M, Nam JH, Fettiplace R. The speed of the hair cell mechanotransducer channel revealed by fluctuation analysis. The Journal of General Physiology. 153. PMID 34411238 DOI: 10.1085/jgp.202112959   
2021 Recugnat M, Undurraga JA, Mcalpine D. Spike-rate adaptation in a computational model of human-shaped spiral ganglion neurons. Ieee Transactions On Bio-Medical Engineering. PMID 34347592 DOI: 10.1109/TBME.2021.3102129   
2021 Lengyel M, Enyedi P, Czirják G. Negative Influence by the Force: Mechanically Induced Hyperpolarization via K Background Potassium Channels. International Journal of Molecular Sciences. 22. PMID 34445768 DOI: 10.3390/ijms22169062   
2021 Hung A, Forster IC, Mckenzie CE, Berecki G, Petrou S, Kathirvel A, Soh MS, Reid CA. Biophysical analysis of an HCN1 epilepsy variant suggests a critical role for S5 helix Met-305 in voltage sensor to pore domain coupling. Progress in Biophysics and Molecular Biology. PMID 34298002 DOI: 10.1016/j.pbiomolbio.2021.07.005   
2021 Hung A, Forster IC, Mckenzie CE, Berecki G, Petrou S, Kathirvel A, Soh MS, Reid CA. Biophysical analysis of an HCN1 epilepsy variant suggests a critical role for S5 helix Met-305 in voltage sensor to pore domain coupling. Progress in Biophysics and Molecular Biology. PMID 34298002 DOI: 10.1016/j.pbiomolbio.2021.07.005   
2021 Napolitano LMR, Torre V, Marchesi A. CNG channel structure, function, and gating: a tale of conformational flexibility. Pflugers Archiv : European Journal of Physiology. 473: 1423-1435. PMID 34357442 DOI: 10.1007/s00424-021-02610-6   
2021 Ali Shah SM, Ou YY. TRP-BERT: Discrimination of transient receptor potential (TRP) channels using contextual representations from deep bidirectional transformer based on BERT. Computers in Biology and Medicine. 137: 104821. PMID 34508974 DOI: 10.1016/j.compbiomed.2021.104821   
2021 Caldwell JH. Membrane excitability: Ankyrins keep neuromuscular junctions firing. Current Biology : Cb. 31: R1061-R1063. PMID 34520721 DOI: 10.1016/j.cub.2021.07.042   
2021 Park KM, Kim SD, Park JB, Hong SJ, Ryu PD. Electrophysiological Properties of Ion Channels in Ascaris suum Tissue Incorporated into Planar Lipid Bilayers. The Korean Journal of Parasitology. 59: 329-339. PMID 34470084 DOI: 10.3347/kjp.2021.59.4.329   
2021 Rivera B, Moreno C, Lavanderos B, Hwang JY, Fernández-Trillo J, Park KS, Orio P, Viana F, Madrid R, Pertusa M. Constitutive phosphorylation as a key regulator of TRPM8 channel function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34446569 DOI: 10.1523/JNEUROSCI.0345-21.2021   
2021 Anderson A, Vo BN, Marron Fernandez de Velasco E, Hopkins CR, Weaver CD, Wickman K. . Molecular Pharmacology. PMID 34503975 DOI: 10.1124/molpharm.121.000311   
2021 He Y, Lin Y, He F, Shao L, Ma W, He F. Role for calcium-activated potassium channels (BK) in migration control of human hepatocellular carcinoma cells. Journal of Cellular and Molecular Medicine. PMID 34514691 DOI: 10.1111/jcmm.16918   
2021 Wang M, Sun Y, Li L, Wu P, Dkw O, Shi H. Calcium Channels: Noteworthy Regulators and Therapeutic Targets in Dermatological Diseases. Frontiers in Pharmacology. 12: 702264. PMID 34489697 DOI: 10.3389/fphar.2021.702264   
2021 Monteiro O, Bhaskar A, Wong IN, Ng AKM, Baptista-Hon DT. Teaching bioelectricity and neurophysiology to medical students using LabAXON simulations. Advances in Physiology Education. 45: 702-708. PMID 34498935 DOI: 10.1152/advan.00054.2021   
2021 Qian LL, Sun X, Yang J, Wang XL, Ackerman MJ, Wang RX, Xu X, Lee HC, Lu T. Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 166247. PMID 34487812 DOI: 10.1016/j.bbadis.2021.166247   
2021 Emam AM, Peigneur S, Depuydt AS, Ibrahim SM, Lopes Pinheiro-Junior E, El-Sadek M, Hendrickx L, Tytgat J, Kothayer H. Quinazolinone dimers as a potential new class of safer Kv1 inhibitors: Overcoming hERG, sodium and calcium channel affinities. Bioorganic Chemistry. 115: 105264. PMID 34416509 DOI: 10.1016/j.bioorg.2021.105264   
2021 Catacuzzeno L, Franciolini F, Bezanilla F, Eisenberg RS. Gating current noise produced by Brownian models of a voltage sensor. Biophysical Journal. PMID 34411574 DOI: 10.1016/j.bpj.2021.08.015   
2021 Wu X, Ramentol R, Perez ME, Noskov SY, Larsson HP. A second S4 movement opens hyperpolarization-activated HCN channels. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34504015 DOI: 10.1073/pnas.2102036118   
2021 Amberg GC, Lee JY, Don Koh S, Sanders KM. Characterization of the A-Type potassium current in murine gastric fundus smooth muscles. American Journal of Physiology. Cell Physiology. PMID 34432539 DOI: 10.1152/ajpcell.00247.2021   
2021 Hawn MB, Akin E, Hartzell HC, Greenwood IA, Leblanc N. Molecular Mechanisms of Activation and Regulation of ANO1-Encoded Ca2+-Activated Cl- Channels. Channels (Austin, Tex.). PMID 34488544 DOI: 10.1080/19336950.2021.1975411   
2021 Tanwar M, Kateriya S, Nair D, Jose M. Optogenetic modulation of real-time nanoscale dynamics of HCN channels using photoactivated adenylyl cyclases. Rsc Chemical Biology. 2: 863-875. PMID 34458814 DOI: 10.1039/d0cb00124d   
2021 Gomez K, Vargas-Parada A, Duran P, Sandoval A, Delgado-Lezama R, Khanna R, Felix R. L5-6 spinal nerve ligation-induced neuropathy changes the location and function of Ca channels and Cdk5 and affects the compound action potential in adjacent intact L4 afferent fibers. Neuroscience. PMID 34303780 DOI: 10.1016/j.neuroscience.2021.07.013   
2021 Bowley KA, Sandle GI. Calmodulin Antagonist W-7 Enhances Intermediate Conductance Ca- Sensitive Basolateral Potassium Channel (IK) Activity in Human Colonic Crypts. The Journal of Membrane Biology. PMID 34313792 DOI: 10.1007/s00232-021-00193-y   
2021 Zhou M, Du Y, Aten S, Terman D. On the electrical passivity of astrocyte potassium conductance. Journal of Neurophysiology. PMID 34525325 DOI: 10.1152/jn.00330.2021   
2021 El Ghaleb Y, Fernández-Quintero ML, Monteleone S, Tuluc P, Campiglio M, Liedl KR, Flucher BE. Ion-pair interactions between voltage-sensing domain IV and pore domain I regulate Ca1.1 channel gating. Biophysical Journal. PMID 34506774 DOI: 10.1016/j.bpj.2021.09.004   
2021 Huang X, Liu C, Zeng S, Tang Z, Wang S, Chen X, Zhang DW, Zhou P. Ultrathin Multibridge Channel Transistor Enabled by van der Waals Assembly. Advanced Materials (Deerfield Beach, Fla.). e2102201. PMID 34337802 DOI: 10.1002/adma.202102201   
2021 Asadi M, Ayat H, Ahadi AM, Ranjbar MS. Genomic Structure of Two Kv1.3 Channel Blockers from Scorpion Mesobuthus eupeus and Sea Anemone Stichodactyla haddoni and Construction of their Chimeric Peptide as a Novel Blocker. Biochemical Genetics. PMID 34286408 DOI: 10.1007/s10528-021-10109-z   
2021 Luo Y, Huang L, Liao P, Jiang R. Contribution of Neuronal and Glial Two-Pore-Domain Potassium Channels in Health and Neurological Disorders. Neural Plasticity. 2021: 8643129. PMID 34434230 DOI: 10.1155/2021/8643129   
2021 Ganguly S, Thompson CH, George AL. Enhanced slow inactivation contributes to dysfunction of a recurrent SCN2A mutation associated with developmental and epileptic encephalopathy. The Journal of Physiology. PMID 34287911 DOI: 10.1113/JP281834   
2021 Ganguly S, Thompson CH, George AL. Enhanced slow inactivation contributes to dysfunction of a recurrent SCN2A mutation associated with developmental and epileptic encephalopathy. The Journal of Physiology. PMID 34287911 DOI: 10.1113/JP281834   
2021 Rietmeijer RA, Sorum B, Li B, Brohawn SG. Physical basis for distinct basal and mechanically gated activity of the human K channel TRAAK. Neuron. PMID 34390650 DOI: 10.1016/j.neuron.2021.07.009   
2021 Canales Coutiño B, Mayor R. Reprint of: Mechanosensitive ion channels in cell migration. Cells & Development. 203730. PMID 34456177 DOI: 10.1016/j.cdev.2021.203730   
2021 Ke W, Yu X, Gao Y. Neonatal exposure to sevoflurane caused learning and memory impairment via dysregulating SK2 channel endocytosis. Science Progress. 104: 368504211043763. PMID 34533073 DOI: 10.1177/00368504211043763   
2021 Verkest C, Diochot S, Lingueglia E, Baron A. C-Jun N-terminal kinase post-translational regulation of pain-related Acid-Sensing Ion Channels 1b and 3. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34380759 DOI: 10.1523/JNEUROSCI.0570-21.2021   
2021 Qauli AI, Marcellinus A, Lim KM. Sensitivity Analysis of Ion Channel Conductance on Myocardial Electromechanical Delay: Computational Study. Frontiers in Physiology. 12: 697693. PMID 34512377 DOI: 10.3389/fphys.2021.697693   
2021 Kodirov SA, Brachmann J, Safonova TA, Zhuravlev VL. Inactivation of Native K Channels. The Journal of Membrane Biology. PMID 34383081 DOI: 10.1007/s00232-021-00195-w   
2021 Choi SW, Yin MZ, Park NK, Woo JH, Kim SJ. Dual Mechanisms of Cardiac Action Potential Prolongation by 4-Oxo-Nonenal Increasing the Risk of Arrhythmia; Late Na Current Induction and hERG K Channel Inhibition. Antioxidants (Basel, Switzerland). 10. PMID 34356372 DOI: 10.3390/antiox10071139   
2021 Jacobsson E, Peigneur S, Andersson HS, Laborde Q, Strand M, Tytgat J, Göransson U. Functional Characterization of the Nemertide α Family of Peptide Toxins. Journal of Natural Products. 84: 2121-2128. PMID 34445875 DOI: 10.1021/acs.jnatprod.1c00104   
2021 Vouga AG, Rockman ME, Yan J, Jacobson MA, Rothberg BS. State-dependent inhibition of BK channels by the opioid agonist loperamide. The Journal of General Physiology. 153. PMID 34357374 DOI: 10.1085/jgp.202012834