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Frank Longo - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Latif-Hernandez A, Yang T, Raymond-Butler R, Losada PM, Minhas P, White H, Tran KC, Liu H, Simmons DA, Langness V, Andreasson K, Wyss-Coray T, Longo FM. A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model. Biorxiv : the Preprint Server For Biology. PMID 37781573 DOI: 10.1101/2023.09.18.558138  0.536
2023 Simmons DA, Belichenko NP, Longo FM. Pharmacological Co-Activation of TrkB and TrkC Receptor Signaling Ameliorates Striatal Neuropathology and Motor Deficits in Mouse Models of Huntington's Disease. Journal of Huntington's Disease. PMID 37638447 DOI: 10.3233/JHD-230589  0.578
2021 Gonzalez S, McHugh TLM, Yang T, Syriani W, Massa SM, Longo FM, Simmons DA. Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological stage. Neurobiology of Disease. 105563. PMID 34838668 DOI: 10.1016/j.nbd.2021.105563  0.607
2021 Simmons DA, Mills BD, Butler Iii RR, Kuan J, McHugh TLM, Akers C, Zhou J, Syriani W, Grouban M, Zeineh M, Longo FM. Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75 Ligand LM11A-31. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33786806 DOI: 10.1007/s13311-021-01023-8  0.533
2019 Mufson EJ, Counts SE, Ginsberg SD, Mahady L, Perez SE, Massa SM, Longo FM, Ikonomovic MD. Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease. Frontiers in Neuroscience. 13: 533. PMID 31312116 DOI: 10.3389/fnins.2019.00533  0.314
2019 Simmons DA, Lartey FM, Schüler E, Rafat M, King G, Kim A, Ko R, Semaan S, Gonzalez S, Jenkins M, Pradhan P, Shih Z, Wang J, von Eyben R, Graves EE, ... ... Longo FM, et al. Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. PMID 31253467 DOI: 10.1016/J.Radonc.2019.06.006  0.498
2019 Boakye PA, Rancic V, Whitlock KH, Simmons D, Longo FM, Ballanyi K, Smith PA. Receptor-dependence of BDNF Actions in Superficial Dorsal Horn; Relation to Central Sensitization and Actions of Macrophage Colony Stimulating Factor 1 (CSF-1). Journal of Neurophysiology. PMID 30995156 DOI: 10.1152/Jn.00839.2018  0.604
2018 Simmons DA, James ML, Belichenko NP, Semaan S, Condon C, Kuan J, Shuhendler AJ, Miao Z, Chin FT, Longo FM. TSPO-PET Imaging Using [18F]PBR06 is a Potential Translatable Biomarker for Treatment Response in Huntington's Disease: Preclinical Evidence with the p75NTR Ligand LM11A-31. Human Molecular Genetics. PMID 29860333 DOI: 10.1093/Hmg/Ddy202  0.514
2016 Simmons DA, Belichenko NP, Ford EC, Semaan S, Monbureau M, Aiyaswamy S, Holman CM, Condon C, Shamloo M, Massa SM, Longo FM. A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice. Human Molecular Genetics. 25: 4920-4938. PMID 28171570 DOI: 10.1093/Hmg/Ddw316  0.572
2016 Simmons DA, Longo FM, Massa SM. Neurotrophin receptor signaling as a therapeutic target for Huntington's Disease. Cns & Neurological Disorders Drug Targets. PMID 27823570 DOI: 10.2174/1871527315666161107093047  0.551
2016 Simmons DA, Belichenko NP, Ford EC, Semaan S, Monbureau M, Aiyaswamy S, Holman CM, Condon C, Shamloo M, Massa SM, Longo FM. A small molecule p75NTR ligand normalizes signaling and reduces Huntington's Disease phenotypes in R6/2 and BACHD mice. Human Molecular Genetics. PMID 27638888 DOI: 10.1093/hmg/ddw316  0.575
2016 Yang T, Massa SM, Tran KC, Simmons DA, Rajadas J, Zeng AY, Jang T, Carsanaro S, Longo FM. A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology. PMID 27334657 DOI: 10.1016/J.Neuropharm.2016.06.015  0.703
2015 Malkovskiy AV, Wagh DA, Longo FM, Rajadas J. A strategy for analyzing bond strength and interaction kinetics between Pleckstrin homology domains and PI(4,5)P2 phospholipids using force distance spectroscopy and surface plasmon resonance. The Analyst. 140: 4558-65. PMID 26040325 DOI: 10.1039/C5An00498E  0.484
2014 Friesland A, Weng Z, Duenas M, Massa SM, Longo FM, Lu Q. Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75 NTR. Neurotoxicology. 45: 81-90. PMID 25277379 DOI: 10.1016/j.neuro.2014.09.005  0.3
2014 Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. Plos One. 9: e102136. PMID 25153701 DOI: 10.1371/journal.pone.0102136  0.566
2014 Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, ... ... Longo FM, et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine. 20: 659-63. PMID 24793238 DOI: 10.1038/Nm.3569  0.499
2013 Simmons DA, Belichenko NP, Yang T, Condon C, Monbureau M, Shamloo M, Jing D, Massa SM, Longo FM. A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 18712-27. PMID 24285878 DOI: 10.1523/Jneurosci.1310-13.2013  0.59
2013 Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM. Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model. Neurobiology of Aging. 34: 2052-63. PMID 23545424 DOI: 10.1016/J.Neurobiolaging.2013.02.015  0.584
2013 Longo F, Nguyen T, Simmons D, Yang T, Knowles J, Zhang H, Arancio O, Massa S, Longo F. S4-02-04: Targeting Alzheimer's disease-related mechanisms with p75 ligands Alzheimer's & Dementia. 9: P674-P674. DOI: 10.1016/J.Jalz.2013.04.323  0.559
2010 Massa SM, Yang T, Xie Y, Shi J, Bilgen M, Joyce JN, Nehama D, Rajadas J, Longo FM. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. The Journal of Clinical Investigation. 120: 1774-85. PMID 20407211 DOI: 10.1172/Jci41356  0.593
2009 Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM. The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10627-37. PMID 19710315 DOI: 10.1523/Jneurosci.0620-09.2009  0.552
2008 Yang T, Knowles JK, Lu Q, Zhang H, Arancio O, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller GG, Xie Y, Massa SM, Longo FM. Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment. Plos One. 3: e3604. PMID 18978948 DOI: 10.1371/Journal.Pone.0003604  0.57
1997 Longo FM, Manthorpe M, Xie YM, Varon S. Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism. Journal of Neuroscience Research. 48: 1-17. PMID 9086177 DOI: 10.1002/(Sici)1097-4547(19970401)48:1<1::Aid-Jnr1>3.0.Co;2-K  0.656
1989 Fields RD, Le Beau JM, Longo FM, Ellisman MH. Nerve regeneration through artificial tubular implants. Progress in Neurobiology. 33: 87-134. PMID 2678271 DOI: 10.1016/0301-0082(89)90036-1  0.588
1984 Longo FM, Selak I, Zovickian J, Manthorpe M, Varon S, U HS. Neuronotrophic activities in cerebrospinal fluid of head trauma patients. Experimental Neurology. 84: 207-18. PMID 6705885 DOI: 10.1016/0014-4886(84)90016-5  0.669
1984 Longo FM, Hayman EG, Davis GE, Ruoslahti E, Engvall E, Manthorpe M, Varon S. Neurite-promoting factors and extracellular matrix components accumulating in vivo within nerve regeneration chambers. Brain Research. 309: 105-17. PMID 6488001 DOI: 10.1016/0006-8993(84)91014-X  0.676
1983 Longo FM, Skaper SD, Manthorpe M, Williams LR, Lundborg G, Varon S. Temporal changes of neuronotrophic activities accumulating in vivo within nerve regeneration chambers. Experimental Neurology. 81: 756-69. PMID 6884483 DOI: 10.1016/0014-4886(83)90342-4  0.668
1983 Manthorpe M, Luyten W, Longo FM, Varon S. Endogenous and exogenous factors support neuronal survival and choline acetyltransferase activity in embryonic spinal cord cultures. Brain Research. 267: 57-66. PMID 6860950 DOI: 10.1016/0006-8993(83)91039-9  0.665
1983 Longo FM, Manthorpe M, Skaper SD, Lundborg G, Varon S. Neuronotrophic activities accumulate in vivo within silicone nerve regeneration chambers. Brain Research. 261: 109-16. PMID 6839146 DOI: 10.1016/0006-8993(83)91289-1  0.653
1983 Manthorpe M, Engvall E, Ruoslahti E, Longo FM, Davis GE, Varon S. Laminin promotes neuritic regeneration from cultured peripheral and central neurons. The Journal of Cell Biology. 97: 1882-90. PMID 6643580 DOI: 10.1083/Jcb.97.6.1882  0.689
1983 Williams LR, Longo FM, Powell HC, Lundborg G, Varon S. Spatial-temporal progress of peripheral nerve regeneration within a silicone chamber: parameters for a bioassay. The Journal of Comparative Neurology. 218: 460-70. PMID 6619324 DOI: 10.1002/Cne.902180409  0.48
1982 Lundborg G, Dahlin LB, Danielsen N, Hansson HA, Johannesson A, Longo FM, Varon S. Nerve regeneration across an extended gap: a neurobiological view of nerve repair and the possible involvement of neuronotrophic factors. The Journal of Hand Surgery. 7: 580-7. PMID 7175129 DOI: 10.1016/S0363-5023(82)80107-X  0.495
1982 Manthorpe M, Longo FM, Varon S. Comparative features of spinal neuronotrophic factors in fluids collected in vitro and in vivo. Journal of Neuroscience Research. 8: 241-50. PMID 7154113 DOI: 10.1002/Jnr.490080214  0.66
1982 Nieto-Sampedro M, Lewis ER, Cotman CW, Manthorpe M, Skaper SD, Barbin G, Longo FM, Varon S. Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site. Science (New York, N.Y.). 217: 860-1. PMID 7100931 DOI: 10.1126/Science.7100931  0.667
1982 Lundborg G, Gelberman RH, Longo FM, Powell HC, Varon S. In vivo regeneration of cut nerves encased in silicone tubes: growth across a six-millimeter gap. Journal of Neuropathology and Experimental Neurology. 41: 412-22. PMID 7086464 DOI: 10.1097/00005072-198207000-00004  0.494
1982 Longo FM, Manthorpe M, Varon S. Spinal cord neuronotrophic factors (SCNTFs): I. Bioassay of schwannoma and other conditioned media. Brain Research. 255: 277-94. PMID 7055725 DOI: 10.1016/0165-3806(82)90027-X  0.672
1982 Lundborg G, Longo FM, Varon S. Nerve regeneration model and trophic factors in vivo. Brain Research. 232: 157-61. PMID 7055692 DOI: 10.1016/0006-8993(82)90618-7  0.541
1982 Longo FM, Lundborg G, Varon S, Powell HC. NERVE REGENERATION IN SILICONE CHAMBERS Journal of Neuropathology and Experimental Neurology. 41: 372. DOI: 10.1097/00005072-198205000-00103  0.47
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