Steven A. Siegelbaum - Publications

Columbia University, New York, NY 

144 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Russo MJ, Franks KM, Oghaz R, Axel R, Siegelbaum SA. Synaptic organization of anterior olfactory nucleus inputs to piriform cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33115926 DOI: 10.1523/JNEUROSCI.0965-20.2020  0.72
2020 Donegan ML, Stefanini F, Meira T, Gordon JA, Fusi S, Siegelbaum SA. Coding of social novelty in the hippocampal CA2 region and its disruption and rescue in a 22q11.2 microdeletion mouse model. Nature Neuroscience. 23: 1365-1375. PMID 33077947 DOI: 10.1038/s41593-020-00720-5  0.76
2020 Oliva A, Fernández-Ruiz A, Leroy F, Siegelbaum SA. Hippocampal CA2 sharp-wave ripples reactivate and promote social memory. Nature. PMID 32968277 DOI: 10.1038/s41586-020-2758-y  0.76
2020 Masurkar AV, Tian C, Warren R, Reyes I, Lowes DC, Brann DH, Siegelbaum SA. Postsynaptic integrative properties of dorsal CA1 pyramidal neuron subpopulations. Journal of Neurophysiology. PMID 31967926 DOI: 10.1152/jn.00397.2019  0.76
2019 Leroy F, Brann DH, Meira T, Siegelbaum SA. Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory. Neuron. 102: 260-262. PMID 30946821 DOI: 10.1016/j.neuron.2019.03.021  0.76
2018 Leroy F, Park J, Asok A, Brann DH, Meira T, Boyle LM, Buss EW, Kandel ER, Siegelbaum SA. A circuit from hippocampal CA2 to lateral septum disinhibits social aggression. Nature. PMID 30518859 DOI: 10.1038/s41586-018-0772-0  1
2018 Meira T, Leroy F, Buss EW, Oliva A, Park J, Siegelbaum SA. A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics. Nature Communications. 9: 4163. PMID 30301899 DOI: 10.1038/s41467-018-06501-w  0.76
2018 Teixeira CM, Rosen ZB, Suri D, Sun Q, Hersh M, Sargin D, Dincheva I, Morgan AA, Spivack S, Krok AC, Hirschfeld-Stoler T, Lambe EK, Siegelbaum SA, Ansorge MS. Hippocampal 5-HT Input Regulates Memory Formation and Schaffer Collateral Excitation. Neuron. PMID 29754752 DOI: 10.1016/j.neuron.2018.04.030  0.6
2017 Leroy F, Brann DH, Meira T, Siegelbaum SA. Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory. Neuron. PMID 28823730 DOI: 10.1016/j.neuron.2017.07.036  0.76
2017 Sun Q, Sotayo A, Cazzulino AS, Snyder AM, Denny CA, Siegelbaum SA. Proximodistal Heterogeneity of Hippocampal CA3 Pyramidal Neuron Intrinsic Properties, Connectivity, and Reactivation during Memory Recall. Neuron. 95: 656-672.e3. PMID 28772124 DOI: 10.1016/j.neuron.2017.07.012  0.56
2017 Srinivas KV, Buss EW, Sun Q, Santoro B, Takahashi H, Nicholson DA, Siegelbaum SA. The dendrites of CA2 and CA1 pyramidal neurons differentially regulate information flow in the cortico-hippocampal circuit. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28213444 DOI: 10.1523/JNEUROSCI.2219-16.2017  0.76
2017 Masurkar AV, Srinivas KV, Brann DH, Warren R, Lowes DC, Siegelbaum SA. Medial and Lateral Entorhinal Cortex Differentially Excite Deep versus Superficial CA1 Pyramidal Neurons. Cell Reports. 18: 148-160. PMID 28052245 DOI: 10.1016/j.celrep.2016.12.012  0.76
2016 Piskorowski RA, Nasrallah K, Diamantopoulou A, Mukai J, Hassan SI, Siegelbaum SA, Gogos JA, Chevaleyre V. Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome. Neuron. 89: 163-176. PMID 26748091 DOI: 10.1016/j.neuron.2015.11.036  1
2016 Basu J, Zaremba JD, Cheung SK, Hitti FL, Zemelman BV, Losonczy A, Siegelbaum SA. Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition. Science (New York, N.Y.). 351: aaa5694. PMID 26744409 DOI: 10.1126/science.aaa5694  1
2015 Basu J, Siegelbaum SA. The Corticohippocampal Circuit, Synaptic Plasticity, and Memory. Cold Spring Harbor Perspectives in Biology. 7. PMID 26525152 DOI: 10.1101/cshperspect.a021733  1
2015 Rosen ZB, Cheung S, Siegelbaum SA. Midbrain dopamine neurons bidirectionally regulate CA3-CA1 synaptic drive. Nature Neuroscience. PMID 26523642 DOI: 10.1038/nn.4152  1
2014 Sun Q, Srinivas KV, Sotayo A, Siegelbaum SA. Dendritic Na(+) spikes enable cortical input to drive action potential output from hippocampal CA2 pyramidal neurons. Elife. 3. PMID 25390033 DOI: 10.7554/eLife.04551  1
2014 Lei YT, Thuault SJ, Launay P, Margolskee RF, Kandel ER, Siegelbaum SA. Differential contribution of TRPM4 and TRPM5 nonselective cation channels to the slow afterdepolarization in mouse prefrontal cortex neurons. Frontiers in Cellular Neuroscience. 8: 267. PMID 25237295 DOI: 10.3389/fncel.2014.00267  1
2014 Kupferman JV, Basu J, Russo MJ, Guevarra J, Cheung SK, Siegelbaum SA. Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment. Cell. 158: 1335-47. PMID 25201528 DOI: 10.1016/j.cell.2014.07.035  1
2014 Hitti FL, Siegelbaum SA. The hippocampal CA2 region is essential for social memory. Nature. 508: 88-92. PMID 24572357 DOI: 10.1038/nature13028  1
2013 Hu L, Santoro B, Saponaro A, Liu H, Moroni A, Siegelbaum S. Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP. The Journal of General Physiology. 142: 599-612. PMID 24277603 DOI: 10.1085/jgp.201311013  1
2013 Basu J, Srinivas KV, Cheung SK, Taniguchi H, Huang ZJ, Siegelbaum SA. A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow. Neuron. 79: 1208-21. PMID 24050406 DOI: 10.1016/j.neuron.2013.07.001  0.56
2013 Thuault SJ, Malleret G, Constantinople CM, Nicholls R, Chen I, Zhu J, Panteleyev A, Vronskaya S, Nolan MF, Bruno R, Siegelbaum SA, Kandel ER. Prefrontal cortex HCN1 channels enable intrinsic persistent neural firing and executive memory function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 13583-99. PMID 23966682 DOI: 10.1523/JNEUROSCI.2427-12.2013  1
2012 Mayford M, Siegelbaum SA, Kandel ER. Synapses and memory storage. Cold Spring Harbor Perspectives in Biology. 4. PMID 22496389 DOI: 10.1101/cshperspect.a005751  1
2011 Hussaini SA, Kempadoo KA, Thuault SJ, Siegelbaum SA, Kandel ER. Increased size and stability of CA1 and CA3 place fields in HCN1 knockout mice. Neuron. 72: 643-53. PMID 22099465 DOI: 10.1016/j.neuron.2011.09.007  1
2011 Franks KM, Russo MJ, Sosulski DL, Mulligan AA, Siegelbaum SA, Axel R. Recurrent circuitry dynamically shapes the activation of piriform cortex. Neuron. 72: 49-56. PMID 21982368 DOI: 10.1016/j.neuron.2011.08.020  1
2011 Piskorowski R, Santoro B, Siegelbaum SA. TRIP8b splice forms act in concert to regulate the localization and expression of HCN1 channels in CA1 pyramidal neurons. Neuron. 70: 495-509. PMID 21555075 DOI: 10.1016/j.neuron.2011.03.023  1
2011 Santoro B, Hu L, Liu H, Saponaro A, Pian P, Piskorowski RA, Moroni A, Siegelbaum SA. TRIP8b regulates HCN1 channel trafficking and gating through two distinct C-terminal interaction sites. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4074-86. PMID 21411649 DOI: 10.1523/JNEUROSCI.5707-10.2011  1
2010 Chen YH, Hu L, Punta M, Bruni R, Hillerich B, Kloss B, Rost B, Love J, Siegelbaum SA, Hendrickson WA. Homologue structure of the SLAC1 anion channel for closing stomata in leaves. Nature. 467: 1074-80. PMID 20981093 DOI: 10.1038/nature09487  1
2010 Chevaleyre V, Siegelbaum SA. Strong CA2 pyramidal neuron synapses define a powerful disynaptic cortico-hippocampal loop. Neuron. 66: 560-72. PMID 20510860 DOI: 10.1016/j.neuron.2010.04.013  1
2010 Santoro B, Lee JY, Englot DJ, Gildersleeve S, Piskorowski RA, Siegelbaum SA, Winawer MR, Blumenfeld H. Increased seizure severity and seizure-related death in mice lacking HCN1 channels. Epilepsia. 51: 1624-7. PMID 20384728 DOI: 10.1111/j.1528-1167.2010.02554.x  1
2010 DeCostanzo AJ, Voloshyna I, Rosen ZB, Feinmark SJ, Siegelbaum SA. 12-Lipoxygenase regulates hippocampal long-term potentiation by modulating L-type Ca2+ channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 1822-31. PMID 20130191 DOI: 10.1523/JNEUROSCI.2168-09.2010  1
2009 Ahmed MS, Siegelbaum SA. Recruitment of N-Type Ca(2+) channels during LTP enhances low release efficacy of hippocampal CA1 perforant path synapses. Neuron. 63: 372-85. PMID 19679076 DOI: 10.1016/j.neuron.2009.07.013  1
2009 Santoro B, Piskorowski RA, Pian P, Hu L, Liu H, Siegelbaum SA. TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain. Neuron. 62: 802-13. PMID 19555649 DOI: 10.1016/j.neuron.2009.05.009  1
2009 George MS, Abbott LF, Siegelbaum SA. HCN hyperpolarization-activated cation channels inhibit EPSPs by interactions with M-type K(+) channels. Nature Neuroscience. 12: 577-84. PMID 19363490 DOI: 10.1038/nn.2307  1
2009 Bell DC, Turbendian HK, Valley MT, Zhou L, Riley JH, Siegelbaum SA, Tibbs GR. Probing S4 and S5 segment proximity in mammalian hyperpolarization-activated HCN channels by disulfide bridging and Cd2+ coordination. PflüGers Archiv : European Journal of Physiology. 458: 259-72. PMID 19034494 DOI: 10.1007/s00424-008-0613-3  1
2008 Zhou L, Siegelbaum SA. Pathway and endpoint free energy calculations for cyclic nucleotide binding to HCN channels. Biophysical Journal. 94: L90-2. PMID 18408037 DOI: 10.1529/biophysj.108.130872  1
2008 Zhou L, Siegelbaum SA. Effects of surface water on protein dynamics studied by a novel coarse-grained normal mode approach. Biophysical Journal. 94: 3461-74. PMID 18212016 DOI: 10.1529/biophysj.107.115956  1
2007 Tsay D, Dudman JT, Siegelbaum SA. HCN1 channels constrain synaptically evoked Ca2+ spikes in distal dendrites of CA1 pyramidal neurons. Neuron. 56: 1076-89. PMID 18093528 DOI: 10.1016/j.neuron.2007.11.015  1
2007 Dudman JT, Tsay D, Siegelbaum SA. A role for synaptic inputs at distal dendrites: instructive signals for hippocampal long-term plasticity. Neuron. 56: 866-79. PMID 18054862 DOI: 10.1016/j.neuron.2007.10.020  1
2007 Pian P, Bucchi A, Decostanzo A, Robinson RB, Siegelbaum SA. Modulation of cyclic nucleotide-regulated HCN channels by PIP(2) and receptors coupled to phospholipase C. PflüGers Archiv : European Journal of Physiology. 455: 125-45. PMID 17605039 DOI: 10.1007/s00424-007-0295-2  1
2007 Zhou L, Siegelbaum SA. Gating of HCN channels by cyclic nucleotides: residue contacts that underlie ligand binding, selectivity, and efficacy. Structure (London, England : 1993). 15: 655-70. PMID 17562313 DOI: 10.1016/j.str.2007.04.012  1
2007 Chen S, Wang J, Zhou L, George MS, Siegelbaum SA. Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels. The Journal of General Physiology. 129: 175-88. PMID 17261842 DOI: 10.1085/jgp.200609585  1
2006 Pian P, Bucchi A, Robinson RB, Siegelbaum SA. Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2. The Journal of General Physiology. 128: 593-604. PMID 17074978 DOI: 10.1085/jgp.200609648  1
2006 Dudman JT, Siegelbaum SA. Making the grade with models of persistent activity. Neuron. 49: 649-51. PMID 16504940 DOI: 10.1016/j.neuron.2006.02.010  1
2005 Paterlini M, Zakharenko SS, Lai WS, Qin J, Zhang H, Mukai J, Westphal KG, Olivier B, Sulzer D, Pavlidis P, Siegelbaum SA, Karayiorgou M, Gogos JA. Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice. Nature Neuroscience. 8: 1586-94. PMID 16234811 DOI: 10.1038/nn1562  1
2005 Huang YY, Zakharenko SS, Schoch S, Kaeser PS, Janz R, Südhof TC, Siegelbaum SA, Kandel ER. Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation. Proceedings of the National Academy of Sciences of the United States of America. 102: 9365-70. PMID 15967982 DOI: 10.1073/pnas.0503777102  1
2005 Jan LY, Siegelbaum SA. Signaling mechanisms Current Opinion in Neurobiology. 15: 253-256. DOI: 10.1016/j.conb.2005.05.015  1
2004 Zhou L, Olivier NB, Yao H, Young EC, Siegelbaum SA. A conserved tripeptide in CNG and HCN channels regulates ligand gating by controlling C-terminal oligomerization. Neuron. 44: 823-34. PMID 15572113 DOI: 10.1016/j.neuron.2004.11.012  1
2004 Santoro B, Wainger BJ, Siegelbaum SA. Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10750-62. PMID 15564593 DOI: 10.1523/JNEUROSCI.3300-04.2004  1
2004 Nolan MF, Malleret G, Dudman JT, Buhl DL, Santoro B, Gibbs E, Vronskaya S, Buzsáki G, Siegelbaum SA, Kandel ER, Morozov A. A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons. Cell. 119: 719-32. PMID 15550252 DOI: 10.1016/j.cell.2004.11.020  1
2004 Lang C, Barco A, Zablow L, Kandel ER, Siegelbaum SA, Zakharenko SS. Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiation. Proceedings of the National Academy of Sciences of the United States of America. 101: 16665-70. PMID 15542587 DOI: 10.1073/pnas.0407581101  1
2004 Unni VK, Zakharenko SS, Zablow L, DeCostanzo AJ, Siegelbaum SA. Calcium release from presynaptic ryanodine-sensitive stores is required for long-term depression at hippocampal CA3-CA3 pyramidal neuron synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 9612-22. PMID 15509748 DOI: 10.1523/JNEUROSCI.5583-03.2004  1
2004 Bell DC, Yao H, Saenger RC, Riley JH, Siegelbaum SA. Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels. The Journal of General Physiology. 123: 5-19. PMID 14676285 DOI: 10.1085/jgp.200308918  1
2003 Feinmark SJ, Begum R, Tsvetkov E, Goussakov I, Funk CD, Siegelbaum SA, Bolshakov VY. 12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 11427-35. PMID 14673007  1
2003 Ulens C, Siegelbaum SA. Regulation of hyperpolarization-activated HCN channels by cAMP through a gating switch in binding domain symmetry. Neuron. 40: 959-70. PMID 14659094 DOI: 10.1016/S0896-6273(03)00753-0  1
2003 Nolan MF, Malleret G, Lee KH, Gibbs E, Dudman JT, Santoro B, Yin D, Thompson RF, Siegelbaum SA, Kandel ER, Morozov A. The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cells. Cell. 115: 551-64. PMID 14651847 DOI: 10.1016/S0092-8674(03)00884-5  1
2003 Zakharenko SS, Patterson SL, Dragatsis I, Zeitlin SO, Siegelbaum SA, Kandel ER, Morozov A. Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses. Neuron. 39: 975-90. PMID 12971897 DOI: 10.1016/S0896-6273(03)00543-9  1
2003 Buttner N, Siegelbaum SA. Antagonistic modulation of a hyperpolarization-activated Cl(-) current in Aplysia sensory neurons by SCP(B) and FMRFamide. Journal of Neurophysiology. 90: 586-98. PMID 12724359 DOI: 10.1152/jn.00007.2003  1
2003 Robinson RB, Siegelbaum SA. Hyperpolarization-activated cation currents: from molecules to physiological function. Annual Review of Physiology. 65: 453-80. PMID 12471170 DOI: 10.1146/annurev.physiol.65.092101.142734  1
2003 Young EC, Siegelbaum SA. Regulation of Ion Channels by Direct Binding of Cyclic Nucleotides Handbook of Cell Signaling. 1: 233-236. DOI: 10.1016/B978-012124546-7/50401-0  1
2002 Wang J, Chen S, Nolan MF, Siegelbaum SA. Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling. Neuron. 36: 451-61. PMID 12408847 DOI: 10.1016/S0896-6273(02)00968-6  1
2002 Zakharenko SS, Zablow L, Siegelbaum SA. Altered presynaptic vesicle release and cycling during mGluR-dependent LTD. Neuron. 35: 1099-110. PMID 12354399 DOI: 10.1016/S0896-6273(02)00898-X  1
2001 Young EC, Sciubba DM, Siegelbaum SA. Efficient coupling of ligand binding to channel opening by the binding domain of a modulatory (beta) subunit of the olfactory cyclic nucleotide-gated channel. The Journal of General Physiology. 118: 523-46. PMID 11696610 DOI: 10.1085/jgp.118.5.523  1
2001 Wang J, Chen S, Siegelbaum SA. Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regions. The Journal of General Physiology. 118: 237-50. PMID 11524455 DOI: 10.1085/jgp.118.3.237  1
2001 Wainger BJ, DeGennaro M, Santoro B, Siegelbaum SA, Tibbs GR. Molecular mechanism of cAMP modulation of HCN pacemaker channels. Nature. 411: 805-10. PMID 11459060 DOI: 10.1038/35081088  1
2001 Zakharenko SS, Zablow L, Siegelbaum SA. Visualization of changes in presynaptic function during long-term synaptic plasticity. Nature Neuroscience. 4: 711-7. PMID 11426227 DOI: 10.1038/89498  1
2001 Chen S, Wang J, Siegelbaum SA. Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. The Journal of General Physiology. 117: 491-504. PMID 11331358 DOI: 10.1085/jgp.117.5.491  1
2000 Liu J, Siegelbaum SA. Change of pore helix conformational state upon opening of cyclic nucleotide-gated channels. Neuron. 28: 899-909. PMID 11163275 DOI: 10.1016/S0896-6273(00)00162-8  1
2000 Bolshakov VY, Carboni L, Cobb MH, Siegelbaum SA, Belardetti F. Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses. Nature Neuroscience. 3: 1107-12. PMID 11036267 DOI: 10.1038/80624  1
2000 Santoro B, Chen S, Luthi A, Pavlidis P, Shumyatsky GP, Tibbs GR, Siegelbaum SA. Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 5264-75. PMID 10884310  1
2000 Siegelbaum SA. Presynaptic facilitation by hyperpolarization-activated pacemaker channels. Nature Neuroscience. 3: 101-2. PMID 10649561 DOI: 10.1038/72038  1
2000 Santoro B, Chen S, Lüthi A, Pavlidis P, Shumyatsky GP, Tibbs GR, Siegelbaum SA. Molecular and Functional Heterogeneity of Hyperpolarization-Activated Pacemaker Channels in the Mouse CNS The Journal of Neuroscience. 20: 5264-5275. DOI: 10.1523/JNEUROSCI.20-14-05264.2000  0.88
1999 Janz R, Südhof TC, Hammer RE, Unni V, Siegelbaum SA, Bolshakov VY. Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron. 24: 687-700. PMID 10595519  1
1999 Siegelbaum SA. CREB can get you depressed. Neuron. 23: 414-5. PMID 10433251 DOI: 10.1016/S0896-6273(00)80792-8  1
1999 MacDermott AB, Role LW, Siegelbaum SA. Presynaptic ionotropic receptors and the control of transmitter release. Annual Review of Neuroscience. 22: 443-85. PMID 10202545 DOI: 10.1146/annurev.neuro.22.1.443  1
1999 Ma L, Zablow L, Kandel ER, Siegelbaum SA. Cyclic AMP induces functional presynaptic boutons in hippocampal CA3-CA1 neuronal cultures. Nature Neuroscience. 2: 24-30. PMID 10195176 DOI: 10.1038/4525  1
1999 Paoletti P, Young EC, Siegelbaum SA. C-Linker of cyclic nucleotide-gated channels controls coupling of ligand binding to channel gating. The Journal of General Physiology. 113: 17-34. PMID 9874685 DOI: 10.1085/jgp.113.1.17  1
1998 Armitage BA, Siegelbaum SA. Presynaptic induction and expression of homosynaptic depression at Aplysia sensorimotor neuron synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 8770-9. PMID 9786984  1
1998 Liu DT, Tibbs GR, Paoletti P, Siegelbaum SA. Constraining ligand-binding site stoichiometry suggests that a cyclic nucleotide-gated channel is composed of two functional dimers. Neuron. 21: 235-48. PMID 9697867 DOI: 10.1016/S0896-6273(00)80530-9  1
1998 Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR. Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 93: 717-29. PMID 9630217 DOI: 10.1016/S0092-8674(00)81434-8  1
1998 Tibbs GR, Liu DT, Leypold BG, Siegelbaum SA. A state-independent interaction between ligand and a conserved arginine residue in cyclic nucleotide-gated channels reveals a functional polarity of the cyclic nucleotide binding site. The Journal of Biological Chemistry. 273: 4497-505. PMID 9468504 DOI: 10.1074/jbc.273.8.4497  1
1998 Tan W, Du C, Siegelbaum SA, Role LW. Modulation of nicotinic AChR channels by prostaglandin E2 in chick sympathetic ganglion neurons. Journal of Neurophysiology. 79: 870-8. PMID 9463448  1
1997 Bolshakov VY, Golan H, Kandel ER, Siegelbaum SA. Recruitment of new sites of synaptic transmission during the cAMP-dependent late phase of LTP at CA3-CA1 synapses in the hippocampus. Neuron. 19: 635-51. PMID 9331354 DOI: 10.1016/S0896-6273(00)80377-3  1
1997 Tibbs GR, Goulding EH, Siegelbaum SA. Allosteric activation and tuning of ligand efficacy in cyclic-nucleotide-gated channels. Nature. 386: 612-5. PMID 9121585 DOI: 10.1038/386612a0  1
1996 Siegelbaum SA, Bolshakov VY. Response: Long-Term Potentiation in the CA1 Hippocampus. Science (New York, N.Y.). 271: 1605-6. PMID 17840522 DOI: 10.1126/science.271.5255.1605  1
1996 Zagotta WN, Siegelbaum SA. Structure and function of cyclic nucleotide-gated channels. Annual Review of Neuroscience. 19: 235-63. PMID 8833443 DOI: 10.1146/  1
1996 Lipka LJ, Siegelbaum SA, Robinson RB, Berman MF. An analogue of cAMP mimics developmental change in neonatal rat ventricular myocyte sodium current kinetics. The American Journal of Physiology. 270: H194-9. PMID 8769751  1
1996 McMahon HT, Bolshakov VY, Janz R, Hammer RE, Siegelbaum SA, Südhof TC. Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release. Proceedings of the National Academy of Sciences of the United States of America. 93: 4760-4. PMID 8643476 DOI: 10.1073/pnas.93.10.4760  1
1996 Liu DT, Tibbs GR, Siegelbaum SA. Subunit stoichiometry of cyclic nucleotide-gated channels and effects of subunit order on channel function. Neuron. 16: 983-90. PMID 8630256 DOI: 10.1016/S0896-6273(00)80121-X  1
1996 Malinow R, Mainen ZF. Long-term potentiation in the CA1 hippocampus. Science (New York, N.Y.). 271: 1604-6. PMID 8599121 DOI: 10.1126/science.271.5255.1604  0.52
1996 Sun ZP, Akabas MH, Goulding EH, Karlin A, Siegelbaum SA. Exposure of residues in the cyclic nucleotide-gated channel pore: P region structure and function in gating. Neuron. 16: 141-9. PMID 8562078 DOI: 10.1016/S0896-6273(00)80031-8  1
1995 Bolshakov VY, Siegelbaum SA. Hippocampal long-term depression: arachidonic acid as a potential retrograde messenger. Neuropharmacology. 34: 1581-7. PMID 8606806 DOI: 10.1016/0028-3908(95)00127-R  1
1995 Skehel PA, Armitage BA, Bartsch D, Hu Y, Kaang BK, Siegelbaum SA, Kandel ER, Martin KC. Proteins functioning in synaptic transmission at the sensory to motor synapse of Aplysia. Neuropharmacology. 34: 1379-85. PMID 8606787 DOI: 10.1016/0028-3908(95)00149-Z  1
1995 Kullmann DM, Siegelbaum SA. The site of expression of NMDA receptor-dependent LTP: new fuel for an old fire. Neuron. 15: 997-1002. PMID 7576668 DOI: 10.1016/0896-6273(95)90089-6  1
1995 Bolshakov VY, Siegelbaum SA. Regulation of hippocampal transmitter release during development and long-term potentiation. Science (New York, N.Y.). 269: 1730-4. PMID 7569903  1
1995 Martin KC, Hu Y, Armitage BA, Siegelbaum SA, Kandel ER, Kaang BK. Evidence for synaptotagmin as an inhibitory clamp on synaptic vesicle release in Aplysia neurons. Proceedings of the National Academy of Sciences of the United States of America. 92: 11307-11. PMID 7479985 DOI: 10.1073/pnas.92.24.11307  1
1994 Kramer RH, Goulding E, Siegelbaum SA. Potassium channel inactivation peptide blocks cyclic nucleotide-gated channels by binding to the conserved pore domain. Neuron. 12: 655-62. PMID 8155325 DOI: 10.1016/0896-6273(94)90220-8  1
1994 Goulding EH, Tibbs GR, Siegelbaum SA. Molecular mechanism of cyclic-nucleotide-gated channel activation. Nature. 372: 369-74. PMID 7969497 DOI: 10.1038/372369a0  1
1994 Geppert M, Bolshakov VY, Siegelbaum SA, Takei K, De Camilli P, Hammer RE, Südhof TC. The role of Rab3A in neurotransmitter release. Nature. 369: 493-7. PMID 7911226 DOI: 10.1038/369493a0  1
1994 Bolshakov VY, Siegelbaum SA. Postsynaptic induction and presynaptic expression of hippocampal long-term depression. Science (New York, N.Y.). 264: 1148-52. PMID 7909958  1
1994 Golard A, Role L, Siegelbaum SA. Substance P potentiates calcium channel modulation by somatostatin in chick sympathetic ganglia. Journal of Neurophysiology. 72: 2683-90. PMID 7534825  1
1994 Siegelbaum SA. Channel regulation. Ion channel control by tyrosine phosphorylation. Current Biology : Cb. 4: 242-5. PMID 7522914 DOI: 10.1016/S0960-9822(00)00054-3  1
1993 Eliot LS, Kandel ER, Siegelbaum SA, Blumenfeld H. Imaging terminals of Aplysia sensory neurons demonstrates role of enhanced Ca2+ influx in presynaptic facilitation. Nature. 361: 634-7. PMID 8382344 DOI: 10.1038/361634a0  1
1993 Golard A, Siegelbaum SA. Kinetic basis for the voltage-dependent inhibition of N-type calcium current by somatostatin and norepinephrine in chick sympathetic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 3884-94. PMID 8103554  1
1993 Hawkins RD, Kandel ER, Siegelbaum SA. Learning to modulate transmitter release: themes and variations in synaptic plasticity. Annual Review of Neuroscience. 16: 625-65. PMID 8096376 DOI: 10.1146/  1
1993 Goulding EH, Tibbs GR, Liu D, Siegelbaum SA. Role of H5 domain in determining pore diameter and ion permeation through cyclic nucleotide-gated channels. Nature. 364: 61-4. PMID 7686276 DOI: 10.1038/364061a0  1
1993 Golard A, Role LW, Siegelbaum SA. Protein kinase C blocks somatostatin-induced modulation of calcium current in chick sympathetic neurons. Journal of Neurophysiology. 70: 1639-43. PMID 7506759  1
1992 Kramer RH, Siegelbaum SA. Intracellular Ca2+ regulates the sensitivity of cyclic nucleotide-gated channels in olfactory receptor neurons. Neuron. 9: 897-906. PMID 1384576 DOI: 10.1016/0896-6273(92)90242-6  1
1992 Goulding EH, Ngai J, Kramer RH, Colicos S, Axel R, Siegelbaum SA, Chess A. Molecular cloning and single-channel properties of the cyclic nucleotide-gated channel from catfish olfactory neurons. Neuron. 8: 45-58. PMID 1370374 DOI: 10.1016/0896-6273(92)90107-O  1
1992 Zhang JF, Robinson RB, Siegelbaum SA. Sympathetic neurons mediate developmental change in cardiac sodium channel gating through long-term neurotransmitter action. Neuron. 9: 97-103. PMID 1352987 DOI: 10.1016/0896-6273(92)90224-2  1
1991 Volterra A, Buttner N, Siegelbaum SA. Direct opening of S-type K+ channels of Aplysia sensory neurons by 12-lipoxygenase metabolites. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 21: 727-30. PMID 1847573  1
1991 Siegelbaum SA, Kandel ER. Learning-related synaptic plasticity: LTP and LTD. Current Opinion in Neurobiology. 1: 113-20. PMID 1822291 DOI: 10.1016/0959-4388(91)90018-3  1
1991 Shuster MJ, Camardo JS, Siegelbaum SA. Comparison of the serotonin-sensitive and Ca(2+)-activated K+ channels in Aplysia sensory neurons. The Journal of Physiology. 440: 601-21. PMID 1804979  1
1991 Zhang JF, Siegelbaum SA. Effects of external protons on single cardiac sodium channels from guinea pig ventricular myocytes. The Journal of General Physiology. 98: 1065-83. PMID 1664454  1
1990 Volterra A, Siegelbaum SA. Opposing modulation of S-K+ channel activity by cyclic AMP and arachidonic acid metabolites. Progress in Clinical and Biological Research. 334: 323-38. PMID 2155435  1
1990 Blumenfeld H, Spira ME, Kandel ER, Siegelbaum SA. Facilitatory and inhibitory transmitters modulate calcium influx during action potentials in aplysia sensory neurons. Neuron. 5: 487-99. PMID 1976321 DOI: 10.1016/0896-6273(90)90088-W  1
1989 Berman MF, Camardo JS, Robinson RB, Siegelbaum SA. Single sodium channels from canine ventricular myocytes: voltage dependence and relative rates of activation and inactivation. The Journal of Physiology. 415: 503-31. PMID 2561792 DOI: 10.1113/jphysiol.1989.sp017734  1
1989 Sweatt JD, Volterra A, Edmonds B, Karl KA, Siegelbaum SA, Kandel ER. FMRFamide reverses protein phosphorylation produced by 5-HT and cAMP in Aplysia sensory neurons. Nature. 342: 275-8. PMID 2554147 DOI: 10.1038/342275a0  1
1989 Volterra A, Siegelbaum SA. Antagonistic modulation of S-K+ channel activity by cyclic AMP and arachidonic acid metabolites. Role for two G proteins. Annals of the New York Academy of Sciences. 559: 219-36. PMID 2549828  1
1989 Buttner N, Siegelbaum SA, Volterra A. Direct modulation of Aplysia S-K+ channels by a 12-lipoxygenase metabolite of arachidonic acid. Nature. 342: 553-5. PMID 2511450 DOI: 10.1038/342553a0  1
1988 Sweatt D, Volterra A, Siegelbaum SA, Kandel ER. Molecular convergence of presynaptic inhibition and presynaptic facilitation on common substrate proteins of individual sensory neurons of Aplysia. Cold Spring Harbor Symposia On Quantitative Biology. 53: 395-405. PMID 3254777  1
1988 Lotan I, Volterra A, Dash P, Siegelbaum SA, Goelet P. Blockade of ion channel expression in Xenopus oocytes with complementary DNA probes to Na+ and K+ channel mRNAs. Neuron. 1: 963-71. PMID 2856090 DOI: 10.1016/0896-6273(88)90153-5  1
1988 Volterra A, Siegelbaum SA. Role of two different guanine nucleotide-binding proteins in the antagonistic modulation of the S-type K+ channel by cAMP and arachidonic acid metabolites in Aplysia sensory neurons. Proceedings of the National Academy of Sciences of the United States of America. 85: 7810-4. PMID 2845423  1
1988 Belardetti F, Siegelbaum SA. Up- and down-modulation of single K+ channel function by distinct second messengers. Trends in Neurosciences. 11: 232-8. PMID 2471329 DOI: 10.1016/0166-2236(88)90132-4  1
1988 Chalfie M, Siegelbaum SA. Stephen M. Schuetze (1951-1987). Trends in Neurosciences. 11: 212-3. PMID 2471325 DOI: 10.1016/0166-2236(88)90128-2  1
1987 Shuster MJ, Siegelbaum SA. Pharmacological characterization of the serotonin-sensitive potassium channel of Aplysia sensory neurons. The Journal of General Physiology. 90: 587-608. PMID 2445902  1
1987 Piomelli D, Volterra A, Dale N, Siegelbaum SA, Kandel ER, Schwartz JH, Belardetti F. Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells. Nature. 328: 38-43. PMID 2439918 DOI: 10.1038/328038a0  1
1987 Belardetti F, Kandel ER, Siegelbaum SA. Neuronal inhibition by the peptide FMRFamide involves opening of S K+ channels. Nature. 325: 153-6. PMID 2433600 DOI: 10.1038/325153a0  1
1986 Belardetti F, Schacher S, Kandel ER, Siegelbaum SA. The growth cones of Aplysia sensory neurons: Modulation by serotonin of action potential duration and single potassium channel currents. Proceedings of the National Academy of Sciences of the United States of America. 83: 7094-8. PMID 16593764  1
1986 Shuster MJ, Camardo JS, Siegelbaum SA, Kandel ER. Modulation of the 'S' K+ channel by cAMP-dependent protein phosphorylation in cell-free membrane patches. Progress in Brain Research. 69: 119-32. PMID 2451837  1
1986 Siegelbaum SA, Belardetti F, Camardo JS, Shuster MJ. Modulation of the serotonin-sensitive potassium channel in Aplysia sensory neurone cell body and growth cone. The Journal of Experimental Biology. 124: 287-306. PMID 2428902  1
1986 Belardetti F, Schacher S, Siegelbaum SA. Action potentials, macroscopic and single channel currents recorded from growth cones of Aplysia neurones in culture. The Journal of Physiology. 374: 289-313. PMID 2427703 DOI: 10.1113/jphysiol.1986.sp016080  1
1985 Shuster MJ, Camardo JS, Siegelbaum SA, Kandel ER. Cyclic AMP-dependent protein kinase closes the serotonin-sensitive K+ channels of Aplysia sensory neurones in cell-free membrane patches. Nature. 313: 392-5. PMID 2578623 DOI: 10.1038/313392a0  1
1984 Siegelbaum SA, Trautmann A, Koenig J. Single acetylcholine-activated channel currents in developing muscle cells. Developmental Biology. 104: 366-79. PMID 6086429 DOI: 10.1016/0012-1606(84)90092-7  1
1983 Camardo JS, Shuster MJ, Siegelbaum SA, Kandel ER. Modulation of a specific potassium channel in sensory neurons of Aplysia by serotonin and cAMP-dependent protein phosphorylation. Cold Spring Harbor Symposia On Quantitative Biology. 48: 213-20. PMID 6327156  1
1983 Siegelbaum SA, Tsien RW. Modulation of gated ion channels as a mode of transmitter action Trends in Neurosciences. 6: 307-313. DOI: 10.1016/0166-2236(83)90145-5  1
1982 Siegelbaum SA, Camardo JS, Kandel ER. Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones. Nature. 299: 413-7. PMID 6289122 DOI: 10.1038/299413a0  1
1981 Ogden DC, Siegelbaum SA, Colquhoun D. Block of acetylcholine-activated ion channels by an uncharged local anaesthetic. Nature. 289: 596-8. PMID 6258085 DOI: 10.1038/289596a0  1
1980 Siegelbaum SA, Tsien RW. Calcium-activated transient outward current in calf cardiac Purkinje fibres. The Journal of Physiology. 299: 485-506. PMID 6770079 DOI: 10.1113/jphysiol.1980.sp013138  1
1980 Ogden DC, Siegelbaum SA. The action of benzocaine on voltage-clamped frog end-plates British Journal of Pharmacology. 69: 336P-337P.  1
1979 Kass RS, Siegelbaum SA, Tsien RW. Three-micro-electrode voltage clamp experiments in calf cardiac Purkinje fibres: is slow inward current adequately measured? The Journal of Physiology. 290: 201-25. PMID 469751 DOI: 10.1113/jphysiol.1979.sp012768  1
1979 Siegelbaum SA, Tsien RW. Calcium-activated transient outward current in cardiac Purkinje fibres [proceedings]. The Journal of Physiology. 287: 36P-37P. PMID 430419  1
1977 Siegelbaum SA, Tsien RW, Kass RS. Role of intracellular calcium in the transient outward current of calf Purkinje fibres. Nature. 269: 611-3. PMID 917108 DOI: 10.1038/269611a0  1
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