Steven A. Siegelbaum - Related publications

Affiliations: 
Columbia University, New York, NY 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Guan W, Stephens RF, Mourad O, Mehta A, Fux J, Spafford JD. Unique cysteine-enriched, D2L5 and D4L6 extracellular loops in Ca3 T-type channels alter the passage and block of monovalent and divalent ions. Scientific Reports. 10: 12404. PMID 32710088 DOI: 10.1038/s41598-020-69197-3   
2020 Cardoso FC, Marliac MA, Geoffroy C, Schmit M, Bispat A, Lewis RJ, Tuck KL, Duggan PJ. The neuronal calcium ion channel activity of constrained analogues of MONIRO-1. Bioorganic & Medicinal Chemistry. 28: 115655. PMID 32828422 DOI: 10.1016/j.bmc.2020.115655   
2020 Diniz AFA, Ferreira RC, de Souza ILL, da Silva BA. Ionic Channels as Potential Therapeutic Targets for Erectile Dysfunction: A Review. Frontiers in Pharmacology. 11: 1120. PMID 32848741 DOI: 10.3389/fphar.2020.01120   
2020 Frankel EB, Kurshan PT. All Talk, No Assembly: Voltage-Gated Calcium Channels Do Not Mediate Active Zone Formation. Neuron. 107: 593-594. PMID 32818471 DOI: 10.1016/j.neuron.2020.07.028   
2020 Vickstrom CR, Liu X, Zhang Y, Mu L, Kelly TJ, Yan X, Hu MM, Snarrenberg ST, Liu QS. T-type calcium channels contribute to burst firing in a subpopulation of medial habenula neurons. Eneuro. PMID 32719103 DOI: 10.1523/ENEURO.0201-20.2020   
2020 Schlegel AM, Haswell ES. Analyzing plant mechanosensitive ion channels expressed in giant E. coli spheroplasts by single-channel patch-clamp electrophysiology. Methods in Cell Biology. 160: 61-82. PMID 32896333 DOI: 10.1016/bs.mcb.2020.02.007   
2020 Kim JH, Won J, Oh SB. Expression of Ca3.1 T-type Calcium Channels in Acutely Isolated Adult Rat Odontoblasts. Archives of Oral Biology. 118: 104864. PMID 32847753 DOI: 10.1016/j.archoralbio.2020.104864   
2020 Kim JM, Song KS, Xu B, Wang T. Role of potassium channels in female reproductive system. Obstetrics & Gynecology Science. PMID 32838485 DOI: 10.5468/ogs.20064   
2020 Montandon GG, Cassoli JS, Peigneur S, Braga TV, Moreira Dos Santos D, Bittencourt Paiva AL, Ricardo de Moraes É, Kushmerick C, Borges MH, Richardson M, Monteiro de Castro Pimenta A, Kjeldsen F, Vasconcelos Diniz MR, Tytgat J, Elena de Lima M. GiTx1(β/κ-theraphotoxin-Gi1a), a novel toxin from the venom of Brazilian tarantula Grammostola iheringi (Mygalomorphae, Theraphosidae): Isolation, structural assessments and activity on voltage-gated ion channels. Biochimie. PMID 32717411 DOI: 10.1016/j.biochi.2020.07.008   
2020 Montandon GG, Cassoli JS, Peigneur S, Braga TV, Moreira Dos Santos D, Bittencourt Paiva AL, Ricardo de Moraes É, Kushmerick C, Borges MH, Richardson M, Monteiro de Castro Pimenta A, Kjeldsen F, Vasconcelos Diniz MR, Tytgat J, Elena de Lima M. GiTx1(β/κ-theraphotoxin-Gi1a), a novel toxin from the venom of Brazilian tarantula Grammostola iheringi (Mygalomorphae, Theraphosidae): Isolation, structural assessments and activity on voltage-gated ion channels. Biochimie. PMID 32717411 DOI: 10.1016/j.biochi.2020.07.008   
2020 Montandon GG, Cassoli JS, Peigneur S, Braga TV, Moreira Dos Santos D, Bittencourt Paiva AL, Ricardo de Moraes É, Kushmerick C, Borges MH, Richardson M, Monteiro de Castro Pimenta A, Kjeldsen F, Vasconcelos Diniz MR, Tytgat J, Elena de Lima M. GiTx1(β/κ-theraphotoxin-Gi1a), a novel toxin from the venom of Brazilian tarantula Grammostola iheringi (Mygalomorphae, Theraphosidae): Isolation, structural assessments and activity on voltage-gated ion channels. Biochimie. PMID 32717411 DOI: 10.1016/j.biochi.2020.07.008   
2020 Nam YW, Cui M, Orfali R, Viegas A, Nguyen M, Mohammed EHM, Zoghebi KA, Rahighi S, Parang K, Zhang M. Hydrophobic interactions between the HA helix and S4-S5 linker modulate apparent Ca sensitivity of SK2 channels. Acta Physiologica (Oxford, England). e13552. PMID 32865319 DOI: 10.1111/apha.13552   
2020 Lei J, Liu X, Song M, Zhou Y, Fan J, Shen X, Xu X, Kapoor I, Zhu G, Wang J. Aberrant Exon 8/8a Splicing by Downregulated PTBP (Polypyrimidine Tract-Binding Protein)-1 Increases Ca1.2 Dihydropyridine Resistance to Attenuate Vasodilation. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120315010. PMID 32787518 DOI: 10.1161/ATVBAHA.120.315010   
2020 López-Vera E, Martínez-Hernández L, Aguilar MB, Carrillo E, Gajewiak J. Studies of Conorfamide-Sr3 on Human Voltage-Gated Kv1 Potassium Channel Subtypes. Marine Drugs. 18. PMID 32823677 DOI: 10.3390/md18080425   
2020 van der Horst J, Greenwood IA, Jepps TA. Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels. Frontiers in Physiology. 11: 727. PMID 32695022 DOI: 10.3389/fphys.2020.00727   
2020 Rose P, Schleimer JH, Schreiber S. Modifications of sodium channel voltage dependence induce arrhythmia-favouring dynamics of cardiac action potentials. Plos One. 15: e0236949. PMID 32750067 DOI: 10.1371/journal.pone.0236949   
2020 Mony L, Stroebel D, Isacoff EY. Dimer interaction in the Hv1 proton channel. Proceedings of the National Academy of Sciences of the United States of America. PMID 32788354 DOI: 10.1073/pnas.2010032117   
2020 Timic Stamenic T, Feseha S, Manzella FM, Wallace D, Wilkey D, Corrigan T, Fiedler H, Doerr P, Krishnan K, Raol YH, Covey DF, Jevtovic-Todorovic V, Todorovic SM. The T-type calcium channel isoform Ca3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile. British Journal of Anaesthesia. PMID 32859366 DOI: 10.1016/j.bja.2020.07.022   
2020 Burton MJ, Cresser-Brown J, Thomas M, Portolano N, Basran J, Freeman SL, Kwon H, Bottrill AR, Llansola-Portoles MJ, Pascal AA, Jukes-Jones R, Chernova T, Schmid R, Davies NW, Storey NM, et al. Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel. The Journal of Biological Chemistry. PMID 32723862 DOI: 10.1074/jbc.RA120.014150   
2020 Sun J, Liu Y, Baudry M, Bi X. SK2 channel regulation of neuronal excitability, synaptic transmission, and brain rhythmic activity in health and diseases. Biochimica Et Biophysica Acta. Molecular Cell Research. 118834. PMID 32860835 DOI: 10.1016/j.bbamcr.2020.118834   
2020 Woo J, Jang MW, Lee J, Koh W, Mikoshiba K, Lee CJ. The molecular mechanism of synaptic activity-induced astrocytic volume transient. The Journal of Physiology. PMID 32706443 DOI: 10.1113/JP279741   
2020 Cooper G, Kang S, Perez-Rosello T, Guzman JN, Galtieri D, Xie Z, Kondapalli J, Mordell J, Silverman RB, Surmeier DJ. A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of Ca1.3 L-Type Calcium Channels. Acs Chemical Biology. PMID 32881483 DOI: 10.1021/acschembio.0c00577   
2020 Zhang Q, Dou H, Rorsman P. 'Resistance is futile?' - paradoxical inhibitory effects of K channel closure in glucagon-secreting α-cells. The Journal of Physiology. PMID 32716554 DOI: 10.1113/JP279775   
2020 Han Y, Li T, Wang S, Chen J. A Flow-Measuring Algorithm of Arc-Bottomed Open Channels through Multiple Characteristic Sensing Points of the Flow-Velocity Sensor in Agricultural Irrigation Areas. Sensors (Basel, Switzerland). 20. PMID 32806577 DOI: 10.3390/s20164504   
2020 Hung TY, Huang CW, Wu SN. High ability of zileuton ((±)-1-(1-benzo[b]thien-2-ylethyl)-1-hydroxyurea) to stimulate I but suppress I and I independently of 5-lipoxygenase inhibition. European Journal of Pharmacology. 173482. PMID 32795513 DOI: 10.1016/j.ejphar.2020.173482   
2020 Cherny VV, Musset B, Morgan D, Thomas S, Smith SME, DeCoursey TE. Engineered high-affinity zinc binding site reveals gating configurations of a human proton channel. The Journal of General Physiology. 152. PMID 32902579 DOI: 10.1085/jgp.202012664   
2020 Deng Z, Maksaev G, Schlegel AM, Zhang J, Rau M, Fitzpatrick JAJ, Haswell ES, Yuan P. Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance. Nature Communications. 11: 3690. PMID 32704140 DOI: 10.1038/s41467-020-17538-1   
2020 Boente-Juncal A, Raposo-Garcia S, Costas C, Louzao MC, Vale C, Botana LM. Partial blockade of human voltage-dependent sodium channels by the marine toxins azaspiracids. Chemical Research in Toxicology. PMID 32872774 DOI: 10.1021/acs.chemrestox.0c00216   
2020 Sherikar AS, Bhatia MS, Dhavale RP. Identification and Investigation of Chalcone Derivatives as Calcium Channel Blockers: Pharmacophore modeling, Docking studies, In-vitro screening, and 3D-QSAR Analysis. Current Computer-Aided Drug Design. PMID 32664842 DOI: 10.2174/1573409916666200714143930   
2020 McGahan K, Keener J. A mathematical model analyzing temperature threshold dependence in cold sensitive neurons. Plos One. 15: e0237347. PMID 32785272 DOI: 10.1371/journal.pone.0237347   
2020 Bai JP, Xue N, Lawal O, Nyati A, Santos-Sacchi J, Navaratnam D. Calcium-induced calcium release in proximity to hair cell BK channels revealed by PKA activation. Physiological Reports. 8: e14449. PMID 32748549 DOI: 10.14814/phy2.14449   
2020 Zhang Q, Si Y, Yang L, Wang L, Peng S, Chen Y, Chen M, Zhou X, Liu Z. Two Novel Peptide Toxins from the Spider Inhibit Tetrodotoxin-Sensitive Sodium Channels. Toxins. 12. PMID 32824960 DOI: 10.3390/toxins12090529   
2020 Morán-Zendejas R, Delgado-Ramírez M, Xu J, Valdés-Abadía B, Aréchiga-Figueroa IA, Cui M, Rodríguez-Menchaca AA. In vitro and in silico characterization of the inhibition of Kir4.1 channels by aminoglycoside antibiotics. British Journal of Pharmacology. PMID 32726456 DOI: 10.1111/bph.15214   
2020 Kim DH, Park WH, Oh HG, Jeon DC, Lim JM, Song KS. Two-Channel Graphene pH Sensor Using Semi-Ionic Fluorinated Graphene Reference Electrode. Sensors (Basel, Switzerland). 20. PMID 32731474 DOI: 10.3390/s20154184   
2020 Xie Z, Zhao Y, Yang W, Li W, Wu Y, Chen Z. Methotrexate, a small molecular scaffold targeting Kv1.3 channel extracellular pore region. Biochemical and Biophysical Research Communications. PMID 32863001 DOI: 10.1016/j.bbrc.2020.08.050   
2020 Clatot J, Neyroud N, Cox R, Souil C, Huang J, Guicheney P, Antzelevitch C. Inter-Regulation of K4.3 and Voltage-Gated Sodium Channels Underlies Predisposition to Cardiac and Neuronal Channelopathies. International Journal of Molecular Sciences. 21. PMID 32709127 DOI: 10.3390/ijms21145057   
2020 Chen LC, Zheng J, Liu J, Gong XT, Chen ZZ, Guo RX, Huang X, Zhang YP, Zhang L, Li R, Shao X, Hong W, Zhang HL. Nonadditive Transport in Multi-Channel Single-Molecule Circuits. Small (Weinheim An Der Bergstrasse, Germany). e2002808. PMID 32851802 DOI: 10.1002/smll.202002808   
2020 Szteyn K, Singh H. BK Channels as Targets for Cardioprotection. Antioxidants (Basel, Switzerland). 9. PMID 32824463 DOI: 10.3390/antiox9080760   
2020 Thorington GU, Hessinger DA. Activated L-Type Calcium Channels Inhibit Chemosensitized Nematocyst Discharge from Sea Anemone Tentacles. The Biological Bulletin. 238: 180-192. PMID 32597714 DOI: 10.1086/708947   
2020 Mondéjar-Parreño G, Barreira B, Callejo M, Morales-Cano D, Barrese V, Esquivel-Ruiz S, Olivencia MA, Macías M, Moreno L, Greenwood IA, Perez-Vizcaino F, Cogolludo A. Uncovered Contribution of Kv7 Channels to Pulmonary Vascular Tone in Pulmonary Arterial Hypertension. Hypertension (Dallas, Tex. : 1979). 76: 1134-1146. PMID 32829658 DOI: 10.1161/HYPERTENSIONAHA.120.15221   
2020 Pantazis A, Kaneko M, Angelini M, Steccanella F, Westerlund AM, Lindström SH, Nilsson M, Delemotte L, Saitta SC, Olcese R. Tracking the motion of K 1.2 voltage sensor reveals the molecular perturbations caused by a de novo mutation in a case of epilepsy. The Journal of Physiology. PMID 32833227 DOI: 10.1113/JP280438   
2020 Niu Y, Tao X, Touhara KK, MacKinnon R. Cryo-EM analysis of PIP regulation in mammalian GIRK channels. Elife. 9. PMID 32844743 DOI: 10.7554/eLife.60552   
2020 Janicki Ł, Li H, Keller S, Mishra UK, Kudrawiec R. SiN/(Al,Ga)N interface barrier in N-polar III-nitride transistor structures studied by modulation spectroscopy. Scientific Reports. 10: 12099. PMID 32694529 DOI: 10.1038/s41598-020-68963-7   
2020 Liu N, Yan F, Ma Q, Zhao J. Modulation of TRPV4 and BKCa for treatment of brain diseases. Bioorganic & Medicinal Chemistry. 28: 115609. PMID 32690264 DOI: 10.1016/j.bmc.2020.115609   
2020 Brauchi SE, Rothberg BS. Gating and calcium-sensing mechanisms of TRPA1 channels revealed. Cell Calcium. 91: 102278. PMID 32858446 DOI: 10.1016/j.ceca.2020.102278   
2020 Cobo R, García-Piqueras J, García-Mesa Y, Feito J, García-Suárez O, Vega JA. Peripheral Mechanobiology of Touch-Studies on Vertebrate Cutaneous Sensory Corpuscles. International Journal of Molecular Sciences. 21. PMID 32867400 DOI: 10.3390/ijms21176221   
2020 Rahban R, Nef S. CatSper: The complex main gate of calcium entry in mammalian spermatozoa. Molecular and Cellular Endocrinology. 110951. PMID 32712386 DOI: 10.1016/j.mce.2020.110951   
2020 Rennie KJ, Meredith FL. Persistent and resurgent Na currents in vestibular calyx afferents. Journal of Neurophysiology. PMID 32667253 DOI: 10.1152/jn.00124.2020   
2020 Lory P, Nicole S, Monteil A. Neuronal Cav3 channelopathies: recent progress and perspectives. Pflugers Archiv : European Journal of Physiology. 472: 831-844. PMID 32638069 DOI: 10.1007/s00424-020-02429-7   
2020 Ozekin YH, Isner T, Bates EA. Ion Channel Contributions to Morphological Development: Insights From the Role of Kir2.1 in Bone Development. Frontiers in Molecular Neuroscience. 13: 99. PMID 32581710 DOI: 10.3389/fnmol.2020.00099