William E. Sonntag - Publications

Affiliations: 
University of Oklahoma, Norman, OK, United States 
Area:
brain aging

184 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Hadad N, Masser DR, Logan S, Wronowski B, Mangold CA, Clark N, Otalora L, Unnikrishnan A, Ford MM, Giles CB, Wren JD, Richardson A, Sonntag WE, Stanford DR, Freeman W. Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice. Epigenetics & Chromatin. 9: 30. PMID 27413395 DOI: 10.1186/s13072-016-0080-6  1
2015 Ashpole NM, Herron JC, Mitschelen MC, Farley JA, Logan S, Yan H, Ungvari Z, Hodges EL, Csiszar A, Ikeno Y, Humphrey MB, Sonntag WE. IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 26260312 DOI: 10.1002/jbmr.2689  1
2015 Toth P, Tarantini S, Springo Z, Tucsek Z, Gautam T, Giles CB, Wren JD, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection. Aging Cell. 14: 400-8. PMID 25677910 DOI: 10.1111/acel.12315  1
2015 Springo Z, Toth P, Tarantini S, Ashpole NM, Tucsek Z, Sonntag WE, Csiszar A, Koller A, Ungvari ZI. Aging impairs myogenic adaptation to pulsatile pressure in mouse cerebral arteries. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 527-30. PMID 25605292 DOI: 10.1038/jcbfm.2014.256  1
2015 Ashpole NM, Sanders JE, Hodges EL, Yan H, Sonntag WE. Growth hormone, insulin-like growth factor-1 and the aging brain. Experimental Gerontology. 68: 76-81. PMID 25300732 DOI: 10.1016/j.exger.2014.10.002  1
2015 Gardner AW, Parker DE, Montgomery PS, Sosnowska D, Casanegra AI, Ungvari Z, Csiszar A, Sonntag WE. Gender and racial differences in endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease. Journal of Vascular Surgery. 61: 1249-57. PMID 24703977 DOI: 10.1016/j.jvs.2014.02.045  1
2014 Ungvari Z, Sonntag WE. Brain and cerebrovascular aging--new mechanisms and insights. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 69: 1307-10. PMID 25301834 DOI: 10.1093/gerona/glu187  1
2014 Toth P, Tucsek Z, Tarantini S, Sosnowska D, Gautam T, Mitschelen M, Koller A, Sonntag WE, Csiszar A, Ungvari Z. IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 1887-97. PMID 25248835 DOI: 10.1038/jcbfm.2014.156  1
2014 Yan H, Mitschelen M, Toth P, Ashpole NM, Farley JA, Hodges EL, Warrington JP, Han S, Fung KM, Csiszar A, Ungvari Z, Sonntag WE. Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 69: 1353-62. PMID 25098324 DOI: 10.1093/gerona/glu118  1
2014 Ashpole NM, Warrington JP, Mitschelen MC, Yan H, Sosnowska D, Gautam T, Farley JA, Csiszar A, Ungvari Z, Sonntag WE. Systemic influences contribute to prolonged microvascular rarefaction after brain irradiation: a role for endothelial progenitor cells. American Journal of Physiology. Heart and Circulatory Physiology. 307: H858-68. PMID 25038144 DOI: 10.1152/ajpheart.00308.2014  1
2014 Cai A, Hutchison E, Hudson J, Kawashima Y, Komori N, Singh A, Brush RS, Anderson RE, Sonntag WE, Matsumoto H, Griffin TM. Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 22: 1301-9. PMID 25008209 DOI: 10.1016/j.joca.2014.06.033  1
2014 Masser DR, Bixler GV, Brucklacher RM, Yan H, Giles CB, Wren JD, Sonntag WE, Freeman WM. Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 69: 1311-24. PMID 24994846 DOI: 10.1093/gerona/glu091  1
2014 Gardner AW, Parker DE, Montgomery PS, Sosnowska D, Casanegra AI, Ungvari Z, Csiszar A, Sonntag WE. Greater endothelial apoptosis and oxidative stress in patients with peripheral artery disease. International Journal of Vascular Medicine. 2014: 160534. PMID 24963409 DOI: 10.1155/2014/160534  1
2014 Csiszar A, Gautam T, Sosnowska D, Tarantini S, Banki E, Tucsek Z, Toth P, Losonczy G, Koller A, Reglodi D, Giles CB, Wren JD, Sonntag WE, Ungvari Z. Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats. American Journal of Physiology. Heart and Circulatory Physiology. 307: H292-306. PMID 24906921 DOI: 10.1152/ajpheart.00307.2014  1
2014 Tucsek Z, Toth P, Tarantini S, Sosnowska D, Gautam T, Warrington JP, Giles CB, Wren JD, Koller A, Ballabh P, Sonntag WE, Ungvari Z, Csiszar A. Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 69: 1339-52. PMID 24895269 DOI: 10.1093/gerona/glu080  1
2014 Toth P, Tarantini S, Tucsek Z, Ashpole NM, Sosnowska D, Gautam T, Ballabh P, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase. American Journal of Physiology. Heart and Circulatory Physiology. 306: H299-308. PMID 24322615 DOI: 10.1152/ajpheart.00744.2013  1
2014 Tucsek Z, Toth P, Sosnowska D, Gautam T, Mitschelen M, Koller A, Szalai G, Sonntag WE, Ungvari Z, Csiszar A. Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 69: 1212-26. PMID 24269929 DOI: 10.1093/gerona/glt177  1
2014 Gardner AW, Parker DE, Montgomery PS, Sosnowska D, Casanegra AI, Esponda OL, Ungvari Z, Csiszar A, Sonntag WE. Impaired vascular endothelial growth factor A and inflammation in patients with peripheral artery disease. Angiology. 65: 683-90. PMID 24006146 DOI: 10.1177/0003319713501376  1
2013 Warrington JP, Ashpole N, Csiszar A, Lee YW, Ungvari Z, Sonntag WE. Whole brain radiation-induced vascular cognitive impairment: mechanisms and implications. Journal of Vascular Research. 50: 445-57. PMID 24107797 DOI: 10.1159/000354227  1
2013 Toth P, Csiszar A, Tucsek Z, Sosnowska D, Gautam T, Koller A, Schwartzman ML, Sonntag WE, Ungvari Z. Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice. American Journal of Physiology. Heart and Circulatory Physiology. 305: H1698-708. PMID 24097425 DOI: 10.1152/ajpheart.00377.2013  1
2013 Csiszar A, Tucsek Z, Toth P, Sosnowska D, Gautam T, Koller A, Deak F, Sonntag WE, Ungvari Z. Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease. American Journal of Physiology. Heart and Circulatory Physiology. 305: H1120-30. PMID 23955715 DOI: 10.1152/ajpheart.00288.2013  1
2013 Toth P, Tucsek Z, Sosnowska D, Gautam T, Mitschelen M, Tarantini S, Deak F, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 1732-42. PMID 23942363 DOI: 10.1038/jcbfm.2013.143  1
2013 Ungvari Z, Podlutsky A, Sosnowska D, Tucsek Z, Toth P, Deak F, Gautam T, Csiszar A, Sonntag WE. Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 1443-57. PMID 23689827 DOI: 10.1093/gerona/glt057  1
2013 VanGuilder Starkey HD, Bixler GV, Sonntag WE, Freeman WM. Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus. Cellular and Molecular Neurobiology. 33: 483-8. PMID 23525710 DOI: 10.1007/s10571-013-9929-4  1
2013 VanGuilder Starkey HD, Sonntag WE, Freeman WM. Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition. The European Journal of Neuroscience. 37: 1643-58. PMID 23438185 DOI: 10.1111/ejn.12165  1
2013 Ungvari Z, Tucsek Z, Sosnowska D, Toth P, Gautam T, Podlutsky A, Csiszar A, Losonczy G, Valcarcel-Ares MN, Sonntag WE, Csiszar A. Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 877-91. PMID 23239824 DOI: 10.1093/gerona/gls242  1
2013 Bailey-Downs LC, Tucsek Z, Toth P, Sosnowska D, Gautam T, Sonntag WE, Csiszar A, Ungvari Z. Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 780-92. PMID 23213032 DOI: 10.1093/gerona/gls238  1
2013 Toth P, Csiszar A, Sosnowska D, Tucsek Z, Cseplo P, Springo Z, Tarantini S, Sonntag WE, Ungvari Z, Koller A. Treatment with the cytochrome P450 ω-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats. British Journal of Pharmacology. 168: 1878-88. PMID 23194285 DOI: 10.1111/bph.12079  1
2013 Tucsek Z, Gautam T, Sonntag WE, Toth P, Saito H, Salomao R, Szabo C, Csiszar A, Ungvari Z. Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 652-60. PMID 23183901 DOI: 10.1093/gerona/gls232  1
2013 Ungvari Z, Sosnowska D, Mason JB, Gruber H, Lee SW, Schwartz TS, Brown MK, Storm NJ, Fortney K, Sowa J, Byrne AB, Kurz T, Levy E, Sonntag WE, Austad SN, et al. Resistance to genotoxic stresses in Arctica islandica, the longest living noncolonial animal: is extreme longevity associated with a multistress resistance phenotype? The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 521-9. PMID 23051979 DOI: 10.1093/gerona/gls193  1
2013 Csiszar A, Sosnowska D, Tucsek Z, Gautam T, Toth P, Losonczy G, Colman RJ, Weindruch R, Anderson RM, Sonntag WE, Ungvari Z. Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 235-49. PMID 22904098 DOI: 10.1093/gerona/gls158  1
2013 Ungvari Z, Csiszar A, Sosnowska D, Philipp EE, Campbell CM, McQuary PR, Chow TT, Coelho M, Didier ES, Gelino S, Holmbeck MA, Kim I, Levy E, Sonntag WE, Whitby PW, et al. Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa). The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 359-67. PMID 22904097 DOI: 10.1093/gerona/gls159  1
2012 Lee YW, Cho HJ, Lee WH, Sonntag WE. Whole brain radiation-induced cognitive impairment: pathophysiological mechanisms and therapeutic targets. Biomolecules & Therapeutics. 20: 357-70. PMID 24009822 DOI: 10.4062/biomolther.2012.20.4.357  1
2012 Tanaka M, Jaruga P, Küpfer PA, Leumann CJ, Dizdaroglu M, Sonntag WE, Boon Chock P. RNA oxidation catalyzed by cytochrome c leads to its depurination and cross-linking, which may facilitate cytochrome c release from mitochondria. Free Radical Biology & Medicine. 53: 854-62. PMID 22683603 DOI: 10.1016/j.freeradbiomed.2012.05.044  1
2012 VanGuilder Starkey HD, Van Kirk CA, Bixler GV, Imperio CG, Kale VP, Serfass JM, Farley JA, Yan H, Warrington JP, Han S, Mitschelen M, Sonntag WE, Freeman WM. Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging. Journal of Molecular Neuroscience : Mn. 48: 111-26. PMID 22562814 DOI: 10.1007/s12031-012-9783-8  1
2012 Sonntag WE, Csiszar A, deCabo R, Ferrucci L, Ungvari Z. Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 587-98. PMID 22522510 DOI: 10.1093/gerona/gls115  1
2012 Deak F, Sonntag WE. Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 611-25. PMID 22503992 DOI: 10.1093/gerona/gls118  1
2012 Lee WH, Warrington JP, Sonntag WE, Lee YW. Irradiation alters MMP-2/TIMP-2 system and collagen type IV degradation in brain. International Journal of Radiation Oncology, Biology, Physics. 82: 1559-66. PMID 22429332 DOI: 10.1016/j.ijrobp.2010.12.032  1
2012 Warrington JP, Csiszar A, Mitschelen M, Lee YW, Sonntag WE. Whole brain radiation-induced impairments in learning and memory are time-sensitive and reversible by systemic hypoxia. Plos One. 7: e30444. PMID 22279591 DOI: 10.1371/journal.pone.0030444  1
2012 Vanguilder HD, Bixler GV, Sonntag WE, Freeman WM. Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory. Journal of Neurochemistry. 121: 77-98. PMID 22269040 DOI: 10.1111/j.1471-4159.2012.07671.x  1
2012 Csiszar A, Podlutsky A, Podlutskaya N, Sonntag WE, Merlin SZ, Philipp EE, Doyle K, Davila A, Recchia FA, Ballabh P, Pinto JT, Ungvari Z. Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production? The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 841-52. PMID 22219516 DOI: 10.1093/gerona/glr216  1
2012 Valcarcel-Ares MN, Gautam T, Warrington JP, Bailey-Downs L, Sosnowska D, de Cabo R, Losonczy G, Sonntag WE, Ungvari Z, Csiszar A. Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 821-9. PMID 22219515 DOI: 10.1093/gerona/glr229  1
2012 Csiszar A, Sosnowska D, Wang M, Lakatta EG, Sonntag WE, Ungvari Z. Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 811-20. PMID 22219513 DOI: 10.1093/gerona/glr228  1
2012 Nieves-Martinez E, Haynes K, Childers SR, Sonntag WE, Nicolle MM. Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats. Behavioural Brain Research. 227: 258-64. PMID 22085876 DOI: 10.1016/j.bbr.2011.10.048  1
2012 Bailey-Downs LC, Sosnowska D, Toth P, Mitschelen M, Gautam T, Henthorn JC, Ballabh P, Koller A, Farley JA, Sonntag WE, Csiszar A, Ungvari Z. Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 553-64. PMID 22080499 DOI: 10.1093/gerona/glr197  1
2012 Bailey-Downs LC, Mitschelen M, Sosnowska D, Toth P, Pinto JT, Ballabh P, Valcarcel-Ares MN, Farley J, Koller A, Henthorn JC, Bass C, Sonntag WE, Ungvari Z, Csiszar A. Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 313-29. PMID 22021391 DOI: 10.1093/gerona/glr164  1
2012 Molina DP, Ariwodola OJ, Linville C, Sonntag WE, Weiner JL, Brunso-Bechtold JK, Adams MM. Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats. Neurobiology of Aging. 33: 1938-49. PMID 22015312 DOI: 10.1016/j.neurobiolaging.2011.09.014  1
2011 VanGuilder HD, Bixler GV, Brucklacher RM, Farley JA, Yan H, Warrington JP, Sonntag WE, Freeman WM. Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment. Journal of Neuroinflammation. 8: 138. PMID 21989322 DOI: 10.1186/1742-2094-8-138  1
2011 Lee WH, Cho HJ, Sonntag WE, Lee YW. Radiation attenuates physiological angiogenesis by differential expression of VEGF, Ang-1, tie-2 and Ang-2 in rat brain. Radiation Research. 176: 753-60. PMID 21962003 DOI: 10.1667/RR2647.1  1
2011 Yan H, Mitschelen M, Bixler GV, Brucklacher RM, Farley JA, Han S, Freeman WM, Sonntag WE. Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence. The Journal of Endocrinology. 211: 27-37. PMID 21750148 DOI: 10.1530/JOE-11-0200  1
2011 Tanaka M, Han S, Küpfer PA, Leumann CJ, Sonntag WE. Quantification of oxidized levels of specific RNA species using an aldehyde reactive probe. Analytical Biochemistry. 417: 142-8. PMID 21693097 DOI: 10.1016/j.ab.2011.05.038  1
2011 Van Kirk CA, VanGuilder HD, Young M, Farley JA, Sonntag WE, Freeman WM. Age-related alterations in retinal neurovascular and inflammatory transcripts. Molecular Vision. 17: 1261-74. PMID 21633715  1
2011 Ungvari Z, Bailey-Downs L, Gautam T, Sosnowska D, Wang M, Monticone RE, Telljohann R, Pinto JT, de Cabo R, Sonntag WE, Lakatta EG, Csiszar A. Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 66: 866-75. PMID 21622983 DOI: 10.1093/gerona/glr092  1
2011 Ungvari Z, Bailey-Downs L, Sosnowska D, Gautam T, Koncz P, Losonczy G, Ballabh P, de Cabo R, Sonntag WE, Csiszar A. Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response. American Journal of Physiology. Heart and Circulatory Physiology. 301: H363-72. PMID 21602469 DOI: 10.1152/ajpheart.01134.2010  1
2011 Mitschelen M, Yan H, Farley JA, Warrington JP, Han S, Hereñú CB, Csiszar A, Ungvari Z, Bailey-Downs LC, Bass CE, Sonntag WE. Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression. Neuroscience. 185: 50-60. PMID 21524689 DOI: 10.1016/j.neuroscience.2011.04.032  1
2011 Ungvari Z, Ridgway I, Philipp EE, Campbell CM, McQuary P, Chow T, Coelho M, Didier ES, Gelino S, Holmbeck MA, Kim I, Levy E, Sosnowska D, Sonntag WE, Austad SN, et al. Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 66: 741-50. PMID 21486920 DOI: 10.1093/gerona/glr044  1
2011 VanGuilder HD, Farley JA, Yan H, Van Kirk CA, Mitschelen M, Sonntag WE, Freeman WM. Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline. Neurobiology of Disease. 43: 201-12. PMID 21440628 DOI: 10.1016/j.nbd.2011.03.012  1
2011 Ungvari Z, Sonntag WE, de Cabo R, Baur JA, Csiszar A. Mitochondrial protection by resveratrol. Exercise and Sport Sciences Reviews. 39: 128-32. PMID 21383627 DOI: 10.1097/JES.0b013e3182141f80  1
2011 Groban L, Lin M, Kassik KA, Ingram RL, Sonntag WE. Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation. Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society. 21: 81-8. PMID 21371927 DOI: 10.1016/j.ghir.2011.01.003  1
2011 Ungvari Z, Sosnowska D, Podlutsky A, Koncz P, Sonntag WE, Csiszar A. Free radical production, antioxidant capacity, and oxidative stress response signatures in fibroblasts from Lewis dwarf rats: effects of life span-extending peripubertal GH treatment. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 66: 501-10. PMID 21350246 DOI: 10.1093/gerona/glr004  1
2011 Ungvari Z, Bailey-Downs L, Gautam T, Jimenez R, Losonczy G, Zhang C, Ballabh P, Recchia FA, Wilkerson DC, Sonntag WE, Pearson K, de Cabo R, Csiszar A. Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia. American Journal of Physiology. Heart and Circulatory Physiology. 300: H1133-40. PMID 21217061 DOI: 10.1152/ajpheart.00402.2010  1
2011 Warrington JP, Csiszar A, Johnson DA, Herman TS, Ahmad S, Lee YW, Sonntag WE. Cerebral microvascular rarefaction induced by whole brain radiation is reversible by systemic hypoxia in mice. American Journal of Physiology. Heart and Circulatory Physiology. 300: H736-44. PMID 21186274 DOI: 10.1152/ajpheart.01024.2010  1
2011 Tanaka M, Han S, Song H, Küpfer PA, Leumann CJ, Sonntag WE. An assay for RNA oxidation induced abasic sites using the Aldehyde Reactive Probe. Free Radical Research. 45: 237-47. PMID 21062214 DOI: 10.3109/10715762.2010.535529  1
2011 Zuo Z, Lei H, Wang X, Wang Y, Sonntag W, Sun Z. Aging-related kidney damage is associated with a decrease in klotho expression and an increase in superoxide production. Age (Dordrecht, Netherlands). 33: 261-74. PMID 20830528 DOI: 10.1007/s11357-010-9176-2  1
2011 Tanaka M, Han S, Küpfer PA, Leumann CJ, Sonntag WE. (Free Radical Research (2011) 45, 2 (237-247)) Free Radical Research. 45: 642. DOI: 10.3109/10715762.2011.568303  1
2010 Ungvari Z, Sonntag WE, Csiszar A. Mitochondria and aging in the vascular system. Journal of Molecular Medicine (Berlin, Germany). 88: 1021-7. PMID 20714704 DOI: 10.1007/s00109-010-0667-5  1
2010 Ungvari Z, Gautam T, Koncz P, Henthorn JC, Pinto JT, Ballabh P, Yan H, Mitschelen M, Farley J, Sonntag WE, Csiszar A. Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 65: 1145-56. PMID 20713653 DOI: 10.1093/gerona/glq147  1
2010 Ungvari Z, Kaley G, de Cabo R, Sonntag WE, Csiszar A. Mechanisms of vascular aging: new perspectives. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 65: 1028-41. PMID 20576649 DOI: 10.1093/gerona/glq113  1
2010 Zhao W, Aboushwareb T, Turner C, Mathis C, Bennett C, Sonntag WE, Andersson KE, Christ G. Impaired bladder function in aging male rats. The Journal of Urology. 184: 378-85. PMID 20488483 DOI: 10.1016/j.juro.2010.03.004  1
2010 Ungvari Z, Bagi Z, Feher A, Recchia FA, Sonntag WE, Pearson K, de Cabo R, Csiszar A. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. American Journal of Physiology. Heart and Circulatory Physiology. 299: H18-24. PMID 20418481 DOI: 10.1152/ajpheart.00260.2010  1
2010 Lee WH, Sonntag WE, Lee YW. Aging attenuates radiation-induced expression of pro-inflammatory mediators in rat brain. Neuroscience Letters. 476: 89-93. PMID 20385203 DOI: 10.1016/j.neulet.2010.04.009  1
2010 VanGuilder HD, Yan H, Farley JA, Sonntag WE, Freeman WM. Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome. Journal of Neurochemistry. 113: 1577-88. PMID 20374424 DOI: 10.1111/j.1471-4159.2010.06719.x  1
2010 Lee WH, Sonntag WE, Mitschelen M, Yan H, Lee YW. Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain. International Journal of Radiation Biology. 86: 132-44. PMID 20148699 DOI: 10.3109/09553000903419346  1
2010 Nieves-Martinez E, Sonntag WE, Wilson A, Donahue A, Molina DP, Brunso-Bechtold J, Nicolle MM. Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation. The Journal of Endocrinology. 204: 31-6. PMID 19815586 DOI: 10.1677/JOE-09-0323  1
2010 Apel PJ, Ma J, Callahan M, Northam CN, Alton TB, Sonntag WE, Li Z. Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats. Muscle & Nerve. 41: 335-41. PMID 19802878 DOI: 10.1002/mus.21485  1
2009 Mitschelen M, Garteiser P, Carnes BA, Farley JA, Doblas S, Demoe JH, Warrington JP, Yan H, Nicolle MM, Towner R, Sonntag WE. Basal and hypercapnia-altered cerebrovascular perfusion predict mild cognitive impairment in aging rodents. Neuroscience. 164: 918-28. PMID 19735701 DOI: 10.1016/j.neuroscience.2009.08.070  1
2009 Hereñú CB, Sonntag WE, Morel GR, Portiansky EL, Goya RG. The ependymal route for insulin-like growth factor-1 gene therapy in the brain. Neuroscience. 163: 442-7. PMID 19531373 DOI: 10.1016/j.neuroscience.2009.06.024  1
2009 Adams MM, Elizabeth Forbes M, Constance Linville M, Riddle DR, Sonntag WE, Brunso-Bechtold JK. Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I. Growth Factors (Chur, Switzerland). 27: 181-8. PMID 19343576 DOI: 10.1080/08977190902863639  1
2009 Freeman WM, VanGuilder HD, Bennett C, Sonntag WE. Cognitive performance and age-related changes in the hippocampal proteome. Neuroscience. 159: 183-95. PMID 19135133 DOI: 10.1016/j.neuroscience.2008.12.004  1
2009 Hua K, Forbes ME, Lichtenwalner RJ, Sonntag WE, Riddle DR. Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum. Glia. 57: 1062-71. PMID 19115393 DOI: 10.1002/glia.20829  1
2009 Apel PJ, Alton T, Northam C, Ma J, Callahan M, Sonntag WE, Li Z. How age impairs the response of the neuromuscular junction to nerve transection and repair: An experimental study in rats. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 27: 385-93. PMID 18853430 DOI: 10.1002/jor.20773  1
2008 Carnes BA, Staats DO, Sonntag WE. Does senescence give rise to disease? Mechanisms of Ageing and Development. 129: 693-9. PMID 18977242 DOI: 10.1016/j.mad.2008.09.016  1
2008 Groban L, Jobe H, Lin M, Houle T, Kitzman DA, Sonntag W. Effects of short-term treadmill exercise training or growth hormone supplementation on diastolic function and exercise tolerance in old rats Journals of Gerontology - Series a Biological Sciences and Medical Sciences. 63: 911-920. PMID 18840795  1
2008 Adams MM, Shi L, Linville MC, Forbes ME, Long AB, Bennett C, Newton IG, Carter CS, Sonntag WE, Riddle DR, Brunso-Bechtold JK. Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability. Experimental Neurology. 211: 141-9. PMID 18342310 DOI: 10.1016/j.expneurol.2008.01.016  1
2008 Ingraham JP, Forbes ME, Riddle DR, Sonntag WE. Aging reduces hypoxia-induced microvascular growth in the rodent hippocampus. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 63: 12-20. PMID 18245756  1
2007 Braverman ER, Chen TJ, Prihoda TJ, Sonntag W, Meshkin B, Downs BW, Mengucci JF, Blum SH, Notaro A, Arcuri V, Varshavskiy M, Blum K. Plasma growth hormones, P300 event-related potential and test of variables of attention (TOVA) are important neuroendocrinological predictors of early cognitive decline in a clinical setting: evidence supported by structural equation modeling (SEM) parameter estimates. Age (Dordrecht, Netherlands). 29: 55-67. PMID 19424831 DOI: 10.1007/s11357-007-9030-3  1
2007 You T, Sonntag WE, Leng X, Carter CS. Lifelong caloric restriction and interleukin-6 secretion from adipose tissue: effects on physical performance decline in aged rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 62: 1082-7. PMID 17921419  1
2006 Shi L, Adams MM, Long A, Carter CC, Bennett C, Sonntag WE, Nicolle MM, Robbins M, D'Agostino R, Brunso-Bechtold JK. Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus. Radiation Research. 166: 892-9. PMID 17149974 DOI: 10.1667/RR0588.1  1
2006 Ekenstedt KJ, Sonntag WE, Loeser RF, Lindgren BR, Carlson CS. Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints. Arthritis and Rheumatism. 54: 3850-8. PMID 17133593 DOI: 10.1002/art.22254  1
2006 Sonntag WE, Bennett C, Ingram R, Donahue A, Ingraham J, Chen H, Moore T, Brunso-Bechtold JK, Riddle D. Growth hormone and IGF-I modulate local cerebral glucose utilization and ATP levels in a model of adult-onset growth hormone deficiency. American Journal of Physiology. Endocrinology and Metabolism. 291: E604-10. PMID 16912061 DOI: 10.1152/ajpendo.00012.2006  1
2006 Groban L, Pailes NA, Bennett CD, Carter CS, Chappell MC, Kitzman DW, Sonntag WE. Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin II expression in senescent rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 61: 28-35. PMID 16456192  1
2006 Lichtenwalner RJ, Forbes ME, Sonntag WE, Riddle DR. Adult-onset deficiency in growth hormone and insulin-like growth factor-I decreases survival of dentate granule neurons: insights into the regulation of adult hippocampal neurogenesis. Journal of Neuroscience Research. 83: 199-210. PMID 16385581 DOI: 10.1002/jnr.20719  1
2006 Donahue AN, Aschner M, Lash LH, Syversen T, Sonntag WE. Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus. Mechanisms of Ageing and Development. 127: 57-63. PMID 16243379 DOI: 10.1016/j.mad.2005.09.003  1
2005 Grill JD, Sonntag WE, Riddle DR. Dendritic stability in a model of adult-onset IGF-I deficiency. Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society. 15: 337-48. PMID 16143551 DOI: 10.1016/j.ghir.2005.07.002  1
2005 Kasper SO, Carter CS, Ferrario CM, Ganten D, Ferder LF, Sonntag WE, Gallagher PE, Diz DI. Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems. Physiological Genomics. 23: 311-7. PMID 16131528 DOI: 10.1152/physiolgenomics.00163.2005  1
2005 Sonntag WE, Ramsey M, Carter CS. Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging. Ageing Research Reviews. 4: 195-212. PMID 16024298 DOI: 10.1016/j.arr.2005.02.001  1
2005 Ramsey MM, Adams MM, Ariwodola OJ, Sonntag WE, Weiner JL. Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus. Journal of Neurophysiology. 94: 247-54. PMID 15985695 DOI: 10.1152/jn.00768.2004  1
2005 Sonntag WE, Carter CS, Ikeno Y, Ekenstedt K, Carlson CS, Loeser RF, Chakrabarty S, Lee S, Bennett C, Ingram R, Moore T, Ramsey M. Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span. Endocrinology. 146: 2920-32. PMID 15790724 DOI: 10.1210/en.2005-0058  1
2005 Shi L, Linville MC, Tucker EW, Sonntag WE, Brunso-Bechtold JK. Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus. Cerebral Cortex (New York, N.Y. : 1991). 15: 571-7. PMID 15319312 DOI: 10.1093/cercor/bhh158  1
2005 Ramsey M, Sonntag WE. Growth Hormone and Insulin-like Growth Factor-I and Their Interactions with Brain Circuits Involved in Cognitive Function The Somatotrophic Axis in Brain Function. 185-208. DOI: 10.1016/B978-012088484-1/50017-3  1
2005 Carter CS, Sonntag WE. Growth Hormone, Insulin-Like Growth Factor-1, and the Biology of Aging Handbook of the Biology of Aging. 534-569. DOI: 10.1016/B978-012088387-5/50023-6  1
2004 Ramsey MM, Weiner JL, Moore TP, Carter CS, Sonntag WE. Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning. Neuroscience. 129: 119-27. PMID 15489035 DOI: 10.1016/j.neuroscience.2004.08.001  1
2004 Carter CS, Cesari M, Ambrosius WT, Hu N, Diz D, Oden S, Sonntag WE, Pahor M. Angiotensin-converting enzyme inhibition, body composition, and physical performance in aged rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 59: 416-23. PMID 15123750  1
2003 Riddle DR, Sonntag WE, Lichtenwalner RJ. Microvascular plasticity in aging. Ageing Research Reviews. 2: 149-68. PMID 12605958 DOI: 10.1016/S1568-1637(02)00064-8  1
2002 Sonntag WE, Ramsey MM. Of worms, flies, dwarfs, and things that go bump in the night. Science of Aging Knowledge Environment : Sage Ke. 2002: pe17. PMID 14603010 DOI: 10.1126/sageke.2002.43.pe17  0.48
2002 Ramsey MM, Ingram RL, Cashion AB, Ng AH, Cline JM, Parlow AF, Sonntag WE. Growth hormone-deficient dwarf animals are resistant to dimethylbenzanthracine (DMBA)-induced mammary carcinogenesis. Endocrinology. 143: 4139-42. PMID 12239127 DOI: 10.1210/en.2002-220717  1
2002 Khan AS, Sane DC, Wannenburg T, Sonntag WE. Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system. Cardiovascular Research. 54: 25-35. PMID 12062358  0.6
2002 Khan AS, Sane DC, Wannenburg T, Sonntag WE. Repolarization abnormalities in heart failure Cardiovascular Research. 54: 11-12. PMID 12062355 DOI: 10.1016/S0008-6363(02)00249-3  1
2002 Carter CS, Ramsey MM, Sonntag WE. A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan. Trends in Genetics : Tig. 18: 295-301. PMID 12044358 DOI: 10.1016/S0168-9525(02)02696-3  1
2002 Carter CS, Sonntag WE, Onder G, Pahor M. Physical performance and longevity in aged rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 57: B193-7. PMID 11983716  1
2002 Carter CS, Ramsey MM, Ingram RL, Cashion AB, Cefalu WT, Wang ZQ, Sonntag WE. Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 57: B177-88. PMID 11983714  1
2002 Shi L, Poe BH, Constance Linville M, Sonntag WE, Brunso-Bechtold JK. Caloric restricted male rats demonstrate fewer synapses in layer 2 of sensorimotor cortex. Brain Research. 931: 32-40. PMID 11897086 DOI: 10.1016/S0006-8993(02)02249-7  1
2002 Poe BH, Linville MC, Sonntag WE, Brunso-Bechtold JK. Insulin-like growth factor-1 does not ameliorate the age-related decline in presumptive inhibitory synapses in layer 2 of rat sensorimotor cortex. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 26: 97-102. PMID 11853126 DOI: 10.1016/S0278-5846(01)00225-1  1
2001 Poe BH, Linville C, Riddle DR, Sonntag WE, Brunso-Bechtold JK. Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus. Neuroscience. 107: 231-8. PMID 11731097 DOI: 10.1016/S0306-4522(01)00341-4  1
2001 Lichtenwalner RJ, Forbes ME, Bennett SA, Lynch CD, Sonntag WE, Riddle DR. Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis. Neuroscience. 107: 603-13. PMID 11720784 DOI: 10.1016/S0306-4522(01)00378-5  1
2001 Khan AS, Lynch CD, Sane DC, Willingham MC, Sonntag WE. Growth hormone increases regional coronary blood flow and capillary density in aged rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 56: B364-71. PMID 11487595  1
2001 Wannenburg T, Khan AS, Sane DC, Willingham MC, Faucette T, Sonntag WE. Growth hormone reverses age-related cardiac myofilament dysfunction in rats. American Journal of Physiology. Heart and Circulatory Physiology. 281: H915-22. PMID 11454598  1
2001 Carter CS, Pahor M, Sonntag WE. Assessment of physical function in aging rodents: a strategy for improving preclinical testing. Experimental Aging Research. 27: 271-82. PMID 11441648 DOI: 10.1080/036107301300208709  1
2001 Lynch CD, Lyons D, Khan A, Bennett SA, Sonntag WE. Insulin-like growth factor-1 selectively increases glucose utilization in brains of aged animals. Endocrinology. 142: 506-9. PMID 11145617 DOI: 10.1210/endo.142.1.8053  1
2001 Sonntag WE, Brunso-Bechtold JK, Riddle DR. Age-related decreases in growth hormone and insulin-like growth factor (IGF)-I: Implications for brain aging Rejuvenation Research. 4: 311-329.  1
2001 Sonntag WE, Brunso-Bechtold JK, Riddle DR. Age-related decreases in growth hormone and insulin-like growth factor (IGF)-1: Implications for brain aging Journal of Anti-Aging Medicine. 4: 311-329.  1
2000 Sonntag WE, Lynch C, Thornton P, Khan A, Bennett S, Ingram R. The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing. Journal of Anatomy. 197: 575-85. PMID 11197531 DOI: 10.1017/S002187829900713X  1
2000 Loeser RF, Shanker G, Carlson CS, Gardin JF, Shelton BJ, Sonntag WE. Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease. Arthritis and Rheumatism. 43: 2110-20. PMID 11014363 DOI: 10.1002/1529-0131(200009)43:9<2110::AID-ANR23>3.0.CO;2-U  1
2000 Brunso-Bechtold JK, Linville MC, Sonntag WE. Age-related synaptic changes in sensorimotor cortex of the Brown Norway X fischer 344 rat. Brain Research. 872: 125-33. PMID 10924684 DOI: 10.1016/S0006-8993(00)02515-4  1
2000 Thornton PL, Ingram RL, Sonntag WE. Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 55: B106-12. PMID 10737685  1
2000 Sonntag WE, Bennett SA, Khan AS, Thornton PL, Xu X, Ingram RL, Brunso-Bechtold JK. Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats. Brain Research Bulletin. 51: 331-8. PMID 10704784 DOI: 10.1016/S0361-9230(99)00259-2  1
1999 Sonntag WE, Lynch CD, Cefalu WT, Ingram RL, Bennett SA, Thornton PL, Khan AS. Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 54: B521-38. PMID 10647962  1
1999 Lynch CD, Cooney PT, Bennett SA, Thornton PL, Khan AS, Ingram RL, Sonntag WE. Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats. Neurobiology of Aging. 20: 191-200. PMID 10537028 DOI: 10.1016/S0197-4580(99)00032-9  1
1999 Sonntag WE, Lynch CD, Bennett SA, Khan AS, Thornton PL, Cooney PT, Ingram RL, McShane T, Brunso-Bechtold JK. Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats. Neuroscience. 88: 269-79. PMID 10051206 DOI: 10.1016/S0306-4522(98)00192-4  1
1998 Markowska AL, Mooney M, Sonntag WE. Insulin-like growth factor-1 ameliorates age-related behavioral deficits. Neuroscience. 87: 559-69. PMID 9758223 DOI: 10.1016/S0306-4522(98)00143-2  1
1998 Niblock MM, Brunso-Bechtold JK, Lynch CD, Ingram RL, McShane T, Sonntag WE. Distribution and levels of insulin-like growth factor I mRNA across the life span in the Brown Norway x Fischer 344 rat brain. Brain Research. 804: 79-86. PMID 9729292 DOI: 10.1016/S0006-8993(98)00645-3  1
1997 Sonntag WE, Lynch CD, Cooney PT, Hutchins PM. Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1. Endocrinology. 138: 3515-20. PMID 9231806 DOI: 10.1210/endo.138.8.5330  1
1997 Renganathan M, Sonntag WE, Delbono O. L-type Ca2+ channel-insulin-like growth factor-1 receptor signaling impairment in aging rat skeletal muscle. Biochemical and Biophysical Research Communications. 235: 784-9. PMID 9207239 DOI: 10.1006/bbrc.1997.6881  1
1996 Xu X, Sonntag WE. Growth hormone and aging: Regulation, signal transduction and replacement therapy. Trends in Endocrinology and Metabolism: Tem. 7: 145-50. PMID 18406741 DOI: 10.1016/1043-2760(96)00043-4  1
1996 Xu X, Sonntag WE. Growth hormone-induced nuclear translocation of Stat-3 decreases with age: modulation by caloric restriction. The American Journal of Physiology. 271: E903-9. PMID 8944679  1
1996 Breese CR, D'Costa A, Rollins YD, Adams C, Booze RM, Sonntag WE, Leonard S. Expression of insulin-like growth factor-1 (IGF-1) and IGF-binding protein 2 (IGF-BP2) in the hippocampus following cytotoxic lesion of the dentate gyrus. The Journal of Comparative Neurology. 369: 388-404. PMID 8743420 DOI: 10.1002/(SICI)1096-9861(19960603)369:3<388::AID-CNE5>3.0.CO;2-1  1
1996 Xu X, Sonntag WE. Moderate caloric restriction prevents the age-related decline in growth hormone receptor signal transduction. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 51: B167-74. PMID 8612101  1
1995 Xu X, Ingram RL, Sonntag WE. Ethanol suppresses growth hormone-mediated cellular responses in liver slices. Alcoholism, Clinical and Experimental Research. 19: 1246-51. PMID 8561297 DOI: 10.1111/j.1530-0277.1995.tb01607.x  1
1995 Xu X, Bennett SA, Ingram RL, Sonntag WE. Decreases in growth hormone receptor signal transduction contribute to the decline in insulin-like growth factor I gene expression with age. Endocrinology. 136: 4551-7. PMID 7664676 DOI: 10.1210/endo.136.10.7664676  1
1995 Sonntag WE, Xu X, Ingram RL, D'Costa A. Moderate caloric restriction alters the subcellular distribution of somatostatin mRNA and increases growth hormone pulse amplitude in aged animals. Neuroendocrinology. 61: 601-8. PMID 7617139 DOI: 10.1159/000126885  1
1995 D'Costa AP, Xu X, Ingram RL, Sonntag WE. Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats. Neuroscience. 65: 805-13. PMID 7609879 DOI: 10.1016/0306-4522(94)00495-Q  1
1995 Cefalu WT, Bell-Farrow AD, Wang ZQ, Sonntag WE, Fu MX, Baynes JW, Thorpe SR. Caloric restriction decreases age-dependent accumulation of the glycoxidation products, N epsilon-(carboxymethyl)lysine and pentosidine, in rat skin collagen. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 50: B337-41. PMID 7583789 DOI: 10.1093/gerona/50A.6.B337  1
1995 Breese CR, Sonntag WE. Effect of ethanol on plasma and hepatic insulin-like growth factor regulation in pregnant rats. Alcoholism, Clinical and Experimental Research. 19: 867-73. PMID 7485832 DOI: 10.1111/j.1530-0277.1995.tb00960.x  1
1994 Breese CR, D'Costa A, Sonntag WE. Effect of in utero ethanol exposure on the postnatal ontogeny of insulin-like growth factor-1, and type-1 and type-2 insulin-like growth factor receptors in the rat brain. Neuroscience. 63: 579-89. PMID 7891866 DOI: 10.1016/0306-4522(94)90551-7  1
1993 D'Costa AP, Ingram RL, Lenham JE, Sonntag WE. The regulation and mechanisms of action of growth hormone and insulin-like growth factor 1 during normal ageing. Journal of Reproduction and Fertility. Supplement. 46: 87-98. PMID 8315618  1
1993 D'Costa AP, Lenham JE, Ingram RL, Sonntag WE. Comparison of protein synthesis in brain and peripheral tissue during aging. Relationship to insulin-like growth factor-1 and type 1 IGF receptors. Annals of the New York Academy of Sciences. 692: 253-5. PMID 8215027  1
1993 Breese CR, D'Costa A, Ingram RL, Lenham J, Sonntag WE. Long-term suppression of insulin-like growth factor-1 in rats after in utero ethanol exposure: relationship to somatic growth. The Journal of Pharmacology and Experimental Therapeutics. 264: 448-56. PMID 7678650  1
1993 D'Costa AP, Lenham JE, Ingram RL, Sonntag WE. Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats. Mechanisms of Ageing and Development. 71: 59-71. PMID 7508538 DOI: 10.1016/0047-6374(93)90035-P  1
1992 Sonntag WE, Lenham JE, Ingram RL. Effects of aging and dietary restriction on tissue protein synthesis: relationship to plasma insulin-like growth factor-1. Journal of Gerontology. 47: B159-63. PMID 1387410  1
1991 Spik KW, Boyd RL, Sonntag WE. Effect of aging on GHRF-induced growth hormone release from anterior pituitary cells in primary culture. Journal of Gerontology. 46: B72-7. PMID 1997567  1
1991 Breese CR, Ingram RL, Sonntag WE. Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins. Journal of Gerontology. 46: B180-7. PMID 1716275  1
1991 D'Costa A, Breese CR, Boyd RL, Booze RM, Sonntag WE. Attenuation of Fos-like immunoreactivity induced by a single electroconvulsive shock in brains of aging mice. Brain Research. 567: 204-11. PMID 1687805 DOI: 10.1016/0006-8993(91)90797-Y  1
1991 Breese CR, D'Costa A, Booze RM, Sonntag WE. Distribution of insulin-like growth factor 1 (IGF-1) and 2 (IGF-2) receptors in the hippocampal formation of rats and mice. Advances in Experimental Medicine and Biology. 293: 449-58. PMID 1662866  1
1990 Sonntag WE, Boyd RL, Booze RM. Somatostatin gene expression in hypothalamus and cortex of aging male rats. Neurobiology of Aging. 11: 409-16. PMID 1974326 DOI: 10.1016/0197-4580(90)90007-M  1
1989 Sonntag WE, Boyd RL. Diminished insulin-like growth factor-1 levels after chronic ethanol: relationship to pulsatile growth hormone release. Alcoholism, Clinical and Experimental Research. 13: 3-7. PMID 2646974  1
1989 Spik K, Sonntag WE. Increased pituitary response to somatostatin in aging male rats: relationship to somatostatin receptor number and affinity. Neuroendocrinology. 50: 489-94. PMID 2575235  1
1988 Sonntag WE, Boyd RL. Chronic ethanol feeding inhibits plasma levels of insulin-like growth factor-1. Life Sciences. 43: 1325-30. PMID 3172983 DOI: 10.1016/0024-3205(88)90588-7  1
1988 Sonntag WE, Gough MA. Growth hormone releasing hormone induced release of growth hormone in aging male rats: dependence on pharmacological manipulation and endogenous somatostatin release. Neuroendocrinology. 47: 482-8. PMID 2840597  1
1987 Sonntag WE, Goliszek AG, Brodish A, Eldridge JC. Diminished diurnal secretion of adrenocorticotropin (ACTH), but not corticosterone, in old male rats: possible relation to increased adrenal sensitivity to ACTH in vivo. Endocrinology. 120: 2308-15. PMID 3032584 DOI: 10.1210/endo-120-6-2308  1
1986 Hylka VW, Forman LJ, Sonntag WE, Meites J. Effect of CNS-active drugs on TRH-induced prolactin release. Life Sciences. 38: 51-7. PMID 2934599 DOI: 10.1016/0024-3205(86)90274-2  1
1986 Sonntag WE, Gottschall PE, Meites J. Increased secretion of somatostatin-28 from hypothalamic neurons of aged rats in vitro. Brain Research. 380: 229-34. PMID 2875760 DOI: 10.1016/0006-8993(86)90217-9  1
1985 Sonntag WE, Hylka VW, Meites J. Growth hormone restores protein synthesis in skeletal muscle of old male rats. Journal of Gerontology. 40: 689-94. PMID 4056323  1
1985 Forman LJ, Sonntag WE, Hylka VW, Meites J. Mediation by gonadal steroids of plasma beta-endorphin and LH in castrated female and male rats. Peptides. 6: 835-9. PMID 2934689 DOI: 10.1016/0196-9781(85)90310-9  1
1984 Sonntag WE, Forman LJ, Fiori JM, Hylka VW, Meites J. Decreased ability of old male rats to secrete luteinizing hormone (LH) is not due to alterations in pituitary LH-releasing hormone receptors. Endocrinology. 114: 1657-64. PMID 6325129 DOI: 10.1210/endo-114-5-1657  1
1984 Hylka VW, Sonntag WE, Meites J. Reduced ability of old male rats to release ACTH and corticosterone in response to CRF administration. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 175: 1-4. PMID 6320204  1
1983 Sonntag WE, Hylka VW, Meites J. Impaired ability of old male rats to secrete growth hormone in vivo but not in vitro in response to hpGRF(1-44). Endocrinology. 113: 2305-7. PMID 6416817 DOI: 10.1210/endo-113-6-2305  1
1983 Steger RW, Sonntag WE, Peluso JJ, Meites J. Effects of ovariectomy and steroid replacement on hypothalamic LHRH content in aging female rats. Neurobiology of Aging. 4: 53-7. PMID 6348573 DOI: 10.1016/0197-4580(83)90054-4  1
1983 Forman LJ, Sonntag WE, Hylka VW, Meites J. Immunoreactive beta-endorphin in the plasma, pituitary and hypothalamus of young female rats on the day of estrus and intact and chronically castrated old constant estrous female rats. Life Sciences. 33: 993-9. PMID 6310292 DOI: 10.1016/0024-3205(83)90756-7  1
1983 Forman LJ, Sonntag WE, Meites J. Elevation of plasma LH in response to systemic injection of beta-endorphin antiserum in adult male rats. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 173: 14-6. PMID 6304744  1
1983 Hylka VW, Sonntag WE, Meites J. Ovine CRF stimulates less secretion of IR-ACTH, but more secretion of IR-β-endorphin in the plasma of old than in young male rats Federation Proceedings. 42: No.2557.  1
1982 Sonntag WE, Forman LJ, Miki N, Trapp JM, Gottschall PE, Meites J. L-dopa restores amplitude of growth hormone pulses in old male rats to that observed in young male rats. Neuroendocrinology. 34: 163-8. PMID 6122169 DOI: 10.1159/000123295  1
1981 Miki N, Sonntag WE, Forman LJ, Meites J. Suppression by naloxone of rise in plasma growth hormone and prolactin induced by sucking. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 168: 330-3. PMID 7198792  1
1981 Forman LJ, Sonntag WE, Miki N, Ramos T, Meites J. Comparison of the effects of central acting drugs on prolactin release in young and old male rats. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 167: 354-8. PMID 6454894  1
1981 Forman LJ, Sonntag WE, Van Vugt DA, Meites J. Immunoreactive beta-endorphin in the plasma, pituitary and hypothalamus of young and old male rats. Neurobiology of Aging. 2: 281-4. PMID 6278345 DOI: 10.1016/0197-4580(81)90036-1  1
1981 Sonntag WE, Forman LJ, Miki N, Steger RW, Ramos T, Arimura A, Meites J. Effects of CNS active drugs and somatostatin antiserum on growth hormone release in young and old male rats. Neuroendocrinology. 33: 73-8. PMID 6115331 DOI: 10.1159/000123205  1
1981 Meites J, Sonntag WE. Hypothalamic hypophysiotropic hormones and neurotransmitter regulation: current views. Annual Review of Pharmacology and Toxicology. 21: 295-322. PMID 6112966 DOI: 10.1146/annurev.pa.21.040181.001455  1
1981 Miki N, Sonntag WE, Forman LJ, Meites J. Suppression by naloxone of rise in plasma growth hormone and prolactin induced by suckling Federation Proceedings. 40: No. 1151.  1
1981 Sonntag WE, Forman LJ, Miki N, Meites J. Effects of CNS active drugs and somatostatin antiserum on GH release in young and old male rats Federation Proceedings. 40: No. 1153.  1
1980 Huang HH, Steger RW, Sonntag WE, Meites J. Positive Feedback by Ovarian Hormones on Prolactin and LH in Old Versus Young Female Rats. Neurobiology of Aging. 1: 141-3. PMID 24279937 DOI: 10.1016/0197-4580(80)90007-X  1
1980 Sonntag WE, Steger RW, Forman LJ, Meites J. Decreased pulsatile release of growth hormone in old male rats. Endocrinology. 107: 1875-9. PMID 7428695 DOI: 10.1210/endo-107-6-1875  1
1980 Steger RW, Sonntag WE, Van Vugt DA, Forman LJ, Meites J. Reduced ability of naloxone to stimulate LH and testosterone release in aging male rats; possible relation to increase in hypothalamic met5-enkephalin. Life Sciences. 27: 747-53. PMID 7412501 DOI: 10.1016/0024-3205(80)90328-8  1
1980 Gerall AA, Dunlap JL, Sonntag WE. Reproduction in aging normal and neonatally androgenized female rats. Journal of Comparative and Physiological Psychology. 94: 556-63. PMID 7391285 DOI: 10.1037/h0077690  1
1980 Forman LJ, Sonntag WE, Miki N, Meites J. Maintenance by L-DOPA treatment of estrous cycles and LH response to estrogen in aging female rats. Experimental Aging Research. 6: 547-54. PMID 7194183 DOI: 10.1080/03610738008258386  1
1980 Huang HH, Steger RW, Sonntag WE, Meites J. Loss of positive feedback by estrogen-progesterone on prolactin release in old castrated female rats Federation Proceedings. 39: 3574.  1
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