| Year |
Citation |
Score |
| 2024 |
Stanford SM, Nguyen TP, Chang J, Zhao Z, Hackman GL, Santelli E, Sanders CM, Katiki M, Dondossola E, Brauer BL, Diaz MA, Zhan Y, Ramsey SH, Watson PA, Sankaran B, ... ... Bottini N, et al. Targeting prostate tumor low-molecular weight tyrosine phosphatase for oxidation-sensitizing therapy. Science Advances. 10: eadg7887. PMID 38295166 DOI: 10.1126/sciadv.adg7887 |
0.624 |
|
| 2023 |
Stanford SM, Bottini N. Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders. Nature Reviews. Drug Discovery. 1-22. PMID 36693907 DOI: 10.1038/s41573-022-00618-w |
0.665 |
|
| 2022 |
Imbery JF, Heinzelbecker J, Jebsen JK, McGowan M, Myklebust C, Bottini N, Stanford SM, Skånland SS, Tveita A, Tjønnfjord GE, Munthe LA, Szodoray P, Nakken B. T-helper cell regulation of CD45 phosphatase activity by galectin-1 and CD43 governs chronic lymphocytic leukaemia proliferation. British Journal of Haematology. PMID 35655388 DOI: 10.1111/bjh.18285 |
0.647 |
|
| 2021 |
Szodoray P, Andersen TK, Heinzelbecker J, Imbery JF, Huszthy PC, Stanford SM, Bogen B, Landsverk OB, Bottini N, Tveita A, Munthe LA, Nakken B. Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity. Cell Reports. 36: 109525. PMID 34380042 DOI: 10.1016/j.celrep.2021.109525 |
0.652 |
|
| 2021 |
Stanford SM, Diaz MA, Ardecky RJ, Zou J, Roosild T, Holmes ZJ, Nguyen TP, Hedrick MP, Rodiles S, Guan A, Grotegut S, Santelli E, Chung TDY, Jackson MR, Bottini N, et al. Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase. Journal of Medicinal Chemistry. PMID 33914534 DOI: 10.1021/acs.jmedchem.0c02126 |
0.652 |
|
| 2021 |
Stanford SM, Collins M, Diaz MA, Holmes ZJ, Gries P, Bliss MR, Lodi A, Zhang V, Tiziani S, Bottini N. The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy. Journal of Cellular Physiology. PMID 33615467 DOI: 10.1002/jcp.30307 |
0.679 |
|
| 2020 |
Hsieh WC, Svensson MN, Zoccheddu M, Tremblay ML, Sakaguchi S, Stanford SM, Bottini N. PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis. Jci Insight. 5. PMID 33055428 DOI: 10.1172/jci.insight.141868 |
0.662 |
|
| 2020 |
Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, ... ... Bottini N, et al. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Science Advances. 6: eaba4353. PMID 32637608 DOI: 10.1126/Sciadv.Aba4353 |
0.69 |
|
| 2020 |
Yang S, Svensson MND, Harder NHO, Hsieh WC, Santelli E, Kiosses WB, Moresco JJ, Yates JR, King CC, Liu L, Stanford SM, Bottini N. PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling. Science Signaling. 13. PMID 32184287 DOI: 10.1126/Scisignal.Aaw8130 |
0.706 |
|
| 2020 |
Wen Y, Yang S, Wakabayashi K, Svensson MND, Stanford SM, Santelli E, Bottini N. RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain. The Journal of Biological Chemistry. PMID 32139509 DOI: 10.1074/Jbc.Ra119.011808 |
0.648 |
|
| 2020 |
Stanford SM, Diaz MA, Zou JJ, Ardecky RJ, Pinkerton A, Bottini N. 1742-P: Targeting the Low Molecular Weight Protein Tyrosine Phosphatase for Obesity-Associated Diabetes Therapy Diabetes. 69. DOI: 10.2337/Db20-1742-P |
0.655 |
|
| 2019 |
Liu L, Hu F, Wang H, Wu X, Eltahan AS, Stanford S, Bottini N, Xiao H, Bottini M, Guo W, Liang XJ. Secreted Protein Acidic and Rich in Cysteine Mediated Biomimetic Delivery of Methotrexate by Albumin-Based Nanomedicines for Rheumatoid Arthritis Therapy. Acs Nano. PMID 30978282 DOI: 10.1021/Acsnano.9B01710 |
0.672 |
|
| 2019 |
Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V, Sacchetti C, Zoccheddu M, Lonic A, Li X, Boyle DL, Hammaker D, Meng TC, ... ... Bottini N, et al. PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes. Annals of the Rheumatic Diseases. PMID 30808624 DOI: 10.1136/Annrheumdis-2018-213799 |
0.683 |
|
| 2019 |
Svensson MN, Doody KM, Schmiedel BJ, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, ... ... Bottini N, et al. Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity. The Journal of Clinical Investigation. PMID 30620725 DOI: 10.1172/Jci123267 |
0.404 |
|
| 2018 |
Mustelin T, Bottini N, Stanford SM. The contribution of PTPN22 to rheumatological disease. Arthritis & Rheumatology (Hoboken, N.J.). PMID 30507064 DOI: 10.1002/Art.40790 |
0.691 |
|
| 2018 |
Zhao M, Svensson MND, Venken K, Chawla A, Liang S, Engel I, Mydel P, Day J, Elewaut D, Bottini N, Kronenberg M. Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70. Nature Communications. 9: 2627. PMID 29980684 DOI: 10.1038/S41467-018-05095-7 |
0.371 |
|
| 2018 |
STANFORD S, ZHANG V, BOTTINI N. The Tyrosine Phosphatase LMPTP Is a Key Promoter of Adipogenesis Diabetes. 67: 2421-PUB. DOI: 10.2337/Db18-2421-Pub |
0.682 |
|
| 2017 |
Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, ... Bottini N, et al. PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis. Nature Communications. 8: 1060. PMID 29057934 DOI: 10.1038/S41467-017-01168-1 |
0.686 |
|
| 2017 |
Stanford SM, Bottini N. Targeting Tyrosine Phosphatases: Time to End the Stigma. Trends in Pharmacological Sciences. PMID 28412041 DOI: 10.1016/J.Tips.2017.03.004 |
0.668 |
|
| 2017 |
Sacchetti C, Bottini N. Protein Tyrosine Phosphatases in Systemic Sclerosis: Potential Pathogenic Players and Therapeutic Targets. Current Rheumatology Reports. 19: 28. PMID 28397126 DOI: 10.1007/S11926-017-0655-7 |
0.353 |
|
| 2017 |
Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, ... ... Bottini N, et al. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nature Chemical Biology. PMID 28346406 DOI: 10.1038/Nchembio.2344 |
0.673 |
|
| 2017 |
Doody KM, Bottini N, Firestein GS. Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes. Epigenomics. PMID 28322585 DOI: 10.2217/Epi-2016-0151 |
0.301 |
|
| 2016 |
Cho JH, Kim HO, Ju YJ, Kye YC, Lee GW, Lee SW, Yun CH, Bottini N, Webster K, Goodnow CC, Surh CD, King C, Sprent J. CD45-mediated control of TCR tuning in naïve and memory CD8(+) T cells. Nature Communications. 7: 13373. PMID 27841348 DOI: 10.1038/Ncomms13373 |
0.309 |
|
| 2016 |
Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS. Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation. Jci Insight. 1. PMID 27275015 DOI: 10.1172/Jci.Insight.86580 |
0.675 |
|
| 2016 |
Szodoray P, Stanford SM, Molberg Ø, Munthe LA, Bottini N, Nakken B. T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity. The Journal of Allergy and Clinical Immunology. PMID 27056269 DOI: 10.1016/J.Jaci.2016.01.035 |
0.679 |
|
| 2015 |
Fraser HI, Howlett S, Clark J, Rainbow DB, Stanford SM, Wu DJ, Hsieh YW, Maine CJ, Christensen M, Kuchroo V, Sherman LA, Podolin PL, Todd JA, Steward CA, Peterson LB, ... Bottini N, et al. Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice. Journal of Immunology (Baltimore, Md. : 1950). PMID 26438525 DOI: 10.4049/Jimmunol.1402654 |
0.688 |
|
| 2015 |
Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Aleman Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, ... ... Bottini N, et al. "Receptor protein tyrosine phosphatase alpha enhances rheumatoid synovial fibroblast signaling and promotes arthritis in mice". Arthritis & Rheumatology (Hoboken, N.J.). PMID 26414708 DOI: 10.1002/Art.39442 |
0.697 |
|
| 2015 |
Wade F, Quijada P, Al-Haffar KM, Awad SM, Kunhi M, Toko H, Marashly Q, Belhaj K, Zahid I, Al-Mohanna F, Stanford SM, Alvarez R, Liu Y, Colak D, Jordan MC, ... ... Bottini N, et al. Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy. The Journal of Pathology. PMID 26213100 DOI: 10.1002/Path.4594 |
0.657 |
|
| 2015 |
Kiris E, Nuss JE, Stanford SM, Wanner LM, Cazares L, Maestre MF, Du HT, Gomba GY, Burnett JC, Gussio R, Bottini N, Panchal RG, Kane CD, Tessarollo L, Bavari S. Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays. Plos One. 10: e0129264. PMID 26061731 DOI: 10.1371/Journal.Pone.0129264 |
0.666 |
|
| 2015 |
Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, ... ... Bottini N, et al. Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Science Translational Medicine. 7: 288ra76. PMID 25995222 DOI: 10.1126/Scitranslmed.Aaa4616 |
0.693 |
|
| 2015 |
Doody KM, Stanford SM, Sacchetti C, Svensson MND, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, ... ... Bottini N, et al. Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aaa4616 |
0.628 |
|
| 2014 |
Stanford SM, Aleman Muench GR, Bartok B, Sacchetti C, Kiosses WB, Sharma J, Maestre MF, Bottini M, Mustelin T, Boyle DL, Firestein GS, Bottini N. TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness. Annals of the Rheumatic Diseases. PMID 25378349 DOI: 10.1136/Annrheumdis-2014-205790 |
0.686 |
|
| 2014 |
de Jong PR, Takahashi N, Harris AR, Lee J, Bertin S, Jeffries J, Jung M, Duong J, Triano AI, Lee J, Niv Y, Herdman DS, Taniguchi K, Kim CW, Dong H, ... ... Bottini N, et al. Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. The Journal of Clinical Investigation. 124: 3793-806. PMID 25083990 DOI: 10.1172/Jci72340 |
0.678 |
|
| 2014 |
Doody KM, Bottini N. "PEST control": regulation of molecular barcodes by tyrosine phosphatases. Cell Research. 24: 1027-8. PMID 25081059 DOI: 10.1038/Cr.2014.100 |
0.338 |
|
| 2014 |
Stanford SM, Bottini N. PTPN22: the archetypal non-HLA autoimmunity gene. Nature Reviews. Rheumatology. 10: 602-11. PMID 25003765 DOI: 10.1038/Nrrheum.2014.109 |
0.713 |
|
| 2014 |
Fousteri G, Jofra T, Debernardis I, Stanford SM, Laurenzi A, Bottini N, Battaglia M. The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization. Clinical and Experimental Immunology. 178: 178-89. PMID 24905474 DOI: 10.1111/Cei.12393 |
0.695 |
|
| 2014 |
Wu DJ, Zhou W, Enouz S, Orrú V, Stanford SM, Maine CJ, Rapini N, Sawatzke K, Engel I, Fiorillo E, Sherman LA, Kronenberg M, Zehn D, Peterson E, Bottini N. Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells. Plos One. 9: e86677. PMID 24498279 DOI: 10.1371/Journal.Pone.0086677 |
0.705 |
|
| 2014 |
Ahmed VF, Bottini N, Barrios AM. Covalent inhibition of the lymphoid tyrosine phosphatase. Chemmedchem. 9: 296-9. PMID 24403103 DOI: 10.1002/Cmdc.201300404 |
0.316 |
|
| 2014 |
Bottini N, Peterson EJ. Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease. Annual Review of Immunology. 32: 83-119. PMID 24364806 DOI: 10.1146/Annurev-Immunol-032713-120249 |
0.407 |
|
| 2014 |
Stanford SM, Ahmed V, Barrios AM, Bottini N. Cellular biochemistry methods for investigating protein tyrosine phosphatases. Antioxidants & Redox Signaling. 20: 2160-78. PMID 24294920 DOI: 10.1089/Ars.2013.5731 |
0.678 |
|
| 2014 |
Stanford SM, Krishnamurthy D, Kulkarni RA, Karver CE, Bruenger E, Walker LM, Ma CT, Chung TD, Sergienko E, Bottini N, Barrios AM. pCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assays. Methods (San Diego, Calif.). 65: 165-74. PMID 23886911 DOI: 10.1016/J.Ymeth.2013.07.022 |
0.628 |
|
| 2013 |
Bottini N, Firestein GS. Epigenetics in rheumatoid arthritis: a primer for rheumatologists. Current Rheumatology Reports. 15: 372. PMID 24072602 DOI: 10.1007/S11926-013-0372-9 |
0.318 |
|
| 2013 |
Kulkarni RA, Vellore NA, Bliss MR, Stanford SM, Falk MD, Bottini N, Baron R, Barrios AM. Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors. Chembiochem : a European Journal of Chemical Biology. 14: 1640-7. PMID 23956195 DOI: 10.1002/Cbic.201300273 |
0.669 |
|
| 2013 |
Kulkarni RA, Stanford SM, Vellore NA, Krishnamurthy D, Bliss MR, Baron R, Bottini N, Barrios AM. Thiuram disulfides as pseudo-irreversible inhibitors of lymphoid tyrosine phosphatase. Chemmedchem. 8: 1561-8. PMID 23873737 DOI: 10.1002/Cmdc.201300215 |
0.659 |
|
| 2013 |
Wang Y, Shaked I, Stanford SM, Zhou W, Curtsinger JM, Mikulski Z, Shaheen ZR, Cheng G, Sawatzke K, Campbell AM, Auger JL, Bilgic H, Shoyama FM, Schmeling DO, Balfour HH, ... ... Bottini N, et al. The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity. 39: 111-22. PMID 23871208 DOI: 10.1016/J.Immuni.2013.06.013 |
0.672 |
|
| 2013 |
He Y, Liu S, Menon A, Stanford S, Oppong E, Gunawan AM, Wu L, Wu DJ, Barrios AM, Bottini N, Cato AC, Zhang ZY. A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases. Journal of Medicinal Chemistry. 56: 4990-5008. PMID 23713581 DOI: 10.1021/Jm400248C |
0.689 |
|
| 2013 |
Sacchetti C, Rapini N, Magrini A, Cirelli E, Bellucci S, Mattei M, Rosato N, Bottini N, Bottini M. In vivo targeting of intratumor regulatory T cells using PEG-modified single-walled carbon nanotubes. Bioconjugate Chemistry. 24: 852-8. PMID 23682992 DOI: 10.1021/Bc400070Q |
0.33 |
|
| 2013 |
Stanford SM, Maestre MF, Campbell AM, Bartok B, Kiosses WB, Boyle DL, Arnett HA, Mustelin T, Firestein GS, Bottini N. Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival. Arthritis and Rheumatism. 65: 1171-80. PMID 23335101 DOI: 10.1002/Art.37872 |
0.699 |
|
| 2013 |
Bottini N, Firestein GS. Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nature Reviews. Rheumatology. 9: 24-33. PMID 23147896 DOI: 10.1038/Nrrheum.2012.190 |
0.345 |
|
| 2013 |
Stanford SM, Bottini M, Bottini N. The role of LMPTP in the metabolic syndrome Protein Tyrosine Phosphatase Control of Metabolism. 203-220. DOI: 10.1007/978-1-4614-7855-3_11 |
0.647 |
|
| 2012 |
Stanford SM, Panchal RG, Walker LM, Wu DJ, Falk MD, Mitra S, Damle SS, Ruble D, Kaltcheva T, Zhang S, Zhang ZY, Bavari S, Barrios AM, Bottini N. High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45. Proceedings of the National Academy of Sciences of the United States of America. 109: 13972-7. PMID 22891353 DOI: 10.1073/Pnas.1205028109 |
0.698 |
|
| 2012 |
Stanford SM, Rapini N, Bottini N. Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity. Immunology. 137: 1-19. PMID 22862552 DOI: 10.1111/J.1365-2567.2012.03591.X |
0.706 |
|
| 2012 |
Maine CJ, Hamilton-Williams EE, Cheung J, Stanford SM, Bottini N, Wicker LS, Sherman LA. PTPN22 alters the development of regulatory T cells in the thymus. Journal of Immunology (Baltimore, Md. : 1950). 188: 5267-75. PMID 22539785 DOI: 10.4049/Jimmunol.1200150 |
0.709 |
|
| 2011 |
Teruel M, Martin JE, González-Juanatey C, López-Mejias R, Miranda-Filloy JA, Blanco R, Balsa A, Pascual-Salcedo D, Rodriguez-Rodriguez L, Fernández-Gutierrez B, Ortiz AM, González-Alvaro I, Gómez-Vaquero C, Bottini N, Llorca J, et al. Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients. Arthritis Research & Therapy. 13: R116. PMID 21767392 DOI: 10.1186/Ar3401 |
0.339 |
|
| 2011 |
Stanford SM, Krishnamurthy D, Falk MD, Messina R, Debnath B, Li S, Liu T, Kazemi R, Dahl R, He Y, Yu X, Chan AC, Zhang ZY, Barrios AM, Woods VL, ... ... Bottini N, et al. Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. Journal of Medicinal Chemistry. 54: 1640-54. PMID 21341673 DOI: 10.1021/Jm101202J |
0.704 |
|
| 2010 |
Delogu LG, Stanford SM, Santelli E, Magrini A, Bergamaschi A, Motamedchaboki K, Rosato N, Mustelin T, Bottini N, Bottini M. Carbon nanotube-based nanocarriers: the importance of keeping it clean. Journal of Nanoscience and Nanotechnology. 10: 5293-301. PMID 21125885 DOI: 10.1166/Jnn.2010.3083 |
0.647 |
|
| 2010 |
Sebastiani GD, Bottini N, Greco E, Saccucci P, Canu G, Lucarelli P, Gloria-Bottini F, Fontana L. A study of adenosine-deaminase genetic polymorphism in rheumatoid arthritis International Journal of Immunopathology and Pharmacology. 23: 791-795. PMID 20943049 DOI: 10.1177/039463201002300313 |
0.312 |
|
| 2010 |
Fiorillo E, Orrú V, Stanford SM, Liu Y, Salek M, Rapini N, Schenone AD, Saccucci P, Delogu LG, Angelini F, Manca Bitti ML, Schmedt C, Chan AC, Acuto O, Bottini N. Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue. The Journal of Biological Chemistry. 285: 26506-18. PMID 20538612 DOI: 10.1074/Jbc.M110.111104 |
0.707 |
|
| 2010 |
Stanford SM, Mustelin TM, Bottini N. Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases. Seminars in Immunopathology. 32: 127-36. PMID 20204370 DOI: 10.1007/S00281-010-0201-4 |
0.698 |
|
| 2010 |
Karver MR, Krishnamurthy D, Bottini N, Barrios AM. Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase. Journal of Inorganic Biochemistry. 104: 268-73. PMID 20083307 DOI: 10.1016/J.Jinorgbio.2009.12.012 |
0.328 |
|
| 2009 |
Karver MR, Krishnamurthy D, Kulkarni RA, Bottini N, Barrios AM. Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of Au(I) complexes. Journal of Medicinal Chemistry. 52: 6912-8. PMID 19888762 DOI: 10.1021/Jm901220M |
0.335 |
|
| 2009 |
Shu YH, Hartiala J, Xiang AH, Trigo E, Lawrence JM, Allayee H, Buchanan TA, Bottini N, Watanabe RM. Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans. The Journal of Clinical Endocrinology and Metabolism. 94: 4094-102. PMID 19622628 DOI: 10.1210/Jc.2008-2751 |
0.301 |
|
| 2009 |
Liu Y, Stanford SM, Jog SP, Fiorillo E, Orrú V, Comai L, Bottini N. Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain. Biochemistry. 48: 7525-32. PMID 19586056 DOI: 10.1021/Bi900332F |
0.667 |
|
| 2009 |
Delogu LG, Magrini A, Bergamaschi A, Rosato N, Dawson MI, Bottini N, Bottini M. Conjugation of antisense oligonucleotides to PEGylated carbon nanotubes enables efficient knockdown of PTPN22 in T lymphocytes. Bioconjugate Chemistry. 20: 427-31. PMID 19243140 DOI: 10.1021/Bc800540J |
0.343 |
|
| 2009 |
Orrú V, Tsai SJ, Rueda B, Fiorillo E, Stanford SM, Dasgupta J, Hartiala J, Zhao L, Ortego-Centeno N, D'Alfonso S, Arnett FC, Wu H, Gonzalez-Gay MA, Tsao BP, ... ... Bottini N, et al. A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Human Molecular Genetics. 18: 569-79. PMID 18981062 DOI: 10.1093/Hmg/Ddn363 |
0.673 |
|
| 2008 |
Krishnamurthy D, Karver MR, Fiorillo E, Orrú V, Stanford SM, Bottini N, Barrios AM. Gold(I)-mediated inhibition of protein tyrosine phosphatases: a detailed in vitro and cellular study. Journal of Medicinal Chemistry. 51: 4790-5. PMID 18605719 DOI: 10.1021/Jm800101W |
0.684 |
|
| 2008 |
Cato MH, D'Annibale F, Mills DM, Cerignoli F, Dawson MI, Bergamaschi E, Bottini N, Magrini A, Bergamaschi A, Rosato N, Rickert RC, Mustelin T, Bottini M. Cell-type specific and cytoplasmic targeting of PEGylated carbon nanotube-based nanoassemblies. Journal of Nanoscience and Nanotechnology. 8: 2259-69. PMID 18572636 DOI: 10.1166/Jnn.2008.501 |
0.307 |
|
| 2008 |
Saccucci P, Del Duca E, Rapini N, Verrotti A, Piccinini S, Maccari A, Canu G, Angelini F, Fontana L, Giannini C, Chiarelli F, Manca Bitti ML, Bottini N. Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy. Tissue Antigens. 71: 234-7. PMID 18179648 DOI: 10.1111/J.1399-0039.2007.00987.X |
0.34 |
|
| 2008 |
Zoledziewska M, Perra C, Orrù V, Moi L, Frongia P, Congia M, Bottini N, Cucca F. Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes. Diabetes. 57: 229-34. PMID 17934143 DOI: 10.2337/Db07-0289 |
0.306 |
|
| 2007 |
Vang T, Miletic AV, Bottini N, Mustelin T. Protein tyrosine phosphatase PTPN22 in human autoimmunity. Autoimmunity. 40: 453-61. PMID 17729039 DOI: 10.1080/08916930701464897 |
0.368 |
|
| 2007 |
Nicotra M, Bottini N, La Torre M, Amante A, Bottini E, Gloria-Bottini F. Repeated spontaneous abortion. Cooperative effects of ADA and ACP1 genetic polymorphisms. American Journal of Reproductive Immunology (New York, N.Y. : 1989). 58: 1-10. PMID 17565542 DOI: 10.1111/J.1600-0897.2007.00483.X |
0.323 |
|
| 2007 |
Gloria-Bottini F, Bottini N, Renzetti G, Bottini E. ACP1 and Th class of immunological disease: Evidence of interaction with gender International Archives of Allergy and Immunology. 143: 170-176. PMID 17284925 DOI: 10.1159/000099308 |
0.327 |
|
| 2007 |
Zhao L, Liu Y, Fiorillo E, Stanford S, Orru V, Bottini N. Functional Characterization of the Autoimmune-associated LYP-W620 Variant Clinical Immunology. 123: S127. DOI: 10.1016/J.Clim.2007.03.540 |
0.647 |
|
| 2006 |
Bottini N, Vang T, Cucca F, Mustelin T. Role of PTPN22 in type 1 diabetes and other autoimmune diseases. Seminars in Immunology. 18: 207-13. PMID 16697661 DOI: 10.1016/J.Smim.2006.03.008 |
0.353 |
|
| 2006 |
Nika K, Charvet C, Williams S, Tautz L, Bruckner S, Rahmouni S, Bottini N, Schoenberger SP, Baier G, Altman A, Mustelin T. Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation. Molecular and Cellular Biology. 26: 1806-16. PMID 16479000 DOI: 10.1128/Mcb.26.5.1806-1816.2006 |
0.379 |
|
| 2005 |
Mijakovic I, Petranovic D, Bottini N, Deutscher J, Ruhdal Jensen P. Protein-tyrosine phosphorylation in Bacillus subtilis. Journal of Molecular Microbiology and Biotechnology. 9: 189-97. PMID 16415592 DOI: 10.1159/000089647 |
0.325 |
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| 2005 |
Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, et al. Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. The Journal of Experimental Medicine. 202: 1587-97. PMID 16330817 DOI: 10.1084/Jem.20051108 |
0.331 |
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| 2005 |
Vang T, Congia M, Macis MD, Musumeci L, Orrú V, Zavattari P, Nika K, Tautz L, Taskén K, Cucca F, Mustelin T, Bottini N. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nature Genetics. 37: 1317-9. PMID 16273109 DOI: 10.1038/Ng1673 |
0.395 |
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| 2005 |
Wu H, Cantor RM, Graham DS, Lingren CM, Farwell L, Jager PL, Bottini N, Grossman JM, Wallace DJ, Hahn BH, Julkunen H, Hebert LA, Rovin BH, Birmingham DJ, Rioux JD, et al. Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease. Arthritis and Rheumatism. 52: 2396-402. PMID 16052563 DOI: 10.1002/Art.21223 |
0.308 |
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| 2005 |
Mijakovic I, Musumeci L, Tautz L, Petranovic D, Edwards RA, Jensen PR, Mustelin T, Deutscher J, Bottini N. In vitro characterization of the Bacillus subtilis protein tyrosine phosphatase YwqE. Journal of Bacteriology. 187: 3384-90. PMID 15866923 DOI: 10.1128/Jb.187.10.3384-3390.2005 |
0.301 |
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| 2005 |
Mustelin T, Vang T, Bottini N. Protein tyrosine phosphatases and the immune response. Nature Reviews. Immunology. 5: 43-57. PMID 15630428 DOI: 10.1038/Nri1530 |
0.372 |
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| 2005 |
Ladner MB, Bottini N, Valdes AM, Noble JA. Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes. Human Immunology. 66: 60-4. PMID 15620463 DOI: 10.1016/J.Humimm.2004.09.016 |
0.384 |
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| 2005 |
Tautz L, Bruckner S, Sareth S, Alonso A, Bogetz J, Bottini N, Pellecchia M, Mustelin T. Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds. The Journal of Biological Chemistry. 280: 9400-8. PMID 15615724 DOI: 10.1074/Jbc.M413122200 |
0.373 |
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| 2004 |
Huynh H, Bottini N, Williams S, Cherepanov V, Musumeci L, Saito K, Bruckner S, Vachon E, Wang X, Kruger J, Chow CW, Pellecchia M, Monosov E, Greer PA, Trimble W, et al. Control of vesicle fusion by a tyrosine phosphatase. Nature Cell Biology. 6: 831-9. PMID 15322554 DOI: 10.1038/Ncb1164 |
0.329 |
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| 2004 |
Bottini N, Gloria-Bottini F, Borgiani P, Antonacci E, Lucarelli P, Bottini E. Type 2 diabetes and the genetics of signal transduction: A study of interaction between adenosine deaminase and acid phosphatase locus 1 polymorphisms Metabolism: Clinical and Experimental. 53: 995-1001. PMID 15281007 DOI: 10.1016/J.Metabol.2004.03.006 |
0.345 |
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| 2004 |
Mustelin T, Alonso A, Bottini N, Huynh H, Rahmouni S, Nika K, Louis-dit-Sully C, Tautz L, Togo SH, Bruckner S, Mena-Duran AV, al-Khouri AM. Protein tyrosine phosphatases in T cell physiology. Molecular Immunology. 41: 687-700. PMID 15220004 DOI: 10.1016/J.Molimm.2004.04.015 |
0.391 |
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| 2004 |
Alonso A, Sasin J, Bottini N, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustelin T. Protein tyrosine phosphatases in the human genome Cell. 117: 699-711. PMID 15186772 DOI: 10.1016/J.Cell.2004.05.018 |
0.32 |
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| 2004 |
Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, Rostamkhani M, MacMurray J, Meloni GF, Lucarelli P, Pellecchia M, Eisenbarth GS, Comings D, Mustelin T. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nature Genetics. 36: 337-8. PMID 15004560 DOI: 10.1038/Ng1323 |
0.358 |
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| 2004 |
Alonso A, Bottini N, Bruckner S, Rahmouni S, Williams S, Schoenberger SP, Mustelin T. Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH. The Journal of Biological Chemistry. 279: 4922-8. PMID 14623872 DOI: 10.1074/Jbc.M308978200 |
0.386 |
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| 2004 |
Nika K, Hyunh H, Williams S, Paul S, Bottini N, Taskén K, Lombroso PJ, Mustelin T. Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location. The Biochemical Journal. 378: 335-42. PMID 14613483 DOI: 10.1042/Bj20031244 |
0.366 |
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| 2003 |
Huynh H, Wang X, Li W, Bottini N, Williams S, Nika K, Ishihara H, Godzik A, Mustelin T. Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells. Journal of Immunology (Baltimore, Md. : 1950). 171: 6661-71. PMID 14662869 DOI: 10.4049/Jimmunol.171.12.6661 |
0.332 |
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| 2003 |
Mustelin T, Rahmouni S, Bottini N, Alonso A. Role of protein tyrosine phosphatases in T cell activation. Immunological Reviews. 191: 139-47. PMID 12614357 DOI: 10.1034/J.1600-065X.2003.00014.X |
0.394 |
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| 2002 |
Bottini N, Saccucci P, Piciullo A, Iannetti P, Lucarini N, Lucarelli P, Gloria-Bottini F, Curatolo P. Convulsive disorder and the genetics of signal transduction; a study of a low molecular weight protein tyrosine phosphatase in a pediatric sample. Neuroscience Letters. 333: 159-62. PMID 12429372 DOI: 10.1016/S0304-3940(02)00758-9 |
0.308 |
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| 2002 |
Bottini N, Mao XQ, Borgiani P, Saccucci P, Stefanini L, Greco E, Fontana L, Shirakawa T, Hopkin JM. Low molecular weight PTP-IL-4RA interaction in atopy predisposition. Allergy. 57: 10-2. PMID 12144546 DOI: 10.1034/J.1398-9995.57.S72.4.X |
0.304 |
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| 2002 |
Birle D, Bottini N, Williams S, Huynh H, deBelle I, Adamson E, Mustelin T. Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation. Journal of Immunology (Baltimore, Md. : 1950). 169: 286-91. PMID 12077256 DOI: 10.4049/Jimmunol.169.1.286 |
0.366 |
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| 2002 |
Bottini N, Stefanini L, Williams S, Alonso A, Jascur T, Abraham RT, Couture C, Mustelin T. Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP). The Journal of Biological Chemistry. 277: 24220-4. PMID 11976341 DOI: 10.1074/Jbc.M202885200 |
0.398 |
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| 2002 |
Bottini N, Meloni GF, Borgiani P, Giorgini A, Buzzetti R, Pozzilli P, Lucarelli P, Gloria-Bottini F. Genotypes of cytosolic low-molecular-weight protein-tyrosine-phosphatase correlate with age at onset of type 1 diabetes in a sex-specific manner Metabolism: Clinical and Experimental. 51: 419-422. PMID 11912546 DOI: 10.1053/Meta.2002.31317 |
0.33 |
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| 2001 |
Bottini E, Palmarino R, Lucarelli P, Lista F, Bottini N. ACP1 and human adaptability: Association with past malarial morbidity in the Sardinian population American Journal of Human Biology. 13: 753-760. PMID 11748814 DOI: 10.1002/Ajhb.1121 |
0.302 |
|
| 2000 |
Bottini N, Gloria-Bottini F, Lucarini N, Ronchetti PG, Fontana L. Inflammatory bowel disease: Are there gender differences in the genetics of signal transduction? A preliminary study of cytosolic low molecular weight protein tyrosine phosphatase Disease Markers. 16: 163-166. PMID 11381200 DOI: 10.1155/2000/101739 |
0.318 |
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| 1998 |
Bottini E, Cosmi E, Nicotra M, Santeusanio G, La Torre M, Bottini N, Lucarini N. The genetics of signal transduction and the feto-maternal relationship. A study of cytosolic low molecular weight phosphotyrosine phosphatase. Disease Markers. 14: 143-50. PMID 10427472 DOI: 10.1155/1998/861096 |
0.36 |
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