Bridget M. Lumb - Publications

University of Bristol, Bristol, England, United Kingdom 
Descending control of nociception, PAG

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Donaldson LF, Lumb BM. Top-down control of pain. The Journal of Physiology. 595: 4139-4140. PMID 28664606 DOI: 10.1113/JP273361  0.88
2017 Koutsikou S, Apps R, Lumb BM. Top down control of spinal sensorimotor circuits essential for survival. The Journal of Physiology. PMID 28294351 DOI: 10.1113/JP273360  0.92
2016 Watson TC, Cerminara NL, Lumb BM, Apps R. Neural Correlates of Fear in the Periaqueductal Gray. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 12707-12719. PMID 27974618 DOI: 10.1523/JNEUROSCI.1100-16.2016  0.92
2015 Koutsikou S, Watson TC, Crook JJ, Leith JL, Lawrenson CL, Apps R, Lumb BM. The Periaqueductal Gray Orchestrates Sensory and Motor Circuits at Multiple Levels of the Neuraxis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 14132-47. PMID 26490855 DOI: 10.1523/JNEUROSCI.0261-15.2015  1
2015 Hainer C, Mosienko V, Koutsikou S, Crook JJ, Gloss B, Kasparov S, Lumb BM, Alenina N. Beyond Gene Inactivation: Evolution of Tools for Analysis of Serotonergic Circuitry. Acs Chemical Neuroscience. 6: 1116-29. PMID 26132472 DOI: 10.1021/acschemneuro.5b00045  0.92
2015 Hsieh MT, Donaldson LF, Lumb BM. Differential contributions of A- and C-nociceptors to primary and secondary inflammatory hypersensitivity in the rat. Pain. 156: 1074-83. PMID 25760474 DOI: 10.1097/j.pain.0000000000000151  0.88
2015 Hughes S, Hickey L, Donaldson LF, Lumb BM, Pickering AE. Intrathecal reboxetine suppresses evoked and ongoing neuropathic pain behaviours by restoring spinal noradrenergic inhibitory tone. Pain. 156: 328-34. PMID 25599454 DOI: 10.1097/01.j.pain.0000460313.73358.31  1
2015 Hainer C, Mosienko V, Koutsikou S, Crook JJ, Gloss B, Kasparov S, Lumb BM, Alenina N. Beyond Gene Inactivation: Evolution of Tools for Analysis of Serotonergic Circuitry Acs Chemical Neuroscience. 6: 1116-1129. DOI: 10.1021/acschemneuro.5b00045  1
2014 Lumb BM. Descending controls: how to harness for the relief of pain? The Journal of Physiology. 592: 4097. PMID 25274749 DOI: 10.1113/jphysiol.2014.280750  1
2014 Leith JL, Wilson AW, You HJ, Lumb BM, Donaldson LF. Periaqueductal grey cyclooxygenase-dependent facilitation of C-nociceptive drive and encoding in dorsal horn neurons in the rat. The Journal of Physiology. 592: 5093-107. PMID 25239460 DOI: 10.1113/jphysiol.2014.275909  1
2014 Drake RA, Hulse RP, Lumb BM, Donaldson LF. The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent input. The Journal of Physiology. 592: 3611-24. PMID 24879873 DOI: 10.1113/jphysiol.2013.266494  1
2014 Lei J, Sun T, Lumb BM, You HJ. Roles of the periaqueductal gray in descending facilitatory and inhibitory controls of intramuscular hypertonic saline induced muscle nociception. Experimental Neurology. 257: 88-94. PMID 24792920 DOI: 10.1016/j.expneurol.2014.04.019  1
2014 Hickey L, Li Y, Fyson SJ, Watson TC, Perrins R, Hewinson J, Teschemacher AG, Furue H, Lumb BM, Pickering AE. Optoactivation of locus ceruleus neurons evokes bidirectional changes in thermal nociception in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 4148-60. PMID 24647936 DOI: 10.1523/JNEUROSCI.4835-13.2014  1
2014 Koutsikou S, Crook JJ, Earl EV, Leith JL, Watson TC, Lumb BM, Apps R. Neural substrates underlying fear-evoked freezing: the periaqueductal grey-cerebellar link. The Journal of Physiology. 592: 2197-213. PMID 24639484 DOI: 10.1113/jphysiol.2013.268714  1
2014 Weerasinghe NS, Lumb BM, Apps R, Koutsikou S, Murrell JC. Objective validation of central sensitization in the rat UVB and heat rekindling model. European Journal of Pain (London, England). 18: 1199-206. PMID 24590815 DOI: 10.1002/j.1532-2149.2014.00469.x  1
2014 Flavell CR, Cerminara NL, Apps R, Lumb BM. Spino-olivary projections in the rat are anatomically separate from postsynaptic dorsal column projections. The Journal of Comparative Neurology. 522: 2179-90. PMID 24357064 DOI: 10.1002/cne.23527  1
2013 Hughes SW, Hickey L, Hulse RP, Lumb BM, Pickering AE. Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury. Pain. 154: 1680-90. PMID 23707289 DOI: 10.1016/j.pain.2013.05.010  1
2013 Watson TC, Koutsikou S, Cerminara NL, Flavell CR, Crook JJ, Lumb BM, Apps R. The olivo-cerebellar system and its relationship to survival circuits. Frontiers in Neural Circuits. 7: 72. PMID 23630468 DOI: 10.3389/fncir.2013.00072  1
2011 Davies EK, Boyle Y, Chizh BA, Lumb BM, Murrell JC. Ultraviolet B-induced inflammation in the rat: a model of secondary hyperalgesia? Pain. 152: 2844-51. PMID 22019137 DOI: 10.1016/j.pain.2011.09.015  1
2011 Obara I, Tochiki KK, Géranton SM, Carr FB, Lumb BM, Liu Q, Hunt SP. Systemic inhibition of the mammalian target of rapamycin (mTOR) pathway reduces neuropathic pain in mice. Pain. 152: 2582-95. PMID 21917376 DOI: 10.1016/j.pain.2011.07.025  1
2010 Leith JL, Koutsikou S, Lumb BM, Apps R. Spinal processing of noxious and innocuous cold information: differential modulation by the periaqueductal gray. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4933-42. PMID 20371814 DOI: 10.1523/JNEUROSCI.0122-10.2010  1
2010 Dunham JP, Leith JL, Lumb BM, Donaldson LF. Transient receptor potential channel A1 and noxious cold responses in rat cutaneous nociceptors. Neuroscience. 165: 1412-9. PMID 19961905 DOI: 10.1016/j.neuroscience.2009.11.065  1
2009 Géranton SM, Jiménez-Díaz L, Torsney C, Tochiki KK, Stuart SA, Leith JL, Lumb BM, Hunt SP. A rapamycin-sensitive signaling pathway is essential for the full expression of persistent pain states. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15017-27. PMID 19940197 DOI: 10.1523/JNEUROSCI.3451-09.2009  1
2009 Cerminara NL, Koutsikou S, Lumb BM, Apps R. The periaqueductal grey modulates sensory input to the cerebellum: a role in coping behaviour? The European Journal of Neuroscience. 29: 2197-206. PMID 19453624 DOI: 10.1111/j.1460-9568.2009.06760.x  1
2009 Heinricher MM, Tavares I, Leith JL, Lumb BM. Descending control of nociception: Specificity, recruitment and plasticity. Brain Research Reviews. 60: 214-25. PMID 19146877 DOI: 10.1016/j.brainresrev.2008.12.009  1
2008 Jiménez-Díaz L, Géranton SM, Passmore GM, Leith JL, Fisher AS, Berliocchi L, Sivasubramaniam AK, Sheasby A, Lumb BM, Hunt SP. Local translation in primary afferent fibers regulates nociception. Plos One. 3: e1961. PMID 18398477 DOI: 10.1371/journal.pone.0001961  1
2008 Parry DM, Macmillan FM, Koutsikou S, McMullan S, Lumb BM. Separation of A- versus C-nociceptive inputs into spinal-brainstem circuits. Neuroscience. 152: 1076-85. PMID 18328632 DOI: 10.1016/j.neuroscience.2008.01.018  1
2008 Simpson DA, Headley PM, Lumb BM. Selective inhibition from the anterior hypothalamus of C- versus A-fibre mediated spinal nociception. Pain. 136: 305-12. PMID 17822851 DOI: 10.1016/j.pain.2007.07.008  1
2008 Waters AJ, Lumb BM. Descending control of spinal nociception from the periaqueductal grey distinguishes between neurons with and without C-fibre inputs. Pain. 134: 32-40. PMID 17467173 DOI: 10.1016/j.pain.2007.03.025  1
2007 Leith JL, Wilson AW, Donaldson LF, Lumb BM. Cyclooxygenase-1-derived prostaglandins in the periaqueductal gray differentially control C- versus A-fiber-evoked spinal nociception. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11296-305. PMID 17942724 DOI: 10.1523/JNEUROSCI.2586-07.2007  1
2007 Koutsikou S, Parry DM, MacMillan FM, Lumb BM. Laminar organization of spinal dorsal horn neurones activated by C- vs. A-heat nociceptors and their descending control from the periaqueductal grey in the rat. The European Journal of Neuroscience. 26: 943-52. PMID 17714188 DOI: 10.1111/j.1460-9568.2007.05716.x  1
2006 McMullan S, Lumb BM. Spinal dorsal horn neuronal responses to myelinated versus unmyelinated heat nociceptors and their modulation by activation of the periaqueductal grey in the rat. The Journal of Physiology. 576: 547-56. PMID 16916903 DOI: 10.1113/jphysiol.2006.117754  1
2006 McMullan S, Lumb BM. Midbrain control of spinal nociception discriminates between responses evoked by myelinated and unmyelinated heat nociceptors in the rat. Pain. 124: 59-68. PMID 16650581 DOI: 10.1016/j.pain.2006.03.015  1
2006 Lumb BM. Central processing of input signals arising from myelinated and nonmyelinated nociceptors: In vivo studies Neurophysiology. 38: 286-293. DOI: 10.1007/s11062-006-0058-2  1
2004 McMullan S, Simpson DA, Lumb BM. A reliable method for the preferential activation of C- or A-fibre heat nociceptors. Journal of Neuroscience Methods. 138: 133-9. PMID 15325121 DOI: 10.1016/j.jneumeth.2004.03.020  1
2004 Lumb BM. Hypothalamic and midbrain circuitry that distinguishes between escapable and inescapable pain. News in Physiological Sciences : An International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society. 19: 22-6. PMID 14739399 DOI: 10.1152/nips.01467.2003  1
2002 Lumb BM. Can the anatomic and neurochemical organization within the caudal ventrolateral medulla provide the framework on which to develop therapeutic strategies? The Journal of Pain : Official Journal of the American Pain Society. 3: 347-9; discussion 35. PMID 14622735 DOI: 10.1054/jpai.2002.127776  1
2002 Lumb BM. Inescapable and escapable pain is represented in distinct hypothalamic-midbrain circuits: specific roles for Adelta- and C-nociceptors. Experimental Physiology. 87: 281-6. PMID 11856975 DOI: 10.1113/eph8702356  1
2002 Lumb BM, Parry DM, Semenenko FM, McMullan S, Simpson DA. C-nociceptor activation of hypothalamic neurones and the columnar organisation of their projections to the periaqueductal grey in the rat. Experimental Physiology. 87: 123-8. PMID 11856957 DOI: 10.1113/eph8702348  1
2002 Parry DM, Semenenko FM, Conley RK, Lumb BM. Noxious somatic inputs to hypothalamic-midbrain projection neurones: a comparison of the columnar organisation of somatic and visceral inputs to the periaqueductal grey in the rat. Experimental Physiology. 87: 117-22. PMID 11856956 DOI: 10.1113/eph8702347  1
2002 Lumb BM. Physiological society symposium nociceptors as homeostatic afferents: Central processing Experimental Physiology. 87: 237-238.  1
2000 Hudson PM, Semenenko FM, Lumb BM. Inhibitory effects evoked from the rostral ventrolateral medulla are selective for the nociceptive responses of spinal dorsal horn neurons. Neuroscience. 99: 541-7. PMID 11029545 DOI: 10.1016/S0306-4522(00)00210-4  1
2000 Snowball RK, Semenenko FM, Lumb BM. Visceral inputs to neurons in the anterior hypothalamus including those that project to the periaqueductal gray: a functional anatomical and electrophysiological study. Neuroscience. 99: 351-61. PMID 10938441 DOI: 10.1016/S0306-4522(00)00203-7  1
2000 Lovick TA, Parry DM, Stezhka VV, Lumb BM. Serotonergic transmission in the periaqueductal gray matter in relation to aversive behaviour: morphological evidence for direct modulatory effects on identified output neurons. Neuroscience. 95: 763-72. PMID 10670443 DOI: 10.1016/S0306-4522(99)00480-7  1
2000 Lumb B, Murphy D, Paton JFR. Taking integrative physiology into the new millennium: Preface Experimental Physiology. 85: 733.  1
1999 Semenenko FM, Lumb BM. Excitatory projections from the anterior hypothalamus to periaqueductal gray neurons that project to the medulla: a functional anatomical study. Neuroscience. 94: 163-74. PMID 10613506 DOI: 10.1016/S0306-4522(99)00317-6  1
1997 Snowball RK, Dampney RA, Lumb BM. Responses of neurones in the medullary raphe nuclei to inputs from visceral nociceptors and the ventrolateral periaqueductal grey in the rat. Experimental Physiology. 82: 485-500. PMID 9179568  1
1997 Waters AJ, Lumb BM. Inhibitory effects evoked from both the lateral and ventrolateral periaqueductal grey are selective for the nociceptive responses of rat dorsal horn neurones. Brain Research. 752: 239-49. PMID 9106463 DOI: 10.1016/S0006-8993(96)01462-X  1
1996 Hudson PM, Lumb BM. Neurones in the midbrain periaqueductal grey send collateral projections to nucleus raphe magnus and the rostral ventrolateral medulla in the rat. Brain Research. 733: 138-41. PMID 8891260 DOI: 10.1016/S0006-8993(96)00784-6  1
1996 Parry DM, Johns N, Semenenko FM, Snowball RK, Hudson PM, Lumb BM. Glutamatergic projections from the rostral hypothalamus to the periaqueductal grey. Neuroreport. 7: 1536-40. PMID 8856715  1
1994 Semenenko FM, Lumb BM, Lovick TA, Semenenka FM. Projections from nucleus raphe obscurus to the periaqueductal grey matter in the rat. Neuroscience Letters. 170: 9-12. PMID 7999147 DOI: 10.1016/0304-3940(94)90226-7  1
1994 Semenenko FM, Williams CJ, Lumb BM. Enkephalinergic rostral hypothalamic neurones do not project to the intermediate PAG in the rat. Neuroreport. 5: 2613-6. PMID 7696615  1
1993 Lumb BM, Lovick TA. The rostral hypothalamus: an area for the integration of autonomic and sensory responsiveness. Journal of Neurophysiology. 70: 1570-7. PMID 8283214  1
1993 Hudson PM, Semenenko FM, Lumb BM. Projections from the rostral hypothalamus to the ventral medulla in the rat Journal of Physiology. 473: 120P.  1
1993 Semenenko FM, Lumb BM, Lovick TA. Projections from nucleus raphe obscurus to the dorsolateral/lateral and ventrolateral longitudinal columns of the PAG in the rat Journal of Physiology. 473: 118P.  1
1992 Snow PJ, Lumb BM, Cervero F. The representation of prolonged and intense, noxious somatic and visceral stimuli in the ventrolateral orbital cortex of the cat. Pain. 48: 89-99. PMID 1738579 DOI: 10.1016/0304-3959(92)90135-X  1
1992 Semenenko FM, Lumb BM. Projections of anterior hypothalamic neurones to the dorsal and ventral periaqueductal grey in the rat. Brain Research. 582: 237-45. PMID 1393546 DOI: 10.1016/0006-8993(92)90139-Z  1
1990 Lumb BM. Hypothalamic influences on viscero-somatic neurones in the lower thoracic spinal cord of the anaesthetized rat. The Journal of Physiology. 424: 427-44. PMID 2167974  1
1990 Lovick TA, Lumb BM. Association between inhibition of a noxious viscerosomatic reflex and cardiovascular changes evoked by stimulation in the rostral hypothalamus in anaesthetized rats Journal of Physiology. 425: 33P.  1
1989 Lumb BM, Cervero F. Modulation of a viscerosomatic reflex by electrical and chemical stimulation of hypothalamic structures in the rat. Brain Research. 500: 400-4. PMID 2605507 DOI: 10.1016/0006-8993(89)90339-9  1
1988 Cervero F, Lumb BM. Bilateral inputs and supraspinal control of viscerosomatic neurones in the lower thoracic spinal cord of the cat. The Journal of Physiology. 403: 221-37. PMID 3253422  1
1987 Lumb BM, Morrison JF. An excitatory influence of dorsolateral pontine structures on urinary bladder motility in the rat. Brain Research. 435: 363-6. PMID 3427465 DOI: 10.1016/0006-8993(87)91626-X  1
1986 Lumb BM. Brainstem control of visceral afferent pathways in the spinal cord. Progress in Brain Research. 67: 279-93. PMID 3823477 DOI: 10.1016/S0079-6123(08)62768-5  1
1986 Tattersall JE, Cervero F, Lumb BM. Viscerosomatic neurons in the lower thoracic spinal cord of the cat: excitations and inhibitions evoked by splanchnic and somatic nerve volleys and by stimulation of brain stem nuclei. Journal of Neurophysiology. 56: 1411-23. PMID 3794775  1
1986 Tattersall JE, Cervero F, Lumb BM. Effects of reversible spinalization on the visceral input to viscerosomatic neurons in the lower thoracic spinal cord of the cat. Journal of Neurophysiology. 56: 785-96. PMID 3783220  1
1986 Lumb BM, Morrison JF. Electrophysiological evidence for an excitatory projection from ventromedial forebrain structures on to raphe- and reticulo-spinal neurones in the rat. Brain Research. 380: 162-6. PMID 3756468 DOI: 10.1016/0006-8993(86)91442-3  1
1986 Gibson SJ, Polak JM, Anand P, Blank MA, Yiangou Y, Su HC, Terenghi G, Katagiri T, Morrison JF, Lumb BM. A VIP/PHI-containing pathway links urinary bladder and sacral spinal cord. Peptides. 7: 205-19. PMID 3529051 DOI: 10.1016/0196-9781(86)90188-9  1
1985 Cervero F, Lumb BM, Tattersall JE. Supraspinal loops that mediate visceral inputs to thoracic spinal cord neurones in the cat: involvement of descending pathways from raphe and reticular formation. Neuroscience Letters. 56: 189-94. PMID 4011055 DOI: 10.1016/0304-3940(85)90127-2  1
1985 Lumb BM, Wolstencroft JH. Electrophysiological studies of a rostral projection from the nucleus raphe magnus to the hypothalamus in the rat and cat. Brain Research. 327: 336-9. PMID 2985179 DOI: 10.1016/0006-8993(85)91531-8  1
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