Donald M. Kuhn - Publications

Affiliations: 
Wayne State University, Detroit, MI, United States 

149 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Perrine SA, Ghoddoussi F, Desai K, Kohler RJ, Eapen AT, Lisieski MJ, Angoa-Perez M, Kuhn DM, Bosse KE, Conti AC, Bissig D, Berkowitz BA. Cocaine-induced locomotor sensitization in rats correlates with nucleus accumbens activity on manganese-enhanced MRI. Nmr in Biomedicine. PMID 26411897 DOI: 10.1002/nbm.3409  1
2015 Angoa-Pérez M, Kuhn DM. Neuroanatomical dichotomy of sexual behaviors in rodents: a special emphasis on brain serotonin. Behavioural Pharmacology. PMID 26110223 DOI: 10.1097/FBP.0000000000000157  1
2015 Angoa-Pérez M, Herrera-Mundo N, Kane MJ, Sykes CE, Anneken JH, Francescutti DM, Kuhn DM. Brain serotonin signaling does not determine sexual preference in male mice. Plos One. 10: e0118603. PMID 25706994 DOI: 10.1371/journal.pone.0118603  1
2015 Anneken JH, Angoa-Pérez M, Kuhn DM. 3,4-Methylenedioxypyrovalerone prevents while methylone enhances methamphetamine-induced damage to dopamine nerve endings: β-ketoamphetamine modulation of neurotoxicity by the dopamine transporter. Journal of Neurochemistry. 133: 211-22. PMID 25626880 DOI: 10.1111/jnc.13048  1
2015 Solarewicz JZ, Angoa-Perez M, Kuhn DM, Mateika JH. The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 308: R10-7. PMID 25394829 DOI: 10.1152/ajpregu.00400.2014  1
2014 Mychasiuk R, Farran A, Angoa-Perez M, Briggs D, Kuhn D, Esser MJ. A novel model of mild traumatic brain injury for juvenile rats. Journal of Visualized Experiments : Jove. PMID 25548960 DOI: 10.3791/51820  1
2014 Angoa-Pérez M, Kane MJ, Briggs DI, Herrera-Mundo N, Sykes CE, Francescutti DM, Kuhn DM. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. Acs Chemical Neuroscience. 5: 908-19. PMID 25089765 DOI: 10.1021/cn500096g  1
2014 Angoa-Pérez M, Kane MJ, Sykes CE, Perrine SA, Church MW, Kuhn DM. Brain serotonin determines maternal behavior and offspring survival. Genes, Brain, and Behavior. 13: 579-91. PMID 25077934 DOI: 10.1111/gbb.12159  1
2014 Angoa-Pérez M, Kane MJ, Briggs DI, Herrera-Mundo N, Viano DC, Kuhn DM. Animal models of sports-related head injury: bridging the gap between pre-clinical research and clinical reality. Journal of Neurochemistry. 129: 916-31. PMID 24673291 DOI: 10.1111/jnc.12690  1
2014 Hickner S, Hussain N, Angoa-Perez M, Francescutti DM, Kuhn DM, Mateika JH. Ventilatory long-term facilitation is evident after initial and repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin. Journal of Applied Physiology (Bethesda, Md. : 1985). 116: 240-50. PMID 24336886 DOI: 10.1152/japplphysiol.01197.2013  1
2014 Angoa-Pérez M, Kane MJ, Herrera-Mundo N, Francescutti DM, Kuhn DM. Effects of combined treatment with mephedrone and methamphetamine or 3,4-methylenedioxymethamphetamine on serotonin nerve endings of the hippocampus. Life Sciences. 97: 31-6. PMID 23892197 DOI: 10.1016/j.lfs.2013.07.015  1
2013 Angoa-Pérez M, Kane MJ, Briggs DI, Francescutti DM, Kuhn DM. Marble burying and nestlet shredding as tests of repetitive, compulsive-like behaviors in mice. Journal of Visualized Experiments : Jove. 50978. PMID 24429507 DOI: 10.3791/50978  1
2013 Angoa-Pérez M, Kane MJ, Briggs DI, Francescutti DM, Sykes CE, Shah MM, Thomas DM, Kuhn DM. Mephedrone does not damage dopamine nerve endings of the striatum, but enhances the neurotoxicity of methamphetamine, amphetamine, and MDMA. Journal of Neurochemistry. 125: 102-10. PMID 23205838 DOI: 10.1111/jnc.12114  1
2013 Kreipke CW, Kropinski A, Graves J, Tiesma D, Kaufman M, Schafer S, Armstead WM, Dore-Duffy P, Kuhn DM. New frontiers in clinical trials aimed at improving outcome following traumatic brain injury Cerebral Blood Flow, Metabolism, and Head Trauma: the Pathotrajectory of Traumatic Brain Injury. 155-163. DOI: 10.1007/978-1-4614-4148-9_7  1
2013 Kane MJ, Pérez MA, Briggs DI, Viano DC, Kreipke CW, Kuhn DM. Modeling of traumatic brain injury and its implications in studying the pathology of repeated mild impacts to the head Cerebral Blood Flow, Metabolism, and Head Trauma: the Pathotrajectory of Traumatic Brain Injury. 53-73. DOI: 10.1007/978-1-4614-4148-9_3  1
2012 Kane MJ, Angoa-Peréz M, Briggs DI, Sykes CE, Francescutti DM, Rosenberg DR, Kuhn DM. Mice genetically depleted of brain serotonin display social impairments, communication deficits and repetitive behaviors: possible relevance to autism. Plos One. 7: e48975. PMID 23139830 DOI: 10.1371/journal.pone.0048975  1
2012 Jiménez-Trejo F, Tapia-Rodríguez M, Cerbón M, Kuhn DM, Manjarrez-Gutiérrez G, Mendoza-Rodríguez CA, Picazo O. Evidence of 5-HT components in human sperm: implications for protein tyrosine phosphorylation and the physiology of motility. Reproduction (Cambridge, England). 144: 677-85. PMID 23028123 DOI: 10.1530/REP-12-0145  1
2012 Kane MJ, Angoa-Pérez M, Francescutti DM, Sykes CE, Briggs DI, Leung LY, VandeVord PJ, Kuhn DM. Altered gene expression in cultured microglia in response to simulated blast overpressure: possible role of pulse duration. Neuroscience Letters. 522: 47-51. PMID 22698585 DOI: 10.1016/j.neulet.2012.06.012  1
2012 Angoa-Pérez M, Kane MJ, Briggs DI, Sykes CE, Shah MM, Francescutti DM, Rosenberg DR, Thomas DM, Kuhn DM. Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity. Journal of Neurochemistry. 121: 974-84. PMID 22443164 DOI: 10.1111/j.1471-4159.2012.07739.x  1
2012 Angoa-Pérez M, Kane MJ, Francescutti DM, Sykes KE, Shah MM, Mohammed AM, Thomas DM, Kuhn DM. Mephedrone, an abused psychoactive component of 'bath salts' and methamphetamine congener, does not cause neurotoxicity to dopamine nerve endings of the striatum. Journal of Neurochemistry. 120: 1097-107. PMID 22191803 DOI: 10.1111/j.1471-4159.2011.07632.x  1
2012 Kane MJ, Angoa-Pérez M, Briggs DI, Viano DC, Kreipke CW, Kuhn DM. A mouse model of human repetitive mild traumatic brain injury. Journal of Neuroscience Methods. 203: 41-9. PMID 21930157 DOI: 10.1016/j.jneumeth.2011.09.003  1
2011 Kuhn DM, Angoa-Pérez M, Thomas DM. Nucleus accumbens invulnerability to methamphetamine neurotoxicity. Ilar Journal / National Research Council, Institute of Laboratory Animal Resources. 52: 352-65. PMID 23382149 DOI: 10.1093/ilar.52.3.352  1
2011 Kreipke CW, Rafols JA, Reynolds CA, Schafer S, Marinica A, Bedford C, Fronczak M, Kuhn D, Armstead WM. Clazosentan, a novel endothelin A antagonist, improves cerebral blood flow and behavior after traumatic brain injury. Neurological Research. 33: 208-13. PMID 21801597 DOI: 10.1179/016164111X12881719352570  1
2011 Reynolds CA, Schafer S, Pirooz R, Marinica A, Chbib A, Bedford C, Fronczak M, Rafols JA, Kuhn D, Kreipke CW. Differential effects of endothelin receptor A and B antagonism on behavioral outcome following traumatic brain injury. Neurological Research. 33: 197-200. PMID 21801595 DOI: 10.1179/016164111X12881719352499  1
2011 Kuhn DM, Sykes CE, Geddes TJ, Jaunarajs KL, Bishop C. Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: possible link to serotonin deficits and non-motor symptoms in Parkinson's disease. Journal of Neurochemistry. 116: 426-37. PMID 21105877 DOI: 10.1111/j.1471-4159.2010.07123.x  1
2011 Eskow Jaunarajs KL, Angoa-Perez M, Kuhn DM, Bishop C. Potential mechanisms underlying anxiety and depression in Parkinson's disease: consequences of l-DOPA treatment. Neuroscience and Biobehavioral Reviews. 35: 556-64. PMID 20615430 DOI: 10.1016/j.neubiorev.2010.06.007  1
2010 Perrine SA, Ghoddoussi F, Michaels MS, Hyde EM, Kuhn DM, Galloway MP. MDMA administration decreases serotonin but not N-acetylaspartate in the rat brain. Neurotoxicology. 31: 654-61. PMID 20800616 DOI: 10.1016/j.neuro.2010.08.005  1
2010 Thomas DM, Angoa Pérez M, Francescutti-Verbeem DM, Shah MM, Kuhn DM. The role of endogenous serotonin in methamphetamine-induced neurotoxicity to dopamine nerve endings of the striatum. Journal of Neurochemistry. 115: 595-605. PMID 20722968 DOI: 10.1111/j.1471-4159.2010.06950.x  1
2010 Angoa-Pérez M, Kreipke CW, Thomas DM, Van Shura KE, Lyman M, McDonough JH, Kuhn DM. Soman increases neuronal COX-2 levels: possible link between seizures and protracted neuronal damage. Neurotoxicology. 31: 738-46. PMID 20600289 DOI: 10.1016/j.neuro.2010.06.007  1
2010 Opreanu RC, Kuhn D, Basson MD. Influence of alcohol on mortality in traumatic brain injury. Journal of the American College of Surgeons. 210: 997-1007. PMID 20510810 DOI: 10.1016/j.jamcollsurg.2010.01.036  1
2009 Thomas DM, Francescutti-Verbeem DM, Kuhn DM. Increases in cytoplasmic dopamine compromise the normal resistance of the nucleus accumbens to methamphetamine neurotoxicity. Journal of Neurochemistry. 109: 1745-55. PMID 19457119 DOI: 10.1111/j.1471-4159.2009.06094.x  1
2008 Kuhn DM, Francescutti-Verbeem DM, Thomas DM. Dopamine disposition in the presynaptic process regulates the severity of methamphetamine-induced neurotoxicity. Annals of the New York Academy of Sciences. 1139: 118-26. PMID 18991856 DOI: 10.1196/annals.1432.026  1
2008 Ni W, Geddes TJ, Priestley JR, Szasz T, Kuhn DM, Watts SW. The existence of a local 5-hydroxytryptaminergic system in peripheral arteries. British Journal of Pharmacology. 154: 663-74. PMID 18414394 DOI: 10.1038/bjp.2008.111  1
2008 Thomas DM, Francescutti-Verbeem DM, Kuhn DM. Methamphetamine-induced neurotoxicity and microglial activation are not mediated by fractalkine receptor signaling. Journal of Neurochemistry. 106: 696-705. PMID 18410508 DOI: 10.1111/j.1471-4159.2008.05421.x  1
2008 Linder AE, Ni W, Szasz T, Burnett R, Diaz J, Geddes TJ, Kuhn DM, Watts SW. A serotonergic system in veins: serotonin transporter-independent uptake. The Journal of Pharmacology and Experimental Therapeutics. 325: 714-22. PMID 18322152 DOI: 10.1124/jpet.107.135699  1
2008 Thomas DM, Francescutti-Verbeem DM, Kuhn DM. The newly synthesized pool of dopamine determines the severity of methamphetamine-induced neurotoxicity. Journal of Neurochemistry. 105: 605-16. PMID 18088364 DOI: 10.1111/j.1471-4159.2007.05155.x  1
2007 Kuhn DM, Sakowski SA, Geddes TJ, Wilkerson C, Haycock JW. Phosphorylation and activation of tryptophan hydroxylase 2: identification of serine-19 as the substrate site for calcium, calmodulin-dependent protein kinase II. Journal of Neurochemistry. 103: 1567-73. PMID 17727633 DOI: 10.1111/j.1471-4159.2007.04855.x  1
2006 Kuhn DM, Francescutti-Verbeem DM, Thomas DM. Dopamine quinones activate microglia and induce a neurotoxic gene expression profile: relationship to methamphetamine-induced nerve ending damage. Annals of the New York Academy of Sciences. 1074: 31-41. PMID 17105901 DOI: 10.1196/annals.1369.003  1
2006 Bishop C, Taylor JL, Kuhn DM, Eskow KL, Park JY, Walker PD. MDMA and fenfluramine reduce L-DOPA-induced dyskinesia via indirect 5-HT1A receptor stimulation. The European Journal of Neuroscience. 23: 2669-76. PMID 16817869 DOI: 10.1111/j.1460-9568.2006.04790.x  1
2006 Sakowski SA, Geddes TJ, Thomas DM, Levi E, Hatfield JS, Kuhn DM. Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies. Brain Research. 1085: 11-8. PMID 16581041 DOI: 10.1016/j.brainres.2006.02.047  1
2006 Sakowski SA, Geddes TJ, Kuhn DM. Mouse tryptophan hydroxylase isoform 2 and the role of proline 447 in enzyme function. Journal of Neurochemistry. 96: 758-65. PMID 16405505 DOI: 10.1111/j.1471-4159.2005.03604.x  1
2006 Thomas DM, Francescutti-Verbeem DM, Kuhn DM. Gene expression profile of activated microglia under conditions associated with dopamine neuronal damage. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 515-7. PMID 16384912 DOI: 10.1096/fj.05-4873fje  1
2005 Sadidi M, Geddes TJ, Kuhn DM. S-thiolation of tyrosine hydroxylase by reactive nitrogen species in the presence of cysteine or glutathione. Antioxidants & Redox Signaling. 7: 863-9. PMID 15998241 DOI: 10.1089/ars.2005.7.863  1
2005 Thomas DM, Kuhn DM. MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity. Brain Research. 1050: 190-8. PMID 15987631 DOI: 10.1016/j.brainres.2005.05.049  1
2005 Thomas DM, Kuhn DM. Cyclooxygenase-2 is an obligatory factor in methamphetamine-induced neurotoxicity. The Journal of Pharmacology and Experimental Therapeutics. 313: 870-6. PMID 15718289 DOI: 10.1124/jpet.104.080242  1
2005 Thomas DM, Kuhn DM. Attenuated microglial activation mediates tolerance to the neurotoxic effects of methamphetamine. Journal of Neurochemistry. 92: 790-7. PMID 15686480 DOI: 10.1111/j.1471-4159.2004.02906.x  1
2004 Thomas DM, Dowgiert J, Geddes TJ, Francescutti-Verbeem D, Liu X, Kuhn DM. Microglial activation is a pharmacologically specific marker for the neurotoxic amphetamines. Neuroscience Letters. 367: 349-54. PMID 15337264 DOI: 10.1016/j.neulet.2004.06.065  1
2004 Thomas DM, Walker PD, Benjamins JA, Geddes TJ, Kuhn DM. Methamphetamine neurotoxicity in dopamine nerve endings of the striatum is associated with microglial activation. The Journal of Pharmacology and Experimental Therapeutics. 311: 1-7. PMID 15163680 DOI: 10.1124/jpet.104.070961  1
2004 Kuhn DM, Sakowski SA, Sadidi M, Geddes TJ. Nitrotyrosine as a marker for peroxynitrite-induced neurotoxicity: the beginning or the end of the end of dopamine neurons? Journal of Neurochemistry. 89: 529-36. PMID 15086510 DOI: 10.1111/j.1471-4159.2004.02346.x  1
2004 Albertson DN, Pruetz B, Schmidt CJ, Kuhn DM, Kapatos G, Bannon MJ. Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. Journal of Neurochemistry. 88: 1211-9. PMID 15009677 DOI: 10.1046/j.1471-4159.2003.02247.x  1
2004 Thomas DM, Francescutti-Verbeem DM, Liu X, Kuhn DM. Identification of differentially regulated transcripts in mouse striatum following methamphetamine treatment--an oligonucleotide microarray approach. Journal of Neurochemistry. 88: 380-93. PMID 14690526  1
2003 Kuhn DM, Geddes TJ. Tetrahydrobiopterin prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide. Molecular Pharmacology. 64: 946-53. PMID 14500751 DOI: 10.1124/mol.64.4.946  1
2003 Park S, Geddes TJ, Javitch JA, Kuhn DM. Dopamine prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide: is nitrotyrosine formation an early step in dopamine neuronal damage? The Journal of Biological Chemistry. 278: 28736-42. PMID 12771134 DOI: 10.1074/jbc.M304362200  1
2003 Borges CR, Kuhn DM, Watson JT. Mass mapping sites of nitration in tyrosine hydroxylase: random vs selective nitration of three tyrosine residues. Chemical Research in Toxicology. 16: 536-40. PMID 12703971 DOI: 10.1021/tx0256681  1
2002 Borges CR, Geddes T, Watson JT, Kuhn DM. Dopamine biosynthesis is regulated by S-glutathionylation. Potential mechanism of tyrosine hydroxylast inhibition during oxidative stress. The Journal of Biological Chemistry. 277: 48295-302. PMID 12376535 DOI: 10.1074/jbc.M209042200  1
2002 Park SU, Ferrer JV, Javitch JA, Kuhn DM. Peroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: potential mechanism of neurotoxicity in dopamine neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4399-405. PMID 12040046  1
2002 Kuhn DM, Geddes TJ. Reduced nicotinamide nucleotides prevent nitration of tyrosine hydroxylase by peroxynitrite. Brain Research. 933: 85-9. PMID 11929639 DOI: 10.1016/S0006-8993(02)02307-7  1
2002 Kuhn DM, Sadidi M, Liu X, Kreipke C, Geddes T, Borges C, Watson JT. Peroxynitrite-induced nitration of tyrosine hydroxylase: identification of tyrosines 423, 428, and 432 as sites of modification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry and tyrosine-scanning mutagenesis. The Journal of Biological Chemistry. 277: 14336-42. PMID 11834745 DOI: 10.1074/jbc.M200290200  1
2001 Anastasiadis PZ, Jiang H, Bezin L, Kuhn DM, Levine RA. Tetrahydrobiopterin enhances apoptotic PC12 cell death following withdrawal of trophic support. The Journal of Biological Chemistry. 276: 9050-8. PMID 11124941 DOI: 10.1074/jbc.M006570200  1
2000 Kuhn DM, Geddes TJ. Molecular footprints of neurotoxic amphetamine action. Annals of the New York Academy of Sciences. 914: 92-103. PMID 11085312  1
1999 Kuhn DM. Tryptophan hydroxylase regulation. Drug-induced modifications that alter serotonin neuronal function. Advances in Experimental Medicine and Biology. 467: 19-27. PMID 10721034  1
1999 Kuhn DM, Arthur RE. L-DOPA-quinone inactivates tryptophan hydroxylase and converts the enzyme to a redox-cycling quinoprotein. Brain Research. Molecular Brain Research. 73: 78-84. PMID 10581400 DOI: 10.1016/S0169-328X(99)00238-7  1
1999 Kuhn DM, Aretha CW, Geddes TJ. Peroxynitrite inactivation of tyrosine hydroxylase: mediation by sulfhydryl oxidation, not tyrosine nitration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10289-94. PMID 10575026  1
1999 Kuhn DM, Geddes TJ. Peroxynitrite inactivates tryptophan hydroxylase via sulfhydryl oxidation. Coincident nitration of enzyme tyrosyl residues has minimal impact on catalytic activity. The Journal of Biological Chemistry. 274: 29726-32. PMID 10514446 DOI: 10.1074/jbc.274.42.29726  1
1999 Kuhn DM, Arthur RE, Thomas DM, Elferink LA. Tyrosine hydroxylase is inactivated by catechol-quinones and converted to a redox-cycling quinoprotein: possible relevance to Parkinson's disease. Journal of Neurochemistry. 73: 1309-17. PMID 10461926 DOI: 10.1046/j.1471-4159.1999.0731309.x  1
1998 Kuhn DM, Arthur R. Dopamine inactivates tryptophan hydroxylase and forms a redox-cycling quinoprotein: possible endogenous toxin to serotonin neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 7111-7. PMID 9736634  1
1997 Anastasiadis PZ, Bezin L, Imerman BA, Kuhn DM, Louie MC, Levine RA. Tetrahydrobiopterin as a mediator of PC12 cell proliferation induced by EGF and NGF. The European Journal of Neuroscience. 9: 1831-7. PMID 9383205 DOI: 10.1111/j.1460-9568.1997.tb00749.x  1
1997 Kuhn DM, Arthur R. Molecular mechanism of the inactivation of tryptophan hydroxylase by nitric oxide: attack on critical sulfhydryls that spare the enzyme iron center. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 7245-51. PMID 9295371  1
1997 Kuhn DM, Arthur R, States JC. Phosphorylation and activation of brain tryptophan hydroxylase: identification of serine-58 as a substrate site for protein kinase A. Journal of Neurochemistry. 68: 2220-3. PMID 9109552  1
1997 Kuhn DM, Arthur RE. Inactivation of tryptophan hydroxylase by nitric oxide: enhancement by tetrahydrobiopterin. Journal of Neurochemistry. 68: 1495-502. PMID 9084419  1
1996 D'Sa C, Arthur R, Jennings I, Cotton RG, Kuhn DM. Tryptophan hydroxylase: purification by affinity chromatography on calmodulin-sepharose. Journal of Neuroscience Methods. 69: 149-53. PMID 8946317 DOI: 10.1016/S0165-0270(96)00034-9  1
1996 Kuhn DM, Arthur RE. Inactivation of brain tryptophan hydroxylase by nitric oxide. Journal of Neurochemistry. 67: 1072-7. PMID 8752114  1
1996 D'Sa CM, Arthur RE, Kuhn DM. Expression and deletion mutagenesis of tryptophan hydroxylase fusion proteins: delineation of the enzyme catalytic core. Journal of Neurochemistry. 67: 917-26. PMID 8752096  1
1996 D'Sa CM, Arthur RE, States JC, Kuhn DM. Tryptophan hydroxylase: cloning and expression of the rat brain enzyme in mammalian cells. Journal of Neurochemistry. 67: 900-6. PMID 8752094  1
1996 Anastasiadis PZ, Kuhn DM, Blitz J, Imerman BA, Louie MC, Levine RA. Regulation of tyrosine hydroxylase and tetrahydrobiopterin biosynthetic enzymes in PC12 cells by NGF, EGF and IFN-gamma. Brain Research. 713: 125-33. PMID 8724983 DOI: 10.1016/0006-8993(95)01494-2  1
1996 Johansen PA, Jennings I, Cotton RG, Kuhn DM. Phosphorylation and activation of tryptophan hydroxylase by exogenous protein kinase A. Journal of Neurochemistry. 66: 817-23. PMID 8592157  1
1996 Anastasiadis PZ, States JC, Imerman BA, Louie MC, Kuhn DM, Levine RA. Mitogenic effects of tetrahydrobiopterin in PC12 cells. Molecular Pharmacology. 49: 149-55. PMID 8569700  1
1995 Johansen PA, Jennings I, Cotton RG, Kuhn DM. Tryptophan hydroxylase is phosphorylated by protein kinase A. Journal of Neurochemistry. 65: 882-8. PMID 7616249  1
1995 Marron K, Wharton J, Sheppard MN, Fagan D, Royston D, Kuhn DM, de Leval MR, Whitehead BF, Anderson RH, Polak JM. Distribution, morphology, and neurochemistry of endocardial and epicardial nerve terminal arborizations in the human heart. Circulation. 92: 2343-51. PMID 7554220  1
1995 Casasco A, Frattini P, Casasco M, Santagostino G, Springall DR, Kuhn DM, Polak JM. Catecholamines in human dental pulp. A combined immunohistochemical and chromatographic study. European Journal of Histochemistry : Ejh. 39: 133-40. PMID 7549016  1
1995 Anastasiadis PZ, Imerman BA, Louie MC, Kuhn DM, Levine RA. Mitogenic Effects of Tetrahydrobiopterin: Involvement of Catecholamine and Nitric Oxide Synthesis Pteridines. 6: 132-134. DOI: 10.1515/pteridines.1995.6.3.132  1
1994 Berresheim U, Kuhn DM. Dephosphorylation of tyrosine hydroxylase by brain protein phosphatases: a predominant role for type 2A. Brain Research. 637: 273-6. PMID 7910102 DOI: 10.1016/0006-8993(94)91244-0  1
1994 Anastasiadis PZ, Kuhn DM, Levine RA. Tetrahydrobiopterin uptake into rat brain synaptosomes, cultured PC12 cells, and rat striatum. Brain Research. 665: 77-84. PMID 7882022 DOI: 10.1016/0006-8993(94)91154-1  1
1993 Anastasiadis PZ, States JC, Kuhn DM, Levine RA. Co-induction of tetrahydrobiopterin (BH4) levels and tyrosine hydroxylase activity in cultured PC12 cells. Advances in Experimental Medicine and Biology. 338: 227-30. PMID 7905696  1
1993 Levine RA, States JC, Anastasiadis PZ, Kuhn DM. Cloning and characterization of genes encoding tetrahydrobiopterin biosynthetic enzymes. Advances in Experimental Medicine and Biology. 338: 139-45. PMID 7905695  1
1993 Gordon L, Polak JM, Moscoso GJ, Smith A, Kuhn DM, Wharton J. Development of the peptidergic innervation of human heart. Journal of Anatomy. 183: 131-40. PMID 7505778  1
1992 Wolf WA, Kuhn DM. Role of essential sulfhydryl groups in drug interactions at the neuronal 5-HT transporter. Differences between amphetamines and 5-HT uptake inhibitors. The Journal of Biological Chemistry. 267: 20820-5. PMID 1400397  1
1992 Johansen PA, Jennings I, Cotton RG, Kuhn DM. Immobilization of tryptophan hydroxylase by immune adsorption: a method to study regulation of catalytic activity. Brain Research Bulletin. 29: 949-53. PMID 1335352 DOI: 10.1016/0361-9230(92)90170-3  1
1991 Wolf WA, Kuhn DM. Cocaine and serotonin neurochemistry. Neurochemistry International. 18: 33-8. PMID 20504672 DOI: 10.1016/0197-0186(91)90032-9  1
1991 Johansen PA, Wolf WA, Kuhn DM. Inhibition of tryptophan hydroxylase by benserazide and other catechols. Biochemical Pharmacology. 41: 625-8. PMID 1997008 DOI: 10.1016/0006-2952(91)90636-J  1
1991 Karanth SS, Springall DR, Kuhn DM, Levene MM, Polak JM. An immunocytochemical study of cutaneous innervation and the distribution of neuropeptides and protein gene product 9.5 in man and commonly employed laboratory animals. The American Journal of Anatomy. 191: 369-83. PMID 1719791 DOI: 10.1002/aja.1001910404  1
1991 Wolf WA, Ziaja E, Arthur RA, Anastasiadis PZ, Levine RA, Kuhn DM. Effect of tetrahydrobiopterin on serotonin synthesis, release, and metabolism in superfused hippocampal slices. Journal of Neurochemistry. 57: 1191-7. PMID 1716662 DOI: 10.1111/j.1471-4159.1991.tb08279.x  1
1991 Kuhn DM, Johansen P, Jennings I, Cotton RGH. Tryptophan Hydroxylase and Protein Kinase Interactions; Does Phosphorylation Cause Activation? Pteridines. 3: 61-62. DOI: 10.1515/pteridines.1991.3.12.61  1
1991 Wolf WA, Kuhn DM. The 5-HT transporter is an additional site of action for the 5-HT agonists RU 24969 and TFMPP Neurochemistry International. 19: 39-44. DOI: 10.1016/0197-0186(91)90117-V  1
1990 Wolf WA, Anastasiadis PZ, Kuhn DM, Levine RA. Influence of tetrahydrobiopterin on serotonin synthesis, metabolism and release in synaptosomes. Neurochemistry International. 16: 335-40. PMID 20504577 DOI: 10.1016/0197-0186(90)90111-6  1
1990 Wolf WA, Kuhn DM. Modulation of serotonin release. Interactions between the serotonin transporter and autoreceptors. Annals of the New York Academy of Sciences. 604: 505-13. PMID 2171405 DOI: 10.1111/j.1749-6632.1990.tb32016.x  1
1990 Kuhn DM, Arthur R, Yoon H, Sankaran K. Tyrosine hydroxylase in secretory granules from bovine adrenal medulla. Evidence for an integral membrane form. The Journal of Biological Chemistry. 265: 5780-6. PMID 1969407  1
1990 Normile HJ, Jenden DJ, Kuhn DM, Wolf WA, Altman HJ. Effects of combined serotonin depletion and lesions of the nucleus basalis magnocellularis on acquisition of a complex spatial discrimination task in the rat. Brain Research. 536: 245-50. PMID 1707719 DOI: 10.1016/0006-8993(90)90031-6  1
1989 Pennypacker KR, Kuhn DM, Billingsley ML. Changes in expression of tyrosine hydroxylase immunoreactivity in human SMS-KCNR neuroblastoma following retinoic acid or phorbol ester-induced differentiation. Brain Research. Molecular Brain Research. 5: 251-8. PMID 2568572 DOI: 10.1016/0169-328X(89)90059-4  1
1989 Salah RS, Kuhn DM, Galloway MP. Dopamine autoreceptors modulate the phosphorylation of tyrosine hydroxylase in rat striatal slices. Journal of Neurochemistry. 52: 1517-22. PMID 2565375 DOI: 10.1111/j.1471-4159.1989.tb09202.x  1
1988 Kuhn DM, Volknandt W, Stadler H, Zimmermann H. Cholinergic vesicle specific proteoglycan: stability in isolated vesicles and in synaptosomes during induced transmitter release. Journal of Neurochemistry. 50: 11-6. PMID 3121784 DOI: 10.1111/j.1471-4159.1988.tb13223.x  1
1988 Wharton J, Gulbenkian S, Merighi A, Kuhn DM, Jahn R, Taylor KM, Polak JM. Immunohistochemical and ultrastructural localisation of peptide-containing nerves and myocardial cells in the human atrial appendage. Cell and Tissue Research. 254: 155-66. PMID 2973836 DOI: 10.1007/BF00220029  1
1987 Kuhn DM, Billingsley ML. Tyrosine hydroxylase: purification from PC-12 cells, characterization and production of antibodies. Neurochemistry International. 11: 463-75. PMID 20501194 DOI: 10.1016/0197-0186(87)90036-2  1
1987 Dix TA, Kuhn DM, Benkovic SJ. Mechanism of oxygen activation by tyrosine hydroxylase. Biochemistry. 26: 3354-61. PMID 2888478  1
1986 Billingsley ML, Balaban CD, Berresheim U, Kuhn DM. Comparative studies on the distribution of protein-o-carboxylmethyltransferase and tyrosine hydroxylase in rat brain by immunocytochemistry. Neurochemistry International. 8: 255-65. PMID 20493055 DOI: 10.1016/0197-0186(86)90172-5  1
1986 Kuhn DM, Wolf WA, Youdim MB. Serotonin neurochemistry revisited: A new look at some old axioms. Neurochemistry International. 8: 141-54. PMID 20493040 DOI: 10.1016/0197-0186(86)90157-9  1
1986 Wolf WA, Kuhn DM. Uptake and release of tryptophan and serotonin: an HPLC method to study the flux of endogenous 5-hydroxyindoles through synaptosomes. Journal of Neurochemistry. 46: 61-7. PMID 2415683 DOI: 10.1111/j.1471-4159.1986.tb12925.x  1
1985 Billingsley ML, Kim S, Kuhn DM. Immunohistochemical localization of protein-O-carboxylmethyltransferase in rat brain neurons. Neuroscience. 15: 159-71. PMID 3892360 DOI: 10.1016/0306-4522(85)90130-7  1
1985 Wolf WA, Youdim MB, Kuhn DM. Does brain 5-HIAA indicate serotonin release or monoamine oxidase activity? European Journal of Pharmacology. 109: 381-7. PMID 2580723 DOI: 10.1016/0014-2999(85)90399-1  1
1985 Kuhn DM, Wolf WA, Youdim MB. 5-Hydroxytryptamine release in vivo from a cytoplasmic pool: studies on the 5-HT behavioural syndrome in reserpinized rats. British Journal of Pharmacology. 84: 121-9. PMID 2579697  1
1984 Wolf WA, Kuhn DM. Effects of L-tryptophan on blood pressure in normotensive and hypertensive rats. The Journal of Pharmacology and Experimental Therapeutics. 230: 324-9. PMID 6205137  1
1984 Wolf WA, Kuhn DM. Antihypertensive effects of L-tryptophan are not mediated by brain serotonin. Brain Research. 295: 356-9. PMID 6201230 DOI: 10.1016/0006-8993(84)90985-5  1
1984 Levine RA, Pollard HB, Kuhn DM. A rapid and simplified assay method for tyrosine hydroxylase. Analytical Biochemistry. 143: 205-8. PMID 6152135 DOI: 10.1016/0003-2697(84)90577-3  1
1984 Wolf WA, Youdim MBH, Kuhn DM. Functional serotonin release occurs from A small, nonvesicular pool Federation Proceedings. 43: no. 748.  1
1983 Juskevich JC, Kuhn DM, Lovenberg W. Phosphorylation of brain cytosol proteins. Effects of phospholipids and calmodulin. The Journal of Biological Chemistry. 258: 1950-3. PMID 6822544  1
1983 Wolf WA, Kuhn DM. Simultaneous determination of 5-hydroxytryptamine, its amino acid precursors and acid metabolite in discrete brain regions by high-performance liquid chromatography with fluorescence detection. Journal of Chromatography. 275: 1-9. PMID 6192135 DOI: 10.1016/S0378-4347(00)84338-8  1
1983 Kuhn DM, Lovenberg W. Inactivation of tyrosine hydroxylase by reduced pterins. Biochemical and Biophysical Research Communications. 117: 894-900. PMID 6141794 DOI: 10.1016/0006-291X(83)91680-7  1
1982 Juskevich JC, Kuhn DM, Lovenberg W. Calcium enhanced inactivation of calmodulin dependent protein kinase from synaptosomes. Biochemical and Biophysical Research Communications. 108: 24-30. PMID 7150284 DOI: 10.1016/0006-291X(82)91826-5  1
1982 Lovenberg W, Kuhn DM. Substrate regulation of serotonin synthesis. Advances in Biochemical Psychopharmacology. 34: 73-83. PMID 6753516  1
1982 Kuhn DM, Lovenberg W. Role of calmodulin in the activation of tryptophan hydroxylase. Federation Proceedings. 41: 2258-64. PMID 6122608  1
1982 Kuhn DM. Calcium-dependent phosphorylation and the regulation of serotonin synthesis Psychopharmacology Bulletin. 18: 161-165.  1
1981 Wolf WA, Kuhn DM, Lovenberg W. Pressor effects of dorsal raphe stimulation and intrahypothalamic application of serotonin in the spontaneously hypertensive rat. Brain Research. 208: 192-7. PMID 7470921 DOI: 10.1016/0006-8993(81)90631-4  1
1981 Kuhn DM, Ruskin B, Lovenberg W. Studies on the oxygen sensitivity of tryptophan hydroxylase. Advances in Experimental Medicine and Biology. 133: 253-63. PMID 7315604  1
1981 Wolf WA, Kuhn DM, Lovenberg W. Blood pressure responses to local application of serotonergic agents in the nucleus tractus solitarii. European Journal of Pharmacology. 69: 291-9. PMID 6971228  0.48
1981 Zabrenetzky V, Kuhn DM, Lovenberg W. Evidence of a calmodulin-like subunit of pro-protein kinase C from fluphenazine-sepharose affinity chromatography Federation Proceedings. 40: 378.  1
1980 Kuhn DM, Ruskin B, Lovenberg W. Tryptophan hydroxylase. The role of oxygen, iron, and sulfhydryl groups as determinants of stability and catalytic activity. The Journal of Biological Chemistry. 255: 4137-43. PMID 7372670  1
1980 Kuhn DM, Meyer MA, Lovenberg W. Comparisons of tryptophan hydroxylase from a malignant murine mast cell tumor and rat mesencephalic tegmentum. Archives of Biochemistry and Biophysics. 199: 355-61. PMID 6767445 DOI: 10.1016/0003-9861(80)90291-X  1
1980 Kuhn DM, Wolf WA, Lovenberg W. Review of the role of the central serotonergic neuronal system in blood pressure regulation. Hypertension. 2: 243-55. PMID 6446522  1
1980 Kuhn DM, O'Callaghan JP, Lovenberg W. The role of calmodulin in the activation of tryptophan hydroxylase by phosphorylating conditions. Annals of the New York Academy of Sciences. 356: 399. PMID 6112952 DOI: 10.1111/j.1749-6632.1980.tb29645.x  1
1980 Kuhn DM, O'Callaghan JP, Juskevich J, Lovenberg W. Activation of brain tryptophan hydroxylase by ATP-MG2+: dependence on calmodulin. Proceedings of the National Academy of Sciences of the United States of America. 77: 4688-91. PMID 6107909  1
1980 Kuhn DM, Wolf WA, Lovenberg W. Pressor effects of electrical stimulation of the dorsal and median raphe nuclei in anesthetized rats. The Journal of Pharmacology and Experimental Therapeutics. 214: 403-9. PMID 6104727  1
1979 Kuhn DM, Meyer MA, Lovenberg W. Activation of rat brain tryptophan hydroxylase by polyelectrolytes. Biochemical Pharmacology. 28: 3255-60. PMID 526331 DOI: 10.1016/0006-2952(79)90118-7  1
1979 Kuhn DM, Rosenberg RC, Lovenberg W. Determination of some molecular parameters of tryptophan hydroxylase from rat midbrain and murine mast cell. Journal of Neurochemistry. 33: 15-21. PMID 458447 DOI: 10.1111/j.1471-4159.1979.tb11700.x  1
1979 Sankaran K, Kuhn DM, Lovenberg W. Cyclic AMP specific, calcium independent phosphodiesterase from a malignant murine mast cell tumor. Biochemical and Biophysical Research Communications. 89: 793-9. PMID 226093 DOI: 10.1016/0006-291X(79)91848-5  1
1979 Levine RA, Kuhn DM, Lovenberg W. The regional distribution of hydroxylase cofactor in rat brain. Journal of Neurochemistry. 32: 1575-8. PMID 35590 DOI: 10.1111/j.1471-4159.1979.tb11101.x  1
1979 White FJ, Appel JB, Kuhn DM. Discriminative stimulus properties of quipazine: direct serotonergic mediation. Neuropharmacology. 18: 143-51. PMID 34803 DOI: 10.1016/0028-3908(79)90054-6  1
1978 Shah NS, Kuhn DM. Regional localization of methaqualone in rat brain. Research Communications in Chemical Pathology and Pharmacology. 22: 593-6. PMID 734237  1
1978 Kuhn DM, Shah NS. Subcellular localization of [14C]methaqualone in mouse brain: effects of hepatic microsomal enzyme inhibition. Toxicology and Applied Pharmacology. 46: 109-16. PMID 725937 DOI: 10.1016/0041-008X(78)90141-2  1
1978 Lovenberg W, Kuhn DM. Role of hydroxylase cofactor in serotonin biosynthesis. Psychopharmacology Bulletin. 14: 44-6. PMID 704758  1
1978 Kuhn DM, Vogel RL, Lovenberg W. Calcium-dependent activation of tryptophan hydroxylase by ATP and magnesium. Biochemical and Biophysical Research Communications. 82: 759-66. PMID 666869 DOI: 10.1016/0006-291X(78)90940-3  1
1978 Kuhn DM, White FJ, Appel JB. The discriminative stimulus properties of LSD: mechanisms of action. Neuropharmacology. 17: 257-63. PMID 652138 DOI: 10.1016/0028-3908(78)90109-0  1
1978 Christoph GR, Kuhn DM, Jacobs BL. Dopamine agonist pretreatment alters LSD's electrophysiological action from dopamine agonists to antagonist. Life Sciences. 23: 2099-110. PMID 31539 DOI: 10.1016/0024-3205(78)90183-2  1
1978 Appel JB, White FJ, Kuhn DM. The use of drugs as discriminative stimuli in behavioral pharmacodynamics Psychopharmacology. 58: 3.  1
1977 Christoph GR, Kuhn DM, Jacobs BL. Electrophysiological evidence for a dopaminergic action of LSD: depression of unit activity in the substantia nigra of the rat. Life Sciences. 21: 1585-96. PMID 202830 DOI: 10.1016/0024-3205(77)90235-1  1
1976 Kuhn DM, Greenberg I, Appel JB. Stimulus properties of the narcotic antagonist pentazocine: similarity to morphine and antagonism by naloxone. The Journal of Pharmacology and Experimental Therapeutics. 196: 121-7. PMID 1246006  1
1976 Kuhn DM, White FJ, Appel JB. Discriminable stimuli produced by hallucinogens. Psychopharmacology Communications. 2: 345-8. PMID 996285  1
1975 Greenberg I, Kuhn DM, Appel JB. Behaviorally induced sensitivity to the discriminable properties of LSD. Psychopharmacologia. 43: 229-32. PMID 1187955 DOI: 10.1007/BF00429255  1
1974 Kuhn DM, Appel JB, Greenberg I. An analysis of some discriminative properties of d-amphetamine. Psychopharmacologia. 39: 57-66. PMID 4138622 DOI: 10.1007/BF00421458  1
1974 Kuhn DM, Greenberg I, Appel JB. Differential effects on lever choice and response rate produced by d-amphetamine Bulletin of the Psychonomic Society. 3: 119-120. DOI: 10.3758/BF03333413  1
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