Donald M. Kuhn - Publications

Affiliations: 
Wayne State University, Detroit, MI, United States 

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Angoa-Pérez M, Zagorac B, Anneken JH, Briggs DI, Winters AD, Greenberg JM, Ahmad M, Theis KR, Kuhn DM. Repetitive, mild traumatic brain injury results in a progressive white matter pathology, cognitive deterioration, and a transient gut microbiota dysbiosis. Scientific Reports. 10: 8949. PMID 32488168 DOI: 10.1038/S41598-020-65972-4  0.758
2018 Anneken JH, Angoa-Perez M, Sati GC, Crich D, Kuhn DM. Dissociation between hypothermia and neurotoxicity caused by mephedrone and methcathinone in TPH2 knockout mice. Psychopharmacology. PMID 30074064 DOI: 10.1007/S00213-018-4991-8  0.31
2017 Anneken JH, Angoa-Perez M, Sati GC, Crich D, Kuhn DM. Assessing the role of dopamine in the differential neurotoxicity patterns of methamphetamine, mephedrone, methcathinone and 4-methylmethamphetamine. Neuropharmacology. PMID 28851615 DOI: 10.1016/J.Neuropharm.2017.08.033  0.306
2016 Acabchuk R, Briggs DI, Angoa-Pérez M, Powers M, Wolferz R, Soloway M, Stern M, Talbot LR, Kuhn DM, Conover JC. Repeated mild traumatic brain injury causes focal response in lateral septum and hippocampus. Concussion. 1. PMID 28078102  0.746
2016 Anneken JH, Angoa-Perez M, Sati GC, Crich D, Kuhn DM. Dissecting the influence of two structural substituents on the differential neurotoxic effects of methamphetamine and mephedrone on dopamine nerve endings with the use of 4-methylmethamphetamine and methcathinone. The Journal of Pharmacology and Experimental Therapeutics. PMID 28039330 DOI: 10.1124/Jpet.116.237768  0.322
2016 Briggs DI, Angoa-Pérez M, Kuhn DM. Prolonged Repetitive Head Trauma Induces a Singular Chronic Traumatic Encephalopathy-Like Pathology in White Matter Despite Transient Behavioral Abnormalities. The American Journal of Pathology. PMID 27662795 DOI: 10.1016/J.Ajpath.2016.07.013  0.76
2015 Anneken JH, Angoa-Pérez M, Kuhn DM. 3,4-Methylenedioxypyrovalerone prevents while methylone enhances methamphetamine-induced damage to dopamine nerve endings: β-ketoamphetamine modulation of neurotoxicity by the dopamine transporter. Journal of Neurochemistry. 133: 211-22. PMID 25626880 DOI: 10.1111/Jnc.13048  0.328
2014 Mychasiuk R, Farran A, Angoa-Perez M, Briggs D, Kuhn D, Esser MJ. A novel model of mild traumatic brain injury for juvenile rats. Journal of Visualized Experiments : Jove. PMID 25548960 DOI: 10.3791/51820  0.755
2014 Angoa-Pérez M, Kane MJ, Briggs DI, Herrera-Mundo N, Sykes CE, Francescutti DM, Kuhn DM. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. Acs Chemical Neuroscience. 5: 908-19. PMID 25089765 DOI: 10.1021/Cn500096G  0.727
2014 Angoa-Pérez M, Kane MJ, Briggs DI, Herrera-Mundo N, Viano DC, Kuhn DM. Animal models of sports-related head injury: bridging the gap between pre-clinical research and clinical reality. Journal of Neurochemistry. 129: 916-31. PMID 24673291 DOI: 10.1111/Jnc.12690  0.752
2014 Angoa-Pérez M, Kane MJ, Herrera-Mundo N, Francescutti DM, Kuhn DM. Effects of combined treatment with mephedrone and methamphetamine or 3,4-methylenedioxymethamphetamine on serotonin nerve endings of the hippocampus. Life Sciences. 97: 31-6. PMID 23892197 DOI: 10.1016/J.Lfs.2013.07.015  0.301
2013 Angoa-Pérez M, Kane MJ, Briggs DI, Francescutti DM, Kuhn DM. Marble burying and nestlet shredding as tests of repetitive, compulsive-like behaviors in mice. Journal of Visualized Experiments : Jove. 50978. PMID 24429507 DOI: 10.3791/50978  0.738
2013 Angoa-Pérez M, Kane MJ, Briggs DI, Francescutti DM, Sykes CE, Shah MM, Thomas DM, Kuhn DM. Mephedrone does not damage dopamine nerve endings of the striatum, but enhances the neurotoxicity of methamphetamine, amphetamine, and MDMA. Journal of Neurochemistry. 125: 102-10. PMID 23205838 DOI: 10.1111/Jnc.12114  0.745
2013 Kane MJ, Pérez MA, Briggs DI, Viano DC, Kreipke CW, Kuhn DM. Modeling of traumatic brain injury and its implications in studying the pathology of repeated mild impacts to the head Cerebral Blood Flow, Metabolism, and Head Trauma: the Pathotrajectory of Traumatic Brain Injury. 53-73. DOI: 10.1007/978-1-4614-4148-9_3  0.748
2012 Kane MJ, Angoa-Peréz M, Briggs DI, Sykes CE, Francescutti DM, Rosenberg DR, Kuhn DM. Mice genetically depleted of brain serotonin display social impairments, communication deficits and repetitive behaviors: possible relevance to autism. Plos One. 7: e48975. PMID 23139830 DOI: 10.1371/Journal.Pone.0048975  0.749
2012 Kane MJ, Angoa-Pérez M, Francescutti DM, Sykes CE, Briggs DI, Leung LY, VandeVord PJ, Kuhn DM. Altered gene expression in cultured microglia in response to simulated blast overpressure: possible role of pulse duration. Neuroscience Letters. 522: 47-51. PMID 22698585 DOI: 10.1016/J.Neulet.2012.06.012  0.746
2012 Angoa-Pérez M, Kane MJ, Briggs DI, Sykes CE, Shah MM, Francescutti DM, Rosenberg DR, Thomas DM, Kuhn DM. Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity. Journal of Neurochemistry. 121: 974-84. PMID 22443164 DOI: 10.1111/J.1471-4159.2012.07739.X  0.748
2012 Angoa-Pérez M, Kane MJ, Francescutti DM, Sykes KE, Shah MM, Mohammed AM, Thomas DM, Kuhn DM. Mephedrone, an abused psychoactive component of 'bath salts' and methamphetamine congener, does not cause neurotoxicity to dopamine nerve endings of the striatum. Journal of Neurochemistry. 120: 1097-107. PMID 22191803 DOI: 10.1111/J.1471-4159.2011.07632.X  0.344
2012 Kane MJ, Angoa-Pérez M, Briggs DI, Viano DC, Kreipke CW, Kuhn DM. A mouse model of human repetitive mild traumatic brain injury. Journal of Neuroscience Methods. 203: 41-9. PMID 21930157 DOI: 10.1016/J.Jneumeth.2011.09.003  0.767
2011 Kreipke CW, Rafols JA, Reynolds CA, Schafer S, Marinica A, Bedford C, Fronczak M, Kuhn D, Armstead WM. Clazosentan, a novel endothelin A antagonist, improves cerebral blood flow and behavior after traumatic brain injury. Neurological Research. 33: 208-13. PMID 21801597 DOI: 10.1179/016164111X12881719352570  0.381
2011 Reynolds CA, Schafer S, Pirooz R, Marinica A, Chbib A, Bedford C, Fronczak M, Rafols JA, Kuhn D, Kreipke CW. Differential effects of endothelin receptor A and B antagonism on behavioral outcome following traumatic brain injury. Neurological Research. 33: 197-200. PMID 21801595 DOI: 10.1179/016164111X12881719352499  0.313
2011 Kuhn DM, Sykes CE, Geddes TJ, Jaunarajs KL, Bishop C. Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: possible link to serotonin deficits and non-motor symptoms in Parkinson's disease. Journal of Neurochemistry. 116: 426-37. PMID 21105877 DOI: 10.1111/J.1471-4159.2010.07123.X  0.314
2010 Thomas DM, Angoa Pérez M, Francescutti-Verbeem DM, Shah MM, Kuhn DM. The role of endogenous serotonin in methamphetamine-induced neurotoxicity to dopamine nerve endings of the striatum. Journal of Neurochemistry. 115: 595-605. PMID 20722968 DOI: 10.1111/J.1471-4159.2010.06950.X  0.367
2009 Thomas DM, Francescutti-Verbeem DM, Kuhn DM. Increases in cytoplasmic dopamine compromise the normal resistance of the nucleus accumbens to methamphetamine neurotoxicity. Journal of Neurochemistry. 109: 1745-55. PMID 19457119 DOI: 10.1111/J.1471-4159.2009.06094.X  0.373
2008 Kuhn DM, Francescutti-Verbeem DM, Thomas DM. Dopamine disposition in the presynaptic process regulates the severity of methamphetamine-induced neurotoxicity. Annals of the New York Academy of Sciences. 1139: 118-26. PMID 18991856 DOI: 10.1196/Annals.1432.026  0.347
2008 Thomas DM, Francescutti-Verbeem DM, Kuhn DM. Methamphetamine-induced neurotoxicity and microglial activation are not mediated by fractalkine receptor signaling. Journal of Neurochemistry. 106: 696-705. PMID 18410508 DOI: 10.1111/J.1471-4159.2008.05421.X  0.369
2008 Thomas DM, Francescutti-Verbeem DM, Kuhn DM. The newly synthesized pool of dopamine determines the severity of methamphetamine-induced neurotoxicity. Journal of Neurochemistry. 105: 605-16. PMID 18088364 DOI: 10.1111/J.1471-4159.2007.05155.X  0.366
2007 Kuhn DM, Sakowski SA, Geddes TJ, Wilkerson C, Haycock JW. Phosphorylation and activation of tryptophan hydroxylase 2: identification of serine-19 as the substrate site for calcium, calmodulin-dependent protein kinase II. Journal of Neurochemistry. 103: 1567-73. PMID 17727633 DOI: 10.1111/J.1471-4159.2007.04855.X  0.66
2006 Kuhn DM, Francescutti-Verbeem DM, Thomas DM. Dopamine quinones activate microglia and induce a neurotoxic gene expression profile: relationship to methamphetamine-induced nerve ending damage. Annals of the New York Academy of Sciences. 1074: 31-41. PMID 17105901 DOI: 10.1196/Annals.1369.003  0.329
2006 Sakowski SA, Geddes TJ, Thomas DM, Levi E, Hatfield JS, Kuhn DM. Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies. Brain Research. 1085: 11-8. PMID 16581041 DOI: 10.1016/J.Brainres.2006.02.047  0.662
2006 Sakowski SA, Geddes TJ, Kuhn DM. Mouse tryptophan hydroxylase isoform 2 and the role of proline 447 in enzyme function. Journal of Neurochemistry. 96: 758-65. PMID 16405505 DOI: 10.1111/J.1471-4159.2005.03604.X  0.675
2006 Thomas DM, Francescutti-Verbeem DM, Kuhn DM. Gene expression profile of activated microglia under conditions associated with dopamine neuronal damage. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 515-7. PMID 16384912 DOI: 10.1096/Fj.05-4873Fje  0.34
2005 Sadidi M, Geddes TJ, Kuhn DM. S-thiolation of tyrosine hydroxylase by reactive nitrogen species in the presence of cysteine or glutathione. Antioxidants & Redox Signaling. 7: 863-9. PMID 15998241 DOI: 10.1089/Ars.2005.7.863  0.751
2005 Thomas DM, Kuhn DM. MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity. Brain Research. 1050: 190-8. PMID 15987631 DOI: 10.1016/J.Brainres.2005.05.049  0.348
2005 Thomas DM, Kuhn DM. Attenuated microglial activation mediates tolerance to the neurotoxic effects of methamphetamine. Journal of Neurochemistry. 92: 790-7. PMID 15686480 DOI: 10.1111/J.1471-4159.2004.02906.X  0.344
2004 Thomas DM, Dowgiert J, Geddes TJ, Francescutti-Verbeem D, Liu X, Kuhn DM. Microglial activation is a pharmacologically specific marker for the neurotoxic amphetamines. Neuroscience Letters. 367: 349-54. PMID 15337264 DOI: 10.1016/J.Neulet.2004.06.065  0.376
2004 Kuhn DM, Sakowski SA, Sadidi M, Geddes TJ. Nitrotyrosine as a marker for peroxynitrite-induced neurotoxicity: the beginning or the end of the end of dopamine neurons? Journal of Neurochemistry. 89: 529-36. PMID 15086510 DOI: 10.1111/J.1471-4159.2004.02346.X  0.733
2004 Thomas DM, Francescutti-Verbeem DM, Liu X, Kuhn DM. Identification of differentially regulated transcripts in mouse striatum following methamphetamine treatment--an oligonucleotide microarray approach. Journal of Neurochemistry. 88: 380-93. PMID 14690526 DOI: 10.1046/J.1471-4159.2003.02182.X  0.313
2003 Kuhn DM, Geddes TJ. Tetrahydrobiopterin prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide. Molecular Pharmacology. 64: 946-53. PMID 14500751 DOI: 10.1124/Mol.64.4.946  0.342
2003 Park S, Geddes TJ, Javitch JA, Kuhn DM. Dopamine prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide: is nitrotyrosine formation an early step in dopamine neuronal damage? The Journal of Biological Chemistry. 278: 28736-42. PMID 12771134 DOI: 10.1074/Jbc.M304362200  0.37
2002 Borges CR, Geddes T, Watson JT, Kuhn DM. Dopamine biosynthesis is regulated by S-glutathionylation. Potential mechanism of tyrosine hydroxylast inhibition during oxidative stress. The Journal of Biological Chemistry. 277: 48295-302. PMID 12376535 DOI: 10.1074/Jbc.M209042200  0.336
2002 Park SU, Ferrer JV, Javitch JA, Kuhn DM. Peroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: potential mechanism of neurotoxicity in dopamine neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4399-405. PMID 12040046 DOI: 10.1523/Jneurosci.22-11-04399.2002  0.341
2002 Kuhn DM, Sadidi M, Liu X, Kreipke C, Geddes T, Borges C, Watson JT. Peroxynitrite-induced nitration of tyrosine hydroxylase: identification of tyrosines 423, 428, and 432 as sites of modification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry and tyrosine-scanning mutagenesis. The Journal of Biological Chemistry. 277: 14336-42. PMID 11834745 DOI: 10.1074/Jbc.M200290200  0.753
2000 Kuhn DM, Geddes TJ. Molecular footprints of neurotoxic amphetamine action. Annals of the New York Academy of Sciences. 914: 92-103. PMID 11085312 DOI: 10.1111/J.1749-6632.2000.Tb05187.X  0.371
1999 Kuhn DM. Tryptophan hydroxylase regulation. Drug-induced modifications that alter serotonin neuronal function. Advances in Experimental Medicine and Biology. 467: 19-27. PMID 10721034 DOI: 10.1007/978-1-4615-4709-9_3  0.364
1999 Kuhn DM, Aretha CW, Geddes TJ. Peroxynitrite inactivation of tyrosine hydroxylase: mediation by sulfhydryl oxidation, not tyrosine nitration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10289-94. PMID 10575026 DOI: 10.1523/Jneurosci.19-23-10289.1999  0.333
1999 Kuhn DM, Arthur RE, Thomas DM, Elferink LA. Tyrosine hydroxylase is inactivated by catechol-quinones and converted to a redox-cycling quinoprotein: possible relevance to Parkinson's disease. Journal of Neurochemistry. 73: 1309-17. PMID 10461926 DOI: 10.1046/J.1471-4159.1999.0731309.X  0.326
1998 Kuhn DM, Arthur R. Dopamine inactivates tryptophan hydroxylase and forms a redox-cycling quinoprotein: possible endogenous toxin to serotonin neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 7111-7. PMID 9736634 DOI: 10.1523/Jneurosci.18-18-07111.1998  0.354
1997 Kuhn DM, Arthur R. Molecular mechanism of the inactivation of tryptophan hydroxylase by nitric oxide: attack on critical sulfhydryls that spare the enzyme iron center. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 7245-51. PMID 9295371 DOI: 10.1523/Jneurosci.17-19-07245.1997  0.311
1996 Kuhn DM, Arthur RE. Inactivation of brain tryptophan hydroxylase by nitric oxide. Journal of Neurochemistry. 67: 1072-7. PMID 8752114 DOI: 10.1046/J.1471-4159.1996.67031072.X  0.314
1996 D'Sa CM, Arthur RE, States JC, Kuhn DM. Tryptophan hydroxylase: cloning and expression of the rat brain enzyme in mammalian cells. Journal of Neurochemistry. 67: 900-6. PMID 8752094 DOI: 10.1046/J.1471-4159.1996.67030900.X  0.33
1996 Johansen PA, Jennings I, Cotton RG, Kuhn DM. Phosphorylation and activation of tryptophan hydroxylase by exogenous protein kinase A. Journal of Neurochemistry. 66: 817-23. PMID 8592157 DOI: 10.1046/J.1471-4159.1996.66020817.X  0.487
1995 Johansen PA, Jennings I, Cotton RG, Kuhn DM. Tryptophan hydroxylase is phosphorylated by protein kinase A. Journal of Neurochemistry. 65: 882-8. PMID 7616249 DOI: 10.1046/J.1471-4159.1995.65020882.X  0.496
1994 Anastasiadis PZ, Kuhn DM, Levine RA. Tetrahydrobiopterin uptake into rat brain synaptosomes, cultured PC12 cells, and rat striatum. Brain Research. 665: 77-84. PMID 7882022 DOI: 10.1016/0006-8993(94)91154-1  0.304
1992 Johansen PA, Jennings I, Cotton RG, Kuhn DM. Immobilization of tryptophan hydroxylase by immune adsorption: a method to study regulation of catalytic activity. Brain Research Bulletin. 29: 949-53. PMID 1335352 DOI: 10.1016/0361-9230(92)90170-3  0.496
1991 Johansen PA, Wolf WA, Kuhn DM. Inhibition of tryptophan hydroxylase by benserazide and other catechols. Biochemical Pharmacology. 41: 625-8. PMID 1997008 DOI: 10.1016/0006-2952(91)90636-J  0.519
1991 Kuhn DM, Johansen P, Jennings I, Cotton RGH. Tryptophan Hydroxylase and Protein Kinase Interactions; Does Phosphorylation Cause Activation? Pteridines. 3: 61-62. DOI: 10.1515/Pteridines.1991.3.12.61  0.477
1989 Salah RS, Kuhn DM, Galloway MP. Dopamine autoreceptors modulate the phosphorylation of tyrosine hydroxylase in rat striatal slices. Journal of Neurochemistry. 52: 1517-22. PMID 2565375 DOI: 10.1111/J.1471-4159.1989.Tb09202.X  0.33
1979 White FJ, Appel JB, Kuhn DM. Discriminative stimulus properties of quipazine: direct serotonergic mediation. Neuropharmacology. 18: 143-51. PMID 34803 DOI: 10.1016/0028-3908(79)90054-6  0.559
1978 Kuhn DM, White FJ, Appel JB. The discriminative stimulus properties of LSD: mechanisms of action. Neuropharmacology. 17: 257-63. PMID 652138 DOI: 10.1016/0028-3908(78)90109-0  0.546
1977 White F, Kuhn D, Appel J. Discriminative stimulus properties of quipazine Neuropharmacology. 16: 827-832. DOI: 10.1016/0028-3908(77)90144-7  0.541
1976 Kuhn DM, Greenberg I, Appel JB. Stimulus properties of the narcotic antagonist pentazocine: similarity to morphine and antagonism by naloxone. The Journal of Pharmacology and Experimental Therapeutics. 196: 121-7. PMID 1246006  0.367
1976 Kuhn DM, White FJ, Appel JB. Discriminable stimuli produced by hallucinogens. Psychopharmacology Communications. 2: 345-8. PMID 996285  0.551
1975 Greenberg I, Kuhn DM, Appel JB. Behaviorally induced sensitivity to the discriminable properties of LSD. Psychopharmacologia. 43: 229-32. PMID 1187955 DOI: 10.1007/BF00429255  0.407
1974 Kuhn DM, Appel JB, Greenberg I. An analysis of some discriminative properties of d-amphetamine. Psychopharmacologia. 39: 57-66. PMID 4138622 DOI: 10.1007/BF00421458  0.352
1974 Kuhn DM, Greenberg I, Appel JB. Differential effects on lever choice and response rate produced by d-amphetamine Bulletin of the Psychonomic Society. 3: 119-120. DOI: 10.3758/BF03333413  0.371
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