Rick T. Dobrowsky - Publications

Affiliations: 
Neurosciences University of Kansas, Lawrence, KS, United States 
Area:
Neuroscience Biology, Biochemistry, Pharmacology

50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Ghosh S, Shinogle HE, Galeva NA, Dobrowsky RT, Blagg BS. Endoplasmic Reticulum Resident Heat Shock Protein 90 (Hsp90) Isoform Glucose-Regulated Protein 94 (Grp94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport. The Journal of Biological Chemistry. PMID 26872972 DOI: 10.1074/jbc.M115.688374  0.52
2016 Anyika M, McMullen M, Forsberg LK, Dobrowsky RT, Blagg BS. Development of Noviomimetics as C-Terminal Hsp90 Inhibitors. Acs Medicinal Chemistry Letters. 7: 67-71. PMID 26819668 DOI: 10.1021/acsmedchemlett.5b00331  0.52
2016 Emery SM, Dobrowsky RT. Promoting Neuronal Tolerance of Diabetic Stress: Modulating Molecular Chaperones International Review of Neurobiology. DOI: 10.1016/bs.irn.2016.03.001  0.52
2015 Qian P, He XC, Paulson A, Li Z, Tao F, Perry JM, Guo F, Zhao M, Zhi L, Venkatraman A, Haug JS, Parmely T, Li H, Dobrowsky RT, Ding WX, et al. The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism. Cell Stem Cell. PMID 26627594 DOI: 10.1016/j.stem.2015.11.001  0.52
2015 Ma J, Pan P, Anyika M, Blagg BS, Dobrowsky RT. Modulating Molecular Chaperones Improves Mitochondrial Bioenergetics and Decreases the Inflammatory Transcriptome in Diabetic Sensory Neurons. Acs Chemical Neuroscience. PMID 26161583 DOI: 10.1021/acschemneuro.5b00165  0.52
2015 Ghosh S, Shinogle HE, Garg G, Vielhauer GA, Holzbeierlein JM, Dobrowsky RT, Blagg BS. Hsp90 C-terminal inhibitors exhibit antimigratory activity by disrupting the Hsp90α/Aha1 complex in PC3-MM2 cells. Acs Chemical Biology. 10: 577-90. PMID 25402753 DOI: 10.1021/cb5008713  0.52
2014 Ma J, Farmer KL, Pan P, Urban MJ, Zhao H, Blagg BS, Dobrowsky RT. Heat shock protein 70 is necessary to improve mitochondrial bioenergetics and reverse diabetic sensory neuropathy following KU-32 therapy. The Journal of Pharmacology and Experimental Therapeutics. 348: 281-92. PMID 24263156 DOI: 10.1124/jpet.113.210435  0.52
2013 Pan P, Dobrowsky RT. Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy. Acta Neuropathologica Communications. 1: 39. PMID 24252174 DOI: 10.1186/2051-5960-1-39  0.52
2012 Li C, Ma J, Zhao H, Blagg BS, Dobrowsky RT. Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun. Asn Neuro. 4: e00102. PMID 23240583 DOI: 10.1042/20120047  0.52
2012 Farmer KL, Li C, Dobrowsky RT. Diabetic peripheral neuropathy: should a chaperone accompany our therapeutic approach? Pharmacological Reviews. 64: 880-900. PMID 22885705 DOI: 10.1124/pr.111.005314  0.52
2012 Kusuma BR, Zhang L, Sundstrom T, Peterson LB, Dobrowsky RT, Blagg BS. Synthesis and evaluation of novologues as C-terminal Hsp90 inhibitors with cytoprotective activity against sensory neuron glucotoxicity. Journal of Medicinal Chemistry. 55: 5797-812. PMID 22702513 DOI: 10.1021/jm300544c  0.52
2012 Urban MJ, Pan P, Farmer KL, Zhao H, Blagg BS, Dobrowsky RT. Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy. Experimental Neurology. 235: 388-96. PMID 22465570 DOI: 10.1016/j.expneurol.2012.03.005  0.52
2012 Zhang L, Zhao H, Blagg BS, Dobrowsky RT. C-terminal heat shock protein 90 inhibitor decreases hyperglycemia-induced oxidative stress and improves mitochondrial bioenergetics in sensory neurons. Journal of Proteome Research. 11: 2581-93. PMID 22413817 DOI: 10.1021/pr300056m  0.52
2012 Urban MJ, Dobrowsky RT, Blagg BS. Heat shock response and insulin-associated neurodegeneration. Trends in Pharmacological Sciences. 33: 129-37. PMID 22172248 DOI: 10.1016/j.tips.2011.11.001  0.52
2011 Chowdhury SK, Dobrowsky RT, Fernyhough P. Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes. Mitochondrion. 11: 845-54. PMID 21742060 DOI: 10.1016/j.mito.2011.06.007  0.52
2011 Akude E, Zherebitskaya E, Chowdhury SK, Smith DR, Dobrowsky RT, Fernyhough P. Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats. Diabetes. 60: 288-97. PMID 20876714 DOI: 10.2337/db10-0818  0.52
2010 Haenchen SD, Utter JA, Bayless AM, Dobrowsky RT, Davido DJ. Role of a cdk5-associated protein, p35, in herpes simplex virus type 1 replication in vivo. Journal of Neurovirology. 16: 405-9. PMID 20839922 DOI: 10.3109/13550284.2010.513030  0.52
2010 Urban MJ, Li C, Yu C, Lu Y, Krise JM, McIntosh MP, Rajewski RA, Blagg BS, Dobrowsky RT. Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in diabetic mice. Asn Neuro. 2: e00040. PMID 20711301 DOI: 10.1042/AN20100015  0.52
2010 Sharov VS, Dremina ES, Galeva NA, Gerstenecker GS, Li X, Dobrowsky RT, Stobaugh JF, Schöneich C. Fluorogenic Tagging of Peptide and Protein 3-Nitrotyrosine with 4-(Aminomethyl)-benzenesulfonic Acid for Quantitative Analysis of Protein Tyrosine Nitration. Chromatographia. 71: 37-53. PMID 20703364 DOI: 10.1365/s10337-009-1409-0  0.52
2010 Oien DB, Ortiz AN, Rittel AG, Dobrowsky RT, Johnson MA, Levant B, Fowler SC, Moskovitz J. Dopamine D(2) receptor function is compromised in the brain of the methionine sulfoxide reductase A knockout mouse. Journal of Neurochemistry. 114: 51-61. PMID 20374422 DOI: 10.1111/j.1471-4159.2010.06721.x  0.52
2010 Zhang L, Yu C, Vasquez FE, Galeva N, Onyango I, Swerdlow RH, Dobrowsky RT. Hyperglycemia alters the schwann cell mitochondrial proteome and decreases coupled respiration in the absence of superoxide production. Journal of Proteome Research. 9: 458-71. PMID 19905032 DOI: 10.1021/pr900818g  0.52
2009 McGuire JF, Rouen S, Siegfreid E, Wright DE, Dobrowsky RT. Caveolin-1 and altered neuregulin signaling contribute to the pathophysiological progression of diabetic peripheral neuropathy. Diabetes. 58: 2677-86. PMID 19675140 DOI: 10.2337/db09-0594  0.52
2008 Yu C, Rouen S, Dobrowsky RT. Hyperglycemia and downregulation of caveolin-1 enhance neuregulin-induced demyelination. Glia. 56: 877-87. PMID 18338795 DOI: 10.1002/glia.20662  0.52
2007 Seyb KI, Ansar S, Li G, Bean J, Michaelis ML, Dobrowsky RT. p35/Cyclin-dependent kinase 5 is required for protection against beta-amyloid-induced cell death but not tau phosphorylation by ceramide. Journal of Molecular Neuroscience : Mn. 31: 23-35. PMID 17416967 DOI: 10.1007/BF02686115  0.52
2007 Christianson JA, Ryals JM, Johnson MS, Dobrowsky RT, Wright DE. Neurotrophic modulation of myelinated cutaneous innervation and mechanical sensory loss in diabetic mice. Neuroscience. 145: 303-13. PMID 17223273 DOI: 10.1016/j.neuroscience.2006.11.064  0.52
2005 Yu C, Alterman M, Dobrowsky RT. Ceramide displaces cholesterol from lipid rafts and decreases the association of the cholesterol binding protein caveolin-1. Journal of Lipid Research. 46: 1678-91. PMID 15863835 DOI: 10.1194/jlr.M500060-JLR200  0.52
2005 Ilsley JN, Nakanishi M, Flynn C, Belinsky GS, De Guise S, Adib JN, Dobrowsky RT, Bonventre JV, Rosenberg DW. Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis. Cancer Research. 65: 2636-43. PMID 15805260 DOI: 10.1158/0008-5472.CAN-04-3446  0.52
2005 Dobrowsky RT, Rouen S, Yu C. Altered neurotrophism in diabetic neuropathy: spelunking the caves of peripheral nerve. The Journal of Pharmacology and Experimental Therapeutics. 313: 485-91. PMID 15608075 DOI: 10.1124/jpet.104.079921  0.52
2003 Tan W, Rouen S, Barkus KM, Dremina YS, Hui D, Christianson JA, Wright DE, Yoon SO, Dobrowsky RT. Nerve growth factor blocks the glucose-induced down-regulation of caveolin-1 expression in Schwann cells via p75 neurotrophin receptor signaling. The Journal of Biological Chemistry. 278: 23151-62. PMID 12679365 DOI: 10.1074/jbc.M212986200  0.52
2003 Li G, Faibushevich A, Turunen BJ, Yoon SO, Georg G, Michaelis ML, Dobrowsky RT. Stabilization of the cyclin-dependent kinase 5 activator, p35, by paclitaxel decreases beta-amyloid toxicity in cortical neurons. Journal of Neurochemistry. 84: 347-62. PMID 12558997 DOI: 10.1046/j.1471-4159.2003.01526.x  0.52
2003 Chavez JA, Knotts TA, Wang LP, Li G, Dobrowsky RT, Florant GL, Summers SA. A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. The Journal of Biological Chemistry. 278: 10297-303. PMID 12525490 DOI: 10.1074/jbc.M212307200  0.52
2002 Michaelis ML, Dobrowsky RT, Li G. Tau neurofibrillary pathology and microtubule stability. Journal of Molecular Neuroscience : Mn. 19: 289-93. PMID 12540054 DOI: 10.1385/JMN:19:3:289  0.52
2002 Sprott KM, Chumley MJ, Hanson JM, Dobrowsky RT. Decreased activity and enhanced nuclear export of CCAAT-enhancer-binding protein beta during inhibition of adipogenesis by ceramide. The Biochemical Journal. 365: 181-91. PMID 12071851 DOI: 10.1042/BJ20020215  0.52
2001 Grigsby RJ, Dobrowsky RT. Inhibition of ceramide production reverses TNF-induced insulin resistance Biochemical and Biophysical Research Communications. 287: 1121-1124. PMID 11587538 DOI: 10.1006/bbrc.2001.5694  0.52
2001 Dobrowsky RT, Kolesnick RN. Analysis of sphingomyelin and ceramide levels and the enzymes regulating their metabolism in response to cell stress Methods in Cell Biology. 66: 135-165. PMID 11396001  0.52
2001 Bilderback TR, Gazula VR, Dobrowsky RT. Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75NTR-dependent sphingolipid signaling pathways Journal of Neurochemistry. 76: 1540-1551. PMID 11238738 DOI: 10.1046/j.1471-4159.2001.00171.x  0.52
2000 Dobrowsky RT, Carter BD. p75 Neurotrophin receptor signaling: Mechanisms for neurotrophic modulation of cell stress? Journal of Neuroscience Research. 61: 237-243. PMID 10900070 DOI: 10.1002/1097-4547(20000801)61:3<237::AID-JNR1>3.0.CO;2-M  0.52
2000 Dobrowsky RT. Sphingolipid signalling domains. Floating on rafts or buried in caves? Cellular Signalling. 12: 81-90. PMID 10679576 DOI: 10.1016/S0898-6568(99)00072-8  0.52
1999 Dobrowsky RT, Gazula VR. Analysis of sphingomyelin hydrolysis in caveolar membranes Methods in Enzymology. 311: 184-193. PMID 10563324 DOI: 10.1016/S0076-6879(00)11080-8  0.52
1999 Bilderback TR, Gazula VR, Lisanti MP, Dobrowsky RT. Caveolin interacts with Trk A and p75(NTR) and regulates neurotrophin signaling pathways Journal of Biological Chemistry. 274: 257-263. PMID 9867838 DOI: 10.1074/jbc.274.1.257  0.52
1998 Dobrowsky RT, Carter BD. Coupling of the p75 neurotrophin receptor to sphingolipid signaling Annals of the New York Academy of Sciences. 845: 32-45. PMID 9668341 DOI: 10.1111/j.1749-6632.1998.tb09660.x  0.52
1997 Bilderback TR, Grigsby RJ, Dobrowsky RT. Association of p75(NTR) with caveolin and localization of neurotrophin- induced sphingomyelin hydrolysis to caveolae Journal of Biological Chemistry. 272: 10922-10927. PMID 9099750 DOI: 10.1074/jbc.272.16.10922  0.52
1996 Casaccia-Bonnefil P, Carter BD, Dobrowsky RT, Chao MV. Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature. 383: 716-9. PMID 8878481 DOI: 10.1038/383716a0  0.52
1995 Dobrowsky RT, Jenkins GM, Hannun YA. Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors. The Journal of Biological Chemistry. 270: 22135-42. PMID 7673191  0.52
1994 Dobrowsky RT, Werner MH, Castellino AM, Chao MV, Hannun YA. Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science (New York, N.Y.). 265: 1596-9. PMID 8079174  0.52
1994 Wolff RA, Dobrowsky RT, Bielawska A, Obeid LM, Hannun YA. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction Journal of Biological Chemistry. 269: 19605-19609. PMID 8034729  0.52
1993 Dobrowsky RT, Hannun YA. Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A Advances in Lipid Research. 25: 91-104. PMID 8396314  0.52
1993 Dobrowsky RT, Kamibayashi C, Mumby MC, Hannun YA. Ceramide activates heterotrimeric protein phosphatase 2A. The Journal of Biological Chemistry. 268: 15523-30. PMID 8393446  0.52
1993 Fishbein JD, Dobrowsky RT, Bielawska A, Garrett S, Hannun YA. Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae Journal of Biological Chemistry. 268: 9255-9261. PMID 8387486  0.52
1992 Dobrowsky RT, Hannun YA. Ceramide stimulates a cytosolic protein phosphatase Journal of Biological Chemistry. 267: 5048-5051. PMID 1312082  0.52
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