Michael S. Kilberg - Publications

Affiliations: 
University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Biochemistry

152 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Tsai CY, Kilberg MS, Husain SZ. The role of asparagine synthetase on nutrient metabolism in pancreatic disease. Pancreatology : Official Journal of the International Association of Pancreatology (Iap) ... [Et Al.]. PMID 32800652 DOI: 10.1016/J.Pan.2020.08.002  0.421
2020 Farabaugh KT, Krokowski D, Guan BJ, Gao Z, Gao XH, Wu J, Jobava R, Ray G, de Jesus TJ, Bianchi MG, Chukwurah E, Bussolati O, Kilberg M, Buchner DA, Sen GC, et al. PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation. Elife. 9. PMID 32175843 DOI: 10.7554/Elife.52241  0.39
2019 Chiu M, Taurino G, Bianchi MG, Kilberg MS, Bussolati O. Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia. Frontiers in Oncology. 9: 1480. PMID 31998641 DOI: 10.3389/Fonc.2019.01480  0.393
2019 Mukherjee A, Ahmed N, Rose F, Ahmad AN, Javed TA, Wen L, Bottino R, Xiao X, Kilberg MS, Husain SZ. Asparagine synthetase is highly expressed at baseline in the pancreas through heightened PERK signaling. Cellular and Molecular Gastroenterology and Hepatology. PMID 31421261 DOI: 10.1016/J.Jcmgh.2019.08.003  0.357
2018 Shan J, Dudenhausen E, Kilberg MS. Induction of early growth response gene 1 (EGR1) by endoplasmic reticulum stress is mediated by the extracellular regulated kinase (ERK) arm of the MAPK pathways. Biochimica Et Biophysica Acta. Molecular Cell Research. PMID 30290239 DOI: 10.1016/J.Bbamcr.2018.09.009  0.408
2018 Hayner JN, Shan J, Kilberg MS. Regulation of the ATF3 gene by a single promoter in response to amino acid availability and endoplasmic reticulum stress in human primary hepatocytes and hepatoma cells. Biochimica Et Biophysica Acta. 1861: 72-79. PMID 29413899 DOI: 10.1016/J.Bbagrm.2018.01.002  0.536
2017 Sacharow SJ, Dudenhausen EE, Lomelino CL, Rodan L, El Achkar CM, Olson HE, Genetti CA, Agrawal PB, McKenna R, Kilberg MS. Characterization of a novel variant in siblings with Asparagine Synthetase Deficiency. Molecular Genetics and Metabolism. PMID 29279279 DOI: 10.1016/J.Ymgme.2017.12.433  0.314
2017 Lomelino CL, Andring JT, McKenna R, Kilberg MS. Asparagine synthetase: Function, structure, and role in disease. The Journal of Biological Chemistry. PMID 29084849 DOI: 10.1074/Jbc.R117.819060  0.414
2017 Wortel IMN, van der Meer LT, Kilberg MS, van Leeuwen FN. Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells. Trends in Endocrinology and Metabolism: Tem. PMID 28797581 DOI: 10.1016/J.Tem.2017.07.003  0.403
2016 Shan J, Zhang F, Sharkey J, Tang TA, Kilberg MS. The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation. Nucleic Acids Research. PMID 27471030 DOI: 10.1093/Nar/Gkw667  0.472
2016 Kilberg MS, Terada N, Shan J. Influence of Amino Acid Metabolism on Embryonic Stem Cell Function and Differentiation. Advances in Nutrition (Bethesda, Md.). 7: 780S-9S. PMID 27422515 DOI: 10.3945/An.115.011031  0.342
2015 Yuniati L, van der Meer LT, Tijchon E, van Ingen Schenau D, van Emst L, Levers M, Palit SA, Rodenbach C, Poelmans G, Hoogerbrugge PM, Shan J, Kilberg MS, Scheijen B, van Leeuwen FN. Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress. Oncotarget. PMID 26657730 DOI: 10.18632/Oncotarget.6519  0.362
2015 Palmer EE, Hayner J, Sachdev R, Cardamone M, Kandula T, Morris P, Dias KR, Tao J, Miller D, Zhu Y, Macintosh R, Dinger ME, Cowley MJ, Buckley MF, Roscioli T, ... ... Kilberg MS, et al. Asparagine Synthetase Deficiency causes reduced proliferation of cells under conditions of limited asparagine. Molecular Genetics and Metabolism. PMID 26318253 DOI: 10.1016/J.Ymgme.2015.08.007  0.388
2015 Guimarães-Camboa N, Stowe J, Aneas I, Sakabe N, Cattaneo P, Henderson L, Kilberg MS, Johnson RS, Chen J, McCulloch AD, Nobrega MA, Evans SM, Zambon AC. HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes. Developmental Cell. 33: 507-21. PMID 26028220 DOI: 10.1016/J.Devcel.2015.04.021  0.341
2015 Crawford RR, Prescott ET, Sylvester CF, Higdon AN, Shan J, Kilberg MS, Mungrue IN. Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element. The Journal of Biological Chemistry. 290: 15878-91. PMID 25931127 DOI: 10.1074/Jbc.M114.635144  0.434
2015 Shan J, Donelan W, Hayner JN, Zhang F, Dudenhausen EE, Kilberg MS. MAPK signaling triggers transcriptional induction of cFOS during amino acid limitation of HepG2 cells. Biochimica Et Biophysica Acta. 1853: 539-48. PMID 25523140 DOI: 10.1016/J.Bbamcr.2014.12.013  0.504
2014 Shan J, Balasubramanian MN, Donelan W, Fu L, Hayner J, Lopez MC, Baker HV, Kilberg MS. A mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-dependent transcriptional program controls activation of the early growth response 1 (EGR1) gene during amino acid limitation. The Journal of Biological Chemistry. 289: 24665-79. PMID 25028509 DOI: 10.1074/Jbc.M114.565028  0.499
2014 Fan AX, Papadopoulos GL, Hossain MA, Lin IJ, Hu J, Tang TM, Kilberg MS, Renne R, Strouboulis J, Bungert J. Genomic and proteomic analysis of transcription factor TFII-I reveals insight into the response to cellular stress. Nucleic Acids Research. 42: 7625-41. PMID 24875474 DOI: 10.1093/Nar/Gku467  0.449
2013 Teske BF, Fusakio ME, Zhou D, Shan J, McClintick JN, Kilberg MS, Wek RC. CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis. Molecular Biology of the Cell. 24: 2477-90. PMID 23761072 DOI: 10.1091/Mbc.E13-01-0067  0.473
2013 Shan J, Hamazaki T, Tang TA, Terada N, Kilberg MS. Activation of the amino acid response modulates lineage specification during differentiation of murine embryonic stem cells. American Journal of Physiology. Endocrinology and Metabolism. 305: E325-35. PMID 23736538 DOI: 10.1152/Ajpendo.00136.2013  0.516
2013 Han J, Back SH, Hur J, Lin YH, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S, Hatzoglou M, Kilberg MS, Sartor MA, Kaufman RJ. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nature Cell Biology. 15: 481-90. PMID 23624402 DOI: 10.1038/Ncb2738  0.399
2013 Balasubramanian MN, Butterworth EA, Kilberg MS. Asparagine synthetase: regulation by cell stress and involvement in tumor biology. American Journal of Physiology. Endocrinology and Metabolism. 304: E789-99. PMID 23403946 DOI: 10.1152/Ajpendo.00015.2013  0.545
2013 Fu L, Kilberg MS. Elevated cJUN expression and an ATF/CRE site within the ATF3 promoter contribute to activation of ATF3 transcription by the amino acid response. Physiological Genomics. 45: 127-37. PMID 23269699 DOI: 10.1152/Physiolgenomics.00160.2012  0.505
2013 Balasubramanian MN, Shan J, Kilberg MS. Dynamic changes in genomic histone association and modification during activation of the ASNS and ATF3 genes by amino acid limitation. The Biochemical Journal. 449: 219-29. PMID 22978410 DOI: 10.1042/Bj20120958  0.511
2012 Shan J, Fu L, Balasubramanian MN, Anthony T, Kilberg MS. ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in Atf4-deficient cells by inhibition of deacetylation. The Journal of Biological Chemistry. 287: 36393-403. PMID 22955275 DOI: 10.1074/Jbc.M112.399600  0.507
2012 Kilberg MS, Balasubramanian M, Fu L, Shan J. The transcription factor network associated with the amino acid response in mammalian cells. Advances in Nutrition (Bethesda, Md.). 3: 295-306. PMID 22585903 DOI: 10.3945/An.112.001891  0.512
2011 Fu L, Balasubramanian M, Shan J, Dudenhausen EE, Kilberg MS. Auto-activation of c-JUN gene by amino acid deprivation of hepatocellular carcinoma cells reveals a novel c-JUN-mediated signaling pathway. The Journal of Biological Chemistry. 286: 36724-38. PMID 21862593 DOI: 10.1074/Jbc.M111.277673  0.467
2011 Bouman L, Schlierf A, Lutz AK, Shan J, Deinlein A, Kast J, Galehdar Z, Palmisano V, Patenge N, Berg D, Gasser T, Augustin R, Trümbach D, Irrcher I, Park DS, ... ... Kilberg MS, et al. Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death and Differentiation. 18: 769-82. PMID 21113145 DOI: 10.1038/Cdd.2010.142  0.342
2010 Shan J, Lopez MC, Baker HV, Kilberg MS. Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells. Physiological Genomics. 41: 315-27. PMID 20215415 DOI: 10.1152/Physiolgenomics.00217.2009  0.555
2009 Kilberg MS, Shan J, Su N. ATF4-dependent transcription mediates signaling of amino acid limitation. Trends in Endocrinology and Metabolism: Tem. 20: 436-43. PMID 19800252 DOI: 10.1016/J.Tem.2009.05.008  0.572
2009 Shan J, Ord D, Ord T, Kilberg MS. Elevated ATF4 expression, in the absence of other signals, is sufficient for transcriptional induction via CCAAT enhancer-binding protein-activating transcription factor response elements. The Journal of Biological Chemistry. 284: 21241-8. PMID 19509279 DOI: 10.1074/Jbc.M109.011338  0.578
2009 Su N, Thiaville MM, Awad K, Gjymishka A, Brant JO, Yang TP, Kilberg MS. Protein or amino acid deprivation differentially regulates the hepatic forkhead box protein A (FOXA) genes through an activating transcription factor-4-independent pathway. Hepatology (Baltimore, Md.). 50: 282-90. PMID 19415718 DOI: 10.1002/Hep.22971  0.833
2009 Palii SS, Kays CE, Deval C, Bruhat A, Fafournoux P, Kilberg MS. Specificity of amino acid regulated gene expression: Analysis of genes subjected to either complete or single amino acid deprivation Amino Acids. 37: 79-88. PMID 19009228 DOI: 10.1007/S00726-008-0199-2  0.572
2009 Gjymishka A, Su N, Kilberg MS. Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathway. The Biochemical Journal. 417: 695-703. PMID 18840095 DOI: 10.1042/Bj20081706  0.502
2008 Su N, Kilberg MS. C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. The Journal of Biological Chemistry. 283: 35106-17. PMID 18940792 DOI: 10.1074/Jbc.M806874200  0.546
2008 Thiaville MM, Dudenhausen EE, Awad KS, Gjymishka A, Zhong C, Kilberg MS. Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex. Nucleic Acids Research. 36: 5571-80. PMID 18757893 DOI: 10.1093/Nar/Gkn538  0.835
2008 Gjymishka A, Palii SS, Shan J, Kilberg MS. Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed in HepG2 cells. The Journal of Biological Chemistry. 283: 27736-47. PMID 18697751 DOI: 10.1074/Jbc.M803781200  0.55
2008 Abbatiello SE, Pan YX, Zhou M, Wayne AS, Veenstra TD, Hunger SP, Kilberg MS, Eyler JR, Richards NG, Conrads TP. Mass spectrometric quantification of asparagine synthetase in circulating leukemia cells from acute lymphoblastic leukemia patients. Journal of Proteomics. 71: 61-70. PMID 18541474 DOI: 10.1016/J.Jprot.2007.11.009  0.313
2008 Thiaville MM, Pan YX, Gjymishka A, Zhong C, Kaufman RJ, Kilberg MS. MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells. The Journal of Biological Chemistry. 283: 10848-57. PMID 18287093 DOI: 10.1074/Jbc.M708320200  0.812
2008 Aiken KJ, Bickford JS, Kilberg MS, Nick HS. Metabolic regulation of manganese superoxide dismutase expression via essential amino acid deprivation. The Journal of Biological Chemistry. 283: 10252-63. PMID 18187411 DOI: 10.1074/Jbc.M709944200  0.489
2008 Thiaville MM, Dudenhausen EE, Zhong C, Pan YX, Kilberg MS. Deprivation of protein or amino acid induces C/EBPbeta synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription. The Biochemical Journal. 410: 473-84. PMID 18052938 DOI: 10.1042/Bj20071252  0.824
2008 Su N, Pan YX, Zhou M, Harvey RC, Hunger SP, Kilberg MS. Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines. Pediatric Blood & Cancer. 50: 274-9. PMID 17514734 DOI: 10.1002/Pbc.21213  0.31
2007 Pan YX, Chen H, Thiaville MM, Kilberg MS. Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation. The Biochemical Journal. 401: 299-307. PMID 16989641 DOI: 10.1042/Bj20061261  0.836
2006 Gutierrez JA, Pan YX, Koroniak L, Hiratake J, Kilberg MS, Richards NG. An inhibitor of human asparagine synthetase suppresses proliferation of an L-asparaginase-resistant leukemia cell line. Chemistry & Biology. 13: 1339-47. PMID 17185229 DOI: 10.1016/J.Chembiol.2006.10.010  0.3
2006 Chen H, Kilberg MS. Alignment of the transcription start site coincides with increased transcriptional activity from the human asparagine synthetase gene following amino acid deprivation of HepG2 cells. The Journal of Nutrition. 136: 2463-7. PMID 16988110 DOI: 10.1093/Jn/136.10.2463  0.562
2006 Palii SS, Thiaville MM, Pan YX, Zhong C, Kilberg MS. Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene. The Biochemical Journal. 395: 517-27. PMID 16445384 DOI: 10.1042/Bj20051867  0.847
2006 Kilberg MS. Amino acid-dependent signal transduction for control of transport and metabolism Acta Biomedica De L'Ateneo Parmense. 77: 18-20.  0.481
2005 Pan YX, Chen H, Kilberg MS. Interaction of RNA-binding proteins HuR and AUF1 with the human ATF3 mRNA 3'-untranslated region regulates its amino acid limitation-induced stabilization. The Journal of Biological Chemistry. 280: 34609-16. PMID 16109718 DOI: 10.1074/Jbc.M507802200  0.473
2005 Chen C, Dudenhausen E, Chen H, Pan YX, Gjymishka A, Kilberg MS. Amino-acid limitation induces transcription from the human C/EBPbeta gene via an enhancer activity located downstream of the protein coding sequence. The Biochemical Journal. 391: 649-58. PMID 16026328 DOI: 10.1042/Bj20050882  0.599
2005 Kilberg MS, Pan YX, Chen H, Leung-Pineda V. Nutritional control of gene expression: How mammalian cells respond to amino acid limitation Annual Review of Nutrition. 25: 59-85. PMID 16011459 DOI: 10.1146/Annurev.Nutr.24.012003.132145  0.545
2004 Chen H, Pan YX, Dudenhausen EE, Kilberg MS. Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation. The Journal of Biological Chemistry. 279: 50829-39. PMID 15385533 DOI: 10.1074/Jbc.M409173200  0.54
2004 Chen C, Dudenhausen EE, Pan YX, Zhong C, Kilberg MS. Human CCAAT/enhancer-binding protein beta gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence. The Journal of Biological Chemistry. 279: 27948-56. PMID 15102854 DOI: 10.1074/Jbc.M313920200  0.456
2004 Leung-Pineda V, Pan Y, Chen H, Kilberg MS. Induction of p21 and p27 expression by amino acid deprivation of HepG2 human hepatoma cells involves mRNA stabilization. The Biochemical Journal. 379: 79-88. PMID 14715082 DOI: 10.1042/Bj20031383  0.466
2004 Palii SS, Chen H, Kilberg MS. Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element. The Journal of Biological Chemistry. 279: 3463-71. PMID 14623874 DOI: 10.1074/Jbc.M310483200  0.576
2003 Burkhardt BR, Loiler SA, Anderson JA, Kilberg MS, Crawford JM, Flotte TR, Goudy KS, Ellis TM, Atkinson M. Glucose-responsive expression of the human insulin promoter in HepG2 human hepatoma cells. Annals of the New York Academy of Sciences. 1005: 237-41. PMID 14679068 DOI: 10.1196/Annals.1288.035  0.32
2003 Pan Y, Chen H, Siu F, Kilberg MS. Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter. The Journal of Biological Chemistry. 278: 38402-12. PMID 12881527 DOI: 10.1074/Jbc.M304574200  0.572
2003 Weiss MD, Derazi S, Rossignol C, Varoqui H, Erickson JD, Kilberg MS, Anderson KJ. Ontogeny of the neutral amino acid transporter SAT1/ATA1 in rat brain. Brain Research. Developmental Brain Research. 143: 151-9. PMID 12855186 DOI: 10.1016/S0165-3806(03)00107-X  0.324
2003 Zhong C, Chen C, Kilberg MS. Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter. The Biochemical Journal. 372: 603-9. PMID 12628003 DOI: 10.1042/Bj20030076  0.502
2003 Chang SH, Garcia J, Melendez JA, Kilberg MS, Agarwal A. Haem oxygenase 1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron-transport chain. The Biochemical Journal. 371: 877-85. PMID 12585963 DOI: 10.1042/Bj20021731  0.383
2002 Bain PJ, LeBlanc-Chaffin R, Chen H, Palii SS, Leach KM, Kilberg MS. The mechanism for transcriptional activation of the human ATA2 transporter gene by amino acid deprivation is different than that for asparagine synthetase. The Journal of Nutrition. 132: 3023-9. PMID 12368390 DOI: 10.1093/Jn/131.10.3023  0.828
2002 Bruhat A, Averous J, Carraro V, Zhong C, Reimold AM, Kilberg MS, Fafournoux P. Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response. The Journal of Biological Chemistry. 277: 48107-14. PMID 12351626 DOI: 10.1074/Jbc.M206149200  0.585
2002 Yang W, Kilberg MS. Biosynthesis, intracellular targeting, and degradation of the EAAC1 glutamate/aspartate transporter in C6 glioma cells. The Journal of Biological Chemistry. 277: 38350-7. PMID 12151387 DOI: 10.1074/Jbc.M202052200  0.415
2002 Kilberg MS, Barbosa-Tessmann IP. Genomic sequences necessary for transcriptional activation by amino acid deprivation of mammalian cells. The Journal of Nutrition. 132: 1801-4. PMID 12097650 DOI: 10.1093/Jn/132.7.1801  0.787
2002 Siu F, Bain PJ, LeBlanc-Chaffin R, Chen H, Kilberg MS. ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. The Journal of Biological Chemistry. 277: 24120-7. PMID 11960987 DOI: 10.1074/Jbc.M201959200  0.81
2002 Leung-Pineda V, Kilberg MS. Role of Sp1 and Sp3 in the nutrient-regulated expression of the human asparagine synthetase gene. The Journal of Biological Chemistry. 277: 16585-91. PMID 11867623 DOI: 10.1074/Jbc.M110972200  0.463
2002 Cramer S, Beveridge M, Kilberg M, Novak D. Physiological importance of system A-mediated amino acid transport to rat fetal development American Journal of Physiology - Cell Physiology. 282. PMID 11742808 DOI: 10.1152/Ajpcell.2002.282.1.C153  0.457
2002 Chang SH, Barbosa-Tessmann I, Chen C, Kilberg MS, Agarwal A. Glucose deprivation induces heme oxygenase-1 gene expression by a pathway independent of the unfolded protein response. The Journal of Biological Chemistry. 277: 1933-40. PMID 11707454 DOI: 10.1074/Jbc.M108921200  0.752
2001 Siu F, Chen C, Zhong C, Kilberg MS. CCAAT/Enhancer-binding Protein-β Is a Mediator of the Nutrient-sensing Response Pathway That Activates the Human Asparagine Synthetase Gene Journal of Biological Chemistry. 276: 48100-48107. PMID 11677247 DOI: 10.1074/Jbc.M109533200  0.549
2001 Weiss MD, Derazi S, Kilberg MS, Anderson KJ. Ontogeny and localization of the neutral amino acid transporter ASCT1 in rat brain Developmental Brain Research. 130: 183-190. PMID 11675121 DOI: 10.1016/S0165-3806(01)00250-4  0.419
2001 Aslanian AM, Kilberg MS. Multiple adaptive mechanisms affect asparagine synthetase substrate availability in asparaginase-resistant MOLT-4 human leukaemia cells Biochemical Journal. 358: 59-67. PMID 11485552 DOI: 10.1042/0264-6021:3580059  0.792
2001 Aslanian AM, Fletcher BS, Kilberg MS. Asparagine synthetase expression alone is sufficient to induce L-asparaginase resistance in MOLT-4 human leukaemia cells Biochemical Journal. 357: 321-328. PMID 11415466 DOI: 10.1042/0264-6021:3570321  0.761
2000 Barbosa-Tessmann IP, Chen C, Zhong C, Siu F, Schuster SM, Nick HS, Kilberg MS. Activation of the human asparagine synthetase gene by the amino acid response and the endoplasmic reticulum stress response pathways occurs by common genomic elements Journal of Biological Chemistry. 275: 26976-26985. PMID 10856289 DOI: 10.1074/Jbc.M000004200  0.791
1999 Barbosa-Tessmann IP, Chen C, Zhong C, Schuster SM, Nick HS, Kilberg MS. Activation of the unfolded protein response pathway induces human asparagine synthetase gene expression Journal of Biological Chemistry. 274: 31139-31144. PMID 10531303 DOI: 10.1074/Jbc.274.44.31139  0.799
1999 Matthews JC, Beveridge MJ, Dialynas E, Bartke A, Kilberg MS, Novak DA. Placental anionic and cationic amino acid transporter expression in growth hormone overexpressing and null IGF-II or null IGF-I receptor mice. Placenta. 20: 639-50. PMID 10527818 DOI: 10.1053/Plac.1999.0421  0.394
1999 Barbosa-Tessmann IP, Pineda VL, Nick HS, Schuster SM, Kilberg MS. Transcriptional regulation of the human asparagine synthetase gene by carbohydrate availability. The Biochemical Journal. 339: 151-8. PMID 10085239 DOI: 10.1042/Bj3390151  0.775
1999 Weiss MD, Aslanian AM, Kilberg MS. Analysis of the Mechanism of the pH-Dependent Shift in Substrate Affinity of ASCT1 Using Site-Directed Mutagenesis: Implications in the Pathophysiology of Hypoxic Ischemic Encephalopathy (HIE) Pediatric Research. 45: 233A-233A. DOI: 10.1203/00006450-199904020-01385  0.743
1998 Matthews JC, Beveridge MJ, Malandro MS, Kilberg MS, Novak DA. Response of placental amino acid transport to gestational age and intrauterine growth retardation Proceedings of the Nutrition Society. 57: 257-263. PMID 9656329  0.305
1998 Matthews JC, Beveridge MJ, Malandro MS, Rothstein JD, Campbell-Thompson M, Verlander JW, Kilberg MS, Novak DA. Activity and protein localization of multiple glutamate transporters in gestation day 14 vs. day 20 rat placenta. The American Journal of Physiology. 274: C603-14. PMID 9530091 DOI: 10.1152/Ajpcell.1998.274.3.C603  0.336
1997 Matthews JC, Aslanian AM, McDonald KK, Yang W, Malandro MS, Novak DA, Kilberg MS. An expression system for mammalian amino acid transporters using a stably maintained episomal vector Analytical Biochemistry. 254: 208-214. PMID 9417778 DOI: 10.1006/Abio.1997.2432  0.793
1997 McDonald KK, Zharikov S, Block ER, Kilberg MS. A caveolar complex between the cationic amino acid transporter 1 and endothelial nitric-oxide synthase may explain the 'arginine paradox' Journal of Biological Chemistry. 272: 31213-31216. PMID 9395443 DOI: 10.1074/Jbc.272.50.31213  0.322
1997 Novak DA, Matthews JC, Beveridge MJ, Yao SYM, Young J, Kilberg MS. Demonstration of system y+L activity on the basal plasma membrane surface of rat placenta and developmentally regulated expression of 4F2HC mRNA Placenta. 18: 643-648. PMID 9364599 DOI: 10.1016/S0143-4004(97)90005-9  0.383
1997 Hyatt SL, Aulak KS, Malandro M, Kilberg MS, Hatzoglou M. Adaptive regulation of the cationic amino acid transporter-1 (Cat-1) in Fao cells Journal of Biological Chemistry. 272: 19951-19957. PMID 9242663 DOI: 10.1074/Jbc.272.32.19951  0.57
1997 Hutson RG, Kitoh T, Moraga Amador DA, Cosic S, Schuster SM, Kilberg MS. Amino acid control of asparagine synthetase: Relation to asparaginase resistance in human leukemia cells American Journal of Physiology - Cell Physiology. 272. PMID 9176161 DOI: 10.1152/Ajpcell.1997.272.5.C1691  0.564
1997 McDonald KK, Rouhani R, Handlogten ME, Block ER, Griffith OW, Allison RD, Kilberg MS. Inhibition of endothelial cell amino acid transport System y+ by arginine analogs that inhibit nitric oxide synthase Biochimica Et Biophysica Acta - Biomembranes. 1324: 133-141. PMID 9059506 DOI: 10.1016/S0005-2736(96)00226-X  0.369
1996 Malandro MS, Beveridge MJ, Novak DA, Kilberg MS. Rat placental amino acid transport after protein-deprivation-induced intrauterine growth retardation Biochemical Society Transactions. 24: 839-843. PMID 8878858 DOI: 10.1042/Bst0240839  0.448
1996 Malandro MS, Kilberg MS. Molecular biology of mammalian amino acid transporters Annual Review of Biochemistry. 65: 305-336. PMID 8811182 DOI: 10.1146/Annurev.Bi.65.070196.001513  0.47
1996 Handlogten ME, Dudenhausen EE, Yang W, Kilberg MS. Association of hepatic system A amino acid transporter with the membrane-cytoskeletal proteins ankyrin and fodrin Biochimica Et Biophysica Acta - Biomembranes. 1282: 107-114. PMID 8679646 DOI: 10.1016/0005-2736(96)00046-6  0.436
1996 Laine RO, Hutson RG, Kilberg MS. Eukaryotic gene expression: metabolite control by amino acids Progress in Nucleic Acid Research and Molecular Biology. 53: 219-248. PMID 8650304 DOI: 10.1016/S0079-6603(08)60146-4  0.55
1996 Tamarappoo BK, McDonald KK, Kilberg MS. Expressed human hippocampal ASCT1 amino acid transporter exhibits a pH-dependent change in substrate specificity Biochimica Et Biophysica Acta - Biomembranes. 1279: 131-136. PMID 8603078 DOI: 10.1016/0005-2736(95)00259-6  0.482
1996 Malandro MS, Beveridge MJ, Kilberg MS, Novak DA. Effect of low-protein diet-induced intrauterine growth retardation on rat placental amino acid transport American Journal of Physiology. 271. DOI: 10.1152/Ajpcell.1996.271.1.C295  0.473
1996 Hutson RG, Warskulat U, Häussinger D, Kilberg MS. An example of nutrient control of gene expression: Amino acid-dependent regulation of asparagine synthetase Clinical Nutrition. 15: 327-331. DOI: 10.1016/S0261-5614(96)80009-4  0.548
1995 Christensen HN, Kilberg M. Hepatic amino acid transport primary to the urea cycle in regulation of biologic neutrality Nutrition Reviews. 53: 74-76. PMID 7770188 DOI: 10.1111/j.1753-4887.1995.tb01506.x  0.335
1994 Kilberg MS, Hutson RG, Laine RO. Amino acid-regulated gene expression in eukaryotic cells Faseb Journal. 8: 13-19. PMID 8299885 DOI: 10.1096/Fasebj.8.1.8299885  0.574
1994 Laine RO, Shay NF, Kilberg MS. Nuclear retention of the induced mRNA following amino acid-dependent transcriptional regulation of mammalian ribosomal proteins L17 and S25 Journal of Biological Chemistry. 269: 9693-9697. PMID 8144559  0.366
1994 Tamarappoo BK, Singh HP, Kilberg MS. Protein modification of glutamine transporters in SV40-transformed hepatocytes and immunodetection of proteins associated with hepatic System N transport activity Journal of Nutrition. 124. PMID 8064408 DOI: 10.1093/Jn/124.Suppl_8.1493S  0.39
1994 Novak DA, Kilberg MS, Beveridge MJ. Ontogeny and plasma-membrane domain localization of amino acid transport system L in rat liver Biochemical Journal. 301: 671-674. PMID 8053892 DOI: 10.1042/Bj3010671  0.306
1994 Malandro MS, Beveridge MJ, Kilberg MS, Novak DA. Ontogeny of cationic amino acid transport systems in rat placenta American Journal of Physiology - Cell Physiology. 267. PMID 7943209 DOI: 10.1152/Ajpcell.1994.267.3.C804  0.404
1994 Hutson RG, Kilberg MS. Cloning of rat asparagine synthetase and specificity of the amino acid-dependent control of its mRNA content Biochemical Journal. 304: 745-750. PMID 7818476 DOI: 10.1042/Bj3040745  0.51
1994 Woodard MH, Dunn WA, Laine RO, Malandro M, McMahon R, Simell O, Block ER, Kilberg MS. Plasma membrane clustering of system y+ (CAT-1) amino acid transporter as detected by immunohistochemistry Am.J.Physiol.. 266. DOI: 10.1152/Ajpendo.1994.266.5.E817  0.487
1993 Kilberg MS, Stevens BR, Novak DA. Recent advances in mammalian amino acid transport Annual Review of Nutrition. 13: 137-165. PMID 8369142 DOI: 10.1146/Annurev.Nu.13.070193.001033  0.489
1993 Shafqat S, Tamarappoo BK, Kilberg MS, Puranam RS, McNamara JO, Guadaño-Ferraz A, Fremeau RT. Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. The Journal of Biological Chemistry. 268: 15351-5. PMID 8340364 DOI: 10.13039/100000002  0.5
1993 Chiles TC, Laine RO, Shay NF, Handlogten ME, Nick HS, Kilberg MS. Enhanced mRNA content in response to amino acid starvation for a 73 kDa protein of the inner mitochondrial membrane. Biochemical and Biophysical Research Communications. 193: 1068-75. PMID 8323532 DOI: 10.1006/Bbrc.1993.1734  0.498
1993 Tamarappoo BK, Nam M, Kilberg MS, Welbourne TC. Glucocorticoid regulation of splanchnic glutamine, alanine, glutamate, ammonia, and glutathione fluxes American Journal of Physiology - Endocrinology and Metabolism. 264. PMID 8097375 DOI: 10.1152/Ajpendo.1993.264.4.E526  0.376
1992 Cariappa R, Kilberg MS. Plasma membrane domain localization and transcytosis of the glucagon-induced hepatic system A carrier. The American Journal of Physiology. 263: E1021-8. PMID 1335691 DOI: 10.1152/Ajpendo.1992.263.6.E1021  0.392
1991 Bode BP, Kilberg MS. Amino acid-dependent increase in hepatic system N activity is linked to cell swelling Journal of Biological Chemistry. 266: 7376-7381. PMID 2019573  0.418
1991 Tamarappoo BK, Kilberg MS. Functional reconstitution of the hepatic System N amino acid transport activity Biochemical Journal. 274: 97-101. PMID 2001257 DOI: 10.1042/Bj2740097  0.39
1991 Wilde SW, Kilberg MS. Glutamine transport by basolateral plasma-membrane vesicles prepared from rabbit intestine Biochemical Journal. 277: 687-691. PMID 1908221 DOI: 10.1042/Bj2770687  0.363
1990 Bode B, Tamarappoo BK, Mailliard M, Kilberg MS. Characteristics and regulation of hepatic glutamine transport Journal of Parenteral and Enteral Nutrition. 14. PMID 2402055 DOI: 10.1177/014860719001400404  0.431
1990 Mailliard ME, Kilberg MS. Sodium-dependent neutral amino acid transport by human liver plasma membrane vesicles Journal of Biological Chemistry. 265: 14321-14326. PMID 2387853  0.366
1990 Tarnuzzer RW, Campa MJ, Qian NX, Englesberg E, Kilberg MS. Expression of the mammalian system A neutral amino acid transporter in Xenopus oocytes. The Journal of Biological Chemistry. 265: 13914-7. PMID 2380194  0.339
1990 Shay NF, Nick HS, Kilberg MS. Molecular cloning of an amino acid-regulated mRNA (amino acid starvation-induced) in rat hepatoma cells. The Journal of Biological Chemistry. 265: 17844-8. PMID 2211664  0.381
1990 Fong AD, Handlogten ME, Kilberg MS. Substrate-dependent adaptive regulation and trans-inhibition of system A-mediated amino acid transport. Studies using rat hepatoma plasma membrane vesicles Bba - Biomembranes. 1022: 325-332. PMID 1690572 DOI: 10.1016/0005-2736(90)90281-R  0.486
1989 Fafournoux P, Dudenhausen EE, Kilberg MS. Solubilization and reconstitution characteristics of hepatic System A-mediated amino acid transport Journal of Biological Chemistry. 264: 4805-4811. PMID 2925669  0.329
1989 Campa MJ, Kilberg MS. Characterization of neutral and cationic amino acid transport in Xenopus oocytes Journal of Cellular Physiology. 141: 645-652. PMID 2592432 DOI: 10.1002/Jcp.1041410324  0.443
1989 Kilberg MS. Measurement of amino acid transport by hepatocytes in suspension or monolayer culture Methods in Enzymology. 173: 564-575. PMID 2550731 DOI: 10.1016/S0076-6879(89)73039-1  0.35
1988 Kilberg MS, Handlogten ME. Transport of branched-chain amino acids and their corresponding 2-keto acids by mammalian cells Methods in Enzymology. 166: 252-260. PMID 3071709 DOI: 10.1016/S0076-6879(88)66034-4  0.488
1988 Chiles TC, Dudeck-Collart KL, Kilberg MS. Inactivation of amino acid transport in rat hepatocytes and hepatoma cells by PCMBS American Journal of Physiology - Cell Physiology. 255. PMID 2844094 DOI: 10.1152/Ajpcell.1988.255.3.C340  0.486
1988 Handlogten ME, Kilberg MS. Growth-dependent regulation of system A in SV40-transformed fetal rat hepatocytes American Journal of Physiology - Cell Physiology. 255. PMID 2844092 DOI: 10.1152/Ajpcell.1988.255.3.C261  0.345
1987 Bracy DS, Schenerman MA, Kilberg MS. Solubilization and reconstitution of hepatic System A-mediated amino acid transport. Preparation of proteoliposomes containing glucagon-stimulated transport activity Bba - Biomembranes. 899: 51-58. PMID 3567191 DOI: 10.1016/0005-2736(87)90238-0  0.418
1986 Schenerman MA, Kilberg MS. Maintenance of glucagon-stimulated system A amino acid transport activity in rat liver plasma membrane vesicles Bba - Biomembranes. 856: 428-436. PMID 3964688 DOI: 10.1016/0005-2736(86)90133-1  0.408
1986 Bracy DS, Handlogten ME, Barber EF, Han HP, Kilberg MS. Cis-inhibition, trans-inhibition, and repression of hepatic amino acid transport mediated by System A. Substrate specificity and other properties. The Journal of Biological Chemistry. 261: 1514-20. PMID 3944097  0.368
1986 Kilberg MS. Amino acid transport in eukaryotic cells and tissues Federation Proceedings. 45: 2438-2454. PMID 3743784  0.361
1986 Chiles TC, Kilberg MS. System A transport activity in normal rat hepatocytes and transformed liver cells: Substrate protection from inactivation by sulfhydryl-modifying reagents Journal of Cellular Physiology. 129: 321-328. PMID 3023402 DOI: 10.1002/Jcp.1041290309  0.482
1986 Kilberg MS. System A-mediated amino acid transport: metabolic control at the plasma membrane Trends in Biochemical Sciences. 11: 183-186. DOI: 10.1016/0968-0004(86)90138-6  0.45
1985 Handlogten ME, Barber EF, Bracy DS, Kilberg MS. Amino acid-dependent inactivation of glucagon-induced System A transport activity in cultured rat hepatocytes. Molecular and Cellular Endocrinology. 43: 61-9. PMID 4065425 DOI: 10.1016/0303-7207(85)90042-5  0.537
1985 Kilberg MS, Han HP, Barber EF, Chiles TC. Adaptive regulation of neutral amino acid transport System A in rat H4 hepatoma cells. Journal of Cellular Physiology. 122: 290-8. PMID 2578476 DOI: 10.1002/Jcp.1041220219  0.544
1985 Kilberg MS, Barber EF, Handlogten ME. Characteristics and hormonal regulation of amino acid transport system A in isolated rat hepatocytes. Current Topics in Cellular Regulation. 25: 133-63. PMID 2410197 DOI: 10.1016/B978-0-12-152825-6.50009-6  0.501
1985 Gardner DF, Kilberg MS, Wolfe MM. Preferential binding of vasoactive intestinal peptide to hepatic nonparenchymal cells American Journal of Physiology - Gastrointestinal and Liver Physiology. 11. DOI: 10.1152/Ajpgi.1985.248.6.G663  0.301
1984 Bannai S, Christensen HN, Vadgama JV, Ellory JC, Englesberg E, Guidotti GG, Gazzola GC, Kilberg MS, Lajtha A, Sacktor B. Amino acid transport systems. Nature. 311: 308. PMID 6482960  0.344
1984 Weissbach L, Kilberg MS. Amino acid activation of amino acid transport system N early in primary cultures of rat hepatocytes Journal of Cellular Physiology. 121: 133-138. PMID 6480708 DOI: 10.1002/Jcp.1041210116  0.46
1984 Handlogten ME, Kilberg MS. Induction and decay of amino-acid transport in the liver. Turnover of transport activity in isolated hepatocytes after stimulation by diabetes or glucagon Journal of Biological Chemistry. 259: 3519-3525. PMID 6200477  0.311
1984 Chiles TX, Kilberg MS. Adaptive regulation of amino acid transport in rat H4 hepatoma cells Federation Proceedings. 43.  0.376
1983 Barber EF, Handlogten ME, Kilberg MS. Induction of amino acid transport system A in rat hepatocytes is blocked by tunicamycin. The Journal of Biological Chemistry. 258: 11851-5. PMID 6352704  0.425
1983 Kilberg MS, Gwynn MB. Plasma membrane transport of 2-ketoisocaproate by rat hepatocytes in primary culture Journal of Biological Chemistry. 258: 11524-11527. PMID 6352700  0.309
1983 Kilberg MS, Vida TA, Barber EF. Regulation of neutral amino acid transport in hepatocytes isolated from adrenalectomized rats. Journal of Cellular Physiology. 114: 45-52. PMID 6338022 DOI: 10.1002/Jcp.1041140108  0.501
1983 Shotwell MA, Kilberg MS, Oxender DL. The regulation of neutral amino acid transport in mammalian cells Bba - Reviews On Biomembranes. 737: 267-284. PMID 6303424 DOI: 10.1016/0304-4157(83)90003-5  0.519
1982 Handlogten ME, Weissbach L, Kilberg MS. Heterogeneity of Na+-independent 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid and L-leucine transport in isolated rat hepatocytes in primary culture Biochemical and Biophysical Research Communications. 104: 307-313. PMID 7073676 DOI: 10.1016/0006-291X(82)91975-1  0.441
1982 Handlogten ME, Kilberg MS, Christensen HN. Incomplete correspondence between repressive and substrate action by amino acids on transport systems A and N in monolayered rat hepatocytes. Journal of Biological Chemistry. 257: 345-348. PMID 7053375  0.424
1982 Kilberg MS. Amino acid transport in isolated rat hepatocytes The Journal of Membrane Biology. 69: 1-12. PMID 6811749 DOI: 10.1007/Bf01871236  0.515
1982 Handlogten ME, Kilberg MS. Transport System A is not responsive to hormonal stimulation in primary cultures of fetal rat hepatocytes Biochemical and Biophysical Research Communications. 108: 1113-1119. PMID 6758770 DOI: 10.1016/0006-291X(82)92115-5  0.386
1981 Shotwell MA, Jayme DW, Kilberg MS, Oxender DL. Neutral amino acid transport systems in Chinese hamsetr ovary cells Journal of Biological Chemistry. 256: 5422-5427. PMID 7240147  0.411
1981 Kilberg MS, Handlogten ME, Christensen HN. Characteristics of system ASC for transport of neutral amino acids in the isolated rat hepatocyte Journal of Biological Chemistry. 256: 3304-3312. PMID 7204404  0.335
1980 Ohsawa M, Kilberg MS, Kimmel G, Christensen HN. Energization of amino acid transport in energy-depleted Ehrlich cells and plasma membrane vesicles Bba - Biomembranes. 599: 175-190. PMID 7397146 DOI: 10.1016/0005-2736(80)90066-8  0.499
1980 Kilberg MS, Handlogten ME, Christensen HN. Characteristics of an amino acid transport system in rat liver for glutamine, asparagine, histidine, and closely related analogs Journal of Biological Chemistry. 255: 4011-4019. PMID 7372663  0.394
1979 Kilberg MS, Christensen HN, Handlogten ME. Cysteine as a system-specific substrate for transport system ASC in rat hepatocytes Biochemical and Biophysical Research Communications. 88: 744-751. PMID 465067 DOI: 10.1016/0006-291X(79)92110-7  0.474
1978 Kilberg MS, Neuhaus OW. Hormonal control of amino acid transport in the liver of rats exposed to whole-body γ irradiation Radiation Research. 73: 360-372. PMID 204956  0.701
1978 Kilberg MS, Neuhaus OW. Hormonal control of amino acid transport in the liver of rats exposed to whole-body gamma irradiation. Radiation Research. 73: 360-372. DOI: 10.2307/3574827  0.718
1978 Kilberg MS, Neuhaus OW. Hormonal regulation of hepatic amino acid transport Progress in Clinical and Biological Research. 117-130.  0.337
1977 Kilberg MS, Neuhaus OW. Hormonal regulation of hepatic amino acid transport. Journal of Supramolecular Structure. 6: 191-204. PMID 198613 DOI: 10.1002/Jss.400060205  0.709
1977 Kilberg MS, Neuhaus OW. Regulation of amino acid transport by insulin and glucagon in the isolated perfused liver Journal of Supramolecular and Cellular Biochemistry. 6.  0.344
1976 Kilberg MS, Neuhaus OW. The role of stimulated amino acid transport in promoting glycogenesis in the irradiated rat Radiation Research. 66: 597-608. PMID 935346 DOI: 10.2307/3574463  0.728
1975 Kilberg MS, Neuhaus OW. Accumulation of α aminoisobutyric acid by rat tissues after whole body γ irradiation Radiation Research. 64: 546-554. PMID 1197657 DOI: 10.2307/3574244  0.651
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