| Year |
Citation |
Score |
| 2020 |
Henry S, Anand JP, Brinkel AC, McMillan DM, Twarozynski JJ, Loo CE, Traynor JR, Mosberg HI. SAR Matrices Enable Discovery of Mixed Efficacy μ-Opioid Receptor Agonist Peptidomimetics with Simplified Structures through an Aromatic-Amine Pharmacophore. Acs Chemical Neuroscience. PMID 33346631 DOI: 10.1021/acschemneuro.0c00693 |
0.501 |
|
| 2020 |
Henry S, Anand JP, Twarozynski JJ, Brinkel AC, Pogozheva ID, Sears BF, Jutkiewicz EM, Traynor JR, Mosberg HI. Aromatic-Amine Pendants Produce Highly Potent and Efficacious Mixed Efficacy Mu-Opioid Receptor (MOR)/Delta-Opioid Receptor (DOR) Peptidomimetics with Enhanced Metabolic Stability. Journal of Medicinal Chemistry. PMID 31986033 DOI: 10.1021/Acs.Jmedchem.9B01818 |
0.531 |
|
| 2019 |
Koerperich ZM, Ericson MD, Freeman KT, Speth R, Pogozheva ID, Mosberg HI, Haskell-Luevano C. Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AGRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists. Journal of Medicinal Chemistry. PMID 31845801 DOI: 10.1021/Acs.Jmedchem.9B00860 |
0.507 |
|
| 2019 |
Montgomery D, Anand JP, Baber MA, Twarozynski JJ, Hartman JG, Delong LJ, Traynor JR, Mosberg HI. Structure-Activity Relationships of 7-Substituted Dimethyltyrosine-Tetrahydroisoquinoline Opioid Peptidomimetics. Molecules (Basel, Switzerland). 24. PMID 31779072 DOI: 10.3390/Molecules24234302 |
0.549 |
|
| 2019 |
Montgomery D, Anand JP, Griggs N, Fernandez TJ, Hartman JG, Sanchez-Santiago AA, Pogozheva ID, Traynor JR, Mosberg HI. Novel Dimethyltyrosine-Tetrahydroisoquinoline Peptidomimetics with Aromatic Tetrahydroisoquinoline Substitutions Show In Vitro Kappa and Mu Opioid Receptor Agonism. Acs Chemical Neuroscience. PMID 31199621 DOI: 10.1021/Acschemneuro.9B00250 |
0.534 |
|
| 2019 |
Henry S, Fernandez TM, Anand JP, Griggs N, Traynor JR, Mosberg HI. Structural Simplification of a Tetrahydroquinoline Core Peptidomimetic µ-Opioid-Receptor (MOR) Agonist/ δ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability . Journal of Medicinal Chemistry. PMID 30924650 DOI: 10.1021/Acs.Jmedchem.9B00219 |
0.537 |
|
| 2019 |
Nastase AF, Anand JP, Bender AM, Montgomery D, Griggs N, Fernandez TJ, Jutkiewicz EM, Traynor JR, Mosberg HI. Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design. Journal of Medicinal Chemistry. PMID 30916966 DOI: 10.1021/Acs.Jmedchem.9B00378 |
0.55 |
|
| 2018 |
Nastase AF, Griggs NW, Anand JP, Fernandez TJ, Harland AA, Trask TJ, Jutkiewicz EM, Traynor JR, Mosberg HI. Synthesis and pharmacological evaluation of novel C-8 substituted tetrahydroquinolines as balanced-affinity mu/delta opioid ligands for the treatment of pain. Acs Chemical Neuroscience. PMID 29677442 DOI: 10.1021/Acschemneuro.8B00139 |
0.523 |
|
| 2018 |
Anand JP, Kochan KE, Nastase AF, Montgomery D, Griggs NW, Traynor JR, Mosberg HI, Jutkiewicz EM. In Vivo Effects of μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Peptidomimetics Following Acute and Repeated Administration. British Journal of Pharmacology. PMID 29352503 DOI: 10.1111/Bph.14148 |
0.553 |
|
| 2017 |
Harland AA, Pogozheva ID, Griggs NW, Trask TJ, Traynor JR, Mosberg HI. Placement of hydroxy moiety on pendant of peptidomimetic scaffold modulates mu and kappa opioid receptor efficacy. Acs Chemical Neuroscience. PMID 28796483 DOI: 10.1021/Acschemneuro.7B00284 |
0.568 |
|
| 2016 |
Harland AA, Bender AM, Griggs NW, Gao C, Anand JP, Pogozheva ID, Traynor JR, Jutkiewicz EM, Mosberg HI. Effects of N-Substitutions on the Tetrahydroquinoline (THQ) core of Mixed-Efficacy μ-Opioid Receptor (MOR)/ δ-Opioid Receptor (DOR) Ligands. Journal of Medicinal Chemistry. PMID 27148755 DOI: 10.1021/Acs.Jmedchem.6B00308 |
0.583 |
|
| 2016 |
Anand JP, Boyer BT, Mosberg HI, Jutkiewicz EM. The behavioral effects of a mixed efficacy antinociceptive peptide, VRP26, following chronic administration in mice. Psychopharmacology. PMID 27117141 DOI: 10.1007/S00213-016-4296-8 |
0.528 |
|
| 2015 |
Bender AM, Griggs NW, Gao C, Trask TJ, Traynor JR, Mosberg HI. Rapid Synthesis of Boc-2',6'-dimethyl-l-tyrosine and Derivatives and Incorporation into Opioid Peptidomimetics. Acs Medicinal Chemistry Letters. 6: 1199-203. PMID 26713104 DOI: 10.1021/Acsmedchemlett.5B00344 |
0.536 |
|
| 2015 |
Harland AA, Yeomans L, Griggs NW, Anand JP, Pogozheva ID, Jutkiewicz EM, Traynor JR, Mosberg HI. Further Optimization and Evaluation of Bioavailable, Mixed-Efficacy μ-Opioid Receptor (MOR) Agonists/ δ-Opioid Receptor (DOR) Antagonists: Balancing MOR and DOR Affinities. Journal of Medicinal Chemistry. PMID 26524472 DOI: 10.1021/Acs.Jmedchem.5B01270 |
0.564 |
|
| 2015 |
Geng J, Pogozheva ID, Mosberg HI, Raghavan M. Use of Functional Polymorphisms To Elucidate the Peptide Binding Site of TAP Complexes. Journal of Immunology (Baltimore, Md. : 1950). 195: 3436-48. PMID 26324772 DOI: 10.4049/Jimmunol.1500985 |
0.395 |
|
| 2015 |
Bender AM, Griggs NW, Anand JP, Traynor JR, Jutkiewicz EM, Mosberg HI. Asymmetric Synthesis and in Vitro and in Vivo Activity of Tetrahydroquinolines Featuring a Diverse Set of Polar Substitutions at the 6 Position as Mixed-Efficacy μ Opioid Receptor/δ Opioid Receptor Ligands. Acs Chemical Neuroscience. 6: 1428-35. PMID 25938166 DOI: 10.1021/Acschemneuro.5B00100 |
0.55 |
|
| 2014 |
Kumar V, Ridzwan IE, Grivas K, Lewis JW, Clark MJ, Meurice C, Jimenez-Gomez C, Pogozheva I, Mosberg H, Traynor JR, Husbands SM. Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity. Journal of Medicinal Chemistry. 57: 4049-57. PMID 24761755 DOI: 10.1021/Jm401964Y |
0.616 |
|
| 2014 |
Mosberg HI, Yeomans L, Anand JP, Porter V, Sobczyk-Kojiro K, Traynor JR, Jutkiewicz EM. Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance. Journal of Medicinal Chemistry. 57: 3148-53. PMID 24641190 DOI: 10.1021/Jm5002088 |
0.563 |
|
| 2014 |
Anand JP, Porter-Barrus VR, Waldschmidt HV, Yeomans L, Pogozheva ID, Traynor JR, Mosberg HI. Translation of structure-activity relationships from cyclic mixed efficacy opioid peptides to linear analogues. Biopolymers. 102: 107-14. PMID 24436042 DOI: 10.1002/Bip.22437 |
0.596 |
|
| 2014 |
Ding B, Glukhova A, Sobczyk-Kojiro K, Mosberg HI, Tesmer JJ, Chen Z. Unveiling the membrane-binding properties of N-terminal and C-terminal regions of G protein-coupled receptor kinase 5 by combined optical spectroscopies. Langmuir : the Acs Journal of Surfaces and Colloids. 30: 823-31. PMID 24401145 DOI: 10.1021/La404055A |
0.378 |
|
| 2014 |
Bender AM, Clark MJ, Agius MP, Traynor JR, Mosberg HI. Synthesis and evaluation of 4-substituted piperidines and piperazines as balanced affinity μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands. Bioorganic & Medicinal Chemistry Letters. 24: 548-51. PMID 24365161 DOI: 10.1016/J.Bmcl.2013.12.021 |
0.59 |
|
| 2013 |
Mosberg HI, Yeomans L, Harland AA, Bender AM, Sobczyk-Kojiro K, Anand JP, Clark MJ, Jutkiewicz EM, Traynor JR. Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands. Journal of Medicinal Chemistry. 56: 2139-49. PMID 23419026 DOI: 10.1021/Jm400050Y |
0.57 |
|
| 2012 |
Anand JP, Purington LC, Pogozheva ID, Traynor JR, Mosberg HI. Modulation of opioid receptor ligand affinity and efficacy using active and inactive state receptor models. Chemical Biology & Drug Design. 80: 763-70. PMID 22882801 DOI: 10.1111/Cbdd.12014 |
0.622 |
|
| 2012 |
Janovick JA, Pogozheva ID, Mosberg HI, Cornea A, Conn PM. Rescue of misrouted GnRHR mutants reveals its constitutive activity. Molecular Endocrinology (Baltimore, Md.). 26: 1179-88. PMID 22595961 DOI: 10.1210/Me.2012-1089 |
0.321 |
|
| 2012 |
Lomize AL, Mosberg HI, Pogozheva ID. Thermodynamic Approach to Large-Scale Modeling of Alpha-Helices in Membranes Biophysical Journal. 102: 490a-491a. DOI: 10.1016/J.Bpj.2011.11.2688 |
0.374 |
|
| 2011 |
Girnys EA, Porter VR, Mosberg HI. Conformationally restricted analogs of the direct thrombin inhibitor FM 19. Bioorganic & Medicinal Chemistry. 19: 7425-34. PMID 22055408 DOI: 10.1016/J.Bmc.2011.10.045 |
0.39 |
|
| 2011 |
Purington LC, Sobczyk-Kojiro K, Pogozheva ID, Traynor JR, Mosberg HI. Development and in vitro characterization of a novel bifunctional μ-agonist/δ-antagonist opioid tetrapeptide. Acs Chemical Biology. 6: 1375-81. PMID 21958158 DOI: 10.1021/Cb200263Q |
0.573 |
|
| 2011 |
Janovick JA, Pogozheva ID, Mosberg HI, Conn PM. Salt bridges overlapping the gonadotropin-releasing hormone receptor agonist binding site reveal a coincidence detector for G protein-coupled receptor activation. The Journal of Pharmacology and Experimental Therapeutics. 338: 430-42. PMID 21527534 DOI: 10.1124/Jpet.111.180869 |
0.527 |
|
| 2011 |
Lomize AL, Pogozheva ID, Mosberg HI. Anisotropic solvent model of the lipid bilayer. 2. Energetics of insertion of small molecules, peptides, and proteins in membranes. Journal of Chemical Information and Modeling. 51: 930-46. PMID 21438606 DOI: 10.1021/Ci200020K |
0.316 |
|
| 2011 |
Lomize AL, Pogozheva I, Mosberg HI. Large-Scale Computational Analysis of Protein Arrangement in the Lipid Bilayer Biophysical Journal. 100: 492a. DOI: 10.1016/J.Bpj.2010.12.2885 |
0.308 |
|
| 2010 |
René P, Le Gouill C, Pogozheva ID, Lee G, Mosberg HI, Farooqi IS, Valenzano KJ, Bouvier M. Pharmacological chaperones restore function to MC4R mutants responsible for severe early-onset obesity. The Journal of Pharmacology and Experimental Therapeutics. 335: 520-32. PMID 20826565 DOI: 10.1124/Jpet.110.172098 |
0.364 |
|
| 2010 |
Girnys EA, Sobczyk-Kojiro K, Mosberg HI. Structure-based design of residue 1 analogs of the direct thrombin inhibitor pentapeptide FM 19. Chemical Biology & Drug Design. 75: 35-9. PMID 19954432 DOI: 10.1111/J.1747-0285.2009.00915.X |
0.333 |
|
| 2009 |
Purington LC, Pogozheva ID, Traynor JR, Mosberg HI. Pentapeptides displaying mu opioid receptor agonist and delta opioid receptor partial agonist/antagonist properties. Journal of Medicinal Chemistry. 52: 7724-31. PMID 19788201 DOI: 10.1021/Jm9007483 |
0.601 |
|
| 2009 |
Kuszak AJ, Pitchiaya S, Anand JP, Mosberg HI, Walter NG, Sunahara RK. Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. The Journal of Biological Chemistry. 284: 26732-41. PMID 19542234 DOI: 10.1074/Jbc.M109.026922 |
0.561 |
|
| 2009 |
Roof RA, Roman DL, Clements ST, Sobczyk-Kojiro K, Blazer LL, Ota S, Mosberg HI, Neubig RR. A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen. Bmc Pharmacology. 9: 9. PMID 19463173 DOI: 10.1186/1471-2210-9-9 |
0.399 |
|
| 2009 |
Haskell-Luevano C, Xiang Z, Wilczynski AM, Haskell KR, Andreasen AM, Litherland SA, Millard WJ, Pogozheva ID, Mosberg HI, Sorenson NB. Discovery of a ligand that compensates for decreased endogenous agonist potency of melanocortin-4 receptor polymorphisms identified in obese humans. Advances in Experimental Medicine and Biology. 611: 509-10. PMID 19400288 DOI: 10.1007/978-0-387-73657-0_221 |
0.418 |
|
| 2009 |
Tan K, Pogozheva ID, Yeo GS, Hadaschik D, Keogh JM, Haskell-Leuvano C, O'Rahilly S, Mosberg HI, Farooqi IS. Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor. Endocrinology. 150: 114-25. PMID 18801902 DOI: 10.1210/En.2008-0721 |
0.433 |
|
| 2009 |
Lomize AL, Pogozheva ID, Wang S, Mosberg HI. Prediction of Membrane Binding, Orientation and Permeability of Peptide-like Molecules Using a Continuum Model of the Lipid Bilayer Biophysical Journal. 96: 404a-405a. DOI: 10.1016/J.Bpj.2008.12.2060 |
0.318 |
|
| 2008 |
Proneth B, Pogozheva ID, Portillo FP, Mosberg HI, Haskell-Luevano C. Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-3 receptor agonist versus antagonist activity. Journal of Medicinal Chemistry. 51: 5585-93. PMID 18800761 DOI: 10.1021/Jm800291B |
0.533 |
|
| 2008 |
Roof RA, Sobczyk-Kojiro K, Turbiak AJ, Roman DL, Pogozheva ID, Blazer LL, Neubig RR, Mosberg HI. Novel peptide ligands of RGS4 from a focused one-bead, one-compound library. Chemical Biology & Drug Design. 72: 111-9. PMID 18637987 DOI: 10.1111/J.1747-0285.2008.00687.X |
0.422 |
|
| 2008 |
Nieman MT, Burke F, Warnock M, Zhou Y, Sweigart J, Chen A, Ricketts D, Lucchesi BR, Chen Z, Di Cera E, Hilfinger J, Kim JS, Mosberg HI, Schmaier AH. Thrombostatin FM compounds: Direct thrombin inhibitors - Mechanism of action in vitro and in vivo Journal of Thrombosis and Haemostasis. 6: 837-845. PMID 18315550 DOI: 10.1111/J.1538-7836.2008.02937.X |
0.323 |
|
| 2007 |
Lomize AL, Pogozheva ID, Lomize MA, Mosberg HI. The role of hydrophobic interactions in positioning of peripheral proteins in membranes. Bmc Structural Biology. 7: 44. PMID 17603894 DOI: 10.1186/1472-6807-7-44 |
0.349 |
|
| 2007 |
Xiang Z, Pogozheva ID, Sorenson NB, Wilczynski AM, Holder JR, Litherland SA, Millard WJ, Mosberg HI, Haskell-Luevano C. Peptide and small molecules rescue the functional activity and agonist potency of dysfunctional human melanocortin-4 receptor polymorphisms. Biochemistry. 46: 8273-87. PMID 17590021 DOI: 10.1021/Bi7007382 |
0.496 |
|
| 2006 |
Roof RA, Jin Y, Roman DL, Sunahara RK, Ishii M, Mosberg HI, Neubig RR. Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins. Chemical Biology & Drug Design. 67: 266-74. PMID 16629824 DOI: 10.1111/J.1747-0285.2006.00373.X |
0.408 |
|
| 2006 |
Proneth B, Xiang Z, Pogozheva ID, Litherland SA, Gorbatyuk OS, Shaw AM, Millard WJ, Mosberg HI, Haskell-Luevano C. Molecular mechanism of the constitutive activation of the L250Q human melanocortin-4 receptor polymorphism. Chemical Biology & Drug Design. 67: 215-29. PMID 16611215 DOI: 10.1111/J.1747-0285.2006.00362.X |
0.442 |
|
| 2006 |
Jutkiewicz EM, Torregrossa MM, Sobczyk-Kojiro K, Mosberg HI, Folk JE, Rice KC, Watson SJ, Woods JH. Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effects. European Journal of Pharmacology. 531: 151-9. PMID 16442521 DOI: 10.1016/J.Ejphar.2005.12.002 |
0.469 |
|
| 2006 |
Torregrossa MM, Jutkiewicz EM, Mosberg HI, Balboni G, Watson SJ, Woods JH. Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats. Brain Research. 1069: 172-81. PMID 16364263 DOI: 10.1016/J.Brainres.2005.11.005 |
0.447 |
|
| 2005 |
Pogozheva ID, Przydzial MJ, Mosberg HI. Homology modeling of opioid receptor-ligand complexes using experimental constraints. The Aaps Journal. 7: E434-48. PMID 16353922 DOI: 10.1208/Aapsj070243 |
0.796 |
|
| 2005 |
Przydzial MJ, Pogozheva ID, Ho JC, Bosse KE, Sawyer E, Traynor JR, Mosberg HI. Design of high affinity cyclic pentapeptide ligands for kappa-opioid receptors. The Journal of Peptide Research : Official Journal of the American Peptide Society. 66: 255-62. PMID 16218993 DOI: 10.1111/J.1399-3011.2005.00295.X |
0.794 |
|
| 2005 |
Pogozheva ID, Chai BX, Lomize AL, Fong TM, Weinberg DH, Nargund RP, Mulholland MW, Gantz I, Mosberg HI. Interactions of human melanocortin 4 receptor with nonpeptide and peptide agonists. Biochemistry. 44: 11329-41. PMID 16114870 DOI: 10.1021/Bi0501840 |
0.55 |
|
| 2005 |
Przydzial MJ, Pogozheva ID, Bosse KE, Andrews SM, Tharp TA, Traynor JR, Mosberg HI. Roles of residues 3 and 4 in cyclic tetrapeptide ligand recognition by the kappa-opioid receptor. The Journal of Peptide Research : Official Journal of the American Peptide Society. 65: 333-42. PMID 15787963 DOI: 10.1111/J.1399-3011.2005.00220.X |
0.809 |
|
| 2005 |
Chai BX, Pogozheva ID, Lai YM, Li JY, Neubig RR, Mosberg HI, Gantz I. Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors. Biochemistry. 44: 3418-31. PMID 15736952 DOI: 10.1021/Bi0478704 |
0.52 |
|
| 2004 |
Fowler CB, Pogozheva ID, Lomize AL, LeVine H, Mosberg HI. Complex of an active mu-opioid receptor with a cyclic peptide agonist modeled from experimental constraints. Biochemistry. 43: 15796-810. PMID 15595835 DOI: 10.1021/Bi048413Q |
0.637 |
|
| 2004 |
Lomize AL, Pogozheva ID, Mosberg HI. Quantification of helix-helix binding affinities in micelles and lipid bilayers Protein Science. 13: 2600-2612. PMID 15340167 DOI: 10.1110/Ps.04850804 |
0.362 |
|
| 2004 |
Jin Y, Zhong H, Omnaas JR, Neubig RR, Mosberg HI. Structure-based design, synthesis, and activity of peptide inhibitors of RGS4 GAP activity. Methods in Enzymology. 389: 266-77. PMID 15313571 DOI: 10.1016/S0076-6879(04)89016-5 |
0.366 |
|
| 2004 |
Fowler CB, Pogozheva ID, LeVine H, Mosberg HI. Refinement of a homology model of the mu-opioid receptor using distance constraints from intrinsic and engineered zinc-binding sites. Biochemistry. 43: 8700-10. PMID 15236578 DOI: 10.1021/Bi036067R |
0.476 |
|
| 2004 |
Jin Y, Zhong H, Omnaas JR, Neubig RR, Mosberg HI. Structure-based design, synthesis, and pharmacologic evaluation tf peptide RGS4 inhibitors Journal of Peptide Research. 63: 141-146. PMID 15009535 DOI: 10.1111/J.1399-3011.2003.00114.X |
0.366 |
|
| 2003 |
Vig BS, Lorenzi PJ, Mittal S, Landowski CP, Shin HC, Mosberg HI, Hilfinger JM, Amidon GL. Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis. Pharmaceutical Research. 20: 1381-8. PMID 14567631 DOI: 10.1023/A:1025745824632 |
0.303 |
|
| 2003 |
Ko MC, Lee H, Song MS, Sobczyk-Kojiro K, Mosberg HI, Kishioka S, Woods JH, Naughton NN. Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys. The Journal of Pharmacology and Experimental Therapeutics. 305: 173-9. PMID 12649366 DOI: 10.1124/Jpet.102.044909 |
0.448 |
|
| 2002 |
Mosberg HI, Fowler CB. Development and validation of opioid ligand-receptor interaction models: The structural basis of mu vs. delta selectivity Journal of Peptide Research. 60: 329-335. PMID 12464111 DOI: 10.1034/J.1399-3011.2002.21061.X |
0.601 |
|
| 2002 |
Chung DA, Wade SM, Fowler CB, Woods DD, Abada PB, Mosberg HI, Neubig RR. Mutagenesis and peptide analysis of the DRY motif in the alpha2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors. Biochemical and Biophysical Research Communications. 293: 1233-41. PMID 12054508 DOI: 10.1016/S0006-291X(02)00357-1 |
0.457 |
|
| 2002 |
Chung DA, Zuiderweg ER, Fowler CB, Soyer OS, Mosberg HI, Neubig RR. NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix. Biochemistry. 41: 3596-604. PMID 11888275 DOI: 10.1021/Bi015811+ |
0.431 |
|
| 2001 |
Hicks ME, Gomez-Flores R, Wang C, Mosberg HI, Weber RJ. Differential effects of the novel non-peptidic opioid 4-tyrosylamido-6-benzyl-1,2,3,4 tetrahydroquinoline (CGPM-9) on in vitro rat t lymphocyte and macrophage functions Life Sciences. 68: 2685-2694. PMID 11405238 DOI: 10.1016/S0024-3205(01)01083-9 |
0.514 |
|
| 2000 |
McFadyen IJ, Sobczyk-Kojiro K, Schaefer MJ, Ho JC, Omnaas JR, Mosberg HI, Traynor JR. Tetrapeptide derivatives of [D-Pen(2),D-Pen(5)]-enkephalin (DPDPE) lacking an N-terminal tyrosine residue are agonists at the mu-opioid receptor. The Journal of Pharmacology and Experimental Therapeutics. 295: 960-6. PMID 11082429 |
0.526 |
|
| 2000 |
McFadyen IJ, Ho JC, Mosberg HI, Traynor JR. Modifications of the cyclic mu receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]NH2 (Et): effects on opioid receptor binding and activation. The Journal of Peptide Research : Official Journal of the American Peptide Society. 55: 255-61. PMID 10727108 DOI: 10.1034/J.1399-3011.2000.00177.X |
0.638 |
|
| 1999 |
Mosberg HI. Complementarity of δ opioid ligand pharmacophore and receptor models Biopolymers - Peptide Science Section. 51: 426-439. PMID 10797231 DOI: 10.1002/(Sici)1097-0282(1999)51:6<426::Aid-Bip5>3.0.Co;2-G |
0.583 |
|
| 1999 |
Lomize AL, Pogozheva ID, Mosberg HI. Prediction of protein structure: The problem of fold multiplicity Proteins: Structure, Function and Genetics. 37: 199-203. PMID 10526369 DOI: 10.1002/(Sici)1097-0134(1999)37:3+<199::Aid-Prot25>3.0.Co;2-Y |
0.319 |
|
| 1999 |
Johnson MD, Ko M, Choo KS, Traynor JR, Mosberg HI, Naughton NN, Woods JH. The effects of the phyllolitorin analogue [desTrp(3), Leu(8)]phyllolitorin on scratching induced by bombesin and related peptides in rats. Brain Research. 839: 194-8. PMID 10482814 DOI: 10.1016/S0006-8993(99)01708-4 |
0.438 |
|
| 1999 |
Lomize AL, Pogozheva ID, Mosberg HI. Structural organization of G-protein-coupled receptors Journal of Computer-Aided Molecular Design. 13: 325-353. PMID 10425600 DOI: 10.1023/A:1008050821744 |
0.521 |
|
| 1998 |
Wang C, McFadyen IJ, Traynor JR, Mosberg HI. Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models. Bioorganic & Medicinal Chemistry Letters. 8: 2685-8. PMID 9873603 DOI: 10.1016/S0960-894X(98)00472-7 |
0.589 |
|
| 1998 |
Mosberg HI, Ho JC, Sobczyk-Kojiro K. A high affinity, Mu-opioid receptor-selective enkephalin analogue lacking an N-terminal tyrosine Bioorganic and Medicinal Chemistry Letters. 8: 2681-2684. PMID 9873602 DOI: 10.1016/S0960-894X(98)00476-4 |
0.575 |
|
| 1998 |
Pogozheva ID, Lomize AL, Mosberg HI. Opioid receptor three-dimensional structures from distance geometry calculations with hydrogen bonding constraints Biophysical Journal. 75: 612-634. PMID 9675164 DOI: 10.1016/S0006-3495(98)77552-6 |
0.611 |
|
| 1998 |
Butelman ER, Ko MC, Sobczyk-Kojiro K, Mosberg HI, Van Bemmel B, Zernig G, Woods JH. kappa-Opioid receptor binding populations in rhesus monkey brain: relationship to an assay of thermal antinociception. The Journal of Pharmacology and Experimental Therapeutics. 285: 595-601. PMID 9580603 |
0.488 |
|
| 1998 |
Lomize AL, Pogozheva ID, Mosberg HI. Development of a model for the δ‐opioid receptor pharmacophore: 3. Comparison of the cyclic tetrapeptide Tyr‐c[D‐Cys‐Phe‐D‐Pen] OH with other conformationally constrained δ‐receptor selective ligands Biopolymers. 38: 221-234. PMID 8589255 DOI: 10.1002/(Sici)1097-0282(199602)38:2<221::Aid-Bip8>3.0.Co;2-X |
0.603 |
|
| 1997 |
Lomize AL, Mosberg HI. Thermodynamic model of secondary structure for α-helical peptides and proteins Biopolymers. 42: 239-269. PMID 9235002 DOI: 10.1002/(Sici)1097-0282(199708)42:2<239::Aid-Bip12>3.0.Co;2-G |
0.364 |
|
| 1997 |
Pogozheva ID, Lomize AL, Mosberg HI. The transmembrane 7-α-bundle of rhodopsin: Distance geometry calculations with hydrogen bonding constraints Biophysical Journal. 72: 1963-1985. PMID 9129801 DOI: 10.1016/S0006-3495(97)78842-8 |
0.354 |
|
| 1997 |
Mansour A, Taylor LP, Fine JL, Thompson RC, Hoversten MT, Mosberg HI, Watson SJ, Akil H. Key residues defining the mu-opioid receptor binding pocket: a site-directed mutagenesis study. Journal of Neurochemistry. 68: 344-53. PMID 8978745 DOI: 10.1046/J.1471-4159.1997.68010344.X |
0.571 |
|
| 1996 |
Jewett DC, Mosberg HI, Woods JH. Discriminative stimulus effects of a centrally administered, delta-opioid peptide (D-Pen2-D-Pen5-enkephalin) in pigeons. Psychopharmacology. 127: 225-30. PMID 8912400 DOI: 10.1007/Bf02246130 |
0.536 |
|
| 1996 |
Mosberg HI, Dua RK, Pogozheva ID, Lomize AL. Development of a model for the δ-opioid receptor pharmacophore. 4. Residue 3 dehydrophenylalanine analogues of Tyr-c[D-Cys-Phe-D-Pen]OH (JOM- 13) confirm required gauche orientation of aromatic side chain Biopolymers. 39: 287-296. PMID 8756510 DOI: 10.1002/(Sici)1097-0282(199609)39:3<287::Aid-Bip2>3.0.Co;2-K |
0.596 |
|
| 1996 |
Lomize AL, Pogozheva ID, Mosberg HI. Development of a model for the δ-opioid receptor pharmacophore: 3. Comparison of the cyclic tetrapeptide, Tyr-c [D-Cys-Phe-D-Pen] OH with other conformationally constrained δ-receptor selective ligands Biopolymers. 38: 221-234. PMID 8589255 |
0.546 |
|
| 1994 |
Vanderah T, Takemori AE, Sultana M, Portoghese PS, Mosberg HI, Hruby VJ, Haaseth RC, Matsunaga TO, Porreca F. Interaction of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes in vivo. European Journal of Pharmacology. 252: 133-7. PMID 8157053 DOI: 10.1016/0014-2999(94)90588-6 |
0.57 |
|
| 1994 |
Mosberg HI, Omnaas JR, Lomize A, Heyl DL, Nordan I, Mousigian C, Davis P, Porreca F. Development of a model for the δ opioid receptor pharmacophore. 2. Conformationally restricted Phe3 replacements in the Cyclic δ receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) Journal of Medicinal Chemistry. 37: 4384-4391. PMID 7996550 DOI: 10.1021/Jm00051A016 |
0.566 |
|
| 1994 |
Mosberg HI, Lomize AL, Wang C, Kroona H, Heyl DL, Sobczyk-Kojiro K, Ma W, Mousigian C, Porreca F. Development of a model for the delta opioid receptor pharmacophore. 1. Conformationally restricted Tyr1 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13). Journal of Medicinal Chemistry. 37: 4371-83. PMID 7996549 DOI: 10.1021/jm00051a015 |
0.605 |
|
| 1994 |
Lomize AL, Flippen-Anderson JL, George C, Mosberg HI. Conformational analysis of the δ receptor-selective, cyclic opioid peptide, Tyr-cyclo[D-Cys-Phe-D-Pen]OH (JOM-13). Comparison of X-ray crystallographic structures, molecular mechanics simulations, and 1H NMR data Journal of the American Chemical Society. 116. DOI: 10.1021/Ja00081A001 |
0.433 |
|
| 1994 |
Mosberg HI, Omnaas JR, Sobczyk-Kojiro K, Dua R, Ho JC, Ma W, Bush P, Mousigian C, Lomize A. Pharmacophore elements of the TIPP class of delta opioid receptor antagonists Letters in Peptide Science. 1: 69-72. DOI: 10.1007/Bf00126275 |
0.688 |
|
| 1993 |
Raffa RB, Wild KD, Mosberg HI, Porreca F. Thermodynamic parameters for [D-Pen2,5]enkephalin at δ-opioid receptors in the mouse isolated vas deferens European Journal of Pharmacology: Molecular Pharmacology. 244: 231-238. PMID 8384567 DOI: 10.1016/0922-4106(93)90148-3 |
0.484 |
|
| 1993 |
Wild KD, Carlisi VJ, Mosberg HI, Bowen WD, Portoghese PS, Sultana M, Takemori AE, Hruby VJ, Porreca F. Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens. The Journal of Pharmacology and Experimental Therapeutics. 264: 831-8. PMID 8382281 |
0.421 |
|
| 1993 |
Mosberg HI, Porreca F. A model for the structural basis of delta 2-opioid receptor selectivity Nida Research Monograph. 134: 268-280. PMID 8289883 |
0.451 |
|
| 1993 |
Comer SD, McNutt RW, Chang KJ, De Costa BR, Mosberg HI, Woods JH. Discriminative stimulus effects of BW373U86: a nonpeptide ligand with selectivity for delta opioid receptors. The Journal of Pharmacology and Experimental Therapeutics. 267: 866-74. PMID 8246161 |
0.38 |
|
| 1993 |
Vanderah TW, Wild KD, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Hruby VJ, Mosberg HI, Porreca F. Modulation of morphine antinociception by swim-stress in the mouse: involvement of supraspinal opioid delta-2 receptors. The Journal of Pharmacology and Experimental Therapeutics. 267: 449-55. PMID 8229774 |
0.333 |
|
| 1992 |
Bai JPF, Hu M, Subramanian P, Mosberg HI, Amidon GL. Utilization of peptide carrier system to improve intestinal absorption: Targeting prolidase as a prodrug-converting enzyme Journal of Pharmaceutical Sciences. 81: 113-116. PMID 1545347 DOI: 10.1002/Jps.2600810202 |
0.308 |
|
| 1992 |
DeLander GE, Mosberg HI, Porreca F. Involvement of adenosine in antinociception produced by spinal or supraspinal receptor-selective opioid agonists: Dissociation from gastrointestinal effects in mice Journal of Pharmacology and Experimental Therapeutics. 263: 1097-1104. PMID 1335055 |
0.391 |
|
| 1992 |
Raffa RB, Wild KD, Mosberg HI, Porreca F. Thermodynamic analysis of the temperature dependence of the dissociation constant of naloxone at opioid delta receptors in the mouse isolated vas deferens Journal of Pharmacology and Experimental Therapeutics. 263: 1030-1035. PMID 1335052 |
0.378 |
|
| 1992 |
Mosberg HI, Kroona HB. Incorporation of a novel conformationally restricted tyrosine analog into a cyclic, δ opioid receptor selective tetrapeptide (JOM-13) enhances δ receptor binding affinity and selectivity Journal of Medicinal Chemistry. 35: 4498-4500. PMID 1333014 DOI: 10.1021/Jm00101A030 |
0.578 |
|
| 1992 |
Heyl DL, Mosberg HI. Modification of the Phe3 aromatic moiety in delta receptor-selective dermorphin/deltorphin-related tetrapeptides. Effects on opioid receptor binding International Journal of Peptide and Protein Research. 39: 450-457. PMID 1330964 DOI: 10.1111/J.1399-3011.1992.Tb01449.X |
0.615 |
|
| 1992 |
Porreca F, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Mosberg HI. Modulation of mu-mediated antinociception in the mouse involves opioid delta-2 receptors. The Journal of Pharmacology and Experimental Therapeutics. 263: 147-52. PMID 1328602 |
0.425 |
|
| 1992 |
Vanderah TW, Wild KD, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Mosberg HI, Porreca F. Mediation of swim-stress antinociception by the opioid delta 2 receptor in the mouse. The Journal of Pharmacology and Experimental Therapeutics. 262: 190-7. PMID 1320682 |
0.383 |
|
| 1992 |
Heyl DL, Mosberg HI. Substitution on the Phe3 aromatic ring in cyclic δ opioid receptor-selective dermorphin/deltorphin tetrapeptide analogues: Electronic and lipophilic requirements for receptor affinity Journal of Medicinal Chemistry. 35: 1535-1541. PMID 1315870 DOI: 10.1021/Jm00087A006 |
0.59 |
|
| 1992 |
Hansen DW, Stapelfeld A, Savage MA, Reichman M, Hammond DL, Haaseth RC, Mosberg HI. Systemic analgesic activity and δ-opioid selectivity in [2,6-dimethyl-Tyr1,D-Pen2,D-Pen5]enkephalin Journal of Medicinal Chemistry. 35: 684-687. PMID 1311764 DOI: 10.1021/Jm00082A008 |
0.529 |
|
| 1992 |
Mattia A, Farmer SC, Takemori AE, Sultana M, Portoghese PS, Mosberg HI, Bowen WD, Porreca F. Spinal opioid delta antinociception in the mouse: mediation by a 5'-NTII-sensitive delta receptor subtype. The Journal of Pharmacology and Experimental Therapeutics. 260: 518-25. PMID 1310737 |
0.441 |
|
| 1991 |
Heyl DL, Omnaas JR, Sobczyk-Kojiro K, Medzihradsky F, Smith CB, Mosberg HI. Opioid receptor affinity and selectivity effects of second residue and carboxy terminal residue variation in a cyclic disulfide-containing opioid tetrapeptide. International Journal of Peptide and Protein Research. 37: 224-9. PMID 1651290 DOI: 10.1111/J.1399-3011.1991.Tb00274.X |
0.605 |
|
| 1991 |
Mattia A, Vanderah T, Mosberg HI, Porreca F. Lack of antinociceptive cross-tolerance between [D-Pen2, D-Pen5]enkephalin and [D-Ala2]deltorphin ii in mice: Evidence for delta receptor subtypes Journal of Pharmacology and Experimental Therapeutics. 258: 583-87. PMID 1650835 |
0.307 |
|
| 1991 |
Mattia A, Vanderah T, Mosberg HI, Omnaas JR, Bowen WD, Porreca F. Pharmacological characterization of [D-Ala2,Leu5,Ser6]enkephalin (DALES): antinociceptive actions at the δnon-complexed-opioid receptor European Journal of Pharmacology. 192: 371-375. PMID 1647317 DOI: 10.1016/0014-2999(91)90227-H |
0.585 |
|
| 1991 |
Wild KD, Vanderah T, Mosberg HI, Porreca F. Opioid δ receptor subtypes are associated with different potassium channels European Journal of Pharmacology. 193: 135-136. PMID 1646729 DOI: 10.1016/0014-2999(91)90215-C |
0.328 |
|
| 1991 |
Jiang Q, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Mosberg HI, Porreca F. Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes. The Journal of Pharmacology and Experimental Therapeutics. 257: 1069-75. PMID 1646319 |
0.383 |
|
| 1990 |
Sheldon RJ, Riviere PJM, Malarchik ME, Mosberg HI, Burks TF, Porreca F. Opioid regulation of mucosal ion transport in the mouse isolated jejunum Journal of Pharmacology and Experimental Therapeutics. 253: 144-151. PMID 2329501 |
0.371 |
|
| 1990 |
Qi J, Mosberg HI, Porreca F. Selective modulation of morphine antinociception, but not development of tolerance, by δ receptor agonists European Journal of Pharmacology. 186: 137-141. PMID 2178093 DOI: 10.1016/0014-2999(90)94071-5 |
0.475 |
|
| 1990 |
Haaseth RC, Sobczyk-Kojiro K, Medzihradsky F, Smith CB, Mosberg HI. Single residue modifications of the delta opioid receptor selective peptide, [D-Pen2,D-Pen5]-enkephalin (DPDPE). Correlation of pharmacological effects with structural and conformational features. International Journal of Peptide and Protein Research. 36: 139-46. PMID 2177042 DOI: 10.1111/J.1399-3011.1990.Tb00957.X |
0.613 |
|
| 1990 |
Mosberg HI, Heyl DL, Haaseth RC, Omnaas JR, Medzihradsky F, Smith CB. Cyclic dermorphin-like tetrapeptides with delta-opioid receptor selectivity. 3. Effect of residue 3 modification on in vitro opioid activity. Molecular Pharmacology. 38: 924-8. PMID 2174509 |
0.569 |
|
| 1990 |
Jiang Q, Bowen WD, Mosberg HI, Rothman RB, Porreca F. Opioid agonist and antagonist antinociceptive properties of [D-Ala2,Leu5,Cys6]enkephalin: Selective actions at the delta(noncomplexed) site Journal of Pharmacology and Experimental Therapeutics. 255: 636-641. PMID 2173752 |
0.478 |
|
| 1990 |
Jiang Q, Mosberg HI, Porreca F. Antinociceptive effects of [D-Ala2]deltorphin II, a highly selective δ agonist in vivo Life Sciences. 47. PMID 2170791 DOI: 10.1016/0024-3205(90)90545-3 |
0.469 |
|
| 1990 |
Jiang Q, Mosberg HI, Porreca F. Modulation of the potency and efficacy of mu-mediated antinociception by delta agonists in the mouse Journal of Pharmacology and Experimental Therapeutics. 254: 683-689. PMID 2166801 |
0.409 |
|
| 1990 |
Mosberg HI, Sobczyk-Kojiro K, Subramanian P, Crippen GM, Ramalingam K, Woodard RW. Combined use of stereospecific deuteration, NMR, distance geometry, and energy minimization for the conformational analysis of the highly δ opioid receptor selective peptide [D-Pen2,D-Pen5]enkephalin Journal of the American Chemical Society. 112: 822-829. DOI: 10.1021/Ja00158A049 |
0.486 |
|
| 1990 |
Porreca F, Mosberg H, Jiang Q. Modulation of μ-opioid potency and efficacy by opioid δ-agonists without increasing the rate of development of tolerance and degree of physical dependence Pain. 41: S196. DOI: 10.1016/0304-3959(90)92528-X |
0.347 |
|
| 1989 |
Hu M, Subramanian P, Mosberg HI, Amidon GL. Use of the Peptide Carrier System to Improve the Intestinal Absorption of L-α-Methyldopa: Carrier Kinetics, Intestinal Permeabilities, and In Vitro Hydrolysis of Dipeptidyl Derivatives of L-α-Methyldopa Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 6: 66-70. PMID 2717522 DOI: 10.1023/A:1015855820488 |
0.327 |
|
| 1989 |
Heyman JS, Jiang Q, Rothman RB, Mosberg HI, Porreca F. Modulation of μ-mediated antinociception by δ agonists: characterization with antagonists European Journal of Pharmacology. 169: 43-52. PMID 2557223 DOI: 10.1016/0014-2999(89)90815-7 |
0.516 |
|
| 1989 |
Heyman JS, Vaught JL, Mosberg HI, Haaseth RC, Porreca F. Modulation of μ-mediated antinociception by δ agonists in the mouse: selective potentiation of morphine and normorphine by [D-Pen2, D-Pen5]enkephalin European Journal of Pharmacology. 165: 1-10. PMID 2548877 DOI: 10.1016/0014-2999(89)90764-4 |
0.535 |
|
| 1988 |
Cowan A, Zhu XZ, Mosberg HI, Omnaas JR, Porreca F. Direct dependence studies in rats with agents selective for different types of opioid receptor Journal of Pharmacology and Experimental Therapeutics. 246: 950-955. PMID 2901490 |
0.415 |
|
| 1988 |
Tortella FC, Echevarria E, Robles L, Mosberg HI, Holaday JW. Anticonvulsant effects of mu (DAGO) and delta (DPDPE) enkephalins in rats Peptides. 9: 1177-1181. PMID 2854247 DOI: 10.1016/0196-9781(88)90104-0 |
0.483 |
|
| 1988 |
Mosberg HI, Haaseth RC, Ramalingam K, Mansour A, Akil H, Woodard RW. Role of steric interactions in the delta opioid receptor selectivity of [D-Pen2, D-Pen5]enkephalin. International Journal of Peptide and Protein Research. 32: 1-8. PMID 2851561 DOI: 10.1111/J.1399-3011.1988.Tb00919.X |
0.471 |
|
| 1988 |
Mosberg HI, Omnaas JR, Medzihradsky F, Smith CB. Cyclic, disulfide- and dithioether-containing opioid tetrapeptides: development of a ligand with high delta opioid receptor selectivity and affinity. Life Sciences. 43: 1013-20. PMID 2845204 DOI: 10.1016/0024-3205(88)90547-4 |
0.614 |
|
| 1988 |
Heyman JS, Williams CL, Burks TF, Mosberg HI, Porreca F. Dissociation of opioid antinociception and central gastrointestinal propulsion in the mouse: Studies with naloxonazine Journal of Pharmacology and Experimental Therapeutics. 245: 238-243. PMID 2834537 |
0.39 |
|
| 1987 |
Mosberg HI. 1H-n.m.r. investigation of conformational features of cyclic, penicillamine-containing enkephalin analogs International Journal of Peptide and Protein Research. 29: 282-288. PMID 3570668 DOI: 10.1111/J.1399-3011.1987.Tb02255.X |
0.49 |
|
| 1987 |
Mosberg HI, Omnaas JR, Goldstein A. Structural requirements for δ opioid receptor binding Molecular Pharmacology. 31: 599-602. PMID 3037296 |
0.545 |
|
| 1987 |
Porreca F, Heyman JS, Mosberg HI, Omnaas JR, Vaught JL. Role of mu and delta receptors in the supraspinal and spinal analgesic effects of [D-Pen2, D-Pen5]Enkephalin in the mouse Journal of Pharmacology and Experimental Therapeutics. 241: 393-400. PMID 3033214 DOI: 10.1016/0304-3959(88)90102-9 |
0.342 |
|
| 1987 |
Porreca F, Mosberg HI, Omnaas JR, Burks TF, Cowan A. Supraspinal and spinal potency of selective opioid agonists in the mouse writhing test Journal of Pharmacology and Experimental Therapeutics. 240: 890-894. PMID 3031278 |
0.302 |
|
| 1987 |
Tortella FC, Robles L, Mosberg HI. Evidence of Mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures Journal of Pharmacology and Experimental Therapeutics. 240: 571-577. PMID 3027318 |
0.406 |
|
| 1987 |
Heyman JS, Mulvaney SA, Mosberg HI, Porreca F. Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice. Brain Research. 420: 100-8. PMID 2823970 DOI: 10.1016/0006-8993(87)90244-7 |
0.428 |
|
| 1987 |
Mosberg HI, Omnaas JR, Ramalingam K, Woodard RW. Synthesis of deuterium labelled penicillamine and its use for the assignment of the 1H NMR spectra of two cyclic enkephalin analogs Journal of Labelled Compounds and Radiopharmaceuticals. 24: 1265-1271. DOI: 10.1002/Jlcr.2580241014 |
0.439 |
|
| 1986 |
Heyman JS, Koslo RJ, Mosberg HI, Tallarida RJ, Porreca F. Estimation of the affinity of naloxone at supraspinal and spinal opioid receptors in vivo: Studies with receptor selective agonists Life Sciences. 39: 1795-1803. PMID 3022095 DOI: 10.1016/0024-3205(86)90099-8 |
0.534 |
|
| 1986 |
Cowan A, Zhu XZ, Mosberg HI, Porreca F. Central infusion of rats with agents selective for different types of opioid receptor Nida Research Monograph Series. 132-137. PMID 3018570 |
0.365 |
|
| 1986 |
Spencer RL, Deupree D, Hsiao S, Mosberg HI, Hruby V, Burks TF, Porreca F. Centrally-administered opioid selective agonists inhibit drinking in the rat Pharmacology, Biochemistry and Behavior. 25: 77-82. PMID 2875475 DOI: 10.1016/0091-3057(86)90233-9 |
0.476 |
|
| 1986 |
Heyman JS, Mosberg HI, Porreca F. Evidence for delta receptor mediation of [D-Pen2,D-Pen5]-enkephalin (DPDPE) analgesia in mice Nida Research Monograph. 75: 442-445. PMID 2828989 |
0.453 |
|
| 1985 |
Gulya K, Gehlert DR, Wamsley JK, Mosberg HI, Hruby VJ, Duckles SP, Yamamura HI. Autoradiographic localization of delta opioid receptors in the rat brain using a highly selective bis-penicillamine cyclic enkephalin analog. European Journal of Pharmacology. 111: 285-6. PMID 2990955 DOI: 10.1016/0014-2999(85)90770-8 |
0.504 |
|
| 1985 |
Hirning LD, Mosberg HI, Hurst R, Hruby VJ, Burks TF, Porreca F. Studies in vitro with ICI 174, 864, [D-Pen2, D-Pen5]-enkephalin (DPDPE) and [D-Ala2, NMePhe4, Gly-ol]-enkephalin (DAGO) Neuropeptides. 5: 383-386. PMID 2987739 DOI: 10.1016/0143-4179(85)90034-4 |
0.502 |
|
| 1985 |
Akiyama K, Gee KW, Mosberg HI, Hruby VJ, Yamamura HI. Characterization of [3H][2-D-penicillamine, 5-D-penicillamine]-enkephalin binding to delta opiate receptors in the rat brain and neuroblastoma--glioma hybrid cell line (NG 108-15). Proceedings of the National Academy of Sciences of the United States of America. 82: 2543-7. PMID 2986120 DOI: 10.1073/Pnas.82.8.2543 |
0.451 |
|
| 1985 |
Mosberg HI, Omnaas JR. Dithioether-containing cyclic peptides Journal of the American Chemical Society. 107: 2986-2987. DOI: 10.1002/Chin.198542340 |
0.335 |
|
| 1984 |
Mosberg HI, Schiller PW. 1H n.m.r. investigation of conformational features of cyclic enkephalinamide analogs International Journal of Peptide and Protein Research. 23: 462-466. PMID 6735586 DOI: 10.1111/J.1399-3011.1984.Tb02746.X |
0.495 |
|
| 1984 |
Galligan JJ, Mosberg HI, Hurst R, Hruby VJ, Burks TF. Cerebral delta opioid receptors mediate analgesia but not the intestinal motility effects of intracerebroventricularly administered opioids. The Journal of Pharmacology and Experimental Therapeutics. 229: 641-8. PMID 6327967 |
0.428 |
|
| 1984 |
Tortella FC, Robles L, Mosberg HI, Holaday JW. Electroencephalographic assessment of the role of δ receptors in opioid peptide - induced seizures Neuropeptides. 5: 213-216. PMID 6099500 DOI: 10.1016/0143-4179(84)90065-9 |
0.421 |
|
| 1984 |
Porreca F, Mosberg HI, Hurst R, Hruby VJ, Burks TF. Roles of Mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse Journal of Pharmacology and Experimental Therapeutics. 230: 341-348. PMID 6086883 |
0.44 |
|
| 1983 |
Porreca F, Mosberg HI, Hurst R, Hruby VJ, Burks TF. A comparison of the analgesic and gastrointestinal transit effects of [D-Pen2, L-Cys5] enkephalin after intracerebroventricular and intrathecal administration to mice Life Sciences. 33: 457-460. PMID 6689355 DOI: 10.1016/0024-3205(83)90540-4 |
0.38 |
|
| 1983 |
Hruby VJ, Mosberg HI, Sawyer TK, Knittel JJ, Rockway TW, Ormberg J, Darman P, Chan WY, Hadley ME. Conformational and dynamic considerations in the design of peptide hormone analogs Biopolymers. 22: 517-530. PMID 6673771 DOI: 10.1002/Bip.360220165 |
0.44 |
|
| 1983 |
Mosberg HI, Hurst R, Hruby VJ, Gee K, Akiyama K, Yamamura HI, Galligan JJ, Burks TF. Cyclic penicillamine containing enkephalin analogs display profound delta receptor selectivities. Life Sciences. 33: 447-50. PMID 6319901 DOI: 10.1016/0024-3205(83)90538-6 |
0.454 |
|
| 1983 |
Mosberg HI, Hurst R, Hruby VJ, Gee K, Yamamura HI, Galligan JJ, Burks TF. Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors. Proceedings of the National Academy of Sciences of the United States of America. 80: 5871-4. PMID 6310598 DOI: 10.1073/Pnas.80.19.5871 |
0.552 |
|
| 1983 |
Mosberg HI, Hurst R, Hruby VJ, Galligan JJ, Burks TF, Gee K, Yamamura HI. Conformationally constrained cyclic enkephalin analogs with pronounced delta opioid receptor agonist selectivity. Life Sciences. 32: 2565-9. PMID 6304440 DOI: 10.1016/0024-3205(83)90239-4 |
0.539 |
|
| 1982 |
Hruby VJ, Mosberg HI. Conformational and dynamic considerations in peptide structure-function studies Peptides. 3: 329-336. PMID 7122270 DOI: 10.1016/0196-9781(82)90095-X |
0.476 |
|
| 1982 |
Hruby VJ, Mosberg HI, Fox JW, Tu AT. Conformational comparisons of oxytocin agonists, partial agonists, and antagonists using laser raman and circular dichroism spectroscopy. Examination of 1-penicillamine and diastereoisomeric analogues Journal of Biological Chemistry. 257: 4916-4924. PMID 7068672 |
0.359 |
|
| 1982 |
Mosberg HI, Hurst R, Hruby VJ, Galligan JJ, Burks TF, Gee K, Yamamura HI. [D-Pen2, L-Cys5]enkephalinamide and[D-Pen2, D-Cys5] enkephalinamide, conformationally constrained cyclic enkephalinamide analogs with delta receptor specificity. Biochemical and Biophysical Research Communications. 106: 506-12. PMID 6285922 DOI: 10.1016/0006-291X(82)91139-1 |
0.466 |
|
| 1982 |
Hruby VJ, Mosberg HI, Viswanatha V. Active-site studies of neurohypophyseal hormones: Comparison of oxytocin and arginine-vasopressin with analogues containing 4-D-glutamine Journal of the American Chemical Society. 104: 837-841. DOI: 10.1021/Ja00367A031 |
0.44 |
|
| 1982 |
Mosberg HI. Long-range spin–spin coupling as an aid for the assignment of aromatic residues in peptide 1H-nmr spectra Biopolymers. 21: 2483-2486. DOI: 10.1002/Bip.360211213 |
0.322 |
|
| 1981 |
Mosberg HI, Hruby VJ, Meraldi JP. Conformational study of the potent peptide hormone antagonist [1-penicillamine,2-leucine]oxytocin in aqueous solution Biochemistry. 20: 2822-2828. PMID 7248250 DOI: 10.1021/Bi00513A018 |
0.455 |
|
| 1980 |
Mosberg HI, Scogin DA, Storm DR, Gennis RB. Proton nuclear magnetic resonance studies on bacitracin A and its interaction with zinc ion Biochemistry. 19: 3353-3357. PMID 7407048 DOI: 10.1021/Bi00555A039 |
0.332 |
|
| 1980 |
Scogin DA, Mosberg HI, Storm DR, Gennis RB. Binding of nickel and zinc ions to bacitracin A Biochemistry. 19: 3348-3352. PMID 7407047 DOI: 10.1021/Bi00555A038 |
0.314 |
|
| 1980 |
Hruby VJ, Mosberg HI, Hadley ME, Chan WY, Powell AM. Synthesis, pharmacological, conformational, and dynamic studies of the potent hormone antagonists [1-penicillamine, 4-threonine]-oxytocin and [1-penicillamine, 2-phenylalanine, 4-threonine]-oxytocin. Conformational and dynamic considerations in the design of antagonists International Journal of Peptide and Protein Research. 16: 372-381. PMID 7216613 DOI: 10.1111/J.1399-3011.1980.Tb02961.X |
0.352 |
|
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